Journal of Nervous and Mental Disease最新文献

Abstract: This review aimed at summarizing the literature evidence on clinical, cognitive, and neurobiological correlates of impaired timing abilities in schizophrenia (SCZ). Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic literature search was conducted in PubMed, EMBASE, and PsycInfo by looking at correlates between timing abilities and either symptom severity, cognition, and neurobiological data (imaging and electroencephalography) in individuals with SCZ, without restrictions on study design. A total of 45 articles were selected: associations were identified between impaired timing performance and positive, negative, and disorganization symptoms, as well as with executive functioning, working memory, and attention. Timing impairments were associated with altered motor coordination neural circuits. Despite high methodological and clinical heterogeneity, timing dysfunction may be associated with the symptom severity and cognitive impairments in SCZ. Further studies are needed to clarify the pathophysiology of this association and offer new therapeutic targets.

Abstract: This study aimed to determine the mediating role of emotion regulation difficulties in the correlation between mindfulness and psychological resilience. This study was conducted with a total of 119 patients diagnosed with major depression. Data were collected with Personal Information Form, Mindfulness Scale, Emotion Regulation Difficulties Scale, and Psychological Resilience Scale. The study participants reported moderate levels of mindfulness and emotion regulation difficulties, and above-average levels of psychological resilience. It was found that there was a moderately negative correlation between mindfulness and emotion regulation difficulties ( r = -0.553, p < 0.001), as well as between psychological resilience and emotion regulation difficulties ( r = -0.429, p < 0.001). A moderately positive correlation was determined between mindfulness and psychological resilience ( r = 0.344, p < 0.001). Emotion regulation difficulties fully mediated the correlation between mindfulness and psychological resilience. These findings will guide the development of interventions aimed at enhancing mindfulness, emotion regulation skills, and psychological resilience in depression treatment.

Abstract: This study investigates the role of family and social relationships in cases of attempted suicide in China. Studies, mostly analyzing data from developed countries, have indicated that interpersonal relationships are important predictors of suicidal behaviors. This study's data were derived from a case-control study in China. Family relationships included relationships with spouses, parents, and parents-in-law. Poor family and social relationships were significantly associated with increased risk of attempted suicide in women and men. Depression and social support significantly mediated the association between interpersonal relationship and attempted suicide. Poor relationship with spouse was significantly associated with an elevated risk of attempted suicide. Relationship with parents-in-law was also significantly associated with attempted suicide in women, whereas family relationships played a more important role than social relationships in suicidal behaviors, especially in men. The findings imply that suicide prevention in China could be conducted from the perspective of improving family relationships, especially husband/wife and parents/daughters-in-law relationships.

Abstract: Sexual violence is associated with posttraumatic stress disorder (PTSD), but relatively less research has explored whether it is associated with hazardous drinking. PTSD symptoms may indirectly influence the association between sexual violence and hazardous alcohol use. This association may be moderated by gender. The aim of the current study was to cross-sectionally test whether sexual violence is indirectly associated with hazardous drinking through PTSD symptoms and explore whether gender moderates this association. Hypotheses were tested among 631 adults ( Mage = 38, 56% men, 78.6% White) with probable PTSD and hazardous drinking who completed online self-report surveys. Results indicated sexual violence, compared with other trauma types, was associated with more severe hazardous drinking. There was a significant indirect effect of PTSD symptoms in this association. There was no evidence of a moderating effect of gender. PTSD symptoms may drive hazardous drinking among sexual violence survivors. Results also underscore associations between sexual violence and alcohol use, regardless of gender. Future work should continue to investigate these associations prospectively.

Abstract: Lifetime history of suicide attempts is associated with inflammatory mechanisms, severity of depressive symptoms, and childhood trauma. This cross-sectional study enrolled 54 suicide attempters and 154 nonsuicide attempters. All individuals were assessed through a questionnaire, a structured clinical interview, scales, anthropometric measures, and laboratory biomarkers. Individuals with a history of lifetime suicide attempts showed significant positive correlations regarding soluble tumor necrosis factor receptor 1 and severity of depressive symptoms (p = 0.013), interleukin-1 receptor antagonist and severity of depressive symptoms (p = 0.04), and absenteeism from work and childhood physical abuse (p = 0.012). Suicide attempters also experienced more childhood trauma (sexual abuse, physical abuse, emotional abuse, emotional neglect, and physical neglect) compared with nonsuicide attempters. IL-4 levels were significantly lower in individuals who attempted suicide than in nonsuicidal individuals. Lifetime suicide attempts in major affective disorders were associated with childhood trauma and proinflammatory and anti-inflammatory cytokines.

Abstract: The presence of specific craniofacial deviations may be evidence of abnormal early brain development in bipolar disorder (BD). This study aimed to compare mandibular morphology in patients with BD versus nonpsychiatric controls using panoramic radiography. A total of 215 recorded images, 70 patients with BD and 145 controls, were evaluated. Seven mandibular parameters of the ramus height (RH), condylar height (CH), gonial angle (GA), antegonial angle (AGA), antegonial notch depth (AND), ramal notch depth (RND), and bigonial width (BGW) were measured in a blinded manner. Group analysis was conducted separately for males and females. The univariate comparisons showed increased values in RH, CH, AND, RND, and BGW and decreased values in GA in males with BD compared with male controls. In addition, females with BD had higher RH, CH, RND, and BGW values in comparison to female controls. The differences were statistically significant. Data from multivariate analyses revealed that increases in RH and BGW values in both sexes were significant predictive variables that distinguished patients with BD from controls. Moreover, deeper AND was the most prominent predictor that distinguished male patients with BD from male controls. The identification of subtle changes in mandibular measurements is consistent with the notion of impaired neurodevelopment in BD.

Abstract: Rituals represent a prominent human behavior in different contexts such as daily routines, life cycle stages, and psychopathology, for example, obsessive compulsive disorder (OCD) where they are referred to as compulsions. OCD compulsions differ from habitual behaviors and stereotypies regarding their formal features: acts repetition, the addition of nonfunctional acts, and attentional focus on basic motor units. This study aims to categorize OCD compulsions based on the motor patterns of acts repetition and inclusion of nonfunctional acts. We analyzed 28 video-recorded OCD compulsions; we adopted a cluster analytic model to identify distinct patterns within the data and determine cluster characteristics. Our findings revealed a moderate negative covariance between nonfunctionality and repetitiveness, indicating that as nonfunctionality increased, repetitiveness decreased. Three distinct clusters in OCD rituals were identified according to the motor pattern: "idiosyncratic rituals," characterized by strong incorporation of nonfunctional acts; "iterative rituals" showing high repetitiveness; and "routines," with minimal repetition and limited inclusion of nonfunctional acts. These motor patterns highlight evolutionarily conserved behavioral strategies aimed at coping with conditions of environmental unpredictability. The findings might allow fine-grained discrimination of ritual compulsions and help target personalized interventions.

Abstract: Alexithymia presents a reduced ability to identify, express, and describe one's own emotions. In medical professionals, alexithymia is associated with increased burnout and substance use, as well as reduced altruistic behavior. Our aim was to examine the association between alexithymia and different sociodemographic, psychological, and somatic parameters among medical students. Participants included 186 third- and sixth-year students of the Faculty of Medicine in Belgrade, Serbia. Data were collected through an online survey, composed of 1) a general questionnaire (sociodemographic data, education satisfaction, grade point average, presence of psychological and somatic disorders), 2) Twenty-Item Toronto Alexithymia Scale, 3) Patient Health Questionnaire-9, and 4) Beck Anxiety Inventory. Third-year students had significantly higher rates of alexithymia compared with sixth-year students. Negative correlation was found between alexithymia and educational satisfaction ( r = -0.276**) and alexithymia and grade point average ( r = -0.186*). A positive correlation was found between alexithymia and depression ( r = 0.424**) and alexithymia and anxiety ( r = 0.338**). The negative impact of alexithymia on educational satisfaction and psychological health is pronounced in the population of medical students, indicating a need for preventive programs aimed in medical schools.