Journal of Infection and Public Health最新文献

英文中文

RSV-associated hospitalizations in Bangladeshi children under five: Unveiling the disease burden 孟加拉国五岁以下儿童rsv相关住院：揭示疾病负担

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1016/j.jiph.2025.103067

Mst. Noorjahan Begum , Yeasir Karim , Sabik Khair , Sumaiya Binte Hannan , Selim Reza Tony , Nure Sharaf Nower Samia , Mohammad Jubair , Shaheen Alam , Mohammad Hridoy Patwary , Anisuddin Ahmed , Md Ariful Islam , Tanzir Ahmed Shuvo , Manjur Hossain Khan Jony , Tahmina Shirin , Fahmida Chowdhury , Firdausi Qadri , Mustafizur Rahman

Objectives

Respiratory Syncytial Virus (RSV) is a leading cause of acute lower respiratory tract infections among children under five years of age globally. Despite its significant health burden, data on RSV infection in this age group in Bangladesh are limited. This study aims to estimate the prevalence of RSV among hospitalized Bangladeshi children under five years of age and to explore its distribution across key demographic factors, including age, sex, and geographic region.

Methods

We designed the study based on the hospital-based influenza surveillance conducted by icddr,b, enrolling children who presented with severe acute respiratory infections (SARI) or influenza-like illness (ILI) symptoms. Both nasopharyngeal and oropharyngeal swabs from each participant were collected and subjected to real-time RT-PCR for RSV detection. Data were analyzed using descriptive statistics, chi-square tests and multiple logistic regression.

Results

From October 2022 to December 2024, we enrolled 8203 patients with SARI and ILI, of whom 2758 tested positive for RSV. RSV was detected at a significantly higher proportion among SARI cases 2583 (36 %), compared to ILI cases 175 (16 %) (p < 0.001). Infants under six months exhibited the highest infection proportion (44 %), with prevalence decreasing with age. RSV activity in Bangladesh begins in the southern districts in August and peaks nationwide between October and December.

Conclusions

This study highlights a significant RSV burden among children less than six months of age with SARI. These findings emphasize the need for targeted age-specific control measures to reduce hospitalization.

呼吸道合胞病毒（RSV）是全球5岁以下儿童急性下呼吸道感染的主要原因。尽管存在严重的健康负担，但孟加拉国这一年龄组RSV感染的数据有限。本研究旨在估计孟加拉国5岁以下住院儿童RSV患病率，并探讨其在关键人口因素（包括年龄、性别和地理区域）中的分布。方法本研究是基于icddr，b开展的以医院为基础的流感监测，纳入出现严重急性呼吸道感染（SARI）或流感样疾病（ILI）症状的儿童。收集每位参与者的鼻咽拭子和口咽拭子，进行实时RT-PCR检测RSV。数据分析采用描述性统计、卡方检验和多元逻辑回归。结果从2022年10月至2024年12月，我们纳入了8203例SARI和ILI患者，其中2758例RSV检测呈阳性。在急性呼吸道感染病例中，RSV的检出率为2583例（36 %），显著高于ILI病例175例（16 %）（p <； 0.001）。6个月以下婴儿感染率最高（44. %），感染率随年龄增长而下降。孟加拉国的呼吸道合胞病毒活动于8月在南部地区开始，10月至12月在全国达到高峰。结论：本研究强调了呼吸道合胞病毒在6个月以下严重急性呼吸道感染儿童中的显著负担。这些发现强调需要针对特定年龄的控制措施来减少住院。

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引用次数: 0

Malignant pertussis in infants: 4 new cases in French Guiana 婴儿恶性百日咳：法属圭亚那4例新病例

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-11-21 DOI: 10.1016/j.jiph.2025.103065

Cédric Ngila Lubunu , Christelle Samou-Fontcho , Urbain Agbessy Awanou , Narcisse Elenga

Malignant pertussis is a severe form of pertussis characterized by respiratory distress, polyvisceral failure, and marked hyperlymphocytosis. It typically presents with profound leukocytosis, pulmonary hypertension, and respiratory failure. We report four cases of malignant pertussis in young infants. One patient underwent exchange transfusion. The case fatality rate was 50 %. Preventing these severe and often fatal cases—associated with high mortality and significant intensive care costs—relies primarily on vaccination. Immunization should be ensured for all infants and extended to adults at risk of transmitting the infection to unimmunized infants.

恶性百日咳是一种严重的百日咳，以呼吸窘迫、多脏器功能衰竭和明显的淋巴细胞增多为特征。典型表现为严重的白细胞增多、肺动脉高压和呼吸衰竭。我们报告四例恶性百日咳在年轻的婴儿。一名患者接受了换血。病死率为50% %。预防这些与高死亡率和大量重症监护费用相关的严重且往往致命的病例主要依靠疫苗接种。应确保对所有婴儿进行免疫接种，并扩大到有将感染传播给未接种疫苗的婴儿风险的成年人。

引用次数: 0

SURGICAL GURARDING INFECTION RISK SCORE (SGIRS) TO REDUCE THE INCIDENCE OF SURGICAL SITE INFECTION AMONGST LSCS PATIENT OUTCOMES AND BEST PRACTICES 手术保护感染风险评分（sgirs）减少LSCS患者手术部位感染发生率的结果和最佳实践

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jiph.2025.103096

Zizi Wanis , Salam Alhasani , Amr Elmekresh

引用次数: 0

COMPREHENSIVE GENOMIC ANALYSIS OF VANCOMYCIN- AND DAPTOMYCIN-RESISTANT ENTEROCOCCUS FAECIUM BACTEREMIA IN A HIGH-RISK PATIENT 1例高危患者万古霉素和达托霉素耐药粪肠球菌菌血症的综合基因组分析

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jiph.2025.103102

Akela Ghazawi , Ashrat Manzoor , Maryam AlAzri , Noura AlNuaimi , Ahmed Al Hammadi , Mushtaq Khan

引用次数: 0

Comparative overview of Aspergillus fumigatus, A. flavus, and A. niger: Pathogenicity, resistance, and public health significance 烟曲霉、黄曲霉和黑曲霉的比较综述：致病性、耐药性和公共卫生意义

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1016/j.jiph.2025.103070

Affan Rafique , Sabrina Sharmin , Asef Raj , Ammarah Laaika Mohiuddin , Md. Iftekhar Al Mahmud , Humair Bin Md Omer

Fungal diseases represent a major global health challenge, with Aspergillus species like A. fumigatus, A. flavus, and A. niger acting as key opportunistic pathogens. These fungi cause a spectrum of illness from allergy to life-threatening invasive aspergillosis in immunocompromised patients. This review synthesizes evidence (2000–2025) on their pathogenicity, resistance, and clinical impact, providing a comparative analysis of species-specific differences in conidial morphology, secondary metabolite production, and virulence factors such hydrophobins, galactosaminogalactan, melanin, siderophores, biofilms. The increasing threat of triazole resistance, fueled by environmental fungicide use and climate change, is critically examined. The review also summarizes the current antifungal therapies (polyenes, triazoles, echinocandins) and investigational drugs, highlighting the urgent need for improved surveillance, stewardship and diagnostics, particularly in low- and middle-income countries, to guide targeted management and reduce the global burden of aspergillosis.

真菌疾病是全球健康面临的主要挑战，烟曲霉、黄曲霉和黑曲霉等曲霉是主要的机会致病菌。这些真菌在免疫功能低下的患者中引起一系列疾病，从过敏到危及生命的侵袭性曲霉病。这篇综述综合了2000-2025年关于它们的致病性、耐药性和临床影响的证据，提供了分生孢子形态、次生代谢物产生和毒力因子（如疏水蛋白、半乳糖胺半乳糖、黑色素、铁载体、生物膜）的物种特异性差异的比较分析。环境杀菌剂的使用和气候变化加剧了三唑耐药性的威胁，并对其进行了严格审查。该综述还总结了目前的抗真菌疗法（多烯、三唑、棘白菌素）和研究药物，强调迫切需要改进监测、管理和诊断，特别是在低收入和中等收入国家，以指导有针对性的管理和减轻全球曲霉病负担。

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引用次数: 0

Seroprevalence of four zoonotic viral diseases in camels in Qatar 卡塔尔骆驼四种人畜共患病毒性疾病的血清患病率

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-11-28 DOI: 10.1016/j.jiph.2025.103074

AlMaha A. AlSaiari , Nada M. Al-Karbi , Maria K. Smatti , Ahmed Gawish , Nahla O. Eltai , Asmaa A. Althani , Hadi M. Yassine

Background

Understanding the dynamics of zoonotic diseases is integral to the One Health approach, as it guides strategies to mitigate the impact of infections on both animal and human health. In Qatar, the circulation of many zoonotic viral infections among animals remains unknown.

Aim

This study aimed to investigate the seroprevalence of four zoonotic viral diseases in camels in Qatar: The Middle East respiratory syndrome coronavirus (MERS-CoV), in addition to three arboviruses (arthropod-borne viruses): [West Nile virus (WNV), Crimean-Congo hemorrhagic fever virus (CCHFV), and Rift Valley fever virus (RVFV)].

Methods

A total of 186 camel samples were collected from 23 farms at six municipalities in Qatar between 2019 and 2021. Specific anti-virus IgG or IgM antibodies were detected using commercial enzyme-linked immunosorbent assay (ELISA) kits.

Results

Overall, we found a high seroprevalence of MERS-CoV IgG in camels (95.1 %), followed by CCHFV IgG (56 %) and WNV IgG (23.3 %). On the other hand, the seropositivity of anti-RVFV IgG was 1.7 %, and none of the tested samples exhibited RVFV-reactive IgM antibodies. Moreover, 97 (52.2 %) camel samples tested positive for at least MERS-CoV- and CCHFV-reactive antibodies. Seroprevalences were comparable irrespective of the animals’ sex. Although MERS-CoV exposure was high in all age groups (>92 %), a statistically significant difference in the anti-MERS-CoV IgG ELISA OD values was observed between samples collected from camels aged 10 years or above compared to those below the age of 5 years (p = 0.018).

Conclusion

Our study provided evidence of a relatively high ratio of exposure to MERS-CoV, CCHFV, and WNV in camels in Qatar. To better understand these zoonotic viral diseases, additional studies involving larger animal populations, investigating vector dynamics, and monitoring livestock movements in and out of the country are imperative.

了解人畜共患疾病的动态是“同一个健康”方法不可或缺的一部分，因为它指导减轻感染对动物和人类健康影响的战略。在卡塔尔，许多人畜共患病毒感染在动物之间的传播情况仍然未知。目的调查卡塔尔骆驼中4种人畜共患病毒性疾病的血清患病率：中东呼吸综合征冠状病毒（MERS-CoV），以及3种虫媒病毒（节肢动物传播的病毒）：西尼罗病毒（WNV）、克里米亚-刚果出血热病毒（CCHFV）和裂谷热病毒（RVFV）。方法2019 - 2021年在卡塔尔6个城市的23个农场采集了186只骆驼样本。采用商用酶联免疫吸附试验（ELISA）试剂盒检测特异性抗病毒IgG或IgM抗体。结果骆驼血清MERS-CoV IgG阳性率最高（95.1% %），其次是CCHFV IgG（56% %）和WNV IgG（23.3% %）。另一方面，抗裂谷病毒IgG血清阳性率为1.7 %，所有检测样本均未出现裂谷病毒反应性IgM抗体。此外，97份（52.2% %）骆驼样本至少检测出MERS-CoV和cchfv反应性抗体阳性。不论动物的性别，血清患病率都具有可比性。尽管所有年龄组的MERS-CoV暴露率都很高（>92 %），但10岁及以上的骆驼与5岁以下的骆驼相比，抗MERS-CoV IgG ELISA OD值有统计学差异（p = 0.018）。结论本研究为卡塔尔骆驼暴露于MERS-CoV、CCHFV和WNV的比例较高提供了证据。为了更好地了解这些人畜共患病毒性疾病，必须开展涉及更大动物种群的进一步研究，调查病媒动态，并监测牲畜进出该国的情况。

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引用次数: 0

Prevalent fungal pathogens and antifungal resistance in Lebanon: A scoping review 黎巴嫩流行的真菌病原体和抗真菌耐药性：范围综述

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-11-20 DOI: 10.1016/j.jiph.2025.103062

Yara Khachab , Majd Bou Ghader , Vera Tahesh , Racha Khoumassi , Elie Salem Sokhn

Fungal infections are an increasing public health concern in Lebanon, particularly among immunocompromised individuals. Common pathogens include Candida albicans, C. glabrata (Nakaseomyces glabrata), C. parapsilosis, C. tropicalis, and emerging C. krusei (Pichia Kudriavzevii), alongside dermatophytes such as Trichophyton, Microsporum, and Epidermophyton species. Aspergillus fumigatus, A. flavus, A. niger, and A. tubingensis are the predominant causes of respiratory and systemic infections. Although azoles, echinocandins, and polyenes remain key antifungal agents, rising resistance particularly azole resistance in Aspergillus and echinocandin resistance in Candida poses a major therapeutic challenge.

真菌感染是黎巴嫩日益严重的公共卫生问题，特别是在免疫功能低下的人群中。常见的病原体包括白色念珠菌、光秃假丝酵母菌（光秃假丝酵母菌）、副枯枝假丝酵母菌、热带假丝酵母菌和新出现的克鲁塞假丝酵母菌（Pichia Kudriavzevii），以及毛癣菌、小孢子菌和表皮菌等皮肤真菌。烟曲霉，黄曲霉，黑曲霉和塔宾曲霉是呼吸道和全身感染的主要原因。虽然唑类、棘球白菌素和多烯类仍然是主要的抗真菌药物，但越来越多的耐药性，特别是曲霉对唑类的耐药性和念珠菌对棘球白菌素的耐药性，对治疗构成了重大挑战。

引用次数: 0

Effective alternative strategies to combat challenges associated with MDR bacterial infections: Drug repurposing, role of artificial intelligence, and novel therapeutic options 对抗耐多药细菌感染挑战的有效替代策略：药物再利用、人工智能的作用和新的治疗选择

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-11-17 DOI: 10.1016/j.jiph.2025.103058

Sayed E. El-Sayed , Albeir A. Messiha , Mai Zafer

Antibiotic failure has emerged as a critical global health concern, driven by a combination of factors including the stagnation in the discovery of new antibiotics, the widespread emergence of resistance mechanisms among clinical bacterial isolates, and the persistence of recurrent infections caused by tolerant and non-responsive bacterial populations. This review explores contemporary and innovative anti-infective strategies aimed at countering multidrug-resistant (MDR) and persistent bacterial pathogens. Key approaches discussed include the application of antimicrobial peptides, anti-virulence compounds, bacteriophage therapy, and the development of novel therapeutic molecules. Furthermore, this review highlights the strategic repurposing of existing FDA-approved drugs—such as anti-inflammatory, antipsychotic, anti-helminthic, anticancer agents, and statins—as alternative therapeutics. The integration of artificial intelligence in antimicrobial research is also addressed as a promising avenue to accelerate the identification of effective interventions against MDR infections.

抗生素失效已成为一个严重的全球健康问题，其驱动因素包括新抗生素的发现停滞不前，临床细菌分离株中耐药性机制的广泛出现，以及耐药和无反应细菌群体引起的反复感染持续存在。这篇综述探讨了当代和创新的抗感染策略，旨在对抗多药耐药（MDR）和持久性细菌病原体。讨论的主要方法包括抗菌肽的应用、抗毒化合物、噬菌体治疗和新型治疗分子的开发。此外，本综述强调了现有fda批准的药物（如抗炎药、抗精神病药、抗寄生虫药、抗癌药和他汀类药物）作为替代疗法的战略重新定位。人工智能在抗菌素研究中的整合也被认为是一种有希望的途径，可以加速确定针对耐多药感染的有效干预措施。

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引用次数: 0

ANALYSIS OF THE RESISTOME OF MULTI-DRUG RESISTANT GRAM-NEGATIVE PATHOGENS ISOLATED FROM PATIENTS WITH BACTERIAL PNEUMONIA 细菌性肺炎患者多重耐药革兰氏阴性病原菌的耐药性分析

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2026-01-08 DOI: 10.1016/j.jiph.2025.103094

Al Marzooq F , Al Ali N , Ahmed Y , Akhter I , Jog S , Nabi A , Ayoub Moubareck C

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Best Paper Award “Journal of Infection and Public Health” – 2025 Edition 最佳论文奖“感染与公共卫生杂志” - 2025年版

IF 4 3区医学 Q1 INFECTIOUS DISEASES

Journal of Infection and Public Health

Pub Date : 2026-02-01 Epub Date: 2025-12-29 DOI: 10.1016/j.jiph.2025.103125

引用次数: 0

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