P. Shrivastav, Suyog Yawale, Suraj Tichkule, S. Parwe
The present case report was a 25-year-old male patient with severe pain at the right index finger, fever, oedema, and discharge, not having any history of surgery, hypertension, diabetes, or any systemic disorder was diagnosed with kotha roga (necrotizing fasciitis). Presently available treatment for this is broad-spectrum intravenous antibiotics, appropriate hydration support, and meticulous surgical debridement with regular wound packing. But because of contaminated wounds and poor prognosis, herbal therapies have a possibility to cure kotha as they are readily available, and inexpensive. In this case, a kshara formulation i.e., modified ksharpichu was chosen as an atrial medication to be applied locally after everyday cleaning and dressing. It was observed that ksharpichu acted as a debriding agent and healing as well. The case was followed up for 30 days. This study employed pretty simple criteria to gain preliminary observations on the effectiveness of this Kshara taila on kotha roga.
{"title":"Management of Kotha Roga (Necrotizing Fasciitis) by Modified Ksharapichu (Wound Packing): A Case Report","authors":"P. Shrivastav, Suyog Yawale, Suraj Tichkule, S. Parwe","doi":"10.18311/jnr/2024/34920","DOIUrl":"https://doi.org/10.18311/jnr/2024/34920","url":null,"abstract":"The present case report was a 25-year-old male patient with severe pain at the right index finger, fever, oedema, and discharge, not having any history of surgery, hypertension, diabetes, or any systemic disorder was diagnosed with kotha roga (necrotizing fasciitis). Presently available treatment for this is broad-spectrum intravenous antibiotics, appropriate hydration support, and meticulous surgical debridement with regular wound packing. But because of contaminated wounds and poor prognosis, herbal therapies have a possibility to cure kotha as they are readily available, and inexpensive. In this case, a kshara formulation i.e., modified ksharpichu was chosen as an atrial medication to be applied locally after everyday cleaning and dressing. It was observed that ksharpichu acted as a debriding agent and healing as well. The case was followed up for 30 days. This study employed pretty simple criteria to gain preliminary observations on the effectiveness of this Kshara taila on kotha roga.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"14 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Primary focal hyperhidrosis (primary hyperhidrosis) is a pathological disorder characterised by excessive sweating in the local sites such as the palmar surface of the hands, axillae, soles and face to a degree that interferes with daily life in affected persons. This case report brings into light an innovative management of Primary Hyperhidrosis. Ayurvedic formulations such as Patolakaturohinyadi Kashayam for internal use and Shireeshadi Choornam as Avachoornana for external use were administered for this condition. After 35 days, the patient was re-examined and there was a significant change in Transepidermal Water Loss (TEWL hydration values and Hyperhidrosis Disease Severity Scale (HDSS) and Hyperhidrosis Quality of Life (HidroQOL) scores.
{"title":"Management of Primary Hyperhidrosis With Patolakaturohinyadi Kashayam and Shireeshadi Choornam (Avachoornana) – A Case Report","authors":"G. Deepthikrishna, Devipriya Soman","doi":"10.18311/jnr/2024/34776","DOIUrl":"https://doi.org/10.18311/jnr/2024/34776","url":null,"abstract":"ABSTRACT\u0000 Primary focal hyperhidrosis (primary hyperhidrosis) is a pathological disorder characterised by excessive sweating in the local sites such as the palmar surface of the hands, axillae, soles and face to a degree that interferes with daily life in affected persons. This case report brings into light an innovative management of Primary Hyperhidrosis. Ayurvedic formulations such as Patolakaturohinyadi Kashayam for internal use and Shireeshadi Choornam as Avachoornana for external use were administered for this condition. After 35 days, the patient was re-examined and there was a significant change in Transepidermal Water Loss (TEWL hydration values and Hyperhidrosis Disease Severity Scale (HDSS) and Hyperhidrosis Quality of Life (HidroQOL) scores.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. S. Kuchkarova, Khasan Yusuf Ogli Kayumov, N. Ergashev, Gulchekhra Telgenbaevna Kudeshovа
Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate. Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3rd experimental group, rats were nursed by intact mothers. In the 1st and 2nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3rd to 20th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7th, 14th, and 21st days after birth. Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity. Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.
{"title":"Effect of Quercetin on the Intestinal Carbohydrases Activity in the Offspring of the Lead Intoxicated Mother","authors":"L. S. Kuchkarova, Khasan Yusuf Ogli Kayumov, N. Ergashev, Gulchekhra Telgenbaevna Kudeshovа","doi":"10.18311/jnr/2024/32682","DOIUrl":"https://doi.org/10.18311/jnr/2024/32682","url":null,"abstract":"Aim: This work aims to investigate the effect of quercetin on the development of small intestine disaccharidase activity in the offspring intoxicated with lead acetate.\u0000Material and Methods: The experiments were carried out on white outbred rats. Rats were divided into control and three experimental groups. In the control and 3rd experimental group, rats were nursed by intact mothers. In the 1st and 2nd experimental groups, rats were nursed by mothers who replaced drinking water with a 0.2% lead acetate solution. All experimental groups of rats were orally treated with quercetin (20 mg/kg/24 h) from the 3rd to 20th days of postnatal life. Body weight, small intestine weight as well as the activities of intestinal maltase and lactase were determined on the 7th, 14th, and 21st days after birth.\u0000Results: In rats nursed by mothers who used a solution of lead acetate instead of drinking water а body weight and the small intestine mucosa weight decreased, but intestinal maltase and lactase activity increased. Treatment of lead-intoxicated growing rats with quercetin restored the body weight, small intestine mucosa weight, and development rate of maltase and lactase activity.\u0000Conclusion: The effect of quercetin on the activity of intestinal maltase and sucrase in growing rats nursed by lead acetate consumed mother is mediated through the restoration of intoxication damage since treatment of intact growing rats with quercetin in the same way and at the same time did not affect on the intestinal disaccharidases activity.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"15 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139822348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since ancient times, medicinal plants have been the primary source of most medications. In actuality, a large number of the medications that are now on the market may be obtained either directly in extract form or in modified synthetic form. As phytoconstituents, which are employed by plants to carry out biological processes and defend us from predators like viruses, fungi, and other microbes, they are naturally able to produce goods that are helpful for humans. Hernandia nymphaeifolia is a traditional medicinal plant that is used in several traditional remedies to treat several ailments. The extracts from various portions of the plant have excellent therapeutic effectiveness. Numerous pharmacological investigations have demonstrated this plant’s capacity to display anti-cytotoxic, anti-inflammatory, anti-platelet aggregation, vasodilator, antioxidant, anti-microbial, and Ca2+ signalling properties. The current study covers a thorough examination of the plant’s systematic botanical position, phytochemical analysis, investigations into the plant’s pharmacological activity, and therapeutic uses.
{"title":"A Review of the Phytochemical and Pharmacological Characteristics of Hernandia nymphaeifolia","authors":"Sumana Das, Afsana Khan, Amlan Bishal, Bratati Badyopadhya, Mohini Mondal, Aveek Datta, Shilpy Jha, Raneet Das, Biplab Debnath","doi":"10.18311/jnr/2024/34770","DOIUrl":"https://doi.org/10.18311/jnr/2024/34770","url":null,"abstract":"Since ancient times, medicinal plants have been the primary source of most medications. In actuality, a large number of the medications that are now on the market may be obtained either directly in extract form or in modified synthetic form. As phytoconstituents, which are employed by plants to carry out biological processes and defend us from predators like viruses, fungi, and other microbes, they are naturally able to produce goods that are helpful for humans. Hernandia nymphaeifolia is a traditional medicinal plant that is used in several traditional remedies to treat several ailments. The extracts from various portions of the plant have excellent therapeutic effectiveness. Numerous pharmacological investigations have demonstrated this plant’s capacity to display anti-cytotoxic, anti-inflammatory, anti-platelet aggregation, vasodilator, antioxidant, anti-microbial, and Ca2+ signalling properties. The current study covers a thorough examination of the plant’s systematic botanical position, phytochemical analysis, investigations into the plant’s pharmacological activity, and therapeutic uses.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"13 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139822584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kombucha is a traditional carbonated tea obtained by fermentation with Symbiotic Culture of Bacteria and Yeast(SCOBY). The SCOBY consumes sugar in tea and produces enzymes and organic acids. The process typically takes one or two weeks and changes tea into a fizzy, slightly sour fermented (generally non-alcoholic) beverage. Kombucha contains chemical and biologically active compounds such as polyphenols, antioxidants, and a source of probiotics (Lactobacillus) that show health-promoting properties. Kombucha has potential health benefits, but not all have been proven in studies with humans. It is being commercialized in India and can be prepared at home easily with precautions. It can be prepared by fermenting sweetened green or black tea using a Symbiotic Culture of Bacteria and Yeast (SCOBY). As the fermentation proceeds, the yeast in the SCOBY breaks down the sugar present in the tea and releases friendly probiotic bacteria. In this paper, we highlighted various factors affecting fermentation, where the pH shows a significant impact on the tea quality. Herein, we have also discussed the health benefits and toxicity of Kombucha tea along with the recent literature.
{"title":"Natural Carbonated Drink (Kombucha Tea) and its Health Benefits: A Review","authors":"Kalpana Gupta, Yogita Malhotra, Priyanka Choudhary","doi":"10.18311/jnr/2024/34587","DOIUrl":"https://doi.org/10.18311/jnr/2024/34587","url":null,"abstract":"Kombucha is a traditional carbonated tea obtained by fermentation with Symbiotic Culture of Bacteria and Yeast(SCOBY). The SCOBY consumes sugar in tea and produces enzymes and organic acids. The process typically takes one or two weeks and changes tea into a fizzy, slightly sour fermented (generally non-alcoholic) beverage. Kombucha contains chemical and biologically active compounds such as polyphenols, antioxidants, and a source of probiotics (Lactobacillus) that show health-promoting properties. Kombucha has potential health benefits, but not all have been proven in studies with humans. It is being commercialized in India and can be prepared at home easily with precautions. It can be prepared by fermenting sweetened green or black tea using a Symbiotic Culture of Bacteria and Yeast (SCOBY). As the fermentation proceeds, the yeast in the SCOBY breaks down the sugar present in the tea and releases friendly probiotic bacteria. In this paper, we highlighted various factors affecting fermentation, where the pH shows a significant impact on the tea quality. Herein, we have also discussed the health benefits and toxicity of Kombucha tea along with the recent literature.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"58 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Primary focal hyperhidrosis (primary hyperhidrosis) is a pathological disorder characterised by excessive sweating in the local sites such as the palmar surface of the hands, axillae, soles and face to a degree that interferes with daily life in affected persons. This case report brings into light an innovative management of Primary Hyperhidrosis. Ayurvedic formulations such as Patolakaturohinyadi Kashayam for internal use and Shireeshadi Choornam as Avachoornana for external use were administered for this condition. After 35 days, the patient was re-examined and there was a significant change in Transepidermal Water Loss (TEWL hydration values and Hyperhidrosis Disease Severity Scale (HDSS) and Hyperhidrosis Quality of Life (HidroQOL) scores.
{"title":"Management of Primary Hyperhidrosis With Patolakaturohinyadi Kashayam and Shireeshadi Choornam (Avachoornana) – A Case Report","authors":"G. Deepthikrishna, Devipriya Soman","doi":"10.18311/jnr/2024/34776","DOIUrl":"https://doi.org/10.18311/jnr/2024/34776","url":null,"abstract":"ABSTRACT\u0000 Primary focal hyperhidrosis (primary hyperhidrosis) is a pathological disorder characterised by excessive sweating in the local sites such as the palmar surface of the hands, axillae, soles and face to a degree that interferes with daily life in affected persons. This case report brings into light an innovative management of Primary Hyperhidrosis. Ayurvedic formulations such as Patolakaturohinyadi Kashayam for internal use and Shireeshadi Choornam as Avachoornana for external use were administered for this condition. After 35 days, the patient was re-examined and there was a significant change in Transepidermal Water Loss (TEWL hydration values and Hyperhidrosis Disease Severity Scale (HDSS) and Hyperhidrosis Quality of Life (HidroQOL) scores.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"48 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Surya Prabha Matangi, R. Samineni, Kanhaiya Kumar, Ashutosh Kumar, Shantanu Kumar, M. Salmon Raju
Different plant components have been used in medicinal preparations in indigenous systems of medicine to clean teeth or treat oral diseases such as periodontal disease. Herbal toothpaste is equally as good at controlling plaque and gingivitis as dentifrices made according to standard formulas. Streptococcus mutants, out of all the examined bacteria, were shown towards the most susceptible to the created dentifrice, as evidenced by a zone inhibition (7-8 mm), followed by Escherichia coli (7 mm), as well as oral micro-biota (8mm). The created Poly-herbal dentifrice was successfully tested using a variety of industry-recognized standards to verify its high quality and physio-chemical qualities. According to the findings, the created Poly-herbal dentifrice shows promise for having antibacterial properties on both gramme-positive and gramme-negative organisms. Compared to completely synthetic dentifrice, it must be safer. For the development of Poly-herbal dentifrice to be proven safe and effective, more research is required. According to the study’s findings, herbal toothpaste is safer and has fewer side effects than synthetic preparations. It is also more commonly used in dentistry research. The toothpaste that is designed for oral hygiene and teeth shows antimicrobial activity against pathogens. The market preparation was contrasted with the formulation. Therefore, it demonstrates an equal amount of patronizing and engrossing passion for the promoted formulations. The development of herbal toothpaste has a promising future in the research of natural cures and general dental health.
{"title":"Plants as Regular Phytochemical Sources of Dentistry - Formulation and Evaluation of Polyherbal Tooth Paste","authors":"Surya Prabha Matangi, R. Samineni, Kanhaiya Kumar, Ashutosh Kumar, Shantanu Kumar, M. Salmon Raju","doi":"10.18311/jnr/2024/34575","DOIUrl":"https://doi.org/10.18311/jnr/2024/34575","url":null,"abstract":"Different plant components have been used in medicinal preparations in indigenous systems of medicine to clean teeth or treat oral diseases such as periodontal disease. Herbal toothpaste is equally as good at controlling plaque and gingivitis as dentifrices made according to standard formulas. Streptococcus mutants, out of all the examined bacteria, were shown towards the most susceptible to the created dentifrice, as evidenced by a zone inhibition (7-8 mm), followed by Escherichia coli (7 mm), as well as oral micro-biota (8mm). The created Poly-herbal dentifrice was successfully tested using a variety of industry-recognized standards to verify its high quality and physio-chemical qualities. According to the findings, the created Poly-herbal dentifrice shows promise for having antibacterial properties on both gramme-positive and gramme-negative organisms. Compared to completely synthetic dentifrice, it must be safer. For the development of Poly-herbal dentifrice to be proven safe and effective, more research is required. According to the study’s findings, herbal toothpaste is safer and has fewer side effects than synthetic preparations. It is also more commonly used in dentistry research. The toothpaste that is designed for oral hygiene and teeth shows antimicrobial activity against pathogens. The market preparation was contrasted with the formulation. Therefore, it demonstrates an equal amount of patronizing and engrossing passion for the promoted formulations. The development of herbal toothpaste has a promising future in the research of natural cures and general dental health.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"35 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sagar F. Magar, Mamata Nakade, Rahul Kshirsagar, Snehalata Pawar
Oligospermia is one of the most common reasons for infertility in day-to-day life. Infertility is a widespread issue that affects 8-12 % of couples globally on average and is getting worse day by day. It was observed that the pathology is found in approximately incidence of 60% males alone in infertile couples. In Ayurveda, Oligospermia can be correlated with Shukra-Alpta. Bastikarma is considered to be having particular action on Shukra Dhatu and Chatuprasrutik Basti is explained as Shukrakrut Basti in Charak Samhita, So in this study, Chatuprasrutik Basti was selected in the management of Oligospermia. Aim: This clinical investigation looked into how Chatuprasrutik Basti affected the number of sperm in patients with infertility. Study Design: This was interventional clinical research with one arm. Materials and Methods: Chatuprasrutik Basti was administered for two cycles of Basti of 6 days each with a month gap in Seven newly diagnosed cases of Oligospermia from the outpatient Department of Panchakarma at SST’s Ayurved Mahavidyalaya in, Sangamner, Ahmednagar, Maharashtra, India. Statistical Analysis: The “Student paired t-test” was used statistically to analyze the data. Results: At the conclusion of therapy, a significant (p<0.05) result was found in the evaluation of an objective parameter, specifically sperm count, and a significant result was not found in the evaluation of the factor sperm motility as p>0.05. Conclusion: Chatuprasrutik Basti is effective in the management of Oligospermia considering the factor of sperm count.
{"title":"Efficacy of Chatuprasrutik Basti in Management Of Oligospermia – A Pilot Study","authors":"Sagar F. Magar, Mamata Nakade, Rahul Kshirsagar, Snehalata Pawar","doi":"10.18311/jnr/2024/35339","DOIUrl":"https://doi.org/10.18311/jnr/2024/35339","url":null,"abstract":"Oligospermia is one of the most common reasons for infertility in day-to-day life. Infertility is a widespread issue that affects 8-12 % of couples globally on average and is getting worse day by day. It was observed that the pathology is found in approximately incidence of 60% males alone in infertile couples. In Ayurveda, Oligospermia can be correlated with Shukra-Alpta. Bastikarma is considered to be having particular action on Shukra Dhatu and Chatuprasrutik Basti is explained as Shukrakrut Basti in Charak Samhita, So in this study, Chatuprasrutik Basti was selected in the management of Oligospermia.\u0000Aim: This clinical investigation looked into how Chatuprasrutik Basti affected the number of sperm in patients with infertility.\u0000Study Design: This was interventional clinical research with one arm.\u0000Materials and Methods: Chatuprasrutik Basti was administered for two cycles of Basti of 6 days each with a month gap in Seven newly diagnosed cases of Oligospermia from the outpatient Department of Panchakarma at SST’s Ayurved Mahavidyalaya in, Sangamner, Ahmednagar, Maharashtra, India.\u0000Statistical Analysis: The “Student paired t-test” was used statistically to analyze the data.\u0000Results: At the conclusion of therapy, a significant (p<0.05) result was found in the evaluation of an objective parameter, specifically sperm count, and a significant result was not found in the evaluation of the factor sperm motility as p>0.05.\u0000Conclusion: Chatuprasrutik Basti is effective in the management of Oligospermia considering the factor of sperm count.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"102 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139832966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, Sourav Guha
Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.
{"title":"Evaluating the Effect of Moringa concanensis on Aluminium Chloride-Induced Anemia in Wistar Rats","authors":"Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, Sourav Guha","doi":"10.18311/jnr/2024/34553","DOIUrl":"https://doi.org/10.18311/jnr/2024/34553","url":null,"abstract":"Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"29 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stroke is one of the leading causes of adult neurological disability across the globe. Currently, Intracranial Haemorrhage (ICH) has the highest mortality rate of all stroke subtypes. An ICH accounts for only 15% of all stroke subtypes but is one of the most disabling forms of stroke. Over one-third of patients with ICH do not survive and only 20% regain functional independence. This high rate of morbidity and mortality has prompted investigations into new medical and alternative medical therapies for ICH. The stroke is defined in the context of pakshaghata as a vatavyadhi affecting the madhyama rogamarga in which the siras and snayus are affected. The patient was administered to Rookshana followed by oleation, fomentation, purification, enema, and nasal purgation along with selected samana drugs. Assessments were done before and after treatment using Medical Research Council (MRC) Scales, Modified Rankin Scale (mRS), and National Institutes of Health Stroke Scales (NIHSS). The assessments revealed a positive approach to external and internal Ayurvedic treatments as a supporting treatment for the management of stroke due to ICH. The gradual recovery was promising and worth documenting.
中风是导致全球成人神经残疾的主要原因之一。目前，在所有中风亚型中，颅内出血（ICH）的死亡率最高。ICH 仅占所有中风亚型的 15%，但却是致残率最高的中风形式之一。超过三分之一的 ICH 患者无法存活，只有 20% 的患者能恢复功能独立。如此高的发病率和死亡率促使人们研究治疗 ICH 的新医疗方法和替代疗法。中风在 pakshaghata 中被定义为影响 madhyama rogamarga 的 vatavyadhi，其中 siras 和 snayus 受到影响。在对患者进行 Rookshana 治疗后，还使用了发油、熏蒸、净化、灌肠和鼻腔净化等方法，并使用了选定的 Samana 药物。治疗前后使用医学研究委员会（MRC）量表、改良朗肯量表（mRS）和美国国立卫生研究院卒中量表（NIHSS）进行了评估。评估结果显示，患者积极采用内外阿育吠陀疗法作为治疗 ICH 引起的中风的辅助疗法。患者逐渐恢复的情况令人鼓舞，值得记录在案。
{"title":"Ayurveda as a Supportive Treatment: A Case Report on Integrative Management of Intracranial Haemorrhage","authors":"Preethy Bhasimon, Aswathy Mohan, Radhika Sourabh","doi":"10.18311/jnr/2024/33818","DOIUrl":"https://doi.org/10.18311/jnr/2024/33818","url":null,"abstract":"Stroke is one of the leading causes of adult neurological disability across the globe. Currently, Intracranial Haemorrhage (ICH) has the highest mortality rate of all stroke subtypes. An ICH accounts for only 15% of all stroke subtypes but is one of the most disabling forms of stroke. Over one-third of patients with ICH do not survive and only 20% regain functional independence. This high rate of morbidity and mortality has prompted investigations into new medical and alternative medical therapies for ICH. The stroke is defined in the context of pakshaghata as a vatavyadhi affecting the madhyama rogamarga in which the siras and snayus are affected. The patient was administered to Rookshana followed by oleation, fomentation, purification, enema, and nasal purgation along with selected samana drugs. Assessments were done before and after treatment using Medical Research Council (MRC) Scales, Modified Rankin Scale (mRS), and National Institutes of Health Stroke Scales (NIHSS). The assessments revealed a positive approach to external and internal Ayurvedic treatments as a supporting treatment for the management of stroke due to ICH. The gradual recovery was promising and worth documenting.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"74 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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