Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Correlation between the 5-tier fetal heart rate pattern classification at delivery and Apgar scores","authors":"Mariko Watanabe,&nbsp;Norikazu Watanabe,&nbsp;Mika Fukase,&nbsp;Keiko Yamanouchi,&nbsp;Satoru Nagase","doi":"10.1111/jog.16199","DOIUrl":"10.1111/jog.16199","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>In Japan, the fetal heart rate pattern on cardiotocography is usually categorized into five levels for intrapartum management; however, studies on the 5-tier cardiotocography classification are limited. This study aimed to determine the correlation between 5-tier cardiotocography levels at delivery, neonatal Apgar scores and perinatal prognosis using a perinatal registry database.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study used the 2018 Perinatal Registry Database of the Japan Society of Obstetrics and Gynecology. Apgar scores and perinatal prognosis were compared between patients with Japan Society of Obstetrics and Gynecology intrapartum cardiotocography levels 1–2, and levels 3–5.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 240 987 cases were registered, with 114 201 full-term deliveries comprising 84 703 vaginal and 29 498 cesarean deliveries. For vaginal delivery cases, the crude odds ratios of 1-min Apgar score ≤3 for levels 3 (odds ratio: 1.7, 95% confidence interval: 1.4–2.0, <i>p</i> &lt; 0.0001), levels 4 (odds ratio: 5.9, 95% confidence interval: 5.1–6.9, <i>p</i> &lt; 0.0001), and levels 5 (odds ratio: 49.2, 95% confidence interval: 37.5–64.5, <i>p</i> &lt; 0.0001) were significantly higher than those for levels 1–2 (odds ratio: 1.0). Moreover, the crude odds ratios of 5-min Apgar score ≤ 3 for levels 4 (odds ratio: 4.8, confidence interval: 2.7–8.7, <i>p</i> &lt; 0.0001), and levels 5 (odds ratio: 71.1, confidence interval: 32.6–155.1, <i>p</i> &lt; 0.0001) were significantly higher than those for levels 1–2 (odds ratio: 1.0). Similarly, in cases of cesarean delivery, it showed a similar trend to case of vaginal delivery cases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The 5-tier cardiotocography classification can predict severe neonatal asphyxia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tadalafil suppresses LPS-induced inflammation and improves pregnancy outcomes in a pregnant mouse model","authors":"Kento Yoshikawa-Terada,&nbsp;Erina Takayama,&nbsp;Midori Uemura,&nbsp;Kuniaki Toriyabe,&nbsp;Ryota Tachibana,&nbsp;Hideaki Yajima,&nbsp;Tomoaki Ikeda,&nbsp;Eiji Kondo,&nbsp;Hiroki Takeuchi","doi":"10.1111/jog.16196","DOIUrl":"https://doi.org/10.1111/jog.16196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study investigated the efficacy of tadalafil in reducing inflammation and improving pregnancy outcomes in an lipopolysaccharide (LPS)-induced mouse model of perinatal complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pregnant C57BL/6J mice were divided into three groups: control (C), LPS (L), and LPS + tadalafil (LT). The LT group received tadalafil from 10 days post-coitum (dpc), and LPS was administered intraperitoneally to the L and LT groups at 11 dpc. Mice were sacrificed 2 h post-injection for inflammatory marker analysis, with plasma and placentas collected. Remaining mice were sacrificed at 14 dpc to assess miscarriage and FGR. Placental damage was scored, cytokine levels measured by ELISA, and TNFα and NF-κB expression examined via immunohistochemistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fetal weight was significantly lower in the L and LT groups compared to the C group, with the LT group showing a significant increase compared to the L group. Absorption rates were significantly higher in the L group compared to the C and LT groups. At 14 dpc, placental necrosis scores were significantly higher in the L and LT groups than in the C group, while the LT group showed a significant decrease compared to the L group. Plasma inflammatory cytokine levels (TNF-α, IL-1β, IL-6) were significantly elevated following LPS administration but reduced with tadalafil treatment. Additionally, TNF-α expression and NF-κB activity in the placenta were significantly higher in the L group compared to the C and LT groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tadalafil reduced inflammation and improved pregnancy outcomes, suggesting its potential for managing inflammation-related perinatal complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Humans-written versus ChatGPT-generated case reports","authors":"Shunsuke Koga,&nbsp;Wei Du","doi":"10.1111/jog.16195","DOIUrl":"10.1111/jog.16195","url":null,"abstract":"","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women","authors":"Ahmed M. Maged,&nbsp;Nour A. El-Goly,&nbsp;Doaa Turki,&nbsp;Nehal Bassiouny,&nbsp;Nihal El-Demiry","doi":"10.1111/jog.16194","DOIUrl":"10.1111/jog.16194","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate the efficacy and safety of Carbetocin compared to oxytocin in prevention of postpartum hemorrhage (PPH) after low-risk cesarean delivery (CD).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Search Strategy&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Screening of Medline, Web Of Science, Scopus, Google scholar, and clinical trials registry till January 2024 using the key words related to carbetocin, blood loss, PPH, Cesarean section and their MeSH terms was done.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Selection Criteria&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study included all RCTs conducted on women with low risk for developing PPH after CD and compared the administration of carbetocin to oxytocin without any language limitation. These studies compared carbetocin to oxytocin alone or oxytocin combined with misoprostol. The review included all doses and routes of carbetocin and oxytocin administration.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Data Collection and Analysis&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The extracted data included study settings, the participants' size and characteristics, intervention details of both the study and control groups especially data about the dose route and timing of drug administration, the outcome parameters and trial registration details The reported outcomes included the requirement of additional uterotonic agents or blood transfusion, the difference between preoperative and postoperative hemoglobin, the occurrence of PPH, blood loss and drug adverse effects.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Main Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Seventeen studies including 3667 participants were included. The need for additional uterotonic agents was evaluated in 14 studies with 3154 participants and revealed an OR of 0.53 with 95% CI of 0.39 and 0.72 (&lt;i&gt;p&lt;/i&gt; &lt; 0.001, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; 41%). The incidence of PPH was reported in 11 studies with 2228 participants and revealed an Odd ratio of 1.08 with 95%CI of [0.81, 1.44] (&lt;i&gt;p&lt;/i&gt; = 0.61, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; 0%). The hemoglobin drop after the operation was evaluated in 3 studies with 1240 participants and revealed an MD of −0.08 with 95% CI of −0.10 and − 0.06 (&lt;i&gt;p&lt;/i&gt; &lt; 0.001, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; 0%). The need for blood transfusion was evaluated in 9 studies with 1936 participants and revealed an OR of 0.57 with 95% CI of 0.34 and 0.97 (&lt;i&gt;p&lt;/i&gt; = 0.04, &lt;i&gt;I&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt; 0%).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Carbetocin administration during CD in women with low risk for PPH is associated with less need for additional uterotonic agents (moderate evidence), less ne","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of transient hyperthyroidism induced by placental site trophoblastic tumor","authors":"Sumire Ishii,&nbsp;Takashi Hirayama,&nbsp;Harumi Saeki,&nbsp;Kazunari Fujino,&nbsp;Yasuhisa Terao,&nbsp;Atsuo Itakura","doi":"10.1111/jog.16193","DOIUrl":"10.1111/jog.16193","url":null,"abstract":"<p>We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6 months after delivery. Endometrial histology suggested PSTT. Serum human chorionic gonadotropin (hCG) was 117 mIU/mL and serum estradiol (E2) were 51 pg/mL. She reported increased appetite, sweating, fatigue, and 7-kg weight loss within 3 months. Blood samples showed a thyroid-stimulating hormone (TSH) level &lt;0.01 μIU/mL, FT3: 24.3 pg/mL, FT4: 5.3 ng/mL. The patient was diagnosed with hyperthyroidism. After thyroid function normalized, laparoscopic hysterectomy and bilateral salpingectomy were performed. Two years postsurgery, there was no recurrence, and thyroid function improved. The hCG produced from gestational trophoblastic disease has stronger TSH activity than that from gestational trophoblasts. However, in PSTT, the E2 level, which increases thyroid-binding proteins and suppresses elevated thyroid hormone levels, is low and may induce hyperthyroidism. In cases of suspected PSTT, thyroid function should be evaluated when hyperthyroid symptoms are present.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anthropometric measurements as predictors of nutritional status in black South African women during pregnancy","authors":"Christen R. Erasmus,&nbsp;Niren R. Maharaj,&nbsp;Anil A. Chuturgoon","doi":"10.1111/jog.16184","DOIUrl":"10.1111/jog.16184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nutritional risk assessment is an essential component of primary health care screening, especially for pregnant women. The aim of this study was to investigate the relationship between maternal body mass index (BMI) and maternal anthropometric measurements in black South African pregnant women, both with and without human immunodeficiency virus (HIV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A cross-sectional observational study design was used. Two hundred black South African pregnant women were recruited of which 90 were HIV-infected and 110 were HIV-uninfected. The anthropometric measurements assessed included mid-upper arm circumference (MUAC), tricep skinfold (TSF), subscapular skinfold (SSF), mid-arm muscle circumference (MAMC), wrist circumference (WC), frame size, and BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Maternal age was significantly associated with changes in maternal anthropometric measurements. Maternal BMI was significantly correlated with other maternal anthropometric measurements including MUAC, TSF, SSF, MAMC, WC, and frame size. The anthropometric measurements that were found to be accurate for assessing obesity in pregnancy included TSF (≥20.75 mm), SSF (≥21.75 mm), MAMC (≥25.23 cm), and WC (≥16.25 cm). Additionally, SSF (≥15.75 mm) and MAMC (≥23.35 cm) could be used to assess for overweight nutritional status. Lastly, frame size could be used to assess for underweight (≥10.05) and normal (≥9.95) nutritional status. No significant anthropometric differences were observed between the HIV-infected pregnant women and the HIV-uninfected pregnant women in this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surrogate anthropometric measurements offer a simple solution for assessing nutritional status in pregnant women. MUAC was the most accurate method for identifying overweight and obesity. Furthermore, maternal HIV status did not affect the anthropometric measurements.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and influencing factors for surgical site infections after cesarean section in China: A systematic review and meta-analysis","authors":"Li Guo,&nbsp;Shujuan Huang,&nbsp;Hongmei Sui,&nbsp;Weichao Li","doi":"10.1111/jog.16172","DOIUrl":"10.1111/jog.16172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to estimate the overall incidence of surgical site infections (SSIs) after cesarean section (CS) and the influencing factors in the Chinese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study searched all relevant literature in English and Chinese search databases (English search bases: PubMed, Embase, Cochrane Library, Web of Science; Chinese search bases: China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database) up to March 19, 2024, according to the search strategy. A random/fixed effects model was decided on the basis of the <i>I</i>² statistic assessing the magnitude of study heterogeneity, and publication bias was assessed using the Begg's test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the selection, a final selection of 25 articles was involved. The estimate of post-CS SSIs in China was 2.4% (95%CI: 0.019, 0.029). Age ≥30 years (WMD: 3.8), pre-pregnancy body mass index (BMI) ≥25 kg/m² (WMD: 1.8), obesity (odds ratio [OR]: 3.0), vaginal cleanliness 3–4 (OR: 4.2), anemia (OR: 1.4), premature rupture of membranes (OR: 2.6), diabetes mellitus (OR: 2.7), National Nosocomial Infections Surveillance System 1–3 (OR: 5.6), emergency surgery (OR: 2.3), trial of labor (OR: 2.9), duration of surgery ≥60 min (OR: 2.0), and intraoperative blood loss &gt;500 mL (OR: 3.5) were the risk factors for post-CS SSIs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The rate of post-CS SSIs estimated was 2.4% in China. Both maternal conditions and surgical factors can potentially increase the risk of post-CS SSIs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab","authors":"Shintaro Yanazume,&nbsp;Yusuke Kobayashi,&nbsp;Yukari Kirita,&nbsp;Ikumi Kitazono,&nbsp;Chikako Nagata,&nbsp;Ayumi Kozai,&nbsp;Akihide Tanimoto,&nbsp;Hiroaki Kobayashi","doi":"10.1111/jog.16182","DOIUrl":"10.1111/jog.16182","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib/pembrolizumab (LEN/PEM). The utility of certain inflammatory biomarkers in endometrial liquid-based cytology (LBC) or peripheral blood samples, such as neutrophil counts, lymphocyte counts, and neutrophil-to-lymphocyte ratio (NLR) were explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 25 patients with advanced or recurrent endometrial cancer who had received LEN/PEM between August 2018 and March 2024. Predictors for overall response (OR), disease control, and progression-free survival, based on neutrophil/lymphocyte counts, NLR scores of the endometrial LBC prior to initial treatment, and peripheral blood prior to initial treatment and prior to LEM/PEM treatment were compared using a receiver operating characteristic curve. Significant predictors were evaluated using the log-rank test, and multivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Although neutrophil counts and NLR score in endometrial LBC prior to initial treatment were better effective predictors for OR, the most accurate predictor of a progression-free status was NLR score in peripheral blood prior to LEM/PEM (0.722, 95% CI: 0.45–0.99, sensitivity: 57.1%, specificity: 94.4%). In peripheral blood prior to LEN/PEM, the lower NLR (NLR &lt;5.39) group had a significantly longer PFS than the higher NLR (5.39 ≤ NLR) group (<i>p</i> = 0.023, median survival: 13.5 vs. 3.0 months), and tended to be independently correlated with PFS (hazard ratio = 2.571; 95% CI = 0.857–7.719; <i>p</i> = 0.092).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Inflammatory biomarkers in endometrial LBC failed to predict the efficacy of LEN/PEM, while peripheral blood NLR score sampled prior to LEN/PEM potentially could be a significant predictor.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between relaxin-2 levels in serum and mode of conception in twin gestations: A prospective cohort study","authors":"Angela Silvano,&nbsp;Oumaima Ammar,&nbsp;Astrid Parenti,&nbsp;Noemi Strambi,&nbsp;Viola Seravalli,&nbsp;Daniele Bani,&nbsp;Mariarosaria Di Tommaso","doi":"10.1111/jog.16190","DOIUrl":"10.1111/jog.16190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Relaxin is a peptide hormone commonly associated with pregnancy when it is thought to play a role in modulating various physiological processes to optimize maternal–fetal adaptation. In twin pregnancies these adaptive requirements are higher than in singleton pregnancies, therefore it is important to understand how circulating relaxin behaves in such conditions. This prospective cohort study aims to determine the serum relaxin-2 levels throughout gestation in twin pregnancies and to investigate its association with the mode of conception.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Blood samples were collected during each trimester of gestation from 26 women with twin pregnancies obtained through spontaneous conception (SC, <i>n</i> = 18) or assisted reproductive technologies, specifically through intracytoplasmic sperm injection (ART, <i>n</i> = 8). Serum relaxin-2 levels were measured by a highly sensitive ELISA method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results indicated that serum relaxin-2 level peaks in the first trimester (491.05 ± 207.41 pg/mL), then decreases in the second trimester (446.27 ± 180.4 pg/mL; <i>p</i> &lt; 0.057) and in the third trimester (422.19 ± 194.30 pg/mL; <i>p</i> &lt; 0.025). Interestingly, the serum relaxin-2 level was higher in the spontaneous conception group with respect to the assisted reproductive technologies group (<i>p</i> &lt; 0.001), when measured at each trimester of gestation. In addition, the multivariate regression analysis showed that only the assisted reproductive technologies had a significant impact on serum levels of relaxin-2 (<i>p</i> &lt; 0.001), and no significant association was found with other women's clinical and demographic characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings extend the current knowledge about the pattern of circulating relaxin-2 throughout gestation in twin pregnancies, providing a sensitive measurement of serum relaxin-2 levels and a description of its putative physiological roles in humans.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are all vulvar masses Bartholin cysts? A series of cases","authors":"Gizem Boz İzceyhan,&nbsp;Eralp Bulutlar","doi":"10.1111/jog.16186","DOIUrl":"10.1111/jog.16186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>While vulvar masses are not prevalent in society, they are one of the reasons for complaints that arise during visits to gynecology outpatient clinics. An excision is typically necessary for both the purpose of diagnosing and treating the condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We documented three exceptional instances with distinct histopathological diagnoses and varying presentations, as well as a consecutive series of five patients, including one Bartholin abscess and one labia major abscess.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the compilation of this article, we intended to show that vulvar masses can manifest in various forms. It is important not to overlook pathologies other than Bartholin cysts and abscesses, which are commonly encountered reasons for admission to gynecology clinics. Additionally, it is crucial to always consider the possibility of malignant pathologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Clinicians' expertise and understanding of vulvar masses are comparatively inferior to their knowledge of other gynecological disorders. This case series presents the uncommon vulva masses that we found in our clinic.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}