Journal of Obstetrics and Gynaecology Research最新文献_第8页

Tadalafil suppresses LPS-induced inflammation and improves pregnancy outcomes in a pregnant mouse model

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-29 DOI: 10.1111/jog.16196

Kento Yoshikawa-Terada, Erina Takayama, Midori Uemura, Kuniaki Toriyabe, Ryota Tachibana, Hideaki Yajima, Tomoaki Ikeda, Eiji Kondo, Hiroki Takeuchi

Aim

This study investigated the efficacy of tadalafil in reducing inflammation and improving pregnancy outcomes in an lipopolysaccharide (LPS)-induced mouse model of perinatal complications.

Methods

Pregnant C57BL/6J mice were divided into three groups: control (C), LPS (L), and LPS + tadalafil (LT). The LT group received tadalafil from 10 days post-coitum (dpc), and LPS was administered intraperitoneally to the L and LT groups at 11 dpc. Mice were sacrificed 2 h post-injection for inflammatory marker analysis, with plasma and placentas collected. Remaining mice were sacrificed at 14 dpc to assess miscarriage and FGR. Placental damage was scored, cytokine levels measured by ELISA, and TNFα and NF-κB expression examined via immunohistochemistry.

Results

Fetal weight was significantly lower in the L and LT groups compared to the C group, with the LT group showing a significant increase compared to the L group. Absorption rates were significantly higher in the L group compared to the C and LT groups. At 14 dpc, placental necrosis scores were significantly higher in the L and LT groups than in the C group, while the LT group showed a significant decrease compared to the L group. Plasma inflammatory cytokine levels (TNF-α, IL-1β, IL-6) were significantly elevated following LPS administration but reduced with tadalafil treatment. Additionally, TNF-α expression and NF-κB activity in the placenta were significantly higher in the L group compared to the C and LT groups.

Conclusions

Tadalafil reduced inflammation and improved pregnancy outcomes, suggesting its potential for managing inflammation-related perinatal complications.

{"title":"Tadalafil suppresses LPS-induced inflammation and improves pregnancy outcomes in a pregnant mouse model","authors":"Kento Yoshikawa-Terada, Erina Takayama, Midori Uemura, Kuniaki Toriyabe, Ryota Tachibana, Hideaki Yajima, Tomoaki Ikeda, Eiji Kondo, Hiroki Takeuchi","doi":"10.1111/jog.16196","DOIUrl":"https://doi.org/10.1111/jog.16196","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>This study investigated the efficacy of tadalafil in reducing inflammation and improving pregnancy outcomes in an lipopolysaccharide (LPS)-induced mouse model of perinatal complications.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Pregnant C57BL/6J mice were divided into three groups: control (C), LPS (L), and LPS + tadalafil (LT). The LT group received tadalafil from 10 days post-coitum (dpc), and LPS was administered intraperitoneally to the L and LT groups at 11 dpc. Mice were sacrificed 2 h post-injection for inflammatory marker analysis, with plasma and placentas collected. Remaining mice were sacrificed at 14 dpc to assess miscarriage and FGR. Placental damage was scored, cytokine levels measured by ELISA, and TNFα and NF-κB expression examined via immunohistochemistry.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fetal weight was significantly lower in the L and LT groups compared to the C group, with the LT group showing a significant increase compared to the L group. Absorption rates were significantly higher in the L group compared to the C and LT groups. At 14 dpc, placental necrosis scores were significantly higher in the L and LT groups than in the C group, while the LT group showed a significant decrease compared to the L group. Plasma inflammatory cytokine levels (TNF-α, IL-1β, IL-6) were significantly elevated following LPS administration but reduced with tadalafil treatment. Additionally, TNF-α expression and NF-κB activity in the placenta were significantly higher in the L group compared to the C and LT groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Tadalafil reduced inflammation and improved pregnancy outcomes, suggesting its potential for managing inflammation-related perinatal complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143120434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to Humans-written versus ChatGPT-generated case reports 致人类的信-书面与chatgpt生成的病例报告。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-26 DOI: 10.1111/jog.16195

Shunsuke Koga, Wei Du

引用次数: 0

A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women 一项比较卡贝菌素和催产素预防低危妇女剖宫产后产后出血的随机试验的系统回顾和荟萃分析。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-25 DOI: 10.1111/jog.16194

Ahmed M. Maged, Nour A. El-Goly, Doaa Turki, Nehal Bassiouny, Nihal El-Demiry

<div> <section> <h3> Objectives</h3> <p>To evaluate the efficacy and safety of Carbetocin compared to oxytocin in prevention of postpartum hemorrhage (PPH) after low-risk cesarean delivery (CD).</p> </section> <section> <h3> Search Strategy</h3> <p>Screening of Medline, Web Of Science, Scopus, Google scholar, and clinical trials registry till January 2024 using the key words related to carbetocin, blood loss, PPH, Cesarean section and their MeSH terms was done.</p> </section> <section> <h3> Selection Criteria</h3> <p>This study included all RCTs conducted on women with low risk for developing PPH after CD and compared the administration of carbetocin to oxytocin without any language limitation. These studies compared carbetocin to oxytocin alone or oxytocin combined with misoprostol. The review included all doses and routes of carbetocin and oxytocin administration.</p> </section> <section> <h3> Data Collection and Analysis</h3> <p>The extracted data included study settings, the participants' size and characteristics, intervention details of both the study and control groups especially data about the dose route and timing of drug administration, the outcome parameters and trial registration details The reported outcomes included the requirement of additional uterotonic agents or blood transfusion, the difference between preoperative and postoperative hemoglobin, the occurrence of PPH, blood loss and drug adverse effects.</p> </section> <section> <h3> Main Results</h3> <p>Seventeen studies including 3667 participants were included. The need for additional uterotonic agents was evaluated in 14 studies with 3154 participants and revealed an OR of 0.53 with 95% CI of 0.39 and 0.72 (<i>p</i> < 0.001, <i>I</i><sup>2</sup> 41%). The incidence of PPH was reported in 11 studies with 2228 participants and revealed an Odd ratio of 1.08 with 95%CI of [0.81, 1.44] (<i>p</i> = 0.61, <i>I</i><sup>2</sup> 0%). The hemoglobin drop after the operation was evaluated in 3 studies with 1240 participants and revealed an MD of −0.08 with 95% CI of −0.10 and − 0.06 (<i>p</i> < 0.001, <i>I</i><sup>2</sup> 0%). The need for blood transfusion was evaluated in 9 studies with 1936 participants and revealed an OR of 0.57 with 95% CI of 0.34 and 0.97 (<i>p</i> = 0.04, <i>I</i><sup>2</sup> 0%).</p> </section> <section> <h3> Conclusion</h3> <p>Carbetocin administration during CD in women with low risk for PPH is associated with less need for additional uterotonic agents (moderate evidence), less ne

目的：比较卡贝菌素与催产素预防低危剖宫产（CD）术后产后出血（PPH）的疗效和安全性。检索策略：筛选Medline、Web of Science、Scopus、谷歌scholar、截止2024年1月的临床试验注册表，使用卡霉素、失血、PPH、剖宫产相关关键词及其MeSH术语。选择标准：本研究纳入了所有在CD后发生PPH的低风险妇女中进行的随机对照试验，并比较了卡贝菌素和催产素的使用，没有任何语言限制。这些研究比较了催产素与单独使用催产素或催产素与米索前列醇联合使用。该综述包括卡贝菌素和催产素给药的所有剂量和途径。数据收集和分析：提取的数据包括研究设置、受试者规模和特征、研究组和对照组的干预细节，特别是给药的给药途径和给药时间、结局参数和试验注册细节。报告的结局包括额外使用子宫强张药物或输血的需求、术前和术后血红蛋白的差异、PPH的发生、失血和药物不良反应。主要结果：纳入17项研究，共3667名受试者。在14项3154名参与者的研究中评估了额外子宫扩张药物的需求，结果显示OR为0.53,95% CI为0.39和0.72 （p = 2.41%）。11项研究共报告了2228名参与者的PPH发病率，奇比为1.08,95%CI为[0.81,1.44]（p = 0.61, i2%）。在3项涉及1240名参与者的研究中评估了手术后的血红蛋白下降，结果显示MD为-0.08,95% CI为-0.10和- 0.06 （p < 2%）。9项研究对1936名参与者进行了输血需求评估，结果显示OR为0.57,95% CI为0.34和0.97 （p = 0.04, i2%）。结论：与未增加不良反应的给予催产素的妇女相比，低PPH风险的妇女在CD期间给予卡贝菌素与较少需要额外的子宫扩张药物（中度证据），较少需要输血（高证据）和较低的血红蛋白下降（高证据）相关。

{"title":"A systematic review and meta-analysis of randomized trials comparing carbetocin to oxytocin in prevention of postpartum hemorrhage after cesarean delivery in low-risk women","authors":"Ahmed M. Maged, Nour A. El-Goly, Doaa Turki, Nehal Bassiouny, Nihal El-Demiry","doi":"10.1111/jog.16194","DOIUrl":"10.1111/jog.16194","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the efficacy and safety of Carbetocin compared to oxytocin in prevention of postpartum hemorrhage (PPH) after low-risk cesarean delivery (CD).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Search Strategy</h3>\u0000 \u0000 <p>Screening of Medline, Web Of Science, Scopus, Google scholar, and clinical trials registry till January 2024 using the key words related to carbetocin, blood loss, PPH, Cesarean section and their MeSH terms was done.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Selection Criteria</h3>\u0000 \u0000 <p>This study included all RCTs conducted on women with low risk for developing PPH after CD and compared the administration of carbetocin to oxytocin without any language limitation. These studies compared carbetocin to oxytocin alone or oxytocin combined with misoprostol. The review included all doses and routes of carbetocin and oxytocin administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Data Collection and Analysis</h3>\u0000 \u0000 <p>The extracted data included study settings, the participants' size and characteristics, intervention details of both the study and control groups especially data about the dose route and timing of drug administration, the outcome parameters and trial registration details The reported outcomes included the requirement of additional uterotonic agents or blood transfusion, the difference between preoperative and postoperative hemoglobin, the occurrence of PPH, blood loss and drug adverse effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Results</h3>\u0000 \u0000 <p>Seventeen studies including 3667 participants were included. The need for additional uterotonic agents was evaluated in 14 studies with 3154 participants and revealed an OR of 0.53 with 95% CI of 0.39 and 0.72 (<i>p</i> < 0.001, <i>I</i><sup>2</sup> 41%). The incidence of PPH was reported in 11 studies with 2228 participants and revealed an Odd ratio of 1.08 with 95%CI of [0.81, 1.44] (<i>p</i> = 0.61, <i>I</i><sup>2</sup> 0%). The hemoglobin drop after the operation was evaluated in 3 studies with 1240 participants and revealed an MD of −0.08 with 95% CI of −0.10 and − 0.06 (<i>p</i> < 0.001, <i>I</i><sup>2</sup> 0%). The need for blood transfusion was evaluated in 9 studies with 1936 participants and revealed an OR of 0.57 with 95% CI of 0.34 and 0.97 (<i>p</i> = 0.04, <i>I</i><sup>2</sup> 0%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Carbetocin administration during CD in women with low risk for PPH is associated with less need for additional uterotonic agents (moderate evidence), less ne","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of transient hyperthyroidism induced by placental site trophoblastic tumor 胎盘部位滋养细胞瘤致短暂性甲状腺功能亢进1例。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-25 DOI: 10.1111/jog.16193

Sumire Ishii, Takashi Hirayama, Harumi Saeki, Kazunari Fujino, Yasuhisa Terao, Atsuo Itakura

We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6 months after delivery. Endometrial histology suggested PSTT. Serum human chorionic gonadotropin (hCG) was 117 mIU/mL and serum estradiol (E2) were 51 pg/mL. She reported increased appetite, sweating, fatigue, and 7-kg weight loss within 3 months. Blood samples showed a thyroid-stimulating hormone (TSH) level <0.01 μIU/mL, FT3: 24.3 pg/mL, FT4: 5.3 ng/mL. The patient was diagnosed with hyperthyroidism. After thyroid function normalized, laparoscopic hysterectomy and bilateral salpingectomy were performed. Two years postsurgery, there was no recurrence, and thyroid function improved. The hCG produced from gestational trophoblastic disease has stronger TSH activity than that from gestational trophoblasts. However, in PSTT, the E2 level, which increases thyroid-binding proteins and suppresses elevated thyroid hormone levels, is low and may induce hyperthyroidism. In cases of suspected PSTT, thyroid function should be evaluated when hyperthyroid symptoms are present.

我们报告一例胎盘部位滋养细胞瘤（PSTT）合并一过性甲状腺功能亢进。一名29岁妊娠2段妇女在分娩后6个月出现异常生殖器出血。子宫内膜组织学提示PSTT。血清人绒毛膜促性腺激素（hCG） 117 mIU/mL，血清雌二醇（E2） 51 pg/mL。她报告食欲增加、出汗、疲劳，3个月内体重减轻7公斤。血液样本显示有促甲状腺激素（TSH）水平

{"title":"A case of transient hyperthyroidism induced by placental site trophoblastic tumor","authors":"Sumire Ishii, Takashi Hirayama, Harumi Saeki, Kazunari Fujino, Yasuhisa Terao, Atsuo Itakura","doi":"10.1111/jog.16193","DOIUrl":"10.1111/jog.16193","url":null,"abstract":"<p>We report a case of placental site trophoblastic tumor (PSTT) with transient hyperthyroidism. A 29-year-old gravida 2 para 2 woman presented with abnormal genital bleeding 6 months after delivery. Endometrial histology suggested PSTT. Serum human chorionic gonadotropin (hCG) was 117 mIU/mL and serum estradiol (E2) were 51 pg/mL. She reported increased appetite, sweating, fatigue, and 7-kg weight loss within 3 months. Blood samples showed a thyroid-stimulating hormone (TSH) level <0.01 μIU/mL, FT3: 24.3 pg/mL, FT4: 5.3 ng/mL. The patient was diagnosed with hyperthyroidism. After thyroid function normalized, laparoscopic hysterectomy and bilateral salpingectomy were performed. Two years postsurgery, there was no recurrence, and thyroid function improved. The hCG produced from gestational trophoblastic disease has stronger TSH activity than that from gestational trophoblasts. However, in PSTT, the E2 level, which increases thyroid-binding proteins and suppresses elevated thyroid hormone levels, is low and may induce hyperthyroidism. In cases of suspected PSTT, thyroid function should be evaluated when hyperthyroid symptoms are present.</p>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthropometric measurements as predictors of nutritional status in black South African women during pregnancy 人体测量作为南非黑人妇女怀孕期间营养状况的预测指标。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-25 DOI: 10.1111/jog.16184

Christen R. Erasmus, Niren R. Maharaj, Anil A. Chuturgoon

Background

Nutritional risk assessment is an essential component of primary health care screening, especially for pregnant women. The aim of this study was to investigate the relationship between maternal body mass index (BMI) and maternal anthropometric measurements in black South African pregnant women, both with and without human immunodeficiency virus (HIV).

Materials and Methods

A cross-sectional observational study design was used. Two hundred black South African pregnant women were recruited of which 90 were HIV-infected and 110 were HIV-uninfected. The anthropometric measurements assessed included mid-upper arm circumference (MUAC), tricep skinfold (TSF), subscapular skinfold (SSF), mid-arm muscle circumference (MAMC), wrist circumference (WC), frame size, and BMI.

Results

Maternal age was significantly associated with changes in maternal anthropometric measurements. Maternal BMI was significantly correlated with other maternal anthropometric measurements including MUAC, TSF, SSF, MAMC, WC, and frame size. The anthropometric measurements that were found to be accurate for assessing obesity in pregnancy included TSF (≥20.75 mm), SSF (≥21.75 mm), MAMC (≥25.23 cm), and WC (≥16.25 cm). Additionally, SSF (≥15.75 mm) and MAMC (≥23.35 cm) could be used to assess for overweight nutritional status. Lastly, frame size could be used to assess for underweight (≥10.05) and normal (≥9.95) nutritional status. No significant anthropometric differences were observed between the HIV-infected pregnant women and the HIV-uninfected pregnant women in this study.

Conclusion

Surrogate anthropometric measurements offer a simple solution for assessing nutritional status in pregnant women. MUAC was the most accurate method for identifying overweight and obesity. Furthermore, maternal HIV status did not affect the anthropometric measurements.

背景：营养风险评估是初级卫生保健筛查的重要组成部分，特别是对孕妇。本研究的目的是调查南非黑人孕妇，无论有无人类免疫缺陷病毒（HIV），母体体重指数（BMI）和母体人体测量测量之间的关系。材料和方法：采用横断面观察性研究设计。招募了200名南非黑人孕妇，其中90人感染艾滋病毒，110人未感染艾滋病毒。评估的人体测量包括上臂中围（MUAC）、三头肌皮褶（TSF）、肩胛下皮褶（SSF）、上臂中肌围（MAMC）、腕部围（WC）、骨架尺寸和BMI。结果：产妇年龄与产妇人体测量值的变化显著相关。母体BMI与其他母体人体测量指标，包括MUAC、TSF、SSF、MAMC、WC和框架尺寸显著相关。准确评估妊娠期肥胖的人体测量指标包括TSF（≥20.75 mm）、SSF（≥21.75 mm）、MAMC（≥25.23 cm）和WC（≥16.25 cm）。此外，SSF（≥15.75 mm）和MAMC（≥23.35 cm）可用于评估超重营养状况。最后，体格大小可用于评估体重不足（≥10.05）和正常（≥9.95）的营养状况。在本研究中，感染hiv的孕妇和未感染hiv的孕妇之间没有观察到显著的人体测量差异。结论：代孕人体测量为评估孕妇的营养状况提供了一种简单的方法。MUAC是识别超重和肥胖最准确的方法。此外，母体的HIV状况并不影响人体测量值。

{"title":"Anthropometric measurements as predictors of nutritional status in black South African women during pregnancy","authors":"Christen R. Erasmus, Niren R. Maharaj, Anil A. Chuturgoon","doi":"10.1111/jog.16184","DOIUrl":"10.1111/jog.16184","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Nutritional risk assessment is an essential component of primary health care screening, especially for pregnant women. The aim of this study was to investigate the relationship between maternal body mass index (BMI) and maternal anthropometric measurements in black South African pregnant women, both with and without human immunodeficiency virus (HIV).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A cross-sectional observational study design was used. Two hundred black South African pregnant women were recruited of which 90 were HIV-infected and 110 were HIV-uninfected. The anthropometric measurements assessed included mid-upper arm circumference (MUAC), tricep skinfold (TSF), subscapular skinfold (SSF), mid-arm muscle circumference (MAMC), wrist circumference (WC), frame size, and BMI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Maternal age was significantly associated with changes in maternal anthropometric measurements. Maternal BMI was significantly correlated with other maternal anthropometric measurements including MUAC, TSF, SSF, MAMC, WC, and frame size. The anthropometric measurements that were found to be accurate for assessing obesity in pregnancy included TSF (≥20.75 mm), SSF (≥21.75 mm), MAMC (≥25.23 cm), and WC (≥16.25 cm). Additionally, SSF (≥15.75 mm) and MAMC (≥23.35 cm) could be used to assess for overweight nutritional status. Lastly, frame size could be used to assess for underweight (≥10.05) and normal (≥9.95) nutritional status. No significant anthropometric differences were observed between the HIV-infected pregnant women and the HIV-uninfected pregnant women in this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Surrogate anthropometric measurements offer a simple solution for assessing nutritional status in pregnant women. MUAC was the most accurate method for identifying overweight and obesity. Furthermore, maternal HIV status did not affect the anthropometric measurements.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11669476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incidence and influencing factors for surgical site infections after cesarean section in China: A systematic review and meta-analysis 中国剖宫产术后手术部位感染的发生率及影响因素：一项系统回顾和荟萃分析。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-23 DOI: 10.1111/jog.16172

Li Guo, Shujuan Huang, Hongmei Sui, Weichao Li

Objective

This study aims to estimate the overall incidence of surgical site infections (SSIs) after cesarean section (CS) and the influencing factors in the Chinese population.

Materials and Methods

The study searched all relevant literature in English and Chinese search databases (English search bases: PubMed, Embase, Cochrane Library, Web of Science; Chinese search bases: China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database) up to March 19, 2024, according to the search strategy. A random/fixed effects model was decided on the basis of the I² statistic assessing the magnitude of study heterogeneity, and publication bias was assessed using the Begg's test.

Results

After the selection, a final selection of 25 articles was involved. The estimate of post-CS SSIs in China was 2.4% (95%CI: 0.019, 0.029). Age ≥30 years (WMD: 3.8), pre-pregnancy body mass index (BMI) ≥25 kg/m² (WMD: 1.8), obesity (odds ratio [OR]: 3.0), vaginal cleanliness 3–4 (OR: 4.2), anemia (OR: 1.4), premature rupture of membranes (OR: 2.6), diabetes mellitus (OR: 2.7), National Nosocomial Infections Surveillance System 1–3 (OR: 5.6), emergency surgery (OR: 2.3), trial of labor (OR: 2.9), duration of surgery ≥60 min (OR: 2.0), and intraoperative blood loss >500 mL (OR: 3.5) were the risk factors for post-CS SSIs.

Conclusions

The rate of post-CS SSIs estimated was 2.4% in China. Both maternal conditions and surgical factors can potentially increase the risk of post-CS SSIs.

目的：本研究旨在了解剖宫产术后手术部位感染（ssi）在中国人群中的总体发生率及其影响因素。材料和方法：在中英文检索数据库中检索所有相关文献(英文检索库：PubMed、Embase、Cochrane Library、Web of Science；中国搜索基地：中国国家知识基础设施、万方、中国科技期刊库)，根据搜索策略截止到2024年3月19日。随机/固定效应模型采用I2统计量评估研究异质性的大小，发表偏倚采用Begg检验评估。结果：经过筛选，最终筛选出25篇文章。中国的cs后ssi估计为2.4% （95%CI: 0.019, 0.029）。年龄≥30岁（WMD: 3.8）、孕前体重指数(BMI)≥25kg /m2 （WMD: 1.8）、肥胖（比值比[OR]: 3.0）、阴道清洁度3-4 （OR: 4.2）、贫血（OR: 1.4）、胎膜早破（OR: 2.6）、糖尿病（OR: 2.7）、国家医院感染监测系统1-3 （OR: 5.6）、急诊手术（OR: 2.3）、分娩试验（OR: 2.9）、手术时间≥60分钟（OR: 2.0）、术中出血量500ml （OR: 3.5）是cs后ssi发生的危险因素。结论：中国cs后ssi发生率估计为2.4%。产妇条件和手术因素都可能增加cs后ssi的风险。

{"title":"Incidence and influencing factors for surgical site infections after cesarean section in China: A systematic review and meta-analysis","authors":"Li Guo, Shujuan Huang, Hongmei Sui, Weichao Li","doi":"10.1111/jog.16172","DOIUrl":"10.1111/jog.16172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aims to estimate the overall incidence of surgical site infections (SSIs) after cesarean section (CS) and the influencing factors in the Chinese population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The study searched all relevant literature in English and Chinese search databases (English search bases: PubMed, Embase, Cochrane Library, Web of Science; Chinese search bases: China National Knowledge Infrastructure, Wanfang, and China Science and Technology Journal Database) up to March 19, 2024, according to the search strategy. A random/fixed effects model was decided on the basis of the <i>I</i><sup>2</sup> statistic assessing the magnitude of study heterogeneity, and publication bias was assessed using the Begg's test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the selection, a final selection of 25 articles was involved. The estimate of post-CS SSIs in China was 2.4% (95%CI: 0.019, 0.029). Age ≥30 years (WMD: 3.8), pre-pregnancy body mass index (BMI) ≥25 kg/m<sup>2</sup> (WMD: 1.8), obesity (odds ratio [OR]: 3.0), vaginal cleanliness 3–4 (OR: 4.2), anemia (OR: 1.4), premature rupture of membranes (OR: 2.6), diabetes mellitus (OR: 2.7), National Nosocomial Infections Surveillance System 1–3 (OR: 5.6), emergency surgery (OR: 2.3), trial of labor (OR: 2.9), duration of surgery ≥60 min (OR: 2.0), and intraoperative blood loss >500 mL (OR: 3.5) were the risk factors for post-CS SSIs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The rate of post-CS SSIs estimated was 2.4% in China. Both maternal conditions and surgical factors can potentially increase the risk of post-CS SSIs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab lenvatinib + pembrolizumab治疗晚期子宫内膜癌的潜在炎症生物标志物。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-23 DOI: 10.1111/jog.16182

Shintaro Yanazume, Yusuke Kobayashi, Yukari Kirita, Ikumi Kitazono, Chikako Nagata, Ayumi Kozai, Akihide Tanimoto, Hiroaki Kobayashi

Introduction

To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib/pembrolizumab (LEN/PEM). The utility of certain inflammatory biomarkers in endometrial liquid-based cytology (LBC) or peripheral blood samples, such as neutrophil counts, lymphocyte counts, and neutrophil-to-lymphocyte ratio (NLR) were explored.

Methods

The study included 25 patients with advanced or recurrent endometrial cancer who had received LEN/PEM between August 2018 and March 2024. Predictors for overall response (OR), disease control, and progression-free survival, based on neutrophil/lymphocyte counts, NLR scores of the endometrial LBC prior to initial treatment, and peripheral blood prior to initial treatment and prior to LEM/PEM treatment were compared using a receiver operating characteristic curve. Significant predictors were evaluated using the log-rank test, and multivariate analysis.

Results

Although neutrophil counts and NLR score in endometrial LBC prior to initial treatment were better effective predictors for OR, the most accurate predictor of a progression-free status was NLR score in peripheral blood prior to LEM/PEM (0.722, 95% CI: 0.45–0.99, sensitivity: 57.1%, specificity: 94.4%). In peripheral blood prior to LEN/PEM, the lower NLR (NLR <5.39) group had a significantly longer PFS than the higher NLR (5.39 ≤ NLR) group (p = 0.023, median survival: 13.5 vs. 3.0 months), and tended to be independently correlated with PFS (hazard ratio = 2.571; 95% CI = 0.857–7.719; p = 0.092).

Conclusion

Inflammatory biomarkers in endometrial LBC failed to predict the efficacy of LEN/PEM, while peripheral blood NLR score sampled prior to LEN/PEM potentially could be a significant predictor.

目的：确定预后生物标志物，以预测患者对lenvatinib/pembrolizumab （LEN/PEM）的反应。探讨了某些炎症生物标志物在子宫内膜液基细胞学（LBC）或外周血样本中的应用，如中性粒细胞计数、淋巴细胞计数和中性粒细胞与淋巴细胞比率（NLR）。方法：该研究纳入了2018年8月至2024年3月期间接受LEN/PEM治疗的25例晚期或复发子宫内膜癌患者。根据中性粒细胞/淋巴细胞计数、初始治疗前子宫内膜LBC NLR评分、初始治疗前和LEM/PEM治疗前的外周血，使用接受者工作特征曲线比较总体缓解（OR）、疾病控制和无进展生存期的预测指标。使用log-rank检验和多变量分析评估显著预测因子。结果：虽然初始治疗前子宫内膜LBC的中性粒细胞计数和NLR评分是更有效的OR预测指标，但最准确的无进展状态预测指标是LEM/PEM前外周血NLR评分（0.722,95% CI: 0.45-0.99，敏感性：57.1%，特异性：94.4%）。结论：子宫内膜LBC中的炎症生物标志物无法预测LEN/PEM的疗效，而LEN/PEM之前采集的外周血NLR评分可能是一个重要的预测因子。

{"title":"A potential inflammatory biomarker for advanced endometrial cancer treated with lenvatinib plus pembrolizumab","authors":"Shintaro Yanazume, Yusuke Kobayashi, Yukari Kirita, Ikumi Kitazono, Chikako Nagata, Ayumi Kozai, Akihide Tanimoto, Hiroaki Kobayashi","doi":"10.1111/jog.16182","DOIUrl":"10.1111/jog.16182","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>To identify prognostic biomarkers that could predict how well patients will respond to lenvatinib/pembrolizumab (LEN/PEM). The utility of certain inflammatory biomarkers in endometrial liquid-based cytology (LBC) or peripheral blood samples, such as neutrophil counts, lymphocyte counts, and neutrophil-to-lymphocyte ratio (NLR) were explored.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study included 25 patients with advanced or recurrent endometrial cancer who had received LEN/PEM between August 2018 and March 2024. Predictors for overall response (OR), disease control, and progression-free survival, based on neutrophil/lymphocyte counts, NLR scores of the endometrial LBC prior to initial treatment, and peripheral blood prior to initial treatment and prior to LEM/PEM treatment were compared using a receiver operating characteristic curve. Significant predictors were evaluated using the log-rank test, and multivariate analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Although neutrophil counts and NLR score in endometrial LBC prior to initial treatment were better effective predictors for OR, the most accurate predictor of a progression-free status was NLR score in peripheral blood prior to LEM/PEM (0.722, 95% CI: 0.45–0.99, sensitivity: 57.1%, specificity: 94.4%). In peripheral blood prior to LEN/PEM, the lower NLR (NLR <5.39) group had a significantly longer PFS than the higher NLR (5.39 ≤ NLR) group (<i>p</i> = 0.023, median survival: 13.5 vs. 3.0 months), and tended to be independently correlated with PFS (hazard ratio = 2.571; 95% CI = 0.857–7.719; <i>p</i> = 0.092).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Inflammatory biomarkers in endometrial LBC failed to predict the efficacy of LEN/PEM, while peripheral blood NLR score sampled prior to LEN/PEM potentially could be a significant predictor.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11664300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between relaxin-2 levels in serum and mode of conception in twin gestations: A prospective cohort study 双胎妊娠血清松弛素-2水平与妊娠方式的关系：一项前瞻性队列研究。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-23 DOI: 10.1111/jog.16190

Angela Silvano, Oumaima Ammar, Astrid Parenti, Noemi Strambi, Viola Seravalli, Daniele Bani, Mariarosaria Di Tommaso

Aim

Relaxin is a peptide hormone commonly associated with pregnancy when it is thought to play a role in modulating various physiological processes to optimize maternal–fetal adaptation. In twin pregnancies these adaptive requirements are higher than in singleton pregnancies, therefore it is important to understand how circulating relaxin behaves in such conditions. This prospective cohort study aims to determine the serum relaxin-2 levels throughout gestation in twin pregnancies and to investigate its association with the mode of conception.

Methods

Blood samples were collected during each trimester of gestation from 26 women with twin pregnancies obtained through spontaneous conception (SC, n = 18) or assisted reproductive technologies, specifically through intracytoplasmic sperm injection (ART, n = 8). Serum relaxin-2 levels were measured by a highly sensitive ELISA method.

Results

The results indicated that serum relaxin-2 level peaks in the first trimester (491.05 ± 207.41 pg/mL), then decreases in the second trimester (446.27 ± 180.4 pg/mL; p < 0.057) and in the third trimester (422.19 ± 194.30 pg/mL; p < 0.025). Interestingly, the serum relaxin-2 level was higher in the spontaneous conception group with respect to the assisted reproductive technologies group (p < 0.001), when measured at each trimester of gestation. In addition, the multivariate regression analysis showed that only the assisted reproductive technologies had a significant impact on serum levels of relaxin-2 (p < 0.001), and no significant association was found with other women's clinical and demographic characteristics.

Conclusions

These findings extend the current knowledge about the pattern of circulating relaxin-2 throughout gestation in twin pregnancies, providing a sensitive measurement of serum relaxin-2 levels and a description of its putative physiological roles in humans.

目的：松弛素是一种肽激素，通常与妊娠有关，当它被认为在调节各种生理过程中发挥作用，以优化母胎适应。在双胎妊娠中，这些适应性要求比单胎妊娠更高，因此了解循环松弛素在这种情况下的行为是很重要的。本前瞻性队列研究旨在确定双胎妊娠期间血清松弛素-2水平，并探讨其与妊娠方式的关系。方法：对26例通过自然受孕（SC, n = 18）或辅助生殖技术，特别是通过胞浆内单精子注射（ART, n = 8）获得的双胎妊娠妇女，在妊娠的每个三个月采集血样。采用高灵敏度ELISA法检测血清松弛素-2水平。结果：血清松弛素-2水平在妊娠早期达到峰值（491.05±207.41 pg/mL），妊娠中期下降（446.27±180.4 pg/mL）；结论：这些发现扩展了目前关于双胎妊娠期间松弛素-2循环模式的知识，提供了一种血清松弛素-2水平的敏感测量方法，并描述了其在人类中可能的生理作用。

{"title":"Relationship between relaxin-2 levels in serum and mode of conception in twin gestations: A prospective cohort study","authors":"Angela Silvano, Oumaima Ammar, Astrid Parenti, Noemi Strambi, Viola Seravalli, Daniele Bani, Mariarosaria Di Tommaso","doi":"10.1111/jog.16190","DOIUrl":"10.1111/jog.16190","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Relaxin is a peptide hormone commonly associated with pregnancy when it is thought to play a role in modulating various physiological processes to optimize maternal–fetal adaptation. In twin pregnancies these adaptive requirements are higher than in singleton pregnancies, therefore it is important to understand how circulating relaxin behaves in such conditions. This prospective cohort study aims to determine the serum relaxin-2 levels throughout gestation in twin pregnancies and to investigate its association with the mode of conception.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Blood samples were collected during each trimester of gestation from 26 women with twin pregnancies obtained through spontaneous conception (SC, <i>n</i> = 18) or assisted reproductive technologies, specifically through intracytoplasmic sperm injection (ART, <i>n</i> = 8). Serum relaxin-2 levels were measured by a highly sensitive ELISA method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results indicated that serum relaxin-2 level peaks in the first trimester (491.05 ± 207.41 pg/mL), then decreases in the second trimester (446.27 ± 180.4 pg/mL; <i>p</i> < 0.057) and in the third trimester (422.19 ± 194.30 pg/mL; <i>p</i> < 0.025). Interestingly, the serum relaxin-2 level was higher in the spontaneous conception group with respect to the assisted reproductive technologies group (<i>p</i> < 0.001), when measured at each trimester of gestation. In addition, the multivariate regression analysis showed that only the assisted reproductive technologies had a significant impact on serum levels of relaxin-2 (<i>p</i> < 0.001), and no significant association was found with other women's clinical and demographic characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings extend the current knowledge about the pattern of circulating relaxin-2 throughout gestation in twin pregnancies, providing a sensitive measurement of serum relaxin-2 levels and a description of its putative physiological roles in humans.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142882143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are all vulvar masses Bartholin cysts? A series of cases 所有外阴肿块都是巴氏腺囊肿吗？一系列病例

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-16 DOI: 10.1111/jog.16186

Gizem Boz İzceyhan, Eralp Bulutlar

Introduction

While vulvar masses are not prevalent in society, they are one of the reasons for complaints that arise during visits to gynecology outpatient clinics. An excision is typically necessary for both the purpose of diagnosing and treating the condition.

Methods

We documented three exceptional instances with distinct histopathological diagnoses and varying presentations, as well as a consecutive series of five patients, including one Bartholin abscess and one labia major abscess.

Results

During the compilation of this article, we intended to show that vulvar masses can manifest in various forms. It is important not to overlook pathologies other than Bartholin cysts and abscesses, which are commonly encountered reasons for admission to gynecology clinics. Additionally, it is crucial to always consider the possibility of malignant pathologies.

Discussion

Clinicians' expertise and understanding of vulvar masses are comparatively inferior to their knowledge of other gynecological disorders. This case series presents the uncommon vulva masses that we found in our clinic.

导言：虽然外阴肿块在社会上并不普遍，但却是妇科门诊就诊时出现投诉的原因之一。为了诊断和治疗，通常需要进行切除手术：我们记录了三例组织病理学诊断不同、表现各异的特殊病例，以及五名患者的连续系列病例，包括一名巴氏脓肿患者和一名大阴唇脓肿患者：在撰写本文的过程中，我们希望说明外阴肿块的表现形式多种多样。除了巴氏腺囊肿和脓肿之外，我们还不能忽视其他病变，因为这些病变是妇科门诊常见的病因。此外，始终考虑恶性病变的可能性也至关重要：讨论：与其他妇科疾病相比，临床医生对外阴肿块的专业知识和了解相对较少。本系列病例介绍了我们在临床中发现的不常见的外阴肿块。

{"title":"Are all vulvar masses Bartholin cysts? A series of cases","authors":"Gizem Boz İzceyhan, Eralp Bulutlar","doi":"10.1111/jog.16186","DOIUrl":"10.1111/jog.16186","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>While vulvar masses are not prevalent in society, they are one of the reasons for complaints that arise during visits to gynecology outpatient clinics. An excision is typically necessary for both the purpose of diagnosing and treating the condition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We documented three exceptional instances with distinct histopathological diagnoses and varying presentations, as well as a consecutive series of five patients, including one Bartholin abscess and one labia major abscess.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the compilation of this article, we intended to show that vulvar masses can manifest in various forms. It is important not to overlook pathologies other than Bartholin cysts and abscesses, which are commonly encountered reasons for admission to gynecology clinics. Additionally, it is crucial to always consider the possibility of malignant pathologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Clinicians' expertise and understanding of vulvar masses are comparatively inferior to their knowledge of other gynecological disorders. This case series presents the uncommon vulva masses that we found in our clinic.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management strategy and experience of vasa previa in perinatal centers: A nationwide survey in Japan 围产中心处理前置胎盘的策略和经验：日本全国调查。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research

Pub Date : 2024-12-16 DOI: 10.1111/jog.16189

Manabu Ogoyama, Junichi Hasegawa, Shota Saji, Satsuki Hirono, Kenji Horie, Hirotada Suzuki, Hironori Takahashi

Aim

To clarify the current situation and outcomes of vasa previa (VP) in Japan.

Methods

A questionnaire survey on VP was conducted at all 408 perinatal centers in Japan. The content of the survey included (1) the management strategy for pregnant women who were diagnosed with VP and (2) the number and outcomes of VP cases managed between January 2020 and December 2022.

Results

Questionnaires were collected from 220 (53.9%: 220/408) perinatal centers. (1) A total of 78.8% (164/208) of facilities implemented routine hospitalization. Routine hospitalization was initiated at 32 (22–36) [median (range)] weeks of gestation. The timing of planned cesarean section (CS) was at 36 (33.5–39) weeks of gestation in 198 facilities. (2) Of the 220 facilities that responded, 109 (49.5%: 109/220) accommodated patients with VP during the observation period. The total number of VP cases was 351, with a frequency of one case (0–33) per single perinatal center for 3 years. Emergency CS was required in 89 cases (25.4%: 89/351). There were no fetal or neonatal deaths in this study. The number of undiagnosed patients with VP prenatally was seven (2.0%: 7/351). Umbilical vessel rupture occurred in two cases (0.6%: 2/351).

Conclusions

Current management strategies in Japanese perinatal centers that responded to this survey appear to yield good perinatal outcomes in VP. Additional studies and comparisons are needed to elucidate the necessity of routine hospitalization, the optimal duration of hospitalization, and the timing of planned CS.

目的：明确日本前置胎盘（VP）的现状和结果：在日本所有 408 家围产中心开展了一项关于前置胎盘的问卷调查。调查内容包括：（1）确诊为前置胎盘孕妇的处理策略；（2）2020 年 1 月至 2022 年 12 月期间处理的前置胎盘病例数量和结果：从 220 家（53.9%：220/408）围产中心收集了调查问卷。(1）共有 78.8%（164/208）的机构实施了常规住院治疗。常规住院治疗开始于妊娠 32（22-36）周[中位数（范围）]。在 198 家医疗机构中，计划剖宫产（CS）的时间为孕 36（33.5-39）周。(2）在做出回复的 220 家医疗机构中，有 109 家（49.5%：109/220）在观察期内收治了 VP 患者。VP 病例总数为 351 例，3 年中每个围产中心发生 1 例（0-33 例）。89例患者（25.4%：89/351）需要进行急诊手术。本研究中没有胎儿或新生儿死亡病例。产前未确诊的 VP 患者有 7 例（2.0%：7/351）。脐带血管破裂有两例（0.6%：2/351）：结论：参与此次调查的日本围产中心目前的管理策略似乎能为 VP 患者带来良好的围产期预后。需要进行更多的研究和比较，以阐明常规住院治疗的必要性、最佳住院时间以及计划 CS 的时机。

{"title":"Management strategy and experience of vasa previa in perinatal centers: A nationwide survey in Japan","authors":"Manabu Ogoyama, Junichi Hasegawa, Shota Saji, Satsuki Hirono, Kenji Horie, Hirotada Suzuki, Hironori Takahashi","doi":"10.1111/jog.16189","DOIUrl":"10.1111/jog.16189","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To clarify the current situation and outcomes of vasa previa (VP) in Japan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A questionnaire survey on VP was conducted at all 408 perinatal centers in Japan. The content of the survey included (1) the management strategy for pregnant women who were diagnosed with VP and (2) the number and outcomes of VP cases managed between January 2020 and December 2022.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Questionnaires were collected from 220 (53.9%: 220/408) perinatal centers. (1) A total of 78.8% (164/208) of facilities implemented routine hospitalization. Routine hospitalization was initiated at 32 (22–36) [median (range)] weeks of gestation. The timing of planned cesarean section (CS) was at 36 (33.5–39) weeks of gestation in 198 facilities. (2) Of the 220 facilities that responded, 109 (49.5%: 109/220) accommodated patients with VP during the observation period. The total number of VP cases was 351, with a frequency of one case (0–33) per single perinatal center for 3 years. Emergency CS was required in 89 cases (25.4%: 89/351). There were no fetal or neonatal deaths in this study. The number of undiagnosed patients with VP prenatally was seven (2.0%: 7/351). Umbilical vessel rupture occurred in two cases (0.6%: 2/351).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Current management strategies in Japanese perinatal centers that responded to this survey appear to yield good perinatal outcomes in VP. Additional studies and comparisons are needed to elucidate the necessity of routine hospitalization, the optimal duration of hospitalization, and the timing of planned CS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16593,"journal":{"name":"Journal of Obstetrics and Gynaecology Research","volume":"51 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0