To determine whether ChatGPT generates a manuscript with a “human touch” with appropriate inputs, and if yes, what's the difference between human writing versus ChatGPT writing. This is because the presence or absence of human touch may characterize human writing.
Methods
A descriptive study. The first author wrote a Disagreement Letter (Letter 1). Then, disagreement points and “human touch” were provided as input into ChatGPT-4 and tasked with generating a Letter (Letter 2). The authors, seven experienced researchers, and ChatGPT evaluated the readability of Letters 1 and 2.
Results
The authors, researchers, and ChatGPT, all reached the same conclusions: the human-written Letter 1 and the ChatGPT-generated Letter 2 had similar readability and similarly involved human touch. Some researchers and ChatGPT recognized slight differences in formal or informal and personal or nonpersonal tones between them, which they considered may not affect paper acceptance.
Conclusions
Human touch is not humans' exclusive possession. The distinction between the human writing versus ChatGPT writing is considered to be present not in the output (manuscript) but in the process of writing, that is, the presence or absence of a joy of writing. Artificial intelligence should aid in enhancing, or at the very least, not impede the human joy. This discussion deserves ongoing exploration.
{"title":"What's the difference between human-written manuscripts versus ChatGPT-generated manuscripts involving “human touch”?","authors":"Shigeki Matsubara, Daisuke Matsubara","doi":"10.1111/jog.16226","DOIUrl":"https://doi.org/10.1111/jog.16226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine whether ChatGPT generates a manuscript with a “human touch” with appropriate inputs, and if yes, what's the difference between human writing versus ChatGPT writing. This is because the presence or absence of human touch may characterize human writing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A descriptive study. The first author wrote a Disagreement Letter (Letter 1). Then, disagreement points and “human touch” were provided as input into ChatGPT-4 and tasked with generating a Letter (Letter 2). The authors, seven experienced researchers, and ChatGPT evaluated the readability of Letters 1 and 2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The authors, researchers, and ChatGPT, all reached the same conclusions: the human-written Letter 1 and the ChatGPT-generated Letter 2 had similar readability and similarly involved human touch. Some researchers and ChatGPT recognized slight differences in formal or informal and personal or nonpersonal tones between them, which they considered may not affect paper acceptance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Human touch is not humans' exclusive possession. The distinction between the human writing versus ChatGPT writing is considered to be present not in the output (manuscript) but in the process of writing, that is, the presence or absence of a joy of writing. Artificial intelligence should aid in enhancing, or at the very least, not impede the human joy. This discussion deserves ongoing exploration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).
Methods
In this prospective case–control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (n: 30) and the control group (n: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.
Results
The AoI diameter was 4.8 ± 0.95 mm in the ICP group and 4.2 ± 0.62 mm in the control group, indicating a statistically significant difference (p = 0.003). The AoI Doppler flow parameters did not significantly differ between the groups (p > 0.05). When evaluated in subgroups according to disease severity, the AoI diameter and Doppler measurements did not significantly differ between the mild and severe ICP cases (p > 0.05). The AoI diameter was significantly larger in those requiring admission to the neonatal intensive care unit (NICU) (p = 0.005). This diameter was also larger in patients with fetal distress, albeit with no statistically significant difference (p = 0.65).
Conclusions
ICP is a pathology with known adverse fetal cardiac effects, but there is no effective method to predict adverse perinatal outcomes. The enlarged AoI diameter in the fetuses of mothers with ICP and the association of this enlargement with NICU requirements are important findings of this study. Further research with a larger number of patients is necessary to evaluate the clinical utility of fetal AoI diameter and Doppler parameters in ICP.
{"title":"Evaluation of fetal aortic isthmus diameter and flow in pregnant women with intrahepatic cholestasis of pregnancy; may it be a marker of poor perinatal outcomes?","authors":"Ezgi Başaran, Fatma Doğa Öcal, Atakan Tanaçan, Zahid Ağaoğlu, Göksun Ipek, Betül Akgün Aktaş, Dilek Şahin","doi":"10.1111/jog.16222","DOIUrl":"10.1111/jog.16222","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the fetal aortic isthmus (AoI) diameter and flow in pregnant women diagnosed with intrahepatic cholestasis of pregnancy (ICP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective case–control study, fetal AoI diameter and Doppler measurements were performed in the ICP group (<i>n</i>: 30) and the control group (<i>n</i>: 42). Clinical characteristics, fetal AoI diameter and Doppler measurements, serum bile acid levels, liver enzyme levels, and obstetric and perinatal outcomes were compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The AoI diameter was 4.8 ± 0.95 mm in the ICP group and 4.2 ± 0.62 mm in the control group, indicating a statistically significant difference (<i>p</i> = 0.003). The AoI Doppler flow parameters did not significantly differ between the groups (<i>p</i> > 0.05). When evaluated in subgroups according to disease severity, the AoI diameter and Doppler measurements did not significantly differ between the mild and severe ICP cases (<i>p</i> > 0.05). The AoI diameter was significantly larger in those requiring admission to the neonatal intensive care unit (NICU) (<i>p</i> = 0.005). This diameter was also larger in patients with fetal distress, albeit with no statistically significant difference (<i>p</i> = 0.65).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ICP is a pathology with known adverse fetal cardiac effects, but there is no effective method to predict adverse perinatal outcomes. The enlarged AoI diameter in the fetuses of mothers with ICP and the association of this enlargement with NICU requirements are important findings of this study. Further research with a larger number of patients is necessary to evaluate the clinical utility of fetal AoI diameter and Doppler parameters in ICP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Twin pregnancies affect maternal circulation by increasing the circulating blood volume and enlarging the uterus due to excess amniotic fluid. Nevertheless, how twin-to-twin transfusion syndrome (TTTS) affects maternal circulation remains unclear. Our aim was to examine maternal circulation changes at TTTS onset.
Methods
This cohort study was conducted at the Toho University Omori Medical Center from October 2022 to September 2023. Patients were divided into three groups, singleton pregnancy (singleton), uncomplicated monochorionic diamniotic (MD) twin pregnancy (nMD), and TTTS groups. We prospectively collected echocardiographic data to evaluate the left ventricular function, left ventricular contractility, diastolic performance, and inferior vena cava diameter.
Results
Thirty-one, 17, and 18 patients were assigned to the singleton, nMD, and TTTS groups, respectively. The left ventricular end-systolic volume (ESV) was significantly lower in the TTTS group than in the nMD group [ESV: 23.9 ± 9.2 mL vs. 13.3 ± 8.4 mL]. The left ventricular end-diastolic volume (EDV) was no significant difference, but a decreasing trend in the TTTS group than in the nMD group. The left ventricular ejection fraction was significantly lower in the nMD group than in the TTTS group [72.2 ± 6.4% vs. 80.1 ± 5.9%]. The heart rate was significantly higher in the TTTS group than in the other two groups. Cardiac output was similar among the groups.
Conclusions
MD twin pregnancy with TTTS may decrease circulating blood volumes. Maternal cardiac function may be adapted to compensate for cardiac output in patients with TTTS.
{"title":"Maternal cardiovascular dynamics in twin pregnancies complicated by twin-to-twin transfusion syndrome","authors":"Hikari Kotaki, Mayu Tachihara, Mio Kamiya, Makiko Shimabukuro, Junya Sakuma, Mayumi Takano, Sumito Nagasaki, Hiroshi Ohara, Masahiko Nakata","doi":"10.1111/jog.16224","DOIUrl":"10.1111/jog.16224","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Twin pregnancies affect maternal circulation by increasing the circulating blood volume and enlarging the uterus due to excess amniotic fluid. Nevertheless, how twin-to-twin transfusion syndrome (TTTS) affects maternal circulation remains unclear. Our aim was to examine maternal circulation changes at TTTS onset.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort study was conducted at the Toho University Omori Medical Center from October 2022 to September 2023. Patients were divided into three groups, singleton pregnancy (singleton), uncomplicated monochorionic diamniotic (MD) twin pregnancy (nMD), and TTTS groups. We prospectively collected echocardiographic data to evaluate the left ventricular function, left ventricular contractility, diastolic performance, and inferior vena cava diameter.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-one, 17, and 18 patients were assigned to the singleton, nMD, and TTTS groups, respectively. The left ventricular end-systolic volume (ESV) was significantly lower in the TTTS group than in the nMD group [ESV: 23.9 ± 9.2 mL vs. 13.3 ± 8.4 mL]. The left ventricular end-diastolic volume (EDV) was no significant difference, but a decreasing trend in the TTTS group than in the nMD group. The left ventricular ejection fraction was significantly lower in the nMD group than in the TTTS group [72.2 ± 6.4% vs. 80.1 ± 5.9%]. The heart rate was significantly higher in the TTTS group than in the other two groups. Cardiac output was similar among the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>MD twin pregnancy with TTTS may decrease circulating blood volumes. Maternal cardiac function may be adapted to compensate for cardiac output in patients with TTTS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The purpose of this study is to clarify the frequencies of fresh frozen plasma (FFP) ± fibrinogen concentrate administration (fibrinogen concentrate [FC] therapy) and antithrombin (AT) concentrate administration (AT therapy) for the women with obstetrical disseminated intravascular coagulation (DIC).
Methods
Two retrospective multicenter case–control studies as Study-1 (January–December 2018) and Study-2 (July 2022–June 2023) were conducted. Study-1 was the historical control of Study-2. All participants experienced a blood loss of ≥1000 mL during vaginal delivery or ≥2000 mL during cesarean section. All participants were subsequently assigned to the DIC group or non-DIC group.
Results
Study-1 comprised 175 women (obstetrical DIC, 27; control, 148; by the previous criteria) and Study-2 comprised 175 women (obstetrical DIC, 9; control, 166; by the new criteria). The frequencies of FFP (±FC therapy) or FC therapy in DIC group were significantly higher than non-DIC group in Study-1 (88.9% vs. 25.0%, 44.4% vs. 4.0%) and Study-2 (100% vs. 24.7%, 77.8% vs. 5.4%); however, the frequencies of AT therapy were similar. Furthermore, in the DIC group, all women with fibrinogen <150 mg/dL received FFP ± FC therapy in Study-1 (n = 19) and Study-2 (n = 8); however, those with AT activity <70% received AT therapy (16.7% [4/24] and 12.5% [1/8], respectively).
Conclusion
We revealed an association between the high frequency of FFP ± FC therapy and lower fibrinogen levels, but a low frequency of AT therapy regardless of AT activity, in obstetrical DIC regardless of diagnosis criteria.
{"title":"Fresh frozen plasma, fibrinogen concentrate, and antithrombin concentrate administration for obstetrical disseminated intravascular coagulation by the Japanese previous and new criteria","authors":"Mamoru Morikawa, Shigetaka Matsunaga, Shintaro Makino, Yoshiharu Takeda, Hironobu Hyodo, Masafumi Nii, Mariko Serizawa, Eriko Eto, Jun Takeda, Tomoko Adachi, Takao Kobayashi, Atsuo Itakura","doi":"10.1111/jog.16220","DOIUrl":"10.1111/jog.16220","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The purpose of this study is to clarify the frequencies of fresh frozen plasma (FFP) ± fibrinogen concentrate administration (fibrinogen concentrate [FC] therapy) and antithrombin (AT) concentrate administration (AT therapy) for the women with obstetrical disseminated intravascular coagulation (DIC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two retrospective multicenter case–control studies as Study-1 (January–December 2018) and Study-2 (July 2022–June 2023) were conducted. Study-1 was the historical control of Study-2. All participants experienced a blood loss of ≥1000 mL during vaginal delivery or ≥2000 mL during cesarean section. All participants were subsequently assigned to the DIC group or non-DIC group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Study-1 comprised 175 women (obstetrical DIC, 27; control, 148; by the previous criteria) and Study-2 comprised 175 women (obstetrical DIC, 9; control, 166; by the new criteria). The frequencies of FFP (±FC therapy) or FC therapy in DIC group were significantly higher than non-DIC group in Study-1 (88.9% vs. 25.0%, 44.4% vs. 4.0%) and Study-2 (100% vs. 24.7%, 77.8% vs. 5.4%); however, the frequencies of AT therapy were similar. Furthermore, in the DIC group, all women with fibrinogen <150 mg/dL received FFP ± FC therapy in Study-1 (<i>n</i> = 19) and Study-2 (<i>n</i> = 8); however, those with AT activity <70% received AT therapy (16.7% [4/24] and 12.5% [1/8], respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We revealed an association between the high frequency of FFP ± FC therapy and lower fibrinogen levels, but a low frequency of AT therapy regardless of AT activity, in obstetrical DIC regardless of diagnosis criteria.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pregnancy-related anatomic, physiologic, and hormonal factors can occur at different stages of pregnancy and affect sleep disturbances. The relationship between sleep problems during pregnancy and postpartum depressive symptoms as well as neonatal condition at delivery have not been well described. This study hypothesized that sleep problems are associated with postpartum depressive symptoms and adverse neonatal outcomes at delivery.
Methods
This study conducted a prospective study for perinatal women (n = 683, 30.54 ± 5.11 years old) to evaluate sleep problems during pregnancy using the Pittsburgh sleep quality index (PSQI) and Berlin questionnaire, postpartum depressive symptoms using Edinburgh postnatal depression scale (EPDS), and clinical signs of neonatal condition at delivery using the Apgar score.
Results
PSQI total score during pregnancy were significantly higher in those with postpartum depressive symptoms than those without 1 month after delivery. PSQI score in the third trimester was significantly associated with postpartum depressive symptoms even after adjustment for relevant confounding factors and self-reported lifetime depression (odds ratio = 1.19, 95% confidence interval = 1.03–1.36, p = 0.015). The Apgar score at 5 min after birth was significantly lower in those with obstructive sleep apnea (OSA) than those without OSA in the second and third trimesters, although mean scores were within the normal range.
Conclusion
This study revealed that sleep problems during pregnancy influence postpartum depression 1 month after delivery. OSA during pregnancy may lead to risks of delivery. Attention should be paid to sleep health during pregnancy to ensure the mental health of mothers and a safe delivery.
{"title":"Association between sleep problems during pregnancy and postpartum depressive symptoms as well as condition of newborn at delivery","authors":"Yoko Komada, Sho-Ichi Kawakami, Satoko Furuie, Rena Mori, Azusa Ikegami","doi":"10.1111/jog.16219","DOIUrl":"10.1111/jog.16219","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pregnancy-related anatomic, physiologic, and hormonal factors can occur at different stages of pregnancy and affect sleep disturbances. The relationship between sleep problems during pregnancy and postpartum depressive symptoms as well as neonatal condition at delivery have not been well described. This study hypothesized that sleep problems are associated with postpartum depressive symptoms and adverse neonatal outcomes at delivery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study conducted a prospective study for perinatal women (<i>n</i> = 683, 30.54 ± 5.11 years old) to evaluate sleep problems during pregnancy using the Pittsburgh sleep quality index (PSQI) and Berlin questionnaire, postpartum depressive symptoms using Edinburgh postnatal depression scale (EPDS), and clinical signs of neonatal condition at delivery using the Apgar score.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>PSQI total score during pregnancy were significantly higher in those with postpartum depressive symptoms than those without 1 month after delivery. PSQI score in the third trimester was significantly associated with postpartum depressive symptoms even after adjustment for relevant confounding factors and self-reported lifetime depression (odds ratio = 1.19, 95% confidence interval = 1.03–1.36, <i>p</i> = 0.015). The Apgar score at 5 min after birth was significantly lower in those with obstructive sleep apnea (OSA) than those without OSA in the second and third trimesters, although mean scores were within the normal range.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study revealed that sleep problems during pregnancy influence postpartum depression 1 month after delivery. OSA during pregnancy may lead to risks of delivery. Attention should be paid to sleep health during pregnancy to ensure the mental health of mothers and a safe delivery.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143046328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiayin Yu, Yiyang Wang, Liqun Liu, Yaolong Xiao, Gang Yu
Aim
To examine the prognostic impact of textbook oncologic outcome (TOO) in patients with advanced ovarian cancer undergoing primary chemotherapy, along with identifying the risk factors for TOO failure.
Methods
Patients who underwent neoadjuvant chemotherapy followed by interval debulking surgery for advanced ovarian cancer at a tertiary center between 2014 and 2019 were retrospectively reviewed. TOO was defined as complete cytoreduction, no severe complications, no prolonged hospital stay, no readmission, no delayed initiation of adjuvant chemotherapy, and no 90-day mortality. The associations between TOO and clinical characteristics (survival) were examined using logistic and Cox regression analyses.
Results
Among 165 patients, 65 (39.4%) achieved TOO. The most common reason for TOO failure was incomplete cytoreduction (n = 46, 27.9%). Older age (p = 0.049) and visceral obesity (p = 0.030) were independently associated with TOO failure. Patients who achieved TOO had significantly prolonged overall survival (OS; median: 52 vs. 31 months, p = 0.010) and progression-free survival (PFS; median: not reached vs. 19 months, p = 0.006) compared to those who did not achieve TOO. Multivariate analysis revealed that TOO achievement was an independent protective factor for OS (hazard ratio [HR] 0.591, 95% confidence interval [CI] 0.387–0.905, p = 0.015) and PFS (HR 0.626, 95% CI 0.410–0.956, p = 0.030).
Conclusions
TOO is an effective predictor of favorable outcomes in patients with advanced ovarian cancer undergoing interval debulking surgery. Factors such as older age and visceral obesity may hinder the achievement of TOO.
{"title":"Assessment of textbook oncologic outcome after neoadjuvant chemotherapy and interval debulking surgery for advanced ovarian cancer","authors":"Jiayin Yu, Yiyang Wang, Liqun Liu, Yaolong Xiao, Gang Yu","doi":"10.1111/jog.16218","DOIUrl":"10.1111/jog.16218","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To examine the prognostic impact of textbook oncologic outcome (TOO) in patients with advanced ovarian cancer undergoing primary chemotherapy, along with identifying the risk factors for TOO failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients who underwent neoadjuvant chemotherapy followed by interval debulking surgery for advanced ovarian cancer at a tertiary center between 2014 and 2019 were retrospectively reviewed. TOO was defined as complete cytoreduction, no severe complications, no prolonged hospital stay, no readmission, no delayed initiation of adjuvant chemotherapy, and no 90-day mortality. The associations between TOO and clinical characteristics (survival) were examined using logistic and Cox regression analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 165 patients, 65 (39.4%) achieved TOO. The most common reason for TOO failure was incomplete cytoreduction (<i>n</i> = 46, 27.9%). Older age (<i>p</i> = 0.049) and visceral obesity (<i>p</i> = 0.030) were independently associated with TOO failure. Patients who achieved TOO had significantly prolonged overall survival (OS; median: 52 vs. 31 months, <i>p</i> = 0.010) and progression-free survival (PFS; median: not reached vs. 19 months, <i>p</i> = 0.006) compared to those who did not achieve TOO. Multivariate analysis revealed that TOO achievement was an independent protective factor for OS (hazard ratio [HR] 0.591, 95% confidence interval [CI] 0.387–0.905, <i>p</i> = 0.015) and PFS (HR 0.626, 95% CI 0.410–0.956, <i>p</i> = 0.030).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TOO is an effective predictor of favorable outcomes in patients with advanced ovarian cancer undergoing interval debulking surgery. Factors such as older age and visceral obesity may hinder the achievement of TOO.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The Women's Health Care Committee was established in 2010 to improve the health of women. In the current academic year, this committee established seven subcommittees aimed at understanding diseases related to various age groups of women, including adolescence, sexual maturity, and menopause, and promoting research to improve the quality of life. Additionally, socially significant research has focused on infections, particularly resistant bacteria. The activities of each subcommittee are described. This report is based on the Japanese version of the annual report (Acta Obst Gynaec Jpn 2024;76(6):682–87).
{"title":"Women's health care committee, Japan Society of Obstetrics and Gynecology: Annual report—2024","authors":"Tsuyoshi Higuchi, Takeshi Iwasa","doi":"10.1111/jog.16192","DOIUrl":"10.1111/jog.16192","url":null,"abstract":"<p>The Women's Health Care Committee was established in 2010 to improve the health of women. In the current academic year, this committee established seven subcommittees aimed at understanding diseases related to various age groups of women, including adolescence, sexual maturity, and menopause, and promoting research to improve the quality of life. Additionally, socially significant research has focused on infections, particularly resistant bacteria. The activities of each subcommittee are described. This report is based on the Japanese version of the annual report (<i>Acta Obst Gynaec Jpn</i> 2024;76(6):682–87).</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Keiko Yamamoto, Koji Uchiyama, Yoshiko Abe, Nobuko Takaoka, Yasuo Haruyama, Gen Kobashi
Aim
The long-term effects of the COVID-19 pandemic on birth and pregnancy trends in Japan remain unclear. Although major sporting events are usually followed by an increase in births 9 months later, Japan's fifth wave of COVID-19 occurred during the Olympics held in Japan during the summer of 2021. In this study, we analyzed how the number of births and pregnancies changed during the COVID-19 pandemic and large-scale events in Japan.
Methods
We utilized monthly vital statistical data from birth certificates spanning the years 2010 to 2022. Our analysis followed the identification, estimation, and forecasting stages of autoregressive integrated moving average (ARIMA) modeling. We found the ARIMA (1, 12, 12) model to be adequate for forecasting the monthly number of births.
Results
Comparing actual birth data from 2020 to 2022 with our forecast, we observed a significant decrease in births across all of Japan, urban residential areas, and 13 prefectures—primarily metropolitan regions—in January 2021 and May 2022. We also observed a decrease in pregnancy notifications in May 2020, May 2021, and October 2021. The decrease in births in May 2022 in Japan aligns with the decrease in pregnancy notifications 8 months earlier in October 2021.
Conclusions
Although major sporting events are expected to lead to an increase in the number of births approximately 9 months later, the number of births decreased in May 2022 during the fifth wave of the COVID-19 pandemic in Japan. These findings suggest that the number of pregnancies and births should be monitored in future pandemics with particular attention to fertility trends.
{"title":"Birth and pregnancy numbers decreased during the COVID-19 pandemic in Japan: A time series analysis with the ARIMA model","authors":"Keiko Yamamoto, Koji Uchiyama, Yoshiko Abe, Nobuko Takaoka, Yasuo Haruyama, Gen Kobashi","doi":"10.1111/jog.16202","DOIUrl":"10.1111/jog.16202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The long-term effects of the COVID-19 pandemic on birth and pregnancy trends in Japan remain unclear. Although major sporting events are usually followed by an increase in births 9 months later, Japan's fifth wave of COVID-19 occurred during the Olympics held in Japan during the summer of 2021. In this study, we analyzed how the number of births and pregnancies changed during the COVID-19 pandemic and large-scale events in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We utilized monthly vital statistical data from birth certificates spanning the years 2010 to 2022. Our analysis followed the identification, estimation, and forecasting stages of autoregressive integrated moving average (ARIMA) modeling. We found the ARIMA (1, 12, 12) model to be adequate for forecasting the monthly number of births.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Comparing actual birth data from 2020 to 2022 with our forecast, we observed a significant decrease in births across all of Japan, urban residential areas, and 13 prefectures—primarily metropolitan regions—in January 2021 and May 2022. We also observed a decrease in pregnancy notifications in May 2020, May 2021, and October 2021. The decrease in births in May 2022 in Japan aligns with the decrease in pregnancy notifications 8 months earlier in October 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although major sporting events are expected to lead to an increase in the number of births approximately 9 months later, the number of births decreased in May 2022 during the fifth wave of the COVID-19 pandemic in Japan. These findings suggest that the number of pregnancies and births should be monitored in future pandemics with particular attention to fertility trends.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ángel Santalla-Hernández, Mariña Naveiro-Fuentes, María Setefilla López-Criado, Roi Naveiro-Flores, Jorge Fernández-Parra
Aim
The aim of this study was to evaluate the efficacy after 2 years follow-up of transvaginal radiofrequency ablation (TVRA) to treat myomas, and to identify factors predictive of the response to the treatment.
Methods
This is a prospective cohort study of a 2-year follow-up of 65 patients who underwent TVRA for the treatment uterine fibroids at Virgen de las Nieves University Hospital in Granada, Spain. Ultrasound mean fibroid volume, symptom severity scale, total bleeding days, complications, pregnancy outcomes were recorded.
Results
Statistically significant improvements in symptoms and bleeding were observed at 6, 12, and 24 months after the procedure. The mean myoma volume (cc) was significantly lower (p < 0.05) at 12 and 24 months, with a mean reduction in myoma volume of more than 80% and 60%, respectively. After a 24-month follow-up, 5 patients (7.7%) required additional surgical treatment to control symptoms. Patient age (>40 years), initial myoma size, and the timing of radiofrequency were identified as factors related to outcomes in the bivariate analysis.
Conclusions
Transvaginal radiofrequency ablation is an effective and safe technique for the treatment of myomas after 2 years of follow-up, which improves the symptoms of the patients and decreases the final volume of the myoma.
{"title":"Clinical outcomes after 2-year follow-up of transvaginal radiofrequency ablation of symptomatic uterine fibroids","authors":"Ángel Santalla-Hernández, Mariña Naveiro-Fuentes, María Setefilla López-Criado, Roi Naveiro-Flores, Jorge Fernández-Parra","doi":"10.1111/jog.16216","DOIUrl":"10.1111/jog.16216","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the efficacy after 2 years follow-up of transvaginal radiofrequency ablation (TVRA) to treat myomas, and to identify factors predictive of the response to the treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a prospective cohort study of a 2-year follow-up of 65 patients who underwent TVRA for the treatment uterine fibroids at Virgen de las Nieves University Hospital in Granada, Spain. Ultrasound mean fibroid volume, symptom severity scale, total bleeding days, complications, pregnancy outcomes were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistically significant improvements in symptoms and bleeding were observed at 6, 12, and 24 months after the procedure. The mean myoma volume (cc) was significantly lower (<i>p</i> < 0.05) at 12 and 24 months, with a mean reduction in myoma volume of more than 80% and 60%, respectively. After a 24-month follow-up, 5 patients (7.7%) required additional surgical treatment to control symptoms. Patient age (>40 years), initial myoma size, and the timing of radiofrequency were identified as factors related to outcomes in the bivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Transvaginal radiofrequency ablation is an effective and safe technique for the treatment of myomas after 2 years of follow-up, which improves the symptoms of the patients and decreases the final volume of the myoma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medroxyprogesterone acetate (MPA) is a promising fertility-sparing treatment for early stage endometrial cancer; however, it has a high recurrence rate and is inferior to surgery. Although the site of recurrence is mostly the endometrium, we here report a case of metastatic recurrence to the para-aortic lymph node with endometrial recurrence despite a careful follow-up. A 31-year-old woman was diagnosed with grade 1 endometrioid carcinoma, stage IA without myometrial invasion. She requested fertility-sparing treatment and underwent a 48-week MPA therapy with complete remission. Follow-up continued with ultrasonography and endometrial biopsy every 3 and 6 months, respectively; however, at 10 months following MPA therapy, cancer recurrence was detected in the endometrium and para-aortic lymph node, requiring hysterectomy, bilateral adnexectomy, and lymph node dissection, followed by paclitaxel/carboplatin chemotherapy. This case report highlights that lymph node recurrence can develop despite careful follow-up following complete remission with MPA therapy for stage IA endometrial cancer.
{"title":"Endometrial cancer with para-aortic lymph node metastasis following medroxyprogesterone acetate therapy: A case report","authors":"Miku Nakamura, Yoshifumi Takahashi, Takahiro Koyanagi, Yuji Takei, Hiroyuki Fujiwara","doi":"10.1111/jog.16217","DOIUrl":"10.1111/jog.16217","url":null,"abstract":"<p>Medroxyprogesterone acetate (MPA) is a promising fertility-sparing treatment for early stage endometrial cancer; however, it has a high recurrence rate and is inferior to surgery. Although the site of recurrence is mostly the endometrium, we here report a case of metastatic recurrence to the para-aortic lymph node with endometrial recurrence despite a careful follow-up. A 31-year-old woman was diagnosed with grade 1 endometrioid carcinoma, stage IA without myometrial invasion. She requested fertility-sparing treatment and underwent a 48-week MPA therapy with complete remission. Follow-up continued with ultrasonography and endometrial biopsy every 3 and 6 months, respectively; however, at 10 months following MPA therapy, cancer recurrence was detected in the endometrium and para-aortic lymph node, requiring hysterectomy, bilateral adnexectomy, and lymph node dissection, followed by paclitaxel/carboplatin chemotherapy. This case report highlights that lymph node recurrence can develop despite careful follow-up following complete remission with MPA therapy for stage IA endometrial cancer.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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