Introduction: The positive effects of exercise training in modulating cardiovascular risk factors in individuals with hypertension have been reported. The present study aimed to investigate the effects of 8 weeks of combined training and L-arginine supplementation on the serum levels of intercellular and vascular adhesion molecules (ICAM-1 and VCAM-1) and nitric oxide (NO) in postmenopausal hypertensive women. Method: The postmenopausal women with hypertension were assigned into four groups consisting of 12 individuals, including placebo (P), L-arginine (L), training (T), and training+Larginine (TL) groups. The combined training program (resistance-endurance) was conducted 3 sessions per week for 8 weeks. The L-arginine ingestion was 6 g daily. Blood sampling was performed at the beginning and the end of 8 weeks of intervention, and the levels of ICAM-1, VCAM-1, and NO were measured. The collected data were analyzed in SPPSS software (version 24), one-way ANOVA, and Tukey post hoc test. Results: The levels of ICAM-1 and VCAM-1 in the T and TL groups compared to the P and L groups significantly decreased (P<0.05). Significant increases of NO levels in the L (P=0.003), T (P<0.001), and TL (P<0.001) groups compared to the P group, and also a significant decrease in systolic and diastolic blood pressure were observed in all intervention groups in comparison to the P group (P<0.05). Conclusion: Based on the findings of the present study, L-arginine ingestion and combined training alone or combined together are effective in the reduction of blood pressure in hypertensive patients. Moreover, L-arginine was associated with amplifying combined training effectiveness in decreasing systolic blood pressure. Blood pressure reduction in the above-mentioned groups is probably exerted partly by the upregulation of NO levels
{"title":"Investigation of the Changes in Serum Intercellular and Vascular Adhesion Molecules (ICAM-1 and VCAM-1) and Nitric Oxide Levels in Response to Exercise Training and L-arginine Supplementation in Postmenopausal Hypertensive Women","authors":"","doi":"10.32592/nkums.14.3.40","DOIUrl":"https://doi.org/10.32592/nkums.14.3.40","url":null,"abstract":"Introduction: The positive effects of exercise training in modulating cardiovascular risk factors in individuals with hypertension have been reported. The present study aimed to investigate the effects of 8 weeks of combined training and L-arginine supplementation on the serum levels of intercellular and vascular adhesion molecules (ICAM-1 and VCAM-1) and nitric oxide (NO) in postmenopausal hypertensive women.\u0000Method: The postmenopausal women with hypertension were assigned into four groups consisting of 12 individuals, including placebo (P), L-arginine (L), training (T), and training+Larginine (TL) groups. The combined training program (resistance-endurance) was conducted 3 sessions per week for 8 weeks. The L-arginine ingestion was 6 g daily. Blood sampling was performed at the beginning and the end of 8 weeks of intervention, and the levels of ICAM-1, VCAM-1, and NO were measured. The collected data were analyzed in SPPSS software (version 24), one-way ANOVA, and Tukey post hoc test.\u0000Results: The levels of ICAM-1 and VCAM-1 in the T and TL groups compared to the P and L groups significantly decreased (P<0.05). Significant increases of NO levels in the L (P=0.003), T (P<0.001), and TL (P<0.001) groups compared to the P group, and also a significant decrease in systolic and diastolic blood pressure were observed in all intervention groups in comparison to the P group (P<0.05).\u0000Conclusion: Based on the findings of the present study, L-arginine ingestion and combined training alone or combined together are effective in the reduction of blood pressure in hypertensive patients. Moreover, L-arginine was associated with amplifying combined training effectiveness in decreasing systolic blood pressure. Blood pressure reduction in the above-mentioned groups is probably exerted partly by the upregulation of NO levels","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87214385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Hospital design is generally accepted as a complex task in functional dimensions. The present study examines the effect of daylight on the design of therapeutic spaces to create an effective treatment environment. This research aimed to acquaint the policy-makers of therapeutic spaces with the determining role of daylight and its related challenges. Method: To comprehend the intellectual, structural, and dynamic patterns of bibliographic backgrounds in this field of research, 121 related research were reviewed from valid research databases. Results: Studies are divided into four main categories: The first group of studies focuses on the role of natural light in improving the performance of the building (providing quality for the indoor environment and reducing energy consumption). The second group of studies focuses on the role of natural light in improving patients' health (mental and physical health). The third group considers the role of natural light in improving the efficiency of medical staff and the fourth group considers the role of natural light in alleviating environmental pollution. Conclusion: Review of the related literature shows that enhanced access to daylight in medical spaces is associated with reduced energy consumption, improved efficiency of health care delivery, and shortening the length of hospital stay. Optimizing medical spaces on this basis, in addition to satisfying users, will significantly reduce the cost of health care and positively impact the economic sustainability of these spaces.
{"title":"A Review of Theoretical Approaches to Light Therapy in Therapeutic Spaces","authors":"Seyed Reza Hosseini, Seyed Majid, Mofidi Shemirani, Eraj Etesam","doi":"10.32592/nkums.14.4.112","DOIUrl":"https://doi.org/10.32592/nkums.14.4.112","url":null,"abstract":"Introduction: Hospital design is generally accepted as a complex task in functional dimensions. The present study examines the effect of daylight on the design of therapeutic spaces to create an effective treatment environment. This research aimed to acquaint the policy-makers of therapeutic spaces with the determining role of daylight and its related challenges.\u0000Method: To comprehend the intellectual, structural, and dynamic patterns of bibliographic backgrounds in this field of research, 121 related research were reviewed from valid research databases.\u0000Results: Studies are divided into four main categories: The first group of studies focuses on the role of natural light in improving the performance of the building (providing quality for the indoor environment and reducing energy consumption). The second group of studies focuses on the role of natural light in improving patients' health (mental and physical health). The third group considers the role of natural light in improving the efficiency of medical staff and the fourth group considers the role of natural light in alleviating environmental pollution.\u0000Conclusion: Review of the related literature shows that enhanced access to daylight in medical spaces is associated with reduced energy consumption, improved efficiency of health care delivery, and shortening the length of hospital stay. Optimizing medical spaces on this basis, in addition to satisfying users, will significantly reduce the cost of health care and positively impact the economic sustainability of these spaces.","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83517109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Trust is among the social determinants of health in the elderly. Considering the importance of trust, this study was conducted to investigate demographic, economic, social, and health factors affecting trust in the elderly over 60 years old. Method: This cross-sectional study was based on the data of the second phase of the Urban Health Equity and Response Tool (Urban HERAT-2) on 5,760 elderly people. The economic status of the household was measured by principal component analysis and based on the variables of living supplies and facilities. Then, demographic and socio-economic variables such as the economic score of the household, ethnicity, occupation, education, and self-reported physical and mental health were presented in the linear regression of the explanatory model of trust using STATA software. Results: Based on the findings of this study, The living supplies and facilities explained 0.58 of the variances of the economic score of the household. Furthermore, it was observed that being married, having seasonal and permanent labor jobs, and being relatively poor was associated with a decrease in trust in the elderly and the ability to read and write, good self-reported physical health, and unchanged with an increase in trust in the elderly. The variables of age, gender, retirement, ethnicity, and mental health were not related to trust in the elderly. Conclusion: The variables such as labor jobs, low education, and poor economic status affected trust in the elderly. The findings of this study showed the lack of institutional and intergroup trust in the elderly, and it requires the attention of policymakers
{"title":"Factors Affecting Trust in the Elderly Based on Data from the Second Phase of the Urban Health Equity and Response Tool","authors":"","doi":"10.32592/nkums.14.3.52","DOIUrl":"https://doi.org/10.32592/nkums.14.3.52","url":null,"abstract":"Introduction: Trust is among the social determinants of health in the elderly. Considering the importance of trust, this study was conducted to investigate demographic, economic, social, and health factors affecting trust in the elderly over 60 years old. Method: This cross-sectional study was based on the data of the second phase of the Urban Health Equity and Response Tool (Urban HERAT-2) on 5,760 elderly people. The economic status of the household was measured by principal component analysis and based on the variables of living supplies and facilities. Then, demographic and socio-economic variables such as the economic score of the household, ethnicity, occupation, education, and self-reported physical and mental health were presented in the linear regression of the explanatory model of trust using STATA software. Results: Based on the findings of this study, The living supplies and facilities explained 0.58 of the variances of the economic score of the household. Furthermore, it was observed that being married, having seasonal and permanent labor jobs, and being relatively poor was associated with a decrease in trust in the elderly and the ability to read and write, good self-reported physical health, and unchanged with an increase in trust in the elderly. The variables of age, gender, retirement, ethnicity, and mental health were not related to trust in the elderly. Conclusion: The variables such as labor jobs, low education, and poor economic status affected trust in the elderly. The findings of this study showed the lack of institutional and intergroup trust in the elderly, and it requires the attention of policymakers","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89637559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Methamphetamine is a stimulant of the central nervous system that is usually misused. This study aimed to determine the effects of methamphetamine on the diameter and thickness of seminiferous tubules of adult male rats’ main gonad. Method: Twenty adult male rats weighted 200 to 220 gr were used in the current study. They were divided into study and control groups, each consisting of 10 rats. The study group received 2 mg per body weight of methamphetamine in the first three days and 5 mg in the next four days in peritoneum. The control group, on the other hand, received 0.5 ml per rat of physiologic serum in the the peritoneum. Twenty-four hours after the last injection, the rats were killed, and the main gonad was taken out of the scrotum. After tissue passage and dying with hematoxylin and eosin, the main gonad was observed with an optic microscope, and the results were analyzed using an independent t-test. A value of P<0.05 was considered to determine the level of significance between the two groups. Results: The findings showed that using methamphetamine significantly decreases the average diameter and thickness of the epithelium of seminiferous tubules of rats. It was also found that the weight of rats and gonads decreased, but it was not statistically significant. Conclusion: The results of this study show that methamphetamine is a poisonous compound for the main gonad of male rats due to the degeneration and atrophy of seminiferous tubules
{"title":"Investigation of Methamphetamine Effects on the Tissue Structure of the Main Gonadal in Rats","authors":"","doi":"10.32592/nkums.14.3.34","DOIUrl":"https://doi.org/10.32592/nkums.14.3.34","url":null,"abstract":"Introduction: Methamphetamine is a stimulant of the central nervous system that is usually misused. This study aimed to determine the effects of methamphetamine on the diameter and thickness of seminiferous tubules of adult male rats’ main gonad.\u0000Method: Twenty adult male rats weighted 200 to 220 gr were used in the current study. They were divided into study and control groups, each consisting of 10 rats. The study group received 2 mg per body weight of methamphetamine in the first three days and 5 mg in the next four days in peritoneum. The control group, on the other hand, received 0.5 ml per rat of physiologic serum in the the peritoneum. Twenty-four hours after the last injection, the rats were killed, and the main gonad was taken out of the scrotum. After tissue passage and dying with hematoxylin and eosin, the main gonad was observed with an optic microscope, and the results were analyzed using an independent t-test. A value of P<0.05 was considered to determine the level of significance between the two groups.\u0000Results: The findings showed that using methamphetamine significantly decreases the average diameter and thickness of the epithelium of seminiferous tubules of rats. It was also found that the weight of rats and gonads decreased, but it was not statistically significant.\u0000Conclusion: The results of this study show that methamphetamine is a poisonous compound for the main gonad of male rats due to the degeneration and atrophy of seminiferous tubules","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"35 1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76011638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Medicinal plants have played a major role in the treatment of multiple diseases for centuries. Ziziphora clinopodioides is one of these plants with well-known antibacterial properties. The present study aimed to investigate the antibacterial effects of Z. Clinopodioides essential oil and nanoemulsion. Method: After preparing and collecting the plant in spring, the samples were dried in the shade and transferred to the laboratory. Thereafter, the essential oil was extracted by Clevenger. Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were used to determine antibacterial properties. Results: Pulegone had the highest composition (44.49%) of essential oil. Particle size in 5% nanoemulsion of Z. Clinopodioides essential oil was 13.0 nm. The results demonstrated that considering the diameter zone of the no-growth, there was no significant difference between 5% nanoemulsion and 5% Z. Clinopodioides essential oil in both gram-positive and gram-negative bacteria. Conclusion: Nanoemulsion containing essential oil showed no significant difference in antibacterial activity compared to essential oil
{"title":"Evaluation of Chemical Compounds and Comparison of Antibacterial Activity of Essential Oil and Nanoemulsion Containing Essential Oil of Ziziphora clinopodioides L","authors":"","doi":"10.32592/nkums.14.3.70","DOIUrl":"https://doi.org/10.32592/nkums.14.3.70","url":null,"abstract":"Introduction: Medicinal plants have played a major role in the treatment of multiple diseases for centuries. Ziziphora clinopodioides is one of these plants with well-known antibacterial properties. The present study aimed to investigate the antibacterial effects of Z. Clinopodioides essential oil and nanoemulsion.\u0000Method: After preparing and collecting the plant in spring, the samples were dried in the shade and transferred to the laboratory. Thereafter, the essential oil was extracted by Clevenger. Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus were used to determine antibacterial properties.\u0000Results: Pulegone had the highest composition (44.49%) of essential oil. Particle size in 5% nanoemulsion of Z. Clinopodioides essential oil was 13.0 nm. The results demonstrated that considering the diameter zone of the no-growth, there was no significant difference between 5% nanoemulsion and 5% Z. Clinopodioides essential oil in both gram-positive and gram-negative bacteria.\u0000Conclusion: Nanoemulsion containing essential oil showed no significant difference in antibacterial activity compared to essential oil","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88672600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Amin Ashofteh, Sadegh Cheragh-Birjandi, H. TaheriChadorneshin
{"title":"The Effect of Resistance Training Along with Royal Jelly Supplementation on Expression of Nerve Growth Factor and Tyrosine Kinase A Receptor in the Hippocampal Tissue of Alzheimer's Rats","authors":"Amin Ashofteh, Sadegh Cheragh-Birjandi, H. TaheriChadorneshin","doi":"10.52547/nkums.14.4.1","DOIUrl":"https://doi.org/10.52547/nkums.14.4.1","url":null,"abstract":"","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84787406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effectiveness of Emotional Schema Therapy on Severity of Depression and Cognitive Emotional Regulation Strategies in Major Depression Disorder","authors":"Arezoo Ghasemkhanloo, A. Atadokht, Vahid Sabri","doi":"10.52547/nkums.14.1.38","DOIUrl":"https://doi.org/10.52547/nkums.14.1.38","url":null,"abstract":"","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82000004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahboobeh Allahyari, Z. Mirzazadeh, M. Keshtidar, G. Malekzadeh
{"title":"Determining the Effective Factors on Reviewing Appropriate Organizational Structure for Physical Education Organizations in Iranian Universities of Medical Sciences","authors":"Mahboobeh Allahyari, Z. Mirzazadeh, M. Keshtidar, G. Malekzadeh","doi":"10.52547/nkums.14.1.94","DOIUrl":"https://doi.org/10.52547/nkums.14.1.94","url":null,"abstract":"","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86885403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mahin Hamidi, Farah Lotifi Kashani, Q. Ahi, S. K. Hojjat
{"title":"Comparison of the Efficacy of Acceptance and Commitment Therapy (ACT) and Integrated Approach Among Psychological Distress in People with Suicide Attempts","authors":"Mahin Hamidi, Farah Lotifi Kashani, Q. Ahi, S. K. Hojjat","doi":"10.52547/nkums.14.1.86","DOIUrl":"https://doi.org/10.52547/nkums.14.1.86","url":null,"abstract":"","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72965723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Z. Hosseini, M. Ghaffari, S. Rakhshanderou, Yasaman Jafari, H. Shoraka
{"title":"Investigating the Reasons for Not Referring Men to Health Centers to Receive Health Services","authors":"Z. Hosseini, M. Ghaffari, S. Rakhshanderou, Yasaman Jafari, H. Shoraka","doi":"10.52547/nkums.14.1.29","DOIUrl":"https://doi.org/10.52547/nkums.14.1.29","url":null,"abstract":"","PeriodicalId":16423,"journal":{"name":"journal of north khorasan university of medical sciences","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77021688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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