Journal of Obstetrics and Gynaecology Research最新文献

{"title":"Where the Line Is Drawn: The Prognostic Role of Surgical Margins in Vulvar SCC","authors":"Duygu Güzel,&nbsp;Coşan Terek,&nbsp;Ayşegül Besler,&nbsp;Gürdeniz Serin,&nbsp;Züleyha Önal,&nbsp;Levent Akman,&nbsp;Osman Zekioğlu,&nbsp;Necmettin Özdemir,&nbsp;Aydın Özsaran,&nbsp;Nuri Yıldırım","doi":"10.1111/jog.70183","DOIUrl":"10.1111/jog.70183","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the clinical, pathological, and treatment-related factors influencing recurrence and mortality in patients diagnosed with vulvar squamous cell carcinoma (SCC), with a specific focus on the prognostic significance of surgical margin width.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 70 patients with histologically confirmed vulvar SCC treated between 2000 and 2020 at a tertiary academic center. Patients were categorized based on tumor-free surgical margin width (&lt; 2 mm, 2–8 mm, &gt; 8 mm). Demographic, clinical, and histopathological parameters were analyzed using Cox regression and Kaplan–Meier methods to assess their impact on disease-free survival (DFS) and overall survival (OS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median age at diagnosis was 68 years, and 74.3% of cases were FIGO stage I. Median DFS and OS were 46 and 56 months, respectively. Age and tumor grade emerged as independent predictors of mortality and recurrence. Surgical margins &lt; 2 mm were significantly associated with increased recurrence risk (<i>p</i> = 0.001), while no significant effect on OS was observed. Margins ≥ 2 mm conferred a lower recurrence risk, especially in the 2–8 mm group. Lymphovascular space invasion (LVSI) and depth of invasion were significant in univariate analysis but lost significance after adjustment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surgical margin width, particularly margins &lt; 2 mm, is a strong predictor of local recurrence in vulvar SCC. Age and tumor grade are independent predictors of prognosis. These findings highlight the importance of individualized surgical planning and support the development of risk-adapted treatment strategies. Future prospective studies are warranted to refine optimal margin thresholds and improve outcomes, especially in high-risk populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Prolonged Surgical Waiting Time on 5-Year Progression-Free Survival in Patients With Endometrial Cancer","authors":"Ascharavadee Pulsawat,&nbsp;Sitchuphong Noothong,&nbsp;Nathapol Sirimusika","doi":"10.1111/jog.70175","DOIUrl":"10.1111/jog.70175","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the impact of surgical waiting time (SWT) on 5-year progression-free survival (PFS). Secondary objectives were to evaluate 5-year overall survival (OS) and prognostic factors for recurrence and OS in endometrial cancer (EC), considering Thailand's Key Performance Indicator (KPI) recommending surgery within 4 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort study included 377 patients with histologically confirmed EC who underwent primary surgery at Hatyai Hospital between October 2016 and September 2024. SWT was defined as the time from diagnostic biopsy to definitive surgery and categorized as early (≤ 4 weeks) or delayed (&gt; 4 weeks). Survival outcomes were assessed using Kaplan–Meier curves and log-rank tests. Prognostic factors were analyzed using Cox proportional hazards models.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median SWT was 32 days. Median follow-up was 23 months. Delayed surgery correlated with higher BMI, larger tumors, and increased recurrence (12.7% vs. 4.9%, <i>p</i> = 0.010). Advanced FIGO stage, non-endometrioid histology, grade 3 tumors, LVSI, and delayed SWT were significant recurrence risk factors. Multivariate analysis confirmed advanced stage (HR: 5.15, <i>p</i> &lt; 0.001) and SWT &gt; 4 weeks (HR: 3.22, <i>p</i> = 0.011) as independent predictors. Recurrence risk increased with longer delays (&gt; 6 weeks: HR: 3.22; &gt; 8 weeks: HR: 3.16). Kaplan–Meier curves showed significantly reduced PFS with prolonged SWT, while its effect on 5-year OS was not significant (<i>p</i> = 0.1).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Surgical delays beyond 4 weeks were associated with reduced PFS and increased recurrence, supporting Thailand's KPI and underscores the importance of timely surgery. The short follow-up may limit interpretation of long-term outcomes. Longer follow-up is warranted to confirm these results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uterine Mapping for Lymph Node Metastasis in Endometrial Cancer: A Multicenter Retrospective Cohort Study","authors":"Baydemir Sahin Kaan,&nbsp;Oncu Hande Nur,&nbsp;Baspinar Zeynep,&nbsp;Koksal Oguz Kaan,&nbsp;Hanedan Candost,&nbsp;Korkmaz Vakkas","doi":"10.1111/jog.70180","DOIUrl":"10.1111/jog.70180","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the association between uterine tumor localization and lymph node metastasis (LNM) in endometrial cancer through pathological uterine mapping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This multicenter retrospective cohort study included 427 patients with endometrial carcinoma who underwent total hysterectomy, bilateral salpingo-oophorectomy, and systematic lymphadenectomy. Tumor localization was classified based on a six-site pathological mapping model: isolated lower uterine segment (LUS), LUS + corpus, corpus-only, corpus+fundus, fundus-only, and total uterine cavity. LNM patterns and pathological features were compared across sites. Logistic regression was used to determine independent predictors of LNM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The highest LNM rates were observed in tumors involving the LUS + corpus (37.0%) and total uterine cavity (32.4%), whereas the lowest rate was seen in corpus-only tumors (10.2%) (<i>p</i> &lt; 0.001). Tumors in high-risk sites featured significantly higher rates of deep myometrial invasion, substantial LVSI, and high-grade histology. In multivariate analysis, substantial LVSI (OR: 9.2, <i>p</i> &lt; 0.001), any LUS involvement (OR: 2.6, <i>p</i> = 0.001), aggressive histology (OR: 2.1, <i>p</i> = 0.017), and BMI (OR: 1.08, <i>p</i> = 0.025) independently predicted LNM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Pathological uterine mapping reveals that LUS involvement is an independent risk factor for lymphatic dissemination in endometrial cancer. Tumor site classification may enhance preoperative risk stratification and guide individualized surgical strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145912009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perinatal Management of Andersen–Tawil Syndrome Using a Wearable Cardioverter-Defibrillator: A Case Report","authors":"Yuta Sakaguchi,&nbsp;Sou Otsuki,&nbsp;Daisuke Izumi,&nbsp;Masaomi Chinushi,&nbsp;Takayuki Inomata","doi":"10.1111/jog.70181","DOIUrl":"10.1111/jog.70181","url":null,"abstract":"<div>\u0000 \u0000 <p>Andersen–Tawil syndrome (ATS), also known as congenital long QT syndrome type 7 (LQT7), is a rare inherited channelopathy caused by <i>KCNJ2</i> mutations and characterized by ventricular arrhythmias, periodic paralysis, and dysmorphic features. Pregnancy in women with ATS is extremely uncommon, and optimal perinatal management strategies are not well defined. We describe a 38-year-old primigravida with genetically confirmed ATS (p.R228X) who presented at 31 weeks of gestation without medication. During pregnancy, the burden of premature ventricular contractions and non-sustained ventricular tachycardia decreased compared with the pre-pregnancy period. At 36 weeks, atenolol and flecainide were introduced, and a wearable cardioverter-defibrillator (WCD) was applied, further reducing arrhythmias. A planned cesarean section at 37 weeks was uneventful, with favorable maternal and fetal outcomes. Postpartum, arrhythmias increased again, highlighting the importance of surveillance. This case demonstrates that combined pharmacological therapy and temporary WCD use may represent a safe and effective perinatal management strategy in high-risk pregnancies complicated by ATS.</p>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Psychometric Properties of the Human Papillomavirus-Know Questionnaire (HPV-Know-Q) to Assess the Knowledge of Women on HPV Infection and Related Outcomes.","authors":"Carmen González-Granados, Javier Rejas-Gutiérrez, Javier Calvo-Torres, Mar Ramírez-Mena, Javier F García-Santos, Mónica Bellón, María Fasero, Pluvio J Coronado","doi":"10.1111/jog.70154","DOIUrl":"https://doi.org/10.1111/jog.70154","url":null,"abstract":"<p><strong>Aim: </strong>To provide the psychometric properties of a novel patient-reported outcomes measurement (PROM), the HPV-Know-Q questionnaire, to assess the HPV-related knowledge in adult women in Spain.</p><p><strong>Methods: </strong>After reviewing literature and interviewing women with HPV infection, instrument items and domains were developed. A draft self-administered, multiple-choice questionnaire including relevant questions about HPV infection was pilot tested for comprehension and ease of completion. Psychometric evaluation of the final HPV-Know-Q questionnaire was performed in a cross-sectional, multicenter, validation study conducted in a representative sample of women with HPV infection attending gynecology consultations in Spain.</p><p><strong>Results: </strong>A total of 349 (153 HPV+/196 HPV-) women participated. HPV-Know-Q questionnaire had acceptable metric properties of feasibility, internal consistency and temporal stability (reliability). Construct validity was supported by analyzing item-to-item and item-to-domain correlation and know groups validity, which discriminated the knowledge on HPV of women related to their infection status, abnormal cytology, educational level and prior HPV vaccination. Concurrent validity was demonstrated with a significant correlation with other scales measuring mental and sexual functioning.</p><p><strong>Conclusion: </strong>The HPV-Know-Q questionnaire, a novel and innovative PROM, showed acceptable psychometric properties to evaluate the HPV knowledge in women that support its use in daily medical practice and research.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":"e70154"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146064424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Sentinel Lymph Node Sampling for Early Cervical Cancer: A Single Institute Study","authors":"Akari Hirakawa,&nbsp;Natsumi Iwai,&nbsp;Akihiro Yanai,&nbsp;Kana Matsukawa,&nbsp;Hinata Ohshiro,&nbsp;Kaho Hayashi,&nbsp;Mio Makita,&nbsp;Rika Iseki,&nbsp;Haruka Mieda,&nbsp;Miki Otsuki,&nbsp;Shihori Nakamura,&nbsp;Kota Yamauchi,&nbsp;Aya Takaori,&nbsp;Eri Kawai,&nbsp;Ayako Moribe,&nbsp;Machiko Kojima,&nbsp;Yuki Kozono,&nbsp;Akiko Okuda,&nbsp;Yumiko Yoshioka,&nbsp;Toshihiro Higuchi,&nbsp;Akihito Horie","doi":"10.1111/jog.70144","DOIUrl":"https://doi.org/10.1111/jog.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Radioisotope (RI) tracers were approved for use in gynecological cancers in Japan in 2023, and their application in sentinel lymph node (SLN) biopsy for cervical cancer is expected to expand. Our institution has been performing SLN biopsies for cervical cancer since 2009. This study aimed to evaluate the efficacy and safety of SLN biopsy in patients with early-stage cervical cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 136 patients with FIGO 2008 stage IA1 to IB1 cervical cancer who underwent hysterectomy with SLN mapping between January 2009 and December 2023. The SLNs were identified using a combination of RI and dye (patent blue) methods. Systematic pelvic lymph node dissection (PLND) was performed during the initial introduction period. Patients were divided into two groups: the PLND group (<i>n</i> = 50), who underwent systematic dissection until August 2012, and the sentinel node navigation surgery (SNNS) group (<i>n</i> = 86), who underwent SLN biopsy with systematic dissection only when SLN metastasis was detected. Recurrence, prognosis, and complications were compared between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the PLND group, the SLN detection rate was 84%, and the sensitivity for detecting lymph node metastasis was 100%. Lymphedema occurred in 5.8% and 20.0% of patients in the SNNS and PLND groups, respectively. The 5-year progression-free survival rates in the SNNS and PLND groups were 88.6% and 92.2% respectively. The 5-year overall survival rates were 95.5% and 97.8%, respectively, with no significant differences observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SLN biopsy can improve the quality of life without compromising oncologic outcomes in early-stage cervical cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145887270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Use of the Combination of CA72-4 and Tumor Volume in Mucinous Ovarian Tumors","authors":"Hajime Araki,&nbsp;Akira Yokoi,&nbsp;Keita Kuroda,&nbsp;Kazuhiro Suzuki,&nbsp;Kosuke Yoshida,&nbsp;Masato Yoshihara,&nbsp;Satoshi Tamauchi,&nbsp;Nobuhisa Yoshikawa,&nbsp;Kaoru Niimi,&nbsp;Hiroaki Kajiyama","doi":"10.1111/jog.70177","DOIUrl":"10.1111/jog.70177","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Mucinous ovarian cancer (MOC) is a rare epithelial ovarian cancer subtype with poor prognosis, particularly in advanced stages. Differentiating MOC from mucinous borderline ovarian tumor (MBT) remains clinically challenging, often leading to delayed or inadequate treatment. Accurate preoperative diagnosis is crucial for guiding surgical strategies and improving patient outcomes. This study evaluated preoperative clinical factors that can distinguish MOC from MBT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We retrospectively analyzed 46 ovarian mucinous tumors diagnosed between 2017 and 2021, including 15 MOC and 31 MBT cases confirmed by histopathology. Patient age, tumor laterality, tumor size, tumor markers (CA125, CA19-9, CA72-4, CEA), and tumor volume were assessed. Tumor size was measured as the maximum magnetic resonance imaging diameter, whereas volume was calculated using three-dimensional imaging. Statistical analyses included the Mann–Whitney <i>U</i> test and receiver operating characteristic curve analysis, with AUC as a measure of diagnostic accuracy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the tumor markers, CA72-4 exhibited the highest diagnostic accuracy (area under the curve [AUC]: 0.834), with significantly higher levels in MOC than in MBT (<i>p</i> &lt; 0.001). Tumor size alone was an unreliable discriminator (AUC: 0.42). The tumor volume tended to be larger in MBT than in MOC (median: 2 362 878 cm³ vs. 1 262 436 cm³; <i>p</i> = 0.77). However, the combination of CA72-4 and tumor volume improved the diagnostic performance (AUC: 0.875).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combination of CA72-4 levels and tumor volume enhances preoperative differentiation between MOC and MBT. This combined approach may optimize surgical planning and improve patient outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-Based Management of Amniotic Fluid Embolism: A Systematic Review and Meta-Analysis of Clinical Interventions","authors":"Tsukasa Yoshida,&nbsp;Fumino Taketazu,&nbsp;Jun Takeda,&nbsp;Marie Furuta,&nbsp;Chisato Kodera,&nbsp;Masahiro Nakao,&nbsp;Hiroaki Tanaka,&nbsp;Shigetaka Matsunaga,&nbsp;Atsushi Sakurai,&nbsp;the Japan Resuscitation Council (JRC) Guideline Editorial Committee","doi":"10.1111/jog.70153","DOIUrl":"10.1111/jog.70153","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the effectiveness of therapeutic interventions for amniotic fluid embolism (AFE) through a systematic review and meta-analysis, focusing on survival outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PubMed, Embase, and the Cochrane Library were searched until June 2025 for eligible studies that evaluated therapeutic interventions for AFE. The quality of the evidence was assessed using the GRADE approach. A subgroup analysis was conducted to review all potentially effective interventions reported in case reports and case series.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two case–control studies comprising 272 patients with AFE met the inclusion criteria of this review. Platelet transfusion (adjusted Odds Ratio [OR] 0.23, 95% Confidence Interval [CI] 0.10–0.52) and fibrinogen administration (adjusted OR 0.44, 95% CI 0.21–0.92) were significantly more common among survivors, whereas hysterectomy, uterine artery embolization, red blood cell transfusion, fresh frozen plasma administration, Factor VIIa, and tranexamic acid showed no significant association with survival. The subgroup analysis identified interventions targeting circulatory support, inflammation control, coagulation management, and bleeding control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This systematic review suggests that platelet transfusion and fibrinogen administration may improve the survival of patients with AFE. Further research is required to develop individualized treatment strategies for this rare but potentially fatal obstetric emergency.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Oral Contraceptives and Endometrial Cancer Among Southeast Asian Women: A Secondary Analysis of Multicenter Case–Control Study","authors":"Kuntima Kantawee,&nbsp;Siwanon Rattanakanokchai,&nbsp;Chumnan Kietpeerakool","doi":"10.1111/jog.70176","DOIUrl":"10.1111/jog.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the association of combined oral contraceptives (COCs) use and endometrial cancer risk in Southeast Asian women.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a secondary analysis of a previously conducted multicenter case–control study with the recruitment between 2015 and 2021. Cases were women with histologically confirmed diagnoses of endometrial cancer. Controls were women admitted to different wards for other medical conditions and were individually matched to cases by age and admission date, at a ratio of three controls per case. Data regarding contraception practices were collected through interviews conducted by trained personnel using a standardized questionnaire. Conditional logistic regression models were used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 115 (30.4%) out of 378 cases and 574 (50.6%) out of 1134 controls reported a history of COCs use. The odds of endometrial cancer were lower in women who had ever used COCs than those who reported never use (aOR 0.60; 95% CI 0.44–0.82). For every additional 12 months of COCs use, the odds of endometrial cancer decreased by 10% (aOR 0.90; 95% CI 0.86–0.93). Former COCs users had a reduced odds of endometrial cancer for up to 30 years after discontinuation (aOR 0.44; 95% CI 0.25–0.77).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A noticeable trend was observed indicating a decline in the odds of endometrial cancer with increasing duration of COCs use. COCs users continued to receive long-term protection against endometrial cancer after discontinuation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"52 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145856897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes Towards Early Diagnosis of Cervical Cancer Among Women Applying to a Health Institution in Turkey","authors":"Serpil Özbaş,&nbsp;Seray Gerey,&nbsp;Şükran Özkahraman Koç","doi":"10.1111/jog.70174","DOIUrl":"10.1111/jog.70174","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cervical cancer is one of the most common preventable gynecologic cancers, yet it remains a major public health problem worldwide.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study was conducted to assess women's attitudes towards early detection of cervical cancer and to determine the factors affecting these attitudes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A descriptive cross-sectional study was conducted with 290 women admitted to a university hospital in Turkey between March and May 2025. Data were collected using a Personal Information Form and the Cervical Cancer Early Detection Attitude Scale Attitude Scale for Early Diagnosis of Cervical Cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age of the participants was 40.86 ± 10.80 years. 84.1% of the women had heard of the Pap smear test, and 61.7% had this test. The mean total attitude score was 102.53 ± 10.46, indicating generally positive attitudes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Women had positive attitudes towards early detection of cervical cancer. Improving access to counseling and screening services is necessary to reduce the burden of cervical cancer.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 12","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145804943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}