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Fatal mechanical asphyxia: a comprehensive forensic review with an illustrative case 致命的机械窒息:综合法医审查与一个说明性的案例。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-30 DOI: 10.1016/j.jflm.2025.102988
Guodong Qin , Pengfei Zhao
Fatal asphyxia is one of the most diagnostically complex categories of sudden death because its macroscopic signs are often subtle, heterogeneous and easily confounded with post-mortem artefacts. We reviewed 38 English-language publications (2000–2025) that contained autopsy-confirmed asphyxial fatalities and re-coded every case into a five-group typology—mechanical, electrical, toxic (chemical), ambient-hypoxia and pathological (endogenous). Recurrent external findings, internal soft-tissue lesions and ancillary toxicological or histochemical markers were extracted, and the literature trends were anchored to day-to-day practice by a single illustrative non-homicidal thoracocervical-compression case from our regional medicolegal institute. Within the pooled dataset, neck compression accounted for 55 % of mechanical fatalities, yet petechial haemorrhages were absent in 38 % of those victims, and potential toxicological co-factors (ethanol, opioids or sedatives) were documented in almost one-third of all cases. These discrepancies expose blind spots in death-scene reconstruction and in the routine dissection of deep cervical tissues. Accordingly, we propose a pragmatic classification framework that forces explicit consideration of scene context, mandates layer-by-layer dissection of the neck and anterior thorax, and incorporates targeted toxicology to resolve ambiguous mechanisms. By integrating narrative evidence with real-world autopsy experience, the review delineates where current diagnostic protocols succeed and where they fail, providing forensic pathologists with a clearer decision pathway when evaluating suspected asphyxial deaths.
致死性窒息是诊断上最复杂的猝死类型之一,因为其宏观体征往往是微妙的,异质性的,很容易与死后的假象相混淆。我们回顾了38篇英文出版物(2000-2025年),其中包含尸检证实的窒息死亡病例,并将每个病例重新编码为五组类型-机械,电气,有毒(化学),环境缺氧和病理性(内源性)。我们提取了反复出现的外部表现、内部软组织病变和辅助的毒理学或组织化学标记物,并通过我们地区医学研究所的一个具有说明意义的非杀人性胸颈压迫病例,将文献趋势固定在日常实践中。在合并的数据集中,颈部压迫占机械死亡人数的55%,但38%的受害者没有点状出血,几乎三分之一的病例记录了潜在的毒理学辅助因素(乙醇、阿片类药物或镇静剂)。这些差异暴露了死亡现场重建和常规宫颈深部组织解剖的盲点。因此,我们提出了一个实用的分类框架,强制明确考虑场景背景,要求逐层解剖颈部和前胸,并结合目标毒理学来解决不明确的机制。通过将叙事证据与真实尸检经验相结合,该综述描述了当前诊断方案的成功和失败之处,为法医病理学家在评估疑似窒息死亡时提供了更清晰的决策途径。
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引用次数: 0
Towards automation of human stage of decay identification: An artificial intelligence approach 走向人类腐烂阶段识别的自动化:一种人工智能方法
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-29 DOI: 10.1016/j.jflm.2025.102987
Anna-Maria Nau , Phillip Ditto , Dawnie Wolfe Steadman , Audris Mockus
Determining the stage of decomposition (SOD) is one of the first steps necessary to estimate the postmortem interval, which may aid in identifying human remains. Currently, labor-intensive manual scoring methods are used for this purpose, but they are subjective and do not scale for the emerging large-scale archival collections of human decomposition photos. This study explores the feasibility of automating two human decomposition scoring methods proposed by Megyesi and Gelderman using artificial intelligence (AI). We evaluated two popular deep learning models, Inception V3 and Xception, by training them on a large dataset of human decomposition images to classify the SOD for different anatomical regions, including the head, torso, and limbs. Additionally, an interrater study was conducted to assess the reliability of the AI models compared to human forensic examiners for SOD identification. The Xception model achieved the best classification performance, with macro-averaged F1 scores of .878, .881, and .702 for the head, torso, and limbs when predicting Megyesi's SODs, and .872, .875, and .76 for the head, torso, and limbs, respectively, when predicting Gelderman's SODs. The interrater study results supported AI's ability to determine the SOD at a reliability level comparable to a human expert. This work demonstrates the potential of AI models trained on a large dataset of human decomposition images to automate SOD classification.
确定分解阶段(SOD)是估计死后时间间隔的必要步骤之一,这可能有助于识别人类遗骸。目前使用的是劳动密集型的人工评分方法,但这些方法比较主观,不适合新兴的大规模人体分解照片档案收藏。本研究探讨了Megyesi和Gelderman提出的两种人体分解评分方法使用人工智能(AI)实现自动化的可行性。我们评估了两种流行的深度学习模型,Inception V3和Xception,通过在大型人体分解图像数据集上训练它们对不同解剖区域(包括头部、躯干和四肢)的SOD进行分类。此外,进行了一项解释器研究,以评估人工智能模型与人类法医鉴定SOD的可靠性。Xception模型的分类性能最好,宏观平均F1得分为。878年,。881,和。702的头部,躯干和四肢在预测Megyesi的sod时,和。872年,。875,和。在预测格尔德曼的sod时,头部,躯干和四肢分别是76。解释器的研究结果支持人工智能在与人类专家相当的可靠性水平上确定SOD的能力。这项工作证明了人工智能模型在人类分解图像的大型数据集上训练的潜力,可以自动进行SOD分类。
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引用次数: 0
A continuous forensic spectral analysis study to identify antemortem and postmortem muscle contusions by chemometrics 一项持续的法医光谱分析研究,通过化学计量学来识别死前和死后的肌肉挫伤
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-29 DOI: 10.1016/j.jflm.2025.102986
Gongji Wang , Jianliang Luo , Zhengyang Zhu , Yuqian Li , Xinggong Liang , Hao Wu , Xin Wei , Zuan Deng , Kai Zhang , Zhenyuan Wang
The differentiation between antemortem and postmortem mechanical injuries constitutes a critical challenge in forensic pathology, particularly given the scarcity of reliable diagnostic markers for severely autolyzed or decomposed cadavers. This study pioneers an integrative methodology combining advanced morphological characterization, infrared spectroscopy, and chemometric modeling to identify molecular signatures distinguishing antemortem from postmortem trauma. The spectral analysis revealed distinct biomarker patterns associated with proteins (1643 cm−1 and 1560 cm−1), phospholipids (1402 cm−1), and carbohydrate complexes (1011 cm−1). These molecular fingerprints demonstrate significant discriminative potential in trauma vitality assessment. Through systematic pattern recognition, we developed optimized partial least squares-discriminant analysis (PLS-DA) models achieving superior classification accuracy in both cross-validation and external validation cohorts. The established protocol demonstrates three critical advantages: enhanced diagnostic reliability in advanced decomposition states, quantitative spectral interpretation through chemometric processing, and methodological standardization for prolonged postmortem intervals. This multimodal approach addresses a persistent forensic limitation, offering a scientifically robust framework for trauma vitality determination in challenging postmortem contexts. In the future, by further simplifying the complexity of the method and integrating forensic examination comprehensive analysis, this method has promising applications in forensic investigations requiring vitality assessment with differentiation of antemortem from postmortem injury, including after extended postmortem intervals.
区分死前和死后的机械损伤是法医病理学的一个关键挑战,特别是考虑到对严重自溶或腐烂的尸体缺乏可靠的诊断标记。这项研究开创了一种综合方法,结合了先进的形态学表征、红外光谱和化学计量学模型,以识别区分死前和死后创伤的分子特征。光谱分析揭示了与蛋白质(1643 cm−1和1560 cm−1)、磷脂(1402 cm−1)和碳水化合物复合物(1011 cm−1)相关的不同生物标志物模式。这些分子指纹在创伤活力评估中显示出显著的鉴别潜力。通过系统的模式识别,我们开发了优化的偏最小二乘判别分析(PLS-DA)模型,在交叉验证和外部验证队列中都获得了更高的分类精度。建立的方案显示了三个关键优势:在高级分解状态下提高诊断可靠性,通过化学计量处理进行定量光谱解释,以及延长尸检间隔的方法标准化。这种多模式的方法解决了一个持续的法医限制,为在具有挑战性的死后环境中确定创伤活力提供了一个科学可靠的框架。未来,通过进一步简化方法的复杂性,结合法医检验综合分析,该方法在需要区分死前和死后损伤的活力评估的法医调查中,包括延长死后时间的法医调查中,具有广阔的应用前景。
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引用次数: 0
Is self-immolation still a contemporary phenomenon? Forensic evidence from the case studies of Milan (Italy) and literature review 自焚仍然是当代现象吗?来自米兰(意大利)案例研究和文献综述的法医证据
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-29 DOI: 10.1016/j.jflm.2025.102985
Stefano Tambuzzi , Guendalina Gentile , Michele Boracchi , Ranjit Immanuel James , Raffaella Calati , Riccardo Zoja
Self-immolation is one of the most extreme methods of suicide and is characterized by an extremely varied framework, with different profiles of forensic and psychopathological relevance in different areas of the world. It can underline social, cultural, religious, protest motivations or develop in the context of psychiatric pathologies and mental alterations. In this context, cases of suicide by self-immolation that occurred between 2017 and 2024 in Milan (Italy) were analyzed and compared with an earlier study from 1993 to 2016 in the same geographical area. Almost a decade has passed since then, society has experienced periods of major crisis, including the Covid 19 pandemic, and migration flows have increased. Suicide by self-immolation appears to be a slightly increasing phenomenon (+18 % compared to the past), confirming a greater involvement of men in particular, but with a prevalence in an older decade (70–79 years compared to 50–59 years). Furthermore, the number of foreigners has quadrupled (31 % compared to 3 %). In 77 % of the cases, they were subjects suffering from psychiatric pathologies and the main reasons given were attributed to mental health problems, family disputes, sentimental, economic problems and existential distress. There was no motivation attributable to religious, cultural or political reasons. In our view, suicidal burns should be considered a mental health issue in the vast majority of cases. The pathological-forensic starting point has thus made it possible to identify further elements that contribute to the enrichment of knowledge about this phenomenon, which is still relevant in the current society.
自焚是最极端的自杀方法之一,其特点是框架极其多样,在世界不同地区具有不同的法医和精神病理学相关性。它可以强调社会、文化、宗教、抗议动机或在精神病理和精神改变的背景下发展。在此背景下,对2017年至2024年在意大利米兰发生的自焚自杀案件进行了分析,并与1993年至2016年在同一地理区域进行的早期研究进行了比较。自那时以来已经过去了近十年,社会经历了包括Covid - 19大流行在内的重大危机时期,移民流动有所增加。自焚自杀似乎是一种略有增加的现象(与过去相比增加了18%),证实了尤其是男性的更多参与,但流行于年龄较大的10岁(70-79岁,而不是50-59岁)。此外,外国人的数量翻了两番(31%比3%)。在77%的案例中,他们患有精神疾病,给出的主要原因是精神健康问题、家庭纠纷、情感、经济问题和生存困境。没有可归因于宗教、文化或政治原因的动机。我们认为,在绝大多数情况下,自杀性烧伤应被视为精神健康问题。因此,病理学-法医学的出发点使得有可能确定有助于丰富关于这一现象的知识的进一步因素,这在当前社会中仍然是相关的。
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引用次数: 0
Exploration of “out of hours” calls to the Child and Adolescent Sexual Assault Treatment Service in Galway over a one-year period to quantify need for continued extended hours service 探索戈尔韦儿童和青少年性侵犯治疗服务在一年期间的“非工作时间”电话,以量化持续延长服务时间的需求。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-25 DOI: 10.1016/j.jflm.2025.102978
Erica Lahoud , Joanne Nelson , Cathy Bergin
<div><h3>Introduction</h3><div>The Galway Child and Adolescent Sexual Assault Treatment Service (CASATS) operates within a Barnahus model on site on weekdays from 08.00 to 16.00 h with 24/7/365 out of hours on call availability. The service is localised to West and Mid-West Ireland for “in hours” examinations but covers the whole of Southern Ireland for “out of hours” examinations. Whilst CASATS supports children under 18 years of age, “out of hours” forensic medical examinations (FME) are predominantly children under 14 years of age as the adult sexual assault treatment units (SATU) in Ireland offer acute FME to patients from 14 years up. The overlapping 14–18 age group between adult SATU and CASATS makes commissioning challenging. Service specifications in Ireland recommend working towards provision of a 12/7 (08.00–20.00 h) service for paediatric FME, but do not detail recommendations for “out of hours” care for children under 14 years after 20.00 h. This review sought to quantify the number of “out of hours” telephone queries from professionals exploring the need for a paediatric FME for suspected sexual harm and the number of children subsequently examined “out of hours” by Galway CASATS in 2024 to determine the need for a continued extended hours service. “Out of hours” included Saturdays, Sundays, bank or public holidays and between 16.00 and 08.00 on weekdays.</div></div><div><h3>Methods</h3><div>Data were collected anonymously through retrospective review of medical notes and from records of telephone queries received from January 01, 2024 to December 31, 2024. Inclusion criteria were <em>(a)</em> All telephone queries to Galway CASATS (“in” and “out of hours”) relating to the need for FME in children (<18 years) where sexual harm had been disclosed, witnessed or strongly suspected <em>(b)</em> All “in” and “out of hours” FMEs undertaken in Galway CASATS for children (<18 years) including those where agreement had been reached that FME would be beneficial, following discussion (“in hours”) at Barnahus West Interagency planning meetings. Exclusion criteria were <em>(i)</em> Children for whom FME was not indicated, following “in hours” interagency Barnahus discussion <em>(ii)</em> The 41 Children 14–18 years in 2024 supported through the adult sexual assault treatment units, all eligible for Barnahus support.</div></div><div><h3>Results</h3><div>The number of telephone queries and requests for FME arising from Barnahus West in 2024 related to 126 children. Thirty-eight telephone queries concerning 42 children were received outside of Galway CASATS’ normal workday of 08.00–16.00 h. Seventeen calls concerning 20 children were received outside the 08.00–20.00 h 12/7 paediatric FME service specifications for Ireland. Of the 93 children who attended for FME in Galway CASATS in 2024, 19 (19/93 = 20 %) required urgent “out of hours” examination (outside of 08:00–16:00 Monday to Friday workweek) of whom 5 (5/93 = 5 %) required examination ou
简介:高威儿童和青少年性侵犯治疗服务(CASATS)以Barnahus模式在工作日从08:00到16:00在现场运营,24/7/365全天候待命。该服务仅限于爱尔兰西部和中西部的“小时内”考试,但覆盖整个爱尔兰南部的“小时外”考试。虽然CASATS为18岁以下的儿童提供支持,但“非工作时间”法医检查主要针对14岁以下的儿童,因为爱尔兰的成人性侵犯治疗单位(SATU)为14岁以上的患者提供急性法医检查。成人SATU和CASATS之间14-18岁年龄组的重叠使得调试具有挑战性。爱尔兰的服务规范建议为儿科FME提供12/7(08.00-20.00小时)服务。但没有详细说明对20小时后14岁以下儿童的“非工作时间”护理的建议。该审查试图量化“非工作时间”电话查询的数量,这些电话查询来自专业人员,探讨是否需要儿科FME治疗涉嫌性伤害,以及高威CASATS随后在2024年“非工作时间”检查的儿童数量,以确定是否需要继续延长服务时间。“非工作时间”包括星期六、星期日、银行或公众假期,以及平日的16:00至08:00。方法:通过对2024年1月1日至2024年12月31日的病历和电话询问记录进行匿名回顾性调查。纳入标准为(a)所有与儿童FME需求相关的高威CASATS电话查询(“在”和“下班时间”)。(结果:2024年来自Barnahus West的126名儿童的电话查询和FME请求数量。在高威CASATS的正常工作日(08.00- 16:00)之外,收到了涉及42名儿童的38个电话询问。在爱尔兰12/7儿科FME服务规范(08.00-20.00)之外,收到了涉及20名儿童的17个电话。在高威CASATS 2024年参加FME的93名儿童中,19名(19/93 = 20%)需要紧急“非工作时间”考试(周一至周五工作日08:00-16:00以外),其中5名(5/93 = 5%)需要在爱尔兰12/7儿科FME服务规范08.00-20.00以外进行考试。2024年,在戈尔韦CASATS,所有19名需要紧急“非工作时间”FME的儿童都不满14岁。结论:本综述支持继续为14岁以下儿童性侵犯的FME提供24/7/365随叫随到服务的需求。目前的高威CASATS服务不会立即改变,审查结果将提交给国家委员会,以支持持续延长服务时间的提供。
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引用次数: 0
Public prosecutors' perspectives on forensic medical information in non-fatal injury cases in the Netherlands: practices, barriers and recommendations 荷兰检察官对非致命伤害案件中法医信息的看法:做法、障碍和建议。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-24 DOI: 10.1016/j.jflm.2025.102976
Maartje L. Goudswaard , Joyce N. Cuijpers , Manon Ceelen , Solange M. Hoogerheide , Udo J.L. Reijnders , H. Ibrahim Korkmaz , Dionne S. Kringos
Public prosecutors in the Netherlands play a crucial role in ensuring that criminal cases are supported by evidence. This study surveyed public prosecutors to examine current practices, barriers, and recommendations related to the use and availability of forensic medical reports in cases involving non-fatal injuries, including the use of injury dating.
Twelve prosecutors with specific injury-related expertise from 8 out of the 10 police regions completed the online survey. Medical information was viewed as contributing to criminal law proceedings. Forensic medical information was considered particularly important in serious cases such as severe abuse, attempted manslaughter, sexual assault, and domestic violence. Information from treating physicians specifically in cases involving permanent injuries or repeated incidents, especially in the context of domestic violence. However, use of the latter was often limited by concerns about quality, completeness, and accessibility.
Key barriers included time constraints, a shortage of forensic doctors, unclear procedures within the police, privacy concerns among treating physicians, and limited awareness among prosecutors. To address these issues, prosecutors emphasized the need for improved training, the appointment of specialized personnel, stronger interdisciplinary collaboration, and the development of clear procedural guidelines.
In conclusion, this study offers concrete recommendations to enhance the integration of forensic medical expertise into criminal proceedings, contributing to a more effective, efficient, and equitable judicial process.
荷兰的检察官在确保刑事案件有证据支持方面发挥着关键作用。这项研究调查了检察官,以审查在涉及非致命伤害的案件中使用和提供法医报告的现行做法、障碍和建议,包括使用伤害日期测定法。在全国10个警区中,有8个警区的12名检察官完成了在线调查。医疗信息被视为有助于刑事诉讼。在严重虐待、过失杀人未遂、性攻击和家庭暴力等严重案件中,法医信息被认为特别重要。治疗医生提供的资料,特别是涉及永久性伤害或重复事件的案件,特别是在家庭暴力的情况下。然而,后者的使用经常受到质量、完整性和可访问性的限制。主要障碍包括时间限制、法医短缺、警方内部程序不明确、治疗医生对隐私的担忧以及检察官的认识有限。为了解决这些问题,检察官强调需要改进培训、任命专门人员、加强跨学科合作和制定明确的程序准则。最后,本研究提出了具体建议,以加强将法医专业知识纳入刑事诉讼,促进更有效、更高效和更公平的司法程序。
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引用次数: 0
Atypical gunshot injuries: A review of case reports and case series 非典型枪伤:病例报告和病例系列回顾。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-24 DOI: 10.1016/j.jflm.2025.102981
Alok Atreya , Bijeta Pokharel , Dipika Khadka , Prerana Basnet , Sharmila Gurung , Neelu Hirachan , Ritesh G. Menezes

Background and aim

Gunshot injuries are important public health concerns that contribute significantly to disability and mortality, but atypical cases remain underexplored. This review synthesizes the published literature to identify factors that experts/authors use to classify gunshot injuries as atypical, intending to deepen insights and improve forensic interpretations and clinical outcomes.

Methods

Following a scoping review framework, we searched PubMed using keywords related to the terms “atypical,” “gunshot,” and “case report.” We included peer-reviewed case reports and case series in English with no date restrictions. We excluded reviews, typical injury studies, animal studies, and non-English publications. Data were extracted into an Excel spreadsheet to identify patterns in injury characteristics and forensic/clinical implications.

Results

From the 390 records identified, 237 records spanning 1977–2024 were analyzed after screening. Cases were predominantly concentrated in North America and Europe. The classifications of atypical entities fall into four main categories or themes: unusual anatomical locations, aberrant wound patterns, unconventional weapons or ammunition, and unanticipated clinical presentations or complications and unique treatment.

Conclusions

These findings challenge standard ballistic and clinical assumptions and emphasize the need for enhanced forensic tools and individualized treatment approaches in the management of such patients. This scoping review addresses a critical gap by providing forensic experts with better interpretation frameworks and clinicians with refined care strategies.
背景和目的:枪伤是造成残疾和死亡的重要公共卫生问题,但非典型病例仍未得到充分研究。本综述综合了已发表的文献,以确定专家/作者用于将枪伤分类为非典型的因素,旨在加深见解,改善法医解释和临床结果。方法:根据范围审查框架,我们使用与“非典型”、“枪击”和“病例报告”相关的关键词搜索PubMed。我们纳入了同行评议的病例报告和英文病例系列,没有日期限制。我们排除了综述、典型损伤研究、动物研究和非英语出版物。数据被提取到Excel电子表格中,以确定损伤特征和法医/临床意义的模式。结果:从鉴定的390份记录中,筛选后分析了1977-2024年期间的237份记录。病例主要集中在北美和欧洲。非典型实体的分类分为四个主要类别或主题:不寻常的解剖位置,异常的伤口模式,非常规的武器或弹药,意外的临床表现或并发症和独特的治疗。结论:这些发现挑战了标准的弹道和临床假设,并强调需要加强法医工具和个性化治疗方法来管理这类患者。这一范围审查通过为法医专家提供更好的解释框架和临床医生提供完善的护理策略,解决了一个关键的差距。
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引用次数: 0
Infant life-threatening accidental head injury from 45 cm fall causing traumatic dissecting aneurysm and delayed rebleeding 婴儿从45厘米高处跌落造成创伤性夹层动脉瘤和迟发性再出血,危及生命
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-23 DOI: 10.1016/j.jflm.2025.102983
Catherine Skellern , Michael Stuart
Whilst short falls within the home are a common cause for infants under 12 months to present to hospital emergency departments, serious injuries or fatalities are exceptionally rare. Forensic evaluation of injuries is essential and considers a range of factors ascertained from investigation of the circumstances alongside findings from medical evaluations to consider injury plausibility. We report a case of a rare mechanism involving occipital-cervical distraction causing cerebrovascular dissection of the posterior inferior cerebellar artery and delayed rebleeding following a verified short distance fall of 45 cm from a sofa to highlight factors that assist in timely recognition of this injury which can be life-threatening or even fatal if overlooked.
虽然家中失足是12个月以下婴儿到医院急诊科就诊的常见原因,但严重受伤或死亡的情况极为罕见。对伤害的法医评估至关重要,并考虑从调查情况中确定的一系列因素以及医疗评估的结果,以考虑伤害的合理性。我们报告了一个罕见的机制,涉及枕颈牵张导致小脑后下动脉的脑血管夹层,并在经过验证的从沙发上跌落45厘米后延迟再出血,以强调有助于及时识别这种损伤的因素,如果忽视,这种损伤可能危及生命甚至致命。
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引用次数: 0
An autopsy case of eosinophilic coronary periarteritis with coronary arterial degeneration and repaired dissection 嗜酸性冠状动脉周围炎伴冠状动脉变性及修复性夹层尸检1例。
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-22 DOI: 10.1016/j.jflm.2025.102977
Hidenori Yoshizawa , Yoshihiko Ikeda , Eiich Morii , Kinta Hatakeyama
Eosinophilic coronary periarteritis (ECPA) is a rare disease, almost exclusively diagnosed postmortem, characterized by a clinical course of vasospastic angina (VSA) attacks and histologically observed periarterial eosinophilic infiltration in the coronary arteries. Although the etiology of ECPA remains uncertain, its pathogenesis may be attributed to an allergic reaction. In addition, ECPA is often associated with spontaneous coronary artery dissection (SCAD); however, the pathogenesis underlying the link between inflammation and dissection remains unclear.
In the current case, a 45-year-old female experienced VSA attacks and succumbed to a fatal exacerbation of VSA approximately six years after the first onset of symptoms. Pathological examination at autopsy revealed periarterial eosinophilic infiltration in the coronary artery, suggesting ECPA. Characteristically, the pathological findings further showed localized SCAD with a repair response and deposition of a degenerative matrix in the tunica media. These findings may provide insights into the pathogenesis of ECPA.
This case highlights the importance of autopsy examinations for discussing and elucidating the pathophysiology of ECPA.
嗜酸性冠状动脉周围炎(ECPA)是一种罕见的疾病,几乎都是在死后诊断出来的,其临床特征是血管痉挛性心绞痛(VSA)发作,组织学上观察到冠状动脉动脉周围嗜酸性粒细胞浸润。虽然ECPA的病因尚不清楚,但其发病机制可能归因于过敏反应。此外,ECPA常伴有自发性冠状动脉夹层(SCAD);然而,炎症和夹层之间的发病机制尚不清楚。在本病例中,一名45岁女性经历了VSA发作,并在首次出现症状约6年后死于VSA致命恶化。尸检病理检查显示冠状动脉动脉周围嗜酸性粒细胞浸润,提示ECPA。典型的是,病理结果进一步显示局部SCAD具有修复反应和在中膜中沉积退行性基质。这些发现可能为ECPA的发病机制提供新的见解。本病例强调解剖检查对讨论和阐明ECPA病理生理的重要性。
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引用次数: 0
Comparison of the accuracy of two different methods in dental age estimation 两种牙龄估算方法的准确性比较
IF 1.2 4区 医学 Q3 MEDICINE, LEGAL Pub Date : 2025-09-22 DOI: 10.1016/j.jflm.2025.102980
Merve Kucuk Kurtgoz, Zarif Ece Hammudioglu, Elif Cecen Erol, Ceren Aktuna Belgin

Introduction

Age estimation plays a crucial role in forensic medicine, particularly in countries facing significant refugee-related challenges. There are many parameters used for age estimation. The aim of this study is to evaluate the visibility of the pulp and periodontal ligament space in the mandibular third molar using cone beam computed tomography (CBCT) images and to compare the effectiveness of these two methods in chronological age estimation, specifically in assessing the 18–21 age thresholds.

Method

CBCT images of 359 patients (189 females, 170 males), aged between 16 and 29 were analyzed by three independent observers. Patients with a history of trauma and/or surgery in the maxillofacial region, developmental anomalies or pathologies in the mandible, or systemic diseases affecting growth and development were excluded. Additionally, third molars with incomplete root development, developmental or acquired dental anomalies, pulp calcification etc. were excluded from the study. After recording the patients' age and sex, the mandibular third molars were classified according to the Olze (visibility of the root pulp) and Guo classification (visibility of the periodontal ligament) into grades 0, 1, 2, and 3. Each observer re-evaluated the CBCT images of 140 randomly selected patients two weeks later to assess intra-observer reliability.

Results

The simple correlations between Olze and Guo grades were examined regardless of sex, the relationship between both methods and age was found to be significant and positive (Olze vs age r = 0.493 and p < 0.001, Guo vs age r = 0.445 and p < 0.001). Additionally, for both the Olze and Guo methods, it was observed that as the grade increased, mean age also increased at a statistically significant level (p < 0.001). Olze and Guo's grades changed statistically significantly in the 18 and 21 age thresholds in total (p < 0.001). When both methods were evaluated on a grade basis, it was seen that both Olze and Guo grade 0 increased statistically significantly in the under-18 age group, while Olze Grade 1 and Grade 2, and Guo Grade 2 increased statistically significantly in the 18 and over age group (p < 0.001). Olze method's cutoff value was found to be > 0, and Guo method's cutoff value was found to be > 1 in distinguishing between those under 18 and over. Both Olze and Guo's methods were found to be more successful in predicting the 18-year-old threshold.

Conclusion

Although they offer a high probability of being accurate, both Olze and Guo classifications do not provide 100 % accuracy in determining the 18 and 21 age thresholds in forensic dental age estimation. However, for both the Olze and Guo methods, the mean age increased as the grade increased. Both the Olze and Guo methods were found to be successful in estimating the 18 and 21 age thresholds.
年龄估计在法医中起着至关重要的作用,特别是在面临与难民有关的重大挑战的国家。有许多参数用于年龄估计。本研究的目的是利用锥形束计算机断层扫描(CBCT)图像评估下颌第三磨牙牙髓和牙周韧带间隙的可见性,并比较这两种方法在实际年龄估计方面的有效性,特别是在评估18-21岁的年龄阈值方面。方法对年龄16 ~ 29岁的359例患者(女性189例,男性170例)的cbct图像进行分析。排除有外伤和/或颌面手术史、下颌骨发育异常或病理、或影响生长发育的全身性疾病的患者。此外,有牙根发育不全、发育或获得性牙畸形、牙髓钙化等情况的第三磨牙也被排除在研究之外。记录患者的年龄和性别后,根据Olze(根髓可见性)和Guo(牙周韧带可见性)将下颌第三磨牙分为0、1、2、3级。每个观察者在两周后重新评估140名随机选择的患者的CBCT图像,以评估观察者内部的可靠性。结果不论性别,Olze评分与Guo评分之间均存在简单相关,两种方法与年龄之间均存在显著正相关(Olze与年龄r = 0.493, p < 0.001; Guo与年龄r = 0.445, p < 0.001)。此外,对于Olze和Guo方法,观察到随着等级的增加,平均年龄也在统计学显著水平上增加(p < 0.001)。Olze和Guo的成绩在18岁和21岁的总阈值上有显著的统计学差异(p < 0.001)。当两种方法以年级为基础进行评估时,发现18岁以下年龄组Olze和Guo 0级评分均有统计学意义升高,18岁及以上年龄组Olze 1级、2级评分和Guo 2级评分均有统计学意义升高(p < 0.001)。在区分18岁以下和18岁以上人群时,发现Olze法的截止值为>; 0, Guo法的截止值为>; 1。研究发现,Olze和Guo的方法在预测18岁阈值方面更为成功。结论虽然Olze分类和Guo分类的准确率很高,但在法医牙龄估计中,18岁和21岁的年龄阈值的确定并非100%准确。然而,对于Olze和Guo方法,平均年龄随着等级的增加而增加。Olze和Guo的方法在估计18岁和21岁的年龄阈值方面都是成功的。
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引用次数: 0
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Journal of forensic and legal medicine
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