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Physiological Significance of Oxidized Cholesterols 氧化胆固醇的生理意义
Pub Date : 2012-01-01 DOI: 10.5650/OLEOSCIENCE.12.115
Masao Sato, Bungo Shirouchi
About 3,000 reports on oxidized cholesterols were published until 2011. Oxidized cholesterols are related to development of several diseases. Their physiological significance is as following; (1) interference of synthesis and/or action of steroid hormones, (2) intermediates in bile acids synthesis, (3) promotion or suppression of development of atherosclerosis, (4) ligands for LXR, (5) suppression of de novo cholesterol synthesis, (6) intermediates of cholesterol metabolism in the brain, and (7) disrupters of lipid metabolism by dietar y oxidized cholesterols. In order to grasp these phenomena, there has to be a better way to analyze oxidized cholesterols in vivo with accuracy.
直到2011年,大约有3000份关于氧化胆固醇的报告发表。氧化胆固醇与多种疾病的发生有关。其生理意义如下:(1)干扰类固醇激素的合成和/或作用,(2)胆汁酸合成的中间体,(3)促进或抑制动脉粥样硬化的发展,(4)LXR的配体,(5)抑制新生胆固醇合成,(6)脑内胆固醇代谢的中间体,(7)通过饮食氧化胆固醇干扰脂质代谢。为了掌握这些现象,必须有一种更好的方法来准确地分析体内氧化胆固醇。
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引用次数: 2
The State of the Art and Perspective of Structural Study on Skin Stratum Cormeum 皮肤角质层结构研究的现状与展望
Pub Date : 2012-01-01 DOI: 10.5650/oleoscience.12.25
I. Hatta
: Based upon the wide q -range X-ray scattering study on stratum corneum, I will introduce that not only the structure of the intercellular lipid matrix but also the structure of soft keratin in the corneocytes plays an important role in function of the stratum corneum.
基于对角质层的宽q范围x射线散射研究,我将介绍除了细胞间脂质基质的结构外,角质层中软角蛋白的结构在角质层的功能中也起着重要的作用。
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引用次数: 1
Gemini Surfactant : その化学構造と界面物性 Gemini Surfactant:它的化学结构和界面物性
Pub Date : 2011-09-01 DOI: 10.5650/OLEOSCIENCE.11.313
Tatsuo Oida, H. N. Chau
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引用次数: 5
ポーラーパラドックス (Polar Paradox) について 关于葆拉悖论(Polar Paradox)
Pub Date : 2011-08-01 DOI: 10.5650/OLEOSCIENCE.11.283
和夫 宮下
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引用次数: 0
Interaction Forces between Solid Surfaces in Non-aqueous Solutions 非水溶液中固体表面间的相互作用力
Pub Date : 2011-01-01 DOI: 10.5650/OLEOSCIENCE.11.235
K. Higashitani
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引用次数: 1
Experimental Investigation of the Interaction Forces between Soft Interfaces 软界面相互作用力的实验研究
Pub Date : 2011-01-01 DOI: 10.5650/OLEOSCIENCE.11.79
N. Ishida
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引用次数: 0
Smart Emulsions Stabilized with Polymer Particles 智能乳液稳定与聚合物颗粒
Pub Date : 2009-01-01 DOI: 10.5650/OLEOSCIENCE.9.511
S. Fujii, R. Murakami
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引用次数: 3
Anti-Obesity Effects of Polyunsaturated Fatty Acid 多不饱和脂肪酸的抗肥胖作用
Pub Date : 2009-01-01 DOI: 10.5650/OLEOSCIENCE.9.423
S. Meguro, I. Tokimitsu
Polyunsaturated-fatty-acids have different physiological effects depending on the number and position of a double bond exists within the representative molecule, and the difference of acyl-chain length. According to the anti-obesity effects of polyunsaturated-fatty-acids, there are many researches with conjugated-fatty-acids (particularly conjugated-linoleic-acid) and n-3 polyunsaturated-fatty-acids (particularly eicosapentaenoic-acid, docosahexaenoic-acid, or fish oil which contains these fatty acids), which are conducted about the anti-obesity potentials and the mechanisms, possible effects on energy expenditure, lipid metabolism and so on, in cells, animals, and humans. In this review, we focus on conjugated-fatty-acids and n-3 polyunsaturated-fatty-acids in anti-obesity effects, and summarize of the potential of efficacy and possible mechanisms with recent reports.
多不饱和脂肪酸的生理作用取决于代表分子内双键的数目和位置,以及酰基链长度的不同。根据多不饱和脂肪酸的抗肥胖作用,人们对共轭脂肪酸(特别是共轭亚油酸)和n-3多不饱和脂肪酸(特别是含有这些脂肪酸的二十碳五烯酸、二十二碳六烯酸或鱼油)在细胞、动物和人体中的抗肥胖潜力、机制、对能量消耗、脂质代谢等可能产生的影响进行了大量的研究。本文就共轭脂肪酸和n-3多不饱和脂肪酸的抗肥胖作用作一综述,并结合近期报道对其潜在的抗肥胖功效和可能的机制进行综述。
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引用次数: 0
Why Does the Cat Eat a Fish? : The Hypothesis is Based on Lipid Nutrition 猫为什么吃鱼?:假设是基于脂质营养
Pub Date : 2009-01-01 DOI: 10.5650/OLEOSCIENCE.9.443
H. Hibino
Arachidonic acid, retinol and taurine are known to the cat : felis catus of the genuine flesh-eating animal as nutrient necessity. The required nature of the arachidonic acid depends on deficit of A6-desaturase. Therefore arachidonic acid cannot metabolize even if cat take in linoleic acid. Because the required nature of the retinol (vitamin A) deletes dioxygenase in the bowels, cat cannot resolve /3-carotene into retinol. Because cat do not have an enzyme composing taurine, it is necessary to take in the taurine which there is only to animal protein. It mean that EPA and DHA cannot metabolize even if the deficit of A6-desaturase takes in the linolenic acid of the n-3 fatty acid. It is necessary to take in the mammalian meat which contains them because it cannot metabolize even if the cat of the genuine flesh-eating animal takes in linoleic acid and the linolenic acid of the plant to get arachidonic acid, EPA and DHA. The fish contains arachidonic acid, retinol, and taurine other than EPA and DHA. The photoreceptor of the retina of the cat which a thing looks like in darkness, DHA, retinol and taurine are that is to say necessary for construction and the maintenance of the photoreceptor. The writer suggests a hypothesis that "the cat eats a fish when it cannot take in meat" from the above-mentioned reason.
花生四烯酸、视黄醇和牛磺酸是猫科动物的营养必需品。花生四烯酸所需的性质取决于a6去饱和酶的缺乏。因此,即使猫摄入亚油酸,花生四烯酸也不能代谢。因为必需的视黄醇(维生素A)会在肠道中删除双加氧酶,猫不能将/3-胡萝卜素分解成视黄醇。由于猫体内没有一种构成牛磺酸的酶,所以有必要摄取牛磺酸,而牛磺酸只有一种动物蛋白。这意味着即使a6去饱和酶的缺陷吸收了n-3脂肪酸的亚麻酸,EPA和DHA也不能代谢。真正的食肉动物的猫即使摄入了植物的亚油酸和亚麻酸,也不能代谢得到花生四烯酸、EPA和DHA,所以有必要摄取含有这些物质的哺乳动物的肉。除了EPA和DHA,鱼还含有花生四烯酸、视黄醇和牛磺酸。猫视网膜上的光感受器在黑暗中,DHA,视黄醇和牛磺酸是构建和维持光感受器所必需的。作者根据上述原因提出了“猫吃不到肉就吃鱼”的假设。
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引用次数: 0
Synthesis and Function of Polymer Soft Nanocapsules via Precision Polymerization 精密聚合法制备高分子软纳米胶囊及其功能研究
Pub Date : 2009-01-01 DOI: 10.5650/OLEOSCIENCE.9.211
S. Sugihara
The field of soft nanocapsules prepared via precision polymerization is briefly reviewed. The recent development of precision polymerization has provided us with versatile tools for synthesis of wide range of functional block copolymers with well-defined structure. The molecular dimensions influence the self-assembly and dictate their products such as nanoparticles and nanocapsules. In this review, general nanoparticles, which are classified 3 types such as homogeneous, core-shell, and hybridtype, were first described briefly. In the next place, the recent development of shell cross-linked micelles, namely SCK micelles, including in our results are focused on as a typical example of the coreshell typed nanoparticles. This shell cross-linked design leads to numerous potential applications in encapsulation, drug delivery, templating, nanoreacter, and many other.
综述了精密聚合法制备纳米软胶囊的研究进展。近年来精密聚合技术的发展为我们合成结构明确的功能嵌段共聚物提供了多种多样的工具。分子尺寸影响自组装,并决定其产物,如纳米颗粒和纳米胶囊。本文首先对均相纳米粒子、核壳型纳米粒子和杂交型纳米粒子进行了综述。在接下来的地方,最近的发展壳交联胶束,即SCK胶束,包括在我们的结果集中作为核壳型纳米粒子的典型例子。这种壳交联设计在封装、药物输送、模板化、纳米反应器和许多其他领域有许多潜在的应用。
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引用次数: 0
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Journal of Japan Oil Chemists Society
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