A. Porwal, Gopal Kundu, G. Bhagwat, R. Nimma, Jayeeta Chowdhury
Anorectal problems such as anal fistula, Crohn’s disease, haemorrhoids, and fissures are prevalent across the general population. Severe discomfort, inflammation, swelling, itching, and bleeding during defecation are common symptoms of anorectal disorders. Depending on the severity of the condition, several medical therapies or surgical procedures may be used to treat these diseases. Surgical treatments like fistulectomy and sphincterotomy or haemorrhoidectomy are highly intrusive and have a risk of recurrence. Furthermore, surgical procedures cause pain, inflammation, and perineal sores. These will lead to severe socio-economic ramifications in the patient’s life. Therefore, treatment options that aid in the reduction of inflammation, pain, and perineal wounds are critical for anorectal disease management. Herbal formulations that comprise turmeric (Curcuma longa) extract have anti-inflammatory, pain-relieving, and wound-healing properties. The purpose of the current study was to elucidate the effect of Turmocin Plus on the infiltration of inflammatory cells and the expression of pro-angiogenic factors in anorectal and lower gastrointestinal disorders. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and wound migration assays were performed to determine the results of Turmocin Plus on the viability and migration of inflammatory cells. The effect of Turmocin Plus on pro-angiogenic factors was determined using Western blot analysis and immunofluorescence. Further, we validate our in vitro findings in human fistula specimens using IHC. The investigation showed that Turmocin Plus inhibits immunological (RAW 264.7) cell migration while maintaining their viability. Inflammation and increased levels of Vascular Endothelial Growth Factor (VEGF) were observed in Inflammatory Bowel Disease (IBD), fistula, fissures, and higher-grade haemorrhoids. However, Turmocin Plus suppresses the VEGF expression in macrophages (RAW 264.7) cells. Furthermore, compared to untreated human fistula tissues, decreased expression of VEGF was observed in Turmocin Plus treated patient samples, validating the in vitro findings. Our study suggests that Turmocin Plus is a potent therapeutic formulation in treating fistula, perineal wounds, and Crohn’s disease.
肛瘘、克罗恩病、痔疮和肛裂等肛门直肠问题在普通人群中普遍存在。排便时严重不适、发炎、肿胀、瘙痒和出血是肛门直肠疾病的常见症状。根据病情的严重程度，可采用多种药物疗法或外科手术来治疗这些疾病。肛瘘切除术、括约肌切开术或痔切除术等手术疗法具有很强的侵入性，而且有复发的风险。此外，手术治疗还会引起疼痛、炎症和会阴部溃疡。这些都会给患者的生活带来严重的社会经济影响。因此，有助于减轻炎症、疼痛和会阴伤口的治疗方案对于肛门直肠疾病的治疗至关重要。由姜黄（Curcuma longa）提取物组成的草药配方具有抗炎、止痛和伤口愈合的特性。本研究旨在阐明 Turmocin Plus 对肛门直肠和下消化道疾病中炎性细胞浸润和促血管生成因子表达的影响。通过 MTT（3-[4,5-二甲基噻唑-2-基]-2,5-二苯基四唑溴化物）和伤口迁移试验来确定 Turmocin Plus 对炎性细胞活力和迁移的影响。通过 Western 印迹分析和免疫荧光测定了 Turmocin Plus 对促血管生成因子的影响。此外，我们还在人体瘘管标本中使用 IHC 验证了我们的体外研究结果。调查显示，Turmocin Plus 可抑制免疫细胞（RAW 264.7）迁移，同时保持其活力。在炎症性肠病（IBD）、瘘管、肛裂和高位痔疮中观察到了炎症和血管内皮生长因子（VEGF）水平的升高。然而，Turmocin Plus 能抑制巨噬细胞（RAW 264.7）中血管内皮生长因子的表达。此外，与未经处理的人体瘘管组织相比，Turmocin Plus 处理过的患者样本中血管内皮生长因子的表达有所下降，这验证了体外研究结果。我们的研究表明，Turmocin Plus 是一种治疗瘘管、会阴伤口和克罗恩病的有效制剂。
{"title":"Turmocin Plus Suppresses Vascular Endothelial Growth Factor (VEGF) and Macrophage Infiltration in the Management of Perineal Wounds, Anal Fistula, Acute Anal Fissures and Haemorrhoids","authors":"A. Porwal, Gopal Kundu, G. Bhagwat, R. Nimma, Jayeeta Chowdhury","doi":"10.18311/jnr/2024/33298","DOIUrl":"https://doi.org/10.18311/jnr/2024/33298","url":null,"abstract":"Anorectal problems such as anal fistula, Crohn’s disease, haemorrhoids, and fissures are prevalent across the general population. Severe discomfort, inflammation, swelling, itching, and bleeding during defecation are common symptoms of anorectal disorders. Depending on the severity of the condition, several medical therapies or surgical procedures may be used to treat these diseases. Surgical treatments like fistulectomy and sphincterotomy or haemorrhoidectomy are highly intrusive and have a risk of recurrence. Furthermore, surgical procedures cause pain, inflammation, and perineal sores. These will lead to severe socio-economic ramifications in the patient’s life. Therefore, treatment options that aid in the reduction of inflammation, pain, and perineal wounds are critical for anorectal disease management. Herbal formulations that comprise turmeric (Curcuma longa) extract have anti-inflammatory, pain-relieving, and wound-healing properties. The purpose of the current study was to elucidate the effect of Turmocin Plus on the infiltration of inflammatory cells and the expression of pro-angiogenic factors in anorectal and lower gastrointestinal disorders. MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and wound migration assays were performed to determine the results of Turmocin Plus on the viability and migration of inflammatory cells. The effect of Turmocin Plus on pro-angiogenic factors was determined using Western blot analysis and immunofluorescence. Further, we validate our in vitro findings in human fistula specimens using IHC. The investigation showed that Turmocin Plus inhibits immunological (RAW 264.7) cell migration while maintaining their viability. Inflammation and increased levels of Vascular Endothelial Growth Factor (VEGF) were observed in Inflammatory Bowel Disease (IBD), fistula, fissures, and higher-grade haemorrhoids. However, Turmocin Plus suppresses the VEGF expression in macrophages (RAW 264.7) cells. Furthermore, compared to untreated human fistula tissues, decreased expression of VEGF was observed in Turmocin Plus treated patient samples, validating the in vitro findings. Our study suggests that Turmocin Plus is a potent therapeutic formulation in treating fistula, perineal wounds, and Crohn’s disease.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"64 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139872872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this overview, information on the chemistry, sources, contents, and pharmacological properties of two flavones, namely, tricetin (TCT) and tricin (TC), is updated. TCT occurs mainly in honey and pollen of plant species belonging to the genus Eucalyptus of the family Myrtaceae. TC is found in monocotyledon species of the family Poaceae, occurring mainly in cereal crops such as oats, barley, rice, wheat, and corn, and in bamboo species. The chemical structure of TCT contains two hydroxyl (OH) groups at C5 and C7 of ring A and three OH groups at C3’, C4’, and C5’ of ring B, with no methoxy (OCH3) groups. TC has two OH groups at C5 and C7 of ring A, two OCH3 groups at C3’ and C5’, and one OH group at C4’ of ring B, i.e., at both sides of the C4’ OH group. This renders greater bioavailability, higher metabolic stability, and better intestinal absorption to TC than TCT. In this overview, TCT and TC have eight and seven studies on anti-cancer properties, and 14 and 31 studies on other pharmacological properties, respectively. Both flavones are equally strong in terms of cytotoxicity towards cancer cells. With greater bioavailability, higher metabolic stability, and better intestinal absorption, the other pharmacological properties of TC are stronger than TCT, but not for anti-cancer properties.
{"title":"Tricetin and Tricin: An Overview of the Chemistry, Sources, Contents, and Pharmacological Properties of these Flavones","authors":"Eric Wei Chiang Chan","doi":"10.18311/jnr/2024/33085","DOIUrl":"https://doi.org/10.18311/jnr/2024/33085","url":null,"abstract":"In this overview, information on the chemistry, sources, contents, and pharmacological properties of two flavones, namely, tricetin (TCT) and tricin (TC), is updated. TCT occurs mainly in honey and pollen of plant species belonging to the genus Eucalyptus of the family Myrtaceae. TC is found in monocotyledon species of the family Poaceae, occurring mainly in cereal crops such as oats, barley, rice, wheat, and corn, and in bamboo species. The chemical structure of TCT contains two hydroxyl (OH) groups at C5 and C7 of ring A and three OH groups at C3’, C4’, and C5’ of ring B, with no methoxy (OCH3) groups. TC has two OH groups at C5 and C7 of ring A, two OCH3 groups at C3’ and C5’, and one OH group at C4’ of ring B, i.e., at both sides of the C4’ OH group. This renders greater bioavailability, higher metabolic stability, and better intestinal absorption to TC than TCT. In this overview, TCT and TC have eight and seven studies on anti-cancer properties, and 14 and 31 studies on other pharmacological properties, respectively. Both flavones are equally strong in terms of cytotoxicity towards cancer cells. With greater bioavailability, higher metabolic stability, and better intestinal absorption, the other pharmacological properties of TC are stronger than TCT, but not for anti-cancer properties.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"39 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139880772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The purpose of the research work was the extraction and isolation of Ursolic Acid (URA) from the leaves of Nerium oleander (N. oleander) and the assessment of its anti-inflammatory activity using an in-vitro model. Methods: Ursolic Acid (URA) is a bioactive molecule. It is a key component of N. oleander. The hydroalcoholic maceration method was used for extract preparation and was used to isolate the bioactive components of URA. The prepared extract, isolated URA were characterize and analyse by using pharmacognostic parameters, Fourier Transform Infrared (FTIR) and Thin Layer Chromatography (TLC) method. The carrageenan-induced inflammation rat paw oedema test in-vitro model was used for the assessment of anti-inflammatory properties of isolated bioactive compound URA. Results: The results of evaluation and characterization indicated that the extract’s ash value and extractive values were within the parameters specified in the Indian Ayurvedic Pharmacopoeia. The prepared hydroalcohalic extract has potential bioactive components such as flavonoids, saponins, and triterpinoids. The isolated compound was URA. The extract may be able to alleviate inflammation, according to the percentage inhibition. Conclusion: The URA was successfully removed from the leaves of N. oleander. The examination criteria revealed that the extract contained certain small contaminants, which may have anti-inflammatory effects.
目的：研究工作的目的是从夹竹桃叶中提取和分离熊果酸（URA），并利用体外模型评估其抗炎活性：方法：熊果酸（URA）是一种生物活性分子。方法：熊果酸（URA）是一种生物活性分子，是夹竹桃的主要成分。采用水醇浸泡法制备提取物，并分离出 URA 的生物活性成分。利用药理学参数、傅立叶变换红外光谱（FTIR）和薄层色谱法（TLC）对制备的提取物和分离的 URA 进行了表征和分析。使用卡拉胶诱导的炎症大鼠爪水肿体外模型来评估分离的生物活性化合物 URA 的抗炎特性：评估和表征结果表明，提取物的灰分值和萃取值均符合印度阿育吠陀药典规定的参数。所制备的水合提取物具有潜在的生物活性成分，如类黄酮、皂苷和三萜类化合物。分离出的化合物是 URA。根据抑制百分比，该提取物可以缓解炎症。结论成功地从夹竹桃叶中提取了 URA。检查标准显示，提取物中含有某些可能具有抗炎作用的小杂质。
{"title":"Isolation, Formulation and Assessment of Anti-inflammatory Properties of Ursolic Acid from Nerium oleander","authors":"Ajay Kumar Shukla, Manish Kumar Yadav, Komal Sharma","doi":"10.18311/jnr/2024/33540","DOIUrl":"https://doi.org/10.18311/jnr/2024/33540","url":null,"abstract":"Purpose: The purpose of the research work was the extraction and isolation of Ursolic Acid (URA) from the leaves of Nerium oleander (N. oleander) and the assessment of its anti-inflammatory activity using an in-vitro model.\u0000Methods: Ursolic Acid (URA) is a bioactive molecule. It is a key component of N. oleander. The hydroalcoholic maceration method was used for extract preparation and was used to isolate the bioactive components of URA. The prepared extract, isolated URA were characterize and analyse by using pharmacognostic parameters, Fourier Transform Infrared (FTIR) and Thin Layer Chromatography (TLC) method. The carrageenan-induced inflammation rat paw oedema test in-vitro model was used for the assessment of anti-inflammatory properties of isolated bioactive compound URA.\u0000Results: The results of evaluation and characterization indicated that the extract’s ash value and extractive values were within the parameters specified in the Indian Ayurvedic Pharmacopoeia. The prepared hydroalcohalic extract has potential bioactive components such as flavonoids, saponins, and triterpinoids. The isolated compound was URA. The extract may be able to alleviate inflammation, according to the percentage inhibition. Conclusion: The URA was successfully removed from the leaves of N. oleander. The examination criteria revealed that the extract contained certain small contaminants, which may have anti-inflammatory effects.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139884848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Piyush Chaudhary, B. Rathi, N. Lamba, Anil Sharma, Renu Rathi
Drug standardisation, profiling, and quality control continue to be a challenge for Ayurvedic medicines due to their wide range of dosage forms. Different dosage forms like decoctions and powders result in non-compliance from the patient owing to their palatability or cumbersome methods of administration. The present study aims to pharmaceutically process a traditional decoction, Phalatrikadi Kwatha, and standardise it into tablet form, known as Phalatrikadi Ghana Vati (PGV). PGV was prepared and subjected to organoleptic, physicochemical, phytochemical analysis, and HPTLC analysis in an attempt to define its quality parameters and standardisation. Distinct fingerprints of Phalatrikadi Ghana Vati were obtained. Out of the eight components identified, the components with Rf values 0.08, 0.74, 0.65 and 0.83 were more predominant with more percent areas 9.65%, 14.91%, 18.02%, and 40.67%, respectively Quantitative physicochemical analysis revealed loss on drying as 1.33%, ash value as 4.53%, water-soluble extractive as 15.38%, alcohol extractive as 9.63% and pH as 5.1. The study also revealed the presence of alkaloids, glycosides, flavonoids, amino acids, and saponins. Preliminary profiling of PGV exhibited striking analytical characteristics. The physicochemical parameters were in the range of a standard tablet. The quantitative physicochemical parameters and HPTLC profile can be used as a reference standard for the quality control of Phalatrikadi Ghan Vati.
{"title":"Standardisation and Quality Control Parameters of Phalatrikadi Ghana Vati – An Ayurvedic Formulation","authors":"Piyush Chaudhary, B. Rathi, N. Lamba, Anil Sharma, Renu Rathi","doi":"10.18311/jnr/2024/35126","DOIUrl":"https://doi.org/10.18311/jnr/2024/35126","url":null,"abstract":"Drug standardisation, profiling, and quality control continue to be a challenge for Ayurvedic medicines due to their wide range of dosage forms. Different dosage forms like decoctions and powders result in non-compliance from the patient owing to their palatability or cumbersome methods of administration. The present study aims to pharmaceutically process a traditional decoction, Phalatrikadi Kwatha, and standardise it into tablet form, known as Phalatrikadi Ghana Vati (PGV). PGV was prepared and subjected to organoleptic, physicochemical, phytochemical analysis, and HPTLC analysis in an attempt to define its quality parameters and standardisation. Distinct fingerprints of Phalatrikadi Ghana Vati were obtained. Out of the eight components identified, the components with Rf values 0.08, 0.74, 0.65 and 0.83 were more predominant with more percent areas 9.65%, 14.91%, 18.02%, and 40.67%, respectively Quantitative physicochemical analysis revealed loss on drying as 1.33%, ash value as 4.53%, water-soluble extractive as 15.38%, alcohol extractive as 9.63% and pH as 5.1. The study also revealed the presence of alkaloids, glycosides, flavonoids, amino acids, and saponins. Preliminary profiling of PGV exhibited striking analytical characteristics. The physicochemical parameters were in the range of a standard tablet. The quantitative physicochemical parameters and HPTLC profile can be used as a reference standard for the quality control of Phalatrikadi Ghan Vati.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139886085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Oppong Bekoe, Emmanuel Orman, Michael Lartey, Andrew Gordon, Tonny Asafo-Agyei
Polyalthia longifolia (Sonn.) is a medicinal plant that belongs to the family Annonaceae, and it is distributed in the tropics. This plant is widely grown in West Africa for its ornamental and medicinal purposes. There are two varieties of P. longifolia which are commonly distinguishable by the direction of their branches. One has spreading perpendicular branches, and the other has drooping pendulous branches. Traditional herbal practitioners believe that one variety (P. longifolia cv. pendula) is more medicinal than the other. This study, therefore, sought to investigate the phytochemical components of the two varieties of P. longifolia by HPTLC, UPLC, and elemental analysis by ICP-EOS. No observable differences were found in the phytochemical and elemental profiles of these varieties that could help distinguish one from the other or could account for its supposed differences in medicinal properties. A total of 22 elements were detected in the samples of the two varieties of the plant. Qualitatively, the elemental content of both varieties was similar. Only Iridium was not detected in all samples. Heavy metals including As, Pb, Cd, and Hg had their levels above the recommended limits.
{"title":"Phytochemical Analysis and Elemental Contents of Varieties of Polyalthia longifolia (Sonn.) Thwaites","authors":"E. Oppong Bekoe, Emmanuel Orman, Michael Lartey, Andrew Gordon, Tonny Asafo-Agyei","doi":"10.18311/jnr/2024/32921","DOIUrl":"https://doi.org/10.18311/jnr/2024/32921","url":null,"abstract":"Polyalthia longifolia (Sonn.) is a medicinal plant that belongs to the family Annonaceae, and it is distributed in the tropics. This plant is widely grown in West Africa for its ornamental and medicinal purposes. There are two varieties of P. longifolia which are commonly distinguishable by the direction of their branches. One has spreading perpendicular branches, and the other has drooping pendulous branches. Traditional herbal practitioners believe that one variety (P. longifolia cv. pendula) is more medicinal than the other. This study, therefore, sought to investigate the phytochemical components of the two varieties of P. longifolia by HPTLC, UPLC, and elemental analysis by ICP-EOS. No observable differences were found in the phytochemical and elemental profiles of these varieties that could help distinguish one from the other or could account for its supposed differences in medicinal properties. A total of 22 elements were detected in the samples of the two varieties of the plant. Qualitatively, the elemental content of both varieties was similar. Only Iridium was not detected in all samples. Heavy metals including As, Pb, Cd, and Hg had their levels above the recommended limits.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"96 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139822061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gayatri R. Nayak, Amrita Parida, Shreya Hegde, Smita Shenoy, K. G. Mohandas Rao, K. Shivakumar Reddy, V. Manju
In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.
{"title":"Sinapis alba ln Status Epilepticus: A Preclinical Study","authors":"Gayatri R. Nayak, Amrita Parida, Shreya Hegde, Smita Shenoy, K. G. Mohandas Rao, K. Shivakumar Reddy, V. Manju","doi":"10.18311/jnr/2024/34983","DOIUrl":"https://doi.org/10.18311/jnr/2024/34983","url":null,"abstract":"In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"120 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139827833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
G. S. Taki, Indrajit Sarkar, Rakhi Saha, A. K. Mallick
The traditional herbal remedy utilises the active principles of medicinal plants, either in singular or combination. Electro-homoeopathy uses the favourable component of the active principle or medicinal properties, removing the toxic part, and using various scientific processes to prepare the remedies. To achieve faster recovery of the affected organ, Count Cesar Mattei invented a Complex herbal remedy by the Synergic mixing of the Spagyric essence of selected plants. Mattei also mentioned that a suitable complex remedy could fully cover and control the complex remedy and the affected organ. In such a complex, the toxin is eliminated by thermal, various energy-driven scientific processes, enhancing medicinal properties. A table has been designed for 114 plants to correlate the active principles/medicinal properties of the parts used in various Electro-Homeopathy remedies. The uses of the complex remedy and the remarkable clinical results obtained by the inventor and his numerous followers have been referred to in their books and reports. The basic steps of the selection of remedies in the context of affected organs and diseases are presented in the tables. The underlying Alchemical Spagyric preparation method Cohobation has been precisely addressed here.
{"title":"Synergic Active Principles of Medicinal Plants in Complex Remedy Makes Electro-Homeopathy — A Novel Medical System","authors":"G. S. Taki, Indrajit Sarkar, Rakhi Saha, A. K. Mallick","doi":"10.18311/jnr/2024/34963","DOIUrl":"https://doi.org/10.18311/jnr/2024/34963","url":null,"abstract":"The traditional herbal remedy utilises the active principles of medicinal plants, either in singular or combination. Electro-homoeopathy uses the favourable component of the active principle or medicinal properties, removing the toxic part, and using various scientific processes to prepare the remedies. To achieve faster recovery of the affected organ, Count Cesar Mattei invented a Complex herbal remedy by the Synergic mixing of the Spagyric essence of selected plants. Mattei also mentioned that a suitable complex remedy could fully cover and control the complex remedy and the affected organ. In such a complex, the toxin is eliminated by thermal, various energy-driven scientific processes, enhancing medicinal properties. A table has been designed for 114 plants to correlate the active principles/medicinal properties of the parts used in various Electro-Homeopathy remedies. The uses of the complex remedy and the remarkable clinical results obtained by the inventor and his numerous followers have been referred to in their books and reports. The basic steps of the selection of remedies in the context of affected organs and diseases are presented in the tables. The underlying Alchemical Spagyric preparation method Cohobation has been precisely addressed here.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"223 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139830881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Since ancient times, medicinal plants have been the primary source of most medications. In actuality, a large number of the medications that are now on the market may be obtained either directly in extract form or in modified synthetic form. As phytoconstituents, which are employed by plants to carry out biological processes and defend us from predators like viruses, fungi, and other microbes, they are naturally able to produce goods that are helpful for humans. Hernandia nymphaeifolia is a traditional medicinal plant that is used in several traditional remedies to treat several ailments. The extracts from various portions of the plant have excellent therapeutic effectiveness. Numerous pharmacological investigations have demonstrated this plant’s capacity to display anti-cytotoxic, anti-inflammatory, anti-platelet aggregation, vasodilator, antioxidant, anti-microbial, and Ca2+ signalling properties. The current study covers a thorough examination of the plant’s systematic botanical position, phytochemical analysis, investigations into the plant’s pharmacological activity, and therapeutic uses.
{"title":"A Review of the Phytochemical and Pharmacological Characteristics of Hernandia nymphaeifolia","authors":"Sumana Das, Afsana Khan, Amlan Bishal, Bratati Badyopadhya, Mohini Mondal, Aveek Datta, Shilpy Jha, Raneet Das, Biplab Debnath","doi":"10.18311/jnr/2024/34770","DOIUrl":"https://doi.org/10.18311/jnr/2024/34770","url":null,"abstract":"Since ancient times, medicinal plants have been the primary source of most medications. In actuality, a large number of the medications that are now on the market may be obtained either directly in extract form or in modified synthetic form. As phytoconstituents, which are employed by plants to carry out biological processes and defend us from predators like viruses, fungi, and other microbes, they are naturally able to produce goods that are helpful for humans. Hernandia nymphaeifolia is a traditional medicinal plant that is used in several traditional remedies to treat several ailments. The extracts from various portions of the plant have excellent therapeutic effectiveness. Numerous pharmacological investigations have demonstrated this plant’s capacity to display anti-cytotoxic, anti-inflammatory, anti-platelet aggregation, vasodilator, antioxidant, anti-microbial, and Ca2+ signalling properties. The current study covers a thorough examination of the plant’s systematic botanical position, phytochemical analysis, investigations into the plant’s pharmacological activity, and therapeutic uses.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"30 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139882670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gayatri R. Nayak, Amrita Parida, Shreya Hegde, Smita Shenoy, K. G. Mohandas Rao, K. Shivakumar Reddy, V. Manju
In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.
{"title":"Sinapis alba ln Status Epilepticus: A Preclinical Study","authors":"Gayatri R. Nayak, Amrita Parida, Shreya Hegde, Smita Shenoy, K. G. Mohandas Rao, K. Shivakumar Reddy, V. Manju","doi":"10.18311/jnr/2024/34983","DOIUrl":"https://doi.org/10.18311/jnr/2024/34983","url":null,"abstract":"In this study, the anti-convulsant effect of Sinapis alba seed oil and its combination with sodium valproate was evaluated in Wistar albino rats using the lithium-pilocarpine Status Epilepticus (SE) model. The experimental groups included: Group I - normal control; Group II - disease control; Group III - Sinapis alba seed oil; Group IV - sodium valproate; Group V - Sinapis alba seed oil + ½ dose sodium valproate. Antioxidant markers and Brain-Derived Neurotrophic Factor (BDNF) levels were measured from the brain samples. The pathological changes were also determined using Cresyl violet staining. Sinapis alba oil did not prevent rats from developing status epilepticus but reduced the intensity and frequency of occurrence. Oil administration increased antioxidant levels and decreased lipid peroxide levels as well. The combination of oil and sodium valproate showed a synergistic effect in the status epilepticus model. The study results show that Sinapis alba can be used as an adjuvant in status epilepticus along with other antiepileptic drugs.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The presence of a component, impurity, or other unfavourable element that taints, corrupts, infects, renders unfit, or degrades a material, or natural environment is referred to as environmental contamination. Due to the potential negative effects caused by the chemical discharges, environmental issues have now become crucial factors to consider. Petrochemical wastes are one of the most serious environmental contaminants which comprise a large group of chemicals derived from petroleum and natural gases. The petrochemical pollutants, belonging to the groups such as greenhouse gases, volatile organic compounds, Particulate Matter (PM) with heavy metals, and polycyclic aromatic compounds, act as potential soil contaminants, causing disturbance and harm to the soil ecosystem. Phytoremediation is an emerging and eco-friendly way to mitigate petrochemical contamination of soil. It is an in situ technique to purify contaminated soil or water using plants (trees, shrubs, grasses and aquatic plants) and their associated microorganisms. This technique is favourable for tropical countries like India where there is immense growth of plants. Though plants like Mirabilis jalapa, Italian ryegrass, sorghum, maize, and alfalfa are used worldwide, in Assam also various plant species are used for remediation purposes in petrochemical-contaminated soil. Crotalaria pallida, Cyperus brevifolius, Cynodondactylon. Mimosa pudica etc. are some of the plant species that have been reported to possess the ability to degrade toxic chemicals into non-toxic or less-toxic products with the aid of microbial colonies in the soil. This review is an effort to through some light on the plants of Assam as well as worldwide along with their family in the remediation of petroleum-contaminated soil. Thus, it will be helpful to select appropriate plants for the purpose of phytoremediation.
{"title":"Phytoremediation: An Approach for Petrochemical Contaminated Soil of Assam","authors":"Jupitora Devi, Sanjib Kalita, Priyakshi Kashyap, Krishna Borgohain","doi":"10.18311/jnr/2024/34917","DOIUrl":"https://doi.org/10.18311/jnr/2024/34917","url":null,"abstract":"The presence of a component, impurity, or other unfavourable element that taints, corrupts, infects, renders unfit, or degrades a material, or natural environment is referred to as environmental contamination. Due to the potential negative effects caused by the chemical discharges, environmental issues have now become crucial factors to consider. Petrochemical wastes are one of the most serious environmental contaminants which comprise a large group of chemicals derived from petroleum and natural gases. The petrochemical pollutants, belonging to the groups such as greenhouse gases, volatile organic compounds, Particulate Matter (PM) with heavy metals, and polycyclic aromatic compounds, act as potential soil contaminants, causing disturbance and harm to the soil ecosystem. Phytoremediation is an emerging and eco-friendly way to mitigate petrochemical contamination of soil. It is an in situ technique to purify contaminated soil or water using plants (trees, shrubs, grasses and aquatic plants) and their associated microorganisms. This technique is favourable for tropical countries like India where there is immense growth of plants. Though plants like Mirabilis jalapa, Italian ryegrass, sorghum, maize, and alfalfa are used worldwide, in Assam also various plant species are used for remediation purposes in petrochemical-contaminated soil. Crotalaria pallida, Cyperus brevifolius, Cynodondactylon. Mimosa pudica etc. are some of the plant species that have been reported to possess the ability to degrade toxic chemicals into non-toxic or less-toxic products with the aid of microbial colonies in the soil. This review is an effort to through some light on the plants of Assam as well as worldwide along with their family in the remediation of petroleum-contaminated soil. Thus, it will be helpful to select appropriate plants for the purpose of phytoremediation.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139391962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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