Journal of Obstetrics and Gynaecology Research最新文献

Medroxyprogesterone acetate (MPA) is a promising fertility-sparing treatment for early stage endometrial cancer; however, it has a high recurrence rate and is inferior to surgery. Although the site of recurrence is mostly the endometrium, we here report a case of metastatic recurrence to the para-aortic lymph node with endometrial recurrence despite a careful follow-up. A 31-year-old woman was diagnosed with grade 1 endometrioid carcinoma, stage IA without myometrial invasion. She requested fertility-sparing treatment and underwent a 48-week MPA therapy with complete remission. Follow-up continued with ultrasonography and endometrial biopsy every 3 and 6 months, respectively; however, at 10 months following MPA therapy, cancer recurrence was detected in the endometrium and para-aortic lymph node, requiring hysterectomy, bilateral adnexectomy, and lymph node dissection, followed by paclitaxel/carboplatin chemotherapy. This case report highlights that lymph node recurrence can develop despite careful follow-up following complete remission with MPA therapy for stage IA endometrial cancer.

Cervical dilatation, uterine evacuation, and curettage (D&E&C) are common gynecological procedures for abortion, yet they carry risks of complications such as uterine perforation and intra-abdominal organ incarceration. Here, we report a rare case of a breastfeeding patient who had an embedded abdominal greater omentum in the anterior wall of the uterus and into the uterine cavity during D&E&C. We used combined hysteroscopic and laparoscopic treatment for this case and successfully removed the embedded greater omentum. Our experience underscores the importance of vigilant intraoperative monitoring and prompt management to prevent serious complications like infection and bowel injury. In conclusion, hysteroscopic and laparoscopic combination treatment can be a preferred approach to avoid serious adverse outcomes for uterus perforation patients who developed omentum majus incarceration.

EXPRESSION OF CONCERN: H. A. Hashim, N. El Lakany, L. Sherief, “ Combined Metformin and Clomiphene Citrate Versus Laparoscopic Ovarian Diathermy for Ovulation Induction in Clomiphene-Resistant Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial,” The Journal of Obstetrics and Gynaecology Research 37, no. 3 (2011): 169–177, https://doi.org/10.1111/j.1447-0756.2010.01383.x.

This Expression of Concern is for the above article, published online on 28 November 2010, in Wiley Online Library (http://onlinelibrary.wiley.com/), and has been issued by agreement between the journal Editor-in-Chief, Hiroaki Kajiyama; and John Wiley & Sons, Australia, Ltd. The Expression of Concern has been agreed upon following concerns raised by a third party and further investigation by Wiley's Integrity Assurance and Case Resolution team which revealed concerns about the validity of the statistical analysis and the data presented in the article. An institutional investigation at Mansoura University into the reliability of the published clinical trial was requested in 2021. In response to inquiries by the publisher, the authors have stated that the original data are no longer available and that their data presented in this article are valid. The author previously provided a letter from Mansoura University, dated March 17, 2012, which confirms the author did work and publish studies between 2009 and 2012 at the institute. In 2014, an internal investigation conducted by professors affiliated with Mansoura University reported serious inconsistencies in the research reported in this article. However, the publisher was unsuccessful in receiving a direct response from Mansoura University with regard to the current investigation, despite our attempts. The journal has decided to issue an Expression of Concern to alert the readers as the authenticity of the data could not be confirmed. The authors disagree with the Expression of Concern.