Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Assessment of tissue factor pathway inhibitor 2 (TFPI2) as a novel serum marker for malignant tumors of the ovary before and after treatment: A case-control study","authors":"Yuki Ogawara,&nbsp;Naho Ruiz Yokota,&nbsp;Yuki Yamada,&nbsp;Noriaki Arakawa,&nbsp;Kentaro Sakamaki,&nbsp;Hiroshi Kobayashi,&nbsp;Kazumi Kubota,&nbsp;Fuminori Kimura,&nbsp;Taichi Mizushima,&nbsp;Etsuko Yamazaki,&nbsp;Etsuko Miyagi","doi":"10.1111/jog.16241","DOIUrl":"https://doi.org/10.1111/jog.16241","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Tissue factor pathway inhibitor 2 (TFPI2) is a preoperative biomarker that was developed to discriminate ovarian benign tumors from cancer and is covered by health insurance in Japan. The purpose of this study was to evaluate how the TFPI2 changes after treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Serum levels of TFPI2 (cut off 191 pg/mL) and CA125 (cut off 35 U/mL) before and after primary debulking surgery in patients with ovarian malignant tumors were evaluated among recurrent and nonrecurrent cases, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 46 cases were analyzed, including 11 borderline tumors, 13 clear cell carcinomas, 15 serous carcinomas, 4 endometrioid carcinomas, and 3 mucinous carcinomas. Among 37 patients without recurrence, the preoperative mean levels of TFPI2 (235.3 pg/mL, range: 78.3–607.7) and CA125 (1125.5 U/mL, range: 6.2–6272.0) were higher than the cutoff values. The mean minimum level of TFPI2 decreased to below the cutoff (150.2 pg/mL, range 56.4–471.1) at 3 months or more after primary debulking surgeries. The postoperative TFPI2 level exceeded the cutoff in 11 out of 37 patients without recurrence (29.7%); however, the postoperative TFPI2 level decreased in 8 patients. The mean maximum levels of TFPI2 and CA125 in 9 patients after recurrence were 492.6 pg/mL and 727.4 U/mL, respectively. Moreover, the mean TFPI2 level was higher than the preoperative one (421.5 pg/mL), different from CA125 (2903.8 U/mL).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results suggest the clinical validity of TFPI2 as a serum tumor marker for postoperative recurrence screening among malignant ovarian tumors.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jog.16241","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clomiphene citrate + letrozole add-on versus classical ovarian stimulation protocols in diminished ovarian reserve patients","authors":"Mehmet Tunç,&nbsp;Göğşen Önalan","doi":"10.1111/jog.16245","DOIUrl":"https://doi.org/10.1111/jog.16245","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate if there is any benefit of adding clomiphene citrate (CC) + letrozole to controlled ovarian stimulation (COS) cycles on the total gonadotropin dose in POSEIDON group 4 diminished ovarian reserve (DOR) patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 61 DOR patients who underwent 150 COS cycles between 2020 and 2023 in our center were investigated retrospectively. The patients were divided into three main subgroups: group A, group B, and group C. In group A, gonadotropin stimulation started after the completion of 5 days of co-treatment with CC (50 mg twice daily) and letrozole (2.5 mg twice daily). In group B, patients received gonadotropins after completing 5 days of letrozole (2.5 mg twice, daily), and in group C, patients started gonadotropins only.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean age was higher in groups A and B. Body mass index, previous parity, and mean AMH levels were similar between the groups. Day 2 antral follicle count was significantly lower in group A (0.90, 1.45 and 1.53; <i>p</i> = 0.017). The need for gonadotropins was lower in group A compared to groups B and C (<i>p</i> = 0.131, and <i>p</i> = 0.029; respectively). Cycle cancellation rates, follicle count on trigger day, number of mature oocytes, number of cleavage stage embryos, and number of blastocyst stage embryos were similar between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>CC + letrozole co-treatment before starting gonadotropin stimulation in POSEIDON group 4 DOR patients might reduce the need for gonadotropins, with similar live birth rates in COS cycles.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution of pelvic postoperative spindle cell nodule with sarcomatous onset after 9 years of follow-up","authors":"Ayumu Matsuoka,&nbsp;Akira Mitsuhashi,&nbsp;Hirokazu Usui,&nbsp;Satoyo Otsuka,&nbsp;Kyoko Nishikimi,&nbsp;Shinichi Tate,&nbsp;Rie Okuya,&nbsp;Takuya Yazawa,&nbsp;Makio Shozu,&nbsp;Kaori Koga","doi":"10.1111/jog.16238","DOIUrl":"https://doi.org/10.1111/jog.16238","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Postoperative spindle cell nodules are benign and reactive lesions that occur at the previous surgical site. It often develops like a sarcoma and is resected via highly invasive procedures. To date, there have been no published reports on the natural progression of postoperative spindle cell nodules without surgical intervention.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case</h3>\u0000 \u0000 <p>A 45-year-old woman underwent a total abdominal hysterectomy for leiomyoma. A 5-cm pelvic mass exposed in the vaginal stump developed 7 weeks later, causing genital bleeding. Positron emission tomography–computed tomography revealed a pelvic mass and an enlarged pelvic lymph node with high uptake. We suspected an invasive sarcoma in the pelvis. However, through a transvaginal needle biopsy, the mass was diagnosed as a postoperative spindle cell nodule posthysterectomy. The nodule slowly reduced in size and completely disappeared 9 years posthysterectomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Correct diagnosis of this nodule with sarcomatous onset based on biopsy was important to avoid unnecessary surgeries. The lesion completely disappeared spontaneously after long-term follow-up.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IGF2BP1 promotes endometriosis by enhancing m6A modification stability of HMGB1","authors":"Xin Wei,&nbsp;Yanlin Su,&nbsp;Wencai Tian,&nbsp;Li Cheng,&nbsp;Ling Yin,&nbsp;Xiaoxia He","doi":"10.1111/jog.16242","DOIUrl":"https://doi.org/10.1111/jog.16242","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Endometriosis is a chronic inflammatory condition afflicting women of reproductive age. Our study aims to clarify the function and mechanism of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and high mobility group box 1 protein (HMGB1) in endometriosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>HMGB1 and various N6-methyladenosine (m6A) reader protein levels were assessed in normal, eutopic, and ectopic endometrial tissue, and a correlation analysis was conducted. The impact of IGF2BP1 knockdown on endometriosis was assessed both in vivo in rat models and in vitro in ectopic endometrial stromal cells (eESCs) using methods such as immunoblotting and mRNA quantification. The binding of IGF2BP1 to HMGB1 mRNA in eESCs was assessed using RIP-PCR. Following transfection with sh-IGF2BP1 and oe-HMGB1, the expression of IGF2BP1 and HMGB1, as well as cell proliferation, invasion, and migration abilities, were measured in eESCs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In ectopic endometrial tissue, IGF2BP1 and HMGB1 were elevated and positively correlated. Inhibition of IGF2BP1 reduced eESC proliferation, migration, invasion, and glucose intake. Meanwhile, HMGB1, PKM2, and HK2 expression were depressed. In vivo, results were consistent with in vitro. Additionally, in vivo experiments confirmed that inhibition of IGF2BP1 resulted in reduced ectopic endometrial lesion spherical volume, weight, and interstitial lesions. IGF2BP1 bound to HMGB1 mRNA and enhanced its stability by m6A modification. Conversely, when IGF2BP1 was knocked down and HMGB1 was overexpressed, the results were opposite to those observed previously.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>IGF2BP1 promotes endometriosis progression by enhancing m6A modification stability of HMGB1. This study provides a theoretical basis for identifying therapeutic targets for endometriosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of opportunistic bacterial pathogens with female infertility: A case–control study","authors":"Zahid Hasan,&nbsp;Nurjahan Begum,&nbsp;Sangita Ahmed,&nbsp;Mahmuda Yasmin","doi":"10.1111/jog.16243","DOIUrl":"https://doi.org/10.1111/jog.16243","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Infertility affects a significant proportion of women worldwide, and the colonization of certain vaginal pathogens has been suggested as a possible contributing factor. To explore the relationship between bacterial pathogens and female infertility, a case–control study was conducted involving 55 infertile women as cases and 5 fertile women as controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Conventional culture-based techniques and biochemical assays followed by 16S rDNA sequence analysis were employed for the identification of vaginal isolates from the two groups. The strength of association between the isolated bacterium and infecundity was derived by odds ratio calculation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The investigation revealed the presence of bacteria including <i>Enterococcus faecalis</i>, <i>Escherichia coli</i>, <i>Bacillus</i> spp., <i>Acinetobacter baumannii</i>, <i>Pseudomonas</i> spp., <i>Micrococcus luteus</i>, <i>Staphylococcus aureus</i>, <i>Staphylococcus haemolyticus</i>, <i>Staphylococcus hominis</i>, <i>Staphylococcus capitis</i>, <i>Staphylococcus epidermidis</i>, and <i>Staphylococcus saprophyticus</i> in the vaginal swabs of infertile women. Of these, the odds ratios for <i>Staphylococcus aureus</i>, <i>Klebsiella pneumoniae</i>, <i>E. faecalis</i>, and <i>E. coli</i> were 5.43 (95% CI = 0.28, 103.49), 4.59 (95% CI = 0.24, 87.93), 2.25 (95% CI = 0.11, 44.16), and 1.70 (95% CI = 0.09, 34.01), respectively, displaying an association with infertility. Moreover, vaginal colonization of these four bacterial species was also dominant in cases that were diagnosed with pelvic inflammatory disease and idiopathic infertility by laparoscopic examination.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Overall, the findings of this study indicate a probable association between specific pathogenic microorganisms and women's barrenness, emphasizing the significant role of these disease-causing agents in hindering conception. This highlights the significance of a complete understanding of the vaginal microbiome and emphasizes further research in this area.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference line lengthening on resting-state magnetic resonance imaging in patients with pelvic organ prolapse seeking surgical treatment","authors":"Yoshiyuki Okada,&nbsp;Chie Nakagawa,&nbsp;Ippei Kurokawa,&nbsp;Miwa Shigeta,&nbsp;Yukiko Nomura,&nbsp;Eisuke Inoue,&nbsp;Yasukuni Yoshimura","doi":"10.1111/jog.16248","DOIUrl":"https://doi.org/10.1111/jog.16248","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Injury to and laxity of the pelvic floor muscles are highly important factors in the etiology of pelvic organ prolapse. When women with pelvic organ prolapse perform the Valsalva maneuver, progressive descent and widening of the levator ani muscle are observed on dynamic magnetic resonance images. However, physical examination of such women often reveals pelvic floor laxity, even in a relaxed state. Therefore, we aimed to verify the hypothesis that sagging of the pelvic floor can be detected on resting-state magnetic resonance images in the supine position.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively evaluated resting-state magnetic resonance imaging findings in women with (<i>n</i> = 193; all underwent surgical treatment) and without (controls; <i>n</i> = 193) pelvic organ prolapse who had at least one prior vaginal delivery. We compared the lengths of the pubococcygeal line, H-line, and M-line between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median lengths (interquartile ranges) for the prolapse and control groups were 98.3 (91.9–104.0) and 95.1 (90.3–101.4) mm (<i>p</i> = 0.0011), respectively, for the pubococcygeal line; 61.5 (56.0–67.9) and 51.1 (47.2–55.6) mm (<i>p</i> &lt; 0.0001), respectively, for the H-line; and 24.6 (20.4–29.0) and 8.6 (3.9–13.0) mm (<i>p</i> &lt; 0.0001), respectively, for the M-line. Similarly, in the multiple regression analysis adjusted for age, height, body mass index, a history of operative vaginal delivery, and a history of hysterectomy, the pubococcygeal line, H-line, and M-line were significantly longer in the prolapse group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In women with pelvic organ prolapse, the H-line and M-line are significantly longer on resting-state magnetic resonance images, allowing for the detection of pelvic floor relaxation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trimethylamine N-oxide induces pyroptosis in HTR8-S/Vneo cells through the ten-eleven translocation 2-cytochrome b-reactive oxygen species pathway","authors":"Lingli Liang,&nbsp;Yuzhu Rao,&nbsp;Jingjing Wang,&nbsp;Jinli Zhao,&nbsp;Lu He,&nbsp;Jun Meng,&nbsp;Peng Wu,&nbsp;Zuo Wang","doi":"10.1111/jog.16237","DOIUrl":"https://doi.org/10.1111/jog.16237","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Aim&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Pyroptosis is a type of programmed cell death characterized by pro-inflammatory activity and is an important factor in pre-eclampsia (PE). Trimethylamine N-oxide (TMAO) is a gut microbial metabolite closely associated with pyroptosis and PE. This study aims to investigate the role of TMAO in trophoblast cell pyroptosis and explore possible mechanisms.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Western blot and qRT-polymerase chain reaction (PCR) were used to detect the expression levels of ten-eleven translocation 2 (TET2), cytochrome b (CYTB), pyroptosis-related molecules, and mitochondrial proteins. The level of mitochondrial reactive oxygen species (mtROS) was detected by fluorescent probe DCFH-DA. Immunofluorescence was used to measure the level of 5-hydroxymethylcytosine (5hmC). TET2 overexpression/silencing and CYTB overexpression/silencing lentiviruses were transfected into HTR8/SVneo cells, respectively. MitoTEMPO was used to reduce mtROS. TMAO levels in placental tissues were quantified by liquid chromatography-tandem mass spectrometry (LC–MS/MS), and representative extracted ion chromatograms were analyzed for retention times and peak areas. ELISA was used to further validate TMAO concentrations in placental tissues.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;TMAO is capable of enhancing the expression of proteins related to pyroptosis (including NLRP3, GSDMD, GSDMD-N, Caspase-1) as well as inflammatory factors (such as IL-1β, IL-18) in HTR8-S/Vneo cells. Meanwhile, the positive rate of propidium iodide (PI), mtROS levels, and intracellular Ca2+ levels all increased. Electron microscopy results showed an increase in mitochondrial membrane pore numbers, abnormal mitochondrial morphology, and downregulation of the expression levels of mitochondrial proteins nuclear respiratory factor 1 (NRF1), NRF2, peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), and NADH dehydrogenase subunit 2 (ND2). LC–MS/MS and ELISA analyses revealed significantly elevated TMAO levels in PE placental tissues compared to normal tissues, further supporting the role of TMAO accumulation in placental dysfunction associated with PE. Overexpression of CYTB inhibited TMAO-induced pyroptosis and mitochondrial dysfunction (MDF) in HTR8-S/Vneo cells, while silencing of CYTB promoted pyroptosis and MDF in HTR8-S/Vneo cells, but this condition could be partially reversed by MitoTEMPO. TMAO inhibited the expression of TET2 and CYTB and downregulated the level of 5hmc. The results of TET2 overexpression/knockout indicated that the expression of CYTB was regulated by TET2, and overexpression of TET2 alleviated TMAO-induced pyroptosis and MDF as well as the decrease in 5hmc lev","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effect of Kegel plus abdominal exercises and Kegel only exercises on urinary incontinence severity, quality of life, and sleep quality in postmenopausal women with stress urinary incontinence: A randomized controlled trial","authors":"Şükran Başgöl,&nbsp;Emine Koç,&nbsp;Meltem Mecdi Kaydırak","doi":"10.1111/jog.16233","DOIUrl":"https://doi.org/10.1111/jog.16233","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The purpose of this study was to compare the effect of Kegel exercises plus abdominal exercises to Kegel only exercises on urinary incontinence severity, quality of life, and sleep quality in postmenopausal women with stress urinary incontinence (SUI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective, randomized controlled trial adhered to the CONSORT guidelines and included 70 postmenopausal women (35 in each group) diagnosed with SUI who attended an Obstetrics and Gynecology outpatient clinic in northern Turkey between May and November 2023. The experimental group performed Kegel and abdominal exercises, while the control group practiced Kegel exercises only. Both groups followed a 12-week exercise program, with data collected through pre- and post-tests and three face-to-face interviews during the intervention period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the 12-week exercise programs, both Kegel only and Kegel plus abdominal exercise combination decreased the severity of incontinence and improved quality of life and sleep quality in postmenopausal women with SUI (<i>p</i> &lt; 0.001). However, in this population, Kegel plus abdominal exercises give better results than Kegel only exercises (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>According to the outcome of this evidence-based study, it is recommended that exercise programs combining Kegel and abdominal exercises be established for postmenopausal women with SUI within the scope of conservative treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to “Letter to Human-written versus ChatGPT-generated case reports”","authors":"Shigeki Matsubara","doi":"10.1111/jog.16240","DOIUrl":"https://doi.org/10.1111/jog.16240","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143404705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut microbiota and potential serum metabolites biomarkers of pregnant woman for preeclampsia","authors":"Qingju Meng,&nbsp;Jingjin Gong,&nbsp;Junwei Wu,&nbsp;Fang Chen,&nbsp;Yanqiu Li","doi":"10.1111/jog.16229","DOIUrl":"https://doi.org/10.1111/jog.16229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The pathogenesis of preeclampsia (PE) remains unclear, but the interaction between intestinal flora and PE has been attention in recent studies. Several studies have shown that imbalanced intestinal flora plays an important role in the inducement of PE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The potential correlation among intestinal flora, metabolites, and fetal growth restriction was explored by integrating data and analyzing neonatal growth. The study is hoped to provide references for subsequent studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comparison between the intestinal flora of healthy pregnant women and pregnant with PE was conducted using 16S rRNA gene sequencing. Subsequently, the feces, serum and umbilical cord blood collected from healthy pregnant women and those with PE were analyzed using global untargeted metabolomics to identify differences in metabolites.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that <i>Bifidobacterium</i>, <i>Chryseobacterium</i>, <i>Eubacterium</i>, <i>Pravotella</i> and <i>Bacteroides</i> are the core species associated with many metabolites. Normal-birth weight had a negative correlation with the abundance of raclopride, Phe-Gly-O and Lys-Phe-OH showed a positive correlation with Phosphonate and Lys-Gly. Simultaneously, these core metabolites showed a strong correlation with other growth indices (BPD, AC, FL). In summary, the imbalance of intestinal flora in pregnant women may alter the abundance of the core metabolites, thereby affecting the neonatal growth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A global untargeted metabolomics was performed on the samples including feces, serum, and umbilical cord blood. The integrated multi-omics analysis revealed the interaction among intestinal flora, metabolites and the clinical indices, demonstrating the potential effects of the imbalance of intestinal flora on neonatal growth in the pregnant women with PE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}