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Relationship Between Fear of Childbirth and Oral Health-Related Quality of Life in Pregnant Women: The Mediating Effect of Pregnancy Anxiety. 分娩恐惧与孕妇口腔健康相关生活质量的关系:妊娠焦虑的中介作用
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-17 DOI: 10.1111/joor.13897
Yujia Chen, Jing Zhao, Jin Zheng, Zhijie Zou, Xiaoli Chen

Background: Psychosocial health affects oral health-related quality of life. Pregnancy, as a special time for women, produces significant psychological changes. However, the relationship between mental health during pregnancy and oral health-related quality of life is unclear.

Objective: The study aims to explore the association between fear of childbirth and investigate the mediating effect of pregnancy anxiety.

Methods: Using a cross-sectional design, 478 pregnant women were recruited and evaluated using the Fear of Birth Scale, the Pregnancy-Related Anxiety Questionnaire and the Oral Health Impact Profile-14. Multiple linear regressions were performed to evaluate the relationship between fear of childbirth and oral health-related quality of life. PROCESS software was applied to assess the mediating effect of pregnancy anxiety.

Results: Both fear of childbirth and pregnancy anxiety were negative correlation with oral health-related quality. Pregnancy anxiety mediated 40% of the association between fear of childbirth and oral health-related quality of life (β = 0.072, SE = 0.030, 95% CI [0.015, 0.131]).

Conclusions: Pregnancy anxiety mediates the relationship between fear of childbirth and oral health-related quality of life in pregnant women. To improve the oral health-related quality of life among pregnant women, relevant healthcare workers should actively help pregnant women to improve psychological health.

背景:心理社会健康影响口腔健康相关的生活质量。孕期作为女性的特殊时期,会产生显著的心理变化。然而,孕期心理健康与口腔健康相关生活质量之间的关系尚不清楚。目的:探讨分娩恐惧与妊娠焦虑的关系,探讨妊娠焦虑的中介作用。方法:采用横断面设计,招募478名孕妇,并使用出生恐惧量表、妊娠相关焦虑问卷和口腔健康影响概况-14进行评估。采用多元线性回归来评估分娩恐惧与口腔健康相关生活质量之间的关系。采用PROCESS软件评估妊娠焦虑的中介作用。结果:分娩恐惧和妊娠焦虑与口腔健康相关质量均呈负相关。怀孕焦虑介导了分娩恐惧与口腔健康相关生活质量之间40%的关联(β = 0.072, SE = 0.030, 95% CI[0.015, 0.131])。结论:妊娠焦虑在分娩恐惧与孕妇口腔健康相关生活质量之间起中介作用。为提高孕妇口腔健康相关生活质量,相关医护人员应积极帮助孕妇改善心理健康。
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引用次数: 0
Pleiotrophin Prevents H2O2-Induced Senescence of Dental Pulp Stem Cells 多营养蛋白预防h2o2诱导的牙髓干细胞衰老。
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-12 DOI: 10.1111/joor.13918
Chang Liu, Wanzhen Lei, Lili Zhang, Chen Zhang, Runtao Gao, Luyuan Jin
<div> <section> <h3> Background</h3> <p>Dental pulp stem cells (DPSCs) are widely used in research on dental tissue regeneration and systemic disease treatment. However, the oxidative microenvironment often causes cellular senescence, leading to decreased function. Our previous study demonstrated that pleiotrophin (PTN), a secreted extracellular matrix-associated protein, could rescue the proliferative capacity and osteogenic differentiation of replicative senescent DPSCs.</p> </section> <section> <h3> Objective</h3> <p>This study aimed to explore the influence and mechanism of PTN on dental pulp stem cells under H<sub>2</sub>O<sub>2</sub>-induced oxidative microenvironment.</p> </section> <section> <h3> Materials and Methods</h3> <p>DPSCs isolated from human third molars were treated with 100 μm H<sub>2</sub>O<sub>2</sub> for 4 h, mimicking the oxidative microenvironment. To investigate the influence of PTN on DPSC under H<sub>2</sub>O<sub>2</sub>-induced oxidative microenvironment, 50 pg/mL PTN was added in the culture medium for 48 h. RT-qPCR, western blotting, SA-β-gal staining, intracellular ROS production and immunofluorescence staining assays were used to analyse the cellular senescence, osteogenic differentiation capacity, oxidative stress conditions and possible mechanism.</p> </section> <section> <h3> Results</h3> <p>H<sub>2</sub>O<sub>2</sub> treatment increased the ratio of SA-β-gal-positive DPSCs and upregulated the senescence-related gene expression, including <i>P53, P21</i> and <i>P16</i>. PTN pretreatment downregulated the ratio of SA-β-gal-positive DPSCs and the expression of these genes. Besides, PTN pretreatment partially reversed the H<sub>2</sub>O<sub>2</sub>-induced decreased osteogenic differentiation potential of DPSCs, total antioxidant capacity and <i>Nrf2</i> and <i>HO-1</i> mRNA expression in DPSCs. Western blotting and immunofluorescent staining results indicated that PTN pretreatment enhanced the Nrf2 nuclear translocation under oxidative stress conditions and observable higher fluorescence signals in the nucleus denoted PTN and Nrf2 colocalisation. Western blotting results showed that PTN reversed the decreased expression of p-AKT in the H<sub>2</sub>O<sub>2−</sub>induced oxidative environment. However, the PI3K inhibitor LY294002 blocked the upregulated levels of total Nrf2. Immunofluorescence staining displayed that LY294002 also inhibited the nuclear translocation of Nrf2 which was enhanced under PTN pretreatment.</p> </section> <section> <h3> Conclusions</h3> <p>This study demonstrated that PTN could prevent senesce
背景:牙髓干细胞(DPSCs)被广泛应用于牙科组织再生和系统性疾病治疗研究。然而,氧化微环境往往会引起细胞衰老,导致功能下降。我们之前的研究表明,细胞外基质相关分泌蛋白褶皱素(PTN)可以挽救复制衰老DPSCs的增殖能力和成骨分化能力:本研究旨在探讨H2O2诱导的氧化微环境下PTN对牙髓干细胞的影响和机制:从人类第三磨牙中分离出的牙髓干细胞经100 μm H2O2处理4 h,模拟氧化微环境。为了研究在 H2O2 诱导的氧化微环境下 PTN 对 DPSC 的影响,在培养基中加入 50 pg/mL PTN 培养 48 小时。采用RT-qPCR、Western印迹、SA-β-gal染色、细胞内ROS产生和免疫荧光染色等方法分析了细胞衰老、成骨分化能力、氧化应激条件和可能的机制:结果:H2O2处理增加了SA-β-gal阳性DPSCs的比例,并上调了衰老相关基因的表达,包括P53、P21和P16。PTN 预处理可下调 SA-β-gal 阳性 DPSCs 的比例和这些基因的表达。此外,PTN还能部分逆转H2O2诱导的DPSCs成骨分化潜能下降、DPSCs总抗氧化能力下降以及Nrf2和HO-1 mRNA的表达。Western印迹和免疫荧光染色结果表明,PTN预处理增强了氧化应激条件下Nrf2的核转位,核内可观察到更高的荧光信号,表明PTN和Nrf2共定位。Western 印迹结果表明,PTN 逆转了 p-AKT 在 H2O2 诱导的氧化环境中的表达。然而,PI3K 抑制剂 LY294002 阻断了总 Nrf2 水平的上调。免疫荧光染色显示,LY294002还抑制了Nrf2的核转位,而Nrf2的核转位在PTN预处理后得到了增强:本研究表明,PTN主要通过与Nrf2结合并增强其核转位来防止H2O2诱导的DPSCs衰老损伤。
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引用次数: 0
Sleep-Disordered Breathing and Dimensions of The Maxillary Dental Arch and Hard Palate in Children With Class II and Large Overjet—A Case-Control Study II级及大复盖患儿睡眠呼吸障碍与上颌牙弓及硬腭尺寸的关系——病例对照研究
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-08 DOI: 10.1111/joor.13911
Camilla Hansen, Agneta Markström, Merete Bakke, Liselotte Sonnesen

Background

Class II occlusion is associated with narrow dimensions of the maxillary dental arch and hard palate (maxillary dimensions), which may increase the risk of narrow upper airways and sleep-disordered breathing (SDB).

Objectives

The aim was to compare maxillary dental arch and hard palate dimensions in children with Class II and large overjet ≥ 6 mm (study group) to a control group with neutral occlusion and to examine the relation between SDB and maxillary dimensions.

Methods

The study group included 37 children (19 boys; 18 girls; median age 12.3 years) and the control group included 32 children (16 boys; 16 girls; median age 12.2 years). SDB was assessed by respiratory polygraphy, the distances between maxillary canines and first permanent molars were measured by intraoral scans and the general relation between SDB and maxillary dimensions was analysed.

Results

Significantly smaller distances between both canines and first molars (p ≤ 0.001) were found in the study group. No significant differences in dimensions of the hard palate or SDB were found between the groups but the snore index tended to be higher in the study group (p = 0.051). No general significant associations between SDB measurements and maxillary dimensions were found in the total group of participants.

Conclusions

Significantly reduced transversal dimensions of the maxillary dental arch were found in the study group with Class II occlusion compared to controls. No significant difference regarding dimensions of the hard palate or SDB between the groups was found nor between SDB and maxillary dimensions. However, intraoral scans may be useful in risk assessment of early signs of paediatric SDB in orthodontic patients.

Trial Registration

ClinicalTrials.gov identifier: NCT04964830

背景:II类咬合与上颌牙弓和硬腭尺寸狭窄(上颌尺寸)相关,可能增加上呼吸道狭窄和睡眠呼吸障碍(SDB)的风险。目的:比较ⅱ类和大牙弓≥6 mm儿童(研究组)与中性咬合对照组的上颌牙弓和硬腭尺寸,并探讨SDB与上颌尺寸的关系。方法:研究组纳入37例儿童(男孩19例;18岁女孩;中位年龄12.3岁),对照组包括32名儿童(16名男孩;16岁女孩;中位年龄12.2岁)。采用呼吸测谎法评估SDB,口内扫描测量上颌犬齿与第一恒磨牙之间的距离,并分析SDB与上颌尺寸的一般关系。结果:研究组的犬齿与第一磨牙之间的距离明显减小(p≤0.001)。两组间硬腭、SDB尺寸差异无统计学意义,但研究组打鼾指数有较高的趋势(p = 0.051)。在所有参与者中,SDB测量值与上颌尺寸之间没有普遍的显著关联。结论:与对照组相比,II类咬合组上颌牙弓横向尺寸明显减小。两组间硬腭或深潜骨的尺寸及深潜骨与上颌的尺寸均无显著差异。然而,口腔内扫描可能有助于评估正畸患者儿童SDB的早期症状。试验注册:ClinicalTrials.gov标识符:NCT04964830。
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引用次数: 0
Correlates and Comparability of Two Devices for Measuring Bite Force in Dentate Health Volunteers 两种牙齿健康志愿者咬合力测量装置的相关性和可比性。
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-12-04 DOI: 10.1111/joor.13914
Murali Srinivasan, Bita Tahoury, Lisa Takeshita, Yasmin Milhomens Moreira, Júlia Siqueira Rodrigues Pavan, Cláudio Rodrigues Leles

Objective

This study aimed to correlate the bite/occlusal force measurements obtained through two methods: a hydraulic pressure gauge with a biting transducer (GM-10), and a computer-assisted device that records occlusal force on a pressure-sensitive film (Prescale II).

Methods

Healthy, dentate volunteers were recruited. Participants' demographic data included age, sex, number of teeth present, presence of oral pain, history of prior orthodontic treatment and presence of parafunction. Bite/occlusal force measurements were recorded for each participant using the GM-10 and the Prescale II devices. Linear Mixed-effect model regression was performed with the significance set at p < 0.05.

Results

Forty-six volunteers (women = 25, men = 21; mean-age = 30.9 ± 9.3 years) participated. 54.3% and 34.8% presented with 28 and 29–32 teeth, respectively. 60.9% and 26.1% of the participants reported previous orthodontic treatment and oral parafunction. The overall mean GM-10 measurements recorded were 333.0 ± 192, 276 ± 167, 208 ± 134, 142 ± 103 Newtons, for the 2nd and 1st molars, 2nd and 1st premolars, respectively. GM-10 measurements were associated with the tooth position (p < 0.001) and the number of teeth (p < 0.001). The mean Prescale II measurements obtained with and without filter were 826 ± 594 and 1049 ± 595 Newtons, respectively, which were positively correlated with the occlusal contact area (r = 0.765; p < 0.001) and GM-10 (r = 0.245; p = 0.019). The regression analysis for dependent repeated data confirmed the significant effect of the GM-10 measurements (bite force) and the occlusal contact area on the Prescale II measurements.

Conclusion

Within the limitations of this study, it can be concluded that the correlation between bite force measurements carried out by GM-10 and Dental Prescale II was low and may not be considered interchangeable methods. The maximum bite force measured in isolated point contacts was a predictive factor of the occlusal force distributed over the entire arch. Further studies are warranted to explore this influence in the clinical implications of these findings.

目的:本研究旨在将通过两种方法获得的咬合/咬合力测量结果联系起来:一种是带有咬合传感器的液压压力表(GM-10),另一种是在压敏薄膜上记录咬合力的计算机辅助设备(Prescale II)。方法:招募健康的有牙齿的志愿者。参与者的人口统计数据包括年龄、性别、牙齿数量、口腔疼痛的存在、以前的正畸治疗史和功能异常的存在。使用GM-10和precale II设备记录每位参与者的咬合力/咬合力测量。采用线性混合效应模型回归,显著性集为p。结果:46名志愿者(女性= 25,男性= 21;平均年龄= 30.9±9.3岁。牙数28、29 ~ 32牙者分别占54.3%和34.8%。60.9%和26.1%的参与者报告了以前的正畸治疗和口腔功能异常。第二、第一磨牙、第二、第一前磨牙的GM-10平均测量值分别为333.0±192、276±167、208±134、142±103牛顿。GM-10测量与牙齿位置相关(p结论:在本研究的局限性内,可以得出GM-10和Dental precale II进行的咬合力测量之间的相关性很低,可能不被认为是可互换的方法。在孤立点接触中测量的最大咬合力是整个弓上分布的咬合力的预测因素。需要进一步的研究来探讨这些发现对临床意义的影响。
{"title":"Correlates and Comparability of Two Devices for Measuring Bite Force in Dentate Health Volunteers","authors":"Murali Srinivasan,&nbsp;Bita Tahoury,&nbsp;Lisa Takeshita,&nbsp;Yasmin Milhomens Moreira,&nbsp;Júlia Siqueira Rodrigues Pavan,&nbsp;Cláudio Rodrigues Leles","doi":"10.1111/joor.13914","DOIUrl":"10.1111/joor.13914","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to correlate the bite/occlusal force measurements obtained through two methods: a hydraulic pressure gauge with a biting transducer (GM-10), and a computer-assisted device that records occlusal force on a pressure-sensitive film (Prescale II).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Healthy, dentate volunteers were recruited. Participants' demographic data included age, sex, number of teeth present, presence of oral pain, history of prior orthodontic treatment and presence of parafunction. Bite/occlusal force measurements were recorded for each participant using the GM-10 and the Prescale II devices. Linear Mixed-effect model regression was performed with the significance set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-six volunteers (women = 25, men = 21; mean-age = 30.9 ± 9.3 years) participated. 54.3% and 34.8% presented with 28 and 29–32 teeth, respectively. 60.9% and 26.1% of the participants reported previous orthodontic treatment and oral parafunction. The overall mean GM-10 measurements recorded were 333.0 ± 192, 276 ± 167, 208 ± 134, 142 ± 103 Newtons, for the 2nd and 1st molars, 2nd and 1st premolars, respectively. GM-10 measurements were associated with the tooth position (<i>p</i> &lt; 0.001) and the number of teeth (<i>p</i> &lt; 0.001). The mean Prescale II measurements obtained with and without filter were 826 ± 594 and 1049 ± 595 Newtons, respectively, which were positively correlated with the occlusal contact area (<i>r</i> = 0.765; <i>p</i> &lt; 0.001) and GM-10 (<i>r</i> = 0.245; <i>p</i> = 0.019). The regression analysis for dependent repeated data confirmed the significant effect of the GM-10 measurements (bite force) and the occlusal contact area on the Prescale II measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Within the limitations of this study, it can be concluded that the correlation between bite force measurements carried out by GM-10 and Dental Prescale II was low and may not be considered interchangeable methods. The maximum bite force measured in isolated point contacts was a predictive factor of the occlusal force distributed over the entire arch. Further studies are warranted to explore this influence in the clinical implications of these findings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"52 3","pages":"384-390"},"PeriodicalIF":3.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reporting of Search Strategy Among Systematic Reviews in Leading Dental Specialty Journals: A Research-On-Research Study. 主要牙科专业期刊中系统综述的检索策略报告:研究对研究的研究
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-26 DOI: 10.1111/joor.13904
Jiayi Li, Xueqian Yu, Lingyue Gao, Lijing Xin, Yan Wang, Feiyang Guo, Fang Hua

Background: Literature searching is one of the main determinants of a systematic review (SR)'s reliability. Thus, adequate reporting of search strategy is essential for the critical appraisal of SRs and evidence-based practice.

Objectives: To assess the reporting quality of search strategy among SRs in leading dental specialty journals, and to identify factors associated with quality of reporting.

Materials and methods: Six leading dental journals with the highest 5-year impact factors in their respective specialty were included. A hand search was undertaken to identify SRs published between 2017 and 2022. Full texts were reviewed by two authors to identify eligible SRs. Reporting quality was assessed and scored using a modified 15-item checklist based on Preferred Reporting Items for Systematic reviews and Meta-Analyses literature search extension (PRISMA-S). Univariable and multivariable linear regression analyses were then performed.

Settings and sample population: A total of 152 reviews were included and assessed.

Results: As for information sources, only 'citation searching' was adequately reported in most reviews 110 (72.4%). Only 23 (15.1%) of the included reviews clearly reported search strategies. Information about peer review was provided in only 10 reviews (6.6%). Only 91 (59.9%) of the included reviews documented the total records clearly. According to multivariable regression analysis, industrial funding (p = 0.012), registration (p = 0.013) and librarian involvement (p = 0.004) were significantly associated with higher reporting quality.

Conclusions: The reporting quality of search strategy among SRs in leading dental specialty journals is suboptimal. Researchers, librarians, reviewers and journal editors in dentistry need to be familiar with the PRISMA-S checklist, and make concerted efforts to improve the reporting of search strategy in SRs.

背景:文献检索是决定系统综述(SR)可靠性的主要因素之一。因此,充分报告检索策略对于系统综述的批判性评价和循证实践至关重要:评估主要牙科专业期刊中系统综述的检索策略报告质量,并确定与报告质量相关的因素:纳入了六种在各自专业领域五年影响因子最高的主要牙科期刊。通过人工检索确定了 2017 年至 2022 年间发表的报告。全文由两位作者审阅,以确定符合条件的报告。根据系统综述和Meta分析首选报告项目文献检索扩展版(PRISMA-S),使用修改后的15项检查表对报告质量进行评估和评分。然后进行单变量和多变量线性回归分析:共纳入并评估了 152 篇综述:结果:在信息来源方面,大多数综述中只有 "引文检索 "得到了充分的报告,共 110 篇(72.4%)。在纳入的综述中,只有 23 篇(15.1%)明确报告了检索策略。只有 10 篇综述(6.6%)提供了同行评审信息。在纳入的综述中,只有 91 篇(59.9%)明确记录了总记录。根据多变量回归分析,工业资助(p = 0.012)、注册(p = 0.013)和图书馆员参与(p = 0.004)与较高的报告质量显著相关:结论:主要牙科专业期刊中的检索策略报告质量不尽如人意。牙科学研究人员、图书馆员、审稿人和期刊编辑需要熟悉PRISMA-S核对表,并共同努力改善SR中检索策略的报告。
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引用次数: 0
Effects of Mandibular Advancement Device on Genioglossus of Rabbits in Obstructive Sleep Apnea Through PINK1/Parkin Pathway 下颌前突矫正器通过 PINK1/Parkin 通路对阻塞性睡眠呼吸暂停家兔舌根的影响
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-26 DOI: 10.1111/joor.13907
Lishuang Ma, Yahui Zhu, Zuo Zhang, Dengying Fan, Haoyan Zhai, Dongna Li, Wenjing Kang, Xing Qiao, Haiyan Lu, Chunyan Liu

Background

Early treatment of mandibular advancement device (MAD) reverses the abnormal changes resulting from obstructive sleep apnoea (OSA), but the underlying mechanism is not clear. We analysed the changes of genioglossus function before and after MAD treatment in OSA rabbits and explored the mechanism of mitochondrial autophagy.

Methods

Eighteen male New Zealand rabbits were randomised into three groups: the control group, Group OSA, and Group MAD. After successful modelling, all animals were induced sleep in supine positions for 4–6 h per day for 8 weeks. Cone beam computed tomography (CBCT) and polysomnography (PSG) were performed to record sleep conditions. The genioglossus contractile force and the levels of LC3-I, LC3-II, Beclin-1, PINK1 and Parkin were detected in three groups. In vitro, C2C12 myoblast cells were cultured under normoxic or hypoxic conditions for 24 h, and then the changes in mitochondrial structure and accumulation of autolysosomes were detected by transmission electron microscopy (TEM).

Results

The contractile tension of the genioglossus in Group OSA was significantly lower than that in the control group. The ratio of LC3II/LC3I and the levels of Beclin-1, PINK1 and Parkin were higher in Group OSA than that in the control group. And the abnormal changes were tended to be normal after MAD treatment. The mitochondrial structure was disrupted, and the number of autolysosomes increased in C2C12 after 24 h of hypoxia.

Conclusions

MAD treatment in male rabbits may decrease the contractile tension of the genioglossus and increase the level of mitochondrial autophagy caused by OSA. And the mechanism of mitochondrial autophagy was mediated by the PINK1/Parkin pathway in male rabbits.

背景:下颌前突装置(MAD)的早期治疗可逆转阻塞性睡眠呼吸暂停(OSA)导致的异常变化,但其潜在机制尚不清楚。我们分析了OSA兔子在MAD治疗前后舌根功能的变化,并探讨了线粒体自噬的机制:18只雄性新西兰兔被随机分为三组:对照组、OSA组和MAD组。在成功建模后,所有动物均以仰卧姿势诱导睡眠,每天 4-6 小时,持续 8 周。进行锥形束计算机断层扫描(CBCT)和多导睡眠监测(PSG)以记录睡眠状况。检测了三个组的膝舌肌收缩力和LC3-I、LC3-II、Beclin-1、PINK1和Parkin的水平。在体外,在常氧或缺氧条件下培养 C2C12 肌母细胞 24 小时,然后用透射电子显微镜(TEM)检测线粒体结构的变化和自溶体的积累:结果:OSA组膝舌肌收缩张力明显低于对照组。OSA组的LC3II/LC3I比值以及Beclin-1、PINK1和Parkin水平均高于对照组。经 MAD 治疗后,异常变化趋于正常。缺氧 24 小时后,C2C12 的线粒体结构被破坏,自溶体数量增加:结论:对雄兔进行 MAD 治疗可降低 OSA 引起的膝舌肌收缩张力,提高线粒体自噬水平。公兔线粒体自噬的机制是由 PINK1/Parkin 通路介导的。
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引用次数: 0
Burning Mouth Syndrome May Essentially Be Related To Psychoneuroimmunology: Mechanism Hypothesis 灼口综合征本质上可能与精神神经免疫学有关:机制假说。
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-26 DOI: 10.1111/joor.13893
Fei Mao, Luyao Cai, Dan Pan, Mei Huang, Qing Wang, Qianming Chen, Ruixue Ai, Yu Zhou

Background

Burning mouth syndrome (BMS) is a chronic intraoral dysesthesia with elusive aetiology, only few studies have been carried out on immune function in BMS patients. We aimed to investigate the role immune function paly in the pathogenesis of BMS by psychoneuroimmunology (PNI).

Method

We recruited 44 BMS patients and 31 controls. We measured the anxiety and depression levels by the Zung’ Self-rating Anxiety Scale (SAS) and Zung’ Self-rating Depression Scale (SDS), respectively. Serological immunity included cellular immunity, humoral immunity and autoantibody. Visual analogue scale (VAS) was used to quantify pain levels. We used the Pearson correlation analysis to analyse the relationship between pain, psychology and immune function.

Results

BMS exhibited higher levels of anxiety and depression (***p < 0.001 for both). In BMS, the CD3+ cells, CD4+ cells were lower (*p = 0.028, 0.046 and 0.033, respectively), IgE and antinuclear antibody (ANA) was higher (*p = 0.035). The average VAS score among BMS was approximately 3.7. Pearson correlation analysis revealed positive correlations between VAS, SAS and SDS; negative correlations between these scores of VAS, SAS, SDS and the levels of CD3+ cells, CD4+ cells, CD8+ cells.

Conclusions

BMS were more painful, anxious, depressive, and immunity dysfunction than controls. We proposed a mechanism hypothesis that the BMS may essentially be an immunological disease.

背景:烧灼口腔综合征(BMS)是一种病因不明的慢性口内感觉障碍,有关BMS患者免疫功能的研究很少。我们旨在通过心理神经免疫学(PNI)研究免疫功能在 BMS 发病机制中的作用:方法:我们招募了 44 名 BMS 患者和 31 名对照者。我们采用 Zung 焦虑自评量表(SAS)和 Zung 抑郁自评量表(SDS)分别测量了患者的焦虑和抑郁水平。血清免疫包括细胞免疫、体液免疫和自身抗体。视觉模拟量表(VAS)用于量化疼痛程度。我们使用皮尔逊相关分析来分析疼痛、心理和免疫功能之间的关系:结果:BMS 的焦虑和抑郁程度较高(***p + 细胞),CD4 + 细胞较低(*p = 0.028、0.046 和 0.033),IgE 和抗核抗体(ANA)较高(*p = 0.035)。BMS 的平均 VAS 评分约为 3.7 分。皮尔逊相关分析显示,VAS、SAS 和 SDS 之间呈正相关;VAS、SAS、SDS 的得分与 CD3+ 细胞、CD4+ 细胞、CD8+ 细胞的水平呈负相关:结论:与对照组相比,BMS 患者更容易出现疼痛、焦虑、抑郁和免疫功能障碍。我们提出了一个机制假设,即 BMS 本质上可能是一种免疫疾病。
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引用次数: 0
Application of Action Observation Therapy in Swallowing Rehabilitation: A Randomised Controlled Study 行动观察疗法在吞咽康复中的应用:随机对照研究
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-26 DOI: 10.1111/joor.13902
Arzucan Toksal Uçar, Bilge Piri Çınar, Banu Alıcıoğlu, Geylan Bostan, Sevil Bilgin

Background

Action Observation Therapy (AOT) has emerged as a potential neurorehabilitation therapy to promote motor control for individuals with neurological dysphagia (ND), facilitating neural plasticity through activation of the mirror nervous system.

Objective

The aim of this study was to investigate the effect of AOT-based dysphagia rehabilitation on suprahyoid (SH) muscle activation, swallowing difficulties, swallowing function, depressive symptom and quality of life in ND patients.

Methods

Thirty-four participants with ND were randomly allocated to the AOT group (n = 17) or control group (n = 17). All participants underwent a 4-week (5 sessions per week) conventional swallowing therapy. The AOT group watched exercise videos before doing these exercises, and the control group performed the same exercises without the videos. Surface electromyographic (sEMG) activation of suprahyoid muscles, Eating Assessment Tool 10 Turkish Version (T-EAT 10) and Swallowing Ability and Function Evaluation (SAFE) for swallowing difficulties and swallowing function, Swallow Quality of Life Questionnaire (SWAL-QOL) and Beck Depression Inventory (BDI) for quality of life and depressive symptom severity were evaluated.

Results

Post-treatment SH amplitude level and T-EAT-10 scores were significantly lower in the AOT group compared to the control group (p = 0.001, p = 0.012). There was a significant improvement in SAFE after treatment in the AOT group (p < 0.05); however, there was no significant difference between the two groups (p > 0.05). Both groups showed similar improvement in quality of life and depression.

Conclusion

This study showed that AOT can be a good option for improving the SH muscle activation and dysphagia difficulties in ND patients.

Trial Registration

ClinicalTrials.gov identifier: NCT05782790

背景:行动观察疗法(AOT)已成为一种潜在的神经康复疗法,可促进神经性吞咽困难(ND)患者的运动控制,通过激活镜像神经系统促进神经可塑性:本研究旨在探讨基于AOT的吞咽困难康复治疗对ND患者舌骨上肌(SH)激活、吞咽困难、吞咽功能、抑郁症状和生活质量的影响:34 名 ND 患者被随机分配到 AOT 组(17 人)或对照组(17 人)。所有参与者均接受为期 4 周(每周 5 次)的常规吞咽治疗。AOT 组在做这些练习之前先观看练习视频,而对照组在不观看视频的情况下做同样的练习。评估内容包括舌骨上肌表面肌电图(sEMG)激活情况、吞咽困难和吞咽功能的进食评估工具 10 土耳其版(T-EAT 10)和吞咽能力与功能评估(SAFE)、吞咽生活质量问卷(SWAL-QOL)以及生活质量和抑郁症状严重程度的贝克抑郁量表(BDI):结果:与对照组相比,治疗后 AOT 组的 SH 振幅水平和 T-EAT-10 评分明显降低(p = 0.001,p = 0.012)。治疗后,AOT 组的 SAFE 有明显改善(P 0.05)。两组在生活质量和抑郁方面的改善情况相似:这项研究表明,AOT可以很好地改善ND患者的SH肌激活和吞咽困难:试验注册:ClinicalTrials.gov identifier:NCT05782790。
{"title":"Application of Action Observation Therapy in Swallowing Rehabilitation: A Randomised Controlled Study","authors":"Arzucan Toksal Uçar,&nbsp;Bilge Piri Çınar,&nbsp;Banu Alıcıoğlu,&nbsp;Geylan Bostan,&nbsp;Sevil Bilgin","doi":"10.1111/joor.13902","DOIUrl":"10.1111/joor.13902","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Action Observation Therapy (AOT) has emerged as a potential neurorehabilitation therapy to promote motor control for individuals with neurological dysphagia (ND), facilitating neural plasticity through activation of the mirror nervous system.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The aim of this study was to investigate the effect of AOT-based dysphagia rehabilitation on suprahyoid (SH) muscle activation, swallowing difficulties, swallowing function, depressive symptom and quality of life in ND patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-four participants with ND were randomly allocated to the AOT group (<i>n</i> = 17) or control group (<i>n</i> = 17). All participants underwent a 4-week (5 sessions per week) conventional swallowing therapy. The AOT group watched exercise videos before doing these exercises, and the control group performed the same exercises without the videos. Surface electromyographic (sEMG) activation of suprahyoid muscles, Eating Assessment Tool 10 Turkish Version (T-EAT 10) and Swallowing Ability and Function Evaluation (SAFE) for swallowing difficulties and swallowing function, Swallow Quality of Life Questionnaire (SWAL-QOL) and Beck Depression Inventory (BDI) for quality of life and depressive symptom severity were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Post-treatment SH amplitude level and T-EAT-10 scores were significantly lower in the AOT group compared to the control group (<i>p</i> = 0.001, <i>p</i> = 0.012). There was a significant improvement in SAFE after treatment in the AOT group (<i>p</i> &lt; 0.05); however, there was no significant difference between the two groups (<i>p</i> &gt; 0.05). Both groups showed similar improvement in quality of life and depression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study showed that AOT can be a good option for improving the SH muscle activation and dysphagia difficulties in ND patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT05782790</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"52 3","pages":"320-331"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Predictive Factors for Swallowing Function Decline in Older Adults With Alzheimer's Disease: A 1-Year Longitudinal Study 老年痴呆症患者吞咽功能下降的预测因素:为期一年的纵向研究
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-26 DOI: 10.1111/joor.13912
Maki Shirobe, Ayako Edahiro, Keiko Motokawa, Shiho Morishita, Yuki Ohara, Yutaka Watanabe, Masanori Iwasaki, Hirohiko Hirano

Background

By 2060, the global burden of dementia, particularly Alzheimer's disease (AD), is expected to increase significantly, necessitating effective palliative care strategies. Dysphagia, a common condition among people with dementia, leads to malnutrition, aspiration pneumonia, and a reduced quality of life.

Objective

This study aimed to identify oral health management factors that could predict a decline in swallowing function in older adults with AD.

Methods

Data from the Akita–Omorimachi study, which included 63 adults diagnosed with AD, were analysed. Swallowing function was assessed using the modified water-swallowing test (MWST) at baseline and after 1 year.

Results

The results indicated that 25.4% of participants exhibited a decline in swallowing function, as indicated by a decrease from the highest MWST score of 5 at baseline to a lower score at follow-up. Poisson regression analysis revealed that refusal of oral care (incidence rate ratio (IRR): 7.28), tongue coating (IRR: 4.21), and unclear articulation of /ka/ (IRR: 5.79) were significant predictors of swallowing function decline. The participants with these indicators had a higher risk of developing dysphagia.

Conclusions

These findings suggest that factors related to specific oral health problems may predict poor swallowing function in older adults with AD. Moreover, implementing targeted oral care interventions, including person-centered care and regular tongue cleaning, may improve the outcomes in this vulnerable population. Despite the limitations of this study, including a small sample size, the results underscore the importance of comprehensive oral health management in preventing dysphagia-related complications.

背景:到 2060 年,全球痴呆症,尤其是阿尔茨海默病(AD)的发病率预计将大幅增加,因此有必要采取有效的姑息治疗策略。吞咽困难是痴呆症患者的常见病,会导致营养不良、吸入性肺炎和生活质量下降:本研究旨在确定可预测老年痴呆症患者吞咽功能下降的口腔健康管理因素:方法:分析了秋田-大森町研究的数据,该研究包括 63 名被诊断为 AD 的成年人。采用改良吞咽水试验(MWST)对基线和一年后的吞咽功能进行评估:结果表明,25.4%的参与者表现出吞咽功能下降,表现为从基线时最高的MWST得分5分下降到随访时的较低分数。泊松回归分析显示,拒绝口腔护理(发生率比 (IRR):7.28)、舌苔(IRR:4.21)和/ka/发音不清(IRR:5.79)是吞咽功能下降的重要预测指标。有这些指标的参与者出现吞咽困难的风险更高:这些研究结果表明,与特定口腔健康问题相关的因素可能预示着患有 AD 的老年人吞咽功能较差。此外,实施有针对性的口腔护理干预措施,包括以人为本的护理和定期清洁舌头,可能会改善这一弱势群体的治疗效果。尽管这项研究存在样本量小等局限性,但研究结果强调了全面口腔健康管理对预防吞咽困难相关并发症的重要性。
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引用次数: 0
Association Between Oral Hypofunction and Maximum Gait Speed in Older Adults: A Cross-Sectional Study 老年人口腔功能减退与最大步速之间的关系:一项横断面研究
IF 3.1 3区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-11-24 DOI: 10.1111/joor.13910
Yukiko Nukaya, Daisuke Matsui, Isao Watanabe, Etsuko Ozaki, Toshiro Yamamoto, Naoyuki Takashima, Narisato Kanamura

Background

Previous studies have reported an association between oral hypofunction and normal gait speed as a marker for physical function; however, the association between maximum gait speed as a more sensitive marker for physical function and poor oral function has not been investigated.

Objectives

To elucidate associations of oral hypofunction, comprising seven elements, with both normal and maximum gait speeds in an older population.

Methods

Participants were recruited in 2018 from a hospital-based health checkup in Kyoto Prefecture. Seven oral function tests (oral hygiene, oral dryness, occlusal force or number of teeth, tongue–lip motor function, tongue pressure, masticatory function and swallowing function) were performed. Oral hypofunction was defined as an abnormality in at least three of these items. Gait speed was measured as normal and maximum gait speeds. The relationship between oral hypofunction and maximum gait speed was analysed using logistic regression.

Results

This study included 198 participants (130 men and 68 women; mean age: 75.0 years). Among them, 152 (76.7%) had oral hypofunction. After adjustment for age, sex and body mass index, oral hypofunction was significantly associated with a low maximum gait speed (odds ratio: 2.75, 95% confidence interval: 1.41–5.37).

Conclusion

Oral hypofunction is associated with maximum gait speed in older people. The prevention of oral hypofunction may help maintain walking speed and promote an increase in healthy life expectancy.

背景:以前的研究报告称,口腔功能低下与作为身体功能标志的正常步速之间存在关联;然而,作为身体功能更敏感标志的最大步速与口腔功能低下之间的关联尚未得到研究:阐明老年人口腔功能低下(包括七个要素)与正常步速和最大步速之间的关联:参与者于 2018 年从京都府的医院健康体检中招募。进行了七项口腔功能测试(口腔卫生、口腔干燥、咬合力或牙齿数量、舌唇运动功能、舌压、咀嚼功能和吞咽功能)。其中至少三项出现异常即为口腔功能低下。步速测量为正常步速和最大步速。采用逻辑回归分析了口腔功能低下与最大步速之间的关系:这项研究包括 198 名参与者(男性 130 人,女性 68 人;平均年龄:75.0 岁)。其中,152 人(76.7%)患有口腔功能低下。在对年龄、性别和体重指数进行调整后,口腔功能减退与最大步速低显著相关(几率比:2.75,95% 置信区间:1.41-5.37):结论:口腔功能减退与老年人的最大步速有关。结论:口腔功能减退与老年人的最大步速有关,预防口腔功能减退有助于保持行走速度,延长健康寿命。
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引用次数: 0
期刊
Journal of oral rehabilitation
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