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When a Journal Says, “I Am JOGR.” 当日记说:“我是JOGR。”
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-15 DOI: 10.1111/jog.70173
Shigeki Matsubara
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引用次数: 0
Risk Factors for Biochemical Pregnancy in Women With Recurrent Pregnancy Loss: A Retrospective Cohort Study 复发性妊娠丢失妇女生化妊娠的危险因素:一项回顾性队列研究。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-14 DOI: 10.1111/jog.70152
Huyan Huo, Ning Hu, Yanting Yang, Lin Liu, Fangxiang Mu, Fang Wang

Objective

To identify determinants of biochemical pregnancy (BP) in women with recurrent pregnancy loss (RPL) and develop a predictive nomogram.

Methods

This retrospective study included 621 RPL patients (207 with BP, 414 with clinical pregnancy) at Lanzhou University Second Hospital (2019–2022). Clinical data were compared between groups. Univariate and multivariate logistic regression identified BP predictors, and a nomogram was developed. Model performance was assessed via AUC and calibration curves.

Results

≥ 3 prior losses, assisted reproductive technology (ART), positive antinuclear antibody (ANA), positive lupus anticoagulant (LA), and elevated fasting glucose were independent BP risk factors (OR > 1, p < 0.05), while positive blocking antibody was protective (OR = 0.468, p = 0.029). The nomogram showed an AUC of 0.671 (95% CI: 0.627–0.716), with a well-fitted calibration curve (Hosmer–Lemeshow χ2 = 8.426, p = 0.393).

Conclusion

This study developed a nomogram model incorporating multiple influential factors, thereby providing a robust tool for the clinical assessment of BP risk in RPL patients. Furthermore, it delivers valuable scientific insights to inform subsequent diagnostic approaches, therapeutic strategies, and preventative measures.

目的:探讨复发性妊娠丢失(RPL)患者生化妊娠(BP)的影响因素,并建立预测指标图。方法:对2019-2022年兰州大学第二医院621例RPL患者进行回顾性研究,其中BP患者207例,临床妊娠患者414例。比较两组临床资料。单变量和多变量逻辑回归确定了BP预测因子,并建立了nomogram。通过AUC和校准曲线评估模型性能。结果:既往损失≥3次、辅助生殖技术(ART)、抗核抗体(ANA)阳性、狼疮抗凝剂(LA)阳性、空腹血糖升高是独立的BP危险因素(OR >1, p 2 = 8.426, p = 0.393)。结论:本研究建立了一个包含多种影响因素的nomogram模型,为RPL患者BP风险的临床评估提供了一个可靠的工具。此外,它还提供了有价值的科学见解,为后续的诊断方法、治疗策略和预防措施提供信息。
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引用次数: 0
Effect of Postnatal Care Place on Health Statuses of Mothers and Infants and Childrearing Support at 4 Months: A Population-Based Evaluation of Satogaeri, a Japanese Postnatal Care Tradition 产后护理场所对4个月时母婴健康状况和育儿支持的影响:日本产后护理传统Satogaeri的人群评价
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-14 DOI: 10.1111/jog.70171
Hayato Yamana, Chikako Honda, Hiroshige Matsumoto, Riho Iwasaki-Motegi, Yuka Sumikawa, Kyoko Yoshioka-Maeda

Aim

To evaluate the effect of satogaeri, a Japanese custom of mothers returning to their parents' home for perinatal and postnatal support, on the health statuses of mothers and infants and the child-rearing support from the surrounding environment.

Methods

We conducted a retrospective cohort study of all pregnancies reported at a city in Tokyo in 2020. Propensity score matching was performed between expectant mothers with the intention to have satogaeri (satogaeri group) and those without (residence group), with age, birth order, place of their parents' residence, and other psychosocial conditions at pregnancy reporting as variables. Follow-up data on mothers and infants from the newborns' 4-month checkup were compared.

Results

We analyzed 1559 expectant mothers, including 399 who had satogaeri. Follow-up data of 270 and 314 in the satogaeri and residence groups, respectively, were compared after matching. Satogaeri was associated with neither infants' 4-month checkup results, including pediatrician assessments (no abnormality: satogaeri group 54% vs. residence group 46%, p = 0.342), nor mothers' health conditions, including perceptions of parenting difficulties (12% vs. 13%, p = 0.749). However, satogaeri was associated with increased support from the mothers' families (65% vs. 55%, p = 0.013) and decreased support from neighbors (0% vs. 3%, p = 0.013). More mothers in the satogaeri group tended to lack knowledge of the city's childcare services (16% vs. 11%, p = 0.052).

Conclusions

Satogaeri was not associated with the health status of mothers and infants at the 4-month checkup. The possible effects of satogaeri suggest the necessity for continuous support for families that select satogaeri.

目的:评价日本母亲回娘家接受围产期和产后支持的习俗satogaeri对母婴健康状况和周围环境的育儿支持的影响。方法:我们对2020年东京某城市报告的所有妊娠进行了回顾性队列研究。在有意使用萨托加利的孕妇(萨托加利组)和不打算使用萨托加利的孕妇(居住地组)之间进行倾向评分匹配,将年龄、出生顺序、父母居住地和其他怀孕时的社会心理状况作为变量进行报告。对新生儿4个月检查时母亲和婴儿的随访数据进行比较。结果:我们分析了1559名孕妇,其中399名患有satogaeri。在配对后,分别比较了270名和314名萨托加里组和居住地组的随访数据。Satogaeri与婴儿4个月的检查结果无关,包括儿科医生的评估(无异常:Satogaeri组54%对居住组46%,p = 0.342),也与母亲的健康状况无关,包括对育儿困难的看法(12%对13%,p = 0.749)。然而,satogaeri与母亲家庭的支持增加(65%对55%,p = 0.013)和邻居的支持减少(0%对3%,p = 0.013)有关。satogaeri组中更多的母亲往往缺乏对城市托儿服务的了解(16%对11%,p = 0.052)。结论:Satogaeri与母亲和婴儿在4个月体检时的健康状况无关。萨托加利可能产生的影响表明,有必要为选择萨托加利的家庭提供持续的支持。
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引用次数: 0
Letter to “Fertility-Sparing Trachelectomy With Sentinel Node Mapping in Early-Stage Cervical Cancer: Oncological Safety and Obstetric Outcomes From a Single-Institution Study” 致“早期宫颈癌保留生育能力的前哨淋巴结切除术:来自单一机构研究的肿瘤安全性和产科结果”的信。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-14 DOI: 10.1111/jog.70165
Yi Xuan, Min Liu, Lei Gao
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引用次数: 0
Perivascular Epithelioid Cell Neoplasm of the Uterus: A Case Report 子宫血管周围上皮样细胞瘤1例报告。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-12 DOI: 10.1111/jog.70169
Lazar Nejković, Ana Đorđević, Smiljana Donić, Marijana Cimbaljević, Aleksandar Rakić

Perivascular epithelioid cell neoplasms (PEComas) represent a rare category of mesenchymal tumors, with the gastrointestinal and gynecological systems being the most frequently affected sites. A 46-year-old patient was referred to our clinic due to prolonged menstrual bleeding, without additional symptoms. Histopathological analysis of the specimens collected through exploratory curettage demonstrated the presence of uterine PEComa, characterized by positive immunohistochemical markers including HMB-45, TFE3, Cathepsin K, and ER. The patient underwent laparoscopic hysterectomy with bilateral adnexectomy. No recurrence of the disease was observed during the subsequent examinations. This case underscores a common diagnostic pitfall: the absence of a distinct mass on imaging. It highlights that a PEComa can present with only non-specific endometrial thickening, making preoperative diagnosis exceptionally challenging and reliant on histopathology. Laparoscopic surgery in our case provided the patient with quick recovery and a less invasive approach with satisfying results and the absence of recurrent disease during a one-year follow-up period. Future multicenter studies should facilitate a deeper comprehension and undoubtedly lead to a more effective management of a rare and enigmatic condition that is uterine PEComa.

血管周围上皮样细胞肿瘤(PEComas)是一类罕见的间充质肿瘤,胃肠道和妇科系统是最常见的受累部位。患者46岁,因经期出血时间延长,无其他症状。通过探查性刮取标本的组织病理学分析显示存在子宫PEComa,其特征是免疫组织化学标志物包括HMB-45, TFE3, Cathepsin K和ER阳性。患者行腹腔镜子宫切除术并双侧附件切除术。在随后的检查中未观察到疾病复发。本病例强调了一个常见的诊断缺陷:影像学上没有明显的肿块。它强调PEComa可以只呈现非特异性子宫内膜增厚,使得术前诊断非常具有挑战性和依赖于组织病理学。在我们的病例中,腹腔镜手术为患者提供了快速恢复和微创的方法,结果令人满意,并且在一年的随访期间没有复发疾病。未来的多中心研究应促进对子宫PEComa这一罕见而神秘的疾病的更深入的理解和更有效的治疗。
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引用次数: 0
Short-Term Indomethacin Use Reduces Preterm Premature Rupture of Membranes After Fetoscopic Laser Surgery for Twin-to-Twin Transfusion Syndrome 短期使用吲哚美辛减少胎镜激光手术治疗双胎输血综合征后胎膜过早破裂。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-12 DOI: 10.1111/jog.70166
Mayu Tachihara, Mayumi Takano, Junya Sakuma, Sumito Nagasaki, Masahiko Nakata

Aims

Preterm labor is a severe problem after fetoscopic laser surgery (FLS), which often requires multiple tocolytic agents. We investigated the utility of indomethacin as a tocolytic agent after FLS.

Methods

This study included monochorionic diamniotic twin pregnancies who underwent FLS for twin-to-twin transfusion syndrome at our hospital from 2015 to 2023. Medical records of all cases were reviewed retrospectively. Since indomethacin has been used routinely since 2020, all cases were divided into the control group (without indomethacin) and IND group (with indomethacin). Indomethacin was administered until 48 h postoperatively. This study was approved by the ethics committee of our hospital, and written informed consent for indomethacin use was obtained from all patients.

Results

Fifty-seven patients were in the IND group and 97 were in the control group. No fetal adverse effects were observed in the IND group. Median gestational age at delivery did not differ between the groups (p = 0.670). pPROM within 14 days after FLS occurred more frequently in the control group (8.2%) than in the IND group (0%) (p = 0.022). The IND group had a shorter median duration of magnesium sulfate use (3 days [2–12]) than the control group (8 days [2–81]) (p < 0.001), and less frequent use of nifedipine (42% vs. 80%, p < 0.001).

Conclusion

The short-term administration of indomethacin was not associated with fetal adverse events, and it may be useful in postoperative management by reducing immediate postoperative pPROM and the need for other tocolytic agents.

目的:早产是胎儿镜激光手术(FLS)后的一个严重问题,通常需要多种抗胎药。我们探讨了吲哚美辛作为FLS后的抗胎药的效用。方法:本研究纳入2015年至2023年在我院因双胎输血综合征接受FLS治疗的单绒毛膜双羊双胎妊娠患者。回顾性分析所有病例的医疗记录。由于自2020年起常规使用吲哚美辛,所有病例分为对照组(不使用吲哚美辛)和IND组(使用吲哚美辛)。术后48 h给予吲哚美辛。本研究经我院伦理委员会批准,所有患者均获得了使用吲哚美辛的书面知情同意书。结果:IND组57例,对照组97例。IND组未见胎儿不良反应。分娩时中位胎龄组间差异无统计学意义(p = 0.670)。FLS后14天内pPROM的发生率在对照组(8.2%)高于IND组(0%)(p = 0.022)。IND组使用硫酸镁的中位时间(3天[2-12])短于对照组(8天[2-81])(p结论:短期给药吲哚美辛与胎儿不良事件无关,可能有助于术后治疗,减少术后即刻pPROM和对其他溶栓药物的需求。
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引用次数: 0
Factors Affecting Sleep Quality Among Pregnant Women: A Propensity Score-Matched Analysis 影响孕妇睡眠质量的因素:倾向评分匹配分析。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-11 DOI: 10.1111/jog.70167
Yinxia Zheng, Tian Chen, Reyila Yalihong, Moli Duan

Objective

To assess sleep quality in pregnant women and analyze its influencing factors based on lifestyle, stress levels, physical activity, and other relevant aspects.

Methods

From August 2022 to July 2024 in Urumqi, Xinjiang, a random sampling method was used to assess sleep quality using the pittsburgh sleep quality index (PSQI). General demographic characteristics were collected from 3508 pregnant women. A 1:1 propensity score matching method was used to match participants with good and poor sleep quality, resulting in 1402 pregnant women in each group. The factors influencing sleep quality were analyzed using least absolute shrinkage and selection operator-logistic regression.

Results

Logistic regression analysis revealed that higher monthly income, no history of abortion, and lower exposure to passive smoking before pregnancy were protective factors for sleep quality, while high stress levels and conception via ART (assisted reproductive technology) were identified as risk factors.

Conclusion

Stress and lifestyle habits significantly affect the sleep quality of pregnant women in Urumqi, Xinjiang. Reducing psychological stress through health education and encouraging the development of healthy behavioral habits potentially enhance sleep outcomes. However, due to the regional specificity of the sample, these findings should not be generalized to pregnant women in other regions with different ethnic, cultural, or environmental characteristics.

目的:从生活方式、压力水平、体力活动等方面评价孕妇睡眠质量,并分析其影响因素。方法:2022年8月至2024年7月,在新疆乌鲁木齐市采用随机抽样方法,采用匹兹堡睡眠质量指数(PSQI)评价睡眠质量。收集3508名孕妇的一般人口统计学特征。采用1:1的倾向评分匹配方法,将睡眠质量好的和睡眠质量差的参与者进行匹配,每组1402名孕妇。采用最小绝对收缩法和选择算子logistic回归法对影响睡眠质量的因素进行分析。结果:Logistic回归分析显示,较高的月收入、无流产史和较低的孕前被动吸烟暴露是睡眠质量的保护因素,而高压力水平和通过辅助生殖技术受孕是睡眠质量的危险因素。结论:压力和生活习惯对新疆乌鲁木齐市孕妇睡眠质量有显著影响。通过健康教育和鼓励养成健康的行为习惯来减少心理压力可能会提高睡眠质量。然而,由于样本的区域特异性,这些发现不应推广到其他具有不同种族、文化或环境特征的地区的孕妇。
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引用次数: 0
Partial Trisomy and Partial Monosomy 21 Undetected by NIPT and FISH: A Case Report and Literature Review 未被NIPT和FISH检测到的部分三体和部分单体21:1例报告和文献复习。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-11 DOI: 10.1111/jog.70168
Kota Watanabe, Hironori Takahashi, Risa Narumi, Manabu Ogoyama, Kenji Horie, Hiroyuki Fujiwara

Non-invasive prenatal testing (NIPT) is a screening method that analyzes cell-free DNA (cfDNA) in maternal plasma to detect major aneuploidies. However, NIPT can fail to identify subtle chromosomal aberrations. We report a case in which chromosomal microarray analysis (CMA) revealed partial trisomy and partial monosomy of chromosome 21, despite negative results with both NIPT and fluorescence in situ hybridization (FISH). The neonate presented with characteristic phenotypes consistent with Down syndrome (DS). The same chromosomal imbalance was confirmed by postnatal peripheral blood CMA. This case underscores the limitations of NIPT and FISH in detecting structural chromosomal rearrangements and highlights the importance of incorporating CMA when such abnormalities are suspected. Additionally, it emphasizes the critical role of genetic counseling in supporting informed decision-making during the prenatal diagnostic process.

无创产前检测(NIPT)是一种通过分析母体血浆中游离DNA (cfDNA)来检测主要非整倍体的筛查方法。然而,NIPT不能识别细微的染色体畸变。我们报告了一例染色体微阵列分析(CMA)显示21号染色体部分三体和部分单体,尽管NIPT和荧光原位杂交(FISH)结果均为阴性。新生儿表现出与唐氏综合征(DS)一致的特征性表型。出生后外周血CMA证实了同样的染色体失衡。该病例强调了NIPT和FISH在检测染色体结构重排方面的局限性,并强调了当怀疑这种异常时结合CMA的重要性。此外,它强调遗传咨询在产前诊断过程中支持知情决策的关键作用。
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引用次数: 0
Correction to “Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients” 更正“甲状腺自身抗体联合CA125提高卵巢子宫内膜异位症的诊断准确性:一项885例患者的回顾性研究”。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-10 DOI: 10.1111/jog.70161

Y. Wang, Z. Qiu, Y. Yao, J. Tan, and X. Che, “Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients,” Journal of Obstetrics and Gynaecology Research 51, no. 10 (2025): e70111, https://doi.org/10.1111/jog.70111.

The authors’ affiliations should have read as follows.

Yufeng Wang1,2,Zhiruo Qiu2,Yuan Yao3, Jie Tan4, Xuan Che2

1Graduate School of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China, 2Department of Obstetrics and Gynecology, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Jiaxing, Zhejiang, China, 3Department of Radiology, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Jiaxing, Zhejiang, China, 4Department of Maternal and Child Health, Jiaxing Maternity and Child Health Care Hospital, Affiliated Women and Children Hospital, Jiaxing University, Jiaxing, Zhejiang, China

We apologize for this error.

王艳,邱之,姚艳,谭建军,陈晓霞,“甲状腺自身抗体与CA125结合提高卵巢子宫内膜异位症的诊断准确性:885例患者的回顾性研究”,中国妇产科杂志,第51期。10 (2025): e70111, https://doi.org/10.1111/jog.70111.The作者的隶属关系应该是这样的。王玉峰1,2,邱志若2,姚媛3,谭杰4,车璇21浙江中医药大学研究生院,浙江杭州;2嘉兴学院附属妇幼医院,嘉兴妇幼医院妇产科,浙江嘉兴;3嘉兴学院附属妇幼医院,嘉兴妇幼医院放射科,浙江嘉兴;4中国浙江省嘉兴市嘉兴市学院附属妇幼医院嘉兴市妇幼保健院妇幼保健科,我们为这个错误道歉。
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引用次数: 0
Role of Phytoestrogens in Endometriosis 植物雌激素在子宫内膜异位症中的作用。
IF 1.5 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Pub Date : 2025-12-10 DOI: 10.1111/jog.70158
Mine Sulak, Zekai Halici

Aim

To investigate the therapeutic potential of phytoestrogens in the management of endometriosis and to elucidate their mechanisms of action based on current preclinical and clinical evidence.

Methods

This narrative review evaluates recent studies exploring the biological activity of phytoestrogens—specifically isoflavones, stilbenes, flavonoids, and curcuminoids—in relation to endometriosis pathophysiology. Emphasis was placed on their effects on estrogen signaling, inflammation, angiogenesis, oxidative stress, and apoptosis.

Results

Phytoestrogens exhibit both estrogenic and anti-estrogenic properties depending on their concentration and receptor affinity. Compounds such as resveratrol, genistein, and quercetin have demonstrated the ability to inhibit aromatase activity, downregulate pro-inflammatory cytokines (e.g., TNF-α, IL-6, and COX-2), and suppress vascular endothelial growth factor (VEGF) expression. These actions contribute to reduced lesion growth, decreased inflammation, and enhanced apoptosis in experimental models. Despite these promising findings, clinical data remain limited, and bioavailability concerns, individual variability in metabolism, and potential adverse effects—such as gastrointestinal discomfort or endocrine disruption—must be carefully considered.

Conclusion

Phytoestrogens represent promising adjuncts in the treatment of endometriosis due to their multi-targeted molecular actions and relatively favorable safety profile. However, their clinical application requires further validation through randomized controlled trials. Specialist supervision is recommended to ensure optimal dosing, monitor safety, and evaluate interactions with standard hormonal therapies.

目的:探讨植物雌激素在子宫内膜异位症中的治疗潜力,并根据目前的临床前和临床证据阐明其作用机制。方法:本文综述了近年来植物雌激素(特别是异黄酮、二苯乙烯、类黄酮和姜黄素)在子宫内膜异位症病理生理中的生物学活性。重点研究了它们对雌激素信号、炎症、血管生成、氧化应激和细胞凋亡的影响。结果:植物雌激素表现出雌激素和抗雌激素的特性,这取决于它们的浓度和受体亲和力。白藜芦醇、染料木素和槲皮素等化合物已被证明具有抑制芳香化酶活性、下调促炎细胞因子(如TNF-α、IL-6和COX-2)和抑制血管内皮生长因子(VEGF)表达的能力。在实验模型中,这些作用有助于减少病变生长、减少炎症和增强细胞凋亡。尽管有这些令人鼓舞的发现,临床数据仍然有限,必须仔细考虑生物利用度问题、代谢的个体差异和潜在的不良反应,如胃肠道不适或内分泌干扰。结论:植物雌激素具有多靶点分子作用和较好的安全性,是治疗子宫内膜异位症的理想辅助药物。然而,它们的临床应用需要通过随机对照试验进一步验证。建议专家监督以确保最佳剂量,监测安全性,并评估与标准激素治疗的相互作用。
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引用次数: 0
期刊
Journal of Obstetrics and Gynaecology Research
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