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Origins of obesity in the womb: Fetal adiposity and its determinants. 子宫内肥胖的起源:胎儿脂肪及其决定因素。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-09 DOI: 10.1111/jog.16114
Satoru Ikenoue, Junko Tamai, Keisuke Akita, Toshimitsu Otani, Yoshifumi Kasuga, Mamoru Tanaka

Birth weight is an important predictor of perinatal complications and long-term health outcomes of offspring. Fetal programming influenced by maternal obesity, overnutrition, and hyperglycemia has been proposed as the fuel overload hypothesis. Recent investigations related with fetal body composition have revealed that neonatal adiposity can be predicted by fetal fat mass, and that maternal insulin resistance and serum leptin level are indicators of fetal adiposity. Based on the current evidence, the origins of obesity can partly be traced back into the fetal life. Further clarification of the determinants of fetal fat mass may lead to the clinical interventions and treatment strategies for fetal growth and development. This effort potentially leads to the elucidation of pathological conditions related with long-term health outcomes and the primary prevention of childhood obesity and early onset metabolic syndrome.

出生体重是预测围产期并发症和后代长期健康状况的重要指标。受母体肥胖、营养过剩和高血糖影响的胎儿发育过程被称为 "燃料超载假说"。最近与胎儿身体组成有关的研究发现,新生儿的脂肪含量可通过胎儿的脂肪量预测,而母体的胰岛素抵抗和血清瘦素水平是胎儿脂肪含量的指标。根据目前的证据,肥胖的起源部分可以追溯到胎儿时期。进一步阐明胎儿脂肪量的决定因素,可能会为胎儿的生长发育提供临床干预和治疗策略。这项工作有可能导致阐明与长期健康结果相关的病理条件,并对儿童肥胖症和早发性代谢综合征进行初级预防。
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引用次数: 0
The preventive health management self-efficacy related to preterm labor scale in reproductive-aged women: Validation of Turkish reliability and factor structure. 育龄妇女与早产相关的预防性健康管理自我效能量表:土耳其可靠性和因子结构验证
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-09 DOI: 10.1111/jog.16117
Ebru Cirban-Ekrem, Zeynep Daşıkan, Şenay Ünsal-Atan

Aim: This study aims to test and adapt the Turkish psychometric properties of the preventive health management self-efficacy related to premature labor (PHMSE-PL) scale for women of reproductive age.

Methods: The study follows a methodological approach. The original scale comprises 34 items distributed across 5 subscales and is structured on a five-point Likert scale. The study sample consisted of 351 women aged 19 to 49, all without any physical or mental disabilities, irrespective of marital status or pregnancy status. Exclusion criteria encompassed women engaged in healthcare professions such as medical faculty, nursing, or midwifery, as well as those with a history of preterm birth during pregnancy.

Results: During the validity assessment of the scale, language, content, and construct validity were scrutinized. In the reliability phase, internal consistency and stability over time -analyses were conducted. Following confirmation of language validity, all items achieved a content validity index value exceeding 0.80. Exploratory and confirmatory factor analyses were employed to assess structural validity, revealing that the scale retained its original grouping into five sub-factors. These factors collectively accounted for 81.5% of the variance. The Cronbach's alpha coefficient for the entire scale reached 0.98, indicating high internal consistency. Test-retest analyses yielded a correlation coefficient of 0.99 between overall scale scores, demonstrating excellent consistency between the two measurement measurements.

Conclusions: The PHMSE-PL scale adapted to Turkish culture demonstrated high levels of validity and reliability.

目的:本研究旨在测试和调整土耳其育龄妇女与早产有关的预防性健康管理自我效能量表(PHMSE-PL)的心理测量学特性:方法:本研究采用方法论方法。原始量表由 34 个项目组成,分布在 5 个分量表中,采用李克特五点量表结构。研究样本包括 351 名年龄在 19 岁至 49 岁之间的妇女,她们均无任何身体或精神残疾,不分婚姻状况或怀孕状况。排除标准包括从事医疗保健职业(如医务人员、护士或助产士)的女性,以及在怀孕期间有过早产史的女性:在量表的效度评估过程中,对语言、内容和结构的效度进行了仔细研究。在信度阶段,进行了内部一致性和稳定性分析。在确认了语言效度后,所有项目的内容效度指数都超过了 0.80。在评估结构效度时,采用了探索性和确认性因子分析,结果表明量表保留了原有的五个子因子。这些因子共占方差的 81.5%。整个量表的 Cronbach's alpha 系数达到 0.98,表明内部一致性很高。通过重测分析,量表总分之间的相关系数为 0.99,表明两种测量方法之间具有极好的一致性:结论:适应土耳其文化的 PHMSE-PL 量表具有很高的有效性和可靠性。
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引用次数: 0
Amniotic fluid glucose concentration as a predictor of fetal trisomy 羊水葡萄糖浓度可预测胎儿三体综合征。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-07 DOI: 10.1111/jog.16115
Megumi Konno, Hiroshi Miura, Akira Sato, Akiko Fujishima, Kenichi Makino, Hiromitsu Shirasawa, Kyoko Nomura, Yukihiro Terada

Aim

We aimed to assess the amniotic fluid glucose concentration cut-off as an indicator of fetal chromosomal abnormalities, such as trisomy 13, 18, and 21.

Methods

This prospective observational study included pregnant females who underwent amniocentesis. Participants were divided into two groups on the border of 22 weeks of gestational age (<22 and ≥22-week groups).

Results

In total, 224 pregnant females were included in the analysis. In the <22 week group, 15 females had trisomies 13/18/21 and 174 females had no trisomies. In the ≥22 week group, 18 females had trisomies 13/18/21 and 17 had no trisomies. In each group, there was a difference in amniotic fluid glucose concentration between fetuses with trisomies 13, 18, and 21 and other fetuses with normal karyotype or minor chromosomal abnormalities. In both groups, the amniotic glucose concentration was noticeably lower in trisomies 13/18/21 (p = 0.002 in the <22 week group; p = 0.039 in the ≥22 week group). According to receiver operating characteristic curves, the optimal cut-off point of glucose concentration was 46 mg/dL in the <22 week group (odds ratio 6.55; 95% confidence interval 1.78–24.1) and 24 mg/dL in the ≥22 week group (odds ratio 8.40; 95% confidence interval 1.83–38.6).

Conclusions

Our study suggested that glucose concentration in amniotic fluid is an indicator of trisomy 13, 18, and 21. Amniotic fluid glucose concentration itself does not diagnose fetal trisomy, but this may be helpful in selecting treatment facilities.

目的:我们旨在评估作为胎儿染色体异常(如 13、18 和 21 三体综合征)指标的羊水葡萄糖浓度临界值:这项前瞻性观察研究纳入了接受羊水穿刺术的孕妇。结果:共有 224 名孕妇接受了羊膜腔穿刺术:共有 224 名孕妇参与分析。结论我们的研究表明,羊水中的葡萄糖浓度是 13、18 和 21 三体综合征的指标。羊水葡萄糖浓度本身并不能诊断胎儿三体综合征,但这可能有助于选择治疗机构。
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引用次数: 0
Awareness, attitude, and acceptance of post placental intra uterine contraceptive device (PPIUCD) among women in Jordan 约旦妇女对胎盘后子宫内避孕器(PPIUCD)的认识、态度和接受程度。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-03 DOI: 10.1111/jog.16110
Hasan Rawashdeh, Tamara Alalawne, Bara Abujaber, Noura Alshraiedeh, Shereen Hamadneh

Aim

To assess the awareness, attitude, and acceptance of the Post Placental Intra Uterine Contraceptive Device (PPIUCD) as an immediate long-acting contraceptive method among Jordanian women.

Methods

A cross-sectional observational study was conducted at King Abdulla University Hospital among women attending antenatal clinics after 20 weeks of gestation between January 2020 and May 2021. One thousand and 30 women had completed a structured questionnaire in Arabic.

Results

Only 41.4% of the sample was aware of the PPIUCD. The attitude toward PPIUCD after a brief introduction was 56.3%. Women who had used interval IUCD were 5.82 times more likely to express a positive attitude toward PPIUCD, while postgraduate women were 1.35 times more prone to show the same attitude. Only 34% accepted PPIUCD if offered, whereas the main barrier to acceptance was the false fear of extra complications in 34.5% of the sample. The rate of unintended current pregnancy was 35.8%, where 53.4% were using natural methods.

Conclusions

The rate of awareness of PPIUCD is low among women in Jordan. Antenatal introduction encourages attitude toward PPIUCD.

目的:评估约旦妇女对胎盘后子宫内避孕器(PPIUCD)作为一种长效即时避孕方法的认识、态度和接受程度:2020 年 1 月至 2021 年 5 月期间,在阿卜杜拉国王大学医院对妊娠 20 周后到产前门诊就诊的妇女进行了横断面观察研究。共有 130 名妇女填写了阿拉伯语结构式问卷:结果:只有 41.4% 的样本了解 PPIUCD。经过简单介绍后,56.3%的人对 PPIUCD 持肯定态度。使用过间歇性宫内节育器的妇女对 PPIUCD 持积极态度的几率是普通妇女的 5.82 倍,而研究生妇女持同样态度的几率是普通妇女的 1.35 倍。只有 34% 的样本接受了 PPIUCD,而 34.5% 的样本接受 PPIUCD 的主要障碍是对额外并发症的错误恐惧。目前的意外怀孕率为 35.8%,其中 53.4% 使用自然避孕法:结论:约旦妇女对 PPIUCD 的认知率较低。结论:约旦妇女对 PPIUCD 的知晓率较低,产前介绍可促进对 PPIUCD 的态度。
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引用次数: 0
Transvaginal natural orifice transluminal endoscopic surgery hysterectomy in patients with body mass index >50: An Asian experience 体重指数大于 50 的患者经阴道自然腔道内镜手术切除子宫:亚洲经验。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1111/jog.16105
Wayne Ng, Nicole-Ann Lim, Joella Xiaohong Ang, Yvonne Wan Yu Wong, Ravichandran Nadarajah

We present two cases of patients with body mass index (BMI) >50 undergoing transvaginal natural orifice transluminal endoscopic surgery (vNOTES) hysterectomy for gynecological indications. Case 1 involves a 52-year-old woman with post-menopausal bleeding and suspicion of ovarian torsion, while case 2 describes a patient with newly diagnosed endometrial adenocarcinoma. Both cases highlight the feasibility and challenges of vNOTES in this patient population. To date, this is the first paper to describe the use of vNOTES in patients of Asian ethnicity, with BMI >50.

我们介绍了两例体重指数(BMI)大于 50 的患者因妇科疾病接受经阴道自然腔道内窥镜手术(vNOTES)切除子宫的病例。病例1涉及一名绝经后出血并怀疑卵巢扭转的52岁女性,而病例2则描述了一名新诊断出子宫内膜腺癌的患者。这两个病例都突显了 vNOTES 在这类患者中的可行性和挑战性。迄今为止,这是第一篇描述在体重指数大于 50 的亚裔患者中使用 vNOTES 的论文。
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引用次数: 0
A randomized controlled trial on the comparison of two doses of carbetocin with oxytocin for the prevention of postpartum hemorrhage (concert trial) 比较两种剂量的卡贝缩宫素和催产素以预防产后出血的随机对照试验(协同试验)。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-02 DOI: 10.1111/jog.16097
Rasheedat O. Balogun, Olatunji O. Lawal, Yusuf O. Bello, Tolulope M. Odedele, Imran O. Morhason-Bello, Adesina Oladokun

Aim

To compare the effectiveness of 50 and 100 μg of carbetocin with 10 IU of oxytocin for the prevention of postpartum hemorrhage (PPH).

Methods

This was a triple-blind, non-inferiority trial involving pregnant women recruited at term. We compared two doses of carbetocin (50 and 100 μg) with 10 IU of oxytocin administered as uterotonic agent after vaginal or cesarean delivery. Uterine contractility was assessed at 2- and 5-min after uterotonic administration. The association between adequate uterine tone and PPH with the patients' characteristics were examined using the chi-square test. Effect of the drugs on the odds of developing PPH was examined using logistics regressions. All analyses were conducted using STATA (StataCorp L.L.C.) with a significance level set at 0.05.

Results

In total, 324 women (50 μg carbetocin group-111, 100 μg carbetocin group-106, and oxytocin group-107) participated in the study. There was a significantly higher proportion of women with adequate uterine tone in those that had 100 μg carbetocin relative to 50 μg and 10 IU oxytocin at 5 min (p < 0.001). Patients who received oxytocin had a higher average blood loss than women that had either 50 or 100 μg carbetocin (p = 0.128). There was a significant difference in the need for additional uterotonic, with a higher proportion of participants among those who received 10 IU of oxytocin (p < 0.001).

Conclusion

Patients that had 100 μg of carbetocin had a better adequate uterine tone at the fifth minute compared to those who had 50 μg and 10 IU of oxytocin. Generally, carbetocin use was less likely associated with risk of PPH and use of additional intervention.

目的:比较 50 和 100 μg 卡贝缩宫素与 10 IU 催产素在预防产后出血(PPH)方面的效果:这是一项三盲、非劣效试验,参与者包括足月孕妇。我们比较了两种剂量的卡贝缩宫素(50 和 100 μg)和 10 IU 的催产素,前者作为阴道分娩或剖宫产后的子宫收缩剂。在使用子宫收缩剂后 2 分钟和 5 分钟评估子宫收缩力。采用卡方检验法检验了充足的子宫张力和 PPH 与患者特征之间的关系。使用物流回归分析了药物对 PPH 发生几率的影响。所有分析均使用 STATA(StataCorp L.L.C.)进行,显著性水平设定为 0.05:共有 324 名妇女(50 μg 卡贝缩宫素组-111、100 μg 卡贝缩宫素组-106 和催产素组-107)参与了研究。与 50 μg 和 10 IU 催产素相比,在 5 分钟内使用 100 μg 卡贝缩宫素的妇女中,子宫张力充足的比例明显更高(P 结论:100 μg 卡贝缩宫素组比 50 μg 和 10 IU 催产素组的子宫张力高):与使用 50 微克和 10 IU 催产素的患者相比,使用 100 微克卡贝缩宫素的患者在第 5 分钟时的子宫张力更充足。一般来说,使用卡贝缩宫素与发生 PPH 的风险和使用额外干预的可能性较小。
{"title":"A randomized controlled trial on the comparison of two doses of carbetocin with oxytocin for the prevention of postpartum hemorrhage (concert trial)","authors":"Rasheedat O. Balogun,&nbsp;Olatunji O. Lawal,&nbsp;Yusuf O. Bello,&nbsp;Tolulope M. Odedele,&nbsp;Imran O. Morhason-Bello,&nbsp;Adesina Oladokun","doi":"10.1111/jog.16097","DOIUrl":"10.1111/jog.16097","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To compare the effectiveness of 50 and 100 μg of carbetocin with 10 IU of oxytocin for the prevention of postpartum hemorrhage (PPH).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a triple-blind, non-inferiority trial involving pregnant women recruited at term. We compared two doses of carbetocin (50 and 100 μg) with 10 IU of oxytocin administered as uterotonic agent after vaginal or cesarean delivery. Uterine contractility was assessed at 2- and 5-min after uterotonic administration. The association between adequate uterine tone and PPH with the patients' characteristics were examined using the chi-square test. Effect of the drugs on the odds of developing PPH was examined using logistics regressions. All analyses were conducted using STATA (StataCorp L.L.C.) with a significance level set at 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 324 women (50 μg carbetocin group-111, 100 μg carbetocin group-106, and oxytocin group-107) participated in the study. There was a significantly higher proportion of women with adequate uterine tone in those that had 100 μg carbetocin relative to 50 μg and 10 IU oxytocin at 5 min (<i>p</i> &lt; 0.001). Patients who received oxytocin had a higher average blood loss than women that had either 50 or 100 μg carbetocin (<i>p</i> = 0.128). There was a significant difference in the need for additional uterotonic, with a higher proportion of participants among those who received 10 IU of oxytocin (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients that had 100 μg of carbetocin had a better adequate uterine tone at the fifth minute compared to those who had 50 μg and 10 IU of oxytocin. Generally, carbetocin use was less likely associated with risk of PPH and use of additional intervention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":null,"pages":null},"PeriodicalIF":1.6,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is single-port laparoscopy or vaginal natural orifice transluminal endoscopic surgery the better option for salpingo-oophorectomy? 在输卵管切除术中,单孔腹腔镜手术还是阴道自然孔腔内镜手术是更好的选择?
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1111/jog.16112
Varol Gülseren, Kemal Güngördük, Berican Şahin Uyar, İsa Aykut Özdemir

Aim

To compare postoperative pain and recovery in patients undergoing oophorectomy with single-port laparoscopic surgery (SPLS) versus vaginal natural orifice transluminal endoscopic surgery (vNOTES).

Method

Patients who underwent salpingo-oophorectomy with SPLS or vNOTES between 2016 and 2023 were analyzed retrospectively. Oophorectomy was performed based on the presence of an adnexal mass or breast cancer susceptibility gene mutation.

Results

Fifty-two patients underwent oophorectomy with SPLS and 35 underwent vNOTES. Although the mean mass size was slightly larger in the SPLS group than in the vNOTES group (8.0 ± 4.1 vs. 6.8 ± 3.3 cm), the difference was not significant. There was no difference in operating times between SPLS and vNOTES. The mean visual analog scale and faces pain scale scores 2 and 6 h postoperatively were lower in the vNOTES group. The mean quality of recovery-40 (QoR-40) score was higher in the vNOTES group (156 ± 14 vs. 148 ± 11; p = 0.009). This analysis identified vNOTES as an independent predictor of a high QoR-40 score.

Conclusion

The vNOTES group experienced less pain during the early postoperative period than the SPLS group. Although the operating and removal times were similar, the port setup time was longer for the vNOTES group.

目的:比较单孔腹腔镜手术(SPLS)与阴道自然孔腔内镜手术(vNOTES)输卵管切除术患者的术后疼痛和恢复情况:方法:对2016年至2023年间接受单孔腹腔镜手术或vNOTES输卵管切除术的患者进行回顾性分析。结果:52 名患者接受了卵巢切除术:52名患者接受了SPLS输卵管切除术,35名患者接受了vNOTES输卵管切除术。虽然 SPLS 组的平均肿块大小略大于 vNOTES 组(8.0 ± 4.1 对 6.8 ± 3.3 厘米),但差异并不显著。SPLS 和 vNOTES 的手术时间没有差异。vNOTES组术后2小时和6小时的平均视觉模拟量表和面孔疼痛量表评分较低。vNOTES组的平均恢复质量-40(QoR-40)评分更高(156 ± 14 vs. 148 ± 11; p = 0.009)。这项分析确定 vNOTES 是 QoR-40 高分的独立预测因素:结论:与 SPLS 组相比,vNOTES 组术后早期疼痛较轻。虽然手术和移除时间相似,但 vNOTES 组的端口安装时间更长。
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引用次数: 0
Effect of hemoglobin, albumin, lymphocyte, and platelet score on prognosis in intermediate-risk endometrial cancer according to molecular-based classification 基于分子分类的血红蛋白、白蛋白、淋巴细胞和血小板评分对中危子宫内膜癌预后的影响。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1111/jog.16103
Cem Yagmur Ozdemir, Nayif Cicekli, Betül Ahat, Bahar Marangoz, Suleyman Konus, Rıza Dur, Dagistan Tolga Arioz

Objective

The aim of this study is to compare the relationship between molecular classification and HALP score in endometrial cancer (EC).

Methods

Patients who were operated with the diagnosis of EC 2014 and 2024 were included in our study. 150 patients were included in the study. We divided the patients into three groups in terms of molecular classification; group 1 was the patients with POLE mutation, group 2 was the patients with MMRd and NSMP (intermediate prognosis), and group 3 was the patients with p53 mutation. Group 2 participants were divided into two groups, a low HALP score group and a high HALP score group, according to the HALP score cut-off value.

Results

Using the value with the highest Youden's index (0.306) as a basis, it was demonstrated that the HALP score with a cut-off value of 33.735 has a sensitivity of 61.86% and a specificity of 68.75% in intermediate-risk EC. The 5-year overall survival (OS) was found to be 75.4% in intermediate-risk EC patients with low HALP scores and 91.5% in intermediate-risk EC patients with high HALP scores (p = 0.008). The 5-year progression-free survival (PFS) was found to be 86% in intermediate-risk EC patients with low HALP scores and 94.4% in intermediate-risk EC patients with high HALP scores (p = 0.089). MMR deficiency and NSMP have been considered intermediate-risk groups for endometrial cancer and are a heterogeneous group. Although the use of the HALP score to reduce this heterogeneity is successful in predicting OS, it is not sufficient for PFS.

目的:本研究旨在比较子宫内膜癌(EC)分子分类与 HALP 评分之间的关系:本研究旨在比较子宫内膜癌(EC)分子分类与 HALP 评分之间的关系:研究纳入了 2014 年和 2024 年确诊为子宫内膜癌的手术患者。研究共纳入 150 例患者。根据分子分类,我们将患者分为三组:第一组为 POLE 突变患者,第二组为 MMRd 和 NSMP(中等预后)患者,第三组为 p53 突变患者。根据HALP评分的临界值,第2组参与者被分为两组,即低HALP评分组和高HALP评分组:结果:以尤登指数(Youden's index)最高的值(0.306)为基础,结果表明,HALP评分临界值为33.735时,对中危EC的敏感性为61.86%,特异性为68.75%。研究发现,HALP评分低的中危EC患者的5年总生存率(OS)为75.4%,HALP评分高的中危EC患者的5年总生存率(OS)为91.5%(P = 0.008)。HALP评分低的中危EC患者的5年无进展生存期(PFS)为86%,HALP评分高的中危EC患者的5年无进展生存期(PFS)为94.4%(P = 0.089)。MMR 缺乏症和 NSMP 被认为是子宫内膜癌的中危人群,是一个异质性群体。虽然使用 HALP 评分减少这种异质性能成功预测 OS,但不足以预测 PFS。
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引用次数: 0
Endometrial cancer and endometrial changes in transgender men: Insights from Japanese individuals on testosterone 变性男性的子宫内膜癌和子宫内膜变化:从使用睾酮的日本人身上获得的启示。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1111/jog.16099
Mariko Nakahara, Hiroshi Yoshida, Aiko Sakamoto, Takeshi Taguchi, Masaya Uno, Tomoyasu Kato, Mitsuya Ishikawa

Aim

Endometrial changes in Japanese transgender men (TGM) on testosterone use remain elucidated. This study aims to present TGM with endometrial cancer and insights from a literature review of similar cases. Furthermore, we investigated the correlation between endometrial cancer and severe obesity in TGM who underwent gender-affirming surgery.

Methods

Between July 2020 and April 2023, two groups were assessed: 2 TGM with endometrial cancer and 43 TGM without cancer who underwent gender-affirming surgery. A literature review for TGM with endometrial cancer was conducted. Clinical data were retrospectively collected, and histopathological evaluation of female genital organs was performed.

Results

Two TGM with endometrial cancer and an additional four similar cases were identified through a literature search. These TGM had severe obesity (body mass index [BMI] ≥30 kg/m2) and long-term testosterone use, indicating a possible link between endometrial cancer and these factors. Subsequently, we investigated the 43 TGM without cancer. We revealed 30% with obesity (BMI ≥25), only three cases of severe obesity (BMI ≥30), and a significant correlation between testosterone use duration and BMI in TGM without cancer. Histological examination revealed focal proliferative endometrium in 51% of cases and polycystic ovarian changes in 77%.

Conclusions

Our observations suggest a potential link between severe obesity, prolonged testosterone use, and endometrial cancer in transgender men. Histological changes in the female genital tract highlighted frequent focal proliferative endometrium, even under testosterone therapy. Further research should focus on larger, multi-institutional studies to confirm these findings and establish endometrial cancer screening for Japanese TGM.

目的:使用睾酮的日本变性男性(TGM)的子宫内膜变化仍未得到阐明。本研究旨在介绍患有子宫内膜癌的变性人的情况,以及对类似病例的文献综述。此外,我们还调查了接受性别确认手术的 TGM 中子宫内膜癌与严重肥胖之间的相关性:在 2020 年 7 月至 2023 年 4 月期间,我们对两组人进行了评估:2 名患有子宫内膜癌的 TGM 和 43 名未患子宫内膜癌但接受了性别确认手术的 TGM。对患有子宫内膜癌的 TGM 进行了文献回顾。对临床数据进行了回顾性收集,并对女性生殖器官进行了组织病理学评估:结果:通过文献检索发现了两名患有子宫内膜癌的 TGM 和另外四名类似病例。这些TGM都有严重肥胖(体重指数[BMI]≥30 kg/m2)和长期使用睾酮,这表明子宫内膜癌可能与这些因素有关。随后,我们对 43 名未患癌症的 TGM 进行了调查。我们发现 30% 的人肥胖(体重指数≥25),只有 3 例重度肥胖(体重指数≥30),而且在未患癌症的 TGM 中,睾酮使用时间与体重指数之间存在显著相关性。组织学检查显示,51%的病例存在局灶性增生性子宫内膜,77%的病例存在多囊卵巢病变:我们的观察结果表明,变性男性严重肥胖、长期使用睾酮与子宫内膜癌之间存在潜在联系。女性生殖道的组织学变化突出表明,即使在接受睾酮治疗的情况下,子宫内膜也经常出现灶性增生。进一步的研究应侧重于更大规模的多机构研究,以证实这些发现,并为日本变性人建立子宫内膜癌筛查机制。
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引用次数: 0
RETRACTION: Oncologic, Fertility, and Obstetric Outcomes With MPA Therapy in Women with Endometrial Cancer and Atypical Endometrial Hyperplasia RETRACTION:子宫内膜癌和非典型子宫内膜增生妇女接受 MPA 治疗后的肿瘤学、生育能力和产科结果。
IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2024-10-01 DOI: 10.1111/jog.16113

RETRACTION: A. Takeda, Y. Yamamoto, K. Tamura, H. Aoki, H. Noguchi, S. Minato, S. Kamada, R. Arakaki, T. Kaji, and T. Iwasa, “ Oncologic, Fertility, and Obstetric Outcomes With MPA Therapy in Women with Endometrial Cancer and Atypical Endometrial Hyperplasia,” The Journal of Obstetrics and Gynaecology Research 50, no. 4 (2024): 633638, https://doi.org/10.1111/jog.15872.

The above article, published online on 28 December 2023 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors; the journal Editor-in-Chief, Hiroaki Kajiyama; and John Wiley & Sons, Australia, Ltd. The retraction has been agreed upon following an investigation into concerns raised by a third party, which revealed major conceptual overlap and significant primary data redundancy with a previously published article by an overlapping group of authors. Such publishing practice is against the journal's policy and Wiley's Best Practice Guidelines on Research Integrity and Publishing Ethics.

撤回:A. Takeda , Y. Yamamoto , K. Tamura , H. Aoki , H. Noguchi , S. Minato , S. Kamada , R. Arakaki , T. Kaji , and T. Iwasa , "Oncologic, Fertility, and Obstetric Outcomes With MPA Therapy in Women with Endometrial Cancer and Atypical Endometrial Hyperplasia," The Journal of Obstetrics and Gynaecology Research 50, no.4 (2024):633-638, https://doi.org/10.1111/jog.15872.上述文章于 2023 年 12 月 28 日在线发表于 Wiley Online Library (wileyonlinelibrary.com),经作者、期刊主编 Hiroaki Kajiyama 和 John Wiley & Sons, Australia, Ltd.三方协商后已撤回。在对第三方提出的问题进行调查后,发现该文章与一组作者先前发表的文章在概念上有重大重叠,原始数据也有大量冗余,因此同意撤稿。这种出版做法违反了期刊政策和 Wiley 的《研究诚信与出版道德最佳实践指南》。
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Journal of Obstetrics and Gynaecology Research
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