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Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats 对-Cymene对链脲佐菌素诱导的Wistar大鼠糖尿病脂质、肝酶和Akt/Mtor通路的治疗作用
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-04-26 DOI: 10.1155/2022/1015669
Maryam Arabloei Sani, P. Yaghmaei, Z. Hajebrahimi, N. Hayati Roodbari
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong link between hyperglycemia, oxidative stress, inflammation, and the development of diabetes mellitus. PI3K/Akt/mTOR is the main signaling pathway of insulin for controlling lipid and glucose metabolism. P-cymene is an aromatic monoterpene with a widespread range of therapeutic properties including antioxidant and anti-inflammatory activity. In the present study, the antidiabetic effects of p-cymene were investigated. Diabetes was induced using streptozotocin in male Wistar rats. The effects of p-cymene and metformin were studied on levels of glucose (Glu), lipid profile, liver enzymes, oxidative stress, and the expression of Akt, phospho-Akt, and mTOR (mammalian target of rapamycin) proteins, using biochemical, histological, and immunohistochemical analysis. Data have shown that p-cymene can improve serum levels of Glu, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and the expression of mTOR, Akt, and phospho-Akt protein in diabetic animals. These results suggest that p-cymene has hypoglycemia, hypolipidemia, and antioxidant properties. It can regulate Akt/mTOR pathway and reduce hepatic and pancreas injury. It can be suggested for diabetes management alone or simultaneously with metformin.
糖尿病在低收入和中等收入国家是一个严重的公共卫生问题。高血糖、氧化应激、炎症和糖尿病的发展之间有着密切的联系。PI3K/Akt/mTOR是胰岛素控制脂糖代谢的主要信号通路。对伞花烯是一种芳香单萜,具有广泛的抗氧化和抗炎活性。本文研究了对伞花烃的抗糖尿病作用。用链脲佐菌素诱导雄性Wistar大鼠患糖尿病。通过生化、组织学和免疫组织化学分析,研究了对花茉莉烯和二甲双胍对小鼠葡萄糖(Glu)、血脂、肝酶、氧化应激水平以及Akt、磷酸化Akt和mTOR(哺乳动物雷帕霉素靶蛋白)蛋白表达的影响。有数据表明,对花香烃能提高糖尿病动物血清Glu、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)、碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、丙二醛(MDA)水平,以及mTOR、Akt、phospho-Akt蛋白的表达。这些结果表明,对伞花烃具有降血糖、降血脂和抗氧化的特性。可调节Akt/mTOR通路,减轻肝、胰腺损伤。可建议单独或同时与二甲双胍治疗糖尿病。
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引用次数: 7
Association of Anthropometric Indices with Menstrual Abnormality among Nursing Students of Nepal: A Cross-Sectional Study 尼泊尔护生人体测量指标与月经异常的关系:一项横断面研究
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-03-18 DOI: 10.1155/2022/6755436
K. Amgain, Prativa Subedi, G. Yadav, Sujana Neupane, S. Khadka, S. Sapkota
Introduction Obesity has been reported to be linked with menstrual abnormalities including abnormality in cycle length, duration, and period blood loss. However, which anthropometric parameter is a better marker of menstrual abnormality is yet unknown. This study aims to explore the association of BMI, waist-hip ratio (WHR), and waist-height ratio (WHtR) with menstrual abnormalities. Methods This was a cross-sectional study conducted among 240 nursing students on two nursing campuses of Nepal. Demographic and menstrual characteristics related data were collected from the participants via the face-to-face interview technique followed by anthropometric measurements. Binary logistic regression was used to study the association of BMI, WHR, and WHtR with menstrual characteristics. Univariable and multivariable regression models were calculated at 95% confidence interval and a P value of 0.05 using a Statistical Package for Social Sciences, IBM SPSS® v21 (IBM, Armonk, New York). Results Out of 240 participants, 52 participants (21.67%) were underweight (<18.5 kg/m2), and 47 participants (19.58%) were either overweight (≥23 kg/m2) or obese (≥25 kg/m2). Overweight and obese BMI was associated with abnormality in menstrual cycle length (AOR = 4.24; 95% CI = 1.77–10.17), duration of the menstrual period (AOR = 2.52; 95% CI = 1.09–5.81), and periodic menstrual blood loss (AOR = 9.04; 95% CI = 3.55–23.01). Increase in WHtR (>0.5) was associated with abnormal cycle length (AOR = 3.09; 95% CI = 1.09–8.80) and abnormal period duration (AOR = 3.05; 95% CI = 1.10–8.44). An increase in WHR (>0.8) was associated with abnormal cyclical menstrual blood loss (AOR = 4.93; 95% CI = 1.55–15.71). Conclusions Obesity predisposes to menstrual irregularities. BMI is a better predictor of menstrual irregularity as the increase in BMI is associated with abnormality in menstrual cycle length, period duration, and blood loss. Increased WHR was associated with periodic blood loss only. Increased WHtR was associated with abnormal cycle length and period duration, but not menstrual blood loss.
据报道,肥胖与月经异常有关,包括月经周期长度、持续时间和月经失血异常。然而,哪个人体测量参数是一个更好的月经异常的标志尚不清楚。本研究旨在探讨BMI、腰臀比(WHR)、腰高比(WHtR)与月经异常的关系。方法采用横断面研究方法,对尼泊尔两所护理学院的240名护生进行调查。通过面对面访谈技术收集参与者的人口统计学和月经特征相关数据,然后进行人体测量。采用二元logistic回归研究BMI、腰臀比和腰臀比与月经特征的关系。单变量和多变量回归模型采用IBM SPSS®v21 (IBM, Armonk, New York)社会科学统计软件包,以95%置信区间和P值0.05计算。结果240名受试者中,52名(21.67%)体重不足(0.5)与异常周期长度相关(AOR = 3.09;95% CI = 1.09-8.80)和异常期持续时间(AOR = 3.05;95% ci = 1.10-8.44)。WHR升高(>.8)与异常周期性月经失血量相关(AOR = 4.93;95% ci = 1.55-15.71)。结论肥胖易导致月经不规律。BMI是一个更好的预测月经不规律的指标,因为BMI的增加与月经周期长度、经期持续时间和失血异常有关。腰宽比增加仅与周期性失血有关。WHtR增加与异常周期长度和月经持续时间有关,但与月经出血量无关。
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引用次数: 2
Prevalence of Obesity and Overweight among Adults in the Middle East Countries from 2000 to 2020: A Systematic Review and Meta-Analysis. 2000年至2020年中东国家成人肥胖和超重患病率:系统回顾和荟萃分析
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-02-03 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8074837
Hassan Okati-Aliabad, Alireza Ansari-Moghaddam, Shiva Kargar, Neda Jabbari

Background: Obesity has become a significant public health issue worldwide, and it is a major risk factor for many noncommunicable diseases. This systematic review aimed to identify the prevalence of obesity and overweight in the Middle East region and different countries in this region.

Materials and methods: PubMed, Google Scholar, and MEDLINE databases were searched from 2000-2020 to identify relevant studies in the Middle East area. The survey was carried out using combinations of Medical Subject Headings (Mesh) keywords like "body mass index", "obesity", "overweight", "prevalence", "Middle-East", and "Countries in the Middle East area". Analysis of the data was done using STATA-14, and a random-effects model was used to estimate the pooled prevalence.

Results: A total of 101 studies with 698905 participants have been identified that met inclusion criteria for this meta-analysis. The pooled estimates of the prevalence of obesity and overweight in the Middle East area were 21.17 (95% CI: 17.05-26.29) and 33.14 (95% CI: 26.87-40.87), respectively. The findings showed that obesity prevalence increased with age so that the highest prevalence of obesity and overweight was observed in people >40 years old. Obesity prevalence in the Middle East area remained steady between 2000-2006 and 2014-2020 (23%). During these time intervals, the prevalence of overweight decreased from 34.83 (95% CI: 32.40-37.45) to 32.85 (95% CI: 31.39-34.38).

Conclusions: Despite the relative stabilization of the overweight and obesity trend in the Middle East, current interventions to combat the overweight epidemic need to be maintained and strengthened because the prevalence of overweight and obesity in this region is still very high. The prevalence of obesity increases with age so that people over 40 have the highest percentage of obesity and overweight. Therefore, implementing intervention programs to prevent and control obesity and overweight in the Middle East is essential.

背景:肥胖已成为世界范围内一个重要的公共卫生问题,是许多非传染性疾病的主要危险因素。本系统综述旨在确定中东地区和该地区不同国家的肥胖和超重患病率。材料和方法:检索PubMed、Google Scholar和MEDLINE数据库,检索2000-2020年中东地区的相关研究。该调查使用了诸如“身体质量指数”、“肥胖”、“超重”、“患病率”、“中东”和“中东地区国家”等医学主题词(Mesh)的组合进行。使用STATA-14对数据进行分析,并使用随机效应模型来估计合并患病率。结果:共有101项研究698905名受试者符合本荟萃分析的纳入标准。中东地区肥胖和超重患病率的汇总估计分别为21.17 (95% CI: 17.05-26.29)和33.14 (95% CI: 26.87-40.87)。研究结果表明,肥胖患病率随着年龄的增长而增加,其中40岁以上的人群肥胖和超重患病率最高。中东地区的肥胖患病率在2000-2006年和2014-2020年期间保持稳定(23%)。在这些时间间隔内,超重患病率从34.83 (95% CI: 32.40-37.45)降至32.85 (95% CI: 31.39-34.38)。结论:尽管中东地区的超重和肥胖趋势相对稳定,但由于该地区的超重和肥胖患病率仍然很高,因此需要维持和加强目前对抗超重流行病的干预措施。肥胖的患病率随着年龄的增长而增加,因此40岁以上的人肥胖和超重的比例最高。因此,在中东地区实施预防和控制肥胖和超重的干预方案至关重要。
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引用次数: 46
Laparoscopic Banded One Anastomosis Gastric Bypass: A Single-Center Series. 腹腔镜带状胃旁路吻合术:单中心系列。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-01-29 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4942052
Michela Campanelli, Emanuela Bianciardi, Domenico Benavoli, Giulia Bagaglini, Giorgio Lisi, Paolo Gentileschi

Introduction: Laparoscopic one anastomosis gastric bypass (LOAGB) is a relatively new procedure for the treatment of morbid obesity and related comorbidities. On average, this procedure results in good postoperative weight loss with a low complication rate. Recent publications suggest that dumping syndrome and weight regain might be reduced by placing a silicone ring over the gastric pouch during the procedure, so called laparoscopic banded one anastomosis gastric bypass (LBOAGB).

Methods: 86 patients undergoing LBOAGB between 2018 and 2020 were enrolled in this retrospective study. Hospital records were used to assess weight loss, comorbidity resolution, and any complications either in the short or medium term.

Results: 54 Female and 32 male patients were included with a mean age of 43 years (25-64), preoperative body mass index of 42 kg/m2 (35-49), and preoperative weight of 114 kg (86-162). Thirty-four patients presented with type 2 diabetes (39.5%), 42 patients (49%) diagnosed with hypertension, 24 presented with OSAS (28%), and 21 (24%) hypercholesterolaemia patients were included. In total, 36 patients were diagnosed with multiple comorbidities. The operative data showed an average operative time of 48 minutes with 3.4% of patients suffering from early (minor) complications and 2.3% with a late (minor) complication. One patient required reoperation due to intra-abdominal bleeding. The median length of hospital stay was 2.5 days. Median follow-up was 18 months (5-36). In that period, no patient required ring removal or conversion to Roux-en-Y gastric bypass surgery. Food intolerance/vomiting was present in 1 patient (1.1%), bile reflux was present in 1 patient (1.1%), and no stomal ulcers were observed. Mean % excess weight loss at 12 and 24 months was 72% and 80%, respectively. Fifty-two out of 86 patients (60%) had a complete resolution of comorbidities. A CONUT score >2 (mild malnutrition) was found in 40% of patients, while a CONUT score 0-1 was found in 60% of patients.

Conclusion: LBOAGB shows promising results in terms of safety and efficacy in the short term. Further prospective studies will be required to evaluate the consistency of the results in the long term.

腹腔镜一次吻合胃旁路术(LOAGB)是治疗病态肥胖及相关合并症的一种相对较新的手术方法。平均而言,该手术的术后体重减轻效果良好,并发症发生率低。最近的出版物表明,通过在手术过程中在胃袋上放置硅胶环,即所谓的腹腔镜单吻合术胃旁路术(LBOAGB),可以减少倾倒综合征和体重反弹。方法:回顾性研究了2018 - 2020年间86例LBOAGB患者。使用医院记录来评估体重减轻、合并症的解决以及短期或中期的任何并发症。结果:女性54例,男性32例,平均年龄43岁(25-64岁),术前体重指数42 kg/m2(35-49),术前体重114 kg(86-162)。其中34例为2型糖尿病(39.5%),42例为高血压(49%),24例为OSAS(28%), 21例为高胆固醇血症(24%)。总共有36名患者被诊断患有多种合并症。手术资料显示平均手术时间为48分钟,3.4%的患者出现早期(轻微)并发症,2.3%的患者出现晚期(轻微)并发症。1例患者因腹内出血需要再次手术。住院时间中位数为2.5天。中位随访时间为18个月(5-36)。在此期间,没有患者需要取环或转Roux-en-Y胃旁路手术。1例(1.1%)患者出现食物不耐受/呕吐,1例(1.1%)患者出现胆汁反流,未观察到口溃疡。12个月和24个月的平均超重率分别为72%和80%。86例患者中有52例(60%)的合并症得到完全解决。40%的患者的CONUT评分>2(轻度营养不良),60%的患者的CONUT评分为0-1。结论:LBOAGB在短期内具有良好的安全性和有效性。需要进一步的前瞻性研究来评估长期结果的一致性。
{"title":"Laparoscopic Banded One Anastomosis Gastric Bypass: A Single-Center Series.","authors":"Michela Campanelli,&nbsp;Emanuela Bianciardi,&nbsp;Domenico Benavoli,&nbsp;Giulia Bagaglini,&nbsp;Giorgio Lisi,&nbsp;Paolo Gentileschi","doi":"10.1155/2022/4942052","DOIUrl":"https://doi.org/10.1155/2022/4942052","url":null,"abstract":"<p><strong>Introduction: </strong>Laparoscopic one anastomosis gastric bypass (LOAGB) is a relatively new procedure for the treatment of morbid obesity and related comorbidities. On average, this procedure results in good postoperative weight loss with a low complication rate. Recent publications suggest that dumping syndrome and weight regain might be reduced by placing a silicone ring over the gastric pouch during the procedure, so called laparoscopic banded one anastomosis gastric bypass (LBOAGB).</p><p><strong>Methods: </strong>86 patients undergoing LBOAGB between 2018 and 2020 were enrolled in this retrospective study. Hospital records were used to assess weight loss, comorbidity resolution, and any complications either in the short or medium term.</p><p><strong>Results: </strong>54 Female and 32 male patients were included with a mean age of 43 years (25-64), preoperative body mass index of 42 kg/m<sup>2</sup> (35-49), and preoperative weight of 114 kg (86-162). Thirty-four patients presented with type 2 diabetes (39.5%), 42 patients (49%) diagnosed with hypertension, 24 presented with OSAS (28%), and 21 (24%) hypercholesterolaemia patients were included. In total, 36 patients were diagnosed with multiple comorbidities. The operative data showed an average operative time of 48 minutes with 3.4% of patients suffering from early (minor) complications and 2.3% with a late (minor) complication. One patient required reoperation due to intra-abdominal bleeding. The median length of hospital stay was 2.5 days. Median follow-up was 18 months (5-36). In that period, no patient required ring removal or conversion to Roux-en-Y gastric bypass surgery. Food intolerance/vomiting was present in 1 patient (1.1%), bile reflux was present in 1 patient (1.1%), and no stomal ulcers were observed. Mean % excess weight loss at 12 and 24 months was 72% and 80%, respectively. Fifty-two out of 86 patients (60%) had a complete resolution of comorbidities. A CONUT score >2 (mild malnutrition) was found in 40% of patients, while a CONUT score 0-1 was found in 60% of patients.</p><p><strong>Conclusion: </strong>LBOAGB shows promising results in terms of safety and efficacy in the short term. Further prospective studies will be required to evaluate the consistency of the results in the long term.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2022 ","pages":"4942052"},"PeriodicalIF":3.3,"publicationDate":"2022-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39898221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A Case-Control Study of the Association of Leptin Gene Polymorphisms with Plasma Leptin Levels and Obesity in the Kerala Population. 喀拉拉邦人群瘦素基因多态性与血浆瘦素水平和肥胖关系的病例对照研究
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-01-01 DOI: 10.1155/2022/1040650
Sudharmadevi K Manju, Thottathil R Anilkumar, G Vysakh, Balakumaran K Leena, Vijayalekshmi Lekshminarayan, Pradeep G Kumar, Trivikrama K Shenoy

Background: Over the last few years, the importance of leptin in energy metabolism has been extensively studied in both animal models and in humans. Very few results are available on the association between human leptin gene (LEP) variants and obesity traits in India. We designed this study to analyse the polymorphisms in human leptin gene and the association of sequence variants with obesity among the population in Kerala, South India.

Methods: In this case-control design of 148 study participants, data were collected on socioeconomic aspects and anthropometric measurements. Plasma glucose, insulin, leptin, and lipid profile were measured. Genotyping was done by automated DNA sequencing.

Results: The common Single Nucleotide Polymorphism (SNP) of 5'-UTR of LEP - 2548G/A was found to be present in the study population with "A" variant as dominant allele. A novel synonymous mutation Thr5Thr of exon 2 of LEP was identified in heterozygous form in one subject with morbid obesity with hyperleptinemia. A novel missense mutation Phe17Leu was observed in two subjects with obesity in heterozygous condition. A novel missense mutation Lys36Arg in exon 2 of LEP was observed in one subject with abdominal obesity and decreased serum leptin level.

Conclusion: LEP - 2548G/A at 5'-untranslated region was found to be common with the mutant "A" variant in the study population. SNPs of exons in LEP were found to be rare but associated with morbid obesity and altered levels of serum leptin in the study population in Kerala, India.

背景:在过去的几年里,瘦素在能量代谢中的重要性已经在动物模型和人类中得到了广泛的研究。在印度,很少有关于人类瘦素基因(LEP)变异与肥胖特征之间关系的结果。本研究旨在分析印度南部喀拉拉邦人群瘦素基因多态性及其序列变异与肥胖的关系。方法:在148名研究参与者的病例对照设计中,收集了社会经济方面和人体测量的数据。测定血糖、胰岛素、瘦素和血脂。通过自动DNA测序进行基因分型。结果:LEP - 2548G/A的5′- utr共有单核苷酸多态性(SNP)存在于以“A”变异体为优势等位基因的研究人群中。LEP外显子2的一个新的同义突变Thr5Thr在一名患有病态肥胖和高瘦素血症的受试者中以杂合形式被鉴定出来。在2例肥胖患者杂合状态下发现了一种新的错义突变Phe17Leu。在一名腹部肥胖和血清瘦素水平下降的受试者中,观察到LEP外显子2中新错义突变Lys36Arg。结论:LEP - 2548G/A在研究人群的5′-非翻译区与突变体“A”共同存在。在印度喀拉拉邦的研究人群中,LEP外显子的snp被发现是罕见的,但与病态肥胖和血清瘦素水平改变有关。
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引用次数: 2
Retracted: Measures of Adiposity and Risk of Testing Positive for SARS-CoV-2 in the UK Biobank Study. 撤回:英国生物库研究中的肥胖测量和SARS-CoV-2检测阳性的风险。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-01-01 DOI: 10.1155/2022/9848453
Journal Of Obesity

[This retracts the article DOI: 10.1155/2021/8837319.].

[本文撤回文章DOI: 10.1155/2021/8837319.]。
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引用次数: 0
High Prevalence of Prediabetes and Associated Risk Factors in Urban Areas of Pontianak, Indonesia: A Cross-Sectional Study. 印度尼西亚Pontianak城市地区糖尿病前期患病率高及相关危险因素:一项横断面研究。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-01-01 DOI: 10.1155/2022/4851044
Indah Budiastutik, Martha I Kartasurya, Hertanto W Subagio, Bagoes Widjanarko

Uncontrolled prediabetes can develop into Type 2 Diabetes mellitus (T2DM). The incidence of T2DM among adults in Pontianak, Indonesia was reported remarkably high. Therefore, this study aimed to investigate the risk factors for prediabetes in adults living in urban areas of Pontianak, Indonesia. A cross-sectional study was conducted in 5 subdistricts of Pontianak. A total of 506 adults underwent screening to obtain subjects with fasting blood glucose (FBS) of ≤124 mg/dL and aged >30 years. Blood pressure and body mass index (BMI) were measured. Interview using a structured questionnaire were performed to obtain data on predictor variables (age, sex, education, income, health insurance, tobacco use, history of hypertension, gout, high cholesterol level, frequency of exercise per week, and diabetic education). The prevalence of prediabetes among subjects was significantly high (76.4%). Subjects were predominantly above 40 years, female, had low income, low education level, and had health insurance. About a third of the subjects had a history of hypertension, gout, and high cholesterol level, respectively. The exercise frequency was mostly less than 3 times/week, and the BMI was mainly classified as overweight and obese. The result of spearman's rho correlation showed that age (r = 0.146; p=0.022) and BMI (r = 0.130; p=0.041) significantly correlated with prediabetes incidence. Moreover, the chi-square analysis demonstrated that health insurance ownership (OR = 4.473; 95% CI 1.824-10.972; p ≤ 0.001), history of hypertension (OR = 3.096; 95% CI 1.542-6.218; p=0.001), and history of gout (OR = 2.419; 95% CI 1.148-5.099; p=0.018), were associated with prediabetes incidence. For all these significant risk predictors except BMI, the significant associations were found only among female subjects after specific sex analysis. Moreover, multivariate logistic regression showed that health insurance ownerships (OR = 5.956; 95% CI 2.256-15.661; p ≤ 0.001) and history of hypertension (OR = 3.257; 95% CI 1.451-7.311; p=0.004), and systolic blood pressure (OR = 2.141; 95% CI 1.092-4.196; p=0.027) were the risk factors for prediabetes. It is concluded that the prevalence of prediabetes is probably high especially among urban people in Pontianak, Indonesia. Health insurance ownership and hypertension may have an important role in prediabetes management. The risk factors might be different between male and female.

未控制的糖尿病前期可发展为2型糖尿病(T2DM)。据报道,印尼Pontianak的成人2型糖尿病发病率非常高。因此,本研究旨在调查生活在印度尼西亚Pontianak城市地区的成年人前驱糖尿病的危险因素。横断面研究在Pontianak的5个街道进行。共有506名成年人接受了筛查,以获得空腹血糖(FBS)≤124 mg/dL且年龄>30岁的受试者。测量血压和体重指数(BMI)。采用结构化问卷进行访谈,以获得预测变量(年龄、性别、教育程度、收入、健康保险、吸烟、高血压史、痛风史、高胆固醇水平、每周运动频率和糖尿病教育)的数据。受试者中前驱糖尿病的患病率明显较高(76.4%)。研究对象以40岁以上、低收入、低教育水平、有健康保险的女性为主。大约三分之一的受试者分别有高血压、痛风和高胆固醇病史。运动频次多小于3次/周,BMI以超重和肥胖为主。spearman’s rho相关结果显示,年龄(r = 0.146;p=0.022)和BMI (r = 0.130;P =0.041)与糖尿病前期发病率显著相关。此外,卡方分析表明,健康保险所有权(OR = 4.473;95% ci 1.824-10.972;p≤0.001)、高血压史(OR = 3.096;95% ci 1.542-6.218;p=0.001),痛风病史(OR = 2.419;95% ci 1.148-5.099;P =0.018),与糖尿病前期发病率相关。除BMI外,所有这些显著的风险预测因子在特定的性别分析后,仅在女性受试者中发现显著的关联。此外,多元logistic回归显示,健康保险拥有量(OR = 5.956;95% ci 2.256-15.661;p≤0.001)和高血压史(OR = 3.257;95% ci 1.451-7.311;p=0.004),收缩压(OR = 2.141;95% ci 1.092-4.196;P =0.027)为前驱糖尿病的危险因素。结论是,糖尿病前期的患病率可能很高,特别是在印度尼西亚Pontianak的城市人群中。健康保险所有权和高血压可能在糖尿病前期管理中起重要作用。男性和女性的风险因素可能有所不同。
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引用次数: 3
10-Year Changes in Adiposity in Cameroon School-Age Children: Evidence for Increasing Central Adiposity and Higher Adiposity Levels in Tallest-for-Age Children. 喀麦隆学龄儿童肥胖的10年变化:中枢性肥胖增加和年龄最高儿童肥胖水平升高的证据。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-10-15 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6866911
Lifoter K Navti, Brice U S Foudjo

Objective: To examine changes in measures of adiposity and determine the prevalence of excess adiposity in relation to height in school children between 2010 and 2020.

Methods: 5-12-year-old urban school-age children participated in two cross-sectional surveys in 2010 (n = 1274) and 2020 (n = 1550). Standard procedures were used for anthropometric measurements. Changes in BMI, waist circumference (WC), and waist-to-height ratio (WHtR) and the corresponding proportions of children with excess adiposity were analyzed and adjusted for design variables (class and school type) and age. Children were classified according to quartiles of height z-score and prevalence of excess adiposity estimated across each quartile.

Results: There was a 2.4% and 3.3% increase in adjusted mean BMI and WC, respectively, between 2010 and 2020. The prevalence of central overweight/obesity (WC) and WHtR ≥ 0.5 increased by 7.3% (X 2 = 27.151, p < 0.001) and 5.3% (X 2 = 26.117, p < 0.001), respectively, between the two surveys except BMI overweight/obesity. The odds of excess adiposity significantly increased in 2020 for central overweight/obesity (WC) (OR 2.8, 95% CI 2.0-3.6) and WHtR ≥ 0.5 (OR 1.8, 95% CI 1.3-2.4) and not for BMI overweight/obesity (OR 1.3, 95% CI 0.8-1.7). The prevalence of BMI overweight/obesity significantly increased from 33% in 2010 to 51.5% in 2020 in the fourth quartile of height z-score (X 2 = 19.198, p < 0.001). Similarly, the prevalence of central overweight/obesity (WC) significantly increased from 23.5% in 2010 to 42.4% in 2020 in the fourth quartile of height z-score (X 2 = 18.733, p < 0.001).

Conclusion: Central overweight/obesity has increased more than BMI overweight/obesity over the last decade. Children with a higher height-for-age tend to accumulate more adiposity. Objective monitoring of adiposity levels and height of children is needed in future to identify groups for targeted intervention and prevention of chronic diseases.

目的:研究肥胖症测量指标的变化,并确定2010年至2020年间学龄儿童中与身高相关的过度肥胖患病率。方法:2010年(n = 1274)和2020年(n = 1550)对5-12岁城市学龄儿童进行两次横断面调查。人体测量采用标准程序。分析超重儿童BMI、腰围(WC)、腰高比(WHtR)及相应比例的变化,并根据设计变量(班级、学校类型)和年龄进行调整。根据身高z分数的四分位数和每个四分位数估计的过度肥胖患病率对儿童进行分类。结果:2010年至2020年间,调整后的平均BMI和WC分别增加了2.4%和3.3%。除BMI超重/肥胖外,中心性超重/肥胖(WC)患病率和WHtR≥0.5患病率分别增加了7.3% (x2 = 27.151, p < 0.001)和5.3% (x2 = 26.117, p < 0.001)。到2020年,中心性超重/肥胖(WC) (OR 2.8, 95% CI 2.0-3.6)和WHtR≥0.5 (OR 1.8, 95% CI 1.3-2.4)的过度肥胖几率显著增加,而BMI超重/肥胖(OR 1.3, 95% CI 0.8-1.7)没有增加。BMI超重/肥胖患病率从2010年的33%上升到2020年的51.5% (x2 = 19.198, p < 0.001)。同样,在身高z分数的第四个四分位数中,中心超重/肥胖(WC)的患病率从2010年的23.5%显著增加到2020年的42.4% (x2 = 18.733, p < 0.001)。结论:在过去十年中,中枢性超重/肥胖比BMI超重/肥胖增加得更多。身高与年龄之比较高的儿童往往会积累更多的脂肪。未来需要对儿童的肥胖水平和身高进行客观监测,以确定有针对性的干预和预防慢性疾病的人群。
{"title":"10-Year Changes in Adiposity in Cameroon School-Age Children: Evidence for Increasing Central Adiposity and Higher Adiposity Levels in Tallest-for-Age Children.","authors":"Lifoter K Navti,&nbsp;Brice U S Foudjo","doi":"10.1155/2021/6866911","DOIUrl":"https://doi.org/10.1155/2021/6866911","url":null,"abstract":"<p><strong>Objective: </strong>To examine changes in measures of adiposity and determine the prevalence of excess adiposity in relation to height in school children between 2010 and 2020.</p><p><strong>Methods: </strong>5-12-year-old urban school-age children participated in two cross-sectional surveys in 2010 (<i>n</i> = 1274) and 2020 (<i>n</i> = 1550). Standard procedures were used for anthropometric measurements. Changes in BMI, waist circumference (WC), and waist-to-height ratio (WHtR) and the corresponding proportions of children with excess adiposity were analyzed and adjusted for design variables (class and school type) and age. Children were classified according to quartiles of height z-score and prevalence of excess adiposity estimated across each quartile.</p><p><strong>Results: </strong>There was a 2.4% and 3.3% increase in adjusted mean BMI and WC, respectively, between 2010 and 2020. The prevalence of central overweight/obesity (WC) and WHtR ≥ 0.5 increased by 7.3% (<i>X</i> <sup>2</sup> = 27.151, <i>p</i> < 0.001) and 5.3% (<i>X</i> <sup>2</sup> = 26.117, <i>p</i> < 0.001), respectively, between the two surveys except BMI overweight/obesity. The odds of excess adiposity significantly increased in 2020 for central overweight/obesity (WC) (OR 2.8, 95% CI 2.0-3.6) and WHtR ≥ 0.5 (OR 1.8, 95% CI 1.3-2.4) and not for BMI overweight/obesity (OR 1.3, 95% CI 0.8-1.7). The prevalence of BMI overweight/obesity significantly increased from 33% in 2010 to 51.5% in 2020 in the fourth quartile of height z-score (<i>X</i> <sup>2</sup> = 19.198, <i>p</i> < 0.001). Similarly, the prevalence of central overweight/obesity (WC) significantly increased from 23.5% in 2010 to 42.4% in 2020 in the fourth quartile of height z-score (<i>X</i> <sup>2</sup> = 18.733, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Central overweight/obesity has increased more than BMI overweight/obesity over the last decade. Children with a higher height-for-age tend to accumulate more adiposity. Objective monitoring of adiposity levels and height of children is needed in future to identify groups for targeted intervention and prevention of chronic diseases.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2021 ","pages":"6866911"},"PeriodicalIF":3.3,"publicationDate":"2021-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8536440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39552456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Central Obesity and Associated Factors among Adult Patients on Antiretroviral Therapy (ART) in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia. 埃塞俄比亚亚的斯亚贝巴武装部队综合专科医院接受抗逆转录病毒治疗(ART)的成年患者中心性肥胖及其相关因素
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-08-30 eCollection Date: 2021-01-01 DOI: 10.1155/2021/1578653
Adnan Kemal, Mohammed Ahmed, Melese Sinaga Teshome, Kalkidan Hassen Abate

Background: Similar to the general population, the prevalence of central obesity is increasing among HIV-infected persons. There are little data on the burden of abdominal obesity using the waist-to-hip ratio measurement in HIV-infected patients in resource-limited settings, including Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of central obesity among HIV patients taking ART in an armed force comprehensive and specialized hospital, Addis Ababa, Ethiopia.

Methods: A cross-sectional study was conducted from March to April 2018. A systematic sampling method was used to select 353 study participants. Pretested World Health Organization stepwise questionnaire, document review, and anthropometric and biochemical measurements were used to collect data on different variables under the study. The collected data were entered into EpiData version 3 and analyzed by SPSS version 21. An adjusted odds ratio with 95% CI was considered to declare a statistically significant association.

Results: The prevalence of central obesity in this study was 71.7% (95% CI: 67%-76.4%). Besides, the odds of central obesity were associated with being female (AOR: 85.6; 95% CI: 20.09, 364.6), among merchants (AOR: 18.8; 95% CI: 1.39, 255.7), CD4 count <200 cells/mm3 (AOR: 0.03; 95% CI: 0.007, 0.160), among respondents taking AZT + 3TC + EFV-based ART regimen (AOR: 8.73; 95% CI: 1.33, 57.17), ABC + 3TC + ATV/r-based regimen (AOR: 0.18; 95% CI: 0.03, 0.94), increased BMI (AOR: 3.50; 95% CI: 1.36, 3.89), and abnormal blood pressure (AOR: 2.53; 95%: 1.13, 5.67).

Conclusion: It is possible to conclude that central obesity is a huge public health problem among the HIV-infected population in the study area. Being female, increased BMI, low CD4 count, AZT + 3TC + EFV, ABC + 3TC + ATV/r-based regimen, and abnormal blood pressure were associated with central obesity. Therefore, adequate attention must be paid to primary and secondary control of these factors to reduce the prevalence of abdominal obesity among HIV-infected patients.

背景:与普通人群类似,艾滋病毒感染者中中心性肥胖的患病率正在增加。在包括埃塞俄比亚在内的资源有限的环境中,使用腰臀比测量艾滋病毒感染者腹部肥胖负担的数据很少。因此,本研究旨在评估埃塞俄比亚亚的斯亚贝巴一家武装部队综合专科医院接受抗逆转录病毒治疗的HIV患者中中心性肥胖的患病率及其相关因素。方法:2018年3月至4月进行横断面研究。采用系统抽样方法选择353名研究参与者。采用预测试的世界卫生组织逐步问卷、文件审查以及人体测量和生化测量来收集研究中不同变量的数据。将收集到的数据输入EpiData第3版,并通过SPSS第21版进行分析。95%置信区间的调整比值比被认为是一种具有统计学意义的相关性。结果:本研究的中心性肥胖患病率为71.7%(95%CI:67%-76.4%)。此外,中心性肥胖的几率与女性(AOR:85.6;95%CI:2.09364.6)、商人(AOR:18.8;95%CI:1.39/255.7)、CD4计数3(AOR:0.03;95%CI:0.0070.160)、服用AZT的受访者有关 + 3TC + 基于EFV的ART方案(AOR:8.73;95%CI:1.33,57.17),ABC + 3TC + 基于ATV/r的方案(AOR:0.18;95%CI:0.03,0.94)、BMI增加(AOR:3.50;95%CI:1.36,3.89)和血压异常(AOR:2.53;95%CI:1.13,5.67)。女性,BMI增加,CD4计数低,AZT + 3TC + EFV,ABC + 3TC + 基于ATV/r的方案和异常血压与中心性肥胖相关。因此,必须充分重视对这些因素的一级和二级控制,以降低艾滋病毒感染患者腹部肥胖的患病率。
{"title":"Central Obesity and Associated Factors among Adult Patients on Antiretroviral Therapy (ART) in Armed Force Comprehensive and Specialized Hospital, Addis Ababa, Ethiopia.","authors":"Adnan Kemal,&nbsp;Mohammed Ahmed,&nbsp;Melese Sinaga Teshome,&nbsp;Kalkidan Hassen Abate","doi":"10.1155/2021/1578653","DOIUrl":"10.1155/2021/1578653","url":null,"abstract":"<p><strong>Background: </strong>Similar to the general population, the prevalence of central obesity is increasing among HIV-infected persons. There are little data on the burden of abdominal obesity using the waist-to-hip ratio measurement in HIV-infected patients in resource-limited settings, including Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of central obesity among HIV patients taking ART in an armed force comprehensive and specialized hospital, Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A cross-sectional study was conducted from March to April 2018. A systematic sampling method was used to select 353 study participants. Pretested World Health Organization stepwise questionnaire, document review, and anthropometric and biochemical measurements were used to collect data on different variables under the study. The collected data were entered into EpiData version 3 and analyzed by SPSS version 21. An adjusted odds ratio with 95% CI was considered to declare a statistically significant association.</p><p><strong>Results: </strong>The prevalence of central obesity in this study was 71.7% (95% CI: 67%-76.4%). Besides, the odds of central obesity were associated with being female (AOR: 85.6; 95% CI: 20.09, 364.6), among merchants (AOR: 18.8; 95% CI: 1.39, 255.7), CD4 count <200 cells/mm<sup>3</sup> (AOR: 0.03; 95% CI: 0.007, 0.160), among respondents taking AZT + 3TC + EFV-based ART regimen (AOR: 8.73; 95% CI: 1.33, 57.17), ABC + 3TC + ATV/r-based regimen (AOR: 0.18; 95% CI: 0.03, 0.94), increased BMI (AOR: 3.50; 95% CI: 1.36, 3.89), and abnormal blood pressure (AOR: 2.53; 95%: 1.13, 5.67).</p><p><strong>Conclusion: </strong>It is possible to conclude that central obesity is a huge public health problem among the HIV-infected population in the study area. Being female, increased BMI, low CD4 count, AZT + 3TC + EFV, ABC + 3TC + ATV/r-based regimen, and abnormal blood pressure were associated with central obesity. Therefore, adequate attention must be paid to primary and secondary control of these factors to reduce the prevalence of abdominal obesity among HIV-infected patients.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2021 ","pages":"1578653"},"PeriodicalIF":3.3,"publicationDate":"2021-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8423545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10224263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Anthropometric Measurements and Correlations to Glucometabolic and Cardiovascular Risk in Obese Patients Undergoing Gastric Bypass Surgery. 接受胃旁路手术的肥胖患者的人体测量与糖代谢和心血管风险的相关性。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2021-07-16 eCollection Date: 2021-01-01 DOI: 10.1155/2021/6647328
Erica Aldenbäck, Hans-Erik Johansson

Abdominal obesity is associated with hypertension, increased fasting glucose, HbA1c, and cholesterol. Body mass index (BMI) is frequently used to measure and define obesity and as inclusion criteria for bariatric surgery. Sagittal abdominal diameter (SAD) has been suggested to predict the amount of visceral fat, metabolic traits, and cardiometabolic risk superior to BMI. The aim was to test whether SAD has stronger correlations to glucometabolic traits compared to BMI. One hundred and fifty-five (108 women, 47 men) morbidly obese patients undergoing bariatric surgery were evaluated before (baseline), 6 and 12 months after Roux-en-Y gastric bypass (RYGBP). BMI was reduced from 43.7 kg/m2 (baseline) to 31.3 kg/m2 (12 months) and SAD from 32.6 to 23.2 cm (both p<0.001). SAD correlated with CRP (p=0.04), fasting glucose (p=0.008), HbA1c (p=0.016), triglycerides (p=0.017), systolic blood pressure (p=0.032), and vitamin D (p=0.027). BMI correlated with CRP (p=0.006), triglycerides (p=0.016), vitamin D (p=0.002), and magnesium (p=0.037). Despite RYGBP surgery, vitamin D was significantly increased. Liver enzymes were significantly lowered after RYGBP and the change over time in SAD correlated with gamma-glutamyltransferase. SAD was superior to BMI to predict glucose disturbance and dyslipidemia implying increased use of SAD as it is cost effective and simple to perform in the clinic and could be of value when considering patients for bariatric surgery.

腹部肥胖与高血压、空腹血糖、糖化血红蛋白和胆固醇升高有关。身体质量指数(BMI)经常被用来衡量和定义肥胖,并作为减肥手术的纳入标准。矢状腹直径(SAD)被认为比BMI更能预测内脏脂肪的数量、代谢特征和心脏代谢风险。目的是测试与BMI相比,SAD是否与糖代谢特征有更强的相关性。155名(108名女性,47名男性)接受减肥手术的病态肥胖患者在Roux-en-Y胃旁路手术(RYGBP)前(基线)、6个月和12个月进行了评估。BMI从43.7 kg/m2(基线)降至31.3 kg/m2(12个月),SAD从32.6降至23.2 cm(均pp=0.04),空腹血糖(p=0.008)、糖化血红蛋白(p=0.016)、甘油三酯(p=0.017)、收缩压(p=0.032)和维生素D (p=0.027)。BMI与CRP (p=0.006)、甘油三酯(p=0.016)、维生素D (p=0.002)和镁(p=0.037)相关。尽管进行了RYGBP手术,维生素D仍显著增加。RYGBP后肝酶显著降低,SAD随时间的变化与γ -谷氨酰转移酶相关。SAD在预测血糖紊乱和血脂异常方面优于BMI,这意味着SAD的使用增加,因为它在临床中成本有效且操作简单,在考虑患者进行减肥手术时可能有价值。
{"title":"Anthropometric Measurements and Correlations to Glucometabolic and Cardiovascular Risk in Obese Patients Undergoing Gastric Bypass Surgery.","authors":"Erica Aldenbäck,&nbsp;Hans-Erik Johansson","doi":"10.1155/2021/6647328","DOIUrl":"https://doi.org/10.1155/2021/6647328","url":null,"abstract":"<p><p>Abdominal obesity is associated with hypertension, increased fasting glucose, HbA1c, and cholesterol. Body mass index (BMI) is frequently used to measure and define obesity and as inclusion criteria for bariatric surgery. Sagittal abdominal diameter (SAD) has been suggested to predict the amount of visceral fat, metabolic traits, and cardiometabolic risk superior to BMI. The aim was to test whether SAD has stronger correlations to glucometabolic traits compared to BMI. One hundred and fifty-five (108 women, 47 men) morbidly obese patients undergoing bariatric surgery were evaluated before (baseline), 6 and 12 months after Roux-en-Y gastric bypass (RYGBP). BMI was reduced from 43.7 kg/m2 (baseline) to 31.3 kg/m2 (12 months) and SAD from 32.6 to 23.2 cm (both <i>p</i><0.001). SAD correlated with CRP (<i>p</i>=0.04), fasting glucose (<i>p</i>=0.008), HbA1c (<i>p</i>=0.016), triglycerides (<i>p</i>=0.017), systolic blood pressure (<i>p</i>=0.032), and vitamin D (<i>p</i>=0.027). BMI correlated with CRP (<i>p</i>=0.006), triglycerides (<i>p</i>=0.016), vitamin D (<i>p</i>=0.002), and magnesium (<i>p</i>=0.037). Despite RYGBP surgery, vitamin D was significantly increased. Liver enzymes were significantly lowered after RYGBP and the change over time in SAD correlated with gamma-glutamyltransferase. SAD was superior to BMI to predict glucose disturbance and dyslipidemia implying increased use of SAD as it is cost effective and simple to perform in the clinic and could be of value when considering patients for bariatric surgery.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2021 ","pages":"6647328"},"PeriodicalIF":3.3,"publicationDate":"2021-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39265510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
期刊
Journal of Obesity
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