Rayed Aldausari, Abhishek Kumar, Ayumi Suzuki, Marie Pegelow, Anastasios Grigoriadis
Background
It would be beneficial for clinicians to have more tools to assess the treatment needs of children by measuring bite force, chewing and swallowing function.
Objectives
To evaluate orofacial muscle strength, masticatory and swallowing function in children indicated for orthodontic treatment.
Materials and Methods
Sixty-two volunteers were equally divided into an experimental group (mean age: 14.9 ± 2.8, 15 girls) and a control group (15.2 ± 2.3, 15 girls) based on their orthodontic treatment needs. The orofacial muscle strength was measured by recording the maximum voluntary bite force (MVBF), tongue and cheek pressure. Additionally, the participants also performed food comminution and mixing ability tests to measure their masticatory performance. Swallowing function was assessed with a standardised Test of Masticating and Swallowing Solids (TOMASS).
Results
The results showed significant differences in the MVBF (p = 0.009) between the groups. The results also showed no significant differences in the food comminution test and mixing ability test between the two groups (p = 0.553, p = 0.269, respectively). The results of the TOMASS test showed significant differences in the number of bites to eat the cracker (p = 0.003) but no significant differences in the number of chewing cycles (p = 0.855), the number of swallows (p = 0.149), or duration to eat the cracker (p = 0.275).
Conclusions
Patients indicated for orthodontic treatments show poor orofacial muscle strength in terms of lower MVBF with the age and sex-matched controls.
{"title":"Assessment of Orofacial Muscle Strength, Masticatory and Swallowing Function in Children Indicated for Orthodontic Treatment—A Preliminary Investigation","authors":"Rayed Aldausari, Abhishek Kumar, Ayumi Suzuki, Marie Pegelow, Anastasios Grigoriadis","doi":"10.1111/joor.70091","DOIUrl":"10.1111/joor.70091","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>It would be beneficial for clinicians to have more tools to assess the treatment needs of children by measuring bite force, chewing and swallowing function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate orofacial muscle strength, masticatory and swallowing function in children indicated for orthodontic treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Sixty-two volunteers were equally divided into an experimental group (mean age: 14.9 ± 2.8, 15 girls) and a control group (15.2 ± 2.3, 15 girls) based on their orthodontic treatment needs. The orofacial muscle strength was measured by recording the maximum voluntary bite force (MVBF), tongue and cheek pressure. Additionally, the participants also performed food comminution and mixing ability tests to measure their masticatory performance. Swallowing function was assessed with a standardised Test of Masticating and Swallowing Solids (TOMASS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed significant differences in the MVBF (<i>p</i> = 0.009) between the groups. The results also showed no significant differences in the food comminution test and mixing ability test between the two groups (<i>p</i> = 0.553, <i>p</i> = 0.269, respectively). The results of the TOMASS test showed significant differences in the number of bites to eat the cracker (<i>p</i> = 0.003) but no significant differences in the number of chewing cycles (<i>p</i> = 0.855), the number of swallows (<i>p</i> = 0.149), or duration to eat the cracker (<i>p</i> = 0.275).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients indicated for orthodontic treatments show poor orofacial muscle strength in terms of lower MVBF with the age and sex-matched controls.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 2","pages":"348-356"},"PeriodicalIF":4.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joor.70091","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145345639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The effectiveness of acupuncture combined with manual therapy for the treatment of temporomandibular disorders myalgia (TMDM) has not been studied.
Objectives
To assess the effectiveness of acupuncture combined with manual therapy (MT) for the treatment of TMDM. Furthermore, this study used magnetic resonance imaging (MRI) to observe the influence of acupuncture combined with MT on the thickness, area, and signal intensity ratio (SIR) of the lateral pterygoid muscle (LPM) in patients with TMDM.
Methods
Sixty-five patients with TMDM were randomly divided into M and A + M groups. The M group received manual therapy, and the A + M group received acupuncture combined with manual therapy. All of the above treatments were performed once a day, five times a week for two consecutive weeks. The visual analogue scale (VAS), pressure pain threshold (PPT), painless maximum mouth opening (MMO), jaw functional limitation scale (JFLS) score, and thickness, area, and signal intensity ratio of the LPM were determined. Statistical analyses were performed using SPSS version 23.0. p < 0.05 was considered to be statistically significant.
Results
The VAS and JFLS scores were significantly decreased (p = 0.000, p = 0.000), while the PPT and MMO values were evidently increased after treatment than before treatment in all groups (p = 0.000, p = 0.001). After treatment, compared with the M group, the VAS and JFLS scores were reduced (p = 0.004, p = 0.010), and the PPT and MMO values were increased in the A + M group (p = 0.041, p = 0.006). The overall effective rate in the A + M group was significantly higher than the M group (p = 0.018). Compared with the M group, the area of the upper and lower heads of the LPM increased (p = 0.038, p = 0.040), and the signal intensity ratios decreased in the A + M group (p = 0.032, p = 0.014).
Conclusions
Acupuncture combined with MT was superior to MT alone for the treatment of TMDM. Moreover, acupuncture combined with MT significantly increased the area of the LPM and decreased its SIR.
背景：针刺联合手法治疗颞下颌紊乱性肌痛（TMDM）的疗效尚未见研究。目的：评价针刺结合手法疗法（MT）治疗TMDM的疗效。此外，本研究采用磁共振成像（MRI）观察针刺联合MT对TMDM患者侧翼状肌（LPM）厚度、面积和信号强度比（SIR）的影响。方法：65例TMDM患者随机分为M组和A + M组。M组采用手法治疗，A + M组采用针刺结合手法治疗。以上治疗均为每日1次，每周5次，连续2周。测定视觉模拟评分（VAS）、压痛阈值（PPT）、无痛最大张口度（MMO）、颌功能限制评分（JFLS）及LPM的厚度、面积、信号强度比。采用SPSS 23.0进行统计分析。结果：各组患者治疗后VAS、JFLS评分均较治疗前显著降低（p = 0.000, p = 0.000）， PPT、MMO评分均较治疗前显著升高（p = 0.000, p = 0.001）。治疗后，与M组比较，A + M组VAS、JFLS评分降低（p = 0.004, p = 0.010）， PPT、MMO评分升高（p = 0.041, p = 0.006）。A + M组总有效率显著高于M组（p = 0.018）。与M组比较，A + M组LPM上下头面积增大（p = 0.038, p = 0.040），信号强度比减小（p = 0.032, p = 0.014）。结论：针刺联合MT治疗TMDM优于单纯MT治疗。此外，针刺联合MT显著增加了LPM的面积，降低了其SIR。试验注册：https://www.chictr.org.cn/，标识符：ChiCTR2300072801。
{"title":"Clinical Efficacy of Acupuncture Combined With Manual Therapy in the Treatment of Temporomandibular Disorders Myalgia and Observation of the Changes in the Lateral Pterygoid Muscle: A Randomised Clinical Trial","authors":"Jing Yu, Yuxin Zhang, Kai Yan, Fangli Wang, Jiamei Chu, Yehua Bao, Yuanye Wei, Jianhui Yuan","doi":"10.1111/joor.70090","DOIUrl":"10.1111/joor.70090","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The effectiveness of acupuncture combined with manual therapy for the treatment of temporomandibular disorders myalgia (TMDM) has not been studied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the effectiveness of acupuncture combined with manual therapy (MT) for the treatment of TMDM. Furthermore, this study used magnetic resonance imaging (MRI) to observe the influence of acupuncture combined with MT on the thickness, area, and signal intensity ratio (SIR) of the lateral pterygoid muscle (LPM) in patients with TMDM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sixty-five patients with TMDM were randomly divided into M and A + M groups. The M group received manual therapy, and the A + M group received acupuncture combined with manual therapy. All of the above treatments were performed once a day, five times a week for two consecutive weeks. The visual analogue scale (VAS), pressure pain threshold (PPT), painless maximum mouth opening (MMO), jaw functional limitation scale (JFLS) score, and thickness, area, and signal intensity ratio of the LPM were determined. Statistical analyses were performed using SPSS version 23.0. <i>p</i> < 0.05 was considered to be statistically significant.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The VAS and JFLS scores were significantly decreased (<i>p</i> = 0.000, <i>p</i> = 0.000), while the PPT and MMO values were evidently increased after treatment than before treatment in all groups (<i>p</i> = 0.000, <i>p</i> = 0.001). After treatment, compared with the M group, the VAS and JFLS scores were reduced (<i>p</i> = 0.004, <i>p</i> = 0.010), and the PPT and MMO values were increased in the A + M group (<i>p</i> = 0.041, <i>p</i> = 0.006). The overall effective rate in the A + M group was significantly higher than the M group (<i>p</i> = 0.018). Compared with the M group, the area of the upper and lower heads of the LPM increased (<i>p</i> = 0.038, <i>p</i> = 0.040), and the signal intensity ratios decreased in the A + M group (<i>p</i> = 0.032, <i>p</i> = 0.014).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Acupuncture combined with MT was superior to MT alone for the treatment of TMDM. Moreover, acupuncture combined with MT significantly increased the area of the LPM and decreased its SIR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>https://www.chictr.org.cn/, identifier: ChiCTR2300072801</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 2","pages":"337-347"},"PeriodicalIF":4.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145337193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sex differences in oral health behaviours and function during childhood may affect long-term oral and general health. However, large-scale studies of Japanese children are limited.
Objectives
To clarify sex differences in oral hygiene, masticatory performance, and chewing habits of Japanese schoolchildren.
Methods
This cross-sectional study included 1400 fourth-grade children (686 boys and 714 girls) from public elementary schools in Osaka City. Oral examinations assessed dental plaque, gingival inflammation, and caries experience (DMFT/dmft indices). Masticatory performance was evaluated using a colour-changeable chewing gum test. Chewing and toothbrushing habits were assessed by questionnaires. Logistic regression analyses were conducted to examine associations between sex and oral health outcomes, adjusting for dental development stage and caries indices.
Results
Boys had higher prevalences of dental plaque and gingival inflammation, higher masticatory performance scores, and were more likely to eat fast and eat with the mouth full than girls. On multivariate analyses, boys were more likely to have dental plaque (odds ratio (OR) = 1.31, 95% confidence interval (CI): 1.02–1.68), gingival inflammation (OR = 1.49, 95% CI: 1.04–2.13), eat fast (OR = 3.11, 95% CI: 2.48–3.91), and eat with the mouth full (OR = 2.43, 95% CI: 1.93–3.07), and less likely to have lower masticatory performance (OR = 0.70, 95% CI: 0.55–0.90).
Conclusions
Significant sex differences were observed in oral hygiene, masticatory function, and chewing behaviour of Japanese schoolchildren. These findings highlight the need for sex-specific strategies in oral health, particularly targeting boys with poorer oral hygiene and chewing habits.
{"title":"Sex Differences in Oral Hygiene, Masticatory Performance and Chewing Habits of Japanese Schoolchildren: A Cross-Sectional Study From the Osaka MELON Study","authors":"Takayuki Kosaka, Masatoshi Otsugu, Masayuki Yoshimatsu, Tatsuya Nishimoto, Norimasa Sakanoshita, Yuki Murotani, Risa Hiramatsu, Kazuhiko Nakano, Kazunori Ikebe","doi":"10.1111/joor.70085","DOIUrl":"10.1111/joor.70085","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Sex differences in oral health behaviours and function during childhood may affect long-term oral and general health. However, large-scale studies of Japanese children are limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To clarify sex differences in oral hygiene, masticatory performance, and chewing habits of Japanese schoolchildren.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cross-sectional study included 1400 fourth-grade children (686 boys and 714 girls) from public elementary schools in Osaka City. Oral examinations assessed dental plaque, gingival inflammation, and caries experience (DMFT/dmft indices). Masticatory performance was evaluated using a colour-changeable chewing gum test. Chewing and toothbrushing habits were assessed by questionnaires. Logistic regression analyses were conducted to examine associations between sex and oral health outcomes, adjusting for dental development stage and caries indices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Boys had higher prevalences of dental plaque and gingival inflammation, higher masticatory performance scores, and were more likely to eat fast and eat with the mouth full than girls. On multivariate analyses, boys were more likely to have dental plaque (odds ratio (OR) = 1.31, 95% confidence interval (CI): 1.02–1.68), gingival inflammation (OR = 1.49, 95% CI: 1.04–2.13), eat fast (OR = 3.11, 95% CI: 2.48–3.91), and eat with the mouth full (OR = 2.43, 95% CI: 1.93–3.07), and less likely to have lower masticatory performance (OR = 0.70, 95% CI: 0.55–0.90).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Significant sex differences were observed in oral hygiene, masticatory function, and chewing behaviour of Japanese schoolchildren. These findings highlight the need for sex-specific strategies in oral health, particularly targeting boys with poorer oral hygiene and chewing habits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 2","pages":"321-327"},"PeriodicalIF":4.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joor.70085","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alicia Böthun, Anncristine Fjellman-Wiklund, Fredrik Hellström, Britt-Marie Stålnacke, Birgitta Häggman-Henrikson, Justin Durham, Anna Lövgren
Background
Care should be neutral and equal, but normative beliefs may impact the interaction between patients and healthcare professionals in pain management.
Objectives
To explore how patients with jaw and neck pain perceive pain management and the interaction with healthcare professionals in relation to intersectionality, with a specific focus on gender.
Methods
Recruitment was performed at a specialist dentistry clinic in Sweden. Inclusion criteria were patients aged 18–70 years, reporting jaw and neck pain and understanding the Swedish language. Exclusion criteria were rheumatic disease, temporomandibular joint arthralgia or arthritis. Using purposive sampling, 16 patients (11 women) aged 19–56 were interviewed using individual semi-structured interviews. The analysis was performed using thematic analysis.
Results
The analysis resulted in the theme: ‘Intersectional bias in healthcare – the inequity borne by the patients’, with five subthemes that entailed different types of bias related to the participants' personal characteristics and their interaction with healthcare professionals. Health-related stigmata was one subtheme described among participants, resulting in labelling and burden in the encounter. Other subthemes also described bias in relation to biological differences among pain patients and patients not being taken seriously due to, for example, female gender and younger age. Two subthemes also described bias in relation to the healthcare professionals' gender and age.
Conclusion
Normative beliefs have a negative impact on the interaction between patients and healthcare professionals in pain management. Since patient–provider interaction should be neutral and equal, intersectional bias should be acknowledged to prevent health and care inequalities.
{"title":"Intersectional Bias in Healthcare—The Inequity Borne by the Patients: A Qualitative Study","authors":"Alicia Böthun, Anncristine Fjellman-Wiklund, Fredrik Hellström, Britt-Marie Stålnacke, Birgitta Häggman-Henrikson, Justin Durham, Anna Lövgren","doi":"10.1111/joor.70088","DOIUrl":"10.1111/joor.70088","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Care should be neutral and equal, but normative beliefs may impact the interaction between patients and healthcare professionals in pain management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To explore how patients with jaw and neck pain perceive pain management and the interaction with healthcare professionals in relation to intersectionality, with a specific focus on gender.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Recruitment was performed at a specialist dentistry clinic in Sweden. Inclusion criteria were patients aged 18–70 years, reporting jaw and neck pain and understanding the Swedish language. Exclusion criteria were rheumatic disease, temporomandibular joint arthralgia or arthritis. Using purposive sampling, 16 patients (11 women) aged 19–56 were interviewed using individual semi-structured interviews. The analysis was performed using thematic analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The analysis resulted in the theme: ‘Intersectional bias in healthcare – the inequity borne by the patients’, with five subthemes that entailed different types of bias related to the participants' personal characteristics and their interaction with healthcare professionals. Health-related stigmata was one subtheme described among participants, resulting in labelling and burden in the encounter. Other subthemes also described bias in relation to biological differences among pain patients and patients not being taken seriously due to, for example, female gender and younger age. Two subthemes also described bias in relation to the healthcare professionals' gender and age.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Normative beliefs have a negative impact on the interaction between patients and healthcare professionals in pain management. Since patient–provider interaction should be neutral and equal, intersectional bias should be acknowledged to prevent health and care inequalities.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 2","pages":"328-336"},"PeriodicalIF":4.0,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joor.70088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145301495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The aim of this study was to identify the most important and relevant aspects of functioning related to oral health from the patient's perspective.
Materials and Methods
In this multicenter cross-sectional qualitative study, focus groups and semi-structured interviews were conducted. Adults age 18 years or older with an oral health condition, such as caries, periodontal disease, cancer of the oral cavity or lips, were included. The content of the focus groups and interviews was recorded, transcribed, and analysed using thematic analysis, that is, patterns in the data were identified and broken down into meaningful concepts, which in turn were linked to the most precise categories of the International Classification of Functioning, Disability and Health (ICF). Focus groups and interviews were analysed until saturation was reached.
Results
Statements of 36 participants were included in the analysis. Saturation was reached after analysing five focus groups and 3 interviews, 1213 meaningful concepts were identified and subsequently linked to 150 ICF categories (51 in the Body Functions component, 39 in Activities and Participation, 16 Body Structures, 44 in Environmental Factors) and 102 Personal Factors. Thirty-four concepts were not covered by the ICF and 49 were non-definable concepts. The results of one focus group comprising of young health professionals are displayed separately.
Conclusion
Functioning-based outcomes for persons with an oral health condition were identified in every component of the ICF, indicating that oral health conditions affect different aspects of an individual's everyday life.
{"title":"Identification of Important and Relevant Functioning-Based Outcomes for Persons With an Oral Health Condition From the Patient's Perspective","authors":"C. Lenherr, M. Schimmel, G. Stucki, M. Selb","doi":"10.1111/joor.70078","DOIUrl":"10.1111/joor.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to identify the most important and relevant aspects of functioning related to oral health from the patient's perspective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this multicenter cross-sectional qualitative study, focus groups and semi-structured interviews were conducted. Adults age 18 years or older with an oral health condition, such as caries, periodontal disease, cancer of the oral cavity or lips, were included. The content of the focus groups and interviews was recorded, transcribed, and analysed using thematic analysis, that is, patterns in the data were identified and broken down into meaningful concepts, which in turn were linked to the most precise categories of the International Classification of Functioning, Disability and Health (ICF). Focus groups and interviews were analysed until saturation was reached.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statements of 36 participants were included in the analysis. Saturation was reached after analysing five focus groups and 3 interviews, 1213 meaningful concepts were identified and subsequently linked to 150 ICF categories (51 in the Body Functions component, 39 in Activities and Participation, 16 Body Structures, 44 in Environmental Factors) and 102 Personal Factors. Thirty-four concepts were not covered by the ICF and 49 were non-definable concepts. The results of one focus group comprising of young health professionals are displayed separately.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Functioning-based outcomes for persons with an oral health condition were identified in every component of the ICF, indicating that oral health conditions affect different aspects of an individual's everyday life.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 1","pages":"211-235"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Compromised oral function in patients with stroke hinders the recovery of oral food intake and increases complication risk.
Objective
This study examined the effects of dental treatments on the recovery of oral function associated with dietary intake levels in patients with subacute stroke in convalescent rehabilitation units as a prospective multi-institutional study.
Methods
A total of 237 patients with a recent history of stroke (median age: 75 years, median duration after onset: 26 days) admitted to a rehabilitation unit were assessed for oral function at two time points: within one week after admission (baseline) and before discharge (follow-up). Based on the Functional Oral Intake Scale (FOIS) at the baseline assessment, patients were categorised into the Dysphagia diet (DYS; FOIS ≤ 5) and Normal diet (NML; FOIS > 5) groups. Patients received dental treatments during their stay in addition to routine dysphagia rehabilitation. Differences in oral function between the groups and oral function changes from baseline to follow-up assessment were tested using paired t-tests.
Results
At the baseline assessment, 108 patients (45.5%) received a regular diet, with 179 patients (75.5%) consuming a regular diet by follow-up. Dental treatments performed in 92.4% of all patients decreased the frequency of poorly fitting dentures from 63% to 7%. Maximum tongue pressure and lip-tongue motor function improved significantly in both subject groups (p < 0.02), and were significantly better in patients receiving a regular diet at follow-up assessment (p < 0.05).
Conclusion
These findings highlight the importance of integrating dental treatments into multidisciplinary stroke rehabilitation regimens to optimize dysphagia recovery outcomes.
{"title":"Effects of Dental Treatments on the Recovery of Oral Function Associated With Dietary Intake in Subacute Stroke Patients: A Multi-Center Prospective Study","authors":"Koichiro Matsuo, Tomohisa Ohno, Masako Kishima, Yasuyuki Iwasa, Satoshi Teranaka, Daisuke Kanamori, Rena Hidaka, Junichi Furuya","doi":"10.1111/joor.70082","DOIUrl":"10.1111/joor.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Compromised oral function in patients with stroke hinders the recovery of oral food intake and increases complication risk.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study examined the effects of dental treatments on the recovery of oral function associated with dietary intake levels in patients with subacute stroke in convalescent rehabilitation units as a prospective multi-institutional study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 237 patients with a recent history of stroke (median age: 75 years, median duration after onset: 26 days) admitted to a rehabilitation unit were assessed for oral function at two time points: within one week after admission (baseline) and before discharge (follow-up). Based on the Functional Oral Intake Scale (FOIS) at the baseline assessment, patients were categorised into the Dysphagia diet (DYS; FOIS ≤ 5) and Normal diet (NML; FOIS > 5) groups. Patients received dental treatments during their stay in addition to routine dysphagia rehabilitation. Differences in oral function between the groups and oral function changes from baseline to follow-up assessment were tested using paired <i>t</i>-tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At the baseline assessment, 108 patients (45.5%) received a regular diet, with 179 patients (75.5%) consuming a regular diet by follow-up. Dental treatments performed in 92.4% of all patients decreased the frequency of poorly fitting dentures from 63% to 7%. Maximum tongue pressure and lip-tongue motor function improved significantly in both subject groups (<i>p</i> < 0.02), and were significantly better in patients receiving a regular diet at follow-up assessment (<i>p</i> < 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings highlight the importance of integrating dental treatments into multidisciplinary stroke rehabilitation regimens to optimize dysphagia recovery outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 1","pages":"236-245"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriela Caovilla Felin, Cassiano Mateus Forcelini, Alvaro Della Bona
Background
Temporomandibular disorder (TMD) is a leading cause of orofacial pain, often associated with psychosocial factors that affect quality of life. Although these factors are well documented, the association with pain intensity and jaw function remains understudied.
Objective
This cross-sectional observational study aimed to report the prevalence of emotional factors in patients with TMD and to correlate TMD with psychological factors, pain intensity and functional limitation of the jaw in a sample of the regional population.
Methods
This study used data from a TMD outpatient clinic in South America. Assessments included the DC-TMD, chronic pain scale, GAD-7 (anxiety), PHQ-9 (depression), PHQ-15 (somatic symptoms) and JFLS-8 (jaw function) instruments. Sociodemographic data and the diagnosis of TMD were also reported. Data were statistically analysed using Kolmogorov–Smirnov, two-tailed chi-square, Fisher's exact, Mann–Whitney U, Kruskal–Wallis and Spearman's correlation coefficient tests (α = 0.05).
Results
From 190 patients (mean age 43.5), 78.4% were women, 31.5% had low education and 44.7% had a household income lower than US$ 500. The majority had TMD with pain and joint disorder. The overall chronic pain score was 63, indicating high pain intensity. Psychosocial scores and jaw limitations were mild. Women showed higher pain levels, more functional limitations, and elevated psychosocial scores.
Conclusion
Psychological factors did not differ significantly across TMD subtypes but were highly prevalent, especially in women.
{"title":"Prevalence of Emotional Factors and Pain in Temporomandibular Disorder and Correlation With Different Diagnoses: A Cross-Sectional Study","authors":"Gabriela Caovilla Felin, Cassiano Mateus Forcelini, Alvaro Della Bona","doi":"10.1111/joor.70084","DOIUrl":"10.1111/joor.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Temporomandibular disorder (TMD) is a leading cause of orofacial pain, often associated with psychosocial factors that affect quality of life. Although these factors are well documented, the association with pain intensity and jaw function remains understudied.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This cross-sectional observational study aimed to report the prevalence of emotional factors in patients with TMD and to correlate TMD with psychological factors, pain intensity and functional limitation of the jaw in a sample of the regional population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study used data from a TMD outpatient clinic in South America. Assessments included the DC-TMD, chronic pain scale, GAD-7 (anxiety), PHQ-9 (depression), PHQ-15 (somatic symptoms) and JFLS-8 (jaw function) instruments. Sociodemographic data and the diagnosis of TMD were also reported. Data were statistically analysed using Kolmogorov–Smirnov, two-tailed chi-square, Fisher's exact, Mann–Whitney <i>U</i>, Kruskal–Wallis and Spearman's correlation coefficient tests (<i>α</i> = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 190 patients (mean age 43.5), 78.4% were women, 31.5% had low education and 44.7% had a household income lower than US$ 500. The majority had TMD with pain and joint disorder. The overall chronic pain score was 63, indicating high pain intensity. Psychosocial scores and jaw limitations were mild. Women showed higher pain levels, more functional limitations, and elevated psychosocial scores.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Psychological factors did not differ significantly across TMD subtypes but were highly prevalent, especially in women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 2","pages":"313-320"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/joor.70084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Psychological stress and anxiety are known to influence muscle activity, particularly in the masticatory system. However, the interactive effects of stress, trait anxiety, and gender on objective masseter muscle activity remain poorly understood.
Objectives
This study investigates the association between psychological factors, stress and trait anxiety, as well as gender, and masseter muscle activity during various tasks designed to induce stress or relaxation.
Methods
Thirty-four healthy participants (16 males, 18 females; mean age 28.1 ± 3.1 years) were recruited. Trait anxiety was assessed using the State–Trait Anxiety Inventory (STAI-Y2), and stress levels were measured using a Visual Analog Scale (VAS). Participants completed four randomised tasks (reading, video-watching, math-solving, bead-grabbing) over two experimental days while wearing a wireless EMG logger to record masseter muscle activity. Main outcomes included burst frequency (per hour), wave peak value (%MVC), and integral activity (%MVC·s). Linear mixed models assessed the effects of stress, trait anxiety, and gender. Self-reported oral behaviours (partial Oral Behaviour Checklist; POBC) were also evaluated.
Results
Stress significantly reduced burst frequency (−3.5% per unit; p = 0.016) and wave peak value (−1.9% per unit; p < 0.001) in males but not females. Low-anxiety individuals exhibited increased integral muscle activity with rising stress (+4.8% per unit; p = 0.002), while other groups showed no such trend. Trait anxiety positively correlated with POBC scores (rs = 0.409, p = 0.016).
Conclusions
Masseter muscle activity is differentially modulated by stress, anxiety, and gender. These findings highlight the psychophysiological complexity underlying stress-related oral parafunctional behaviours and support individualised assessment approaches.
背景：已知心理压力和焦虑会影响肌肉活动，特别是咀嚼系统。然而，压力、特质焦虑和性别对客观咬肌活动的相互作用仍然知之甚少。目的：本研究探讨心理因素、压力、特质焦虑、性别与咬肌活动在各种诱导压力或放松任务中的关系。方法：招募34名健康受试者，男16名，女18名，平均年龄28.1±3.1岁。使用状态-特质焦虑量表（STAI-Y2）评估特质焦虑，使用视觉模拟量表（VAS）测量压力水平。在为期两天的实验中，参与者完成了四项随机任务（阅读、观看视频、解题、抓头），同时佩戴了一个无线肌电记录器来记录咬肌的活动。主要结果包括突发频率（每小时）、波峰值（%MVC）和积分活动（%MVC·s）。线性混合模型评估了压力、特质焦虑和性别的影响。自我报告的口腔行为（部分口腔行为检查表；POBC）也被评估。结果：应力显著降低突发频率（-3.5% /单位，p = 0.016）和峰值（-1.9% /单位，p = 0.409, p = 0.016）。结论：咬肌活动受压力、焦虑和性别的差异调节。这些发现强调了与压力相关的口腔功能行为的心理生理复杂性，并支持个性化的评估方法。
{"title":"Stress-, Anxiety-, and Gender-Related Modulation of Masseter Muscle Activity During Wakefulness","authors":"Suvichaya Angkulmahasuk, Akira Nishiyama, Hiroyuki Ishiyama, Kenji Fueki","doi":"10.1111/joor.70077","DOIUrl":"10.1111/joor.70077","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psychological stress and anxiety are known to influence muscle activity, particularly in the masticatory system. However, the interactive effects of stress, trait anxiety, and gender on objective masseter muscle activity remain poorly understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study investigates the association between psychological factors, stress and trait anxiety, as well as gender, and masseter muscle activity during various tasks designed to induce stress or relaxation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-four healthy participants (16 males, 18 females; mean age 28.1 ± 3.1 years) were recruited. Trait anxiety was assessed using the State–Trait Anxiety Inventory (STAI-Y2), and stress levels were measured using a Visual Analog Scale (VAS). Participants completed four randomised tasks (reading, video-watching, math-solving, bead-grabbing) over two experimental days while wearing a wireless EMG logger to record masseter muscle activity. Main outcomes included burst frequency (per hour), wave peak value (%MVC), and integral activity (%MVC·s). Linear mixed models assessed the effects of stress, trait anxiety, and gender. Self-reported oral behaviours (partial Oral Behaviour Checklist; POBC) were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Stress significantly reduced burst frequency (−3.5% per unit; <i>p</i> = 0.016) and wave peak value (−1.9% per unit; <i>p</i> < 0.001) in males but not females. Low-anxiety individuals exhibited increased integral muscle activity with rising stress (+4.8% per unit; <i>p</i> = 0.002), while other groups showed no such trend. Trait anxiety positively correlated with POBC scores (<i>r</i><sub>s</sub> = 0.409, <i>p</i> = 0.016).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Masseter muscle activity is differentially modulated by stress, anxiety, and gender. These findings highlight the psychophysiological complexity underlying stress-related oral parafunctional behaviours and support individualised assessment approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 1","pages":"202-210"},"PeriodicalIF":4.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145292528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The prevalence of oral frailty is high in older adults in China. Older adults in the community may be more likely to ignore the impact of slight changes in oral function in daily life.
Objectives
To analyse the current status and influencing factors of oral frailty.
Methods
In this cross-sectional study, 361 community-dwelling older adults aged ≥ 60 years in four districts of Shijiazhuang were selected as the research objects by convenience sampling method. The number of natural teeth, times of daily teeth brushing, and the Oral Health Assessment Scale for the elderly were used to assess oral frailty.
Results
The prevalence of oral frailty among community-dwelling older adults was 33.4%. Logistic regression analysis showed that older age (70–79 years old compared to 60–69 years old: OR = 2.255, 95% CI: 1.044–4.871; ≥ 80 years old compared to 60–69 years old: OR = 3.644, 95% CI: 1.634–8.123), wearing dentures (OR = 4.625, 95% CI: 2.590–8.259), posterior occlusion pairs < 5 pairs (OR = 8.849, 95% CI: 4.423–17.706), not flossing (OR = 4.870, 95% CI: 1.752–13.540), and not gargling (OR = 2.128, 95% CI: 1.206–3.754) could increase the risk of oral frailty in the community-dwelling older adults. Wearing dentures was a protective factor for oral frailty in older adults with < 20 teeth (OR = 0.704, 95% CI: 0.530–0.935).
Conclusions
The prevalence of oral frailty in older adults in the community is 33.4%, which is at an intermediate level of the reported prevalence in China (17.1%–59.2%), but still higher than that in Japan (20.0%). Older adults who are older, have less than 20 teeth without dentures, have less than five pairs of posterior occlusal pairs, do not use dental floss, and do not gargle are at high risk of oral frailty and should be paid attention to.
{"title":"Analysis of the Current Status and Influencing Factors of Oral Frailty in Community-Dwelling Older Adults","authors":"Mingzhu Lu, Yiming Wei, Ruili Zhang, Huijuan Li","doi":"10.1111/joor.70081","DOIUrl":"10.1111/joor.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The prevalence of oral frailty is high in older adults in China. Older adults in the community may be more likely to ignore the impact of slight changes in oral function in daily life.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To analyse the current status and influencing factors of oral frailty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this cross-sectional study, 361 community-dwelling older adults aged ≥ 60 years in four districts of Shijiazhuang were selected as the research objects by convenience sampling method. The number of natural teeth, times of daily teeth brushing, and the Oral Health Assessment Scale for the elderly were used to assess oral frailty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The prevalence of oral frailty among community-dwelling older adults was 33.4%. Logistic regression analysis showed that older age (70–79 years old compared to 60–69 years old: OR = 2.255, 95% CI: 1.044–4.871; ≥ 80 years old compared to 60–69 years old: OR = 3.644, 95% CI: 1.634–8.123), wearing dentures (OR = 4.625, 95% CI: 2.590–8.259), posterior occlusion pairs < 5 pairs (OR = 8.849, 95% CI: 4.423–17.706), not flossing (OR = 4.870, 95% CI: 1.752–13.540), and not gargling (OR = 2.128, 95% CI: 1.206–3.754) could increase the risk of oral frailty in the community-dwelling older adults. Wearing dentures was a protective factor for oral frailty in older adults with < 20 teeth (OR = 0.704, 95% CI: 0.530–0.935).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The prevalence of oral frailty in older adults in the community is 33.4%, which is at an intermediate level of the reported prevalence in China (17.1%–59.2%), but still higher than that in Japan (20.0%). Older adults who are older, have less than 20 teeth without dentures, have less than five pairs of posterior occlusal pairs, do not use dental floss, and do not gargle are at high risk of oral frailty and should be paid attention to.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 1","pages":"192-201"},"PeriodicalIF":4.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pascal Eber, Yannick M. Sillmann, Ana M. P. Baggio, Philippe Korn, David A. Keith, Shruti Handa, Fernando P. S. Guastaldi
Background
Temporomandibular disorders (TMD) are multifactorial conditions involving biomechanical dysfunction and progressive degeneration of the temporomandibular joint (TMJ) and surrounding tissues. Although affecting up to 36% of the population, their underlying molecular mechanisms remain incompletely understood. Immunohistochemical analysis of synovial biomarkers may help clarify processes involved in tissue degeneration and symptom development.
Objective
This systematic review investigates associations between immunohistochemical biomarkers in synovial tissue and morphological or symptomatic findings in TMD, with a focus on internal derangement and disc displacement.
Methods
A comprehensive literature search was conducted in MEDLINE/PubMed, EMBASE, Web of Science, and selected journals. Studies were screened according to PRISMA guidelines, and methodological quality was assessed using the Newcastle-Ottawa Scale. Due to heterogeneity across studies, a narrative synthesis was performed.
Results
Thirteen studies involving 493 patients (mean age: 42.2 years; 82% women) were included, analyzing 23 different biomarkers. Frequently examined markers included MMPs, COX-2, iNOS, interleukins, and VEGF. Several of these showed statistically significant correlations with histological, radiological, or clinical findings, suggesting roles in joint homeostasis, inflammation, and tissue remodeling associated with TMD.
Conclusion
Based on the reported associations with histological, radiological, and clinical findings, biomarkers were categorised into stage-specific and functional groups, underscoring their relevance for disease stratification and prognosis. By revealing disease-related patterns in progression and severity, synovial biomarkers have the potential to empower our understanding of the underlying mechanisms of TMD and contribute to more precise diagnostic and therapeutic approaches.
背景：颞下颌关节紊乱（TMD）是一种多因素疾病，涉及颞下颌关节（TMJ）及其周围组织的生物力学功能障碍和进行性退行性变。尽管影响到36%的人口，但其潜在的分子机制仍然不完全清楚。滑膜生物标志物的免疫组织化学分析可能有助于阐明涉及组织变性和症状发展的过程。目的：本系统综述探讨滑膜组织免疫组织化学生物标志物与TMD形态学或症状表现之间的关系，重点关注内部紊乱和椎间盘移位。方法：在MEDLINE/PubMed、EMBASE、Web of Science及精选期刊中进行综合文献检索。根据PRISMA指南筛选研究，并使用纽卡斯尔-渥太华量表评估方法学质量。由于研究的异质性，我们进行了叙事综合。结果：纳入了13项研究，涉及493例患者（平均年龄：42.2岁，82%为女性），分析了23种不同的生物标志物。经常检查的标记物包括MMPs、COX-2、iNOS、白细胞介素和VEGF。其中一些与组织学、放射学或临床表现有统计学意义的相关性，提示与TMD相关的关节稳态、炎症和组织重塑的作用。结论：基于已报道的与组织学、放射学和临床表现的关联，生物标志物被分为特定阶段和功能组，强调了它们与疾病分层和预后的相关性。通过揭示疾病进展和严重程度的相关模式，滑膜生物标志物有可能增强我们对TMD潜在机制的理解，并有助于更精确的诊断和治疗方法。
{"title":"Immunohistochemical Profiling in Temporomandibular Disorders: A Systematic Review of Biomarker Patterns in Synovial Tissue","authors":"Pascal Eber, Yannick M. Sillmann, Ana M. P. Baggio, Philippe Korn, David A. Keith, Shruti Handa, Fernando P. S. Guastaldi","doi":"10.1111/joor.70079","DOIUrl":"10.1111/joor.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Temporomandibular disorders (TMD) are multifactorial conditions involving biomechanical dysfunction and progressive degeneration of the temporomandibular joint (TMJ) and surrounding tissues. Although affecting up to 36% of the population, their underlying molecular mechanisms remain incompletely understood. Immunohistochemical analysis of synovial biomarkers may help clarify processes involved in tissue degeneration and symptom development.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This systematic review investigates associations between immunohistochemical biomarkers in synovial tissue and morphological or symptomatic findings in TMD, with a focus on internal derangement and disc displacement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive literature search was conducted in MEDLINE/PubMed, EMBASE, Web of Science, and selected journals. Studies were screened according to PRISMA guidelines, and methodological quality was assessed using the Newcastle-Ottawa Scale. Due to heterogeneity across studies, a narrative synthesis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen studies involving 493 patients (mean age: 42.2 years; 82% women) were included, analyzing 23 different biomarkers. Frequently examined markers included MMPs, COX-2, iNOS, interleukins, and VEGF. Several of these showed statistically significant correlations with histological, radiological, or clinical findings, suggesting roles in joint homeostasis, inflammation, and tissue remodeling associated with TMD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on the reported associations with histological, radiological, and clinical findings, biomarkers were categorised into stage-specific and functional groups, underscoring their relevance for disease stratification and prognosis. By revealing disease-related patterns in progression and severity, synovial biomarkers have the potential to empower our understanding of the underlying mechanisms of TMD and contribute to more precise diagnostic and therapeutic approaches.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16605,"journal":{"name":"Journal of oral rehabilitation","volume":"53 1","pages":"282-306"},"PeriodicalIF":4.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145274809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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