An injury to the cartilage is a physical disruption of the cartilage's architecture, resulting in fluid loss and pain to the individual. The earliest possible diagnosis of various cartilage defect complications is vital to facilitate healing. Moreover, to fasten the healing process of the cartilage defect, tissue-engineered materials should have several key characteristics, including ideal porosity, and minimal cytotoxicity. The primary characteristic of polymeric hydrogel scaffolds is that they offer a moist environment that accelerates the cartilage repair and good biocompatibility. Most often, biocompatible polymers and incorporated agents (such as stem cells, drug molecules, and bioactive agents) exhibit synergistic effects, resulting in very high therapeutic indexes. This review highlights the phases of cartilage repair, types of natural and synthetic Polymer loaded hydrogels used in Cartilage tissue regeneration, and the importance of the stem cells loaded hydrogel in cartilage tissue engineering concepts.
{"title":"Polymeric hydrogel-assisted chondro regenerative approaches towards cartilage injury therapy an emerging treatment option","authors":"Dodda Ravikalyan, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun","doi":"10.55522/jmpas.v12i4.4789","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.4789","url":null,"abstract":"An injury to the cartilage is a physical disruption of the cartilage's architecture, resulting in fluid loss and pain to the individual. The earliest possible diagnosis of various cartilage defect complications is vital to facilitate healing. Moreover, to fasten the healing process of the cartilage defect, tissue-engineered materials should have several key characteristics, including ideal porosity, and minimal cytotoxicity. The primary characteristic of polymeric hydrogel scaffolds is that they offer a moist environment that accelerates the cartilage repair and good biocompatibility. Most often, biocompatible polymers and incorporated agents (such as stem cells, drug molecules, and bioactive agents) exhibit synergistic effects, resulting in very high therapeutic indexes. This review highlights the phases of cartilage repair, types of natural and synthetic Polymer loaded hydrogels used in Cartilage tissue regeneration, and the importance of the stem cells loaded hydrogel in cartilage tissue engineering concepts.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88170815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.55522/jmpas.v12i4.5561
Dyah G Rambu Kareri, Derri R. Tallo Manafe, Efrisca M Br Damanik
Vitamin D is a fat-soluble compound with antioxidant properties that are important for maintaining the body's mineral balance. Vitamin D can be obtained from exogenous sources (food) or endogenously synthesised by the skin through exposure to the sun's ultraviolet rays. Although it is a vitamin, it is also considered a hormone because it is activated by chemical reactions in the body. The aim of this study was to analyse the effect of walking on vitamin D levels and sleep quality. The research used a quasi-experimental method with a randomised pre- and post-test-controlled group design. In this study, two groups were randomised, the intervention group and the control group. Both groups were pre-tested and then post-tested to find out the difference in average vitamin D levels and sleep quality. Gender, age, BMI, systolic and diastolic blood pressure were not found to be confounding variables. There were no significant changes in the pre- and post-sleep quality scores of the control group. In addition, there was no significant difference in pre-sleep quality and a significant difference in post-sleep quality. However, there is a significant difference in changes in vitamin D levels between the control and intervention groups. There is a significant effect of walking on vitamin D levels and sleep quality.
{"title":"The impact of walking as a physical activity on vitamin D levels and sleep quality","authors":"Dyah G Rambu Kareri, Derri R. Tallo Manafe, Efrisca M Br Damanik","doi":"10.55522/jmpas.v12i4.5561","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.5561","url":null,"abstract":"Vitamin D is a fat-soluble compound with antioxidant properties that are important for maintaining the body's mineral balance. Vitamin D can be obtained from exogenous sources (food) or endogenously synthesised by the skin through exposure to the sun's ultraviolet rays. Although it is a vitamin, it is also considered a hormone because it is activated by chemical reactions in the body. The aim of this study was to analyse the effect of walking on vitamin D levels and sleep quality. The research used a quasi-experimental method with a randomised pre- and post-test-controlled group design. In this study, two groups were randomised, the intervention group and the control group. Both groups were pre-tested and then post-tested to find out the difference in average vitamin D levels and sleep quality. Gender, age, BMI, systolic and diastolic blood pressure were not found to be confounding variables. There were no significant changes in the pre- and post-sleep quality scores of the control group. In addition, there was no significant difference in pre-sleep quality and a significant difference in post-sleep quality. However, there is a significant difference in changes in vitamin D levels between the control and intervention groups. There is a significant effect of walking on vitamin D levels and sleep quality.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73918844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.55522/jmpas.v12i4.5562
Anita Lidesna Shinta Amat, Herman Pieter Louis Wungouw, P. Pakan
Coffee contains more than a thousand molecules, including phenolic compounds, vitamins, minerals and alkaloids. Caffeine, cafestol, kahweol and chlorogenic acid are related to lipid metabolism and can affect serum lipid profiles. Clinical studies have reported the effects of caffeine on cardiac arrhythmias, liver function, serum cholesterol and blood pressure. Malondialdehyde (MDA) in the human body is a by-product of free radicals (oxidative stress), which can indicate whether oxidative stress is detrimental. This study aims to analyse the effect of strong coffee on MDA levels in healthy adults. This study used a quasi-experimental design with a nonequivalent control group. This design was divided into two groups: the treatment group and the control group. The treatment group was given the treatment of drinking coffee and not eating foods that can raise cholesterol. In the control group, they did not drink coffee or eat foods that could cause increased malondialdehyde levels. The results showed that coffee increased MDA levels in 91% of the samples. Thus, strong coffee can increase malondialdehyde (MDA) levels in healthy adults.
{"title":"The effect of robust coffee towards the malondialdehyde level in healthy adults","authors":"Anita Lidesna Shinta Amat, Herman Pieter Louis Wungouw, P. Pakan","doi":"10.55522/jmpas.v12i4.5562","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.5562","url":null,"abstract":"Coffee contains more than a thousand molecules, including phenolic compounds, vitamins, minerals and alkaloids. Caffeine, cafestol, kahweol and chlorogenic acid are related to lipid metabolism and can affect serum lipid profiles. Clinical studies have reported the effects of caffeine on cardiac arrhythmias, liver function, serum cholesterol and blood pressure. Malondialdehyde (MDA) in the human body is a by-product of free radicals (oxidative stress), which can indicate whether oxidative stress is detrimental. This study aims to analyse the effect of strong coffee on MDA levels in healthy adults. This study used a quasi-experimental design with a nonequivalent control group. This design was divided into two groups: the treatment group and the control group. The treatment group was given the treatment of drinking coffee and not eating foods that can raise cholesterol. In the control group, they did not drink coffee or eat foods that could cause increased malondialdehyde levels. The results showed that coffee increased MDA levels in 91% of the samples. Thus, strong coffee can increase malondialdehyde (MDA) levels in healthy adults.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84786786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cancer is a lethal illness, and research into the development of effective anti-cancer medications is ongoing at all hours of the day and night. This is where 1,3,4-oxadiazoles come into play, since they are privileged and authenticated compounds because of their anti-cancer capabilities. In the field of drug development, 1,3,4-oxadiazole entities are characteristic heterocyclic rings with dominant anti-cancer activities. As a result, the primary goal of this article is to review the synthesis and screening of new 1,3,4-oxadiazole powerful derivatives is to determine their anti-cancer, antitumor, and other potential applications in the creation of anti-neoplastic drugs. In this study, the focus is on the 1,3,4-oxadiazole hybrids as well as the most significant bioactivity and potentiality of these anti-cancer compounds. This review article will include references to significant current reviews in the material, as well as a relevant discussion on the general background of anti-cancer medications that include 1,3,4-oxadiazole hybrids.
{"title":"Novel 1,3,4-Oxadiazole Hybrids with Antitumor and Anti-proliferative Potentials: A Comprehensive Review","authors":"Tarun Chaudhary, Prabhat Kumar Upadhyay, Deepak Prashar, Vivek Kumar, Sahil Kumar","doi":"10.55522/jmpas.v12i4.4429","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.4429","url":null,"abstract":"Cancer is a lethal illness, and research into the development of effective anti-cancer medications is ongoing at all hours of the day and night. This is where 1,3,4-oxadiazoles come into play, since they are privileged and authenticated compounds because of their anti-cancer capabilities. In the field of drug development, 1,3,4-oxadiazole entities are characteristic heterocyclic rings with dominant anti-cancer activities. As a result, the primary goal of this article is to review the synthesis and screening of new 1,3,4-oxadiazole powerful derivatives is to determine their anti-cancer, antitumor, and other potential applications in the creation of anti-neoplastic drugs. In this study, the focus is on the 1,3,4-oxadiazole hybrids as well as the most significant bioactivity and potentiality of these anti-cancer compounds. This review article will include references to significant current reviews in the material, as well as a relevant discussion on the general background of anti-cancer medications that include 1,3,4-oxadiazole hybrids.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88209714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.55522/jmpas.v12i4.5347
S. Rajsekhar, Kaur Chanchal Deep, Thakur Alok Singh
Pollution is now the main problem for man and his survival. Waste, which can originate from any source, whether mining, industrial, biological or household, is now on the priority list of all countries? The treatment and disposal of waste is a source of local and central government concern. The methods used to dispose of waste create a new problem for society. Dumping solid waste and burying it underground pollutes the soil and handling liquid waste on the ground or in water both causes pollution. Therefore, the pollution caused by the continuous disposal of wastes underground and in the water is not only harmful to the environment, but also has a negative impact on the health of living organisms. This review aims to highlight the status of several Indian states and cities that are suffering from soil and water pollution. The review will attempt to shows oil and water standards, heavy metal status, seasonal changes in soil and water pollution, contaminated agricultural crops, pollution pathways, uses and threat to living organisms.
{"title":"Soil and water pollution an update on the status of selected Indian states and cities","authors":"S. Rajsekhar, Kaur Chanchal Deep, Thakur Alok Singh","doi":"10.55522/jmpas.v12i4.5347","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.5347","url":null,"abstract":"Pollution is now the main problem for man and his survival. Waste, which can originate from any source, whether mining, industrial, biological or household, is now on the priority list of all countries? The treatment and disposal of waste is a source of local and central government concern. The methods used to dispose of waste create a new problem for society. Dumping solid waste and burying it underground pollutes the soil and handling liquid waste on the ground or in water both causes pollution. Therefore, the pollution caused by the continuous disposal of wastes underground and in the water is not only harmful to the environment, but also has a negative impact on the health of living organisms. This review aims to highlight the status of several Indian states and cities that are suffering from soil and water pollution. The review will attempt to shows oil and water standards, heavy metal status, seasonal changes in soil and water pollution, contaminated agricultural crops, pollution pathways, uses and threat to living organisms.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82719501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-08-31DOI: 10.55522/jmpas.v12i4.5284
Ayushi Sharma, A. Goel, Nandini Gupta, Bechan Sharma
The list of most useful Indian traditional medicinal plants includes Nyctanthes arbor-tristis, popularly known as Night jasmine. It is widely distributed in the sub-Himalayan regions and south of the Godavari.Each component of the plant has some significant medicinal value and can therefore be used for profit. The present review article illustrates an updated account of the analysis of different pharmacophores from the plant, N. arbor-tristis, and their potential biomedical applications. The significant pharmacological activities of different parts of the plant such as seeds, leaves, flowers, bark, and fruits, have been studied. Numerous phytochemicals contained in this plant including glycosides, flavonoids, essential oils, oleanic acid, carotene, tannic acid, lupeol, friedelin, benzoic acid, and glucose, have been studied and tested for their potential anti-inflammatory, hepatoprotective, anti-viral, anti-leishmaniasis, anti-pyretic, anti-fungal, anti-malarial, and anti-histaminic activities of N. arbor-tristis. Further, extensive research is required to unravel their effective medicinal applications against varied serious diseases.
{"title":"Phytochemicals from Nyctanthes arbor-tristis and their biomedical implications","authors":"Ayushi Sharma, A. Goel, Nandini Gupta, Bechan Sharma","doi":"10.55522/jmpas.v12i4.5284","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.5284","url":null,"abstract":"The list of most useful Indian traditional medicinal plants includes Nyctanthes arbor-tristis, popularly known as Night jasmine. It is widely distributed in the sub-Himalayan regions and south of the Godavari.Each component of the plant has some significant medicinal value and can therefore be used for profit. The present review article illustrates an updated account of the analysis of different pharmacophores from the plant, N. arbor-tristis, and their potential biomedical applications. The significant pharmacological activities of different parts of the plant such as seeds, leaves, flowers, bark, and fruits, have been studied. Numerous phytochemicals contained in this plant including glycosides, flavonoids, essential oils, oleanic acid, carotene, tannic acid, lupeol, friedelin, benzoic acid, and glucose, have been studied and tested for their potential anti-inflammatory, hepatoprotective, anti-viral, anti-leishmaniasis, anti-pyretic, anti-fungal, anti-malarial, and anti-histaminic activities of N. arbor-tristis. Further, extensive research is required to unravel their effective medicinal applications against varied serious diseases.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74936040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Acanthus ilicifolius is an emergent aquatic plant with potential in environmental phytotechnology. The concept of phytotechnology focuses on the role of plants as a natural technology to solve environmental problems. The plant is an herb used in traditional medicine to cure illnesses ranging from skin problems to snake bites. It contains various phytochemicals, including alkaloids and glucosides, such as lignan and phenylethanoid. Therefore, this study aims to map Achantus ilicifolius extract using the bibliometric method. A bibliometric investigation was adopted through metadata planning with the keywords “Acanthus ilicifolius AND extract” from Scopus Database (1997-2021). Metadata is stored in CSV and BibTex types. Furthermore, CSV format of Scopus metadata for analysis using the counting method on VOS viewer and R-Package with a maximum number of 25 documents. Mapping results showed that the number of publications related to the Acanthus ilicifolius extract experienced a fluctuating trend, most occurring in 2014 and 2021. Most articles relating to Acanthus ilicifolius extract were published in the Journal of Ethnopharmacology. The three most prolific studies were conducted by Ramanathan T, while Babu BH (2001) is the most cited. Studies on Acanthus ilicifolius extract with a fairly high density included Aedes aegypti, phytochemicals, antimicrobial, and antibacterial activity. Meanwhile, the rarely investigated themes include immunity, target proteins, EDTA, anthelmintic, and INOS inhibitory.
棘豆是一种新兴的水生植物，在环境植物技术方面具有很大的发展潜力。植物技术的概念侧重于植物作为解决环境问题的自然技术的作用。这种植物是传统医学中用于治疗从皮肤问题到蛇咬伤等各种疾病的草药。它含有多种植物化学物质，包括生物碱和糖苷，如木脂素和苯乙醇。因此，本研究的目的是利用文献计量学的方法对青毛羊藿提取物进行图谱分析。以Scopus数据库(1997-2021)中的关键词Acanthus ilicifolius AND extract为检索对象，通过元数据规划进行文献计量学调查。元数据以CSV和BibTex两种类型存储。此外，在VOS viewer和R-Package上使用计数方法对CSV格式的Scopus元数据进行分析，最大数量为25个文档。制图结果显示，与棘叶提取物相关的出版物数量呈波动趋势，大部分发生在2014年和2021年。有关棘叶提取物的文章大多发表在《民族药理学杂志》上。三个最多产的研究是由Ramanathan T进行的，而Babu BH(2001)是被引用最多的。对密度较高的棘叶提取物进行了埃及伊蚊、植物化学成分、抗菌和抑菌活性等方面的研究。同时，很少研究的主题包括免疫、靶蛋白、EDTA、驱虫药和INOS抑制。
{"title":"The phytomedicine trends of Acanthus ilicifolius a bibliometric study","authors":"Prasojo Pribadi, Heni Setyowati Esti Rahayu, Hesti Respatiningsih, Devi Kemala Dewi, Kartika Wijayanti","doi":"10.55522/jmpas.v12i4.4690.","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.4690.","url":null,"abstract":"Acanthus ilicifolius is an emergent aquatic plant with potential in environmental phytotechnology. The concept of phytotechnology focuses on the role of plants as a natural technology to solve environmental problems. The plant is an herb used in traditional medicine to cure illnesses ranging from skin problems to snake bites. It contains various phytochemicals, including alkaloids and glucosides, such as lignan and phenylethanoid. Therefore, this study aims to map Achantus ilicifolius extract using the bibliometric method. A bibliometric investigation was adopted through metadata planning with the keywords “Acanthus ilicifolius AND extract” from Scopus Database (1997-2021). Metadata is stored in CSV and BibTex types. Furthermore, CSV format of Scopus metadata for analysis using the counting method on VOS viewer and R-Package with a maximum number of 25 documents. Mapping results showed that the number of publications related to the Acanthus ilicifolius extract experienced a fluctuating trend, most occurring in 2014 and 2021. Most articles relating to Acanthus ilicifolius extract were published in the Journal of Ethnopharmacology. The three most prolific studies were conducted by Ramanathan T, while Babu BH (2001) is the most cited. Studies on Acanthus ilicifolius extract with a fairly high density included Aedes aegypti, phytochemicals, antimicrobial, and antibacterial activity. Meanwhile, the rarely investigated themes include immunity, target proteins, EDTA, anthelmintic, and INOS inhibitory.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82018381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this article is to synthesize some novel quinoline-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help of elemental analysis, IR, NMR, and mass spectral data, the synthesized derivatives were identified. Derivatives' antibacterial activity was determined using the cup and plate diffusion method. At doses of 50 μg/ml and 100 μg/ml, the substance demonstrated substantial antibacterial potential against the tested strains. To predict the pharmacokinetic properties (ADME) of these derivatives, in-silico investigations were also carried out. For the current study, the in silico Swiss ADME-assisted results were shown to be suitable for the derivation and synthesis of efficient antibacterial drugs.
{"title":"Design synthesis in-silico study and biological evaluation of quinoline derivatives as potential antibacterial agents","authors":"Vinod Kumar Gurjar, Dodiya Raj Mukeshbhai, Kushwaha Raju, Subhash Devanshi Parekh","doi":"10.55522/jmpas.v12i4.5080","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.5080","url":null,"abstract":"The purpose of this article is to synthesize some novel quinoline-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help of elemental analysis, IR, NMR, and mass spectral data, the synthesized derivatives were identified. Derivatives' antibacterial activity was determined using the cup and plate diffusion method. At doses of 50 μg/ml and 100 μg/ml, the substance demonstrated substantial antibacterial potential against the tested strains. To predict the pharmacokinetic properties (ADME) of these derivatives, in-silico investigations were also carried out. For the current study, the in silico Swiss ADME-assisted results were shown to be suitable for the derivation and synthesis of efficient antibacterial drugs.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90243798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antibiotics are antimicrobial drugs that kill germs and are crucial in the fight against bacterial infections. These medications are widely used in the prevention and treatment of diseases because they may either kill or stop bacteria from growing. Microbial resistance refers to bacteria's capacity to survive antibiotics' bacteriostatic or cytotoxic effects. The samples for this study are taken from Song and Suswa River, Dehradun, Uttarakhand. The main aim of this study is to isolate several species to find out if them are resistant to antibiotics. The methodologies used in this research are isolation and haracterization of bacteria, antibiotics sensitivity test. There were 17 types of antibiotics were used i.e. Azithromycin, Amikacin, Cefaclor, Cefepime, Cefoxitin, Doxycycline Hydrochloride,Erythromycin, Gentamycin, Kanamycin, Levofloxacin, Mecillinam, Mezolocilline, Penicillin G, Vancomycin, Tetracycline, Ticarcilline, Nitrofurantoin. The result was that species like Salmonella, Pseudomonas, E. coli, Klebsiella were resistant, sensitive, and intermediate against the 17 antibiotics. Antibiotic-resistant bacteria can potentially be transferred from one to another in a society. This is gradually getting frequent these days. In short, antibiotic resistance cannot be prevented or, in some cases, reversed, but we can certainly slow its progression.
{"title":"Isolation and characterization of multi drug resistance bacterial pathogens from Song and Suswa river water in Dehradun","authors":"Rakesh Pant, Amit Gupta, Bharat Rohilla, Arsh Singh, Priya Arya, Sunidhi Shreya, Nirmal Patrick, Vijay Kumar","doi":"10.55522/jmpas.v12i4.4399","DOIUrl":"https://doi.org/10.55522/jmpas.v12i4.4399","url":null,"abstract":"Antibiotics are antimicrobial drugs that kill germs and are crucial in the fight against bacterial infections. These medications are widely used in the prevention and treatment of diseases because they may either kill or stop bacteria from growing. Microbial resistance refers to bacteria's capacity to survive antibiotics' bacteriostatic or cytotoxic effects. The samples for this study are taken from Song and Suswa River, Dehradun, Uttarakhand. The main aim of this study is to isolate several species to find out if them are resistant to antibiotics. The methodologies used in this research are isolation and haracterization of bacteria, antibiotics sensitivity test. There were 17 types of antibiotics were used i.e. Azithromycin, Amikacin, Cefaclor, Cefepime, Cefoxitin, Doxycycline Hydrochloride,Erythromycin, Gentamycin, Kanamycin, Levofloxacin, Mecillinam, Mezolocilline, Penicillin G, Vancomycin, Tetracycline, Ticarcilline, Nitrofurantoin. The result was that species like Salmonella, Pseudomonas, E. coli, Klebsiella were resistant, sensitive, and intermediate against the 17 antibiotics. Antibiotic-resistant bacteria can potentially be transferred from one to another in a society. This is gradually getting frequent these days. In short, antibiotic resistance cannot be prevented or, in some cases, reversed, but we can certainly slow its progression.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135945773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.55522/jmpas.v12i3.5037
V. Mastiholimath, Sujit Prabhu Khope, Pallavi Chiprikar, A. Ammanage, U. Patel
Meclizine Hydrochloride belongs to class H1 antagonist, antiemetic and anti-vertigo in nature, it is a Biopharmaceutical classification system (BCS) class II drug and is practically insoluble in water. The bottom-up approach was used in the formulation of nanosuspension in which methanol and millipore water was used as solvent and anti-solvent respectively, the stabilizers used for preparation were Polyvinylpyrrolidone K30 (PVP K30) and Hydroxypropyl Methylcellulose E15 (HPMC E15) which were found to be compatible with the formulation after Fourier Transform Infrared (FTIR) and Differential scanning calorimeter (DSC) studies. Mouth dissolving films were formulated by solvent casting method using glycerine lubricated petri dish and were kept for heating in a hot air oven at 45°C overnight. Characterization of nanosuspension-loaded mucoadhesive mouth dissolving films was done by evaluating various characteristics, the highest drug content was found to be 92.43±0.49% in Mouth dissolving film (MDF) 2. In-vitro drug release studies indicate that nanosuspension-loaded mucoadhesive mouth-dissolving film has a rapid drug release rate as compared to plain drug-loaded mouth-dissolving films and marketed tablet formulation.
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