Over the past few decades, obesity has become an increasingly prevalent issue around the world. Increased incidence of obesity in society is a result of poor food, exercise habits and a lack of awareness. Diet, exercise and behavioural modifications form the cornerstone of the therapy. Significant comorbidities have been associated with childhood obesity. The main Ayurvedic texts like Samhita and Nighantu along with modern texts are referred to collect information on relevant topics. This article is based on a review of various Ayurvedic principles and modern concepts related to Sthaulya vyadhi and obesity respectively. The description of Sthaulya vyadhi mentioned in Ayurveda classics is quite similar to obesity. Ayurveda management of Sthaulya (obesity) is different from contemporary science as it includes medovaha strotas chikitsa with dietary modification. Drug pharmacodynamics (Ayurveda rasa panchaka) and reported actions on Lekhaniya (Scrapping property) drugs to give an idea of the potential of Ayurveda to treat the disease efficiently. The potential of Ayurvedic drugs for treating obesity is underutilised and this could be a great alternative approach for creating future effective, reliable anti-obesity medications.
{"title":"Role of Lekhaniya and Vachadi gana in Childhood Obesity - Critical Review","authors":"Kuldeep Katare, Rahul Katkar, S. Acharya","doi":"10.18311/jnr/2024/33795","DOIUrl":"https://doi.org/10.18311/jnr/2024/33795","url":null,"abstract":"Over the past few decades, obesity has become an increasingly prevalent issue around the world. Increased incidence of obesity in society is a result of poor food, exercise habits and a lack of awareness. Diet, exercise and behavioural modifications form the cornerstone of the therapy. Significant comorbidities have been associated with childhood obesity. The main Ayurvedic texts like Samhita and Nighantu along with modern texts are referred to collect information on relevant topics. This article is based on a review of various Ayurvedic principles and modern concepts related to Sthaulya vyadhi and obesity respectively. The description of Sthaulya vyadhi mentioned in Ayurveda classics is quite similar to obesity. Ayurveda management of Sthaulya (obesity) is different from contemporary science as it includes medovaha strotas chikitsa with dietary modification. Drug pharmacodynamics (Ayurveda rasa panchaka) and reported actions on Lekhaniya (Scrapping property) drugs to give an idea of the potential of Ayurveda to treat the disease efficiently. The potential of Ayurvedic drugs for treating obesity is underutilised and this could be a great alternative approach for creating future effective, reliable anti-obesity medications.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"267 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Shalini, R. S. Parvathy, I. Sundara Ganesh, P. S. Devika, V. D. Selvam
Psoriasis is a non-infectious and chronic inflammatory skin disorder that is characterized by well-defined erythematous plaques with silvery scales over the epidermis. It significantly affects a patient’s social and psychological well-being. Contemporary medicine offers no definitive treatment. However, corticosteroids are the drug of choice for treating psoriasis. Currently, available therapeutics cause severe side effects on the body. In the Siddha system of medicine, psoriasis can be compared with Kalanjagapadai, because most of the signs and symptoms mimic that of Plaque psoriasis. However, the principle based on the Siddha medicine approach has proven to be effective. This article presents a case of psoriasis treated for 3 months with Siddha herbo-mineral preparations and dietary restrictions. A 40-year-old male patient presented with complaints of well-defined erythematous itchy skin lesion, burning sensation, and silvery scaling all over the body for the past 3 months. Based on the symptoms Kalanjagapadai treatment was adopted here. After giving purgation therapy (Viresanam), and internal and external medications, the patient’s erythema, itching, and scaling symptoms subsided. The Psoriasis Area and Severity Index (PASI) score was decreased. Although psoriasis is intricate to treat, Siddha treatment has proven to be beneficial when using appropriate medications and therapies. In this case report, attempts were given for further scope on Psoriasis in wide-based extensive clinical trials.
{"title":"Cost-effective Siddha Management of Psoriasis Vulgaris with Special Reference to Kalanjagapadai – A Case Report","authors":"V. Shalini, R. S. Parvathy, I. Sundara Ganesh, P. S. Devika, V. D. Selvam","doi":"10.18311/jnr/2024/34647","DOIUrl":"https://doi.org/10.18311/jnr/2024/34647","url":null,"abstract":"Psoriasis is a non-infectious and chronic inflammatory skin disorder that is characterized by well-defined erythematous plaques with silvery scales over the epidermis. It significantly affects a patient’s social and psychological well-being. Contemporary medicine offers no definitive treatment. However, corticosteroids are the drug of choice for treating psoriasis. Currently, available therapeutics cause severe side effects on the body. In the Siddha system of medicine, psoriasis can be compared with Kalanjagapadai, because most of the signs and symptoms mimic that of Plaque psoriasis. However, the principle based on the Siddha medicine approach has proven to be effective. This article presents a case of psoriasis treated for 3 months with Siddha herbo-mineral preparations and dietary restrictions. A 40-year-old male patient presented with complaints of well-defined erythematous itchy skin lesion, burning sensation, and silvery scaling all over the body for the past 3 months. Based on the symptoms Kalanjagapadai treatment was adopted here. After giving purgation therapy (Viresanam), and internal and external medications, the patient’s erythema, itching, and scaling symptoms subsided. The Psoriasis Area and Severity Index (PASI) score was decreased. Although psoriasis is intricate to treat, Siddha treatment has proven to be beneficial when using appropriate medications and therapies. In this case report, attempts were given for further scope on Psoriasis in wide-based extensive clinical trials.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"3 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Manju Tripathi, V. B. Adsul, E. Khatiwora, M. P. Wadekar, S. A. Gaikwad
Objective: The present study investigates the anthelmintic potential of Amaranthus viridis Linn. and Amaranthus tricolor Linn. (Amaranthaceae) leafy vegetables from the Pune district, traditionally used as vermicides. Materials and Methods:The ethyl acetate, acetone and ethanol leaf extracts of both plants were subjected to preliminary investigations for thephytochemical elements. The anthelmintic activity of these extracts was tested against fully-grown Eisenia fetida earthworms.Ethyl acetate extract of A. viridis L. and acetone extract of Amaranthus tricolor L. showed the presence of all phytochemicals.Doses of 10–30 mg/ml were used in bioassay. Time of paralysis and death of earthworms was observed. Results: All extractsexhibited considerable dose-dependent activity against the reference drug, showing maximum activity at 30 mg/mL in bothplants. The most promising activity was exhibited by the ethyl acetate extract of the A. viridis L. (P (min.) = 4, D (min.) =5), followed by the acetone extract of the A. tricolor L. (P (min.) = 6, D (min.) = 13). Albendazole (20 mg/ml) and normalsaline were applied as a standard drug and control, respectively. High concentrations of alkaloids, tannins, and phenolicphytochemicals might be responsible for the exceptional activity. Conclusion: The present work scientifically validates thetraditional use and concludes that ethyl acetate and acetone extracts may be further processed to isolate the compoundsresponsible for said activity. One-way ANOVA with a significance level of 5% was used to validate the data (n = 3, p < 0.05).
{"title":"Investigation of Anthelmintic Potential of Two Leafy Vegetables from the Amaranthaceae Family","authors":"Manju Tripathi, V. B. Adsul, E. Khatiwora, M. P. Wadekar, S. A. Gaikwad","doi":"10.18311/jnr/2024/34714","DOIUrl":"https://doi.org/10.18311/jnr/2024/34714","url":null,"abstract":"Objective: The present study investigates the anthelmintic potential of Amaranthus viridis Linn. and Amaranthus tricolor Linn. (Amaranthaceae) leafy vegetables from the Pune district, traditionally used as vermicides. Materials and Methods:The ethyl acetate, acetone and ethanol leaf extracts of both plants were subjected to preliminary investigations for thephytochemical elements. The anthelmintic activity of these extracts was tested against fully-grown Eisenia fetida earthworms.Ethyl acetate extract of A. viridis L. and acetone extract of Amaranthus tricolor L. showed the presence of all phytochemicals.Doses of 10–30 mg/ml were used in bioassay. Time of paralysis and death of earthworms was observed. Results: All extractsexhibited considerable dose-dependent activity against the reference drug, showing maximum activity at 30 mg/mL in bothplants. The most promising activity was exhibited by the ethyl acetate extract of the A. viridis L. (P (min.) = 4, D (min.) =5), followed by the acetone extract of the A. tricolor L. (P (min.) = 6, D (min.) = 13). Albendazole (20 mg/ml) and normalsaline were applied as a standard drug and control, respectively. High concentrations of alkaloids, tannins, and phenolicphytochemicals might be responsible for the exceptional activity. Conclusion: The present work scientifically validates thetraditional use and concludes that ethyl acetate and acetone extracts may be further processed to isolate the compoundsresponsible for said activity. One-way ANOVA with a significance level of 5% was used to validate the data (n = 3, p < 0.05).","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"2 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deepak Yadav, P. Borkar, Bhushan Mhaiskar, Dhanashree Ravekar, Utkarsha Khaire
The Purpose of the Work: The elderly are prone to the condition known as Sandhigata vata (osteoarthritis). Some ofthe risk/cause factors include lifestyle choices, excessive weight, trauma, and a diet lacking in calcium. Vata is vitiated by Rooksha aahar (dry diet) and Ativyaam (excessive exercise) It mostly affects the body’s weight-bearing joints, particularlythe knee, hip, and lumbar spine. The most prevalent type of articular problems, Sandhigata vata (osteoarthritis) severelyrestricts a sufferer’s ability to walk, dress, bathe, and do other daily tasks. The condition frequently manifests as Shula (pain),Sotha (swelling), Vata Poornadriti Sparsha (crackling sound), and trouble flexing and extending the Sandhi (joints). calciumsupplements, and ultimately joint replacement are all alternatives for therapy. Methodology: A 39-year-old patient with Janu Sandhigata Vata (osteoarthritis) came to Mahatma Gandhi Ayurveda College, Hospital, and Research Centre, Salod (H),Wardha. Key Findings and Major Conclusion: This indoor patient received 10 days of Anuvasana with Murchhita Tila Taila(medicated oil) and Dhanwantri Tailam Basti (enema) and 10 days of Abhyanga (massage) at Nabhi (umbilicus), Parshva(flanks), Prushtha (back), and Ubhayapada pradesh. The patient reacted favourably to these Ayurvedic therapies and hadsignificant alleviation symptoms. The patient was treated with Anuvashana and Niruha basti (enema). Schedule for theperiod 08 February 2023 to 18 February 2023 days and substantial positive change in signs and symptoms was observed.
{"title":"A Clinical Case Study on Janu Sandhigata Vata with Dhanwantri Taila Basti","authors":"Deepak Yadav, P. Borkar, Bhushan Mhaiskar, Dhanashree Ravekar, Utkarsha Khaire","doi":"10.18311/jnr/2024/33727","DOIUrl":"https://doi.org/10.18311/jnr/2024/33727","url":null,"abstract":"The Purpose of the Work: The elderly are prone to the condition known as Sandhigata vata (osteoarthritis). Some ofthe risk/cause factors include lifestyle choices, excessive weight, trauma, and a diet lacking in calcium. Vata is vitiated by Rooksha aahar (dry diet) and Ativyaam (excessive exercise) It mostly affects the body’s weight-bearing joints, particularlythe knee, hip, and lumbar spine. The most prevalent type of articular problems, Sandhigata vata (osteoarthritis) severelyrestricts a sufferer’s ability to walk, dress, bathe, and do other daily tasks. The condition frequently manifests as Shula (pain),Sotha (swelling), Vata Poornadriti Sparsha (crackling sound), and trouble flexing and extending the Sandhi (joints). calciumsupplements, and ultimately joint replacement are all alternatives for therapy. Methodology: A 39-year-old patient with Janu Sandhigata Vata (osteoarthritis) came to Mahatma Gandhi Ayurveda College, Hospital, and Research Centre, Salod (H),Wardha. Key Findings and Major Conclusion: This indoor patient received 10 days of Anuvasana with Murchhita Tila Taila(medicated oil) and Dhanwantri Tailam Basti (enema) and 10 days of Abhyanga (massage) at Nabhi (umbilicus), Parshva(flanks), Prushtha (back), and Ubhayapada pradesh. The patient reacted favourably to these Ayurvedic therapies and hadsignificant alleviation symptoms. The patient was treated with Anuvashana and Niruha basti (enema). Schedule for theperiod 08 February 2023 to 18 February 2023 days and substantial positive change in signs and symptoms was observed.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Millions of people worldwide experience Urinary Tract Infections (UTIs), which rank among the most widespread bacterial infections. UTIs are a common health issue, particularly among women and certain populations. Escherichia coli is the most frequent pathogen, causing 75-90 % of UTIs. Timely diagnosis, appropriate treatment, and preventive measures can help reduce the burden of UTIs and minimize complications associated with these infections. In order to address this issue, classical formulations are mentioned in Ayurvedic texts. In the current study, hydroalcoholic extracts of Emblica officinalis (Amalaki) and Berberis aristata (Daruharidra) were prepared. The antimicrobial activity of the extracts and their combination was evaluated by establishing their Minimum Inhibitory Concentration (MIC) and measuring the zone of inhibition. The combination of Amalaki and Daruharidra with honey shows significant inhibition of E. coli which is comparable with tablet Norfloxacin. This study suggests that Emblica officinalis (Amalaki) and Berberis aristata (Daruharidra) can be used in Mutrakrichra associated with Mutradaha in the context of urinary tract infections.
{"title":"An In Vitro Study for Evaluating the Antimicrobial Efficacy of Polyherbal Combination Against Escherichia coli in the Management of Mutrakrichra (Urinary Tract Infection)","authors":"Thakral Vidhi, Karkare Manjusha, Bhagat Lumi, Mathad Prasanna, Patel Janki","doi":"10.18311/jnr/2024/34473","DOIUrl":"https://doi.org/10.18311/jnr/2024/34473","url":null,"abstract":"Millions of people worldwide experience Urinary Tract Infections (UTIs), which rank among the most widespread bacterial infections. UTIs are a common health issue, particularly among women and certain populations. Escherichia coli is the most frequent pathogen, causing 75-90 % of UTIs. Timely diagnosis, appropriate treatment, and preventive measures can help reduce the burden of UTIs and minimize complications associated with these infections. In order to address this issue, classical formulations are mentioned in Ayurvedic texts. In the current study, hydroalcoholic extracts of Emblica officinalis (Amalaki) and Berberis aristata (Daruharidra) were prepared. The antimicrobial activity of the extracts and their combination was evaluated by establishing their Minimum Inhibitory Concentration (MIC) and measuring the zone of inhibition. The combination of Amalaki and Daruharidra with honey shows significant inhibition of E. coli which is comparable with tablet Norfloxacin. This study suggests that Emblica officinalis (Amalaki) and Berberis aristata (Daruharidra) can be used in Mutrakrichra associated with Mutradaha in the context of urinary tract infections.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"64 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Deep Prakash, Atul Vitthal Patil, Sanjay Chandrakant Babar
Ayurvedic lifestyle is the need of today’s era. Every doctor’s top priority is to treat a patient’s illness and determine his current state of health. Bhaganadara can be correlated with Fistula in Ano, which is considered difficult to treat because of its callus nature and high recurrence rate. ‘Bhagandara’ is the name of the disease in which Bhaga, Guda, and Basti Pradesha get Vidaarita (become torn). Fistula in Ano’s defining characteristic is recurring discharge with one or more exterior openings. Ayurveda has mentioned various treatment modalities for Bhagandara (Fistula in Ano) which include Kshara Sutra treatment, Bheshaja Chikitsa, Shastra Karma, application of Lepa, etc. All treatments help to heal the disease fast. Jatipatradi lepa is mentioned in the Bhaishajaya Ratnawali for the management of Bhagandara (Fistula in Ano). In this case study, Jatipatradi Lepa is used in the management of Bhagandara (Fistula in Ano).
{"title":"Case Study of Bhagandara in Ayurveda With Special Reference to Fistula in Ano","authors":"Deep Prakash, Atul Vitthal Patil, Sanjay Chandrakant Babar","doi":"10.18311/jnr/2024/33838","DOIUrl":"https://doi.org/10.18311/jnr/2024/33838","url":null,"abstract":"Ayurvedic lifestyle is the need of today’s era. Every doctor’s top priority is to treat a patient’s illness and determine his current state of health. Bhaganadara can be correlated with Fistula in Ano, which is considered difficult to treat because of its callus nature and high recurrence rate. ‘Bhagandara’ is the name of the disease in which Bhaga, Guda, and Basti Pradesha get Vidaarita (become torn). Fistula in Ano’s defining characteristic is recurring discharge with one or more exterior openings. Ayurveda has mentioned various treatment modalities for Bhagandara (Fistula in Ano) which include Kshara Sutra treatment, Bheshaja Chikitsa, Shastra Karma, application of Lepa, etc. All treatments help to heal the disease fast. Jatipatradi lepa is mentioned in the Bhaishajaya Ratnawali for the management of Bhagandara (Fistula in Ano). In this case study, Jatipatradi Lepa is used in the management of Bhagandara (Fistula in Ano).","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"72 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139395038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Kalaiarasi, R. Keerthika, D. Periyasami, N. J. Muthukumar
A 48 year old female staff nurse from Chennai consulted in the Varma Maruthuvam Outpatient Department of APH-NIS, Chennai presented with complaints of sudden and severe stabbing pain with burning sensation at the left half of the maxillary and mandibular region for one year. After her MRI scan was done, she was diagnosed with trigeminal neuralgia due to vascular compression. The patient had consulted an allopathic hospital and used carbamazepine for the long term. She experienced some temporary relief, but the episodes occurred for a short while, and she felt drowsy. For further improvement, she came for Varmam treatment. The present study is a case report of typical Trigeminal Neuralgia (TN) that was treated with Siddha Varmam therapy along with Amukkarachooranam, Arumugachenduram and Arakku thailam for two months. This case report showed a promising reduction in pain episodes and recurrence following treatment, as measured by the Visual Analogue Scale (VAS) score. This study sheds light on the fact that Varmam therapy with concomitant medicines has a promising effect in the management of trigeminal neuralgia.
{"title":"Trigeminal Neuralgia Management with Varmam Therapy and Siddha Medicine – A Case Report","authors":"C. Kalaiarasi, R. Keerthika, D. Periyasami, N. J. Muthukumar","doi":"10.18311/jnr/2024/34144","DOIUrl":"https://doi.org/10.18311/jnr/2024/34144","url":null,"abstract":"A 48 year old female staff nurse from Chennai consulted in the Varma Maruthuvam Outpatient Department of APH-NIS, Chennai presented with complaints of sudden and severe stabbing pain with burning sensation at the left half of the maxillary and mandibular region for one year. After her MRI scan was done, she was diagnosed with trigeminal neuralgia due to vascular compression. The patient had consulted an allopathic hospital and used carbamazepine for the long term. She experienced some temporary relief, but the episodes occurred for a short while, and she felt drowsy. For further improvement, she came for Varmam treatment. The present study is a case report of typical Trigeminal Neuralgia (TN) that was treated with Siddha Varmam therapy along with Amukkarachooranam, Arumugachenduram and Arakku thailam for two months. This case report showed a promising reduction in pain episodes and recurrence following treatment, as measured by the Visual Analogue Scale (VAS) score. This study sheds light on the fact that Varmam therapy with concomitant medicines has a promising effect in the management of trigeminal neuralgia.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"32 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruchi Sharma, C. Majee, R. Mazumder, Avijit Mazumder, Pankaj Kumar Tyagi, M. V. N. L. Chaitanya
Throughout the biliary tree, a variety of cells give rise to cholangiocarcinomas, a broad group of malignancies. The fact that these tumours are silent and asymptomatic, especially in their early stages, seriously impairs the effectiveness of available therapeutic options and contributes to their poor prognosis. Over the past few years, increased efforts have been made to identify the aetiology and signalling pathways of these tumours and to create more potent therapies. Since alkaloids are more potent and effective against cholangiocarcinoma cell lines, they have gained importance in the treatment of cholangiocarcinoma. In cell lines with cholangiocarcinoma, they promote apoptosis. and restrict the spread of cells, departure, and development. This review highlights the recent developments in the study of CCA, primarily concentrating on the regulation of the signalling pathway and revealing alkaloids demonstrating strong anti-cholangiocarcinoma efficacy, providing researchers with a rapid approach for the future development of powerful and efficient pharmaceutical compounds.
在整个胆道树中，各种细胞会产生胆管癌这一广泛的恶性肿瘤。这些肿瘤无声无症状，尤其是在早期阶段，这严重影响了现有治疗方案的有效性，并导致其预后不良。过去几年来，人们一直在努力查明这些肿瘤的病因和信号通路，并开发出更有效的疗法。由于生物碱对胆管癌细胞株的作用更强、更有效，因此在治疗胆管癌方面具有重要意义。在胆管癌细胞株中，生物碱能促进细胞凋亡，限制细胞扩散、离体和发展。本综述重点介绍了 CCA 研究的最新进展，主要集中在信号通路的调控方面，并揭示了具有强大抗胆管癌功效的生物碱，为研究人员今后开发强效、高效的药物化合物提供了快速途径。
{"title":"Insight Into the Role of Alkaloids in the Different Signalling Pathways of Cholangiocarcinoma","authors":"Ruchi Sharma, C. Majee, R. Mazumder, Avijit Mazumder, Pankaj Kumar Tyagi, M. V. N. L. Chaitanya","doi":"10.18311/jnr/2024/34661","DOIUrl":"https://doi.org/10.18311/jnr/2024/34661","url":null,"abstract":"Throughout the biliary tree, a variety of cells give rise to cholangiocarcinomas, a broad group of malignancies. The fact that these tumours are silent and asymptomatic, especially in their early stages, seriously impairs the effectiveness of available therapeutic options and contributes to their poor prognosis. Over the past few years, increased efforts have been made to identify the aetiology and signalling pathways of these tumours and to create more potent therapies. Since alkaloids are more potent and effective against cholangiocarcinoma cell lines, they have gained importance in the treatment of cholangiocarcinoma. In cell lines with cholangiocarcinoma, they promote apoptosis. and restrict the spread of cells, departure, and development. This review highlights the recent developments in the study of CCA, primarily concentrating on the regulation of the signalling pathway and revealing alkaloids demonstrating strong anti-cholangiocarcinoma efficacy, providing researchers with a rapid approach for the future development of powerful and efficient pharmaceutical compounds.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"58 26","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Giramkar, Sarika Mane, Abhilasha Dolle, Jyoti Shirodkar, Supriya Bhalerao
Barley (Hordeum vulgare L.) is a cereal rich in soluble dietary fibres, and antioxidant and bioactive compounds. Ayurveda reported its use as a therapeutic food. Being a rich source of functional ingredients, it has the potential to be incorporated for nutritional enrichment. Still, there are certain limitations to its use. The present study first time analyses the effect of different processing methods recommended in Ayurveda on variation in its composition and permeability. The hulled barley was processed namely dry roasting, roasting with cow ghee and roasting after overnight soaking in Triphala decoction. Further evaluated for proximate composition, in vitro anti-glycation and permeability of soluble fibres. A variation in proximate composition was seen in all processed forms. Soluble fibre content was maximum in hulled barley. The β-glucan of hulled barley was 39.41 mg/g, which was increased up to 62.22 mg/g in dry roasted barley. All processed forms exhibited inhibition of glycation, which was maximum with Triphala-soaked barley. Processing improved the permeability of soluble fibres, which was maximum with dry roasted form (54%). Dry-roasted barley showed improvement in almost all analyzed parameters. Hence, it can be explored further to facilitate the use of barley as a dietary supplement.
{"title":"Effect of Different Processing Methods on Composition, Biological Activities and Permeability of Barley (Hordeum vulgare L.): An Indigenous Cereal","authors":"S. Giramkar, Sarika Mane, Abhilasha Dolle, Jyoti Shirodkar, Supriya Bhalerao","doi":"10.18311/jnr/2024/32417","DOIUrl":"https://doi.org/10.18311/jnr/2024/32417","url":null,"abstract":"Barley (Hordeum vulgare L.) is a cereal rich in soluble dietary fibres, and antioxidant and bioactive compounds. Ayurveda reported its use as a therapeutic food. Being a rich source of functional ingredients, it has the potential to be incorporated for nutritional enrichment. Still, there are certain limitations to its use. The present study first time analyses the effect of different processing methods recommended in Ayurveda on variation in its composition and permeability. The hulled barley was processed namely dry roasting, roasting with cow ghee and roasting after overnight soaking in Triphala decoction. Further evaluated for proximate composition, in vitro anti-glycation and permeability of soluble fibres. A variation in proximate composition was seen in all processed forms. Soluble fibre content was maximum in hulled barley. The β-glucan of hulled barley was 39.41 mg/g, which was increased up to 62.22 mg/g in dry roasted barley. All processed forms exhibited inhibition of glycation, which was maximum with Triphala-soaked barley. Processing improved the permeability of soluble fibres, which was maximum with dry roasted form (54%). Dry-roasted barley showed improvement in almost all analyzed parameters. Hence, it can be explored further to facilitate the use of barley as a dietary supplement.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"53 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139396046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plants have been the primary source of medications and are essential to maintaining human health. Despite significant advancements in the field of synthetic medications and antibiotics, plants continue to be essential in both traditional and modern medicine all over the world. It significantly increases soil fertility and has a variety of characteristics that make it an ideal founder restoration species. There has not been any evidence of an Sonneratia apetala natural invasion in the northern mangrove region yet. This tree is an evergreen species that is known for its rapid growth and natural occurrence. The main phyto-constituents present in Sonneratia apetala are betulinic acid, lupeone, lupeol, stigmast-5-ene 3beta, β-amyrin hexadecaneate, 5β-cholestane-3α,7α-diol, and physcoion. Some chemical constituents present in Sonneratia apetala are gibberellin, quercetin, caffeic acid, (-) catechin, and epicatechin. The fruits and bark have antioxidant, antidiabetic activity, antibacterial, hepatoprotective effect and astringent activity, anticancer activity, hypouricemic activity, and gastroprotective effects. The constituents of bark and leaf include flavonoids, alkaloids, tannins, glycosides (anthraquinone and cardiac), terpenoids, saponins, steroids, protein and amino acids, steroid and gums, carbohydrates, vitamins (thiamine, riboflavin) and certain minerals. This review also reported its ecological-, salt regulatory- and reproductive- features as well.
{"title":"<i>Sonneratia apetala</i>: Its Ecology, Bioactive Compounds and Biological Activities Including its Nano-formulations","authors":"Sankhadip Bose, Sujayita Mazumder, Somsubhra Ghosh, Sabyasachi Banerjee, Swarnali Roy, Nardev Singh","doi":"10.18311/jnr/2023/34073","DOIUrl":"https://doi.org/10.18311/jnr/2023/34073","url":null,"abstract":"Plants have been the primary source of medications and are essential to maintaining human health. Despite significant advancements in the field of synthetic medications and antibiotics, plants continue to be essential in both traditional and modern medicine all over the world. It significantly increases soil fertility and has a variety of characteristics that make it an ideal founder restoration species. There has not been any evidence of an Sonneratia apetala natural invasion in the northern mangrove region yet. This tree is an evergreen species that is known for its rapid growth and natural occurrence. The main phyto-constituents present in Sonneratia apetala are betulinic acid, lupeone, lupeol, stigmast-5-ene 3beta, β-amyrin hexadecaneate, 5β-cholestane-3α,7α-diol, and physcoion. Some chemical constituents present in Sonneratia apetala are gibberellin, quercetin, caffeic acid, (-) catechin, and epicatechin. The fruits and bark have antioxidant, antidiabetic activity, antibacterial, hepatoprotective effect and astringent activity, anticancer activity, hypouricemic activity, and gastroprotective effects. The constituents of bark and leaf include flavonoids, alkaloids, tannins, glycosides (anthraquinone and cardiac), terpenoids, saponins, steroids, protein and amino acids, steroid and gums, carbohydrates, vitamins (thiamine, riboflavin) and certain minerals. This review also reported its ecological-, salt regulatory- and reproductive- features as well.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" 8","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135191736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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