Journal of oral rehabilitation最新文献_第7页

Dental Functional Status as a Possible Risk Factor of Sarcopenia: A Computed Tomography-Based Study 牙齿功能状态可能是 "肌肉疏松症 "的风险因素：基于计算机断层扫描的研究

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-11-08 DOI: 10.1111/joor.13896

Ceyda Gürhan, Funda Dinç

Background

Functional dentition may be associated with sarcopenia by affecting chewing activity.

Objectives

The objective of this study is to determine the sarcopenia status of participants using computed tomography (CT)-based data and to investigate the association of sarcopenia with functional dentition, as well as denture condition.

Methods

The study included 309 patients. The number of teeth was recorded. Functional dentition was evaluated based on the following parameters: (1) ≥ 1 tooth in the maxilla and mandible; (2) ≥ 10 teeth in each arch; (3) the presence of 12 anterior teeth; (4) 3–4 premolar posterior occlusal pairs (POPs) and (5) ≥ 1 molar POP bilaterally. The denture condition was also evaluated. CT-based assessment of sarcopenia was performed via measurement of the psoas muscle area at the level of the L3 vertebra and its hounsfield unit (HU) radiodensity on non-contrast-enhanced images. HU average calculation (HUAC), which is an imaging marker of sarcopenia, was performed. Gender-specific quartiles were then generated, and the lowest quartile of HUAC scores within each gender group was set as the cut-off point.

Results

A total of 76 (24.5%) of the patients had sarcopenia, and 233 (75.5%) did not have sarcopenia. The mean number of teeth in the sarcopenia group was 17.12 ± 8.39, compared to 22.24 ± 6.72 in those without sarcopenia (p < 0.001). The relationship between functional dentition and sarcopenia was also significant. There was a positive relationship between ill-fitting dentures and sarcopenia (p < 0.001).

Conclusions

This unique perspective of the study contributes to the existing knowledge regarding the role of tooth loss in sarcopenia, highlighting the importance of functional occlusion.

背景：功能性义齿可能会影响咀嚼活动，从而与肌肉疏松症有关：本研究的目的是利用基于计算机断层扫描（CT）的数据确定参与者的肌肉疏松症状况，并调查肌肉疏松症与功能性牙齿以及义齿状况的关联：研究包括 309 名患者。方法：研究纳入了 309 名患者，记录了他们的牙齿数量。功能性牙列根据以下参数进行评估：(1) 上颌和下颌≥1颗牙齿；(2) 每个牙弓≥10颗牙齿；(3) 有12颗前牙；(4) 有3-4对前磨牙后咬合面(POP)；(5) 双侧≥1颗磨牙后咬合面(POP)。此外，还对义齿状况进行了评估。肌肉疏松症的 CT 评估是通过测量 L3 椎体水平的腰肌面积及其在非对比度增强图像上的豪斯菲尔德单位（HU）放射密度进行的。HU平均值计算（HUAC）是肌肉疏松症的影像标记。然后生成按性别划分的四分位数，并将每个性别组中 HUAC 分数的最低四分位数设为分界点：共有 76 名患者（24.5%）患有肌肉疏松症，233 名患者（75.5%）未患有肌肉疏松症。肌肉疏松症组患者的平均牙齿数量为（17.12 ± 8.39）颗，而无肌肉疏松症组患者的平均牙齿数量为（22.24 ± 6.72）颗（P 结论：该研究的独特视角有助于了解肌肉疏松症组患者的牙齿数量：这项研究视角独特，有助于加深人们对牙齿缺失在肌肉疏松症中作用的认识，突出了功能性咬合的重要性。

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引用次数: 0

Conditioned Pain Modulation Differences in Central and Peripheral Burning Mouth Syndrome (BMS) Patients. 中枢性和外周性烧灼口腔综合征（BMS）患者的条件性疼痛调节差异。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-11-04 DOI: 10.1111/joor.13876

Guangju Yang, Jianqiu Jin, Kelun Wang, Lene Baad-Hansen, Hongwei Liu, Ye Cao, Qiu-Fei Xie, Peter Svensson

Aim: To evaluate conditioned pain modulation (CPM) in burning mouth syndrome (BMS) patients with different pain mechanisms.

Materials and methods: Twenty BMS patients (52.0 ± 6.8 years, 17 women and 3 men) and age- and gender-matched 22 healthy controls were enrolled in this randomised controlled trial. The patients received an active lingual nerve block (lidocaine) and a placebo injection (saline) randomly with an interval of 1 week in a double-blinded manner. Patients evaluated their pain intensity on a 0- to 10-cm visual analogue scale (VAS) before and after each injection, with or without CPM. Based on the anaesthesia effect, BMS patients were divided into two groups with presumed different pain mechanisms; a 'central subgroup (n = 11)' with pain relief less than 1 cm and 'peripheral subgroup (n = 9)' with pain relief more than 1 cm on the VAS. Mechanical pain threshold (MPT) and wind-up ratio (WUR) were investigated at two oral mucosa regions: the region with most intense symptoms and a control region for the patient group; tongue and buccal region for the control group. CPM was induced by immersing the left hand into cold water. A moderate level of pain (around five on the VAS) was obtained by adjusting the water temperature. MPT and WUR were measured twice for all the participants with and without CPM, which was analysed and presented as relative change in MPT and WUR. Differences between groups were analysed using two-way ANOVA. Differences within group between tests were assessed by paired t-test.

Results: At baseline, there were no significant group differences for MPT or WUR between BMS patients and healthy controls (p ≥ 0.156). The mean bath temperature to evoke moderate pain for the BMS group was significantly lower than that for the healthy control group (8.9°C vs. 11.9°C, p = 0.003). The CPM evoked an inhibitory modulation in 18.2%-44.4% of BMS patients, while for the healthy group, the ratio was 68.2%-81.8%. Central BMS patients had smaller CPM effects than healthy participants at the painful site and control site, which indicated a decreased CPM function (p ≤ 0.034). Peripheral BMS patients had lower CPM effects than healthy participants only at the painful site (p = 0.037).

Conclusions: The present findings documented impairment of central nociceptive inhibition processing in BMS patients which was more extensive in central BMS than peripheral BMS. These findings add to the suggestion that BMS may a heterogeneous pain condition with at least two different phenotypes.

目的：评估不同疼痛机制的烧灼口腔综合征（BMS）患者的条件性疼痛调节（CPM）：这项随机对照试验招募了 20 名灼热口腔综合征患者（52.0 ± 6.8 岁，17 名女性和 3 名男性）以及年龄和性别匹配的 22 名健康对照者。患者在双盲的情况下随机接受活性舌神经阻滞注射（利多卡因）和安慰剂注射（生理盐水），间隔时间为一周。每次注射前后，患者都会用 0 至 10 厘米的视觉模拟量表（VAS）评估自己的疼痛强度，无论是否使用 CPM。根据麻醉效果，BMS 患者被分为推测疼痛机制不同的两组：疼痛缓解小于 1 厘米的 "中心亚组（n = 11）"和疼痛缓解大于 VAS 1 厘米的 "外周亚组（n = 9）"。在两个口腔粘膜区域调查了机械痛阈值（MPT）和上卷率（WUR）：患者组为症状最强烈的区域和对照组区域；对照组为舌头和颊部区域。将左手浸入冷水中可诱发 CPM。通过调节水温可获得中等程度的疼痛（VAS 值约为 5）。对有和没有 CPM 的所有参与者的 MPT 和 WUR 进行了两次测量，并以 MPT 和 WUR 的相对变化进行分析和呈现。组间差异采用双向方差分析。组内不同测试之间的差异采用配对 t 检验：基线时，BMS 患者和健康对照组之间的 MPT 或 WUR 没有明显的组间差异（p ≥ 0.156）。BMS 组唤起中度疼痛的平均浴温明显低于健康对照组（8.9°C vs. 11.9°C，p = 0.003）。18.2%-44.4%的 BMS 患者的 CPM 会诱发抑制性调节，而健康对照组的这一比例为 68.2%-81.8%。中枢性 BMS 患者在疼痛部位和对照部位的 CPM 作用小于健康参与者，这表明 CPM 功能下降（p ≤ 0.034）。外周 BMS 患者仅在疼痛部位的 CPM 效应低于健康参与者（p = 0.037）：本研究结果表明，BMS 患者的中枢痛觉抑制处理功能受损，且中枢 BMS 比外周 BMS 的受损范围更广。这些发现进一步表明，BMS 可能是一种异质性疼痛，至少有两种不同的表型。

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引用次数: 0

Effect of Lingual Nerve Block and Localised Somatosensory Abnormalities in Patients With Burning Mouth Syndrome-A Randomised Crossover Double-Blind Trial. 灼口综合征患者舌神经阻滞和局部躯体感觉异常的影响--随机交叉双盲实验

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-11-04 DOI: 10.1111/joor.13877

Guangju Yang, Jianqiu Jin, Kelun Wang, Lene Baad-Hansen, Hongwei Liu, Ye Cao, Qiu-Fei Xie, Peter Svensson

Aims: To investigate the effect of a lingual nerve block on spontaneous pain in patients with burning mouth syndrome (BMS) and to estimate associated somatosensory abnormalities by quantitative sensory testing (QST).

Protocol and methods: A standardised QST battery including cold detection threshold (CDT), warmth detection threshold (WDT), thermal sensory limen (TSL), paradoxical heat sensation (PHS), cold pain threshold (CPT), heat pain threshold (HPT), mechanical pain threshold (MPT), wind-up ratio (WUR) and pressure pain threshold (PPT) was performed at the oral mucosa of the most painful site and intraoral control site in 20 BMS patients, and at the tongue and cheek mucosa in 22 age- and gender-matched healthy controls. The effect of a lingual nerve block on spontaneous burning pain reported by the BMS patients on a 0-10 cm visual analogue scale (VAS) was investigated in a randomised double-blind crossover design using (1 mL) lidocaine (lido) or saline (sal) with an interval of 1 week. The BMS patients were grouped into 'central' and 'peripheral' mechanisms based on the effect of the lingual nerve injections. For each BMS patient, Z-scores and Loss/Gain scores were computed. Differences among groups and sites were analysed using a two-way ANOVA. Differences within group were assessed by paired t-test.

Results: The 20 BMS patients were characterised on the basis of VAS changes (ΔLido-ΔSal) as a peripheral BMS subgroup (n = 9) with pain relief more than 1 cm on the VAS and a central BMS subgroup (n = 11) with pain relief less than 1 cm. BMS patients (n = 20) had lower sensitivity to thermal stimuli (i.e., CDT, WDT, TSL, CPT, HPT and PPT) and higher sensitivity to mechanical stimuli (i.e., PPT) compared with controls (p ≤ 0.007). Based on Loss/Gain coding, L1G0 (loss of thermal somatosensory function with no somatosensory gain, 55.0%) was the most frequent coding in the BMS group, which was higher than 11.4% in the control group (p < 0.001). Surprisingly, there was no significant difference between the peripheral and central BMS subgroups with regard to the Z-scores of any of the nine QST parameters (p > 0.097).

Conclusions: The results of the lingual nerve blocks demonstrated two distinct phenotypes with either peripheral or central mechanisms but no direct impact on somatosensory function. Overall, somatosensory function in BMS patients seems abnormal in the painful areas compared to matched controls with a conspicuous loss of thermosensory function.

目的：研究舌神经阻滞对烧灼口腔综合征（BMS）患者自发疼痛的影响，并通过定量感觉测试（QST）估计相关的体感异常：标准化 QST 电池包括冷检测阈值 (CDT)、热检测阈值 (WDT)、热感觉临界值 (TSL)、矛盾热感觉 (PHS)、冷痛阈值 (CPT)、热痛阈值 (HPT)、机械痛阈值 (MPT)、在 20 名 BMS 患者最疼痛部位的口腔粘膜和口腔内对照部位，以及 22 名年龄和性别匹配的健康对照者的舌和颊粘膜上，分别进行了上风比（WUR）和压力痛阈值（PPT）测试。采用随机双盲交叉设计，使用（1 毫升）利多卡因（lido）或生理盐水（sal），间隔 1 周，研究了舌神经阻滞对 BMS 患者在 0-10 厘米视觉模拟量表（VAS）上自发灼痛的影响。根据舌神经注射的效果，将 BMS 患者分为 "中枢 "和 "外周 "两组。计算每位 BMS 患者的 Z 值和损失/增益得分。采用双向方差分析法分析各组和各部位之间的差异。组内差异采用配对 t 检验：根据 VAS 变化（ΔLido-ΔSal）将 20 名 BMS 患者分为外周 BMS 亚组（n = 9）和中心 BMS 亚组（n = 11），前者的 VAS 疼痛缓解超过 1 厘米，后者的 VAS 疼痛缓解小于 1 厘米。与对照组相比，BMS 患者（n = 20）对热刺激（即 CDT、WDT、TSL、CPT、HPT 和 PPT）的敏感度较低，而对机械刺激（即 PPT）的敏感度较高（p ≤ 0.007）。根据丧失/增益编码，L1G0（热躯体感觉功能丧失，无躯体感觉增益，55.0%）是 BMS 组最常见的编码，高于对照组的 11.4%（P 0.097）：舌神经阻滞的结果显示了两种不同的表型，其机制或为外周机制，或为中枢机制，但对躯体感觉功能没有直接影响。总体而言，与匹配的对照组相比，BMS 患者疼痛部位的躯体感觉功能似乎异常，热感觉功能明显丧失。

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引用次数: 0

Trial Waste in Hyaluronic Acid-Related Randomised Controlled Trials 透明质酸相关随机对照试验中的试验废弃物。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-11-01 DOI: 10.1111/joor.13889

Hongrui Chen, Qinqi Yu, Zening Huang, Bin Sun, Chen Hua, Xiaoxi Lin

Background

A notable obstacle in applying the findings of hyaluronic acid (HA)-related randomised controlled trials (RCTs) to real-world patient treatment is trial waste (TW). To date, the extent of TW in RCTs for HA is not clear.

Objectives

To analyse the extents of TW within HA-RCTs and identify protective factors against TW.

Methods

In July 2024, we searched the ClinicalTrials database using the ‘hyaluronic acid’ as keyword. We documented the data available and then explored PubMed and Scopus for the publication status. Reporting adequacy was evaluated using the CONSORT checklist. Design limitations were analysed based on bias risk and whether the article referenced a relevant systematic review. Subsequently, we evaluated extent of TW (unpublished studies, insufficient reporting and design flaws).

Results

One hundred and eighty-four RCTs met the inclusion criteria. The analysis of TW excluded 53 RCTs completed after June 2020 that remained unpublished. Among the remaining 131 RCTs, 72 were published, 47 had adequate reporting and 19 had design limitations. Taken together, 96 RCTs (73.3%) exhibited at least one characteristic of TW. Characteristics of these RCTs included early registration (p < 0.001) and the absence of a multi-blind approach (p = 0.007). Registration prior to 2014 (p < 0.001) and the open-label or single-blinding design (p = 0.003) emerged as independent risk factor for TW.

Conclusion

We delineated the features of 184 HA-related RCTs. 73.3% of the RCTs included in TW analysis exhibited TW. The diverse traits of the different TW indicators identified could serve as valuable insights for conducting future HA-RCTs more rationally and efficiently.

背景：将与透明质酸（HA）相关的随机对照试验（RCT）结果应用于实际患者治疗的一个显著障碍是试验废物（TW）。迄今为止，透明质酸随机对照试验中的试验废物程度尚不清楚：分析医管局随机对照试验中 TW 的程度，并确定防止 TW 的保护因素：2024 年 7 月，我们以 "透明质酸 "为关键词搜索了临床试验数据库。我们记录了可用数据，然后浏览了 PubMed 和 Scopus，以了解发表情况。我们使用 CONSORT 核对表评估了报告的充分性。根据偏倚风险以及文章是否引用了相关的系统综述，对设计局限性进行了分析。随后，我们评估了 TW 的范围（未发表的研究、报告不充分和设计缺陷）：结果：184 项 RCT 符合纳入标准。对 TW 的分析排除了在 2020 年 6 月之后完成但仍未发表的 53 项 RCT。在剩余的 131 项研究中，72 项已发表，47 项报告充分，19 项存在设计缺陷。总之，96 项研究性试验（73.3%）至少表现出 TW 的一个特征。这些研究性试验的特点包括早期注册（P 结论）：我们描述了 184 项 HA 相关 RCT 的特征。在纳入 TW 分析的 RCT 中，73.3% 表现出 TW 特征。所发现的不同 TW 指标的不同特征可作为宝贵的启示，有助于今后更合理、更有效地开展医管局的 RCT 研究。

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引用次数: 0

Treatment Outcomes of Four-Implant-Retained Maxillary Palateless Overdenture: A 5-Year Observational Study 四种植体固位的上颌无托槽覆盖义齿的治疗效果：一项为期 5 年的观察研究

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-11-01 DOI: 10.1111/joor.13887

Asha Sude, Kimberly K. Schlam, Hector Saenz de Viteri Tejeda, Glenn J. Reside, Anne E. Sanders, David A. Felton, Ingeborg J. De Kok

Introduction

Palateless overdentures (PLODs) provide advantages of improved taste perception and retention over conventional dentures. We aimed to evaluate 5-year outcomes of four implant maxillary PLODs.

Methods

In this prospective observational study, edentulous participants were enrolled. A new conventional maxillary denture was prepared followed by implant placement and insertion of four implant retained maxillary PLOD. Oral health quality of life was assessed using the 49-item Oral Health Impact Profile (OHIP-49) at multiple intervals over 5 years along with biological and mechanical outcomes.

Results

Nine patients were evaluated at year 5. The mean age was 68 years, and six of the nine patients were males. The cumulative survival rate of implants was 100% while the implant success rate was 86%. Nylon retentive replacement was the most common encountered complication noted approximately four times per patient over 5 years. From a mean OHIP-49 severity score of 71.2 at baseline, severity scores decreased to 23.9 (p < 0.001) at year 1, denoting a clinically meaningful and statistically significant improvement in oral health quality of life. The lowered OHIP-49 severity scores remained stable throughout 5 years of follow-up.

Conclusion

Four implant supported maxillary overdenture appears to have good patient perceived, biological and mechanical outcomes over 5 years. Fully powered studies are needed to replicate these findings.

简介与传统假牙相比，无腭覆盖义齿（PLOD）具有改善味觉和固位的优点。我们的目的是评估四种种植体上颌无腭覆盖义齿的五年疗效：在这项前瞻性观察研究中，我们招募了无牙患者。在准备好一个新的传统上颌义齿后，植入种植体并安装四个种植体固位的上颌PLOD。使用 49 项口腔健康影响档案（OHIP-49）对口腔健康生活质量进行评估，评估间隔时间为 5 年，同时评估生物学和机械学结果：第 5 年对 9 名患者进行了评估。平均年龄为 68 岁，9 名患者中有 6 名男性。种植体的累积存活率为 100%，种植成功率为 86%。尼龙固位替换是最常见的并发症，5 年中每位患者约发生 4 次。基线时，OHIP-49 的平均严重程度为 71.2 分，而现在严重程度已降至 23.9 分（P，结论）：4颗种植体支持的上颌覆盖义齿在5年内似乎具有良好的患者感知、生物和机械效果。需要进行充分的研究来验证这些发现。

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引用次数: 0

Weight Loss and Number of Present Teeth in Community-Dwelling Japanese Older Adults: A Cross-Sectional Study in Niigata 居住在社区的日本老年人的体重减轻与现齿数量：新潟县的一项横断面研究。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-11-01 DOI: 10.1111/joor.13886

Sachiko Takehara, Masayuki Ueno, Akihiro Yoshihara, Masanori Iwasaki, Kana Suwama, Kumiko Minagawa, Ichiei Narita, Junta Tanaka, Hiroshi Ogawa, Yumi Ito

Background and Objectives

Weight loss is a critical health issue among the older population. This study aimed to explore the association between weight loss and oral health in older adults.

Methods

We used cross-sectional data from the Uonuma Chronic Kidney Disease Cohort Study. The binary logistic regression models were fitted to estimate the relationship between weight loss and independent variables including the number of teeth present.

Results

The participants included 1656 females and 1625 males. There were 1217 females (73.4%) and 1236 males (76.0%) with normal BMI (18.5 ≤ BMI < 25) in the previous year. Weight loss was determined over a 12-month period. Individuals with normal BMI in previous year, and those with weight loss (≥ 5%) or those whom maintained a stable weight were further analysed. The regression analysis (model 3, fully adjusted) showed that females with 0 and 1–10 teeth present had a higher likelihood of losing weight (OR = 4.07; 95% CI = 1.85–8.93, OR = 2.33; 95% CI = 1.24–4.39) compared with those with 20 or more teeth. Current smokers had a higher likelihood of losing weight (OR = 3.15; 95% CI = 1.01–9.76) than lifelong abstainers. Among males, both current and previous smokers showed a higher likelihood of losing weight (OR = 4.94; 95%CI = 1.76–13.8, OR = 3.35; 95% CI = 1.29–8.68) than those who never smoked.

Conclusions

This study indicates that the number of teeth and smoking are both linked to weight loss in females. However, in males, the association between the number of teeth and weight loss may be compromised due to the high prevalence of smoking in this group.

背景和目的：减肥是老年人口中的一个重要健康问题。本研究旨在探讨老年人体重减轻与口腔健康之间的关系：我们使用了来自 Uonuma 慢性肾病队列研究的横断面数据。方法：我们利用鱼沼慢性肾脏病队列研究的横断面数据，通过二元逻辑回归模型来估计体重减轻与包括牙齿数量在内的自变量之间的关系：参与者包括 1656 名女性和 1625 名男性。其中有 1217 名女性（73.4%）和 1236 名男性（76.0%）体重指数正常（18.5≤体重指数）：这项研究表明，女性的牙齿数量和吸烟都与体重减轻有关。然而，在男性中，由于吸烟率较高，牙齿数量与体重减轻之间的关系可能会受到影响。

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引用次数: 0

Cross Cultural Validation of Oral Health Index Profile for Temporomandibular Disorders in Spanish Speaking Population 西班牙语人群颞下颌关节紊乱口腔健康指数档案的跨文化验证。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-10-31 DOI: 10.1111/joor.13881

Juan Fernando Oyarzo, Carolina Manriquez, Justin Durham

Objectives

Structured patient-centred assessment is critical for improving care. OHIP-TMDs are a validated English-language outcome measure for temporomandibular disorders (TMD) which evaluates the biopsychosocial impact of TMD. Due to language and cultural changes, the original instrument's phrasing of its items may change when translated to Spanish. This study cross-culturally adapted and validated OHIP-TMDs for Spanish-speaking individuals with TMD.

Methods

OHIP-TMDs was forward-backward translated into Spanish (OHIP-TMDs-Sp) and cross-culturally adapted to a Hispanic population with TMD (Diagnostic Criteria for TMD n = 154) according to international norms. All patients completed the OHIP-TMDs-Sp, the Graded Chronic Pain Scale (GCPS), and Jaw Functional Limitation Scale (JFLS-20). A subsample (n = 30) recompleted the OHIP-TMDs-Sp after a 3-week washout to measure test–retest reliability using an intra-class correlation coefficient (ICC 2.1). OHIP-TMDs-Sp, JFLS-20, and GCPS were analysed for convergent validity and internal consistency.

Results

The sample with articular and muscular TMD diagnoses was 85.7% female with a mean age of 29.5. (SD 9.01). OHIP-TMDs-Sp had high internal reliability (Cronbach's Alpha = 0.95) and good test–retest reliability (ICC = 0.82; 95% CI = 0.57–0.93). In terms of convergent validity, the OHIP-TMDs-Sp demonstrated moderate to large positive correlations with the total JLFS-20 score (ρ = 0.72; p < 0.01), Mastication (ρ = 0.68; p < 0.01), Communication (ρ = 0.68; p < 0.001), as well to GCPS disability score (ρ = 0.59; p < 0.01), and characteristic pain intensity (ρ = 0.69; p < 0.01).

Conclusions

The total score of OHIP-TMDs-Sp is reliable for assessing quality-of-life in Spanish-speaking TMD patients.

目的：以患者为中心的结构化评估对于改善护理至关重要。OHIP-TMDs是一种经过验证的颞下颌关节紊乱症（TMD）英文结果测量工具，用于评估TMD的生物心理社会影响。由于语言和文化的变化，在翻译成西班牙语时，原始工具的项目措辞可能会发生变化。本研究针对讲西班牙语的 TMD 患者对 OHIP-TMDs 进行了跨文化改编和验证：将 OHIP-TMDs 前向后翻译成西班牙语（OHIP-TMDs-Sp），并根据国际规范对西班牙语 TMD 患者（TMD 诊断标准 n = 154）进行跨文化改编。所有患者均完成了 OHIP-TMDs-Sp、慢性疼痛分级量表 (GCPS) 和下颌功能限制量表 (JFLS-20)。一个子样本（n = 30）在 3 周冲洗后重新填写了 OHIP-TMDs-Sp，以使用类内相关系数（ICC 2.1）测量测试-重测可靠性。对 OHIP-TMDs-Sp、JFLS-20 和 GCPS 进行了收敛有效性和内部一致性分析：被诊断为关节型和肌肉型 TMD 的样本中，85.7% 为女性，平均年龄为 29.5 岁。(SD 9.01)。OHIP-TMDs-Sp具有较高的内部可靠性（Cronbach's Alpha = 0.95）和良好的测试-再测可靠性（ICC = 0.82; 95% CI = 0.57-0.93）。OHIP-TMDs-Sp 的总分对于评估西班牙语 TMD 患者的生活质量是可靠的。

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引用次数: 0

Ontology and Bruxism: Do We Have Enough Information? 本体论与布鲁克斯主义：我们有足够的信息吗？

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-10-31 DOI: 10.1111/joor.13890

Daniele Manfredini, Frank Lobbezoo

The idea of classifying and defining bruxism according to ontological principles may be interesting, but currently we just do not have enough information to label in a black or white manner the many facets of bruxism. In an era in which general knowledge on bruxism by the dental communities is surely in need of improvement, efforts to clarify the road map tracked by the current panelists who drafted the definition should be appraised carefully. The recent introduction of a standardized multidimensional evaluation system (i.e., Standardized Tool for the Assessment of Bruxism [STAB]) and a screening instrument for bruxism (i.e., BruxScreen) should be viewed as the starting points to enter a new era in the discipline of bruxism, in which non-hierarchical and non-preconceived approaches are used to collect data. Artificial intelligence strategies to mine data gathered with the above instruments might help building predictive models along the etiology-status-consequences trajectory, as recently suggested in a model for awake bruxism metrics. Until then, proposals to adopt ontological principles to classify bruxism will be merely based on speculations rather than on facts.

根据本体论原则对磨牙症进行分类和定义的想法可能很有趣，但目前我们还没有足够的信息来对磨牙症的许多方面进行非黑即白的标注。在牙科界对磨牙症的普遍认识亟待提高的今天，我们应该认真评估目前起草定义的专家小组所制定的路线图。最近推出的标准化多维评估系统（即磨牙症评估标准化工具[STAB]）和磨牙症筛查工具（即BruxScreen）应被视为磨牙症学科进入新纪元的起点，在新纪元中，将使用非等级和非先入为主的方法来收集数据。利用人工智能策略挖掘上述工具收集的数据，可能有助于沿着病因-状态-后果的轨迹建立预测模型，正如最近在唤醒磨牙症指标模型中提出的那样。在此之前，采用本体论原则对磨牙症进行分类的建议将仅仅基于推测而非事实。

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引用次数: 0

Genome-Wide Association Study of Temporomandibular Disorder-Related Pain in Finnish Populations 芬兰人群中与颞下颌关节紊乱有关的疼痛的全基因组关联研究》（Genome-Wide Association Study of Temporomandibular Disorder-Related Pain in Finnish Populations）。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-10-31 DOI: 10.1111/joor.13883

J. M. Leppilahti, J. Knuutila, P. Pesonen, V. Vuollo, M. Männikkö, M. K. Karjalainen, A. L. Suominen, K. Sipilä

Background

Temporomandibular disorders (TMD) are multifactorial musculoskeletal pain and dysfunctions in temporomandibular joints (TMJs) and masticatory muscles. Genetic factors play a role in TMD-related pain, but only a few genome-wide association studies (GWAS) have been conducted.

Objective

The aim of this GWAS was to explore genetic factors associated with painful TMD in Finnish populations.

Methods

Data from two epidemiological surveys, the Northern Finland Birth Cohort 1966 (NFBC1966) and the Health 2000 Survey in Finland, including altogether 468 cases and 6833 controls, were used. Case definition was based on pain on palpation of masticatory muscles and/or TMJs. GWASs of the whole data and stratified by sex were conducted from both cohorts using additive models, followed by meta-analysis of the two cohorts. Replications of the previously reported TMD risk loci (rs73460075, DMD; rs4794106, SGCA; rs73271865, SP4; rs60249166, RXP2; rs1531554, BAHCCI; rs5862730, OTUD4/SMAD1; rs10092633, SFRP1; rs34612513, SOX14/CLDN18; rs878962, TSPAN9) were also investigated.

Results

Four genome-wide significant loci were found in sex-stratified analysis of NFBC1966, including associations at three loci in males (rs1023114, PRIM2, p = 5 × 10⁻⁹; rs4244867, ALG10, p = 3 × 10⁻⁸; rs79841648, ADCYAP1, p = 4 × 10⁻⁹) and one locus in females (rs148476652, DNER, p = 4 × 10⁻⁹). However, the results could not be replicated in the Health 2000 Survey or in the meta-analysis of these two cohorts. The previous TMD GWAS associations did not replicate in our data either.

Conclusion

Several TMD pain-associated variants were found in sex-stratified analysis of NFBC1966, suggesting the role of neuroendocrine stress responses and central nervous system. These findings need to be confirmed in future studies.

背景：颞下颌关节紊乱（TMD）是由多种因素引起的肌肉骨骼疼痛以及颞下颌关节（TMJ）和咀嚼肌的功能障碍。遗传因素在 TMD 相关疼痛中起着一定的作用，但目前仅开展了几项全基因组关联研究（GWAS）：这项全基因组关联研究旨在探索芬兰人群中与 TMD 疼痛相关的遗传因素：方法：研究人员使用了1966年北芬兰出生队列（NFBC1966）和2000年芬兰健康调查（Health 2000 Survey in Finland）这两项流行病学调查的数据，其中包括468例病例和6833例对照。病例定义以咀嚼肌和/或颞下颌关节触诊疼痛为依据。利用加法模型对两个队列的全部数据和按性别分层的数据进行了基因组学分析，然后对两个队列进行了荟萃分析。此外，还对之前报道的 TMD 风险位点（rs73460075，DMD；rs4794106，SGCA；rs73271865，SP4；rs60249166，RXP2；rs1531554，BAHCCI；rs5862730，OTUD4/SMAD1；rs10092633，SFRP1；rs34612513，SOX14/CLDN18；rs878962，TSPAN9）的重复位点进行了研究：结果：在对NFBC1966的性别分层分析中发现了四个全基因组显著位点，包括男性的三个位点（rs1023114，PRIM2，p = 5 × 10-9；rs4244867，ALG10，p = 3 × 10-8；rs79841648，ADCYAP1，p = 4 × 10-9）和女性的一个位点（rs148476652，DNER，p = 4 × 10-9）。然而，这些结果无法在 2000 年健康调查或这两个队列的荟萃分析中得到重复。我们的数据也没有重复之前的 TMD GWAS 关联：结论：在 NFBC1966 的性别分层分析中发现了几个与 TMD 疼痛相关的变异，这表明神经内分泌应激反应和中枢神经系统发挥了作用。这些发现需要在今后的研究中加以证实。

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引用次数: 0

Let's Start Using the BruxScreen to Perform the Still-Needed Psychometric Tests 让我们开始使用 BruxScreen 进行仍然需要的心理测试。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-10-31 DOI: 10.1111/joor.13888

Frank Lobbezoo, Jari Ahlberg, Laura Nykänen, Daniele Manfredini, Merel C. Verhoeff

<p>With great interest, we have read the Commentary ‘Letter to the editor regarding the bruxism screener questionnaire (BruxScreen)’ by Grossi & Filho [<span>1</span>]. The authors comment on the 5-point verbal scale that we proposed to score the self-report items in the first part of the BruxScreen, the BruxScreen-Q [<span>2</span>]. More specifically, their concerns are related to the first question with six bruxism items, and most specifically to the items that deal with sleep bruxism (SB). According to Grossi & Filho, the response options of these items (i.e., never, sometimes, regularly, often, always and don't know) may give rise to misinterpretation [<span>1</span>]. They state that response options that identify a specific time relation (e.g., the number of bruxism occurrences per week or month) should be used instead. They argue that such an approach would better match the criteria that have been used by Lavigne et al. [<span>3</span>] and Rompré et al. [<span>4</span>] to select the patients for their studies establishing polysomnographically (PSG-)based cut-off criteria for SB diagnosis.</p><p>Although their reasoning is clear, some issues need to be pointed out. First, Lavigne et al. [<span>3</span>] and Rompré et al. [<span>4</span>] did not intend to develop true diagnostic cut-off criteria, and certainly not a ‘one size fits all’ application of their criteria to be used for all patients with SB, regardless of their specific phenotypes. Rather, Lavigne et al. [<span>3</span>] proposed their finding to be used for research purposes, whereas Rompré et al. [<span>4</span>] looked for a distinction between SB subgroups with different risks of pain. In line with this, Manfredini et al. discussed the need to abandon the use of cut-off criteria for establishing the presence or absence of bruxism [<span>5</span>]. Instead, they suggested to consider all relevant measures and values for the characterisation of the various types of bruxism. An important reason for this is that it is impossible to pinpoint which amount and type of bruxism are associated with which potential negative (e.g., temporomandibular disorders, mechanical tooth wear and failure of dental restorations) or positive (e.g., opening a collapsed upper airway in patients with obstructive sleep apnoea and exerting a positive effect on cognitive function) health outcome, if any [<span>6</span>]. In case of multiple health outcomes, the situation is even more complex. Thus, using cut-off values as a ‘one size fits all’ approach to establishing the presence or absence of bruxism is no longer appropriate.</p><p>Second, the reasoning by Grossi & Filho [<span>1</span>], that scoring bruxism on a scale that consists of response options with a specific time relation fits better with the work of Lavigne et al. [<span>3</span>] and Rompré et al. [<span>4</span>], suffers from circular reasoning. The PSG-based cut-off criteria of Lavigne et al. [<span>3</span>] and Rompré et a

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引用次数: 0