首页 > 最新文献

Journal of NeuroEngineering and Rehabilitation最新文献

英文 中文
Overground robotic walker use in the home and community: a six-month prospective cohort study. 在家庭和社区使用的地面机器人行走器:一项为期六个月的前瞻性队列研究。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-13 DOI: 10.1186/s12984-025-01812-8
Alicia J Hilderley, Christa M Diot, Hua Shen, Sean P Dukelow, Kelly A Larkin-Kaiser, Adam Kirton, Elizabeth G Condliffe

Background: Outcomes following long-term use of overground robotic walkers have not been studied, even though children with mobility impairments are using these devices for extended periods. We aimed to evaluate the impacts of six months of overground robotic walker use in the home and community.

Methods: An observational cohort study was conducted with a volunteer sample of 171 participants with mobility impairments who privately obtained an overground robotic walker. Participant-initiated overground robotic walker use in the home and community was evaluated over six-months. The primary outcome of functional ability was assessed by parent report using the Gillette Functional Assessment Questionnaire (FAQ). Secondary outcome measures were parent-reported physical activity, positive affect, sleep disturbance, and bowel movement frequency. Questionnaires were sent digitally at baseline (when users received device use training), and then 1-Month, 3-Months and 6-Months later. The device tracked monthly usage, specifically number of steps, minutes of use, average cadence (steps/minute), and the number of times the device was used.

Results: Median participant age was 6 years (range 1 to 24), 42.1% were female, 70.8% had a diagnosis of cerebral palsy, and most were not independently ambulatory (97.3% of participants who reported function). Adjusted cumulative link mixed models demonstrated a significant main effect of time for FAQ scores, with increased log odds of a higher FAQ score at each time point (ß=0.86, 95% CI [0.25, 1.46], p = 0.006). The median FAQ score increased from 1 at baseline to 2 at subsequent time points. Adjusted repeated measures linear mixed-effects models demonstrated significant main effects of time for secondary outcomes, with improvements in physical activity scores (ß=0.96, 95% CI [0.21, 1.71], p = 0.012), sleep disturbance scores (ß=-0.82, 95% CI [-1.61, -0.04], p = 0.040), average cadence (steps/minute) (ß=1.86, 95% CI [0.61, 3.11], p = 0.004), and also decreases in the number of times the device was used per month (ß=-0.95, 95% CI [-1.63, -0.26], p = 0.007). Device usage time and total steps per month did not significantly change over time.

Conclusions: Six months of overground robotic walker use resulted in modest, statistically significant improvements in functional ability and secondary outcomes linked to physical inactivity. Device usage time was consistent over time, suggesting feasibility of long-term home and community use.

背景:长期使用地面机器人行走器的结果尚未研究,即使有行动障碍的儿童长时间使用这些设备。我们的目的是评估在家庭和社区使用六个月的地面机器人行走器的影响。方法:对171名有行动障碍的志愿者样本进行了一项观察性队列研究,他们私下获得了一个地上机器人行走器。在六个月的时间里,研究人员对参与者在家庭和社区中主动使用的地面机器人行走器进行了评估。功能能力的主要结局由家长报告评估,使用吉列功能评估问卷(FAQ)。次要结局指标是父母报告的身体活动、积极影响、睡眠障碍和排便频率。问卷在基线时(当用户接受设备使用培训时)以数字方式发送,然后在1个月,3个月和6个月后发送。该设备跟踪每月的使用情况,特别是步数、使用分钟数、平均节奏(步数/分钟)和设备的使用次数。结果:参与者年龄中位数为6岁(范围1至24岁),42.1%为女性,70.8%诊断为脑瘫,大多数不能独立走动(97.3%的参与者报告有功能)。调整后的累积链接混合模型显示时间对FAQ得分有显著的主效应,每个时间点FAQ得分越高的对数赔率越高(ß=0.86, 95% CI [0.25, 1.46], p = 0.006)。中位FAQ得分从基线的1分增加到随后时间点的2分。调整后的重复测量线性混合效应模型显示,时间对次要结果有显著的主要影响,包括体力活动评分(ß=0.96, 95% CI [0.21, 1.71], p = 0.012)、睡眠障碍评分(ß=-0.82, 95% CI [-1.61, -0.04], p = 0.040)、平均步频(步数/分钟)(ß=1.86, 95% CI [0.61, 3.11], p = 0.004)的改善,以及每月使用设备次数的减少(ß=-0.95, 95% CI [-1.63, -0.26], p = 0.007)。设备使用时间和每月总步数没有随时间发生显著变化。结论:6个月的地面机器人助行器使用导致了适度的、统计学上显著的功能能力改善和与缺乏身体活动相关的次要结果。随着时间的推移,设备的使用时间是一致的,这表明长期家庭和社区使用的可行性。
{"title":"Overground robotic walker use in the home and community: a six-month prospective cohort study.","authors":"Alicia J Hilderley, Christa M Diot, Hua Shen, Sean P Dukelow, Kelly A Larkin-Kaiser, Adam Kirton, Elizabeth G Condliffe","doi":"10.1186/s12984-025-01812-8","DOIUrl":"10.1186/s12984-025-01812-8","url":null,"abstract":"<p><strong>Background: </strong>Outcomes following long-term use of overground robotic walkers have not been studied, even though children with mobility impairments are using these devices for extended periods. We aimed to evaluate the impacts of six months of overground robotic walker use in the home and community.</p><p><strong>Methods: </strong>An observational cohort study was conducted with a volunteer sample of 171 participants with mobility impairments who privately obtained an overground robotic walker. Participant-initiated overground robotic walker use in the home and community was evaluated over six-months. The primary outcome of functional ability was assessed by parent report using the Gillette Functional Assessment Questionnaire (FAQ). Secondary outcome measures were parent-reported physical activity, positive affect, sleep disturbance, and bowel movement frequency. Questionnaires were sent digitally at baseline (when users received device use training), and then 1-Month, 3-Months and 6-Months later. The device tracked monthly usage, specifically number of steps, minutes of use, average cadence (steps/minute), and the number of times the device was used.</p><p><strong>Results: </strong>Median participant age was 6 years (range 1 to 24), 42.1% were female, 70.8% had a diagnosis of cerebral palsy, and most were not independently ambulatory (97.3% of participants who reported function). Adjusted cumulative link mixed models demonstrated a significant main effect of time for FAQ scores, with increased log odds of a higher FAQ score at each time point (ß=0.86, 95% CI [0.25, 1.46], p = 0.006). The median FAQ score increased from 1 at baseline to 2 at subsequent time points. Adjusted repeated measures linear mixed-effects models demonstrated significant main effects of time for secondary outcomes, with improvements in physical activity scores (ß=0.96, 95% CI [0.21, 1.71], p = 0.012), sleep disturbance scores (ß=-0.82, 95% CI [-1.61, -0.04], p = 0.040), average cadence (steps/minute) (ß=1.86, 95% CI [0.61, 3.11], p = 0.004), and also decreases in the number of times the device was used per month (ß=-0.95, 95% CI [-1.63, -0.26], p = 0.007). Device usage time and total steps per month did not significantly change over time.</p><p><strong>Conclusions: </strong>Six months of overground robotic walker use resulted in modest, statistically significant improvements in functional ability and secondary outcomes linked to physical inactivity. Device usage time was consistent over time, suggesting feasibility of long-term home and community use.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"22"},"PeriodicalIF":5.2,"publicationDate":"2025-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145751817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distinct patterns in neuromuscular adaptation to repeated perturbations in chronic ankle instability. 慢性踝关节不稳定中反复扰动的神经肌肉适应的独特模式。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-12 DOI: 10.1186/s12984-025-01838-y
Xiaohan Xu, Joanna Bowtell, William R Young, Daniel T P Fong, Genevieve K R Williams
{"title":"Distinct patterns in neuromuscular adaptation to repeated perturbations in chronic ankle instability.","authors":"Xiaohan Xu, Joanna Bowtell, William R Young, Daniel T P Fong, Genevieve K R Williams","doi":"10.1186/s12984-025-01838-y","DOIUrl":"10.1186/s12984-025-01838-y","url":null,"abstract":"","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"21"},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NeuraLoop: a high bandwidth closed-loop human-machine interface. NeuraLoop:高带宽闭环人机界面。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-12 DOI: 10.1186/s12984-025-01815-5
Luis Pelaez Murciego, Elias Thomassen Dam, Hans Henrik Dalgaard, Nikola Jorgovanovic, Matija Strbac, Erika G Spaich, Strahinja Dosen

Background: Myoelectric interfaces have emerged as powerful tools for human-machine interaction (HMI), enabling intuitive control of virtual and physical devices. However, most existing systems are limited by low spatial resolution and unidirectional communication. To address these limitations, we developed NeuraLoop, a wearable, high-bandwidth, bidirectional interface that integrates myoelectric (EMG) signal acquisition and electrotactile stimulation feedback within a single wearable textile-based platform.

Methods: NeuraLoop comprises a flexible matrix of 32 EMG recording and 32 electrotactile stimulation pads controlled by a compact electronic unit. We evaluated the system in two experimental tasks involving ten healthy subjects to demonstrate: (1) online classification of four transient thumb micro-gestures (thumb rightwards, leftwards, upwards, and downwards swipe directions), and (2) closed-loop control of a virtual cursor using micro-gesture commands and spatially encoded tactile feedback. A time-division multiplexing (TDM) strategy was implemented to enable simultaneous stimulation and recording.

Results: The subjects achieved a median success rate of 82% on the first attempt and over 94% within two attempts during online classification with visual feedback. All four micro-gestures were classified with similar accuracy. In the closed-loop control task with tactile feedback, participants navigated a 3 × 4 grid using only electrotactile stimulation, achieving 70% accuracy for exact target hits and 95% when including the hits in the neighboring cells (1 cell distance error).

Conclusions: NeuraLoop demonstrates the feasibility of high-bandwidth, bidirectional HMI using a wearable, textile-based interface. The system enables accurate recognition of subtle micro-gestures and effective delivery of spatially encoded tactile feedback. These capabilities open new possibilities for intuitive control in applications such as prosthetics, rehabilitation, and virtual/augmented reality. Future work will explore multimodal feedback encoding and proportional gesture control.

背景:肌电界面已经成为人机交互(HMI)的强大工具,可以直观地控制虚拟和物理设备。然而,大多数现有系统都受到低空间分辨率和单向通信的限制。为了解决这些限制,我们开发了NeuraLoop,这是一种可穿戴的、高带宽的双向接口,将肌电(EMG)信号采集和电触觉刺激反馈集成在一个基于纺织品的可穿戴平台上。方法:NeuraLoop由一个由32个肌电记录和32个触电刺激垫组成的柔性矩阵组成,触电刺激垫由一个紧凑的电子单元控制。我们在10名健康受试者的两个实验任务中对该系统进行了评估,以证明:(1)四种瞬态拇指微手势(拇指向右、向左、向上和向下滑动方向)的在线分类,以及(2)使用微手势命令和空间编码触觉反馈对虚拟光标进行闭环控制。采用时分多路复用(TDM)策略,可以同时进行刺激和记录。结果:在视觉反馈的在线分类中,受试者第一次成功率中位数为82%,两次成功率中位数为94%以上。这四种微手势的分类准确率都差不多。在具有触觉反馈的闭环控制任务中,参与者仅使用触觉电刺激导航3 × 4网格,精确命中目标的准确率达到70%,当包括相邻单元的命中时(1单元距离误差),准确率达到95%。结论:NeuraLoop展示了使用可穿戴、基于纺织品的界面实现高带宽、双向人机界面的可行性。该系统能够准确识别细微的微手势,并有效地传递空间编码的触觉反馈。这些功能为假肢,康复和虚拟/增强现实等应用中的直观控制开辟了新的可能性。未来的工作将探索多模态反馈编码和比例手势控制。
{"title":"NeuraLoop: a high bandwidth closed-loop human-machine interface.","authors":"Luis Pelaez Murciego, Elias Thomassen Dam, Hans Henrik Dalgaard, Nikola Jorgovanovic, Matija Strbac, Erika G Spaich, Strahinja Dosen","doi":"10.1186/s12984-025-01815-5","DOIUrl":"10.1186/s12984-025-01815-5","url":null,"abstract":"<p><strong>Background: </strong>Myoelectric interfaces have emerged as powerful tools for human-machine interaction (HMI), enabling intuitive control of virtual and physical devices. However, most existing systems are limited by low spatial resolution and unidirectional communication. To address these limitations, we developed NeuraLoop, a wearable, high-bandwidth, bidirectional interface that integrates myoelectric (EMG) signal acquisition and electrotactile stimulation feedback within a single wearable textile-based platform.</p><p><strong>Methods: </strong>NeuraLoop comprises a flexible matrix of 32 EMG recording and 32 electrotactile stimulation pads controlled by a compact electronic unit. We evaluated the system in two experimental tasks involving ten healthy subjects to demonstrate: (1) online classification of four transient thumb micro-gestures (thumb rightwards, leftwards, upwards, and downwards swipe directions), and (2) closed-loop control of a virtual cursor using micro-gesture commands and spatially encoded tactile feedback. A time-division multiplexing (TDM) strategy was implemented to enable simultaneous stimulation and recording.</p><p><strong>Results: </strong>The subjects achieved a median success rate of 82% on the first attempt and over 94% within two attempts during online classification with visual feedback. All four micro-gestures were classified with similar accuracy. In the closed-loop control task with tactile feedback, participants navigated a 3 × 4 grid using only electrotactile stimulation, achieving 70% accuracy for exact target hits and 95% when including the hits in the neighboring cells (1 cell distance error).</p><p><strong>Conclusions: </strong>NeuraLoop demonstrates the feasibility of high-bandwidth, bidirectional HMI using a wearable, textile-based interface. The system enables accurate recognition of subtle micro-gestures and effective delivery of spatially encoded tactile feedback. These capabilities open new possibilities for intuitive control in applications such as prosthetics, rehabilitation, and virtual/augmented reality. Future work will explore multimodal feedback encoding and proportional gesture control.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"20"},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12817707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inter-segmental coordination patterns in Parkinson's disease are particularly disturbed during preferred walking speed: a data-driven network approach. 帕金森病的节段间协调模式在首选步行速度期间特别受到干扰:数据驱动的网络方法。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-12 DOI: 10.1186/s12984-025-01835-1
Karolina Saegner, Robbin Romijnders, Inga Ruff, Julius Welzel, Clint Hansen, Elke Warmerdam, Pedro Conceição, Walter Maetzler
{"title":"Inter-segmental coordination patterns in Parkinson's disease are particularly disturbed during preferred walking speed: a data-driven network approach.","authors":"Karolina Saegner, Robbin Romijnders, Inga Ruff, Julius Welzel, Clint Hansen, Elke Warmerdam, Pedro Conceição, Walter Maetzler","doi":"10.1186/s12984-025-01835-1","DOIUrl":"10.1186/s12984-025-01835-1","url":null,"abstract":"","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"39"},"PeriodicalIF":5.2,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12849571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development and validation of the electrosacrogram (ESG): a digital point-of-care tool for real-time neuro-sacral assessment after spinal cord injury. 骶电图(ESG)的开发和验证:一种用于脊髓损伤后实时神经-骶骨评估的数字护理点工具。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-11 DOI: 10.1186/s12984-025-01797-4
Maude Duguay, Jean-Marc Mac-Thiong, Juan-David Cifuentes-Hernandez, Natan Bensoussan, Andréane Richard-Denis

Background: Accurate assessment of neuro-sacral function after spinal cord injury/lesion and cauda equina (SCI+) is essential for diagnosis, prognosis and early management. The current bedside standard, the digital rectal examination (DRE), is subjective, invasive, and examiner dependent. Surface electromyography (s-EMG) offers a quantitative alternative but has lacked point-of-care integration. We developed the ElectroSacroGram (ESG), a bedside digital s-EMG tool enabling real-time objective assessment of sacral somatic function after SCI+. This study aimed to (1) develop the ESG protocol based on clinical consensus; and (2) evaluate its diagnostic performance compared to radiological findings and expert-performed DRE.

Methods: In this prospective proof-of-concept diagnostic study at a specialized Level 1 trauma center, 52 adults with suspected SCI + and 21 healthy participants underwent ESG and DRE. ESG quantified sacral motor (resting external anal sphincter tone, maximal voluntary anal contraction (maxVAC), reflex (bulbospongious or bulbocavernosus reflex (BSR)), and sensory (electrical perceptual threshold (EPT)) function using low-intensity electrical stimulation. Clinically relevant DRE parameters were selected by an expert panel. Content validity was assessed using item/scale content validity indices (CVI), agreement with DRE (Cohen's κ) and diagnostic accuracy were calculated against imaging-confirmed spinal lesions.

Results: Normative ESG values were established in healthy participants. Neurologically impaired patients showed reduced maxVAC and BSR amplitudes and elevated EPT. ESG demonstrated excellent content validity (S-CVI = 1.00), strong agreement with DRE for VAC (κ = 0.876) and EPT (κ = 0.881), and high diagnostic accuracy (sensitivity 83.3%, specificity 100%, overall accuracy 86.5%).

Conclusions: ESG enables precise, reproducible evaluation of sacral motor, reflex, and sensory integrity in real-time at bedside. By complementing and objectifying the DRE, it offers a promising precision-medicine tool for early neuro-sacral assessment, enhancing clinical research and improving SCI + diagnosis, for the acute phase and in the context of spinal shock.

背景:准确评估脊髓损伤/病变和马尾(SCI+)后的神经-骶骨功能对诊断、预后和早期治疗至关重要。目前的床边标准,直肠指检(DRE),是主观的,侵入性的,并且依赖于检查者。表面肌电图(s-EMG)提供了一种定量的替代方法,但缺乏点护理整合。我们开发了骶电图(ESG),这是一种床边数字s-EMG工具,可以实时客观地评估SCI+后的骶骨躯体功能。本研究旨在(1)基于临床共识制定ESG方案;(2)将其诊断性能与放射学结果和专家DRE进行比较。方法:在一个专门的一级创伤中心进行的这项前瞻性概念验证诊断研究中,52名疑似SCI +的成年人和21名健康参与者接受了ESG和DRE检查。ESG量化骶骨运动(静息外肛门括约肌张力、最大自愿肛门收缩(maxVAC)、反射(球海绵状反射或球海绵状反射(BSR))和感觉(电知觉阈值(EPT))功能,使用低强度电刺激。临床相关的DRE参数由专家小组选择。采用项目/量表内容效度指数(CVI)评估内容效度,计算与DRE (Cohen’s κ)的一致性以及对影像学证实的脊柱病变的诊断准确性。结果:在健康受试者中建立了规范的ESG值。神经功能受损患者表现为maxVAC和BSR振幅降低和EPT升高。ESG表现出良好的内容效度(S-CVI = 1.00),与DRE的VAC (κ = 0.876)和EPT (κ = 0.881)高度吻合,诊断准确率高(敏感性83.3%,特异性100%,总准确率86.5%)。结论:ESG能够在床边实时精确、可重复地评估骶骨运动、反射和感觉完整性。通过对DRE的补充和客观化,它为早期神经-骶骨评估、加强临床研究和改善脊髓损伤+诊断提供了一种有前景的精准医学工具,适用于急性期和脊髓休克。
{"title":"Development and validation of the electrosacrogram (ESG): a digital point-of-care tool for real-time neuro-sacral assessment after spinal cord injury.","authors":"Maude Duguay, Jean-Marc Mac-Thiong, Juan-David Cifuentes-Hernandez, Natan Bensoussan, Andréane Richard-Denis","doi":"10.1186/s12984-025-01797-4","DOIUrl":"10.1186/s12984-025-01797-4","url":null,"abstract":"<p><strong>Background: </strong>Accurate assessment of neuro-sacral function after spinal cord injury/lesion and cauda equina (SCI+) is essential for diagnosis, prognosis and early management. The current bedside standard, the digital rectal examination (DRE), is subjective, invasive, and examiner dependent. Surface electromyography (s-EMG) offers a quantitative alternative but has lacked point-of-care integration. We developed the ElectroSacroGram (ESG), a bedside digital s-EMG tool enabling real-time objective assessment of sacral somatic function after SCI+. This study aimed to (1) develop the ESG protocol based on clinical consensus; and (2) evaluate its diagnostic performance compared to radiological findings and expert-performed DRE.</p><p><strong>Methods: </strong>In this prospective proof-of-concept diagnostic study at a specialized Level 1 trauma center, 52 adults with suspected SCI + and 21 healthy participants underwent ESG and DRE. ESG quantified sacral motor (resting external anal sphincter tone, maximal voluntary anal contraction (maxVAC), reflex (bulbospongious or bulbocavernosus reflex (BSR)), and sensory (electrical perceptual threshold (EPT)) function using low-intensity electrical stimulation. Clinically relevant DRE parameters were selected by an expert panel. Content validity was assessed using item/scale content validity indices (CVI), agreement with DRE (Cohen's κ) and diagnostic accuracy were calculated against imaging-confirmed spinal lesions.</p><p><strong>Results: </strong>Normative ESG values were established in healthy participants. Neurologically impaired patients showed reduced maxVAC and BSR amplitudes and elevated EPT. ESG demonstrated excellent content validity (S-CVI = 1.00), strong agreement with DRE for VAC (κ = 0.876) and EPT (κ = 0.881), and high diagnostic accuracy (sensitivity 83.3%, specificity 100%, overall accuracy 86.5%).</p><p><strong>Conclusions: </strong>ESG enables precise, reproducible evaluation of sacral motor, reflex, and sensory integrity in real-time at bedside. By complementing and objectifying the DRE, it offers a promising precision-medicine tool for early neuro-sacral assessment, enhancing clinical research and improving SCI + diagnosis, for the acute phase and in the context of spinal shock.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"17"},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EMG-guided human-machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study. 肌电图引导的人机交互训练在中风中发展了新的肌间协调模式:一项试点研究。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-11 DOI: 10.1186/s12984-025-01826-2
Gang Seo, Manuel Portilla-Jiménez, Michael Houston, Jeong-Ho Park, Hangil Lee, Sheng Li, Yingchun Zhang, Hyung-Soon Park, Jinsook Roh

Background: Stroke survivors often experience impaired upper extremity motor function due to abnormal muscle synergies. This pilot study evaluated the feasibility and preliminary effectiveness of electromyography-guided human-machine interaction training designed to expand the repertoire of intermuscular coordination patterns and improve upper extremity motor function in chronic stroke survivors.

Methods: Four chronic stroke survivors with mild-to-moderate upper extremity motor impairment and three age-matched healthy controls participated in a six-week electromyography-guided training intervention. Participants practiced selectively activating one elbow flexor muscle while suppressing another (brachioradialis or biceps brachii). Throughout the course of the intervention, the effect of the training on intermuscular coordination, task performance, and motor function and impairment level of the stroke-affected upper extremity were assessed.

Results: Participants in both the control and stroke groups successfully learned to selectively activate targeted muscles, expanding their repertoire of habitual intermuscular coordination patterns. Stroke survivors demonstrated improvements in force generation, reaching ability, wrist rotation, and clinical measures of upper extremity motor function and spasticity. Participants also reported improved ease in performing daily activities.

Conclusions: This is, to our knowledge, the first study to demonstrate the feasibility of using electromyography-guided human-machine interaction training to expand the repertoire of habitual intermuscular coordination patterns and improve upper extremity motor function in chronic stroke survivors. These findings highlight the potential of electromyography-guided human-machine interaction training as a neurorehabilitation approach to address motor deficits associated with abnormal intermuscular coordination following stroke.

Trial registration: The study was registered at the Clinical Research Information Service of Korea National Institute of Health (KCT0005803).

背景:由于肌肉协同作用异常,中风幸存者经常经历上肢运动功能受损。这项初步研究评估了肌电图引导的人机交互训练的可行性和初步有效性,旨在扩大慢性中风幸存者的肌间协调模式,改善上肢运动功能。方法:四名患有轻中度上肢运动障碍的慢性中风幸存者和三名年龄匹配的健康对照者参加了为期六周的肌电图引导训练干预。参与者练习选择性地激活一侧肘关节屈肌,同时抑制另一侧(肱桡肌或肱二头肌)。在整个干预过程中,评估训练对中风上肢肌间协调、任务表现、运动功能和损伤水平的影响。结果:对照组和中风组的参与者都成功地学会了选择性地激活目标肌肉,扩大了他们习惯性肌肉间协调模式的曲目。中风幸存者在力量产生、伸手能力、手腕旋转以及上肢运动功能和痉挛的临床测量方面表现出改善。参与者还报告说,他们在日常活动中表现得更加轻松。结论:据我们所知,这是第一个证明使用肌电图引导的人机交互训练来扩展习惯性肌间协调模式和改善慢性中风幸存者上肢运动功能的可行性的研究。这些发现强调了肌电图引导的人机交互训练作为一种神经康复方法的潜力,可以解决中风后肌肉间协调异常相关的运动缺陷。试验注册:该研究已在韩国国立卫生研究院临床研究信息服务中心注册(KCT0005803)。
{"title":"EMG-guided human-machine interaction training develops new intermuscular coordination patterns in stroke: a pilot study.","authors":"Gang Seo, Manuel Portilla-Jiménez, Michael Houston, Jeong-Ho Park, Hangil Lee, Sheng Li, Yingchun Zhang, Hyung-Soon Park, Jinsook Roh","doi":"10.1186/s12984-025-01826-2","DOIUrl":"10.1186/s12984-025-01826-2","url":null,"abstract":"<p><strong>Background: </strong>Stroke survivors often experience impaired upper extremity motor function due to abnormal muscle synergies. This pilot study evaluated the feasibility and preliminary effectiveness of electromyography-guided human-machine interaction training designed to expand the repertoire of intermuscular coordination patterns and improve upper extremity motor function in chronic stroke survivors.</p><p><strong>Methods: </strong>Four chronic stroke survivors with mild-to-moderate upper extremity motor impairment and three age-matched healthy controls participated in a six-week electromyography-guided training intervention. Participants practiced selectively activating one elbow flexor muscle while suppressing another (brachioradialis or biceps brachii). Throughout the course of the intervention, the effect of the training on intermuscular coordination, task performance, and motor function and impairment level of the stroke-affected upper extremity were assessed.</p><p><strong>Results: </strong>Participants in both the control and stroke groups successfully learned to selectively activate targeted muscles, expanding their repertoire of habitual intermuscular coordination patterns. Stroke survivors demonstrated improvements in force generation, reaching ability, wrist rotation, and clinical measures of upper extremity motor function and spasticity. Participants also reported improved ease in performing daily activities.</p><p><strong>Conclusions: </strong>This is, to our knowledge, the first study to demonstrate the feasibility of using electromyography-guided human-machine interaction training to expand the repertoire of habitual intermuscular coordination patterns and improve upper extremity motor function in chronic stroke survivors. These findings highlight the potential of electromyography-guided human-machine interaction training as a neurorehabilitation approach to address motor deficits associated with abnormal intermuscular coordination following stroke.</p><p><strong>Trial registration: </strong>The study was registered at the Clinical Research Information Service of Korea National Institute of Health (KCT0005803).</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"16"},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sonomyography accurately captures joint kinematics during volitional and electrically stimulated motion in healthy adults and an individual with cerebral palsy. 超声能准确地捕捉健康成人和脑瘫患者在意志运动和电刺激运动时的关节运动学。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-11 DOI: 10.1186/s12984-025-01784-9
Shriniwas Patwardhan, Noah Rubin, Katharine E Alter, Diane L Damiano, Thomas C Bulea

Background: Despite significant advances in biosignal extraction techniques for studying neuromotor disorders, there remains an unmet need for a method that effectively links muscle structure and dynamics to muscle activation. Addressing this gap could improve the quantification of neuromuscular impairments and pave the way for precision rehabilitation. In this study, we demonstrate the proof of concept of recording multimodal signals from the brain, muscles, and resulting limb kinematics. We also explore the use of ultrasound imaging to extract limb kinematics.

Methods: We collected data from three healthy volunteers and one individual with cerebral palsy during single degree-of-freedom ankle and wrist movements. Participants performed range of motion (ROM) tasks at approximately 1-second intervals, either volitionally or through functional electrical stimulation. We simultaneously recorded electroencephalography, surface electromyography (EMG), continuous ultrasound imaging, and motion capture data. Joint kinematics were computed from ultrasound imaging using a technique called sonomyography (SMG), and we evaluated the technical feasibility of estimating joint kinematics from both sonomyography and surface EMG signals.

Results: The technical feasibility study evaluated joint angle prediction using EMG and SMG under volitional (FES-OFF) and electrically stimulated (FES-ON) conditions. Root mean squared error (RMSE) between predicted and measured joint angles was computed for multiple methods of extracting kinematics from EMG and SMG. EMG-based RMSE ranged from 0.34 to 0.57 (FES-OFF) and 0.43-0.51 (FES-ON). SMG-based RMSE ranged from 0.10 to 0.25 across all conditions and methods. Linear regression analysis produced R 2 values between 0.31 and 0.81 depending on joint, condition, and method. No significant RMSE difference was found between FES-ON and FES-OFF conditions within SMG. SMG RMSE values were also comparable to previously reported values (10-25%) in prior literature.

Conclusion: Our findings suggest that sonomyography can be used as a noninvasive method for estimating joint kinematics when the joint movement is driven either by volition or by functional electrical stimulation. This technique can potentially be be useful in evaluating altered muscle dynamics and driving assistive and rehabilitation devices in individuals with neuromotor disorders such as cerebral palsy.

背景:尽管用于研究神经运动障碍的生物信号提取技术取得了重大进展,但仍然需要一种有效地将肌肉结构和动力学与肌肉激活联系起来的方法。解决这一差距可以改善神经肌肉损伤的量化,并为精确康复铺平道路。在这项研究中,我们证明了记录来自大脑、肌肉和肢体运动学的多模态信号的概念。我们还探讨了使用超声成像提取肢体运动学。方法:我们收集了3名健康志愿者和1名脑瘫患者单自由度踝关节和手腕运动的数据。参与者以大约1秒的间隔进行活动范围(ROM)任务,可以是自愿的,也可以是通过功能性电刺激。同时记录脑电图、表面肌电图(EMG)、连续超声成像和运动捕捉数据。关节运动学是利用超声成像技术(SMG)计算的,我们评估了从超声和表面肌电信号估计关节运动学的技术可行性。结果:技术可行性研究评估了在自主(FES-OFF)和电刺激(FES-ON)条件下使用肌电图和SMG预测关节角度的可行性。对肌电图和关节图的运动学提取方法,计算了预测关节角与实测关节角的均方根误差(RMSE)。基于肌电图的RMSE范围为0.34 ~ 0.57 (FES-OFF)和0.43 ~ 0.51 (FES-ON)。在所有条件和方法中,基于smg的RMSE范围为0.10到0.25。线性回归分析产生的R2值在0.31和0.81之间,这取决于关节、条件和方法。在SMG中,FES-ON和FES-OFF条件之间没有发现显著的均方根误差差异。SMG RMSE值也与先前文献中报道的值(10-25%)相当。结论:我们的研究结果表明,当关节运动是由意志或功能性电刺激驱动时,声纳图可以作为一种无创的方法来估计关节运动学。这项技术可以潜在地用于评估肌肉动力学的改变,并在神经运动障碍(如脑瘫)患者中驱动辅助和康复设备。
{"title":"Sonomyography accurately captures joint kinematics during volitional and electrically stimulated motion in healthy adults and an individual with cerebral palsy.","authors":"Shriniwas Patwardhan, Noah Rubin, Katharine E Alter, Diane L Damiano, Thomas C Bulea","doi":"10.1186/s12984-025-01784-9","DOIUrl":"10.1186/s12984-025-01784-9","url":null,"abstract":"<p><strong>Background: </strong>Despite significant advances in biosignal extraction techniques for studying neuromotor disorders, there remains an unmet need for a method that effectively links muscle structure and dynamics to muscle activation. Addressing this gap could improve the quantification of neuromuscular impairments and pave the way for precision rehabilitation. In this study, we demonstrate the proof of concept of recording multimodal signals from the brain, muscles, and resulting limb kinematics. We also explore the use of ultrasound imaging to extract limb kinematics.</p><p><strong>Methods: </strong>We collected data from three healthy volunteers and one individual with cerebral palsy during single degree-of-freedom ankle and wrist movements. Participants performed range of motion (ROM) tasks at approximately 1-second intervals, either volitionally or through functional electrical stimulation. We simultaneously recorded electroencephalography, surface electromyography (EMG), continuous ultrasound imaging, and motion capture data. Joint kinematics were computed from ultrasound imaging using a technique called sonomyography (SMG), and we evaluated the technical feasibility of estimating joint kinematics from both sonomyography and surface EMG signals.</p><p><strong>Results: </strong>The technical feasibility study evaluated joint angle prediction using EMG and SMG under volitional (FES-OFF) and electrically stimulated (FES-ON) conditions. Root mean squared error (RMSE) between predicted and measured joint angles was computed for multiple methods of extracting kinematics from EMG and SMG. EMG-based RMSE ranged from 0.34 to 0.57 (FES-OFF) and 0.43-0.51 (FES-ON). SMG-based RMSE ranged from 0.10 to 0.25 across all conditions and methods. Linear regression analysis produced <math><msup><mi>R</mi> <mn>2</mn></msup> </math> values between 0.31 and 0.81 depending on joint, condition, and method. No significant RMSE difference was found between FES-ON and FES-OFF conditions within SMG. SMG RMSE values were also comparable to previously reported values (10-25%) in prior literature.</p><p><strong>Conclusion: </strong>Our findings suggest that sonomyography can be used as a noninvasive method for estimating joint kinematics when the joint movement is driven either by volition or by functional electrical stimulation. This technique can potentially be be useful in evaluating altered muscle dynamics and driving assistive and rehabilitation devices in individuals with neuromotor disorders such as cerebral palsy.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"15"},"PeriodicalIF":5.2,"publicationDate":"2025-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12801643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monitoring wheelchair propulsion patterns: feasibility and validity of using wearable sensors. 监测轮椅推进模式:使用可穿戴传感器的可行性和有效性。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-10 DOI: 10.1186/s12984-025-01823-5
Ramin Fathian, Aminreza Khandan, Nasim Rahmanifar, Chester Ho, Hossein Rouhani
{"title":"Monitoring wheelchair propulsion patterns: feasibility and validity of using wearable sensors.","authors":"Ramin Fathian, Aminreza Khandan, Nasim Rahmanifar, Chester Ho, Hossein Rouhani","doi":"10.1186/s12984-025-01823-5","DOIUrl":"10.1186/s12984-025-01823-5","url":null,"abstract":"","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"14"},"PeriodicalIF":5.2,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12802131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The impact of bimanual reach training with augmented position sense feedback on post-stroke upper limb somatosensory and motor impairment. 增强体位感反馈的双手伸臂训练对脑卒中后上肢躯体感觉和运动障碍的影响。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-09 DOI: 10.1186/s12984-025-01764-z
Beverley C Larssen, Ronan Denyer, Mahta Khoshnam Tehrani, Anjana Rajendran, Carlo Menon, Lara Boyd

Background: Impaired arm position sense is a common somatosensory impairment after stroke, which significantly impacts the performance of functional activities using the upper limb. However, few clinical interventions target loss of position sense after stroke. Our aim was to use interlimb force-coupling to augment position sense of the stroke-affected arm during a bilateral reaching task and investigate the impact of training with this feedback manipulation on measures of arm position matching ability and both bilateral and unilateral motor control.

Methods: Twenty-four participants with a history of stroke were randomized (N = 12/group) to perform mirrored bimanual aiming movements with either interlimb force-coupling (Augmented PF) or uncoupled symmetrical reaches with only visual feedback about movement position. Participants completed 11 sessions (295 bimanual reaches/session) using a Kinarm End-Point robot. Performance on measures of arm position sense (Arm Position Matching, APM), motor impairment (Fugl-Meyer Upper Limb, FM), motor function (Wolf Motor Function Test, WMFT), unilateral reach accuracy and speed (Visually Guided Reaching, VGR), and bilateral reach symmetry were collected before and after training to characterize changes in upper limb somatosensory and motor control performance.

Results: APM Task Scores improved for both groups. This improvement was specifically observed through reduced APM variability, but not accuracy. FM scores also improved for both groups. The group that did not practice with force-coupling between limbs improved on measures of bilateral movement symmetry on a mirrored reaching task and had faster VGR movement times in post-test.

Conclusion: Symmetrical reach training with or without augmented PF led to reduced motor impairment and benefited upper limb position matching ability by reducing APM variability. Augmenting position sense during reaching did not provide additional benefits for position matching accuracy. Advantages for unilateral movement speed and bilateral reach symmetry measures in the group that practiced without interlimb coupling may reflect specificity of practice effects due to similarity between test and training conditions for this group.

背景:手臂位置感受损是卒中后常见的躯体感觉障碍,严重影响上肢功能活动的表现。然而,针对脑卒中后位置感丧失的临床干预措施很少。我们的目的是使用肢间力耦合来增强受中风影响的手臂在双侧伸展任务中的位置感,并研究这种反馈操作训练对手臂位置匹配能力和双侧和单侧运动控制的影响。方法:24例卒中患者随机(N = 12/组),采用肢间力耦合(增强PF)或不耦合对称动作,仅视觉反馈运动位置,进行镜像双手瞄准运动。参与者使用Kinarm End-Point机器人完成了11个会话(295个手动到达/会话)。在训练前后收集上肢体位感(APM)、运动障碍(Fugl-Meyer上肢,FM)、运动功能(Wolf运动功能测试,WMFT)、单侧伸臂精度和速度(视觉引导伸臂,VGR)和双侧伸臂对称性的测试结果,以表征上肢体感和运动控制性能的变化。结果:两组的APM任务得分均有提高。这种改进是通过降低APM可变性而不是准确性观察到的。两组的FM得分也都有所提高。没有进行肢体间力耦合练习的那组在镜像到达任务的双侧运动对称性测量上有所改善,并且在测试后的VGR运动时间更快。结论:对称前伸训练可减少运动障碍,并通过减少APM变异性提高上肢位置匹配能力。在到达过程中增加位置感对位置匹配精度没有额外的好处。在无肢间耦合训练组中,单侧运动速度和双侧到达对称测量的优势可能反映了由于该组测试和训练条件的相似性,练习效果的特异性。
{"title":"The impact of bimanual reach training with augmented position sense feedback on post-stroke upper limb somatosensory and motor impairment.","authors":"Beverley C Larssen, Ronan Denyer, Mahta Khoshnam Tehrani, Anjana Rajendran, Carlo Menon, Lara Boyd","doi":"10.1186/s12984-025-01764-z","DOIUrl":"10.1186/s12984-025-01764-z","url":null,"abstract":"<p><strong>Background: </strong>Impaired arm position sense is a common somatosensory impairment after stroke, which significantly impacts the performance of functional activities using the upper limb. However, few clinical interventions target loss of position sense after stroke. Our aim was to use interlimb force-coupling to augment position sense of the stroke-affected arm during a bilateral reaching task and investigate the impact of training with this feedback manipulation on measures of arm position matching ability and both bilateral and unilateral motor control.</p><p><strong>Methods: </strong>Twenty-four participants with a history of stroke were randomized (N = 12/group) to perform mirrored bimanual aiming movements with either interlimb force-coupling (Augmented PF) or uncoupled symmetrical reaches with only visual feedback about movement position. Participants completed 11 sessions (295 bimanual reaches/session) using a Kinarm End-Point robot. Performance on measures of arm position sense (Arm Position Matching, APM), motor impairment (Fugl-Meyer Upper Limb, FM), motor function (Wolf Motor Function Test, WMFT), unilateral reach accuracy and speed (Visually Guided Reaching, VGR), and bilateral reach symmetry were collected before and after training to characterize changes in upper limb somatosensory and motor control performance.</p><p><strong>Results: </strong>APM Task Scores improved for both groups. This improvement was specifically observed through reduced APM variability, but not accuracy. FM scores also improved for both groups. The group that did not practice with force-coupling between limbs improved on measures of bilateral movement symmetry on a mirrored reaching task and had faster VGR movement times in post-test.</p><p><strong>Conclusion: </strong>Symmetrical reach training with or without augmented PF led to reduced motor impairment and benefited upper limb position matching ability by reducing APM variability. Augmenting position sense during reaching did not provide additional benefits for position matching accuracy. Advantages for unilateral movement speed and bilateral reach symmetry measures in the group that practiced without interlimb coupling may reflect specificity of practice effects due to similarity between test and training conditions for this group.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":"22 1","pages":"260"},"PeriodicalIF":5.2,"publicationDate":"2025-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12690791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Berlin bimanual test for stroke survivors (BeBiT-S): evaluating exoskeleton-assisted bimanual motor function after stroke. 脑卒中幸存者的柏林双手测试(BeBiT-S):评估脑卒中后外骨骼辅助的双手运动功能。
IF 5.2 2区 医学 Q1 ENGINEERING, BIOMEDICAL Pub Date : 2025-12-08 DOI: 10.1186/s12984-025-01822-6
Mareike Vermehren, Annalisa Colucci, Cornelius Angerhöfer, Niels Peekhaus, Won-Seok Kim, Won Kee Chang, Hyunji Kim, Volker Hömberg, Nam-Jong Paik, Surjo R Soekadar

Background: Brain/neural hand exoskeletons (B/NHEs) can restore motor function after severe stroke, enabling bimanual tasks critical for various activities of daily living. Yet, reliable clinical tests for assessing bimanual function compatible with B/NHEs are lacking. Here, we introduce the Berlin Bimanual Test for Stroke (BeBiT-S), a 10-task assessment focused on everyday bimanual activities, and evaluate its psychometric properties as well as compatibility with assistive technologies such as B/NHEs.

Methods: BeBiT-S tasks were selected based on their relevance to daily activities, representation of various grasp types, and compatibility with current (neuro-)prosthetic devices. A scoring system was developed to assess key aspects of bimanual function-including reaching, grasping, stabilizing, manipulating, and lifting-based on video recordings of task performance. The BeBiT-S was administered without support of assistive technology (unassisted condition) to 24 stroke survivors (mean age = 56.5 years; 9 female) with upper-limb hemiparesis. We evaluated interrater reliability through the intraclass correlation coefficient (ICC) and construct validity through correlations with the Chedoke Arm and Hand Activity Inventory (CAHAI), and Stroke Impact Scale (SIS). A subgroup of 15 stroke survivors (mean age 50.3 years, 5 female) completed a second session supported by a B/NHE (B/NHE-assisted condition) to assess the BeBiT-S' sensitivity to change related to B/NHE-application.

Results: The BeBiT-S demonstrated high interrater reliability in both the unassisted (ICC = 0.985, P < .001) and B/NHE-assisted (ICC = 0.862, P < .001) conditions. Unassisted BeBiT-S scores correlated with the CAHAI-8 (r(22) = 0.95, P < .001) and the SIS subscales "strength" (r(20) = 0.53, P = .012) and "hand function" (r(20) = 0.50, P = .018), indicating construct validity. BeBiT-S scores improved significantly with B/NHE assistance (Mdn = 60, P < .05), compared to when no assistance was provided (Mdn = 38, P < .05), demonstrating the test's sensitivity to change following the application of a B/NHE.

Conclusions: The findings support that the BeBiT-S is a reliable and valid tool for evaluating bimanual task performance in stroke survivors and is compatible with the use of assistive technology such as B/NHEs. Trial registration NCT04440709, submitted June 18th, 2020.

背景:脑/神经手外骨骼(B/NHEs)可以恢复严重中风后的运动功能,使日常生活中各种重要活动的双手任务成为可能。然而,评估与B/NHEs兼容的双手功能的可靠临床试验是缺乏的。在这里,我们介绍了柏林双手脑卒中测试(BeBiT-S),这是一个专注于日常双手活动的10个任务评估,并评估其心理测量特性以及与辅助技术(如B/NHEs)的兼容性。方法:根据BeBiT-S任务与日常活动的相关性、各种抓取类型的表征以及与当前(神经)假肢装置的兼容性来选择BeBiT-S任务。基于任务表现的视频记录,开发了一个评分系统来评估双手功能的关键方面,包括伸手、抓握、稳定、操纵和举起。对24例上肢偏瘫中风幸存者(平均年龄56.5岁,9例女性)进行BeBiT-S治疗,无辅助技术支持(无辅助条件)。我们通过类内相关系数(ICC)来评估量表的信度,并通过与Chedoke手臂和手活动量表(CAHAI)和中风影响量表(SIS)的相关性来构建效度。15名脑卒中幸存者(平均年龄50.3岁,5名女性)在B/NHE (B/NHE辅助条件)的支持下完成第二次治疗,以评估BeBiT-S对B/NHE应用相关变化的敏感性。结果:BeBiT-S在无辅助的两种情况下均表现出较高的互信度(ICC = 0.985, P)。结论:研究结果支持BeBiT-S是一种可靠有效的评估脑卒中幸存者双手任务表现的工具,并且与B/NHEs等辅助技术的使用兼容。试验注册编号NCT04440709,提交日期为2020年6月18日。
{"title":"The Berlin bimanual test for stroke survivors (BeBiT-S): evaluating exoskeleton-assisted bimanual motor function after stroke.","authors":"Mareike Vermehren, Annalisa Colucci, Cornelius Angerhöfer, Niels Peekhaus, Won-Seok Kim, Won Kee Chang, Hyunji Kim, Volker Hömberg, Nam-Jong Paik, Surjo R Soekadar","doi":"10.1186/s12984-025-01822-6","DOIUrl":"10.1186/s12984-025-01822-6","url":null,"abstract":"<p><strong>Background: </strong>Brain/neural hand exoskeletons (B/NHEs) can restore motor function after severe stroke, enabling bimanual tasks critical for various activities of daily living. Yet, reliable clinical tests for assessing bimanual function compatible with B/NHEs are lacking. Here, we introduce the Berlin Bimanual Test for Stroke (BeBiT-S), a 10-task assessment focused on everyday bimanual activities, and evaluate its psychometric properties as well as compatibility with assistive technologies such as B/NHEs.</p><p><strong>Methods: </strong>BeBiT-S tasks were selected based on their relevance to daily activities, representation of various grasp types, and compatibility with current (neuro-)prosthetic devices. A scoring system was developed to assess key aspects of bimanual function-including reaching, grasping, stabilizing, manipulating, and lifting-based on video recordings of task performance. The BeBiT-S was administered without support of assistive technology (unassisted condition) to 24 stroke survivors (mean age = 56.5 years; 9 female) with upper-limb hemiparesis. We evaluated interrater reliability through the intraclass correlation coefficient (ICC) and construct validity through correlations with the Chedoke Arm and Hand Activity Inventory (CAHAI), and Stroke Impact Scale (SIS). A subgroup of 15 stroke survivors (mean age 50.3 years, 5 female) completed a second session supported by a B/NHE (B/NHE-assisted condition) to assess the BeBiT-S' sensitivity to change related to B/NHE-application.</p><p><strong>Results: </strong>The BeBiT-S demonstrated high interrater reliability in both the unassisted (ICC = 0.985, P < .001) and B/NHE-assisted (ICC = 0.862, P < .001) conditions. Unassisted BeBiT-S scores correlated with the CAHAI-8 (r(22) = 0.95, P < .001) and the SIS subscales \"strength\" (r(20) = 0.53, P = .012) and \"hand function\" (r(20) = 0.50, P = .018), indicating construct validity. BeBiT-S scores improved significantly with B/NHE assistance (Mdn = 60, P < .05), compared to when no assistance was provided (Mdn = 38, P < .05), demonstrating the test's sensitivity to change following the application of a B/NHE.</p><p><strong>Conclusions: </strong>The findings support that the BeBiT-S is a reliable and valid tool for evaluating bimanual task performance in stroke survivors and is compatible with the use of assistive technology such as B/NHEs. Trial registration NCT04440709, submitted June 18th, 2020.</p>","PeriodicalId":16384,"journal":{"name":"Journal of NeuroEngineering and Rehabilitation","volume":" ","pages":"261"},"PeriodicalIF":5.2,"publicationDate":"2025-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12699850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of NeuroEngineering and Rehabilitation
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1