A. Porwal, Gopal Kundu, G. Bhagwat, R. Nimma, Jayeeta Chowdhury
Anorectal problems such as anal fistula, Crohn’s disease, haemorrhoids, and fissures are prevalent across the general population. Severe discomfort, inflammation, swelling, itching, and bleeding during defecation are common symptoms of anorectal disorders. Depending on the severity of the condition, several medical therapies or surgical procedures may be used to treat these diseases. Surgical treatments like fistulectomy and sphincterotomy or haemorrhoidectomy are highly intrusive and have a risk of recurrence. Furthermore, surgical procedures cause pain, inflammation, and perineal sores. These will lead to severe socio-economic ramifications in the patient’s life. Therefore, treatment options that aid in the reduction of inflammation, pain, and perineal wounds are critical for anorectal disease management. Herbal formulations that comprise turmeric (Curcuma longa) extract have anti-inflammatory, pain-relieving, and wound-healing properties. The purpose of the current study was to elucidate the effect of Turmocin Plus on the infiltration of inflammatory cells and the expression of pro-angiogenic factors in anorectal and lower gastrointestinal disorders. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and wound migration assays were performed to determine the results of Turmocin Plus on the viability and migration of inflammatory cells. The effect of Turmocin Plus on pro-angiogenic factors was determined using Western blot analysis and immunofluorescence. Further, we validate our in vitro findings in human fistula specimens using IHC. The investigation showed that Turmocin Plus inhibits immunological (RAW 264.7) cell migration while maintaining their viability. Inflammation and increased levels of Vascular Endothelial Growth Factor (VEGF) were observed in Inflammatory Bowel Disease (IBD), fistula, fissures, and higher-grade haemorrhoids. However, Turmocin Plus suppresses the VEGF expression in macrophages (RAW 264.7) cells. Furthermore, compared to untreated human fistula tissues, decreased expression of VEGF was observed in Turmocin Plus treated patient samples, validating the in vitro findings. Our study suggests that Turmocin Plus is a potent therapeutic formulation in treating fistula, perineal wounds, and Crohn’s disease.
肛瘘、克罗恩病、痔疮和肛裂等肛门直肠问题在普通人群中普遍存在。排便时严重不适、发炎、肿胀、瘙痒和出血是肛门直肠疾病的常见症状。根据病情的严重程度，可采用多种药物疗法或外科手术来治疗这些疾病。肛瘘切除术、括约肌切开术或痔切除术等手术疗法具有很强的侵入性，而且有复发的风险。此外，手术治疗还会引起疼痛、炎症和会阴部溃疡。这些都会给患者的生活带来严重的社会经济影响。因此，有助于减轻炎症、疼痛和会阴伤口的治疗方案对于肛门直肠疾病的治疗至关重要。由姜黄（Curcuma longa）提取物组成的草药配方具有抗炎、止痛和伤口愈合的特性。本研究旨在阐明 Turmocin Plus 对肛门直肠和下消化道疾病中炎性细胞浸润和促血管生成因子表达的影响。通过 MTT（3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四唑溴化物）和伤口迁移试验来确定 Turmocin Plus 对炎性细胞活力和迁移的影响。通过 Western 印迹分析和免疫荧光测定了 Turmocin Plus 对促血管生成因子的影响。此外，我们还在人体瘘管标本中使用 IHC 验证了我们的体外研究结果。调查显示，Turmocin Plus 可抑制免疫细胞（RAW 264.7）迁移，同时保持其活力。在炎症性肠病（IBD）、瘘管、肛裂和高位痔疮中观察到了炎症和血管内皮生长因子（VEGF）水平的升高。然而，Turmocin Plus 能抑制巨噬细胞（RAW 264.7）中血管内皮生长因子的表达。此外，与未经处理的人体瘘管组织相比，Turmocin Plus 处理过的患者样本中血管内皮生长因子的表达有所下降，这验证了体外研究结果。我们的研究表明，Turmocin Plus 是一种治疗瘘管、会阴伤口和克罗恩病的有效制剂。
{"title":"Turmocin Plus Suppresses Vascular Endothelial Growth Factor (VEGF) and Macrophage Infiltration in the Management of Perineal Wounds, Anal Fistula, Acute Anal Fissures and Haemorrhoids","authors":"A. Porwal, Gopal Kundu, G. Bhagwat, R. Nimma, Jayeeta Chowdhury","doi":"10.18311/jnr/2024/33298","DOIUrl":"https://doi.org/10.18311/jnr/2024/33298","url":null,"abstract":"Anorectal problems such as anal fistula, Crohn’s disease, haemorrhoids, and fissures are prevalent across the general population. Severe discomfort, inflammation, swelling, itching, and bleeding during defecation are common symptoms of anorectal disorders. Depending on the severity of the condition, several medical therapies or surgical procedures may be used to treat these diseases. Surgical treatments like fistulectomy and sphincterotomy or haemorrhoidectomy are highly intrusive and have a risk of recurrence. Furthermore, surgical procedures cause pain, inflammation, and perineal sores. These will lead to severe socio-economic ramifications in the patient’s life. Therefore, treatment options that aid in the reduction of inflammation, pain, and perineal wounds are critical for anorectal disease management. Herbal formulations that comprise turmeric (Curcuma longa) extract have anti-inflammatory, pain-relieving, and wound-healing properties. The purpose of the current study was to elucidate the effect of Turmocin Plus on the infiltration of inflammatory cells and the expression of pro-angiogenic factors in anorectal and lower gastrointestinal disorders. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and wound migration assays were performed to determine the results of Turmocin Plus on the viability and migration of inflammatory cells. The effect of Turmocin Plus on pro-angiogenic factors was determined using Western blot analysis and immunofluorescence. Further, we validate our in vitro findings in human fistula specimens using IHC. The investigation showed that Turmocin Plus inhibits immunological (RAW 264.7) cell migration while maintaining their viability. Inflammation and increased levels of Vascular Endothelial Growth Factor (VEGF) were observed in Inflammatory Bowel Disease (IBD), fistula, fissures, and higher-grade haemorrhoids. However, Turmocin Plus suppresses the VEGF expression in macrophages (RAW 264.7) cells. Furthermore, compared to untreated human fistula tissues, decreased expression of VEGF was observed in Turmocin Plus treated patient samples, validating the in vitro findings. Our study suggests that Turmocin Plus is a potent therapeutic formulation in treating fistula, perineal wounds, and Crohn’s disease.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"82 3‐4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes is a metabolic disorder with many different underlying factors. Humans can develop Type 1 diabetes, which is brought on when the immune system assaults and destroys insulin, and Type 2 diabetes, which can be brought on by several variables, the most important of which is lifestyle, as well as by different genotypes. Due to the presence of polyphenols, which have high antioxidant qualities, Coconut Palm Sugar (CPS) is nutritious and has a good potential for managing diabetes. In this investigation, we took the STZ-Nicotinamide model for diabetes induction. In normal rats (Phase 1) and diabetes-induced rats (Phase 2), After exposure to table sugar and coconut palm sugar, we measured a variety of factors, including body weight, food intake, water consumption, blood sugar level, insulin level, insulin resistance, lipid profile, atherogenic index, and insulin resistance.
{"title":"Investigation of the Effect of Coconut Palm Sugar on Metabolic Disorders in Experimental Diabetic Rats","authors":"Shraddha Patel, Archana Navale","doi":"10.18311/jnr/2024/35036","DOIUrl":"https://doi.org/10.18311/jnr/2024/35036","url":null,"abstract":"Diabetes is a metabolic disorder with many different underlying factors. Humans can develop Type 1 diabetes, which is brought on when the immune system assaults and destroys insulin, and Type 2 diabetes, which can be brought on by several variables, the most important of which is lifestyle, as well as by different genotypes. Due to the presence of polyphenols, which have high antioxidant qualities, Coconut Palm Sugar (CPS) is nutritious and has a good potential for managing diabetes. In this investigation, we took the STZ-Nicotinamide model for diabetes induction. In normal rats (Phase 1) and diabetes-induced rats (Phase 2), After exposure to table sugar and coconut palm sugar, we measured a variety of factors, including body weight, food intake, water consumption, blood sugar level, insulin level, insulin resistance, lipid profile, atherogenic index, and insulin resistance.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"107 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139826247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diabetes is a metabolic disorder with many different underlying factors. Humans can develop Type 1 diabetes, which is brought on when the immune system assaults and destroys insulin, and Type 2 diabetes, which can be brought on by several variables, the most important of which is lifestyle, as well as by different genotypes. Due to the presence of polyphenols, which have high antioxidant qualities, Coconut Palm Sugar (CPS) is nutritious and has a good potential for managing diabetes. In this investigation, we took the STZ-Nicotinamide model for diabetes induction. In normal rats (Phase 1) and diabetes-induced rats (Phase 2), After exposure to table sugar and coconut palm sugar, we measured a variety of factors, including body weight, food intake, water consumption, blood sugar level, insulin level, insulin resistance, lipid profile, atherogenic index, and insulin resistance.
{"title":"Investigation of the Effect of Coconut Palm Sugar on Metabolic Disorders in Experimental Diabetic Rats","authors":"Shraddha Patel, Archana Navale","doi":"10.18311/jnr/2024/35036","DOIUrl":"https://doi.org/10.18311/jnr/2024/35036","url":null,"abstract":"Diabetes is a metabolic disorder with many different underlying factors. Humans can develop Type 1 diabetes, which is brought on when the immune system assaults and destroys insulin, and Type 2 diabetes, which can be brought on by several variables, the most important of which is lifestyle, as well as by different genotypes. Due to the presence of polyphenols, which have high antioxidant qualities, Coconut Palm Sugar (CPS) is nutritious and has a good potential for managing diabetes. In this investigation, we took the STZ-Nicotinamide model for diabetes induction. In normal rats (Phase 1) and diabetes-induced rats (Phase 2), After exposure to table sugar and coconut palm sugar, we measured a variety of factors, including body weight, food intake, water consumption, blood sugar level, insulin level, insulin resistance, lipid profile, atherogenic index, and insulin resistance.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"149 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Greeshma, R. Thamizselvi, S. Muthulingam, Sam John, Dhanya B. Sen
Nowadays, most antiviral drugs are plant-based due to their low toxicity and high resistance. Morinda citrifolia (Noni) is such a perennial shrub a popular plant based medicine due to its wide therapeutic applications. The phytochemicals present in its fruit as well as its leaf have many antiviral properties and can enhance the human immune system. Herein, we report the identification of bioactive components present in the Morinda citrifolia (Noni) ethanolic leaf extract by GC-MS analysis and their biological interaction with human parallel-stranded 7-mer g-quadruplex DNA of MCF-7 using Biovia Discovery Studio software. In vitro analysis by MTT assay of the same extract reported a living cells of 59.74% at 100 µg/ml. The GC-MS analysis of ethanolic leaf extract revealed the presence of 27 bioactive components, and out of these, six major components were interacted with cancer DNA. The molecular docking interaction identified the most active bio component Phytol, with a binding energy of -27.0796 Kcal/mol. this value is much better than the commercially available doxorubicin. This novel study will provide insight into the development of bioactive components from Morinda citrifolia leaf extract against human breast cancer with minimal side effects.
如今，大多数抗病毒药物都以植物为基础，因为它们毒性低、抗药性强。诺丽果（Morinda citrifolia）就是这样一种多年生灌木，因其广泛的治疗用途而成为一种流行的植物性药物。其果实和叶片中的植物化学物质具有多种抗病毒特性，并能增强人体免疫系统。在此，我们利用 Biovia Discovery Studio 软件，通过气相色谱-质谱（GC-MS）分析鉴定了海巴戟（诺丽）乙醇叶提取物中的生物活性成分，以及它们与 MCF-7 的人体平行链 7-mer g-quadruplex DNA 的生物相互作用。用 MTT 法对同一提取物进行体外分析，结果表明在 100 µg/ml 的浓度下，活细胞率为 59.74%。乙醇叶提取物的气相色谱-质谱（GC-MS）分析表明，其中含有 27 种生物活性成分，其中六种主要成分与癌症 DNA 有相互作用。分子对接相互作用确定了最具活性的生物成分植物醇，其结合能为 -27.0796 Kcal/mol。这项新颖的研究将为开发海巴戟叶提取物中的生物活性成分提供深入的见解，从而在最小的副作用下对抗人类乳腺癌。
{"title":"A Study on Biologically Active Components in Morinda citrifolia Leaf Extract and its Anti-cancer Effect by In Vitro Analysis and In Silico Molecular Docking Method","authors":"K. Greeshma, R. Thamizselvi, S. Muthulingam, Sam John, Dhanya B. Sen","doi":"10.18311/jnr/2024/33868","DOIUrl":"https://doi.org/10.18311/jnr/2024/33868","url":null,"abstract":"Nowadays, most antiviral drugs are plant-based due to their low toxicity and high resistance. Morinda citrifolia (Noni) is such a perennial shrub a popular plant based medicine due to its wide therapeutic applications. The phytochemicals present in its fruit as well as its leaf have many antiviral properties and can enhance the human immune system. Herein, we report the identification of bioactive components present in the Morinda citrifolia (Noni) ethanolic leaf extract by GC-MS analysis and their biological interaction with human parallel-stranded 7-mer g-quadruplex DNA of MCF-7 using Biovia Discovery Studio software. In vitro analysis by MTT assay of the same extract reported a living cells of 59.74% at 100 µg/ml. The GC-MS analysis of ethanolic leaf extract revealed the presence of 27 bioactive components, and out of these, six major components were interacted with cancer DNA. The molecular docking interaction identified the most active bio component Phytol, with a binding energy of -27.0796 Kcal/mol. this value is much better than the commercially available doxorubicin. This novel study will provide insight into the development of bioactive components from Morinda citrifolia leaf extract against human breast cancer with minimal side effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"35 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sagar F. Magar, Mamata Nakade, Rahul Kshirsagar, Snehalata Pawar
Oligospermia is one of the most common reasons for infertility in day-to-day life. Infertility is a widespread issue that affects 8-12 % of couples globally on average and is getting worse day by day. It was observed that the pathology is found in approximately incidence of 60% males alone in infertile couples. In Ayurveda, Oligospermia can be correlated with Shukra-Alpta. Bastikarma is considered to be having particular action on Shukra Dhatu and Chatuprasrutik Basti is explained as Shukrakrut Basti in Charak Samhita, So in this study, Chatuprasrutik Basti was selected in the management of Oligospermia. Aim: This clinical investigation looked into how Chatuprasrutik Basti affected the number of sperm in patients with infertility. Study Design: This was interventional clinical research with one arm. Materials and Methods: Chatuprasrutik Basti was administered for two cycles of Basti of 6 days each with a month gap in Seven newly diagnosed cases of Oligospermia from the outpatient Department of Panchakarma at SST’s Ayurved Mahavidyalaya in, Sangamner, Ahmednagar, Maharashtra, India. Statistical Analysis: The “Student paired t-test” was used statistically to analyze the data. Results: At the conclusion of therapy, a significant (p<0.05) result was found in the evaluation of an objective parameter, specifically sperm count, and a significant result was not found in the evaluation of the factor sperm motility as p>0.05. Conclusion: Chatuprasrutik Basti is effective in the management of Oligospermia considering the factor of sperm count.
{"title":"Efficacy of Chatuprasrutik Basti in Management Of Oligospermia – A Pilot Study","authors":"Sagar F. Magar, Mamata Nakade, Rahul Kshirsagar, Snehalata Pawar","doi":"10.18311/jnr/2024/35339","DOIUrl":"https://doi.org/10.18311/jnr/2024/35339","url":null,"abstract":"Oligospermia is one of the most common reasons for infertility in day-to-day life. Infertility is a widespread issue that affects 8-12 % of couples globally on average and is getting worse day by day. It was observed that the pathology is found in approximately incidence of 60% males alone in infertile couples. In Ayurveda, Oligospermia can be correlated with Shukra-Alpta. Bastikarma is considered to be having particular action on Shukra Dhatu and Chatuprasrutik Basti is explained as Shukrakrut Basti in Charak Samhita, So in this study, Chatuprasrutik Basti was selected in the management of Oligospermia.\u0000Aim: This clinical investigation looked into how Chatuprasrutik Basti affected the number of sperm in patients with infertility.\u0000Study Design: This was interventional clinical research with one arm.\u0000Materials and Methods: Chatuprasrutik Basti was administered for two cycles of Basti of 6 days each with a month gap in Seven newly diagnosed cases of Oligospermia from the outpatient Department of Panchakarma at SST’s Ayurved Mahavidyalaya in, Sangamner, Ahmednagar, Maharashtra, India.\u0000Statistical Analysis: The “Student paired t-test” was used statistically to analyze the data.\u0000Results: At the conclusion of therapy, a significant (p<0.05) result was found in the evaluation of an objective parameter, specifically sperm count, and a significant result was not found in the evaluation of the factor sperm motility as p>0.05.\u0000Conclusion: Chatuprasrutik Basti is effective in the management of Oligospermia considering the factor of sperm count.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"70 1-2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139893114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our country has a wealth of Ayurvedic expertise, but only recently has its full potential been recognized. Any herbal medication’s efficacy depends on the medically active substance being delivered at an effective dosage. When given directly or externally, their bioavailability is severely constrained. With increased effectiveness, quality, and enhancement of active plant components, phytosome technology has evolved as a dedicated and hopeful means of delivering new drugs. Traditional herbal remedies have been used for a long time to successfully treat various types of illnesses, but their effectiveness has often been limited by the difficulty of getting the active compounds to their intended targets in the body. However, recent advances in herbal formulation technology have made it possible to create more efficient and targeted delivery systems for these compounds. This study emphasizes the special qualities of the phyto-phospholipid complex and how they are used in cutting-edge natural drug administration. The emphasis of the current review is on phytosome production and characterization methods, benefits, and significant developments.
{"title":"Phytosomes: A Contemporary Method for Delivering Novel Herbal Drugs","authors":"Divya Kanojiya, Ghanshyam Parmar, Bhavik Chauhan, Shamana Gondalia, Monika Rakholiya","doi":"10.18311/jnr/2024/34470","DOIUrl":"https://doi.org/10.18311/jnr/2024/34470","url":null,"abstract":"Our country has a wealth of Ayurvedic expertise, but only recently has its full potential been recognized. Any herbal medication’s efficacy depends on the medically active substance being delivered at an effective dosage. When given directly or externally, their bioavailability is severely constrained. With increased effectiveness, quality, and enhancement of active plant components, phytosome technology has evolved as a dedicated and hopeful means of delivering new drugs. Traditional herbal remedies have been used for a long time to successfully treat various types of illnesses, but their effectiveness has often been limited by the difficulty of getting the active compounds to their intended targets in the body. However, recent advances in herbal formulation technology have made it possible to create more efficient and targeted delivery systems for these compounds. This study emphasizes the special qualities of the phyto-phospholipid complex and how they are used in cutting-edge natural drug administration. The emphasis of the current review is on phytosome production and characterization methods, benefits, and significant developments.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139878920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Oppong Bekoe, Emmanuel Orman, Michael Lartey, Andrew Gordon, Tonny Asafo-Agyei
Polyalthia longifolia (Sonn.) is a medicinal plant that belongs to the family Annonaceae, and it is distributed in the tropics. This plant is widely grown in West Africa for its ornamental and medicinal purposes. There are two varieties of P. longifolia which are commonly distinguishable by the direction of their branches. One has spreading perpendicular branches, and the other has drooping pendulous branches. Traditional herbal practitioners believe that one variety (P. longifolia cv. pendula) is more medicinal than the other. This study, therefore, sought to investigate the phytochemical components of the two varieties of P. longifolia by HPTLC, UPLC, and elemental analysis by ICP-EOS. No observable differences were found in the phytochemical and elemental profiles of these varieties that could help distinguish one from the other or could account for its supposed differences in medicinal properties. A total of 22 elements were detected in the samples of the two varieties of the plant. Qualitatively, the elemental content of both varieties was similar. Only Iridium was not detected in all samples. Heavy metals including As, Pb, Cd, and Hg had their levels above the recommended limits.
{"title":"Phytochemical Analysis and Elemental Contents of Varieties of Polyalthia longifolia (Sonn.) Thwaites","authors":"E. Oppong Bekoe, Emmanuel Orman, Michael Lartey, Andrew Gordon, Tonny Asafo-Agyei","doi":"10.18311/jnr/2024/32921","DOIUrl":"https://doi.org/10.18311/jnr/2024/32921","url":null,"abstract":"Polyalthia longifolia (Sonn.) is a medicinal plant that belongs to the family Annonaceae, and it is distributed in the tropics. This plant is widely grown in West Africa for its ornamental and medicinal purposes. There are two varieties of P. longifolia which are commonly distinguishable by the direction of their branches. One has spreading perpendicular branches, and the other has drooping pendulous branches. Traditional herbal practitioners believe that one variety (P. longifolia cv. pendula) is more medicinal than the other. This study, therefore, sought to investigate the phytochemical components of the two varieties of P. longifolia by HPTLC, UPLC, and elemental analysis by ICP-EOS. No observable differences were found in the phytochemical and elemental profiles of these varieties that could help distinguish one from the other or could account for its supposed differences in medicinal properties. A total of 22 elements were detected in the samples of the two varieties of the plant. Qualitatively, the elemental content of both varieties was similar. Only Iridium was not detected in all samples. Heavy metals including As, Pb, Cd, and Hg had their levels above the recommended limits.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"26 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Our country has a wealth of Ayurvedic expertise, but only recently has its full potential been recognized. Any herbal medication’s efficacy depends on the medically active substance being delivered at an effective dosage. When given directly or externally, their bioavailability is severely constrained. With increased effectiveness, quality, and enhancement of active plant components, phytosome technology has evolved as a dedicated and hopeful means of delivering new drugs. Traditional herbal remedies have been used for a long time to successfully treat various types of illnesses, but their effectiveness has often been limited by the difficulty of getting the active compounds to their intended targets in the body. However, recent advances in herbal formulation technology have made it possible to create more efficient and targeted delivery systems for these compounds. This study emphasizes the special qualities of the phyto-phospholipid complex and how they are used in cutting-edge natural drug administration. The emphasis of the current review is on phytosome production and characterization methods, benefits, and significant developments.
{"title":"Phytosomes: A Contemporary Method for Delivering Novel Herbal Drugs","authors":"Divya Kanojiya, Ghanshyam Parmar, Bhavik Chauhan, Shamana Gondalia, Monika Rakholiya","doi":"10.18311/jnr/2024/34470","DOIUrl":"https://doi.org/10.18311/jnr/2024/34470","url":null,"abstract":"Our country has a wealth of Ayurvedic expertise, but only recently has its full potential been recognized. Any herbal medication’s efficacy depends on the medically active substance being delivered at an effective dosage. When given directly or externally, their bioavailability is severely constrained. With increased effectiveness, quality, and enhancement of active plant components, phytosome technology has evolved as a dedicated and hopeful means of delivering new drugs. Traditional herbal remedies have been used for a long time to successfully treat various types of illnesses, but their effectiveness has often been limited by the difficulty of getting the active compounds to their intended targets in the body. However, recent advances in herbal formulation technology have made it possible to create more efficient and targeted delivery systems for these compounds. This study emphasizes the special qualities of the phyto-phospholipid complex and how they are used in cutting-edge natural drug administration. The emphasis of the current review is on phytosome production and characterization methods, benefits, and significant developments.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139818753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, Sourav Guha
Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.
{"title":"Evaluating the Effect of Moringa concanensis on Aluminium Chloride-Induced Anemia in Wistar Rats","authors":"Rahul Kumar, M. G. Hariprasad, Moqbel Ali Moqbel Redhwan, Vidyabhushan Yadav, Apurwa Dhavale, Sourav Guha","doi":"10.18311/jnr/2024/34553","DOIUrl":"https://doi.org/10.18311/jnr/2024/34553","url":null,"abstract":"Anemia, a widespread global health challenge, can be induced through exposure to deleterious substances such as aluminum chloride. The present investigation explores the potential ameliorative effects of Moringa concanensis - a plant acknowledged for its myriad medicinal virtues-against anemia induced by aluminium chloride. The study objective was to scrutinize the impact of Moringa concanensis on aluminium chloride-induced anemia in Wistar rats. In the experimental design, thirty Wistar rats were randomly distributed into five distinct groups: a normal control group (untreated), a diseased control group (administered with aluminium chloride at a dose of 0.5 mg/kg body weight), a standard group (treated with Ferrous ascorbate at 30 mg/kg body weight), and two groups receiving low and high doses of Moringa concanensis (200 mg/kg and 400 mg/kg body weight, respectively). All groups, with the exception of the normal control, were exposed to aluminium chloride at a dosage of 0.5 mg/kg body weight over a span of 14 days. Hematological indicators were evaluated following standard methodologies, serum ferritin levels were assessed through Electrochemiluminescence immunoassay (ECLIA), and vitamin B12 concentration was quantified using atomic absorption spectroscopy. Furthermore, histopathological alterations were identified through Hematoxylin and Eosin staining procedures. Statistical data were interpreted through one-way ANOVA, succeeded by Tukey’s post hoc analysis, considering a p-value below 0.05 as statistically significant. Upon 21 days of continuous treatment with Moringa concanensis, both low and high-dose groups exhibited elevation in hematological parameters, serum ferritin, total iron-binding capacity, and vitamin B12 in comparison to the diseased control group. Noteworthy findings were observed in the high-dose group (400 mg/kg body weight), displaying significant improvement compared to the diseased control group (P<0.001). Remarkably, the high-dose regimen restored hematological parameters to baseline levels and mirrored the efficacy observed with the standard drug (Ferrous ascorbate). These empirical findings underscore the potential of Moringa concanensis as a promising therapeutic candidate for the alleviation of aluminium chloride-induced anemia. These results pave the way for future research endeavors to unravel the precise mechanisms driving these protective effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"421 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139824878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piyush Chaudhary, B. Rathi, N. Lamba, Anil Sharma, Renu Rathi
Drug standardisation, profiling, and quality control continue to be a challenge for Ayurvedic medicines due to their wide range of dosage forms. Different dosage forms like decoctions and powders result in non-compliance from the patient owing to their palatability or cumbersome methods of administration. The present study aims to pharmaceutically process a traditional decoction, Phalatrikadi Kwatha, and standardise it into tablet form, known as Phalatrikadi Ghana Vati (PGV). PGV was prepared and subjected to organoleptic, physicochemical, phytochemical analysis, and HPTLC analysis in an attempt to define its quality parameters and standardisation. Distinct fingerprints of Phalatrikadi Ghana Vati were obtained. Out of the eight components identified, the components with Rf values 0.08, 0.74, 0.65 and 0.83 were more predominant with more percent areas 9.65%, 14.91%, 18.02%, and 40.67%, respectively Quantitative physicochemical analysis revealed loss on drying as 1.33%, ash value as 4.53%, water-soluble extractive as 15.38%, alcohol extractive as 9.63% and pH as 5.1. The study also revealed the presence of alkaloids, glycosides, flavonoids, amino acids, and saponins. Preliminary profiling of PGV exhibited striking analytical characteristics. The physicochemical parameters were in the range of a standard tablet. The quantitative physicochemical parameters and HPTLC profile can be used as a reference standard for the quality control of Phalatrikadi Ghan Vati.
{"title":"Standardisation and Quality Control Parameters of Phalatrikadi Ghana Vati – An Ayurvedic Formulation","authors":"Piyush Chaudhary, B. Rathi, N. Lamba, Anil Sharma, Renu Rathi","doi":"10.18311/jnr/2024/35126","DOIUrl":"https://doi.org/10.18311/jnr/2024/35126","url":null,"abstract":"Drug standardisation, profiling, and quality control continue to be a challenge for Ayurvedic medicines due to their wide range of dosage forms. Different dosage forms like decoctions and powders result in non-compliance from the patient owing to their palatability or cumbersome methods of administration. The present study aims to pharmaceutically process a traditional decoction, Phalatrikadi Kwatha, and standardise it into tablet form, known as Phalatrikadi Ghana Vati (PGV). PGV was prepared and subjected to organoleptic, physicochemical, phytochemical analysis, and HPTLC analysis in an attempt to define its quality parameters and standardisation. Distinct fingerprints of Phalatrikadi Ghana Vati were obtained. Out of the eight components identified, the components with Rf values 0.08, 0.74, 0.65 and 0.83 were more predominant with more percent areas 9.65%, 14.91%, 18.02%, and 40.67%, respectively Quantitative physicochemical analysis revealed loss on drying as 1.33%, ash value as 4.53%, water-soluble extractive as 15.38%, alcohol extractive as 9.63% and pH as 5.1. The study also revealed the presence of alkaloids, glycosides, flavonoids, amino acids, and saponins. Preliminary profiling of PGV exhibited striking analytical characteristics. The physicochemical parameters were in the range of a standard tablet. The quantitative physicochemical parameters and HPTLC profile can be used as a reference standard for the quality control of Phalatrikadi Ghan Vati.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"39 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139825863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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