To determine the association of combined oral contraceptives (COCs) use and endometrial cancer risk in Southeast Asian women.
Methods
This is a secondary analysis of a previously conducted multicenter case–control study with the recruitment between 2015 and 2021. Cases were women with histologically confirmed diagnoses of endometrial cancer. Controls were women admitted to different wards for other medical conditions and were individually matched to cases by age and admission date, at a ratio of three controls per case. Data regarding contraception practices were collected through interviews conducted by trained personnel using a standardized questionnaire. Conditional logistic regression models were used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).
Results
In total, 115 (30.4%) out of 378 cases and 574 (50.6%) out of 1134 controls reported a history of COCs use. The odds of endometrial cancer were lower in women who had ever used COCs than those who reported never use (aOR 0.60; 95% CI 0.44–0.82). For every additional 12 months of COCs use, the odds of endometrial cancer decreased by 10% (aOR 0.90; 95% CI 0.86–0.93). Former COCs users had a reduced odds of endometrial cancer for up to 30 years after discontinuation (aOR 0.44; 95% CI 0.25–0.77).
Conclusion
A noticeable trend was observed indicating a decline in the odds of endometrial cancer with increasing duration of COCs use. COCs users continued to receive long-term protection against endometrial cancer after discontinuation.
目的：确定东南亚妇女联合口服避孕药（COCs）使用与子宫内膜癌风险的关系。方法：这是对先前进行的多中心病例对照研究的二次分析，该研究的招募时间为2015年至2021年。病例为组织学确诊为子宫内膜癌的女性。对照组是因其他医疗条件而入住不同病房的妇女，按年龄和入院日期分别与病例相匹配，每个病例有三个对照组。有关避孕措施的数据是由训练有素的人员使用标准化问卷进行访谈收集的。使用条件logistic回归模型计算校正优势比（aORs）和95%置信区间（ci）。结果：378例患者中有115例（30.4%）报告了COCs使用史，1134例对照中有574例（50.6%）报告了COCs使用史。曾经使用COCs的妇女患子宫内膜癌的几率低于从未使用COCs的妇女（aOR 0.60; 95% CI 0.44-0.82）。每增加使用COCs 12个月，子宫内膜癌的几率降低10% （aOR 0.90; 95% CI 0.86-0.93）。前COCs使用者在停药后30年内患子宫内膜癌的几率降低（aOR 0.44; 95% CI 0.25-0.77）。结论：观察到一个明显的趋势，表明随着COCs使用时间的延长，子宫内膜癌的发病率下降。停用COCs后，COCs使用者继续获得对子宫内膜癌的长期保护。
{"title":"Combined Oral Contraceptives and Endometrial Cancer Among Southeast Asian Women: A Secondary Analysis of Multicenter Case–Control Study","authors":"Kuntima Kantawee, Siwanon Rattanakanokchai, Chumnan Kietpeerakool","doi":"10.1111/jog.70176","DOIUrl":"10.1111/jog.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the association of combined oral contraceptives (COCs) use and endometrial cancer risk in Southeast Asian women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a secondary analysis of a previously conducted multicenter case–control study with the recruitment between 2015 and 2021. Cases were women with histologically confirmed diagnoses of endometrial cancer. Controls were women admitted to different wards for other medical conditions and were individually matched to cases by age and admission date, at a ratio of three controls per case. Data regarding contraception practices were collected through interviews conducted by trained personnel using a standardized questionnaire. Conditional logistic regression models were used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 115 (30.4%) out of 378 cases and 574 (50.6%) out of 1134 controls reported a history of COCs use. The odds of endometrial cancer were lower in women who had ever used COCs than those who reported never use (aOR 0.60; 95% CI 0.44–0.82). For every additional 12 months of COCs use, the odds of endometrial cancer decreased by 10% (aOR 0.90; 95% CI 0.86–0.93). Former COCs users had a reduced odds of endometrial cancer for up to 30 years after discontinuation (aOR 0.44; 95% CI 0.25–0.77).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A noticeable trend was observed indicating a decline in the odds of endometrial cancer with increasing duration of COCs use. COCs users continued to receive long-term protection against endometrial cancer after discontinuation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cervical cancer is one of the most common preventable gynecologic cancers, yet it remains a major public health problem worldwide.
Objective
This study was conducted to assess women's attitudes towards early detection of cervical cancer and to determine the factors affecting these attitudes.
Methods
A descriptive cross-sectional study was conducted with 290 women admitted to a university hospital in Turkey between March and May 2025. Data were collected using a Personal Information Form and the Cervical Cancer Early Detection Attitude Scale Attitude Scale for Early Diagnosis of Cervical Cancer.
Results
The mean age of the participants was 40.86 ± 10.80 years. 84.1% of the women had heard of the Pap smear test, and 61.7% had this test. The mean total attitude score was 102.53 ± 10.46, indicating generally positive attitudes.
Conclusion
Women had positive attitudes towards early detection of cervical cancer. Improving access to counseling and screening services is necessary to reduce the burden of cervical cancer.
{"title":"Attitudes Towards Early Diagnosis of Cervical Cancer Among Women Applying to a Health Institution in Turkey","authors":"Serpil Özbaş, Seray Gerey, Şükran Özkahraman Koç","doi":"10.1111/jog.70174","DOIUrl":"10.1111/jog.70174","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cervical cancer is one of the most common preventable gynecologic cancers, yet it remains a major public health problem worldwide.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study was conducted to assess women's attitudes towards early detection of cervical cancer and to determine the factors affecting these attitudes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A descriptive cross-sectional study was conducted with 290 women admitted to a university hospital in Turkey between March and May 2025. Data were collected using a Personal Information Form and the Cervical Cancer Early Detection Attitude Scale Attitude Scale for Early Diagnosis of Cervical Cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of the participants was 40.86 ± 10.80 years. 84.1% of the women had heard of the Pap smear test, and 61.7% had this test. The mean total attitude score was 102.53 ± 10.46, indicating generally positive attitudes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Women had positive attitudes towards early detection of cervical cancer. Improving access to counseling and screening services is necessary to reduce the burden of cervical cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We aimed to assess renal function trends during pregnancy and the early postpartum period and establish trimester-specific reference ranges for maternal renal function parameters in Japan, including comparisons with pregnancies complicated by hypertensive disorders of pregnancy (HDP) and preeclampsia.
Methods
This multicenter retrospective study used data collected from 12 primary maternity care units in Japan between 2011 and 2018. Serum creatinine and blood urea nitrogen (BUN) levels were analyzed from early pregnancy to postpartum Day 7 in 17 460 women with uncomplicated term pregnancies (370/7–416/7 weeks of gestation) and 1460 women with HDP. Additionally, 17 460 non-pregnant women matched for age, body weight, and height were included in the study.
Results
Serum creatinine and BUN levels were lower in women with uncomplicated pregnancies than in non-pregnant women and reached their lowest levels in the second trimester. The 97.5th percentile serum creatinine value was 0.52 mg/dL in the second trimester, compared with 0.82 mg/dL in non-pregnant women. The median serum creatinine levels in uncomplicated pregnancies were approximately 30% lower than those in non-pregnant women. Serum creatinine levels began to normalize during the postpartum period but did not return to baseline non-pregnant status by Day 7. In women with HDP and preeclampsia, serum creatinine levels increased in the late third trimester and peaked on postpartum Day 1; in 7.0% of women with preeclampsia, they exceeded 1.0 mg/dL.
Conclusion
We determined reference ranges for maternal renal markers in a Japanese cohort study. Maternal renal function shows dynamic alterations from the non-pregnant state through pregnancy to the postpartum period.
{"title":"Maternal Renal Function During Pregnancy and the Early Postpartum Period in Normotensive and Hypertensive Pregnancies","authors":"Takafumi Ushida, Satoru Katsuki, Kazuya Fuma, Sho Tano, Seiko Matsuo, Shigeru Yoshida, Mamoru Yamashita, Hiroaki Kajiyama, Tomomi Kotani","doi":"10.1111/jog.70172","DOIUrl":"10.1111/jog.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>We aimed to assess renal function trends during pregnancy and the early postpartum period and establish trimester-specific reference ranges for maternal renal function parameters in Japan, including comparisons with pregnancies complicated by hypertensive disorders of pregnancy (HDP) and preeclampsia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicenter retrospective study used data collected from 12 primary maternity care units in Japan between 2011 and 2018. Serum creatinine and blood urea nitrogen (BUN) levels were analyzed from early pregnancy to postpartum Day 7 in 17 460 women with uncomplicated term pregnancies (37<sup>0/7</sup>–41<sup>6/7</sup> weeks of gestation) and 1460 women with HDP. Additionally, 17 460 non-pregnant women matched for age, body weight, and height were included in the study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Serum creatinine and BUN levels were lower in women with uncomplicated pregnancies than in non-pregnant women and reached their lowest levels in the second trimester. The 97.5th percentile serum creatinine value was 0.52 mg/dL in the second trimester, compared with 0.82 mg/dL in non-pregnant women. The median serum creatinine levels in uncomplicated pregnancies were approximately 30% lower than those in non-pregnant women. Serum creatinine levels began to normalize during the postpartum period but did not return to baseline non-pregnant status by Day 7. In women with HDP and preeclampsia, serum creatinine levels increased in the late third trimester and peaked on postpartum Day 1; in 7.0% of women with preeclampsia, they exceeded 1.0 mg/dL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We determined reference ranges for maternal renal markers in a Japanese cohort study. Maternal renal function shows dynamic alterations from the non-pregnant state through pregnancy to the postpartum period.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12710551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145768283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A trachelectomy is a fertility-preserving surgery that is performed for cervical cancer. Transecting the uterine arteries (UAs) during abdominal radical trachelectomy (ART) or abdominal modified radical trachelectomy (AmRT) has the advantage of simplifying other surgical procedures. However, the effect of UA transection on subsequent pregnancy outcome is unknown. The purpose of this study was to clarify the pregnancy outcomes in post-RT pregnancies in which the UAs were not preserved.
Methods
This was a retrospective cohort study of electronic case records involving pregnant women after ART and AmRT, which were managed at Kyushu University Hospital from January 2008 to July 2024.
Results
Complications that often occur in pregnancies after ART and AmRT, such as antepartum bleeding, premature birth, and preterm premature rupture of membranes, were noted to the same degree after UA-sparing ART. In contrast, abnormalities related to placental attachment, such as placenta previa and adherent placenta, occurred at a high rate after UA transection. Furthermore, compared to pregnancies with normal placentation, pregnancies with abnormal placentation had more blood loss during cesarean section (1150 g vs. 2289 g; p = 0.0004) and required blood transfusion more frequently (5.7% vs. 64.2%; p < 0.0001).
Conclusions
Although ART and AmRT with UA transection may increase the risk of abnormal placentation and bleeding-related complications during cesarean section, UA transection may not increase the risk of major obstetric complications after ART and AmRT. Therefore, UA transection should be considered during ART and AmRT due technical advantages.
目的：气管切除术是一种保留生育能力的手术，适用于宫颈癌。在腹部根治性气管切除术（ART）或腹部改良根治性气管切除术（AmRT）中横切子宫动脉（UAs）具有简化其他手术程序的优点。然而，UA横断对随后妊娠结局的影响尚不清楚。本研究的目的是阐明未保留子宫内膜的rt后妊娠的妊娠结局。方法：对2008年1月至2024年7月在九州大学医院接受ART和AmRT治疗的孕妇电子病历进行回顾性队列研究。结果：ART和AmRT术后妊娠常出现的并发症，如产前出血、早产、早产胎膜早破等，在保ua ART后出现的程度相同。相反，与胎盘附着相关的异常，如前置胎盘和附着胎盘，在UA横断后发生率很高。此外，与正常胎盘妊娠相比，异常胎盘妊娠剖宫产时出血量更多（1150 g对2289 g， p = 0.0004），需要输血次数更多(5.7%对64.2%；p结论：虽然ART和AmRT合并UA横断可能增加剖宫产时胎盘异常和出血相关并发症的风险，但UA横断可能不会增加ART和AmRT后主要产科并发症的风险。因此，由于技术优势，在ART和AmRT中应考虑UA横断。
{"title":"Obstetric Outcome After Trachelectomy for Cervical Cancer Without Uterine Artery Preservation","authors":"Atsuhiko Sakai, Hideaki Yahata, Takako Sugiura, Kazushige Nakahara, Ryo Kiyokoba, Nobutaka Hachisuga, Saki Kido, Ichiro Onoyama, Kazuo Asanoma, Kiyoko Kato","doi":"10.1111/jog.70170","DOIUrl":"10.1111/jog.70170","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>A trachelectomy is a fertility-preserving surgery that is performed for cervical cancer. Transecting the uterine arteries (UAs) during abdominal radical trachelectomy (ART) or abdominal modified radical trachelectomy (AmRT) has the advantage of simplifying other surgical procedures. However, the effect of UA transection on subsequent pregnancy outcome is unknown. The purpose of this study was to clarify the pregnancy outcomes in post-RT pregnancies in which the UAs were not preserved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a retrospective cohort study of electronic case records involving pregnant women after ART and AmRT, which were managed at Kyushu University Hospital from January 2008 to July 2024.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Complications that often occur in pregnancies after ART and AmRT, such as antepartum bleeding, premature birth, and preterm premature rupture of membranes, were noted to the same degree after UA-sparing ART. In contrast, abnormalities related to placental attachment, such as placenta previa and adherent placenta, occurred at a high rate after UA transection. Furthermore, compared to pregnancies with normal placentation, pregnancies with abnormal placentation had more blood loss during cesarean section (1150 g vs. 2289 g; <i>p</i> = 0.0004) and required blood transfusion more frequently (5.7% vs. 64.2%; <i>p</i> < 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although ART and AmRT with UA transection may increase the risk of abnormal placentation and bleeding-related complications during cesarean section, UA transection may not increase the risk of major obstetric complications after ART and AmRT. Therefore, UA transection should be considered during ART and AmRT due technical advantages.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145763116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sule Atalay Mert, Berna Dilbaz, Tugba Agbal, Caner Kose, Yaprak Engin Ustun
Aim
Contrary to popular belief, there is evidence that GTI can occur not only in women who have had their first sexual intercourse but also in married women or those with children during CSI. The aim is to evaluate sexual function with Female Sexual Function Index (FSFI) scores before and after surgical repair of genital tract injury (GTI) that occurred during consensual sexual intercourse (CSI).
Methods
All women aged 18–45 who underwent surgical repair for GTI due to CSI at the Gynecology Clinic between January 2016 and 2020 were included in this retrospective study. Patients were routinely followed up for 1 year after surgery. All patients received counseling for sexual dysfunction following the surgical repair. Only patients with regular sexual activity had their FSFI scores evaluated both before and after surgery.
Results
Out of 45 patients, the mean age was 29.36 ± 8.24 years. Half of the patients (53.1%, 23/45) were between 20 and 40 years old. Among them, 73.3% (33/45) were married, and 72.73% (24/33) had been married for more than 1 year. A significant increase in FSFI scores was observed in all patients after surgery (p < 0.05), along with counseling for sexual dysfunction. However, all patients had preoperative and postoperative FSFI scores below 26.
Conclusion
Low FSFI scores and the improvement observed after sexual counseling highlight its importance. Therefore, clinicians should pay attention to providing sexual counseling alongside GTI repair and ensure they inform married women or those with children about its benefits.
{"title":"Effect of Genital Tract Injury During Consensual Sexual Intercourse on FSFI in Women?","authors":"Sule Atalay Mert, Berna Dilbaz, Tugba Agbal, Caner Kose, Yaprak Engin Ustun","doi":"10.1111/jog.70163","DOIUrl":"10.1111/jog.70163","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Contrary to popular belief, there is evidence that GTI can occur not only in women who have had their first sexual intercourse but also in married women or those with children during CSI. The aim is to evaluate sexual function with Female Sexual Function Index (FSFI) scores before and after surgical repair of genital tract injury (GTI) that occurred during consensual sexual intercourse (CSI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All women aged 18–45 who underwent surgical repair for GTI due to CSI at the Gynecology Clinic between January 2016 and 2020 were included in this retrospective study. Patients were routinely followed up for 1 year after surgery. All patients received counseling for sexual dysfunction following the surgical repair. Only patients with regular sexual activity had their FSFI scores evaluated both before and after surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Out of 45 patients, the mean age was 29.36 ± 8.24 years. Half of the patients (53.1%, 23/45) were between 20 and 40 years old. Among them, 73.3% (33/45) were married, and 72.73% (24/33) had been married for more than 1 year. A significant increase in FSFI scores was observed in all patients after surgery (<i>p</i> < 0.05), along with counseling for sexual dysfunction. However, all patients had preoperative and postoperative FSFI scores below 26.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Low FSFI scores and the improvement observed after sexual counseling highlight its importance. Therefore, clinicians should pay attention to providing sexual counseling alongside GTI repair and ensure they inform married women or those with children about its benefits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"When a Journal Says, “I Am JOGR.”","authors":"Shigeki Matsubara","doi":"10.1111/jog.70173","DOIUrl":"https://doi.org/10.1111/jog.70173","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145824523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huyan Huo, Ning Hu, Yanting Yang, Lin Liu, Fangxiang Mu, Fang Wang
Objective
To identify determinants of biochemical pregnancy (BP) in women with recurrent pregnancy loss (RPL) and develop a predictive nomogram.
Methods
This retrospective study included 621 RPL patients (207 with BP, 414 with clinical pregnancy) at Lanzhou University Second Hospital (2019–2022). Clinical data were compared between groups. Univariate and multivariate logistic regression identified BP predictors, and a nomogram was developed. Model performance was assessed via AUC and calibration curves.
Results
≥ 3 prior losses, assisted reproductive technology (ART), positive antinuclear antibody (ANA), positive lupus anticoagulant (LA), and elevated fasting glucose were independent BP risk factors (OR > 1, p < 0.05), while positive blocking antibody was protective (OR = 0.468, p = 0.029). The nomogram showed an AUC of 0.671 (95% CI: 0.627–0.716), with a well-fitted calibration curve (Hosmer–Lemeshow χ2 = 8.426, p = 0.393).
Conclusion
This study developed a nomogram model incorporating multiple influential factors, thereby providing a robust tool for the clinical assessment of BP risk in RPL patients. Furthermore, it delivers valuable scientific insights to inform subsequent diagnostic approaches, therapeutic strategies, and preventative measures.
目的：探讨复发性妊娠丢失（RPL）患者生化妊娠（BP）的影响因素，并建立预测指标图。方法：对2019-2022年兰州大学第二医院621例RPL患者进行回顾性研究，其中BP患者207例，临床妊娠患者414例。比较两组临床资料。单变量和多变量逻辑回归确定了BP预测因子，并建立了nomogram。通过AUC和校准曲线评估模型性能。结果：既往损失≥3次、辅助生殖技术（ART）、抗核抗体（ANA）阳性、狼疮抗凝剂（LA）阳性、空腹血糖升高是独立的BP危险因素（OR >1, p 2 = 8.426, p = 0.393）。结论：本研究建立了一个包含多种影响因素的nomogram模型，为RPL患者BP风险的临床评估提供了一个可靠的工具。此外，它还提供了有价值的科学见解，为后续的诊断方法、治疗策略和预防措施提供信息。
{"title":"Risk Factors for Biochemical Pregnancy in Women With Recurrent Pregnancy Loss: A Retrospective Cohort Study","authors":"Huyan Huo, Ning Hu, Yanting Yang, Lin Liu, Fangxiang Mu, Fang Wang","doi":"10.1111/jog.70152","DOIUrl":"10.1111/jog.70152","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify determinants of biochemical pregnancy (BP) in women with recurrent pregnancy loss (RPL) and develop a predictive nomogram.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 621 RPL patients (207 with BP, 414 with clinical pregnancy) at Lanzhou University Second Hospital (2019–2022). Clinical data were compared between groups. Univariate and multivariate logistic regression identified BP predictors, and a nomogram was developed. Model performance was assessed via AUC and calibration curves.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>≥ 3 prior losses, assisted reproductive technology (ART), positive antinuclear antibody (ANA), positive lupus anticoagulant (LA), and elevated fasting glucose were independent BP risk factors (OR > 1, <i>p</i> < 0.05), while positive blocking antibody was protective (OR = 0.468, <i>p</i> = 0.029). The nomogram showed an AUC of 0.671 (95% CI: 0.627–0.716), with a well-fitted calibration curve (Hosmer–Lemeshow <i>χ</i><sup>2</sup> = 8.426, <i>p</i> = 0.393).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study developed a nomogram model incorporating multiple influential factors, thereby providing a robust tool for the clinical assessment of BP risk in RPL patients. Furthermore, it delivers valuable scientific insights to inform subsequent diagnostic approaches, therapeutic strategies, and preventative measures.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the effect of satogaeri, a Japanese custom of mothers returning to their parents' home for perinatal and postnatal support, on the health statuses of mothers and infants and the child-rearing support from the surrounding environment.
Methods
We conducted a retrospective cohort study of all pregnancies reported at a city in Tokyo in 2020. Propensity score matching was performed between expectant mothers with the intention to have satogaeri (satogaeri group) and those without (residence group), with age, birth order, place of their parents' residence, and other psychosocial conditions at pregnancy reporting as variables. Follow-up data on mothers and infants from the newborns' 4-month checkup were compared.
Results
We analyzed 1559 expectant mothers, including 399 who had satogaeri. Follow-up data of 270 and 314 in the satogaeri and residence groups, respectively, were compared after matching. Satogaeri was associated with neither infants' 4-month checkup results, including pediatrician assessments (no abnormality: satogaeri group 54% vs. residence group 46%, p = 0.342), nor mothers' health conditions, including perceptions of parenting difficulties (12% vs. 13%, p = 0.749). However, satogaeri was associated with increased support from the mothers' families (65% vs. 55%, p = 0.013) and decreased support from neighbors (0% vs. 3%, p = 0.013). More mothers in the satogaeri group tended to lack knowledge of the city's childcare services (16% vs. 11%, p = 0.052).
Conclusions
Satogaeri was not associated with the health status of mothers and infants at the 4-month checkup. The possible effects of satogaeri suggest the necessity for continuous support for families that select satogaeri.
{"title":"Effect of Postnatal Care Place on Health Statuses of Mothers and Infants and Childrearing Support at 4 Months: A Population-Based Evaluation of Satogaeri, a Japanese Postnatal Care Tradition","authors":"Hayato Yamana, Chikako Honda, Hiroshige Matsumoto, Riho Iwasaki-Motegi, Yuka Sumikawa, Kyoko Yoshioka-Maeda","doi":"10.1111/jog.70171","DOIUrl":"10.1111/jog.70171","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effect of <i>satogaeri</i>, a Japanese custom of mothers returning to their parents' home for perinatal and postnatal support, on the health statuses of mothers and infants and the child-rearing support from the surrounding environment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective cohort study of all pregnancies reported at a city in Tokyo in 2020. Propensity score matching was performed between expectant mothers with the intention to have <i>satogaeri</i> (<i>satogaeri</i> group) and those without (residence group), with age, birth order, place of their parents' residence, and other psychosocial conditions at pregnancy reporting as variables. Follow-up data on mothers and infants from the newborns' 4-month checkup were compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We analyzed 1559 expectant mothers, including 399 who had <i>satogaeri</i>. Follow-up data of 270 and 314 in the <i>satogaeri</i> and residence groups, respectively, were compared after matching. <i>Satogaeri</i> was associated with neither infants' 4-month checkup results, including pediatrician assessments (no abnormality: <i>satogaeri</i> group 54% vs. residence group 46%, <i>p</i> = 0.342), nor mothers' health conditions, including perceptions of parenting difficulties (12% vs. 13%, <i>p</i> = 0.749). However, <i>satogaeri</i> was associated with increased support from the mothers' families (65% vs. 55%, <i>p</i> = 0.013) and decreased support from neighbors (0% vs. 3%, <i>p</i> = 0.013). More mothers in the <i>satogaeri</i> group tended to lack knowledge of the city's childcare services (16% vs. 11%, <i>p</i> = 0.052).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p><i>Satogaeri</i> was not associated with the health status of mothers and infants at the 4-month checkup. The possible effects of <i>satogaeri</i> suggest the necessity for continuous support for families that select <i>satogaeri</i>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to “Fertility-Sparing Trachelectomy With Sentinel Node Mapping in Early-Stage Cervical Cancer: Oncological Safety and Obstetric Outcomes From a Single-Institution Study”","authors":"Yi Xuan, Min Liu, Lei Gao","doi":"10.1111/jog.70165","DOIUrl":"10.1111/jog.70165","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lazar Nejković, Ana Đorđević, Smiljana Donić, Marijana Cimbaljević, Aleksandar Rakić
Perivascular epithelioid cell neoplasms (PEComas) represent a rare category of mesenchymal tumors, with the gastrointestinal and gynecological systems being the most frequently affected sites. A 46-year-old patient was referred to our clinic due to prolonged menstrual bleeding, without additional symptoms. Histopathological analysis of the specimens collected through exploratory curettage demonstrated the presence of uterine PEComa, characterized by positive immunohistochemical markers including HMB-45, TFE3, Cathepsin K, and ER. The patient underwent laparoscopic hysterectomy with bilateral adnexectomy. No recurrence of the disease was observed during the subsequent examinations. This case underscores a common diagnostic pitfall: the absence of a distinct mass on imaging. It highlights that a PEComa can present with only non-specific endometrial thickening, making preoperative diagnosis exceptionally challenging and reliant on histopathology. Laparoscopic surgery in our case provided the patient with quick recovery and a less invasive approach with satisfying results and the absence of recurrent disease during a one-year follow-up period. Future multicenter studies should facilitate a deeper comprehension and undoubtedly lead to a more effective management of a rare and enigmatic condition that is uterine PEComa.
{"title":"Perivascular Epithelioid Cell Neoplasm of the Uterus: A Case Report","authors":"Lazar Nejković, Ana Đorđević, Smiljana Donić, Marijana Cimbaljević, Aleksandar Rakić","doi":"10.1111/jog.70169","DOIUrl":"10.1111/jog.70169","url":null,"abstract":"<div>\u0000 \u0000 <p>Perivascular epithelioid cell neoplasms (PEComas) represent a rare category of mesenchymal tumors, with the gastrointestinal and gynecological systems being the most frequently affected sites. A 46-year-old patient was referred to our clinic due to prolonged menstrual bleeding, without additional symptoms. Histopathological analysis of the specimens collected through exploratory curettage demonstrated the presence of uterine PEComa, characterized by positive immunohistochemical markers including HMB-45, TFE3, Cathepsin K, and ER. The patient underwent laparoscopic hysterectomy with bilateral adnexectomy. No recurrence of the disease was observed during the subsequent examinations. This case underscores a common diagnostic pitfall: the absence of a distinct mass on imaging. It highlights that a PEComa can present with only non-specific endometrial thickening, making preoperative diagnosis exceptionally challenging and reliant on histopathology. Laparoscopic surgery in our case provided the patient with quick recovery and a less invasive approach with satisfying results and the absence of recurrent disease during a one-year follow-up period. Future multicenter studies should facilitate a deeper comprehension and undoubtedly lead to a more effective management of a rare and enigmatic condition that is uterine PEComa.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145742932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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