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Comparison of three sedation protocols using midazolam and opioids in domestic ferrets (Mustela Putorius Furo) 咪达唑仑和阿片类药物对家貂镇静方案的比较
IF 0.6 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-10-01 Epub Date: 2025-09-23 DOI: 10.1053/j.jepm.2025.09.017
Jessie Vandenbruggen , Barbara Ambros , Hugues Beaufrère , Isabelle Desprez

Background

Performing routine diagnostic tests in ferrets can be challenging without sedation, and intramuscular injections may be problematic due to their limited muscle mass. This study aimed to achieve moderate sedation levels using subcutaneously administered combinations of opioids and midazolam in ferrets. The effects, quality, and duration of sedation, as well as the cardiovascular and respiratory effects of midazolam in combination with three different opioids, were also evaluated.

Methods

Twelve healthy adult ferrets were used in a randomized, blinded, crossover study. Three sedation protocols were evaluated: MM group with midazolam (0.5 mg/kg SC) and methadone (0.3 mg/kg SC), MB group with midazolam (0.5 mg/kg SC) and butorphanol (0.2 mg/kg SC) and MH group with midazolam (0.5 mg/kg SC) and hydromorphone (0.2 mg/kg SC). Sedation scores and vital parameters were recorded every five minutes.

Results

All 12 ferrets lost their righting reflex in the MB group and 11 out of 12 in the MH group. In the MM group, only 1 out of 12 lost his righting reflex, and for only 2 minutes. The median sedation duration (between loss and return of righting reflex) was 33.5 minutes (4–66) in the MH group and 42 minutes (36–72) in the MB group. MB group had a significantly shorter time to sternal recumbency, lateral recumbency and loss of righting reflex compared to MH group. The heart rate was significantly lower with MB when compared to MH, and MB induced significantly lower respiratory rates compared to both MH and MM. Retching and vomiting were observed in 84% of ferrets in the MH group, 42% in the MM group and 17% in the MB group.

Conclusion and clinical relevance

Subcutaneous administration of midazolam at 0.5 mg/kg in combination with either hydromorphone at 0.2 mg/kg or butorphanol at 0.2 mg/kg achieved moderate sedation. The combination of midazolam and butorphanol used in this study showed fewer side effects and variability in sedation duration, which may make it a more appropriate choice in a clinical setting.
背景:在雪貂中进行常规诊断测试可能具有挑战性,如果没有镇静,并且由于其肌肉量有限,肌肉注射可能会有问题。本研究的目的是在雪貂中使用皮下给药阿片类药物和咪达唑仑的组合来达到中等镇静水平。我们还评估了咪达唑仑与三种不同阿片类药物联合使用的镇静效果、质量、持续时间以及心血管和呼吸作用。方法采用随机、盲法、交叉研究方法,选取12只健康成年雪貂。评估了三种镇静方案:MM组咪达唑仑(0.5 mg/kg SC)和美沙酮(0.3 mg/kg SC), MB组咪达唑仑(0.5 mg/kg SC)和丁托啡诺(0.2 mg/kg SC)和MH组咪达唑仑(0.5 mg/kg SC)和氢吗啡酮(0.2 mg/kg SC)。每5分钟记录一次镇静评分和重要参数。结果MB组12只雪貂均丧失翻正反射,MH组11只雪貂丧失翻正反射。在MM组中,12人中只有1人失去了翻正反射,而且只持续了2分钟。MH组的中位镇静时间(从翻正反射消失到恢复之间)为33.5分钟(4-66),MB组为42分钟(36-72)。与MH组相比,MB组到胸骨平卧、侧卧时间和翻正反射丧失时间均显著缩短。与MH相比,MB的心率明显降低,MB引起的呼吸频率也明显低于MH和MM。MH组84%的雪貂出现干呕和呕吐,MM组42%,MB组17%。结论及临床意义咪达唑仑(0.5 mg/kg)皮下注射联合氢吗啡酮(0.2 mg/kg)或丁托啡诺(0.2 mg/kg)可达到中度镇静效果。本研究中使用的咪达唑仑和布托啡诺联合使用显示出更少的副作用和镇静持续时间的可变性,这可能使其成为临床环境中更合适的选择。
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引用次数: 0
Surgical correction of unilateral entropion in a Syrian hamster 叙利亚仓鼠单侧内翻的手术矫正
IF 0.6 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-10-01 Epub Date: 2025-09-11 DOI: 10.1053/j.jepm.2025.09.001
Audrey Simonian, Giulianna Obeid, Lara Cusack

Background

This case report describes the diagnosis, medical management, and surgical correction of congenital entropion with secondary trichiasis, blepharitis, and conjunctivitis in a 3-month-old male Syrian hamster (Mesocricetus auratus).

Case description

The patient presented with chronic left ocular discharge and eyelid inflammation that persisted despite medical therapy, including topical and systemic antibiotics, anti-inflammatory medications, and environmental modifications. A sedated ocular examination confirmed entropion and trichiasis, which were deemed the primary causes of ongoing ocular irritation. Surgical intervention, utilizing a modified Hotz-Celsus technique, was performed to correct the anatomical defect. Postoperative recovery was uneventful, with resolution of clinical signs and no recurrence observed during follow-up.

Conclusions and case relevance

Based on the literature search described below, this is the first reported case of surgical entropion correction in a Syrian hamster. The case highlights the challenges of diagnosing and managing ophthalmic conditions in small rodents, including limitations in ophthalmic examination, the importance of husbandry modifications, and the risks associated with anesthesia in these species. This report underscores the feasibility of surgical intervention in hamsters when medical management fails and provides insights into the multifactorial etiology of ocular disease in this species. Further research is needed to evaluate long-term outcomes and refine treatment protocols for ophthalmic conditions in hamsters.
本病例报告描述了一只3个月大的雄性叙利亚仓鼠(auratus Mesocricetus)先天性内翻合并继发性倒睫、眼睑炎和结膜炎的诊断、医疗处理和手术矫正。病例描述:患者表现为慢性左眼分泌物和眼睑炎症,尽管药物治疗,包括局部和全身抗生素、抗炎药物和环境改变,但持续存在。镇静眼科检查证实内翻和倒睫,这被认为是持续眼部刺激的主要原因。采用改良的Hotz-Celsus技术进行手术干预以纠正解剖缺陷。术后恢复顺利,临床症状消失,随访中未见复发。结论和病例相关性:根据下面描述的文献检索,这是叙利亚仓鼠手术内翻矫正的第一例报道。该病例强调了诊断和管理小型啮齿动物眼部疾病的挑战,包括眼科检查的局限性、饲养方式调整的重要性以及这些物种麻醉相关的风险。本报告强调了在医疗管理失败时仓鼠手术干预的可行性,并提供了对该物种眼部疾病多因素病因的见解。需要进一步的研究来评估仓鼠眼部疾病的长期结果和完善治疗方案。
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引用次数: 0
Review of: Ballard B and Cheek R, editors. “Exotic animal medicine for the veterinary technician”, 4th edition. Wiley Blackwell Inc, 705p; 2024 综述:Ballard B和Cheek R,编辑。《兽医技术人员用外来动物药》,第4版。Wiley Blackwell Inc ., 705便士;2024
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-07-23 DOI: 10.1053/j.jepm.2025.06.002
Lorelei D’Avolio
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引用次数: 0
Risk and protective factors associated with clinical urolithiasis in pet guinea pigs (Cavia porcellus) 宠物豚鼠(porcavia porcellus)临床尿石症的风险及保护因素
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-07-14 DOI: 10.1053/j.jepm.2025.07.005
Hannah J. Dadah , Michelle G. Hawkins , Andrea W. Munk , Jodi L. Westropp , Philip H. Kass , Hugues Beaufrère

Objective

To determine potential risk and protective factors for the development of clinical urolithiasis in pet guinea pigs.

Animals

Approximately 242 guinea pigs (Cavia porcellus).

Methods

Signalment, dietary and medical history were recorded from urolith submissions from affected guinea pigs. The controls were identified via an online survey from owners of nonclinical pet guinea pigs, and data was collected regarding signalment, past medical history and diet. Clinical urolithiasis is defined as animals having or had the presence of uroliths identified via imaging, surgery, or manual expulsion, and control subjects may include subclinical or asymptomatic cases. Diets for control and affected subjects were assessed for percentage of pellets, hay, fruits/vegetables, high-calcium dietary items and vitamin C offered. Models were constructed with the best fit evaluated using Hosmer-Lemeshow tests. The 2 predictive models used, %hay (PH) and %pellets (PP), could not be combined due to their collinear nature.

Results

Data from 70 affected and 172 control guinea pigs were included in the analyses. Guinea pigs ≥24 months had higher odds of developing urolithiasis (PH: OR = 30.74; 95% CI [6.26–150.9], P < 0.001; PP: OR = 19.23; 95% CI [4.64–79.65], P < 0.001). Animals ≥1300 grams were more protected against urolithiasis (PH: OR = 0.05; 95% CI [0.0042–0.48], P < 0.010; PP: OR = 0.05; 95% CI [0.0045–0.47], P < 0.009). Affected males were overrepresented (62.8%, 44/70). Diets higher in %hay (PH: OR = 0.94; 95% CI [0.91–0.97], P < 0.001) or greater variety of fruits/vegetables (>7 types) (PH: OR = 0.66; 95% CI [0.57–0.76], P < 0.001; PP: OR = 0.69; 95% CI [0.61–0.80], P < 0.001) were more protective; guinea pigs with diets higher in %pellets were more likely to develop urolithiasis (PP: OR = 1.05; 95% CI [1.02–1.09], P < 0.003). High moisture (>50%) food items, such as bell peppers, tomatoes and romaine lettuce were especially protective against the formation of uroliths.

Conclusions and clinical relevance

Age, body weight, sex and dietary factors are important considerations for the development of clinical urolithiasis in guinea pigs and should be considered when tailoring preventative strategies for guinea pigs.
目的探讨宠物豚鼠临床尿石症发生的潜在危险因素和保护因素。动物:大约242只豚鼠。方法记录感染豚鼠尿石的信号、饮食和病史。通过对非临床宠物豚鼠的主人进行在线调查,确定了对照组,并收集了有关信号、既往病史和饮食的数据。临床尿石症的定义是通过影像学、手术或人工排出术发现有或曾经存在尿石的动物,对照组可能包括亚临床或无症状病例。对对照组和受影响受试者的饮食进行了评估,包括颗粒、干草、水果/蔬菜、高钙饮食项目和维生素C的百分比。采用Hosmer-Lemeshow检验评估模型的最佳拟合。所使用的2个预测模型,%干草(PH)和%颗粒(PP),由于它们的共线性性质,不能组合。结果70只感染豚鼠和172只对照豚鼠的数据被纳入分析。≥24个月的豚鼠发生尿石症的几率更高(PH: OR = 30.74;95% CI [6.26-150.9], P <;0.001;Pp: or = 19.23;95% CI [4.64-79.65], P <;0.001)。≥1300克的动物更容易患尿石症(PH: OR = 0.05;95% CI [0.0042-0.48], P <;0.010;Pp: or = 0.05;95% CI [0.0045-0.47], P <;0.009)。男性患者比例过高(62.8%,44/70)。饲粮中干草含量较高(PH: OR = 0.94;95% CI [0.91-0.97], P <;0.001)或更多种类的水果/蔬菜(>;7种)(PH: or = 0.66;95% CI [0.57-0.76], P <;0.001;Pp: or = 0.69;95% CI [0.61-0.80], P <;0.001)保护作用更强;饲粮中颗粒含量较高的豚鼠更容易患尿石症(PP: OR = 1.05;95% CI [1.02-1.09], P <;0.003)。高水分(50%)的食物,如甜椒、西红柿和长叶莴苣,特别能防止尿石的形成。结论和临床相关性年龄、体重、性别和饮食因素是豚鼠临床尿石症发生的重要考虑因素,在制定豚鼠预防策略时应予以考虑。
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引用次数: 0
Veterinary spending patterns for pet rabbits in Spain 西班牙宠物兔的兽医支出模式
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-07-17 DOI: 10.1053/j.jepm.2025.07.006
Miguel Gallego-Agundez , Cristina Díaz-Berciano
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引用次数: 0
AEMV 3Q Newsletter 2025 AEMV第三季度通讯2025
IF 0.6 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-08-27 DOI: 10.1053/S1557-5063(25)00071-0
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引用次数: 0
Diagnosis and treatment of an ossified auricular hematoma in a domestic rabbit 家兔骨化性耳廓血肿的诊断与治疗
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-07-14 DOI: 10.1053/j.jepm.2025.07.001
Hilary S. Stern , Ethan Biswell
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引用次数: 0
Sex and age-specific select hematologic and biochemical reference intervals for koi (Cyprinus rubrofuscus) 锦鲤(Cyprinus rubrofuscus)按性别和年龄选择血液学和生化参考区间
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-05-10 DOI: 10.1053/j.jepm.2025.05.001
Alexandra T. Troiano , Melanie Ammersbach , Kelsey D. Brust , Kathryn L. Philips , Hugues Beaufrère , Esteban Soto

Background

Fish are the most numerous pet throughout the United States, and ornamental Koi (Cyprinus rubrofuscus) are one of the most common ornamental pet fish in California, USA. Previous reference intervals have been established in a small sample size of koi but differences between age and sex in ornamental koi have not been investigated. The objective of this study was to establish hematologic and biochemical reference intervals for healthy koi stratified by age (juvenile vs adult) and sex (male vs female).

Method

Blood samples were collected from 50 adult males, 50 adult females and 50 juvenile koi from a commercial vendor. Heparinized whole blood was used to perform a manual complete blood count (CBC) and biochemical parameters were analyzed from plasma samples. Reference intervals were determined using a non-parametric method to obtain the 2.5% and 97.5% percentiles following elimination of outliers.

Results

Many of the investigated laboratory values were found to be similar between groups, but statistically significant differences were found between ages for calcium, anion gap, and thrombocyte count, and among both age and sex for phosphorus, bicarbonate, aspartate aminotransferase (AST), glucose, red blood cell count (RBC), white blood cell count (WBC), and lymphocyte count.

Conclusions

Statistically significant differences between ages and sexes were found to exist for various analytes, but the differences are unlikely to be clinically relevant given the large degree of overlap of the partitioned reference intervals. Overall, reference intervals for the investigated hematological and biochemical values were similar in nonbreeding koi regardless of sex and age.
鱼类是美国数量最多的宠物,观赏锦鲤(Cyprinus rubrofuscus)是美国加利福尼亚州最常见的观赏宠物鱼之一。以前在小样本锦鲤中建立了参考区间,但尚未调查观赏锦鲤年龄和性别之间的差异。本研究的目的是建立按年龄(幼鱼与成鱼)和性别(雄鱼与雌鱼)分层的健康锦鲤血液学和生化参考区间。方法采集某商业养殖锦鲤成虫50只,成虫50只,幼鱼50只。用肝素化全血进行人工全血细胞计数(CBC),并分析血浆样本的生化参数。参考区间采用非参数方法确定,以获得排除异常值后的2.5%和97.5%百分位数。结果研究发现,许多实验室值在组间相似,但在钙、阴离子间隙和血小板计数方面,在年龄之间存在显著差异,在磷、碳酸氢盐、天冬氨酸转氨酶(AST)、葡萄糖、红细胞计数(RBC)、白细胞计数(WBC)和淋巴细胞计数方面,在年龄和性别之间存在显著差异。结论:各种分析物在年龄和性别之间存在统计学上的显著差异,但由于划分的参考区间有很大程度的重叠,这种差异不太可能具有临床相关性。总体而言,无论性别和年龄,所调查的非繁殖锦鲤血液学和生化值的参考区间是相似的。
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引用次数: 0
Avian & Exotic News 鸟类与异域新闻
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-07-24 DOI: 10.1053/j.jepm.2025.06.003
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引用次数: 0
Surgical management of metritis, salpingitis and vaginal tubular adenocarcinoma in a sugar glider (Petaurus breviceps) 糖滑翔机子宫炎、输卵管炎和阴道管状腺癌的手术治疗
IF 0.5 4区 农林科学 Q4 VETERINARY SCIENCES Pub Date : 2025-06-01 Epub Date: 2025-07-14 DOI: 10.1053/j.jepm.2025.07.004
Veronica Pardini , Bairon Madrigal
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引用次数: 0
期刊
Journal of Exotic Pet Medicine
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