Fatal asphyxia is one of the most diagnostically complex categories of sudden death because its macroscopic signs are often subtle, heterogeneous and easily confounded with post-mortem artefacts. We reviewed 38 English-language publications (2000–2025) that contained autopsy-confirmed asphyxial fatalities and re-coded every case into a five-group typology—mechanical, electrical, toxic (chemical), ambient-hypoxia and pathological (endogenous). Recurrent external findings, internal soft-tissue lesions and ancillary toxicological or histochemical markers were extracted, and the literature trends were anchored to day-to-day practice by a single illustrative non-homicidal thoracocervical-compression case from our regional medicolegal institute. Within the pooled dataset, neck compression accounted for 55 % of mechanical fatalities, yet petechial haemorrhages were absent in 38 % of those victims, and potential toxicological co-factors (ethanol, opioids or sedatives) were documented in almost one-third of all cases. These discrepancies expose blind spots in death-scene reconstruction and in the routine dissection of deep cervical tissues. Accordingly, we propose a pragmatic classification framework that forces explicit consideration of scene context, mandates layer-by-layer dissection of the neck and anterior thorax, and incorporates targeted toxicology to resolve ambiguous mechanisms. By integrating narrative evidence with real-world autopsy experience, the review delineates where current diagnostic protocols succeed and where they fail, providing forensic pathologists with a clearer decision pathway when evaluating suspected asphyxial deaths.
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