Journal of Obstetrics and Gynaecology Research最新文献_第10页

The Expression and Clinical Significance of C1orf106 in Low-Grade Serous Ovarian Cancer C1orf106在低级别浆液性卵巢癌中的表达及临床意义

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-23 DOI: 10.1111/jog.70118

Feifei Song, Xiaojing Chen, Tao Zhang, Xuedong Tang, Xiaodong Cheng

Aim

Low-grade serous ovarian cancer (LGSOC) is a rare subtype of ovarian cancer with distinct biological behavior. This study aimed to identify new biomarkers with potential diagnostic and prognostic value for LGSOC.

Methods

Gene-expression data were downloaded from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) were identified using R. Functional enrichment analyses were conducted to determine the biological functions and signaling pathways associated with DEGs. The mitogen-activated protein kinase (MAPK) pathway-related gene, chromosome 1 open reading frame 106 (C1orf106), was selected as the target gene. Immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to verify its expression. Associations between C1orf106 expression and the clinical features of patients were analyzed using the chi-square (χ²) test. Prognostic significance was evaluated with survival analyses.

Results

A total of 3099 upregulated and 4968 downregulated genes were identified in LGSOC. Gene set enrichment analysis (GSEA) demonstrated significant alterations in KRAS signaling and metabolic pathways between LGSOC and healthy controls. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses revealed enrichment in immune response and MAPK pathway alterations. Immunohistochemistry and qRT-PCR confirmed that C1orf106 expression in LGSOC tissues was significantly higher than in normal ovarian tissues. Clinically, high C1orf106 expression was associated with lower BMI (< 25 kg/m²), the absence of visible residual disease, and improved progression-free survival (PFS) and overall survival (OS) in univariate Cox and Kaplan–Meier analyses.

Conclusions

C1orf106 may serve as a promising marker for the diagnosis and prognosis of LGSOC.

目的：低级别浆液性卵巢癌（LGSOC）是一种罕见的卵巢癌亚型，具有独特的生物学行为。本研究旨在寻找对LGSOC具有潜在诊断和预后价值的新生物标志物。方法：从Gene Expression Omnibus （GEO）下载基因表达数据。差异表达基因（differential expressed genes, deg）通过功能富集分析确定了与deg相关的生物学功能和信号通路。选择丝裂原活化蛋白激酶（MAPK）通路相关基因1号染色体开放阅读框106 （C1orf106）作为靶基因。免疫组织化学和定量实时聚合酶链反应（qRT-PCR）验证其表达。采用χ2检验分析C1orf106表达与患者临床特征的相关性。通过生存分析评估预后意义。结果：在LGSOC中共鉴定出3099个上调基因和4968个下调基因。基因集富集分析（GSEA）表明，在LGSOC和健康对照之间，KRAS信号和代谢途径发生了显著变化。京都基因和基因组百科全书（KEGG）和基因本体（GO）分析显示免疫反应和MAPK通路改变富集。免疫组织化学和qRT-PCR证实，C1orf106在LGSOC组织中的表达明显高于正常卵巢组织。在临床上，在单变量Cox和Kaplan-Meier分析中，高C1orf106表达与较低的BMI(2)、没有可见的残留疾病、改善的无进展生存期（PFS）和总生存期（OS）相关。结论：C1orf106可作为LGSOC的诊断和预后指标。

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引用次数: 0

Letter to “Etiologies and clinical characteristics of primary amenorrhea: A study from a quaternary care hospital in southern Thailand” 致“原发性闭经的病因和临床特征：来自泰国南部一家四级护理医院的研究”的信。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-21 DOI: 10.1111/jog.70086

Lianyi Bao, Guangbin Yu

引用次数: 0

Clinical Utility of the REM Score in Stratifying Endometrial Malignancy Risk: Insights From a Tertiary Care Centre in South India 快速眼动评分在子宫内膜恶性肿瘤风险分层中的临床应用：来自印度南部三级保健中心的见解。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-21 DOI: 10.1111/jog.70108

K. M. Ashika, D. Jayalakshmi, P. Veena, H. Nandeesha

Objective

To evaluate the performance of the risk of endometrial malignancy (REM) scoring system using its existing cut-off value (0.3185) in stratifying risk for endometrial malignancy and to determine an optimal cut-off value in a tertiary care setting in South India.

Methods

This cross-sectional diagnostic accuracy study enrolled 220 women aged 40–80 years who underwent surgical interventions for abnormal uterine bleeding (AUB), postmenopausal bleeding (PMB), or ultrasonographic abnormalities. Data on clinical, ultrasonographic, and biochemical parameters (including HE4 levels) were collected, and REM scores were calculated. Histopathological outcomes served as the gold standard for assessing performance.

Results

The median REM score was significantly higher in women with malignancy (0.5581, IQR: 0.3442–0.7489) compared to those without (0.1709, IQR: 0.0993–0.3628, p < 0.001). At the existing cut-off value (0.3185), the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were 79.6%, 72.67%, 51.65%, and 90.7%, respectively. An optimal cut-off value of 0.3348 demonstrated improved sensitivity and specificity in the study population.

Conclusion

The REM scoring system effectively stratifies patients at high risk for endometrial malignancy. Adjusting the cut-off value for this population may further enhance its diagnostic utility.

目的：评估子宫内膜恶性肿瘤（REM）评分系统使用其现有的临界值（0.3185）在子宫内膜恶性肿瘤风险分层中的表现，并确定在印度南部三级医疗机构的最佳临界值。方法：这项横断面诊断准确性研究纳入了220名年龄在40-80岁之间的女性，她们因子宫异常出血（AUB）、绝经后出血（PMB）或超声检查异常而接受了手术干预。收集临床、超声、生化指标（含HE4水平）数据，计算REM评分。组织病理学结果是评估表现的金标准。结果：恶性子宫内膜癌患者的REM评分中位数（0.5581,IQR: 0.3442 ~ 0.7489）明显高于非恶性子宫内膜癌患者（0.1709,IQR: 0.0993 ~ 0.3628, p）。调整这一人群的临界值可以进一步提高其诊断效用。

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引用次数: 0

Preoperative Diagnosis of Small Bowel Metastasis of Ovarian Clear Cell Carcinoma Using Capsule and Double-Balloon Endoscopy: A Case Report 卵巢透明细胞癌术前应用胶囊及双球囊内镜诊断小肠转移1例。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-21 DOI: 10.1111/jog.70116

Miku Takadera, Yoshifumi Takahashi, Miki Shinohara, Kohei Tamura, Yuji Takei, Hiroyuki Fujiwara

We present a rare case of small bowel metastasis of ovarian clear cell carcinoma, successfully diagnosed preoperatively using capsule and double-balloon endoscopy. The patient was a 62-year-old woman who underwent primary surgery for stage IIB ovarian clear cell carcinoma followed by six cycles of adjuvant chemotherapy. Six years later, she developed iron-deficiency anemia with melena, but conventional upper and lower endoscopy failed to identify the source of bleeding. Subsequent capsule endoscopy revealed a tumor in the distal ileum, and a biopsy was taken using double-balloon endoscopy. Pathological and immunohistochemical findings supported a diagnosis of recurrent ovarian clear cell carcinoma. Surgical resection was performed, followed by chemotherapy, and the patient remains recurrence-free. This is the first case of small bowel metastasis of ovarian clear cell carcinoma diagnosed preoperatively with endoscopic biopsy. It highlights the criticality of advanced endoscopic modalities for evaluating unexplained anemia in patients with a history of ovarian cancer.

我们报告一例罕见的卵巢透明细胞癌发生小肠转移的病例，术前应用囊腔及双球囊内镜成功诊断。患者是一名62岁的女性，她接受了IIB期卵巢透明细胞癌的原发性手术，随后进行了6个周期的辅助化疗。六年后，她发展为缺铁性贫血并黑黑，但常规的上下内窥镜检查未能确定出血的来源。随后的胶囊内窥镜检查显示回肠远端有肿瘤，并采用双球囊内窥镜进行活检。病理和免疫组织化学结果支持复发性卵巢透明细胞癌的诊断。手术切除，随后化疗，病人仍然没有复发。这是第一例卵巢透明细胞癌的小肠转移术前内镜活检诊断。它强调了评估卵巢癌病史患者不明原因贫血的先进内镜模式的重要性。

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引用次数: 0

Treatment-Seeking Behaviors Among Japanese Working Women With Menopausal Symptoms 有更年期症状的日本职业女性寻求治疗的行为

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-21 DOI: 10.1111/jog.70120

Riyo Kinouchi, Takeshi Iwasa, Hiroshi Ishikawa, Hirokazu Uemura, Toshifumi Takahashi, Yoshiko Mochizuki, Kaori Koga, Seiichiro Tateishi, Yoshihisa Fujino, Shigeo Horie, Toshiyuki Yasui

Aim

Menopausal symptoms affect work performance and the occurrence of presenteeism and absenteeism. However, how well these women cope with menopausal symptoms and whether they receive appropriate treatment remains unclear. In this study, we examined Japanese working women with respect to menopausal symptoms, whether they used medical facilities and which departments they visited, and their satisfaction with the treatment they received.

Methods

An online survey was conducted in Japan. A total of 1031 working women with menopausal symptoms, aged between 40 and 59 years, were recruited. We used an original questionnaire that included items on the participants' demographic characteristics, coping behaviors for menopausal symptoms, the clinical department they visited, and their satisfaction. Menopausal symptoms were assessed using the Menopausal Rating Scale.

Results

The proportion of women with moderate-to-severe menopausal symptoms was 58.4%; 46.8% had somatic symptoms, 61.0% had psychological symptoms, and 28.4% had urogenital symptoms. The proportion of women with moderate-to-severe hot flashes was 16.5%. Among the study population, 45.5% could not cope with their menopausal symptoms. Among women who were coping well with menopausal symptoms, 44.1% visited medical facilities, and 63.6% visited a gynecologist. The respondents' satisfaction rate with their gynecologist was 68.8%.

Conclusions

Among working women with menopausal symptoms, more than 50% had moderate or severe symptoms, and ~50% were coping well with menopausal symptoms. Many working women were likely to visit gynecologists. These results highlight the importance of supporting middle-aged women.

目的：绝经期症状影响工作绩效和出勤缺勤的发生。然而，这些女性如何应对更年期症状以及是否接受了适当的治疗仍不清楚。在这项研究中，我们调查了日本职业妇女的更年期症状，她们是否使用医疗设施，她们去了哪些部门，以及她们对所接受的治疗的满意度。方法：在日本进行在线调查。总共招募了1031名年龄在40至59岁之间有更年期症状的职业妇女。我们使用了一份原始问卷，其中包括参与者的人口统计学特征、对更年期症状的应对行为、他们去过的临床科室以及他们的满意度。使用绝经期评定量表评估绝经期症状。结果：出现中重度更年期症状的妇女占58.4%；46.8%有躯体症状，61.0%有心理症状，28.4%有泌尿生殖症状。中度至重度潮热的女性比例为16.5%。在研究人群中，45.5%的人无法应对她们的更年期症状。在应对更年期症状良好的妇女中，44.1%的人去了医疗机构，63.6%的人去看了妇科医生。受访者对妇科医生的满意度为68.8%。结论：在有更年期症状的职业妇女中，50%以上有中度或重度症状，约50%的妇女能很好地应对更年期症状。许多职业女性可能会去看妇科医生。这些结果突出了支持中年妇女的重要性。

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引用次数: 0

Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients 结合甲状腺自身抗体与CA125提高卵巢子宫内膜异位症的诊断准确性：一项885例患者的回顾性研究

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-15 DOI: 10.1111/jog.70111

Yufeng Wang, Zhiruo Qiu, Yuan Yao, Jie Tan, Xuan Che

Aim

This study aimed to compare clinical characteristics and evaluate diagnostic biomarkers in ovarian endometriosis, with a focus on thyroid autoimmunity associations.

Methods

A retrospective analysis of 885 patients (441 ovarian endometriosis cases; 444 benign ovarian tumor controls) was conducted. Clinical parameters, thyroid function markers (FT3, FT4, TSH), thyroid autoantibodies (TPOAb, TGAb), and CA125 levels were analyzed. Multivariate regression and ROC curves assessed diagnostic utility.

Results

Ovarian endometriosis patients exhibited higher dysmenorrhea prevalence (49.7% vs. 15.3%, p < 0.001), bilateral cysts (26.1% vs. 8.8%, p < 0.001), endometrial polyps (21.9% vs. 15.9%, p = 0.015), and uterine fibroids (35.6% vs. 26.2%, p = 0.003) versus controls. Elevated CA125 (75.3% vs. 10.8%), TPOAb (56.9% vs. 6.5%), and TGAb (68.5% vs. 12.4%) incidences were observed in endometriosis (p < 0.001). Autoimmune thyroid disease co-occurrence was significantly higher in cases (51% vs. 15%, p < 0.001). Multivariate analysis identified CA125 (OR = 18.4, 95% CI: 12.5–27.6), TPOAb (OR = 2.63, 95% CI: 1.46–4.77), and TGAb (OR = 4.03, 95% CI: 2.48–6.60) as independent risk factors (p ≤ 0.001). ROC analysis revealed AUCs of 0.895 (CA125), 0.793 (TGAb), and 0.736 (TPOAb); their combination achieved superior diagnostic accuracy (AUC = 0.924, sensitivity 88.9%, specificity 84.5%).

Conclusion

This large-scale retrospective analysis demonstrates that the integration of serum CA125 with thyroid autoantibodies (TPOAb/TGAb) generates a synergistic diagnostic signature for ovarian endometriosis, achieving unprecedented discriminative accuracy (AUC 0.924) that significantly surpasses individual biomarker testing. The > 3-fold elevated co-occurrence of autoimmune thyroid dysfunction in cases reinforces an underrecognized immune-endocrine interplay in disease pathogenesis. These findings support incorporating thyroid autoimmunity screening into standard diagnostic workups to optimize risk stratification and personalized management pathways for symptomatic patients.

目的：本研究旨在比较卵巢子宫内膜异位症的临床特征和评估诊断生物标志物，重点关注甲状腺自身免疫的相关性。方法：对885例卵巢子宫内膜异位症患者（441例，良性卵巢肿瘤对照444例）进行回顾性分析。分析临床参数、甲状腺功能指标（FT3、FT4、TSH）、甲状腺自身抗体（TPOAb、TGAb）、CA125水平。多变量回归和ROC曲线评估诊断效用。结论：这项大规模的回顾性分析表明，血清CA125与甲状腺自身抗体（TPOAb/TGAb）的结合可产生卵巢子宫内膜异位症的协同诊断特征，具有前所未有的鉴别准确性（AUC 0.924），显著优于个体生物标志物检测。在病例中，自身免疫性甲状腺功能障碍的> 3倍升高，强化了疾病发病机制中未被充分认识的免疫-内分泌相互作用。这些发现支持将甲状腺自身免疫筛查纳入标准诊断检查，以优化有症状患者的风险分层和个性化管理途径。

{"title":"Integrating Thyroid Autoantibodies With CA125 Enhances Diagnostic Precision for Ovarian Endometriosis: A Retrospective Study of 885 Patients","authors":"Yufeng Wang, Zhiruo Qiu, Yuan Yao, Jie Tan, Xuan Che","doi":"10.1111/jog.70111","DOIUrl":"10.1111/jog.70111","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to compare clinical characteristics and evaluate diagnostic biomarkers in ovarian endometriosis, with a focus on thyroid autoimmunity associations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis of 885 patients (441 ovarian endometriosis cases; 444 benign ovarian tumor controls) was conducted. Clinical parameters, thyroid function markers (FT3, FT4, TSH), thyroid autoantibodies (TPOAb, TGAb), and CA125 levels were analyzed. Multivariate regression and ROC curves assessed diagnostic utility.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Ovarian endometriosis patients exhibited higher dysmenorrhea prevalence (49.7% vs. 15.3%, <i>p</i> < 0.001), bilateral cysts (26.1% vs. 8.8%, <i>p</i> < 0.001), endometrial polyps (21.9% vs. 15.9%, <i>p</i> = 0.015), and uterine fibroids (35.6% vs. 26.2%, <i>p</i> = 0.003) versus controls. Elevated CA125 (75.3% vs. 10.8%), TPOAb (56.9% vs. 6.5%), and TGAb (68.5% vs. 12.4%) incidences were observed in endometriosis (<i>p</i> < 0.001). Autoimmune thyroid disease co-occurrence was significantly higher in cases (51% vs. 15%, <i>p</i> < 0.001). Multivariate analysis identified CA125 (OR = 18.4, 95% CI: 12.5–27.6), TPOAb (OR = 2.63, 95% CI: 1.46–4.77), and TGAb (OR = 4.03, 95% CI: 2.48–6.60) as independent risk factors (<i>p</i> ≤ 0.001). ROC analysis revealed AUCs of 0.895 (CA125), 0.793 (TGAb), and 0.736 (TPOAb); their combination achieved superior diagnostic accuracy (AUC = 0.924, sensitivity 88.9%, specificity 84.5%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This large-scale retrospective analysis demonstrates that the integration of serum CA125 with thyroid autoantibodies (TPOAb/TGAb) generates a synergistic diagnostic signature for ovarian endometriosis, achieving unprecedented discriminative accuracy (AUC 0.924) that significantly surpasses individual biomarker testing. The > 3-fold elevated co-occurrence of autoimmune thyroid dysfunction in cases reinforces an underrecognized immune-endocrine interplay in disease pathogenesis. These findings support incorporating thyroid autoimmunity screening into standard diagnostic workups to optimize risk stratification and personalized management pathways for symptomatic patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12527647/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed Administration of Carboprost Methylate Reduces Perioperative Complications Without Affecting Cervical Ripening Effect in Surgical Abortion: A Randomized Controlled Trial 延迟给予甲基卡前列素可减少手术流产围手术期并发症而不影响宫颈成熟效果：一项随机对照试验。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-14 DOI: 10.1111/jog.70107

Yifei Zhao, Wei Xue, Weilin Chen, Duoduo Zhang

Aim

This study aimed to investigate whether optimizing the timing of vaginal administration of carboprost methylate (CM), a prostaglandin F2α analogue, could ensure surgical safety and effectiveness while minimizing its side effects.

Methods

This randomized controlled trial included 120 patients undergoing surgical abortion who were equally divided into two groups in a tertiary hospital. Group A received CM about 2 h before surgery, while group B received the medication just before anesthesia. The primary outcome was the cervical dilation time and the secondary outcomes included parameters of surgery completeness (surgery time, blood loss, and first-pass success rate of 7.5 Hegar dilator) and adverse events (abdominal pain, vomiting, nausea, diarrhea, defecation urgency, and fever).

Results

The cervical dilation time and parameters of surgery completeness were similar between the two groups, and the concentration of cervical matrix metalloproteinase was no different. However, adverse events related to CM were significantly lower in group B than in group A (93.4% vs. 28.8%, p < 0.01) before anesthesia. The abdominal pain numerical rating scale (NRS) score before anesthesia was 10 times higher in group A (2.84 ± 2.11 vs. 0.27 ± 0.53, p < 0.01). Postoperative vomiting and nausea (PONV) percentage were significantly lower in group B (6.7% vs. 19.0%, p = 0.04).

Conclusion

Delayed administration of CM until before anesthesia is effective in cervical priming for surgical abortion in early pregnancy and significantly reduces adverse symptoms, including PONV, diarrhea, and abdominal pain.

Trial Registration

ClinicalTrials.gov: NCT05834361

目的：探讨前列腺素F2α类似物甲基化卡前列素（carboprost methylate， CM）阴道给药时机的优化是否能确保手术安全性和有效性，同时将其副作用降至最低。方法：选取某三级医院手术流产患者120例，随机分为两组。A组在术前约2h给予CM， B组在麻醉前给予CM。主要终点是宫颈扩张时间，次要终点包括手术完成度参数（手术时间、出血量、7.5 Hegar扩张器的一次通过成功率）和不良事件（腹痛、呕吐、恶心、腹泻、排便急促和发烧）。结果：两组宫颈扩张时间、手术完成度参数相似，宫颈基质金属蛋白酶浓度无明显差异。然而，与CM相关的不良事件在B组明显低于A组（93.4%比28.8%）。结论：在麻醉前延迟给药CM对早期妊娠手术流产的宫颈启动有效，并显著减少不良症状，包括PONV、腹泻和腹痛。试验注册：ClinicalTrials.gov: NCT05834361。

{"title":"Delayed Administration of Carboprost Methylate Reduces Perioperative Complications Without Affecting Cervical Ripening Effect in Surgical Abortion: A Randomized Controlled Trial","authors":"Yifei Zhao, Wei Xue, Weilin Chen, Duoduo Zhang","doi":"10.1111/jog.70107","DOIUrl":"10.1111/jog.70107","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study aimed to investigate whether optimizing the timing of vaginal administration of carboprost methylate (CM), a prostaglandin F2α analogue, could ensure surgical safety and effectiveness while minimizing its side effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This randomized controlled trial included 120 patients undergoing surgical abortion who were equally divided into two groups in a tertiary hospital. Group A received CM about 2 h before surgery, while group B received the medication just before anesthesia. The primary outcome was the cervical dilation time and the secondary outcomes included parameters of surgery completeness (surgery time, blood loss, and first-pass success rate of 7.5 Hegar dilator) and adverse events (abdominal pain, vomiting, nausea, diarrhea, defecation urgency, and fever).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The cervical dilation time and parameters of surgery completeness were similar between the two groups, and the concentration of cervical matrix metalloproteinase was no different. However, adverse events related to CM were significantly lower in group B than in group A (93.4% vs. 28.8%, <i>p</i> < 0.01) before anesthesia. The abdominal pain numerical rating scale (NRS) score before anesthesia was 10 times higher in group A (2.84 ± 2.11 vs. 0.27 ± 0.53, <i>p</i> < 0.01). Postoperative vomiting and nausea (PONV) percentage were significantly lower in group B (6.7% vs. 19.0%, <i>p</i> = 0.04).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Delayed administration of CM until before anesthesia is effective in cervical priming for surgical abortion in early pregnancy and significantly reduces adverse symptoms, including PONV, diarrhea, and abdominal pain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov: NCT05834361</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 10","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long Term Disease Control of Brain Metastases From Chemotherapy-Resistant Endometrial Cancer With Lenvatinib and Pembrolizumab: A Case Report Lenvatinib和Pembrolizumab对化疗耐药子宫内膜癌脑转移的长期疾病控制：一例报告

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-14 DOI: 10.1111/jog.70102

Ayaka Fujioka, Akimasa Takahashi, Tsukuru Amano, Yuji Tanaka, Yutaka Yoneoka, Shunichiro Tsuji

Brain metastases from endometrial carcinoma are extremely rare and associated with poor prognosis. We present a 43-year-old woman with mismatch repair deficient endometrial cancer who developed multiple brain metastases refractory to cytotoxic chemotherapy and without extracranial involvement. After stereotactic radiotherapy, combination therapy with lenvatinib and pembrolizumab resulted in sustained partial remission for 16 months, with no evidence of brain hemorrhage. This case demonstrates that lenvatinib plus pembrolizumab may offer an effective and safe therapeutic option for brain metastases from endometrial cancer, even in patients resistant to conventional therapy. Remarkably, this outcome challenges the traditionally poor prognosis of such cases and underscores the potential for novel targeted and immunotherapeutic strategies to redefine the standard of care for this rare and devastating complication.

子宫内膜癌脑转移极为罕见，且预后较差。我们报告一位43岁的女性，她患有错配修复缺陷的子宫内膜癌，她发生了多发性脑转移，对细胞毒性化疗无效，没有颅内外受累。立体定向放疗后，lenvatinib和pembrolizumab联合治疗导致持续16个月的部分缓解，无脑出血的证据。该病例表明，lenvatinib + pembrolizumab可能为子宫内膜癌脑转移提供一种有效且安全的治疗选择，即使对传统治疗有耐药性的患者也是如此。值得注意的是，这一结果挑战了这类病例传统的不良预后，并强调了新的靶向和免疫治疗策略的潜力，以重新定义这种罕见和破坏性并发症的护理标准。

引用次数: 0

Maternal Death due to Complications Related to Labor Analgesia: Report From Maternal Death Exploratory Committee in Japan 分娩镇痛相关并发症导致的产妇死亡：来自日本产妇死亡调查委员会的报告

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-14 DOI: 10.1111/jog.70103

Junichi Hasegawa, Hiroaki Tanaka, Kayo Tanaka, Tatsuya Arakaki, Masamitsu Nakamura, Rie Kato, Toshiyuki Okutomi, Hiroyuki Sumikura, Masahiko Nakata, Takeshi Murakoshi, Akihiko Sekizawa, Akihito Nakai, Isamu Ishiwata, Tomoaki Ikeda

Objectives

To clarify the causes of maternal death due to complications related to labor analgesia.

Methods

A nationwide retrospective study was conducted to investigate intrapartum maternal deaths in Japan between 2010 and 2022. The obstetric and anesthetic characteristics of women with (cases) and without (controls) labor analgesia were compared.

Results

Of the 558 maternal deaths in Japan during the study period, 161 occurred intrapartum. Among these, 24 (15%) patients received labor analgesia (cases), 117 did not receive labor analgesia (controls), and 20 underwent elective cesarean section. Regarding the causes of maternal death, the incidence of amniotic fluid embolism was 71% among the cases and 56% among the controls. The incidence of uterine rupture/laceration was 13% among the cases and 9% among the controls (nonsignificant difference). Moreover, among the patients who received labor analgesia, there were two cases of maternal deaths directly related to neuraxial labor analgesia (due to high spinal anesthesia and local anesthetic toxicity). Induction of labor was attempted in 96% of the cases with labor analgesia compared to 55% of the controls (p < 0.01).

Conclusion

Among the cases of maternal deaths, amniotic fluid embolism, uterine rupture/laceration, and complications of the labor analgesia itself were likely causes in patients who had received labor analgesia. These results may be related to the higher frequency of induction of labor in labor analgesia.

目的：明确分娩镇痛相关并发症导致产妇死亡的原因。方法：对2010年至2022年日本产时产妇死亡情况进行全国性回顾性研究。比较（病例）和（对照组）分娩镇痛妇女的产科和麻醉特点。结果：在研究期间日本558例产妇死亡中，161例发生在分娩时。其中24例（15%）患者接受了分娩镇痛（例），117例（对照组）患者未接受分娩镇痛，20例患者接受了择期剖宫产。关于产妇死亡的原因，羊水栓塞的发生率在病例中为71%，在对照组中为56%。子宫破裂/撕裂的发生率为13%，对照组为9%（差异无统计学意义）。此外，在接受分娩镇痛的患者中，有2例产妇死亡与神经轴分娩镇痛直接相关（由于高腰麻和局麻毒性）。与55%的对照组相比，96%的分娩镇痛患者尝试引产(p结论：在产妇死亡病例中，羊水栓塞、子宫破裂/撕裂以及分娩镇痛本身的并发症是分娩镇痛患者可能的原因。这些结果可能与分娩镇痛时引产频率较高有关。

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引用次数: 0

Study on the Correlation Between Breast Milk Immune Factors and Neonatal Immune Development and the Prevention of Allergic Diseases 母乳免疫因子与新生儿免疫发育及过敏性疾病预防的相关性研究。

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2025-10-13 DOI: 10.1111/jog.70104

Ying Cheng, Yi Tai, Liuyuan Ge, Xingshuo Qiu, Jiayin Wang, Yujuan Chang

Aim

This study investigates the longitudinal correlations between immune constituents of human breast milk and potential allergy protection in the neonatal immune system, focusing on immunoglobulins, cytokines, and microbial composition. It has been hypothesized that specific immune components in breast milk are associated with neonatal immune maturation and a reduced incidence of early allergic manifestations.

Methods

A prospective descriptive observational cohort study was conducted with 120 mother-neonate dyads. Breast milk and blood samples were collected at multiple time points within 6 months postpartum. Immunoglobulins (IgA), cytokines (TGF-β), lactoferrin, and microbial composition were quantified. Neonatal immune markers, including CD4+ and CD8+ T lymphocytes, were measured. Maternal factors such as age, dietary intake, and allergy history were analyzed for their impact on breast milk composition and neonatal immune development.

Results

Immune factors in breast milk, including IgA, lactoferrin, and TGF-β, demonstrated a declining trend over time, while neonatal circulating CD4+ and CD8+ T lymphocytes increased, indicating immune system maturation. Maternal characteristics such as age, diet, and allergies were significantly associated with breast milk composition changes, influencing neonatal immune responses. Microbial diversity in breast milk also varied across time points, suggesting potential effects on immune tolerance development.

Conclusions

The study highlights the crucial role of breast milk in shaping neonatal immune tolerance and reducing allergy risk during infancy. Maternal health, nutrition, and allergic conditions significantly influence breast milk composition, thereby impacting neonatal immune development. These findings emphasize the importance of maternal well-being and breastfeeding in promoting infant immune health.

目的：本研究探讨母乳免疫成分与新生儿免疫系统中潜在的过敏保护之间的纵向相关性，重点关注免疫球蛋白、细胞因子和微生物组成。据推测，母乳中的特定免疫成分与新生儿免疫成熟和早期过敏表现发生率降低有关。方法：对120对母子进行前瞻性描述性观察队列研究。在产后6个月内的多个时间点采集母乳和血液样本。定量免疫球蛋白（IgA）、细胞因子（TGF-β）、乳铁蛋白和微生物组成。测定新生儿免疫标志物，包括CD4+和CD8+ T淋巴细胞。分析了年龄、饮食摄入和过敏史等母体因素对母乳成分和新生儿免疫发育的影响。结果：母乳中IgA、乳铁蛋白、TGF-β等免疫因子随着时间的推移呈下降趋势，新生儿循环CD4+、CD8+ T淋巴细胞增加，表明免疫系统成熟。母亲的年龄、饮食和过敏等特征与母乳成分变化显著相关，从而影响新生儿的免疫反应。母乳中的微生物多样性也随着时间点的变化而变化，这表明对免疫耐受的发展有潜在的影响。结论：该研究强调了母乳在塑造新生儿免疫耐受性和降低婴儿过敏风险方面的关键作用。产妇健康、营养和过敏状况显著影响母乳成分，从而影响新生儿免疫发育。这些发现强调了孕产妇健康和母乳喂养在促进婴儿免疫健康方面的重要性。

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引用次数: 0