Kinjal P. Patel, Rahul Trivedi, Rajesh A. Maheshwari
The utilization of herbs, spices, and other plant components has a rich historical background in Indian medicine. In ancient and medieval economies, spices were among the most demanded resources. Although herbalists and alternative medicine practitioners have relied on plants for health and healing for decades, it is only in the last few decades that scientists have begun to investigate the medicinal properties of ordinary herbs and spices. Spices’ anti-hypertensive, anti-hypercholesterolemia, anti-diabetic, and anti-inflammatory characteristics are of utmost relevance in the modern world because of the prevalence of illnesses like diabetes, cardiovascular disease, arthritis, and cancer. Throughout the Middle Ages, people employed herbs and spices for cooking, food preservation, and even medicine. In developing nations like India, where poverty and malnutrition are widespread, a better understanding of plant-derived compounds and spices’ antioxidants and therapeutic effects could lower healthcare expenses. It has been postulated that food significantly impacts the onset of various human diseases, including cardiovascular disease. This manuscript looks at the research on how certain spices, such as garlic, ginger, cardamom, and cinnamon, can affect health problems like hypertension.
{"title":"An Overview of the Benefits of Indian Spices for High Blood Pressure","authors":"Kinjal P. Patel, Rahul Trivedi, Rajesh A. Maheshwari","doi":"10.18311/jnr/2023/33475","DOIUrl":"https://doi.org/10.18311/jnr/2023/33475","url":null,"abstract":"The utilization of herbs, spices, and other plant components has a rich historical background in Indian medicine. In ancient and medieval economies, spices were among the most demanded resources. Although herbalists and alternative medicine practitioners have relied on plants for health and healing for decades, it is only in the last few decades that scientists have begun to investigate the medicinal properties of ordinary herbs and spices. Spices’ anti-hypertensive, anti-hypercholesterolemia, anti-diabetic, and anti-inflammatory characteristics are of utmost relevance in the modern world because of the prevalence of illnesses like diabetes, cardiovascular disease, arthritis, and cancer. Throughout the Middle Ages, people employed herbs and spices for cooking, food preservation, and even medicine. In developing nations like India, where poverty and malnutrition are widespread, a better understanding of plant-derived compounds and spices’ antioxidants and therapeutic effects could lower healthcare expenses. It has been postulated that food significantly impacts the onset of various human diseases, including cardiovascular disease. This manuscript looks at the research on how certain spices, such as garlic, ginger, cardamom, and cinnamon, can affect health problems like hypertension.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"2 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136018324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aishwarya Ashish Joglekar, Mahesh Vyas, Meera K. Bhojani, Anil Kumar
Introduction: Ayurveda beautifully amalgamates herbal drugs and lifestyle modifications in the management of various diseases and lifestyle disorders. Diabesity is one condition representing the two most prevalent chronic non-communicable diseases, i.e., Diabetes and Obesity According to Ayurveda, both conditions are referred to as Prameha and Sthoulya, respectively. Both the conditions are Santarpanottha Vyadhi (diseases arising from excessive and improper nutrition), having the common vitiation of Kapha Dosha, Meda Dhatu and Ama and similar lines of treatment. Haritaki or Abhaya (Terminalia chebula) is a herb that has the potential to manage both diabetes and obesity. The present study focuses on the efficacy of Abhaya Ghana Vati as a single drug regime coupled with Pathya Aahara Vihara (diet and lifestyle regime) in the management of diabesity. Methods: Abhaya Ghana Vati along with Pathya Aahara Vihara (diet and lifestyle regime), was administered in 41 patients for three months, including follow-up. The patients were assessed for the effect of the intervention on the subjective and objective criteria. Results: The intervention showed significant improvement in most of the parameters of outcome measures like BMI (27% improvement, p<0.001), Waist Hip Ratio (p<0.002), Abdominal Girth Circumference (p<0.001), Chest Girth circumference (p<0.001), Waist circumference (p<0.001). The Fasting Blood Sugar (FBS) levels declined significantly from the mean (187.4 to 168.9, p<0.048), and PPBS reduced from the mean (260 to 230.4, p<0.011), which was statistically significant. However, HbA1c declined very marginally from the mean of 8.32 to 8.23 (p<0.71). Effect of treatment on subjective parameters like Apatarpana Lakshana, Dhatusamya Lakshana and Quality of Life parameters showed significant change. Conclusions: Administration of Abhaya Ghana Vati and Pathya Aahara Vihara are beneficial in patients of diabesity.
{"title":"Effect of <i>Abhaya Ghana Vati</i> along with <i>Pathya Aaahara Vihara</i> (Diet and Lifestyle Regime) on Patients of Diabesity – A Single Arm Clinical Trial","authors":"Aishwarya Ashish Joglekar, Mahesh Vyas, Meera K. Bhojani, Anil Kumar","doi":"10.18311/jnr/2023/32931","DOIUrl":"https://doi.org/10.18311/jnr/2023/32931","url":null,"abstract":"Introduction: Ayurveda beautifully amalgamates herbal drugs and lifestyle modifications in the management of various diseases and lifestyle disorders. Diabesity is one condition representing the two most prevalent chronic non-communicable diseases, i.e., Diabetes and Obesity According to Ayurveda, both conditions are referred to as Prameha and Sthoulya, respectively. Both the conditions are Santarpanottha Vyadhi (diseases arising from excessive and improper nutrition), having the common vitiation of Kapha Dosha, Meda Dhatu and Ama and similar lines of treatment. Haritaki or Abhaya (Terminalia chebula) is a herb that has the potential to manage both diabetes and obesity. The present study focuses on the efficacy of Abhaya Ghana Vati as a single drug regime coupled with Pathya Aahara Vihara (diet and lifestyle regime) in the management of diabesity. Methods: Abhaya Ghana Vati along with Pathya Aahara Vihara (diet and lifestyle regime), was administered in 41 patients for three months, including follow-up. The patients were assessed for the effect of the intervention on the subjective and objective criteria. Results: The intervention showed significant improvement in most of the parameters of outcome measures like BMI (27% improvement, p<0.001), Waist Hip Ratio (p<0.002), Abdominal Girth Circumference (p<0.001), Chest Girth circumference (p<0.001), Waist circumference (p<0.001). The Fasting Blood Sugar (FBS) levels declined significantly from the mean (187.4 to 168.9, p<0.048), and PPBS reduced from the mean (260 to 230.4, p<0.011), which was statistically significant. However, HbA1c declined very marginally from the mean of 8.32 to 8.23 (p<0.71). Effect of treatment on subjective parameters like Apatarpana Lakshana, Dhatusamya Lakshana and Quality of Life parameters showed significant change. Conclusions: Administration of Abhaya Ghana Vati and Pathya Aahara Vihara are beneficial in patients of diabesity.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"3 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136018317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Melasma is a pigmentary disorder hyperpigmentation primarily occurring on the cheeks, forehead, and bridge on the nose, upper lip, and occasionally elsewhere on the face. It is painless, superficial brownish macular patches. Modern science recommends laser therapy and various types of steroid use for treating melasma. Laser therapy is very expensive, and steroids have many side effects. So, in this study management of melasma has been done through Ayurveda, which is cost-effective, and easily available with the least side effects. From the signs and symptoms, melasma looks identical to Vyanga as per Ayurvedic texts that come under Kshudraroga (minor disease). In Ayurveda, external therapy Lepa (local application), is prescribed as one of the therapeutic measures for effectively managing melasma. A 32-year-old female patient was diagnosed clinically with melasma. She got treatment from a dermatologist and applied an allopathic care cream over the brownish patches. After regular application of the cream, a brownish patch does not decrease. She has no history of sunray exposure and has no family history. So, she went to Ayurvedic treatment. She was treated with Ayurvedic Lepa for local application and Panchanimbadi Churna internally for 21 days. The content of Ayurvedic Lepa was Nutmeg (Myristica fragrans Houtt.) Churna (powder), and Dugdha (milk). In ancient science, Nutmeg is known by the name of Jatiphala. Nutmeg is a very useful drug utilized therapeutically, and spice and Panchanimbadi are useful in all types of Raktavikara (blood disorders). The result was assessed with subjective and objective parameters, i.e., colour score and MASI score. After 21 days of treatment, significant changes were observed without any side effects. The colour score decreases from 3 to 1, and the MASI score from 15.2 to 10.1.
{"title":"Management of Melasma through <i>Ayurveda</i> – A Case Report","authors":"Dolly Kumari, Vaishali Chaudhari, Mamata Nakade, Pranesh Gaikwad, Snehalata Pawar","doi":"10.18311/jnr/2023/33342","DOIUrl":"https://doi.org/10.18311/jnr/2023/33342","url":null,"abstract":"Melasma is a pigmentary disorder hyperpigmentation primarily occurring on the cheeks, forehead, and bridge on the nose, upper lip, and occasionally elsewhere on the face. It is painless, superficial brownish macular patches. Modern science recommends laser therapy and various types of steroid use for treating melasma. Laser therapy is very expensive, and steroids have many side effects. So, in this study management of melasma has been done through Ayurveda, which is cost-effective, and easily available with the least side effects. From the signs and symptoms, melasma looks identical to Vyanga as per Ayurvedic texts that come under Kshudraroga (minor disease). In Ayurveda, external therapy Lepa (local application), is prescribed as one of the therapeutic measures for effectively managing melasma. A 32-year-old female patient was diagnosed clinically with melasma. She got treatment from a dermatologist and applied an allopathic care cream over the brownish patches. After regular application of the cream, a brownish patch does not decrease. She has no history of sunray exposure and has no family history. So, she went to Ayurvedic treatment. She was treated with Ayurvedic Lepa for local application and Panchanimbadi Churna internally for 21 days. The content of Ayurvedic Lepa was Nutmeg (Myristica fragrans Houtt.) Churna (powder), and Dugdha (milk). In ancient science, Nutmeg is known by the name of Jatiphala. Nutmeg is a very useful drug utilized therapeutically, and spice and Panchanimbadi are useful in all types of Raktavikara (blood disorders). The result was assessed with subjective and objective parameters, i.e., colour score and MASI score. After 21 days of treatment, significant changes were observed without any side effects. The colour score decreases from 3 to 1, and the MASI score from 15.2 to 10.1.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"597 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135979258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huzaifa Ansari, Athar Parvez Ansari, Pankaj Goswami, Ifra Qayoom, Abdul Hasib, Bazilah Majeed Reshi, Seema Akbar
Background and Objectives: Tadbīr va Islāh-i-Adwiya (detoxification/rectification of drugs) is a distinctive concept of Unani medicine in which drugs that are toxic by nature are detoxified before being administered to the human body. In Unani medicine, the resin called Saqmunia which is a derivative of the rhizome of Convolvulus scammonia, is used for therapeutic purposes. So far, limited research studies have been carried out to appraise the age-old concept of detoxification of Unani drugs. Therefore, the present study was designed to explore the physicochemical characteristics and acute toxicity of crude and detoxified samples of Saqmunia in albino Wistar rats. Methods: Saqmunia was detoxified through the tashwiya (roasting) method using apple and cow dung cakes. The physicochemical standardization includes moisture content, different ash values, extractive values; pH, fluorescence analysis, and TLC were performed. The acute toxicity study of both samples of Saqmunia was carried out at 300 and 2000 mg/kg dose levels in female albino Wistar rats. The data were analyzed using Oneway ANOVA followed by Dunnett’s comparison test. Results: The findings of the physicochemical standardization of crude and detoxified Saqmunia were found to be within an accepted range. The acute toxicity study has shown that the non-detoxified form of the test drug produced maximum toxicities, even causing death in rats. The LD50 of crude and detoxified Saqmunia was found to be 1000 mg and > 2000 mg/kg, respectively, in rats. Conclusions: The present study has suggested that Saqmunia used in this study was of good quality, and the physicochemical constants found in this study may be taken as a reference for future studies. Moreover, the acute toxicity study validates the Unani concept of detoxification of drugs, as is evident from the minimal toxic effects found in the detoxified sample of Saqmunia as compared to the crude sample in rats.
背景和目的:tadb r va Islāh-i-Adwiya(药物解毒/矫正)是乌干达医学的一个独特概念，其中性质有毒的药物在给予人体之前被解毒。在Unani医学中，一种叫做Saqmunia的树脂是Convolvulus sc氨根的衍生物，用于治疗目的。到目前为止，已经进行了有限的研究，以评价Unani药物解毒的古老概念。因此，本研究旨在探讨Saqmunia粗品和解毒品对白化Wistar大鼠的理化特性和急性毒性。方法:采用苹果粪饼和牛粪饼为原料，采用烤法解毒。理化标准包括水分含量、不同灰分值、萃取值;进行pH、荧光和薄层色谱分析。分别以300和2000 mg/kg剂量对雌性白化Wistar大鼠进行了Saqmunia样品的急性毒性研究。数据分析采用单因素方差分析和Dunnett比较检验。结果:粗、解毒菌理化标准均在可接受的范围内。急性毒性研究表明，试验药物的非解毒形式产生最大的毒性，甚至导致大鼠死亡。粗解菌的LD50分别为1000 mg和1000 mg;大鼠分别为2000 mg/kg。结论:本研究表明，本研究中使用的木香属植物质量较好，本研究中发现的理化常数可作为今后研究的参考。此外，急性毒性研究证实了Unani药物解毒的概念，这一点从Saqmunia解毒样本中发现的毒性作用与大鼠的粗样本相比是最小的。
{"title":"Comparative Physicochemical Evaluation and Acute Toxicity Study of Crude and Processed (Detoxified) Samples of <i>Saqmunia</i> (<i>Convolvulus scammonia</i> L.) in Albino Wistar Rats","authors":"Huzaifa Ansari, Athar Parvez Ansari, Pankaj Goswami, Ifra Qayoom, Abdul Hasib, Bazilah Majeed Reshi, Seema Akbar","doi":"10.18311/jnr/2023/33454","DOIUrl":"https://doi.org/10.18311/jnr/2023/33454","url":null,"abstract":"Background and Objectives: Tadbīr va Islāh-i-Adwiya (detoxification/rectification of drugs) is a distinctive concept of Unani medicine in which drugs that are toxic by nature are detoxified before being administered to the human body. In Unani medicine, the resin called Saqmunia which is a derivative of the rhizome of Convolvulus scammonia, is used for therapeutic purposes. So far, limited research studies have been carried out to appraise the age-old concept of detoxification of Unani drugs. Therefore, the present study was designed to explore the physicochemical characteristics and acute toxicity of crude and detoxified samples of Saqmunia in albino Wistar rats. Methods: Saqmunia was detoxified through the tashwiya (roasting) method using apple and cow dung cakes. The physicochemical standardization includes moisture content, different ash values, extractive values; pH, fluorescence analysis, and TLC were performed. The acute toxicity study of both samples of Saqmunia was carried out at 300 and 2000 mg/kg dose levels in female albino Wistar rats. The data were analyzed using Oneway ANOVA followed by Dunnett’s comparison test. Results: The findings of the physicochemical standardization of crude and detoxified Saqmunia were found to be within an accepted range. The acute toxicity study has shown that the non-detoxified form of the test drug produced maximum toxicities, even causing death in rats. The LD50 of crude and detoxified Saqmunia was found to be 1000 mg and > 2000 mg/kg, respectively, in rats. Conclusions: The present study has suggested that Saqmunia used in this study was of good quality, and the physicochemical constants found in this study may be taken as a reference for future studies. Moreover, the acute toxicity study validates the Unani concept of detoxification of drugs, as is evident from the minimal toxic effects found in the detoxified sample of Saqmunia as compared to the crude sample in rats.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"2023 187","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135979586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amal S. Chandran, Ashok Patil, Sanjiv Kumar, Krishika Muralidharan, Sreeja V. Kaimal
Background: Cardiorespiratory fitness is the capacity of the circulatory and respiratory systems to transport oxygen to the skeletal muscle mitochondria for energy production during physical activity. Cardiorespiratory fitness has been recognized as a vital health biomarker and is very crucial for sports persons. Physical activities, aerobic exercise, yoga, meditation, nutritional supplements, and ergogenic aids are the ways to enhance cardiorespiratory fitness. Emblica officinalis Gaertn. is one of the widely used drugs in Ayurveda traditional medicine to enhance Cardiorespiratory Fitness (CRF). However, there is a dearth of clear information regarding how Emblica officinalis can improve CRF. Objective: The current in silico molecular docking study was planned to identify the phytochemicals, and targets of endurance and predict the probable mode of action of the drug and thereby substantiate the ability of Emblica officinalis as a natural and ethical way of enhancing cardiorespiratory fitness. Methods: The phytochemicals and targets are collected from reliable sources, and the effectiveness of these gene targets was validated using network pharmacology ligand-target interaction methods. The Protein Data Bank and PubChem were used to find the ligands and targets, and PyRx was used to do docking. Conclusion: Emblica officinalis is found to have a positive influence on the 12 metabolic pathways that act in enhancing the cardiorespiratory endurance in the human being. PRKCA was analyzed and concluded as the highly modulated gene target with the lowest binding energy. Thus, Emblica officinalis was found to have an action in enhancing cardio-respiratory endurance.
背景:心肺健康是指在身体活动过程中，循环和呼吸系统向骨骼肌线粒体输送氧气以产生能量的能力。心肺适能已被公认为是一项重要的健康生物指标，对运动人士至关重要。体育活动、有氧运动、瑜伽、冥想、营养补充和促氧辅助都是增强心肺健康的方法。政府官员们都很高兴。是阿育吠陀传统医学中广泛使用的增强心肺功能(CRF)的药物之一。然而，关于Emblica officinalis如何改善CRF，缺乏明确的信息。目的:拟开展当前的硅分子对接研究，鉴定其植物化学物质和耐久靶点，预测其可能的作用方式，从而证实刺头草作为一种天然的、合乎伦理的增强心肺功能的方法。方法:从可靠来源收集植物化学物质和靶点，利用网络药理学方法对这些基因靶点的有效性进行验证。利用Protein Data Bank和PubChem寻找配体和靶标，利用PyRx进行对接。结论:乌刺对人体12条代谢途径均有积极影响，可增强人体心肺耐力。PRKCA被分析为结合能最低的高调控基因靶点。因此，我们发现恩布利亚具有增强心肺耐力的作用。
{"title":"<i>Emblica officinalis</i> Gaertn. (<i>Amalaki</i>): A Natural Herbal Remedy to Enhance Cardiorespiratory Fitness in <i>Ayurveda</i> - An <i>In Silico</i> Molecular Docking Approach","authors":"Amal S. Chandran, Ashok Patil, Sanjiv Kumar, Krishika Muralidharan, Sreeja V. Kaimal","doi":"10.18311/jnr/2023/34637","DOIUrl":"https://doi.org/10.18311/jnr/2023/34637","url":null,"abstract":"Background: Cardiorespiratory fitness is the capacity of the circulatory and respiratory systems to transport oxygen to the skeletal muscle mitochondria for energy production during physical activity. Cardiorespiratory fitness has been recognized as a vital health biomarker and is very crucial for sports persons. Physical activities, aerobic exercise, yoga, meditation, nutritional supplements, and ergogenic aids are the ways to enhance cardiorespiratory fitness. Emblica officinalis Gaertn. is one of the widely used drugs in Ayurveda traditional medicine to enhance Cardiorespiratory Fitness (CRF). However, there is a dearth of clear information regarding how Emblica officinalis can improve CRF. Objective: The current in silico molecular docking study was planned to identify the phytochemicals, and targets of endurance and predict the probable mode of action of the drug and thereby substantiate the ability of Emblica officinalis as a natural and ethical way of enhancing cardiorespiratory fitness. Methods: The phytochemicals and targets are collected from reliable sources, and the effectiveness of these gene targets was validated using network pharmacology ligand-target interaction methods. The Protein Data Bank and PubChem were used to find the ligands and targets, and PyRx was used to do docking. Conclusion: Emblica officinalis is found to have a positive influence on the 12 metabolic pathways that act in enhancing the cardiorespiratory endurance in the human being. PRKCA was analyzed and concluded as the highly modulated gene target with the lowest binding energy. Thus, Emblica officinalis was found to have an action in enhancing cardio-respiratory endurance.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135979583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
From the primitive era to the current generation, natural extracts or products played the most conservative therapeutic and nutritional resources. Starting from the era of folklore or ancient, mother nature has protected us from various diseases by producing various natural products having strong medicinal implications like quinine, taxol, vinblastine, etc. Among the many available sources of natural products, pharma-herb being a new member has drawn considerable attention of the researcher in order to have a new pool of products having pronounced pharmaceutical activity. Now Basella alba is one of the brightest candidates belonging to pharma-herb because of its considerably enriched pharmacologically important product stocks like vitamin C, flavonoid compounds, carotenoids, saponins as well as a large number of different minerals and numerous amino acids. This plant is a perennial vine that is often cultivated as a food crop during the cooler months. It is also able to grow very fast and can resist temperatures that are quite high. Basella alba has been referred to by a number of different names throughout history, including Indian-, Malabar-, climber-, Ceylon-, and vine-spinach. Poi is the term that the majority of people in India use when referring to it. The various natural products isolated from B. alba have significant medicinal utilization because of its antimicrobial, anti-ulcer, wound healing, antiviral, anti- inflammatory depressant, androgenic potential, hepatoprotective, antidiabetic, antioxidant, anti-anxiety, diuretic and antiurolithiatic activities. This review will cover a detailed journey about Basella alba L. ranging from phytochemical to toxicological, morphological, pharmacological as well as medicinal importance.
{"title":"Comprehensive Ethnomedicinal, Pharmacological and Phytochemical Report on <i>Basella alba</i> L. (Basellaceae)","authors":"Abhijit Bose, Sabyasachi Banerjee, Sudip Kumar Mandal, Sankhadip Bose, Subhasis Maity","doi":"10.18311/jnr/2023/34287","DOIUrl":"https://doi.org/10.18311/jnr/2023/34287","url":null,"abstract":"From the primitive era to the current generation, natural extracts or products played the most conservative therapeutic and nutritional resources. Starting from the era of folklore or ancient, mother nature has protected us from various diseases by producing various natural products having strong medicinal implications like quinine, taxol, vinblastine, etc. Among the many available sources of natural products, pharma-herb being a new member has drawn considerable attention of the researcher in order to have a new pool of products having pronounced pharmaceutical activity. Now Basella alba is one of the brightest candidates belonging to pharma-herb because of its considerably enriched pharmacologically important product stocks like vitamin C, flavonoid compounds, carotenoids, saponins as well as a large number of different minerals and numerous amino acids. This plant is a perennial vine that is often cultivated as a food crop during the cooler months. It is also able to grow very fast and can resist temperatures that are quite high. Basella alba has been referred to by a number of different names throughout history, including Indian-, Malabar-, climber-, Ceylon-, and vine-spinach. Poi is the term that the majority of people in India use when referring to it. The various natural products isolated from B. alba have significant medicinal utilization because of its antimicrobial, anti-ulcer, wound healing, antiviral, anti- inflammatory depressant, androgenic potential, hepatoprotective, antidiabetic, antioxidant, anti-anxiety, diuretic and antiurolithiatic activities. This review will cover a detailed journey about Basella alba L. ranging from phytochemical to toxicological, morphological, pharmacological as well as medicinal importance.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136134025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent studies suggest that curcumin has potent immunological activity in combination with ascorbic acid. Hence, research was carried out to formulate effervescent granules of curcumin and ascorbic acid as preventive measures for COVID-19. Thirteen formulas (F1 to F13) were prepared by applying 32 full factorial designs by applying the fusion method using Stat-Ease Design-Expert v7.0.0 software. Here, a complex of hydroxypropyl beta-cyclodextrin and curcumin was prepared by lyophilization technique to improve the solubility of curcumin. Citric acid, tartaric acid, sodium bicarbonate, polyethylene glycol, and sorbitol were used in the formulation of effervescent granules. Evaluation studies were carried out for all 13 formulas, including compatibility study, flowability study and effervescence time. The results show that granules have excellent flow property with an appropriate bulk density and tapped density for the uniting dose. The FTIR study also indicates that there is no interaction between excipients. The effervescence time is less than 3 minutes for all the batches. Formula 4 shows the best effervescence. This research article covers the development of effervescent granules containing curcumin, which has antiviral properties (both through direct movement on viruses and through modulating the immune system). With the pandemic of coronavirus that we are facing, curcumin and ascorbic acid can provide us protection against COVID-19 by keeping our immunity up and protecting against the onslaught of infections.
{"title":"Formulation, Optimization and Evaluation of Nutraceutical Effervescent Granules Containing Curcumin and Ascorbic Acid by Fusion Technique Using Full Factorial Design","authors":"Manisha Jadav, None Vikas Pal, Himanshi Pandit, Nikhil Suthar, Anand Pithadia, Lalit Lata Jha","doi":"10.18311/jnr/2023/33927","DOIUrl":"https://doi.org/10.18311/jnr/2023/33927","url":null,"abstract":"Recent studies suggest that curcumin has potent immunological activity in combination with ascorbic acid. Hence, research was carried out to formulate effervescent granules of curcumin and ascorbic acid as preventive measures for COVID-19. Thirteen formulas (F1 to F13) were prepared by applying 32 full factorial designs by applying the fusion method using Stat-Ease Design-Expert v7.0.0 software. Here, a complex of hydroxypropyl beta-cyclodextrin and curcumin was prepared by lyophilization technique to improve the solubility of curcumin. Citric acid, tartaric acid, sodium bicarbonate, polyethylene glycol, and sorbitol were used in the formulation of effervescent granules. Evaluation studies were carried out for all 13 formulas, including compatibility study, flowability study and effervescence time. The results show that granules have excellent flow property with an appropriate bulk density and tapped density for the uniting dose. The FTIR study also indicates that there is no interaction between excipients. The effervescence time is less than 3 minutes for all the batches. Formula 4 shows the best effervescence. This research article covers the development of effervescent granules containing curcumin, which has antiviral properties (both through direct movement on viruses and through modulating the immune system). With the pandemic of coronavirus that we are facing, curcumin and ascorbic acid can provide us protection against COVID-19 by keeping our immunity up and protecting against the onslaught of infections.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"62 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136319221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
None S. Umme Umaima, Kavitha G. Singh, None V. Veeraraghavan
Tyrosine ammonia lyase is an enzyme in the natural phenol biosynthesis pathway. L-tyrosine is deaminated to p-Coumaric acid with the help of the enzyme tyrosine ammonia lyase. Tyrosine Ammonia Lyase (TAL) is extracted from the leaves of Persea americana. Diosgenin involved in the inhibition of intracellular tyrosinase is extracted along with the enzyme Tyrosine Ammonia Lyase from leaves of Persea americana, significantly increasing the activity of Tyrosine Ammonia Lyase. Diosgenin in the current study on analysis is highly increasing the activity of enzymes. The ability of the enzyme along with diosgenin to increase the activity of the enzyme is analysed in the current study. The enzyme along with diosgenin is used for depigmentation of skin. The methodology of protein separation on treatment with acetone was utilized for the extraction of the enzyme. p-Coumaric acid formation detected using a UV-Visible spectrophotometer at 380nm confirmed the presence of the enzyme. Defatting followed by microwave-assisted extraction and ultrasound-assisted extraction methodology were used for the extraction of diosgenin from leaves of Persea americana. The role of diosgenin in increasing the activity of the enzyme was carried out by analysing the enzyme activity at 410nm. The enzyme-activating ability of diosgenin was compared with that of magnesium sulphate-purified Tyrosine Ammonia Lyase enzyme and sodium sulphate-purified Tyrosine Ammonia Lyase enzyme. Zebrafish embryos were used as model organisms for the conduction of in vivo studies. kojic acid was used as a control in the in vivo studies to compare the effect of the enzyme extracted along with the diosgenin with that of kojic acid.
{"title":"Extraction and Isolation of Tyrosine Ammonia Lyase (TAL) and Diosgenin from <i>Persea americana</i> as Potent Inhibitors of Melanin Synthesis Involving <i>In Vivo</i> Study on Zebrafish Embryos","authors":"None S. Umme Umaima, Kavitha G. Singh, None V. Veeraraghavan","doi":"10.18311/jnr/2023/33021","DOIUrl":"https://doi.org/10.18311/jnr/2023/33021","url":null,"abstract":"Tyrosine ammonia lyase is an enzyme in the natural phenol biosynthesis pathway. L-tyrosine is deaminated to p-Coumaric acid with the help of the enzyme tyrosine ammonia lyase. Tyrosine Ammonia Lyase (TAL) is extracted from the leaves of Persea americana. Diosgenin involved in the inhibition of intracellular tyrosinase is extracted along with the enzyme Tyrosine Ammonia Lyase from leaves of Persea americana, significantly increasing the activity of Tyrosine Ammonia Lyase. Diosgenin in the current study on analysis is highly increasing the activity of enzymes. The ability of the enzyme along with diosgenin to increase the activity of the enzyme is analysed in the current study. The enzyme along with diosgenin is used for depigmentation of skin. The methodology of protein separation on treatment with acetone was utilized for the extraction of the enzyme. p-Coumaric acid formation detected using a UV-Visible spectrophotometer at 380nm confirmed the presence of the enzyme. Defatting followed by microwave-assisted extraction and ultrasound-assisted extraction methodology were used for the extraction of diosgenin from leaves of Persea americana. The role of diosgenin in increasing the activity of the enzyme was carried out by analysing the enzyme activity at 410nm. The enzyme-activating ability of diosgenin was compared with that of magnesium sulphate-purified Tyrosine Ammonia Lyase enzyme and sodium sulphate-purified Tyrosine Ammonia Lyase enzyme. Zebrafish embryos were used as model organisms for the conduction of in vivo studies. kojic acid was used as a control in the in vivo studies to compare the effect of the enzyme extracted along with the diosgenin with that of kojic acid.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"37 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136319080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ashwini Dhananjay Sonalkar, Jayshree V. Changade, Dipa Ashok Jain
In India, cholelithiasis (gallstones) is now the leading problem. Some patients have a single gallstone, while others develop multiple gallstones at the same time. It could be as big as a golf ball or as small as a grain of sand. The risk factors for gallstones include middle age, inconsistent eating patterns, extended fasting, and metabolic syndrome. Surgical treatment is usually required, such as the removal of the entire gall bladder (cholecystectomy). In Ayurveda, it is not texted directly. There is a description of ashmari (urinary calculi), so by considering the symptoms and pathology of cholelithiasis, it can be correlated with pittashmari, as that site was given for Accha pitta according to the Ayurvedic classics. Pittashamri pathophysiology includes kapha-pitta vitiation and an obstructed Vayu marga (path). A 40-year-old male patient complained of pain in the upper abdomen along with bloating, chest discomfort, and constipation for the past 6 months. The patient had been taking modern medications. But patient experienced only temporary relief of symptoms. So, the patient came to the OPD for Ayurvedic treatment. Investigating with ultrasound, the patient was diagnosed with cholelithiasis and treated purely with herbal drugs as the patient was unaffordable. Pittarechaka (cholagogue), yakruta-pleehaghna, ashmarighna, and drugs with choleretic properties, such as kokilaksha, haritaki, bhumyamalaki, and rohitakarishta, were chosen. Within 15 days, the patient’s symptoms had significantly improved. The Numerical Rating Scale (NRS) was used to assess abdominal pain. A reduction in the size of the gallstone was seen within three months, and a completely normal ultrasound after one year, as discussed here.
{"title":"The Potential of Herbal Management in Gallstone (Pittashmari) – A Case Study","authors":"Ashwini Dhananjay Sonalkar, Jayshree V. Changade, Dipa Ashok Jain","doi":"10.18311/jnr/2023/33482","DOIUrl":"https://doi.org/10.18311/jnr/2023/33482","url":null,"abstract":"In India, cholelithiasis (gallstones) is now the leading problem. Some patients have a single gallstone, while others develop multiple gallstones at the same time. It could be as big as a golf ball or as small as a grain of sand. The risk factors for gallstones include middle age, inconsistent eating patterns, extended fasting, and metabolic syndrome. Surgical treatment is usually required, such as the removal of the entire gall bladder (cholecystectomy). In Ayurveda, it is not texted directly. There is a description of ashmari (urinary calculi), so by considering the symptoms and pathology of cholelithiasis, it can be correlated with pittashmari, as that site was given for Accha pitta according to the Ayurvedic classics. Pittashamri pathophysiology includes kapha-pitta vitiation and an obstructed Vayu marga (path). A 40-year-old male patient complained of pain in the upper abdomen along with bloating, chest discomfort, and constipation for the past 6 months. The patient had been taking modern medications. But patient experienced only temporary relief of symptoms. So, the patient came to the OPD for Ayurvedic treatment. Investigating with ultrasound, the patient was diagnosed with cholelithiasis and treated purely with herbal drugs as the patient was unaffordable. Pittarechaka (cholagogue), yakruta-pleehaghna, ashmarighna, and drugs with choleretic properties, such as kokilaksha, haritaki, bhumyamalaki, and rohitakarishta, were chosen. Within 15 days, the patient’s symptoms had significantly improved. The Numerical Rating Scale (NRS) was used to assess abdominal pain. A reduction in the size of the gallstone was seen within three months, and a completely normal ultrasound after one year, as discussed here.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"77 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136319222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. wallichiana DC, commonly known as camphor weed, is practically used in treatment of inflammatory disorders. Identification of kaempferol was done using High-Resolution Liquid Chromatography-Mass Spectrometry (HRLC-MS). High-Performance Thin-Layer Chromatography (HPTLC) method was performed and validated for the quantification of kaempferol. With a correlation coefficient of 0.997, the linearity range for kaempferol was 200 to 700 ng/spot. The suggested method had a recovery rate between 99.60 and 99.85 %. Limit of detection and Limit of quantification were determined to be 25 and 76.47 ng per spot, respectively. The amount of kaempferol was found to be 7.2% in ethyl acetate fraction of leaves. This is the first report of identification and quantification of kaempferol from P. wallichiana DC through HRLC-MS and HPTLC methods.
{"title":"Identification and Quantification of Kaempferol From Ethyl Acetate Fraction of Pluchea wallichiana DC Leaves","authors":"Kinjal Bera, Madhavi Patel","doi":"10.18311/jnr/2023/33208","DOIUrl":"https://doi.org/10.18311/jnr/2023/33208","url":null,"abstract":"P. wallichiana DC, commonly known as camphor weed, is practically used in treatment of inflammatory disorders. Identification of kaempferol was done using High-Resolution Liquid Chromatography-Mass Spectrometry (HRLC-MS). High-Performance Thin-Layer Chromatography (HPTLC) method was performed and validated for the quantification of kaempferol. With a correlation coefficient of 0.997, the linearity range for kaempferol was 200 to 700 ng/spot. The suggested method had a recovery rate between 99.60 and 99.85 %. Limit of detection and Limit of quantification were determined to be 25 and 76.47 ng per spot, respectively. The amount of kaempferol was found to be 7.2% in ethyl acetate fraction of leaves. This is the first report of identification and quantification of kaempferol from P. wallichiana DC through HRLC-MS and HPTLC methods.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47964175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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