Journal of Obstetrics and Gynaecology Research最新文献_第4页

Short-Term Indomethacin Use Reduces Preterm Premature Rupture of Membranes After Fetoscopic Laser Surgery for Twin-to-Twin Transfusion Syndrome 短期使用吲哚美辛减少胎镜激光手术治疗双胎输血综合征后胎膜过早破裂。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-12 DOI: 10.1111/jog.70166

Mayu Tachihara, Mayumi Takano, Junya Sakuma, Sumito Nagasaki, Masahiko Nakata

Aims

Preterm labor is a severe problem after fetoscopic laser surgery (FLS), which often requires multiple tocolytic agents. We investigated the utility of indomethacin as a tocolytic agent after FLS.

Methods

This study included monochorionic diamniotic twin pregnancies who underwent FLS for twin-to-twin transfusion syndrome at our hospital from 2015 to 2023. Medical records of all cases were reviewed retrospectively. Since indomethacin has been used routinely since 2020, all cases were divided into the control group (without indomethacin) and IND group (with indomethacin). Indomethacin was administered until 48 h postoperatively. This study was approved by the ethics committee of our hospital, and written informed consent for indomethacin use was obtained from all patients.

Results

Fifty-seven patients were in the IND group and 97 were in the control group. No fetal adverse effects were observed in the IND group. Median gestational age at delivery did not differ between the groups (p = 0.670). pPROM within 14 days after FLS occurred more frequently in the control group (8.2%) than in the IND group (0%) (p = 0.022). The IND group had a shorter median duration of magnesium sulfate use (3 days [2–12]) than the control group (8 days [2–81]) (p < 0.001), and less frequent use of nifedipine (42% vs. 80%, p < 0.001).

Conclusion

The short-term administration of indomethacin was not associated with fetal adverse events, and it may be useful in postoperative management by reducing immediate postoperative pPROM and the need for other tocolytic agents.

目的：早产是胎儿镜激光手术（FLS）后的一个严重问题，通常需要多种抗胎药。我们探讨了吲哚美辛作为FLS后的抗胎药的效用。方法：本研究纳入2015年至2023年在我院因双胎输血综合征接受FLS治疗的单绒毛膜双羊双胎妊娠患者。回顾性分析所有病例的医疗记录。由于自2020年起常规使用吲哚美辛，所有病例分为对照组（不使用吲哚美辛）和IND组（使用吲哚美辛）。术后48 h给予吲哚美辛。本研究经我院伦理委员会批准，所有患者均获得了使用吲哚美辛的书面知情同意书。结果：IND组57例，对照组97例。IND组未见胎儿不良反应。分娩时中位胎龄组间差异无统计学意义（p = 0.670）。FLS后14天内pPROM的发生率在对照组（8.2%）高于IND组（0%）（p = 0.022）。IND组使用硫酸镁的中位时间（3天[2-12]）短于对照组（8天[2-81]）(p结论：短期给药吲哚美辛与胎儿不良事件无关，可能有助于术后治疗，减少术后即刻pPROM和对其他溶栓药物的需求。

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引用次数: 0

Factors Affecting Sleep Quality Among Pregnant Women: A Propensity Score-Matched Analysis 影响孕妇睡眠质量的因素：倾向评分匹配分析。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-11 DOI: 10.1111/jog.70167

Yinxia Zheng, Tian Chen, Reyila Yalihong, Moli Duan

Objective

To assess sleep quality in pregnant women and analyze its influencing factors based on lifestyle, stress levels, physical activity, and other relevant aspects.

Methods

From August 2022 to July 2024 in Urumqi, Xinjiang, a random sampling method was used to assess sleep quality using the pittsburgh sleep quality index (PSQI). General demographic characteristics were collected from 3508 pregnant women. A 1:1 propensity score matching method was used to match participants with good and poor sleep quality, resulting in 1402 pregnant women in each group. The factors influencing sleep quality were analyzed using least absolute shrinkage and selection operator-logistic regression.

Results

Logistic regression analysis revealed that higher monthly income, no history of abortion, and lower exposure to passive smoking before pregnancy were protective factors for sleep quality, while high stress levels and conception via ART (assisted reproductive technology) were identified as risk factors.

Conclusion

Stress and lifestyle habits significantly affect the sleep quality of pregnant women in Urumqi, Xinjiang. Reducing psychological stress through health education and encouraging the development of healthy behavioral habits potentially enhance sleep outcomes. However, due to the regional specificity of the sample, these findings should not be generalized to pregnant women in other regions with different ethnic, cultural, or environmental characteristics.

目的：从生活方式、压力水平、体力活动等方面评价孕妇睡眠质量，并分析其影响因素。方法：2022年8月至2024年7月，在新疆乌鲁木齐市采用随机抽样方法，采用匹兹堡睡眠质量指数（PSQI）评价睡眠质量。收集3508名孕妇的一般人口统计学特征。采用1:1的倾向评分匹配方法，将睡眠质量好的和睡眠质量差的参与者进行匹配，每组1402名孕妇。采用最小绝对收缩法和选择算子logistic回归法对影响睡眠质量的因素进行分析。结果：Logistic回归分析显示，较高的月收入、无流产史和较低的孕前被动吸烟暴露是睡眠质量的保护因素，而高压力水平和通过辅助生殖技术受孕是睡眠质量的危险因素。结论：压力和生活习惯对新疆乌鲁木齐市孕妇睡眠质量有显著影响。通过健康教育和鼓励养成健康的行为习惯来减少心理压力可能会提高睡眠质量。然而，由于样本的区域特异性，这些发现不应推广到其他具有不同种族、文化或环境特征的地区的孕妇。

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引用次数: 0

Partial Trisomy and Partial Monosomy 21 Undetected by NIPT and FISH: A Case Report and Literature Review 未被NIPT和FISH检测到的部分三体和部分单体21:1例报告和文献复习。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-11 DOI: 10.1111/jog.70168

Kota Watanabe, Hironori Takahashi, Risa Narumi, Manabu Ogoyama, Kenji Horie, Hiroyuki Fujiwara

Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which chromosomal microarray analysis (CMA) revealed partial trisomy and partial monosomy of chromosome 21, despite negative results with both NIPT and fluorescence in situ hybridization (FISH). The neonate presented with characteristic phenotypes consistent with Down syndrome (DS). The same chromosomal imbalance was confirmed by postnatal peripheral blood CMA. This case underscores the limitations of NIPT and FISH in detecting structural chromosomal rearrangements and highlights the importance of incorporating CMA when such abnormalities are suspected. Additionally, it emphasizes the critical role of genetic counseling in supporting informed decision-making during the prenatal diagnostic process.

无创产前检测（NIPT）是一种通过分析母体血浆中游离DNA （cfDNA）来检测主要非整倍体的筛查方法。然而，NIPT不能识别细微的染色体畸变。我们报告了一例染色体微阵列分析（CMA）显示21号染色体部分三体和部分单体，尽管NIPT和荧光原位杂交（FISH）结果均为阴性。新生儿表现出与唐氏综合征（DS）一致的特征性表型。出生后外周血CMA证实了同样的染色体失衡。该病例强调了NIPT和FISH在检测染色体结构重排方面的局限性，并强调了当怀疑这种异常时结合CMA的重要性。此外，它强调遗传咨询在产前诊断过程中支持知情决策的关键作用。

引用次数: 0

Correction to “Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients” 更正“甲状腺自身抗体联合CA125提高卵巢子宫内膜异位症的诊断准确性：一项885例患者的回顾性研究”。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-10 DOI: 10.1111/jog.70161

Y. Wang, Z. Qiu, Y. Yao, J. Tan, and X. Che, “Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients,” Journal of Obstetrics and Gynaecology Research 51, no. 10 (2025): e70111, https://doi.org/10.1111/jog.70111.

The authors’ affiliations should have read as follows.

Yufeng Wang^1,2,Zhiruo Qiu²,Yuan Yao³, Jie Tan⁴, Xuan Che²

¹Graduate School of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, ²Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Jiaxing, Zhejiang, China, ³Department of Radiology, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Jiaxing, Zhejiang, China, ⁴Department of Maternal and Child Health, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Jiaxing, Zhejiang, China

We apologize for this error.

王艳，邱之，姚艳，谭建军，陈晓霞，“甲状腺自身抗体与CA125结合提高卵巢子宫内膜异位症的诊断准确性：885例患者的回顾性研究”，中国妇产科杂志，第51期。10 (2025): e70111, https://doi.org/10.1111/jog.70111.The作者的隶属关系应该是这样的。王玉峰1,2，邱志若2，姚媛3，谭杰4，车璇21浙江中医药大学研究生院，浙江杭州；2嘉兴学院附属妇幼医院，嘉兴妇幼医院妇产科，浙江嘉兴；3嘉兴学院附属妇幼医院，嘉兴妇幼医院放射科，浙江嘉兴；4中国浙江省嘉兴市嘉兴市学院附属妇幼医院嘉兴市妇幼保健院妇幼保健科，我们为这个错误道歉。

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引用次数: 0

Role of Phytoestrogens in Endometriosis 植物雌激素在子宫内膜异位症中的作用。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-10 DOI: 10.1111/jog.70158

Mine Sulak, Zekai Halici

Aim

To investigate the therapeutic potential of phytoestrogens in the management of endometriosis and to elucidate their mechanisms of action based on current preclinical and clinical evidence.

Methods

This narrative review evaluates recent studies exploring the biological activity of phytoestrogens—specifically isoflavones, stilbenes, flavonoids, and curcuminoids—in relation to endometriosis pathophysiology. Emphasis was placed on their effects on estrogen signaling, inflammation, angiogenesis, oxidative stress, and apoptosis.

Results

Phytoestrogens exhibit both estrogenic and anti-estrogenic properties depending on their concentration and receptor affinity. Compounds such as resveratrol, genistein, and quercetin have demonstrated the ability to inhibit aromatase activity, downregulate pro-inflammatory cytokines (e.g., TNF-α, IL-6, and COX-2), and suppress vascular endothelial growth factor (VEGF) expression. These actions contribute to reduced lesion growth, decreased inflammation, and enhanced apoptosis in experimental models. Despite these promising findings, clinical data remain limited, and bioavailability concerns, individual variability in metabolism, and potential adverse effects—such as gastrointestinal discomfort or endocrine disruption—must be carefully considered.

Conclusion

Phytoestrogens represent promising adjuncts in the treatment of endometriosis due to their multi-targeted molecular actions and relatively favorable safety profile. However, their clinical application requires further validation through randomized controlled trials. Specialist supervision is recommended to ensure optimal dosing, monitor safety, and evaluate interactions with standard hormonal therapies.

目的：探讨植物雌激素在子宫内膜异位症中的治疗潜力，并根据目前的临床前和临床证据阐明其作用机制。方法：本文综述了近年来植物雌激素（特别是异黄酮、二苯乙烯、类黄酮和姜黄素）在子宫内膜异位症病理生理中的生物学活性。重点研究了它们对雌激素信号、炎症、血管生成、氧化应激和细胞凋亡的影响。结果：植物雌激素表现出雌激素和抗雌激素的特性，这取决于它们的浓度和受体亲和力。白藜芦醇、染料木素和槲皮素等化合物已被证明具有抑制芳香化酶活性、下调促炎细胞因子（如TNF-α、IL-6和COX-2）和抑制血管内皮生长因子（VEGF）表达的能力。在实验模型中，这些作用有助于减少病变生长、减少炎症和增强细胞凋亡。尽管有这些令人鼓舞的发现，临床数据仍然有限，必须仔细考虑生物利用度问题、代谢的个体差异和潜在的不良反应，如胃肠道不适或内分泌干扰。结论：植物雌激素具有多靶点分子作用和较好的安全性，是治疗子宫内膜异位症的理想辅助药物。然而，它们的临床应用需要通过随机对照试验进一步验证。建议专家监督以确保最佳剂量，监测安全性，并评估与标准激素治疗的相互作用。

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引用次数: 0

Prevalence of Perineal Injury After First Vaginal Delivery and Its Association With Pregnancy and Birth Characteristics 首次阴道分娩后会阴损伤的患病率及其与妊娠和出生特征的关系。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-07 DOI: 10.1111/jog.70156

Gabriela Souza de Oliveira Freitas, Marcelle Jaeger Anzolch, Edison Capp, José Geraldo Lopes Ramos, Ana Selma Bertelli Picoloto

Introduction and Hypothesis

The onset of symptoms associated with pelvic floor dysfunctions and injuries after pregnancy and childbirth has been well documented and studied. Avulsion of the levator ani muscle (LAM) is known to be a risk factor for these conditions. This study aimed to evaluate the prevalence of LAM avulsion in patients after their first vaginal delivery, associating this finding with factors related to pregnancy and birth.

Materials and Methods

In a cross-sectional study, we evaluated 100 postpartum women after their first vaginal delivery to identify LAM avulsion using ultrasound imaging and to correlate the presence of this injury with pregnancy and birth-related factors.

Results

Of the 100 primiparous women evaluated, 46% had some degree of avulsion after delivery. Among these, 37% had complete and 63% had partial avulsion. Regarding laterality, 63% of the lesions were unilateral, affecting the muscle asymmetrically, and 37% were bilateral. The weight of the newborn was a significant factor and showed a statistically significant difference between the groups with and without avulsion. Another statistically significant difference observed between the groups was forceps delivery.

Conclusions

The impact of pregnancy and childbirth factors on the pelvic floor muscles is not yet fully elucidated. Identifying these factors is crucial for developing multidisciplinary strategies to prevent such injuries during pregnancy and delivery, thereby reducing their consequences and impact on women's quality of life.

引言和假设：妊娠和分娩后与盆底功能障碍和损伤相关的症状的发作已被充分记录和研究。提肛肌（LAM）撕脱是这些疾病的危险因素。本研究旨在评估首次阴道分娩后LAM撕脱的患病率，并将这一发现与妊娠和分娩相关因素联系起来。材料和方法：在一项横断面研究中，我们评估了100名首次阴道分娩后的产后妇女，利用超声成像识别LAM撕脱，并将这种损伤的存在与妊娠和分娩相关因素联系起来。结果：100例初产妇中，分娩后有不同程度撕脱的占46%。其中37%为完全撕脱，63%为部分撕脱。关于侧侧，63%的病变是单侧的，不对称地影响肌肉，37%是双侧的。新生儿体重是一个重要因素，有撕脱伤组和无撕脱伤组之间有统计学差异。两组间观察到的另一个具有统计学意义的差异是产钳分娩。结论：妊娠和分娩因素对盆底肌肉的影响尚不完全清楚。确定这些因素对于制定多学科战略以预防怀孕和分娩期间的此类伤害至关重要，从而减少其后果和对妇女生活质量的影响。

{"title":"Prevalence of Perineal Injury After First Vaginal Delivery and Its Association With Pregnancy and Birth Characteristics","authors":"Gabriela Souza de Oliveira Freitas, Marcelle Jaeger Anzolch, Edison Capp, José Geraldo Lopes Ramos, Ana Selma Bertelli Picoloto","doi":"10.1111/jog.70156","DOIUrl":"10.1111/jog.70156","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction and Hypothesis</h3>\u0000 \u0000 <p>The onset of symptoms associated with pelvic floor dysfunctions and injuries after pregnancy and childbirth has been well documented and studied. Avulsion of the levator ani muscle (LAM) is known to be a risk factor for these conditions. This study aimed to evaluate the prevalence of LAM avulsion in patients after their first vaginal delivery, associating this finding with factors related to pregnancy and birth.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In a cross-sectional study, we evaluated 100 postpartum women after their first vaginal delivery to identify LAM avulsion using ultrasound imaging and to correlate the presence of this injury with pregnancy and birth-related factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 100 primiparous women evaluated, 46% had some degree of avulsion after delivery. Among these, 37% had complete and 63% had partial avulsion. Regarding laterality, 63% of the lesions were unilateral, affecting the muscle asymmetrically, and 37% were bilateral. The weight of the newborn was a significant factor and showed a statistically significant difference between the groups with and without avulsion. Another statistically significant difference observed between the groups was forceps delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The impact of pregnancy and childbirth factors on the pelvic floor muscles is not yet fully elucidated. Identifying these factors is crucial for developing multidisciplinary strategies to prevent such injuries during pregnancy and delivery, thereby reducing their consequences and impact on women's quality of life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145701087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Smoking, Drinking by Couples and Their Interaction With Pre-Eclampsia: A Prospective Cohort Study in Central China 中国中部地区夫妇吸烟、饮酒与子痫前期的关系及其相互作用：一项前瞻性队列研究。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-05 DOI: 10.1111/jog.70164

Ye Chen, Ridan Lei, Ziye Li, Jiapeng Tang, Qi Zou, Yuan Peng, Manjun Luo, Mengting Sun, Tingting Wang, Jiabi Qin

Aim

Previous studies reported inconsistent results on the effects of maternal smoking and drinking on pre-eclampsia (PE). Furthermore, some studies indicated that the development of PE may also be attributable to unhealthy behaviors from men. Hence, this study aimed to evaluate the association between smoking and drinking by couples and PE in the Asian population.

Methods

A prospective cohort study including 34 104 couples was conducted. Multivariate logistic regression models were used to estimate the odds ratios (ORs) of couples' smoking and drinking behaviors and their interaction. The assignment score method was used to explore the cumulative effect of adverse behavioral exposures to alcohol and tobacco on PE.

Results

Seven hundred eighty-eight-pregnant women (2.31%) were diagnosed with PE. Maternal active smoking 3 months before pregnancy (OR: 2.010, 95% CI: 1.136–3.555), periconceptional active smoking (OR: 1.560, 95% CI: 1.027–2.368), drinking 3 months before pregnancy (OR: 2.101, 95% CI: 1.397–3.158), and periconceptional drinking (OR: 1.829, 95% CI: 1.318–2.539) were positively associated with PE. Spousal smoking was also a risk factor (OR: 1.174, 95% CI: 1.009–1.366). Additionally, there was an antagonistic effect between maternal active smoking and drinking during the periconceptional period. Moreover, with the increase of bad behaviors of couples, the risk of PE also increased to a certain extent.

Conclusions

Maternal active smoking and drinking as well as spousal smoking were risk enhancers of PE in the Asian population. We encourage both couples to actively quit smoking and drinking from the beginning of pregnancy preparation.

目的：以往的研究报道了母亲吸烟和饮酒对子痫前期（PE）影响的不一致的结果。此外，一些研究表明，PE的发展也可能归因于男性的不健康行为。因此，本研究旨在评估亚洲人群中夫妻吸烟和饮酒与PE之间的关系。方法：采用前瞻性队列研究，纳入34104对夫妇。采用多元logistic回归模型估计夫妻吸烟与饮酒行为及其相互作用的比值比（ORs）。采用分配计分法探讨烟酒不良行为暴露对PE的累积效应。结果：788例（2.31%）孕妇诊断为PE。孕妇妊娠前3个月积极吸烟（OR: 2.010, 95% CI: 1.136-3.555）、妊娠期积极吸烟（OR: 1.560, 95% CI: 1.027-2.368）、妊娠前3个月饮酒（OR: 2.101, 95% CI: 1.397-3.158）和妊娠期饮酒（OR: 1.829, 95% CI: 1.318-2.539）与PE呈正相关。配偶吸烟也是一个危险因素（OR: 1.174, 95% CI: 1.009-1.366）。此外，在怀孕期间，产妇积极吸烟和饮酒之间存在拮抗作用。此外，随着夫妻不良行为的增加，PE的风险也在一定程度上增加。结论：在亚洲人群中，母亲主动吸烟和饮酒以及配偶吸烟是PE的风险增强因素。我们鼓励夫妻双方从准备怀孕开始就积极戒烟和戒酒。

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引用次数: 0

Management of Pregnancies With a History of Venous Thromboembolism: Low-Dose Low-Molecular-Weight Heparin and Low-Dose Acetylsalicylic Acid Prophylaxis 有静脉血栓栓塞史的妊娠的管理：低剂量低分子肝素和低剂量乙酰水杨酸预防。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-04 DOI: 10.1111/jog.70160

Mehmet Sinan Beksac, Hanife Guler Donmez

Aim

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE) carries high risk of adverse maternal and fetal outcomes. This Study aimed to evaluate the effectiveness of low-dose low-molecular-weight heparin (LMWH) combined with low-dose acetylsalicylic acid (ASA) prophylaxis in women with a history of VTE.

Methods

A total of 77 pregnant women with a history of VTE (42 DVT, 35 DVT + PE) received daily prophylaxis with low-dose LMWH (enoxaparin, 1 × 2000 anti-Xa IU/0.2 mL) and low-dose ASA (100 mg/day) upon confirmation of pregnancy. Gestational outcomes under prophylaxis were compared with their 256 previous pregnancies.

Results

77.9% of the study cases were with maternal risk factors/comorbidities for thrombosis and obstetric complications. LMWH + ASA significantly reduced adverse gestational outcomes (71.9% vs. 46.8%, p < 0.001), including miscarriage (63.3% to 26%, p < 0.001) and preeclampsia (9%–1.3%, p = 0.022). No thrombotic events occurred.

Conclusions

Prophylactic use of low-dose LMWH and low-dose ASA is effective in the prevention of thrombotic events and improves gestational outcomes in women with a VTE history.

目的：静脉血栓栓塞（VTE），包括深静脉血栓形成（DVT）和肺栓塞（PE）具有高风险的不良母婴结局。本研究旨在评价低剂量低分子量肝素（LMWH）联合低剂量乙酰水杨酸（ASA）预防静脉血栓栓塞（VTE）病史的有效性。方法：77例有静脉血栓栓塞病史（42例DVT， 35例DVT + PE）的孕妇，确认妊娠后给予低剂量低分子肝素（依诺肝素，1 × 2000抗- xa IU/0.2 mL）和低剂量ASA （100 mg/d）每日预防。预防后的妊娠结局与她们之前256次妊娠进行比较。结果：77.9%的研究病例存在孕产妇危险因素/血栓形成和产科并发症的合并症。低分子肝素+ ASA可显著降低不良妊娠结局（71.9% vs. 46.8%, p）结论：预防性使用低剂量低分子肝素和低剂量ASA可有效预防血栓形成事件，改善有静脉血栓栓塞病史妇女的妊娠结局。

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引用次数: 0

Correlation of PD-L1 Expression With Microsatellite Instability and p53 Status in Endometrial Cancer: A Clinicopathological and Molecular Analysis 子宫内膜癌中PD-L1表达与微卫星不稳定性和p53状态的相关性：临床病理和分子分析。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-04 DOI: 10.1111/jog.70162

Marcin Misiek, Janusz Kopczynski, Aleksandra Misiek, Andrzej Wrobel, Tomasz Kluz, Anita Chudecka-Glaz

Aim

This study aimed to evaluate the correlations between programmed death-ligand 1 (PD-L1) expression, the mismatch repair system, and p53 status in endometrial cancer, considering tumor stage.

Methods

A retrospective analysis of clinicopathological and immunohistochemical data was conducted on 254 patients treated at Holy Cross Cancer Centre (Poland). The majority of patients had endometrioid adenocarcinoma (89.8%) and FIGO stage I disease (69.7%).

Results

Positive PD-L1 expression (threshold ≥ 1%) was observed in only 3.9% of cases, while mismatch repair system deficiency and aberrant p53 expression were present in 18.1% and 17.3%, respectively. No significant correlations were found between PD-L1 expression and clinicopathological parameters, repair system status, or p53 (p = 0.328 and p = 0.359, respectively). However, a significant association (p = 0.046) was noted between PD-L1 positivity and the microsatellite-unstable/hypermutated molecular subtype, with 30% of PD-L1 positive tumors exhibiting this subtype compared to 10.2% of PD-L1 negative tumors.

Conclusions

No molecular marker demonstrated a significant association with recurrence risk (p > 0.05), in contrast to the FIGO stage, which showed a significant correlation (p < 0.001). Although PD-L1 expression was rare, it was significantly associated with microsatellite instability, highlighting the potential of molecular classification to identify candidates for immunotherapy. However, the low frequency of PD-L1 positivity and the small sample size warrant caution in interpreting these findings, and further research is needed to confirm the clinical relevance of PD-L1 in endometrial cancer.

目的：本研究旨在评估程序死亡配体1 （programmed death-ligand 1, PD-L1）表达、错配修复系统和p53状态在子宫内膜癌中的相关性，并考虑肿瘤分期。方法：回顾性分析在波兰圣十字癌症中心接受治疗的254例患者的临床病理和免疫组织化学资料。大多数患者为子宫内膜样腺癌（89.8%）和FIGO I期疾病（69.7%）。结果：PD-L1阳性表达（阈值≥1%）仅占3.9%，错配修复系统缺陷和p53异常表达分别占18.1%和17.3%。PD-L1表达与临床病理参数、修复系统状态或p53之间无显著相关性（p = 0.328和p = 0.359）。然而，PD-L1阳性与微卫星不稳定/超突变分子亚型之间存在显著关联（p = 0.046）， 30%的PD-L1阳性肿瘤表现出这种亚型，而PD-L1阴性肿瘤的这一比例为10.2%。结论：与FIGO分期相比，无分子标志物与复发风险有显著相关性（p < 0.05）， FIGO分期有显著相关性（p < 0.05）

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引用次数: 0

Cadherin-18 and Preeclampsia: A Novel Biomarker With Prognostic Value in the Second Trimester? 钙粘蛋白-18与子痫前期：一种具有妊娠中期预后价值的新生物标志物？

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-12-04 DOI: 10.1111/jog.70159

Neset Gumusburun, Sebati Sinan Urkmez, Yesim Civil Urkmez, Sakine Merve Aydin, Bahtiyar Ciftci

Objective

Preeclampsia is an obstetric complication with morbidity and mortality that occurs after the 20th week of pregnancy. Cadherins, which play a role in trophoblast development and placentation, are blamed for the pathogenesis of this disease and our aim was to investigate the potential of cadherin-18 level to predict pre-eclampsia.

Methods

In this retrospective case–control study, serum cadherin-18 levels in the early second trimester of pregnancy (between 15 and 20 weeks of gestation) were compared between pregnant women who developed preeclampsia within a 1-year period and healthy pregnant women.

Results

A total of 170 pregnant women were included in the study; 85 of them were diagnosed with preeclampsia and 85 of them constituted the healthy control group. Of the patients diagnosed with preeclampsia, 40 were classified as early-onset and 45 as late-onset preeclampsia. The mean age was 30.8 years in the preeclampsia group and 28.7 years in the control group. Serum cadherin-18 levels were significantly higher in patients with preeclampsia compared to healthy pregnant women. According to Receiver Operating Characteristic curve analysis, the cut-off value of 1015.9 pg/mL for the diagnosis of preeclampsia had discriminative power with a sensitivity of 57.6% and specificity of 94.1%. In addition, cadherin-18 levels above 1302.5 pg/mL provided 85.0% sensitivity and 98.5% specificity in predicting early-onset preeclampsia.

Conclusion

Cadherin-18 level is associated with preeclampsia and may be used as a potential biomarker in the prediction of this disease.

目的：先兆子痫是一种发病率和死亡率高的产科并发症，发生在妊娠第20周之后。钙粘蛋白，在滋养细胞发育和胎盘中起作用，被认为是这种疾病的发病机制，我们的目的是研究钙粘蛋白-18水平预测子痫前期的潜力。方法：在本回顾性病例对照研究中，比较1年内发生先兆子痫的孕妇与健康孕妇在妊娠中期早期（妊娠15 ~ 20周）血清钙粘蛋白-18水平。结果：共有170名孕妇被纳入研究；其中85例诊断为子痫前期，85例为健康对照组。在诊断为子痫前期的患者中，40例为早发型子痫前期，45例为晚发型子痫前期。先兆子痫组平均年龄30.8岁，对照组平均年龄28.7岁。子痫前期患者血清钙粘蛋白-18水平明显高于健康孕妇。根据受试者工作特征曲线分析，1015.9 pg/mL对先兆子痫的诊断具有鉴别能力，敏感性为57.6%，特异性为94.1%。此外，1302.5 pg/mL以上的cadherin-18水平在预测早发性子痫前期提供了85.0%的敏感性和98.5%的特异性。结论：Cadherin-18水平与先兆子痫相关，可作为预测该病的潜在生物标志物。

{"title":"Cadherin-18 and Preeclampsia: A Novel Biomarker With Prognostic Value in the Second Trimester?","authors":"Neset Gumusburun, Sebati Sinan Urkmez, Yesim Civil Urkmez, Sakine Merve Aydin, Bahtiyar Ciftci","doi":"10.1111/jog.70159","DOIUrl":"10.1111/jog.70159","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Preeclampsia is an obstetric complication with morbidity and mortality that occurs after the 20th week of pregnancy. Cadherins, which play a role in trophoblast development and placentation, are blamed for the pathogenesis of this disease and our aim was to investigate the potential of cadherin-18 level to predict pre-eclampsia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this retrospective case–control study, serum cadherin-18 levels in the early second trimester of pregnancy (between 15 and 20 weeks of gestation) were compared between pregnant women who developed preeclampsia within a 1-year period and healthy pregnant women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 170 pregnant women were included in the study; 85 of them were diagnosed with preeclampsia and 85 of them constituted the healthy control group. Of the patients diagnosed with preeclampsia, 40 were classified as early-onset and 45 as late-onset preeclampsia. The mean age was 30.8 years in the preeclampsia group and 28.7 years in the control group. Serum cadherin-18 levels were significantly higher in patients with preeclampsia compared to healthy pregnant women. According to Receiver Operating Characteristic curve analysis, the cut-off value of 1015.9 pg/mL for the diagnosis of preeclampsia had discriminative power with a sensitivity of 57.6% and specificity of 94.1%. In addition, cadherin-18 levels above 1302.5 pg/mL provided 85.0% sensitivity and 98.5% specificity in predicting early-onset preeclampsia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Cadherin-18 level is associated with preeclampsia and may be used as a potential biomarker in the prediction of this disease.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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