Journal of oral rehabilitation最新文献_第7页

Is There an Increase in Possible Sleep Bruxism in Children Over Time? A Longitudinal Study 儿童可能出现的睡眠磨牙症是否会随着时间的推移而增加？一项纵向研究。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-09-03 DOI: 10.1111/joor.13851

Josiane Pezzini Soares, Júnia Maria Serra-Negra, Juliana da Silva Moro, Pablo Silveira Santos, Giana Brancher, Maria Eduarda Evangelista, Mariane Cardoso, Carla Miranda Santana, Michele Bolan

Background

Bruxism is a behaviour that has several consequences in an individual's life, especially when it starts in childhood. However, bruxism can be a potential protective factor, which is an attribute that reduces the chance of a negative health outcome.

Objectives

To evaluate the incidence of sleep bruxism (SB) and dental wear in children and adolescents.

Materials and Methods

This longitudinal study began in 2014 and 2016 (baseline) with initial 1816 children followed for 5 and 3 years, respectively. The follow-up data collection started in 2019. The diagnosis of SB was parents report (baseline) and self-report (follow-up) due to age groups of each phase, and questions related to symptoms of SB were collected. Five calibrated examiners (kappa >0.7) collected the clinical data. The clinical variables were dental erosion and dental wear. Contextual, individual, behaviour and clinical characteristics were collected. A multilevel logistic regression model was used to investigate the association of contextual, individual, behaviour and clinical characteristics with SB. Poisson regression for repeated measures was performed to evaluate the incidence of SB and dental wear (incidence rate ratio—IRR and confidence interval—95% CI).

Results

Two hundred and fifty-three children and adolescents answered questionnaires and were clinically examined. The mean age of the follow-up in 2019 was 11.25 years old (±2.19). There was no increase in the incidence of SB (95% CI: 0.74–1.35). Children/adolescents had a 2.2 higher risk to present dental wear (95% CI: 1.89–2.60). SB at the follow-up was associated with the contextual variable, earache, erosion and awake bruxism.

Conclusions

In this population, children with SB remained with this behaviour and showed higher dental wear over the years.

背景介绍磨牙是一种会对个人生活造成多种影响的行为，尤其是在儿童时期。然而，磨牙也可能是一种潜在的保护性因素，它是一种可降低不良健康后果发生几率的属性：评估儿童和青少年睡眠磨牙症（SB）和牙齿磨损的发生率：这项纵向研究始于 2014 年和 2016 年（基线），最初分别对 1816 名儿童进行了为期 5 年和 3 年的随访。随访数据收集始于 2019 年。由于每个阶段的年龄组不同，SB 的诊断分别由家长报告（基线）和自我报告（随访），并收集了与 SB 症状相关的问题。五名经过校准的检查员（kappa>0.7）收集了临床数据。临床变量为牙齿腐蚀和牙齿磨损。还收集了环境、个人、行为和临床特征。采用多层次逻辑回归模型来研究环境、个人、行为和临床特征与 SB 的关系。对重复测量进行泊松回归，以评估 SB 和牙齿磨损的发生率（发生率比-IRR 和置信区间-95% CI）：253名儿童和青少年回答了问卷并接受了临床检查。2019 年随访的平均年龄为 11.25 岁（±2.19）。SB发病率没有增加（95% CI：0.74-1.35）。儿童/青少年出现牙齿磨损的风险高出2.2（95% CI：1.89-2.60）。随访中的SB与环境变量、耳痛、牙蚀和清醒磨牙症有关：结论：在这一人群中，患有磨牙症的儿童多年来一直存在这种行为，并表现出较高的牙齿磨损程度。

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引用次数: 0

Effects of gum chewing training on occlusal force, masseter muscle thickness and mandibular shape: A randomised controlled clinical trial 咀嚼口香糖训练对咬合力、颌下肌厚度和下颌骨形态的影响：随机对照临床试验

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-30 DOI: 10.1111/joor.13830

Hyo-Jung Jung, Na Kyung Hwangbo, Younjung Park, Hyung-Joon Ahn

Background

Masticatory muscle training by chewing gum can be performed easily and improve masticatory muscle function and strength. However, increased masticatory muscle activity and function may alter the mandibular shape.

Objective

We aimed to investigate the effects of gum chewing training on the occlusal force, masseter muscle thickness (MMT) and mandibular shape in healthy adults.

Methods

We conducted a prospective randomised controlled trial from January 2020 to September 2020 at the Yonsei University College of Dentistry. Fifty-eight participants were randomly assigned to the training and control groups. The training group chewed gum three times a day for 6 months, while the control group received no training. Changes in the maximum occlusal force and MMT were evaluated at baseline and after 1, 3 and 6 months. Changes in the mandibular shape were evaluated at baseline and after 6 months.

Results

The mean maximum occlusal force of the training group at 3 months was significantly higher than that at baseline, which was also significantly different from that in the control group (p < .001). As the maximum occlusal force increased, the occlusal contact area also increased (p = .020). There was no statistically significant difference in MMT or mandibular shape compared to the baseline.

Conclusion

Mastication training using gum increases maximum occlusal force due to an increase in occlusal contact area but has no effect on MMT or mandibular shape.

背景：通过咀嚼口香糖进行咀嚼肌训练很容易，而且能改善咀嚼肌功能和力量。然而，咀嚼肌活动和功能的增强可能会改变下颌骨的形状：我们旨在研究咀嚼口香糖训练对健康成年人咬合力、咀嚼肌厚度（MMT）和下颌骨形态的影响：我们于 2020 年 1 月至 2020 年 9 月在延世大学牙科学院进行了一项前瞻性随机对照试验。58名参与者被随机分配到训练组和对照组。训练组每天咀嚼口香糖三次，为期 6 个月，对照组不接受任何训练。在基线和 1、3、6 个月后，对最大咬合力和 MMT 的变化进行评估。在基线和 6 个月后评估下颌形状的变化：结果：训练组 3 个月后的平均最大咬合力明显高于基线时的平均最大咬合力，与对照组相比也有显著差异（p 结论：使用牙胶进行咀嚼训练可提高最大咬合力：使用牙胶进行咀嚼训练可增加咬合接触面积，从而增加最大咬合力，但对MMT或下颌骨形态没有影响。

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引用次数: 0

The Role of Astrocyte-Neuron Lactate Shuttle in Neuropathic Orofacial Pain 星形胶质细胞-神经元乳酸盐穿梭液在神经性口面痛中的作用

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-29 DOI: 10.1111/joor.13847

Yinyin Hu, Hequn Zou, Zhijun Zhong, Qi Li, Qinghong Zeng, Qian Ouyang, Xueliang Zou, Mengmeng Wang, Yaxing Luo, Dongyuan Yao

Background

Inhibition of astrocytic energy metabolism alleviates neuropathic pain.

Objectives

To explore whether astrocyte-neuron lactate shuttle (ANLS) played any role in neuropathic orofacial pain.

Methods

Rats with partial transection of the right infraorbital nerve (p-IONX) or sham operation were intrathecally injected with acetazolamide (a carbonic anhydrase inhibitor), bithionol (a soluble adenylyl cyclase inhibitor), α-cyano-4-hydroxycinnamic acid [α-CHCA, a monocarboxylate transporter (MCT) inhibitor] or vehicle once a day from postoperative day 1–14. The facial mechanical thresholds were tested on preoperative day 1 and 2 and postoperative days 1, 3, 5, 7, 10 and 14, expression of glucose transporters (GLUTs) and MCTs in the trigeminal subnucleus caudalis (Vc) were examined on the postoperative day 3 and neuronal activities in the Vc were examined in the p-IONX rats on postoperative days 3–5.

Results

Compared with the sham group, the mechanical thresholds in the p-IONX group were significantly reduced at postoperative days 1–7, and the number of astrocytes expressing GLUT1 and MCT1/4, and neurons expressing MCT2 was significantly increased on postoperative day 3. In the p-IONX groups, neurons in the Vc were sensitised, and acetazolamide, bithionol and α-CHCA reversed the central sensitisation, significantly increased the mechanical thresholds at postoperative days 1–7 and decreased the number of astrocytes expressing GLUT1 and MCT1/4, and neurons expressing MCT2 at postoperative day 3 compared with those in the vehicle-treated rats.

Conclusions

Inhibition of ANLS alleviates p-IONX-related neuronal, behavioural and immunohistochemical changes, which suggests that ANLS plays an important role in trigeminal neuropathic pain.

背景：抑制星形胶质细胞能量代谢可缓解神经病理性疼痛：抑制星形胶质细胞的能量代谢可缓解神经病理性疼痛：目的：探讨星形胶质细胞-神经元乳酸穿梭（ANLS）在神经病理性面痛中是否起作用：方法：从术后第1-14天开始，给右眶下神经部分横断（p-IONX）或假手术大鼠鞘内注射乙酰唑胺（一种碳酸酐酶抑制剂）、双硫醇（一种可溶性腺苷酸环化酶抑制剂）、α-氰基-4-羟基肉桂酸[α-CHCA，一种单羧酸盐转运体（MCT）抑制剂]或载体，每天一次。术前第 1、2 天和术后第 1、3、5、7、10 和 14 天测试面部机械阈值，术后第 3 天检测三叉神经尾下核（Vc）中葡萄糖转运体（GLUTs）和单羧酸盐转运体（MCTs）的表达，术后第 3-5 天检测 p-IONX 大鼠 Vc 中神经元的活动：结果：与假组相比，p-IONX 组大鼠的机械阈值在术后第 1-7 天显著降低，表达 GLUT1 和 MCT1/4 的星形胶质细胞数量以及表达 MCT2 的神经元数量在术后第 3 天显著增加。在 p-IONX 组中，Vc 中的神经元被致敏，而乙酰唑胺、双硫酚和 α-CHCA 逆转了中枢致敏，术后第 1-7 天的机械阈值明显增加，表达 GLUT1 和 MCT1/4 的星形胶质细胞数量以及表达 MCT2 的神经元数量在术后第 3 天减少：结论：抑制 ANLS 可减轻 p-IONX 相关的神经元、行为和免疫组化变化，这表明 ANLS 在三叉神经痛中发挥着重要作用。

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引用次数: 0

Impact of Hospital Dentistry on Patients' Food Intake Status in Convalescent Rehabilitation Ward 医院牙科对康复疗养病房病人食物摄入状况的影响。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-29 DOI: 10.1111/joor.13848

Tomohisa Ohno, Izumi Terada, Akiko Nomoto, Ichiro Fujishima, Yasuyuki Iwasa, Yoshiko Umeda, Daisuke Kanamori, Masako Kishima, Hideo Sakaguchi, Koichiro Matsuo, Yasutomo Motohashi, Kenichiro Ozaki, Shunsuke Minakuchi

Background

Treating oral problems with dentist intervention during hospitalisation may improve patients' food intake status.

Objectives

This study aimed to clarify whether convalescent rehabilitation ward inpatients in a hospital with hospital dentistry (HHD) had a better diet at discharge than those in a hospital without hospital dentistry (HNHD).

Methods

Retrospective observational study including inpatients with dental involvement in a HHD with dentists and dental hygienists and HNHD with dental hygienist and visiting dental service between 1 March and 31 August 2022. Data included age, sex, body mass index (BMI), Functional Independent Measure (FIM) motor and cognitive, Oral Health Assessment Tool (OHAT) score, Food Intake LEVEL Scale (FILS), whether the FILS ≥8 (indicating that patient eats also a non-texture-modified diet), remained and functional tooth numbers and speech language hearing therapist (SLHT) and dentist interventions. Comparisons between the two hospitals and factors that affected the FILS ≥8 were examined.

Results

A total of 333 and 89 inpatients were included in the HHD and HNHD groups, respectively. After propensity score matching, the HHD group had a significantly higher rate of FILS ≥8, functional tooth numbers at discharge, and SLHT and dentist intervention rates. The multivariable logistic regression analysis for propensity score matching participants showed that the significant independent variables for FILS ≥8 were age, BMI, FILS, FIM motor (all at admission) and SLHT and dentist interventions. Odds ratio for dentist intervention was 14.46 (95% CI: 4.36–48.01).

Conclusions

Dentists are necessary to improve patients' food intake status in convalescent rehabilitation wards.

背景：住院期间通过牙医干预治疗口腔问题可改善患者的食物摄入状况：住院期间通过牙医干预治疗口腔问题可改善患者的食物摄入状况：本研究旨在明确在有医院牙科（HHD）的医院中，康复疗养病房的住院患者出院时的饮食情况是否优于没有医院牙科（HNHD）的医院：方法：回顾性观察研究，包括2022年3月1日至8月31日期间在有牙医和牙科保健师的医院牙科康复病房以及有牙科保健师和上门牙科服务的医院牙科康复病房接受牙科治疗的住院患者。数据包括年龄、性别、体重指数（BMI）、运动和认知功能独立测量（FIM）、口腔健康评估工具（OHAT）评分、食物摄入水平量表（FILS）、食物摄入水平量表是否≥8（表明患者同时进食非质地改良饮食）、残留和功能性牙齿数量以及语言听力治疗师（SLHT）和牙医干预。研究了两家医院之间的比较以及影响 FILS ≥8 的因素：HHD组和HNHD组分别有333名和89名住院患者。经过倾向得分匹配后，HHD 组的 FILS ≥8、出院时的功能性牙齿数量、SLHT 和牙医干预率均明显高于 HNHD 组。对倾向得分匹配参与者进行的多变量逻辑回归分析表明，FILS ≥8 的重要自变量是年龄、体重指数、FILS、FIM 运动（均在入院时）以及 SLHT 和牙医干预。牙医干预的比值比为 14.46（95% CI：4.36-48.01）：结论：牙医对于改善康复疗养病房患者的食物摄入状况十分必要。

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引用次数: 0

Association between psychological traits and occlusal tactile acuity of healthy individuals 健康人的心理特征与咬合触觉敏锐度之间的关系。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-29 DOI: 10.1111/joor.13828

Gabriella Coppola, Ambrosina Michelotti, Vittorio Simeon, Michail Koutris, Frank Lobbezoo, Rosaria Bucci

Objectives

Tactile acuity is a somatosensory measure of the extent to which humans can discern tactile stimuli. It is influenced by how peripheral signals are processed centrally. In the oral cavity, Occlusal Tactile Acuity (OTA) is the ability to perceive minimal thicknesses between antagonist teeth. The aim of the current study was to assess the association between psychological traits and OTA of otherwise healthy individuals.

Methods

Sixty-three volunteers (32 males; mean age ± SD: 24.6 ± 2.7 years) participated in this study. Somatosensory amplification, anxiety, depression, physical symptoms and pain catastrophizing were scored using questionnaires, and subgroups of severity were created per variable based on cut-offs. OTA was measured using 9 aluminium foils with thickness (ranging from 8 to 72 μm) and one sham test (without foil). Each thickness was tested 10 times in random order, the participants were instructed to report whether they felt the foil between their molars and the mean percentage of correct answers was computed. A linear mixed model was used with OTA as a dependent variable and psychological domain as an independent variable.

Results

Significantly different OTA was observed among the anxiety subgroups (p = .003), supporting a decreased perception of thicknesses 24 and 32 μm (p = .018 and p < .001, respectively) in participants with moderate/severe anxiety compared to those with no/mild anxiety. Significantly different OTA was also observed among the pain catastrophizing subgroups (p = .008), showing decreased perception of thicknesses 32 and 40 μm (p < .001 and p = .007, respectively) in severe catastrophizing levels, compared to no/mild catastrophizing levels. No significant differences were observed for the other variables.

Conclusions

Healthy adults with increased anxiety or pain catastrophizing levels show decreased interdental acuity as compared to participants with minor or no psychological impairment.

目标触觉敏锐度是一种体感测量方法，用于衡量人类对触觉刺激的分辨能力。它受中枢如何处理外周信号的影响。在口腔中，咬合触觉敏锐度（OTA）是指感知拮抗牙之间最小厚度的能力。本研究旨在评估健康人的心理特征与咬合触觉敏锐度之间的关系：63名志愿者（32名男性；平均年龄（± SD）：24.6±2.7岁）参加了此次研究。通过问卷对躯体感觉放大、焦虑、抑郁、躯体症状和疼痛灾难化进行评分，并根据临界值对每个变量的严重程度进行分组。测量 OTA 时使用了 9 种厚度（从 8 微米到 72 微米不等）的铝箔和一种假测试（不使用铝箔）。每种厚度随机测试 10 次，要求参与者报告是否感觉到臼齿间的铝箔，并计算正确答案的平均百分比。采用线性混合模型，以 OTA 为因变量，心理领域为自变量：结果：在焦虑亚组中观察到明显不同的 OTA（p = .003），支持对 24 和 32 μm 厚度的感知下降（p = .018 和 p 结论：焦虑或疼痛增加的健康成人对臼齿之间的金属箔的感知下降：焦虑或疼痛灾难化程度增加的健康成年人与心理障碍轻微或无心理障碍的参与者相比，牙间隙敏锐度有所下降。

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引用次数: 0

Efficacy of hyaluronic acid in temporomandibular disorders evaluated with diagnostic criteria for temporomandibular disorders (DC/TMD). 根据颞下颌关节紊乱症（DC/TMD）诊断标准评估透明质酸对颞下颌关节紊乱症的疗效。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-29 DOI: 10.1111/joor.13840

Pankaj Kukreja, Bhavna Jha Kukreja, Maria Maddalena Marrapodi, Vincenzo Ronsivalle, Marco Cicciù, Giuseppe Minervini

Background: The study aimed to retrospectively assess the efficacy of hyaluronic acid (HA) in managing temporomandibular disorders (TMD) using the diagnostic criteria for temporomandibular disorders (DC/TMD). There has been an ongoing debate regarding the effectiveness of HA as a treatment option for TMD, which necessitated a thorough evaluation.

Methods: The review adhered to PRISMA guidelines conducted across eight different databases, including PubMed, Embase, Web of Science, Cochrane Library, Scopus, ScienceDirect, PsycINFO and CINAHL. The selection criteria included studies that evaluated the efficacy of HA in TMD patients, utilised DC/TMD, and were published in English. Data extraction and quality assessment were performed independently by two reviewers. ROB-2 tool was employed to assess methodological quality of the assessed studies.

Results: A total of 10 studies met the inclusion criteria. They demonstrated that HA was effective in improving various symptoms of TMD, such as pain, mouth opening and joint sounds over control group. But on the other end, platelet-rich plasma (PRP) was found to be better than HA intervention in alleviation of TMD symptoms. However, the degree of improvement varied across the studies. Some studies reported adverse effects, but these were typically minor and transient. Risk of bias assessment was low in all the included studies.

Conclusion: The findings suggest that HA can be an effective treatment for TMD when evaluated with DC/TMD. However, the variation in effectiveness across studies indicates the need for individualised treatment planning and careful monitoring of adverse effects. Further research is needed to refine the treatment protocols and understand the long-term effectiveness and safety of HA in TMD management.

研究背景该研究旨在根据颞下颌关节紊乱症（DC/TMD）的诊断标准，回顾性评估透明质酸（HA）治疗颞下颌关节紊乱症（TMD）的疗效。关于透明质酸治疗 TMD 的有效性一直存在争议，因此有必要对其进行全面评估：综述遵循 PRISMA 准则，在 PubMed、Embase、Web of Science、Cochrane Library、Scopus、ScienceDirect、PsycINFO 和 CINAHL 等八个不同的数据库中进行。选择标准包括评估 HA 对 TMD 患者疗效的研究、使用 DC/TMD 的研究以及以英语发表的研究。数据提取和质量评估由两名审稿人独立完成。采用ROB-2工具评估所评估研究的方法学质量：共有 10 项研究符合纳入标准。这些研究表明，与对照组相比，HA 能有效改善 TMD 的各种症状，如疼痛、张口和关节声。但另一方面，在缓解 TMD 症状方面，富血小板血浆（PRP）的效果优于 HA 干预疗法。不过，不同研究的改善程度各不相同。一些研究报告了不良反应，但这些不良反应通常很轻微，而且是一过性的。所有纳入研究的偏倚风险评估均较低：研究结果表明，在与 DC/TMD 一起评估时，HA 可以有效治疗 TMD。然而，不同研究的疗效存在差异，这表明需要制定个性化的治疗计划并仔细监测不良反应。需要进一步开展研究，以完善治疗方案，了解 HA 在 TMD 治疗中的长期有效性和安全性。

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引用次数: 0

Changes in Craniofacial Morphology Induced by Unilateral Nasal Obstruction in Mice of Different Ages 不同年龄小鼠单侧鼻腔阻塞引起的颅面形态变化

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-29 DOI: 10.1111/joor.13849

Yun Hu, Hegang Li

Background

Nasal obstruction in humans leads to mouth breathing and subsequent hypoxia in the entire body. Furthermore, nasal obstruction in growing children affects craniofacial growth and development.

Objective

To investigate the effects of unilateral nasal obstruction (UNO) on craniofacial growth in mice of different ages, particularly on the morphology of the nasomaxillary complex and mandible.

Methods

Mice aged 3, 6 and 12 weeks were selected as representatives of juvenile, adolescent and adult stages, respectively. A total of 30 male C57BL/6J mice (10 mice each at the ages of 3, 6 and 12 weeks) were used in this study for a 3-week experiment. The mice in each age stage were randomly and evenly assigned to either the control group (C3+3, C6+3 and C12+3) or the experimental group (E3+3, E6+3 and E12+3). The UNO model in experimental group was constructed by plugging the mouse's left nostril, thereby disrupting its normal nasal breathing pattern and inducing hypoxia. The control group underwent the sham procedure. After 3 weeks, the length, width and height of the cranium, nasomaxillary complex and mandible of each group were measured on two-dimensional images constructed by micro-computed tomography. Furthermore, the impact of UNO on mouse growth was evaluated through the measurement of femoral length.

Results

In juvenile mice, UNO inhibited the growth of cranial width, cranial height and mandibular length. In adolescent mice, UNO impeded the growth of the femoral length, cranial length, nasomaxillary length and mandibular length. In adult mice, no significant negative effects of UNO on craniofacial growth were found.

Conclusion

Referring to the experimental results, in addition to actively treating nasal obstruction in patients, it is important to monitor the growth of the mandible in juveniles, as well as the nasomaxillary and mandibular growth in adolescents during orthodontic clinical practice.

背景：人类鼻塞会导致口呼吸，进而导致全身缺氧。此外，生长期儿童的鼻阻塞也会影响颅面的生长和发育：研究单侧鼻阻塞（UNO）对不同年龄小鼠颅面生长的影响，尤其是对鼻颌复合体和下颌骨形态的影响：方法：分别选择 3、6 和 12 周龄的小鼠作为幼年、青春期和成年阶段的代表。本研究共使用了 30 只雄性 C57BL/6J 小鼠（3、6 和 12 周龄各 10 只）进行为期 3 周的实验。每个年龄阶段的小鼠被随机平均分配到对照组（C3+3、C6+3 和 C12+3）或实验组（E3+3、E6+3 和 E12+3）。实验组的 UNO 模型是通过堵塞小鼠的左鼻孔，从而破坏其正常的鼻呼吸模式并诱导缺氧。对照组采用假手术。3 周后，通过微型计算机断层扫描构建的二维图像测量各组小鼠头颅、鼻颌复合体和下颌骨的长度、宽度和高度。此外，还通过测量股骨长度评估了 UNO 对小鼠生长的影响：结果：在幼年小鼠中，UNO 抑制了颅宽、颅高和下颌长度的增长。在青春期小鼠中，UNO 会阻碍股长、颅长、鼻颌长和下颌长的生长。结论：根据实验结果，在正畸临床实践中，除了积极治疗患者的鼻阻塞外，监测青少年下颌骨的生长以及鼻颌和下颌的生长也很重要。

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引用次数: 0

Genetic susceptibility to temporomandibular joint involvement in juvenile idiopathic arthritis 幼年特发性关节炎颞下颌关节受累的遗传易感性。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-27 DOI: 10.1111/joor.13834

P. Niibo, T. Nikopensius, T. Jagomägi, Ü. Voog, T. Haller, N. Tõnisson, A. Metspalu, M. Saag, C. Pruunsild

Background

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. Temporomandibular joint (TMJ) is among the most commonly affected joints in JIA patients. When JIA involves the TMJ, it may affect condylar growth in the joint; therefore, JIA patients are at risk of unfavourable long-term outcomes from associated joint damage. If undetected, TMJ involvement can lead to various functional disabilities such as reduced mandibular mobility and disorders of the mastication muscles. Limitations in sagittal and vertical mandibular growth can result in micrognathia and anterior open bite with aesthetic and functional restrictions.

Objective

Genetic factors may play a role in determining which individuals are more prone to develop TMJ disorders or in predicting the severity of the disease process. Therefore, we applied a GWAS approach to identify loci associated with TMJ involvement in a sample of Estonian patients with JIA. Our aim was to address the potential role of genetic susceptibility factors in TMJ-JIA, a condition not previously studied in this context.

Methods

The case group consisted of 55 JIA patients with TMJ involvement and 208 patients without TMJ involvement comprised the control group. The entire cohort was genotyped using the Illumina HumanOmniExpress BeadChip arrays. Imputation was performed using a nationwide reference panel obtained of 2240 individuals whose data were obtained from the Estonian Biobank.

Results

We identified six loci as being associated with the risk of TMJ-JIA in Estonian JIA patients. The strongest associations were identified at CD6 rs3019551 (P = 3.80 × 10⁻⁶), SLC26A8/MAPK14 rs9470191 (P = 6.15 × 10⁻⁶), NLRP3 rs2056795 (P = 8.91 × 10⁻⁶) and MAP2K4 rs7225328 (P = 1.64 × 10⁻⁵).

Conclusion

This study provides first insights into the risk-associated loci between JIA and its manifestation in the TMJ. The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that render the TMJ susceptible to involvement by JIA in Estonian patients.

背景：幼年特发性关节炎（JIA）是儿童时期最常见的慢性风湿病。颞下颌关节（TMJ）是 JIA 患者最常受影响的关节之一。当 JIA 累及颞下颌关节时，可能会影响关节内的髁突生长；因此，JIA 患者有可能因相关的关节损伤而导致不利的长期后果。如果未被发现，颞下颌关节受累可导致各种功能障碍，如下颌骨活动度降低和咀嚼肌功能紊乱。下颌骨矢状和垂直生长受限可导致小颌畸形和前方开放性咬合，造成美观和功能上的限制：遗传因素可能在决定哪些人更容易患颞下颌关节疾病或预测疾病过程的严重程度方面发挥作用。因此，我们采用基因组学分析方法，在爱沙尼亚 JIA 患者样本中找出与颞下颌关节受累相关的基因位点。我们的目的是研究遗传易感因素在颞下颌关节-JIA 中的潜在作用，这种情况以前从未研究过：病例组包括 55 名颞下颌关节受累的 JIA 患者，对照组包括 208 名无颞下颌关节受累的患者。使用 Illumina HumanOmniExpress BeadChip 芯片对整个群体进行了基因分型。利用从爱沙尼亚生物库中获得数据的 2240 人组成的全国性参考面板进行了推算：结果：我们确定了六个位点与爱沙尼亚 JIA 患者颞下颌关节-JIA 的风险有关。其中，CD6 rs3019551（P = 3.80 × 10-6）、SLC26A8/MAPK14 rs9470191（P = 6.15 × 10-6）、NLRP3 rs2056795（P = 8.91 × 10-6）和 MAP2K4 rs7225328（P = 1.64 × 10-5）的相关性最强：本研究首次揭示了 JIA 与颞下颌关节表现之间的风险相关位点。所报告的基因位点涉及与免疫学相关的分子通路，很可能代表了使爱沙尼亚患者的颞下颌关节易受 JIA 影响的基因组区域。

{"title":"Genetic susceptibility to temporomandibular joint involvement in juvenile idiopathic arthritis","authors":"P. Niibo, T. Nikopensius, T. Jagomägi, Ü. Voog, T. Haller, N. Tõnisson, A. Metspalu, M. Saag, C. Pruunsild","doi":"10.1111/joor.13834","DOIUrl":"10.1111/joor.13834","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic condition of childhood. Temporomandibular joint (TMJ) is among the most commonly affected joints in JIA patients. When JIA involves the TMJ, it may affect condylar growth in the joint; therefore, JIA patients are at risk of unfavourable long-term outcomes from associated joint damage. If undetected, TMJ involvement can lead to various functional disabilities such as reduced mandibular mobility and disorders of the mastication muscles. Limitations in sagittal and vertical mandibular growth can result in micrognathia and anterior open bite with aesthetic and functional restrictions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Genetic factors may play a role in determining which individuals are more prone to develop TMJ disorders or in predicting the severity of the disease process. Therefore, we applied a GWAS approach to identify loci associated with TMJ involvement in a sample of Estonian patients with JIA. Our aim was to address the potential role of genetic susceptibility factors in TMJ-JIA, a condition not previously studied in this context.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The case group consisted of 55 JIA patients with TMJ involvement and 208 patients without TMJ involvement comprised the control group. The entire cohort was genotyped using the Illumina HumanOmniExpress BeadChip arrays. Imputation was performed using a nationwide reference panel obtained of 2240 individuals whose data were obtained from the Estonian Biobank.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We identified six loci as being associated with the risk of TMJ-JIA in Estonian JIA patients. The strongest associations were identified at <i>CD6</i> rs3019551 (<i>P</i> = 3.80 × 10<sup>−6</sup>), <i>SLC26A8</i>/<i>MAPK14</i> rs9470191 (<i>P</i> = 6.15 × 10<sup>−6</sup>), <i>NLRP3</i> rs2056795 (<i>P</i> = 8.91 × 10<sup>−6</sup>) and <i>MAP2K4</i> rs7225328 (<i>P</i> = 1.64 × 10<sup>−5</sup>).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides first insights into the risk-associated loci between JIA and its manifestation in the TMJ. The reported loci are involved in molecular pathways of immunological relevance and likely represent genomic regions that render the TMJ susceptible to involvement by JIA in Estonian patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"51 11","pages":"2445-2451"},"PeriodicalIF":3.1,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of masticatory performance and oral hygiene status using cream-type denture adhesives and home liners: A cross-sectional study using propensity-score matching 使用膏状义齿粘合剂和家用衬垫的咀嚼功能和口腔卫生状况比较：使用倾向分数匹配法进行的横断面研究。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-22 DOI: 10.1111/joor.13839

Kohei Yamaguchi, Yohei Hama, Yoshiyuki Sasaki, Hitomi Soeda, Mitsuzumi Okada, Ryota Futatsuya, Mayuko Matsuzaki, Shunsuke Minakuchi

Background

Differences in the effects of cream-type denture adhesives and home liners remain unclear.

Objective

This cross-sectional study aimed to clarify the differences in the oral-hygiene status and masticatory performance between participants using cream-type denture adhesives and those using home liners.

Methods

Masticatory performance with and without cream-type denture adhesives and home liners was evaluated using colour-changeable chewing gum. Oral hygiene was assessed using the tongue coating index (TCI). Propensity-score matching was performed using oral moisture, presence of palatal or mandibular protuberances, type of residual ridge, denture type (complete or partial denture), and denture retention as background factors. Wilcoxon signed-rank test was used to examine the differences in masticatory performance with and without cream-type denture adhesives and home liners and differences in masticatory performance and TCI between the cream-type denture adhesive and home-liner groups.

Results

This study included 38 and 40 cream-type adhesive and home-liner users, respectively, and 17 pairs were obtained after propensity-score matching. The Wilcoxon signed-rank tests showed that masticatory performance was significantly different with and without the use of home liners, and higher values were obtained with the use of home-liners. However, the cream-type denture adhesive and home-liner groups showed no significant differences in terms of the change in masticatory performance with the use of them. Furthermore, Wilcoxon signed-rank tests showed that TCI values were significantly high in the cream-type adhesive group.

Conclusion

The findings in this study suggest that home liners improve masticatory performance and that participants regularly using cream-type denture adhesives have poorer oral hygiene.

背景：膏状义齿粘接剂和家用衬垫的效果差异仍不明确：本横断面研究旨在阐明使用乳脂型义齿粘合剂和使用家庭衬垫的参与者在口腔卫生状况和咀嚼功能方面的差异：使用可变色口香糖对使用和未使用乳脂型义齿粘合剂和家用衬垫的参与者的咀嚼能力进行评估。口腔卫生采用舌苔指数（TCI）进行评估。以口腔湿度、是否存在腭或下颌突起、残嵴类型、义齿类型（全口义齿或局部义齿）和义齿固位情况为背景因素，进行倾向分数匹配。采用Wilcoxon符号秩检验来检验使用和不使用乳脂型义齿粘接剂和家庭衬垫的咀嚼功能差异，以及乳脂型义齿粘接剂组和家庭衬垫组之间咀嚼功能和TCI的差异：本研究分别纳入了 38 和 40 名乳脂型义齿粘合剂和家用衬垫使用者，经过倾向分数匹配后得到了 17 对研究对象。Wilcoxon 符号秩检验显示，使用和不使用家庭衬垫的咀嚼功能有显著差异，使用家庭衬垫的咀嚼功能值更高。然而，乳膏型义齿粘合剂组和家庭衬垫组在使用后的咀嚼功能变化方面没有明显差异。此外，Wilcoxon 符号秩检验显示，奶油型粘合剂组的 TCI 值明显偏高：本研究结果表明，家用衬垫可改善咀嚼功能，而经常使用乳脂型义齿粘合剂的参与者口腔卫生较差。

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引用次数: 0

Identifying phenotypes in persons with temporomandibular disorders using latent class analyses 利用潜类分析确定颞下颌关节紊乱症患者的表型：颞下颌关节紊乱与表型。

IF 3.1 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of oral rehabilitation

Pub Date : 2024-08-22 DOI: 10.1111/joor.13837

Elisabeth Heggem Julsvoll, Birgitte Lawaetz Myhrvold, Knut Waagan, Nina Køpke Vøllestad, Hilde Stendal Robinson

Background

The heterogeneity of persons with temporomandibular disorders (TMD) and the lack of effective treatments have called for a biopsychosocial model and the development of a more personalised treatment approach. Emphasis on phenotypes might be a beneficial approach.

Objective

Identifying phenotypes among persons with TMD using potential prognostic factors, including personal characteristics and responses to clinical tests. Additionally, examining the distribution of TMD diagnoses within the identified phenotypes.

Methods

A cross-sectional study including 208 persons (85% females) seeking physiotherapy for problems in the temporomandibular area. All participants were examined clinically and answered questionnaires electronically. The phenotypes were identified using latent class analysis based on seven potential prognostic factors selected within pain, function and psychological domains. Table analysis was used to explore the distribution of TMD diagnoses within the identified phenotypes.

Results

Most participants fit into one of three identified phenotypes. Phenotype 1 (32%) was characterised by functional disability, low psychosocial scores and low risk for developing chronicity and future work disability; Phenotype 2 (29%) by parafunctional habits, low psychosocial score and seeking treatment to reduce pain; and Phenotype 3 (39%) by high levels of mental distress, fear avoidance and a large risk of future work disability. Intra-articular disorders dominated Phenotype 1, myalgia and TMD-related headache Phenotype 2, while Phenotype 3 included all the different TMD diagnoses.

Conclusion

The knowledge about the three identified phenotypes might be useful for clinicians treating persons with TMD and for the development of preventive strategies and more personalised treatment.

背景：颞下颌关节紊乱症（TMD）患者的异质性和有效治疗方法的缺乏，要求采用生物-心理-社会模式，并开发更加个性化的治疗方法。强调表型可能是一种有益的方法：利用潜在的预后因素，包括个人特征和对临床测试的反应，确定 TMD 患者的表型。此外，研究已确定的表型中 TMD 诊断的分布情况：这是一项横断面研究，共有 208 人（85% 为女性）因颞下颌区域的问题寻求物理治疗。所有参与者均接受了临床检查并回答了电子问卷。根据在疼痛、功能和心理领域中选择的七个潜在预后因素，采用潜类分析法确定了表型。采用表格分析法探讨了已确定表型中 TMD 诊断的分布情况：结果：大多数参与者符合三种已确定表型中的一种。表型 1（32%）的特点是功能性残疾、社会心理评分低、发展为慢性病和未来工作残疾的风险低；表型 2（29%）的特点是副功能性习惯、社会心理评分低、寻求治疗以减轻疼痛；表型 3（39%）的特点是精神压力大、回避恐惧、未来工作残疾的风险高。表型 1 以关节内疾病为主，表型 2 以肌痛和 TMD 相关头痛为主，而表型 3 则包括所有不同的 TMD 诊断：关于这三种表型的知识可能对治疗 TMD 患者的临床医生有用，并有助于制定预防策略和进行更个性化的治疗。

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引用次数: 0