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A Propensity Score Cohort Study on the Long-Term Safety and Efficacy of Sleeve Gastrectomy in Patients Older Than Age 60. 60岁以上患者袖式胃切除术长期安全性和有效性的倾向评分队列研究。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-07-31 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8783260
Judith Molero, Romina Olbeyra, Josep Vidal, Ferran Torres, Silvia Cañizares, Alba Andreu, Ainitze Ibarzabal, Amanda Jiménez, Ana de Hollanda, Violeta Moizé, Lilliam Flores

Background: Bariatric surgery (BS) in older obese subjects (>60 years of age) has risen in the past decade and will continue to rise in the coming years due to ageing of the population.

Aim: To evaluate the short- (12 months) and long-term (60 months) results of laparoscopic sleeve gastroscopy (LSG) in patients older than age 60.

Methods: We performed a retrospective review of patients prospectively included in a database from January 2007 to December 2013. All patients >60 [older group (OG)] who had undergone LSG were included. The control group (CG) included patients aged 50 to 59 years who had undergone LSG during the same period.

Results: 116 (8.4 % of total surgery) and 145 patients were included in the OG and CG, respectively. BS in patients >60 years increased from 2.4% in 2003 to 14% in the last 2 years of the study. After inverse probability of treatment weighting (IPTW) analysis, all absolute standardized differences were <0.15. A 60-month follow-up was attained in 90% of patients in the OG and 74% in the CG. There were no significant differences in postoperative complications between the two groups. At 12 and 60 months after LSG, both groups achieved a similar body mass index. There was no statistical difference in the percentage of resolution of type 2 diabetes, hypertension, dyslipidemia, and SAHS between the two groups. In both groups, all the nutritional parameters evaluated remained within the normal range throughout the study.

Conclusions: LSG provides acceptable outcomes and is safe in older adults indicating that age should not be a limitation to perform BS in this population.

背景:老年肥胖患者(>60岁)的减肥手术(BS)在过去十年中有所上升,并且由于人口老龄化,在未来几年将继续上升。目的:评价60岁以上患者行腹腔镜袖胃镜检查(LSG)的短期(12个月)和长期(60个月)效果。方法:我们对2007年1月至2013年12月前瞻性纳入数据库的患者进行回顾性分析。所有>60岁且行LSG的患者[老年组(OG)]均纳入。对照组(CG)包括同期行LSG的50 ~ 59岁患者。结果:OG组116例(占总手术量8.4%),CG组145例。60岁以上患者BS发生率从2003年的2.4%上升到研究的最后2年的14%。在治疗加权逆概率(IPTW)分析后,所有绝对标准化差异均为:结论:LSG提供了可接受的结果,并且在老年人中是安全的,这表明年龄不应成为在该人群中实施BS的限制。
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引用次数: 3
The Burden of Overweight and Obesity among Long-Distance Truckers in Ethiopia. 埃塞俄比亚长途卡车司机超重和肥胖的负担。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-07-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4242789
Tewodros Yosef, Biruk Bogale, Alemnew Destaw, Angesom Weldu

Background: Abnormal body mass index (BMI ≥ 25 kg/m2) has become a major global public health problem which is rising at a faster rate in urban areas of low- and middle-income countries. In Ethiopia, the prevalence gradually increases. Long-distance truckers are at a high risk of developing overweight or obesity due to the sedentary nature of their job. Despite these populations at a high risk of developing overweight/obesity such as drivers elsewhere, pieces of data that showed the prevalence and contributing factors of overweight and obesity among long-distance truckers in Ethiopia are not yet available.

Objective: To assess the prevalence and contributing factors of overweight and obesity among long-distance truckers in Ethiopia.

Methods: A cross-sectional study was conducted among 400 systematically selected truckers at Modjo dry port in Ethiopia from February to March, 2018. Data were collected through face-to-face interviews using a structured questionnaire. The final results were presented in tables and numerical summary measures such as mean and standard deviation (SD).

Results: Of the 400 truckers interviewed, the prevalence of overweight and obesity was 56.5%, 95% CI (51.6%-61.4%). The study also found that a monthly income ≥220 USD (AOR = 1.83, 95% CI (1.05-3.18)), having 3 or more family sizes (AOR = 2.24, 95% CI (1.15-4.36)), less than 6 hours of sleep at night (AOR = 3.34, 95% CI (1.99-5.78)), driving for 9 or more hours daily (AOR = 2.29, 95% CI (1.09-4.81)), and a truck driving experience of 10 or more years (AOR = 2.13, 95% CI (1.29-4.18)) were significantly associated with overweight and obesity.

Conclusion: The prevalence of overweight and obesity was substantially high. The study also found that sociodemographic and occupational factors are mainly associated with overweight and obesity. Therefore, a health education program should be designed for awareness creation on the importance of reducing a sedentary lifestyle, consuming healthy foods or drinks, and having regular physical exercise to mitigate the problem.

背景:异常体重指数(BMI≥25 kg/m2)已成为一个主要的全球公共卫生问题,在低收入和中等收入国家的城市地区以更快的速度上升。在埃塞俄比亚,流行率逐渐上升。由于长途卡车司机的工作是久坐不动的,因此他们患超重或肥胖的风险很高。尽管这些人群与其他地方的司机一样有超重/肥胖的高风险,但显示埃塞俄比亚长途卡车司机中超重和肥胖的患病率及其影响因素的数据尚未获得。目的:了解埃塞俄比亚长途卡车司机超重和肥胖的患病率及其影响因素。方法:对2018年2 - 3月在埃塞俄比亚Modjo陆运港系统选择的400名卡车司机进行横断面研究。数据是通过面对面访谈收集的,使用结构化问卷。最终结果以表格和数值汇总指标如平均值和标准差(SD)的形式呈现。结果:400名受访卡车司机中,超重和肥胖患病率为56.5%,95% CI(51.6% ~ 61.4%)。研究还发现,月收入≥220美元(AOR = 1.83, 95% CI(1.05-3.18))、有3个或更多家庭成员(AOR = 2.24, 95% CI(1.15-4.36))、夜间睡眠时间不足6小时(AOR = 3.34, 95% CI(1.99-5.78))、每天开车9小时或以上(AOR = 2.29, 95% CI(1.09-4.81))、卡车驾驶经验10年或以上(AOR = 2.13, 95% CI(1.29-4.18))与超重和肥胖显著相关。结论:超重和肥胖的患病率相当高。该研究还发现,社会人口和职业因素与超重和肥胖主要相关。因此,应该设计一个健康教育计划,以提高人们对减少久坐不动的生活方式、食用健康食品或饮料以及定期进行体育锻炼的重要性的认识,以减轻这个问题。
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引用次数: 8
Development and Cross-Validation of Anthropometric Predictive Equations to Estimate Total Body Fat Percentage in Adult Women in Sri Lanka. 用于估算斯里兰卡成年女性总体脂率的人体测量预测方程的开发和交叉验证。
IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-07-15 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2087346
Nirmala Rathnayake, Gayani Alwis, Janaka Lenora, Sarath Lekamwasam

Attempts have been made to estimate body fat using anthropometry, and most of them are country-specific. This study was designed to develop and cross-validate anthropometric predictive equations to estimate the total body fat percentage (TBFP) of Sri Lankan adult women. A cross-sectional study was conducted in Galle, Sri Lanka, with two groups: Group A (group for equation development) and Group B (cross-validation group) (n = 175 each) of randomly selected healthy adult women aged 30-60 years. TBFP (%) was quantified with total body DXA (TBFPDXA). Height (m), weight (kg), and skinfold thickness (SFT, mm) at six sites and circumferences (cm) at five sites were measured. In the first step, four anthropometric equations were developed based on the data obtained from multiple regression analyses (TBFPDXA = dependent variable and anthropometric measurements and age = independent variables) with Group A. They were developed on the basis of circumferences (TBFP1), SFTs (TBFP2), circumferences and SFTs (TBFP3), and highly significant circumferences and SFTs (r ≥ 0.6) (TBFP4). In the second step, the newly developed equations were cross-validated using Group B. Three equations (TBFP1, TBFP2, and TBFP4) showed the agreement with cross-validation criteria. There were no differences between TBFPDXA and TBFP estimated by these equations (p > 0.05). They showed higher measurement concordance with TBFPDXA; correlation between measured TBFP with DXA and estimated with TBFP1, TBFP2, and TBFP4, respectively, was 0.80 (R 2 = 0.65, SEE = 3.10), 0.83 (R 2 = 0.69, SEE = 2.93), and 0.84 (R 2 = 0.72, SEE = 2.78). Three anthropometric measurements based on predictive equations were developed and cross-validated to satisfactorily estimate the TBFP in adult women.

人们曾尝试使用人体测量法来估算体脂,但大多数方法都是针对特定国家的。本研究旨在开发和交叉验证人体测量预测方程,以估算斯里兰卡成年女性的总体脂率(TBFP)。这项横断面研究在斯里兰卡加勒进行,分为两组:A 组(方程开发组)和 B 组(交叉验证组)(n = 175)均为随机选取的 30-60 岁健康成年女性。TBFP(%)通过全身 DXA(TBFPDXA)进行量化。测量了身高(米)、体重(公斤)、六个部位的皮褶厚度(SFT,毫米)和五个部位的周长(厘米)。第一步,根据对 A 组进行的多元回归分析(TBFPDXA = 因变量,人体测量数据和年龄 = 自变量)所获得的数据,建立了四个人体测量方程,分别基于周长(TBFP1)、皮褶厚度(SFT)(TBFP2)、周长和皮褶厚度(SFT)(TBFP3)以及高度显著的周长和皮褶厚度(r ≥ 0.6)(TBFP4)。第二步,使用 B 组对新开发的方程进行交叉验证。有三个方程(TBFP1、TBFP2 和 TBFP4)显示与交叉验证标准一致。这些方程估计的 TBFPDXA 和 TBFP 之间没有差异(P > 0.05)。它们与 TBFPDXA 的测量一致性更高;用 DXA 测量的 TBFP 与用 TBFP1、TBFP2 和 TBFP4 估算的 TBFP 之间的相关性分别为 0.80(R 2 = 0.65,SEE = 3.10)、0.83(R 2 = 0.69,SEE = 2.93)和 0.84(R 2 = 0.72,SEE = 2.78)。根据预测方程开发并交叉验证了三种人体测量方法,可以令人满意地估计成年女性的 TBFP。
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引用次数: 0
Hyperglycaemia in Pregnancy and Anthropometric Parameters in the Offspring at 10 Years: A Community-Based Retrospective Cohort Study in Sri Lanka. 妊娠期高血糖和10年后后代的人体测量参数:斯里兰卡社区回顾性队列研究
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-06-25 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2735148
Himali P Herath, Rasika P Herath, Rajitha Wickremasinghe

Background: Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero.

Objective: The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age.

Methods: A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded.

Results: 159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, p < 0.001), waist circumference (63 cm vs 59.3 cm, p < 0.001), and triceps skinfold thickness (13.7 mm vs 11.2 mm, p < 0.001) were significantly higher in the exposed group. Offspring of women with HIP were more likely to be overweight (aOR = 2.6, 95% CI 1.4-4.9) and have abdominal obesity (aOR = 2.7, 95% CI 1.1-6.5) and high TSFT (aOR = 2.2, 95% CI 1.06-4.7) at 10-11 years than children who were not exposed after adjusting for maternal BMI, maternal age at delivery, and birth order.

Conclusions: Intrauterine exposure to HIP is a significant determinant of overweight, high TSFT, and abdominal obesity in the offspring.

背景:对健康和疾病的发育起源的研究强调了宫内高血糖的可能作用,增加了后代未来肥胖、糖尿病和心血管疾病的风险。在南亚人群中,由于母体在子宫内患有糖尿病而导致儿童肥胖的风险估计证据有限。目的:本研究的目的是确定妊娠期高血糖(HIP)与后代10-11岁时人体测量参数之间的关系。方法:在斯里兰卡科伦坡地区进行以社区为基础的回顾性队列研究。在第一阶段,确定了2005年出生的儿童,并评估了产前记录的可得性。在第二阶段,根据产前记录和预先确定的标准确定参与者的暴露状况。在第三阶段,测量符合条件的参与者的身高、体重、腰围和三头肌皮褶厚度(TSFT),以确定结果状态。通过访谈母亲收集背景特征。记录24小时饮食回忆和3天饮食日记。结果:159名患有HIP的母亲的孩子(暴露)和253名没有HIP的母亲的孩子(未暴露)参与了研究。暴露组和未暴露组的平均年龄(SD)分别为10.9(0.3)和10.8(0.3)岁。暴露组的中位BMI (17.6 vs 16.1, p < 0.001)、腰围(63 cm vs 59.3 cm, p < 0.001)和肱三头肌皮褶厚度(13.7 mm vs 11.2 mm, p < 0.001)显著高于暴露组。在调整了母亲的BMI、分娩年龄和出生顺序后,HIP妇女的后代在10-11岁时比未暴露的儿童更容易超重(aOR = 2.6, 95% CI 1.4-4.9)、腹部肥胖(aOR = 2.7, 95% CI 1.1-6.5)和高TSFT (aOR = 2.2, 95% CI 1.06-4.7)。结论:宫内暴露于HIP是后代超重、高TSFT和腹部肥胖的重要决定因素。
{"title":"Hyperglycaemia in Pregnancy and Anthropometric Parameters in the Offspring at 10 Years: A Community-Based Retrospective Cohort Study in Sri Lanka.","authors":"Himali P Herath,&nbsp;Rasika P Herath,&nbsp;Rajitha Wickremasinghe","doi":"10.1155/2020/2735148","DOIUrl":"https://doi.org/10.1155/2020/2735148","url":null,"abstract":"<p><strong>Background: </strong>Studies of developmental origins of health and disease have highlighted the possible role of intrauterine hyperglycaemia, increasing the future risk of obesity, diabetes, and cardiovascular diseases in the offspring. There is limited evidence from South Asian populations for risk estimates for childhood obesity that are attributable to maternal diabetes in utero.</p><p><strong>Objective: </strong>The aim of this study was to determine the association between hyperglycaemia in pregnancy (HIP) and anthropometric parameters in the offspring at 10-11 years of age.</p><p><strong>Methods: </strong>A community-based retrospective cohort study was conducted in Colombo district, Sri Lanka. In the first stage, children born in 2005 were identified, and the availability of antenatal records was assessed. In the second stage, the exposure status of participants was ascertained based on antenatal records and predefined criteria. In the third stage, height, weight, waist circumference, and triceps skinfold thickness (TSFT) of eligible participants were measured to ascertain the outcome status. Background characteristics were collected by interviewing mothers. A 24-hour dietary recall and a 3-day diet diary were recorded.</p><p><strong>Results: </strong>159 children of mothers with HIP (exposed) and 253 children of mothers with no HIP (nonexposed) participated. Mean ages (SD) of exposed and unexposed groups were 10.9 (0.3) and 10.8 (0.3) years, respectively. The median BMI (17.6 vs 16.1, <i>p</i> < 0.001), waist circumference (63 cm vs 59.3 cm, <i>p</i> < 0.001), and triceps skinfold thickness (13.7 mm vs 11.2 mm, <i>p</i> < 0.001) were significantly higher in the exposed group. Offspring of women with HIP were more likely to be overweight (aOR = 2.6, 95% CI 1.4-4.9) and have abdominal obesity (aOR = 2.7, 95% CI 1.1-6.5) and high TSFT (aOR = 2.2, 95% CI 1.06-4.7) at 10-11 years than children who were not exposed after adjusting for maternal BMI, maternal age at delivery, and birth order.</p><p><strong>Conclusions: </strong>Intrauterine exposure to HIP is a significant determinant of overweight, high TSFT, and abdominal obesity in the offspring.</p>","PeriodicalId":16628,"journal":{"name":"Journal of Obesity","volume":"2020 ","pages":"2735148"},"PeriodicalIF":3.3,"publicationDate":"2020-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/2735148","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38157512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Developing a Socioculturally Nuanced Systems Model of Childhood Obesity in Manhattan's Chinese American Community via Group Model Building. 基于群体模型构建的曼哈顿美籍华人社区儿童肥胖社会文化差异系统模型
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-06-19 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4819143
Ewelina Swierad, Terry T-K Huang, Ellis Ballard, Karen Flórez, Sheng Li

The purpose of this study was to develop a qualitative and socioculturally tailored systems model of childhood obesity in the Chinese American community in Manhattan's Chinatown. We utilized group model building (GMB) methodology as a form of participatory systems modeling. The study was conducted in Manhattan's Chinatown community. We recruited 16 Chinese American adults from the community. GMB workshops engendered a causal loop diagram (CLD), the visualization of a complex systems model illustrating the structures, feedbacks, and interdependencies among socioculturally specific pathways underlying childhood obesity, in Manhattan's Chinatown community. The analysis of CLD revealed that participants considered the following factors to influence childhood obesity: (1) traditional social norms affecting body image, how children are raised, parental pressure to study, and trust in health of traditional foods; (2) grandparents' responsibility for children; (3) limited time availability of parents at home; and (4) a significant amount of children's time spent indoors. GMB represents a novel method to understand the complexity of childhood obesity in culturally specific populations and contexts. The study identified sociocultural subsystems that may underlie the development and perpetuation of childhood obesity among Chinese American children. Insights from the study can be useful in the design of future empirical studies and interventions.

本研究的目的是开发一个定性和社会文化量身定制的系统模型在曼哈顿唐人街的华裔美国社区儿童肥胖。我们利用群体模型构建(GMB)方法作为参与式系统建模的一种形式。这项研究是在曼哈顿的唐人街社区进行的。我们从社区中招募了16名美籍华人。GMB研讨会产生了一个因果循环图(CLD),这是一个复杂系统模型的可视化,说明了曼哈顿唐人街社区儿童肥胖的社会文化特定途径之间的结构、反馈和相互依赖性。CLD分析显示,参与者认为影响儿童肥胖的因素有:(1)影响身体形象的传统社会规范、儿童的成长方式、父母的学习压力和对传统食品健康的信任;(二)祖父母对子女的责任;(3)家长在家的时间有限;(4)儿童在室内度过的时间相当长。GMB代表了一种新的方法来理解儿童肥胖在文化特定人群和背景下的复杂性。该研究确定了可能导致华裔美国儿童肥胖发展和持续存在的社会文化子系统。该研究的见解可用于设计未来的实证研究和干预措施。
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引用次数: 12
Explaining the Inverse Association between Altitude and Obesity. 解释海拔高度和肥胖之间的负相关关系。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-05-31 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1946723
Ray M Merrill

Purpose: To better understand the inverse association between altitude and adult obesity.

Methods: An ecological study design was used, involving 3,108 counties in the contiguous United States. Data were from several national sources, and assessment involved various statistical techniques, including multiple regression analysis.

Results: Living in counties at higher altitude is associated with lower adult obesity. Compared with counties <500 meters, the percent of adult obesity decreases by 5.18% at 500-999 meters, 9.69% at 1,000-1,499 meters, 16.77% at 1,500-1,999 meters, 24.14% at 2,000-2,499 meters, and 35.28% at ≥2,500 meters. After adjusting for physical inactivity, smoking, and other variables, corresponding decreases in adult obesity with higher altitude groupings are 3.87%, 5.64%, 8.03%, 11.41%, and 17.54%, respectively. Various mechanisms are presented as possible explanations for the association between higher altitude and lower obesity. In addition, altitude may indirectly influence adult obesity, primarily through its relationship with physical inactivity and smoking. In an adjusted regression model, adult obesity was most strongly associated with physical inactivity followed by adult smoking and then altitude. Together they explain 39.04% of the variation in adult obesity. After accounting for these variables, sunlight, precipitation, ambient air temperature, education, income, food insecurity, limited access to healthy foods, race, sex, and rural living explain an additional 4.68% of the variation in adult obesity.

Conclusions: The inverse association between altitude and adult obesity remains significant after adjustment for several variables.

目的:更好地了解海拔与成人肥胖的负相关关系。方法:采用生态学研究设计,涉及美国连片的3108个县。数据来自几个国家来源,评估涉及各种统计技术,包括多元回归分析。结果:居住在高海拔地区的成人肥胖率较低。结论:经若干变量调整后,海拔高度与成人肥胖呈显著负相关。
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引用次数: 13
Epidemiology, Predisposing Factors, Biomarkers, and Prevention Mechanism of Obesity: A Systematic Review. 肥胖症的流行病学、诱发因素、生物标志物和预防机制:系统回顾。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-05-31 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6134362
Melese Linger Endalifer, Gedefaw Diress

Background. Globally, obesity is becoming a public health problem in the general population. Various determinants were reported by different scholars even though there are inconsistencies. Different biomarkers of obesity were identified for the prediction of obesity. Even though researchers speculate the factors, biomarkers, consequences, and prevention mechanisms, there is a lack of aggregate and purified data in the area of obesity. Summary. In this review, the epidemiology, predisposing factors, biomarkers, consequences, and prevention approaches of obesity were reviewed. Key Messages. The epidemiology of obesity increased in low-, middle-, and high-income countries. Even if the factors vary across regions and socioeconomic levels, sociodemographic, behavioral, and genetic factors were prominent for the development of obesity. There are a lot of biomarkers for obesity, of which microRNA, adipocytes, oxidative stress, blood cell profile, nutrients, and microbiota were promising biomarkers for determination of occurrence of obesity. Since the consequences of obesity are vast and interrelated, multidimensional prevention strategy is mandatory in all nations.

背景。在全球范围内,肥胖正成为普通人群的一个公共健康问题。不同学者对肥胖的各种决定因素进行了研究,但研究结果并不一致。不同的肥胖生物标志物被确定用于预测肥胖。尽管研究人员对肥胖的因素、生物标志物、后果和预防机制进行了推测,但在肥胖领域仍缺乏综合和纯化的数据。总结。本综述对肥胖症的流行病学、诱发因素、生物标志物、后果和预防方法进行了综述。关键信息。肥胖症的流行病学在低收入、中等收入和高收入国家都有所增加。即使不同地区和社会经济水平的因素各不相同,但社会人口、行为和遗传因素在肥胖症的发生中占突出地位。肥胖症的生物标志物很多,其中微小核糖核酸、脂肪细胞、氧化应激、血细胞谱、营养素和微生物群是确定肥胖症发生的有希望的生物标志物。由于肥胖症的影响范围广泛且相互关联,因此各国都必须采取多维度的预防策略。
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引用次数: 0
Banded Sleeve Gastrectomy Improves Weight Loss Compared to Nonbanded Sleeve: Midterm Results from a Prospective Randomized Study. 与非袖带胃切除术相比,袖带胃切除术可改善体重减轻:一项前瞻性随机研究的中期结果。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-05-28 eCollection Date: 2020-01-01 DOI: 10.1155/2020/9792518
Paolo Gentileschi, Emanuela Bianciardi, Leandro Siragusa, Valeria Tognoni, Domenico Benavoli, Stefano D'Ugo

Background: Weight regain after laparoscopic sleeve gastrectomy (LSG) is nowadays a growing concern. Sleeve dilatation and loss of food restriction is considered the main mechanism. The placement of a silicon ring around the gastric tube seems to give benefits in the short term. We report the results of a randomized study comparing LSG and laparoscopic banded sleeve gastrectomy (LBSG) over a 4-year follow-up.

Objectives: To evaluate the efficacy of banded sleeve gastrectomy compared to standard sleeve in the midterm.

Methods: Between 01/2014 and 01/2015, we randomly assigned 50 patients to receive one of the two procedures. Patients' management was exactly the same, apart from the band placement. We analyzed differences in weight loss, operative time, complication rate, and mortality, with a median follow-up of 4 years.

Results: Twenty five patients were assigned to receive LSG (Group A) and 25 LBSG (Group B). The mean preoperative BMI (body mass index) was 47.3 ± 6.58 kg/m2 and 45.95 ± 5.85 kg/m2, respectively. There was no significant difference in the operative time. No intraoperative or postoperative complications occurred. At 12-month follow-up, the mean BMI was 29.72 ± 4.40 kg/m2 in Group A and 27.42 ± 4.47 kg/m2 in Group B (p=0.186). After a median follow-up of 4 years, the mean BMI in Group B was significantly lower than Group A (24.10 ± 4.52 kg/m2 vs 28.80 ± 4.62 kg/m2; p=0.00199).

Conclusions: LBSG is a safe procedure, with no impact on postoperative complications. The banded sleeve showed a significant greater weight loss in the midterm follow-up. Considering the issue of weight regain observed after LSG, the placement of a perigastric ring during the first procedure may be a strategy to improve the results. This trial is registered with NCT04228185.

背景:腹腔镜袖胃切除术(LSG)后体重恢复是目前越来越关注的问题。套筒膨胀和失去食物限制被认为是主要机制。在胃管周围放置一个硅环似乎在短期内有好处。我们报告了一项随机研究的结果,比较了LSG和腹腔镜带状袖胃切除术(LBSG)超过4年的随访。目的:评价带状袖套胃切除术与标准袖套胃切除术的中期疗效。方法:在2014年1月至2015年1月期间,我们随机选择50例患者接受两种方法中的一种。患者的处理是完全相同的,除了带放置。我们分析了体重减轻、手术时间、并发症发生率和死亡率的差异,中位随访时间为4年。结果:25例患者接受LBSG治疗(A组),25例患者接受LBSG治疗(B组),术前平均BMI(体质量指数)分别为47.3±6.58 kg/m2和45.95±5.85 kg/m2。两组手术时间差异无统计学意义。无术中、术后并发症发生。随访12个月时,A组平均BMI为29.72±4.40 kg/m2, B组平均BMI为27.42±4.47 kg/m2 (p=0.186)。中位随访4年后,B组平均BMI显著低于a组(24.10±4.52 kg/m2 vs 28.80±4.62 kg/m2;p = 0.00199)。结论:LBSG是一种安全的手术,对术后并发症无影响。在中期随访中,带状套筒组显示出更显著的体重减轻。考虑到LSG术后体重反弹的问题,在第一次手术中放置腹周环可能是改善结果的一种策略。该试验注册号为NCT04228185。
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引用次数: 18
Predictors of One-Year Change in How Youth Perceive Their Weight. 年轻人如何看待自己的体重一年变化的预测因素。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-05-15 eCollection Date: 2020-01-01 DOI: 10.1155/2020/7396948
Karen A Patte, Wei Qian, Scott T Leatherdale

Overall, perceptions of being at "about the right weight" appear advantageous for youth physical and mental health, regardless of BMI classification, whereas perceptions at either extreme (overweight or underweight) may negatively impact health behaviours and mental health. Instead of considering weight misperceptions as problematic, some researchers have proposed that underestimations of weight status may offer resiliency among individuals with overweight or obesity. Promoting "about right" WPs and preventing change to overweight or underweight perceptions may offer an effective public health strategy for supporting youth health over time. However, limited prospective evidence exists on factors that shape perceptions of weight status over time. The current study examined modifiable predictors of one-year change in weight perception among youths. We used 2-year linked data of 18,112 grade 9-12 students from Year 3 (Y3:2014-2015) and Year 4 (Y4:2015-2016) of the COMPASS study. Generalized Estimating Equation models tested screen use, physical activity, and bullying victimization as predictors of change from perceptions of "about the right weight" to "overweight" or "underweight" perceptions, adjusting for Y3 covariates (body mass index, ethnicity, and grade) and school cluster. Results support the value of team sports among females and resistance exercise among males as protective against changes to overweight or underweight perceptions over one year. Also, various forms of bullying victimization predicted overweight perceptions in males and females. Watching TV/movies or messaging/texting for over 2 hours/day was associated with overweight and underweight perceptions, respectively, in females only. Playing video/computer games for over 2 hours/day was associated with overweight perceptions in males and underweight perceptions in females. Findings support the potential of bullying prevention, limiting certain screen use, and supporting engagement in team sports for females and resistance exercise for males as strategies to maintain perceptions of being at "about the right weight."

总体而言,无论BMI分类如何,“体重适中”的观念似乎有利于青少年的身心健康,而极端的观念(超重或体重不足)可能对健康行为和心理健康产生负面影响。一些研究人员提出,低估体重状况可能会给超重或肥胖的人带来弹性,而不是将体重误解视为问题。促进“大致正确”的饮食习惯和防止改变对超重或体重不足的看法,可能是一项有效的公共卫生战略,可长期支持青年健康。然而,随着时间的推移,影响人们对体重状况看法的因素的前瞻性证据有限。目前的研究调查了一年内青少年体重认知变化的可变预测因素。我们使用了COMPASS研究的3年级(3年级:2014-2015)和4年级(4年级:2015-2016)的18112名9-12年级学生的2年关联数据。广义估计方程模型测试了屏幕使用、身体活动和欺凌受害作为从“大约正确体重”感知到“超重”或“体重不足”感知变化的预测因子,调整了三年级协变量(体重指数、种族和年级)和学校群。研究结果支持了团队运动在女性中的价值,以及抵抗运动在男性中对一年内超重或体重过轻观念的改变的保护作用。此外,各种形式的欺凌受害者预示着男性和女性的超重认知。每天看电视/电影或发短信/短信超过2小时分别与超重和体重不足的感觉有关,这仅在女性中存在。每天玩2小时以上的视频/电脑游戏与男性超重和女性体重不足的感觉有关。研究结果支持预防欺凌的潜力,限制某些屏幕使用,支持女性参与团队运动和男性抵抗运动,作为保持“适当体重”的策略。
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引用次数: 8
Weight Change and Its Association with Cardiometabolic Risk Markers in Overweight and Obese Women. 超重和肥胖妇女体重变化及其与心脏代谢危险标志物的关系
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2020-04-13 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3198326
Liyana Ahmad Zamri, Geeta Appannah, Siti Yazmin Zahari Sham, Fazliana Mansor, Rashidah Ambak, Noor Safiza Mohd Nor, Tahir Aris

Objectives: To examine the association of weight loss magnitude with changes in cardiometabolic risk markers in overweight and obese women from low socioeconomic areas engaged in a lifestyle intervention.

Methods: Analyses were performed on 243 women (mean body mass index 31.27 ± 4.14 kg/m2) who completed a 12-month lifestyle intervention in low socioeconomic communities in Klang Valley, Malaysia. Analysis of covariance (ANCOVA) was used to compare changes of cardiometabolic risk factors across weight change categories (2% gain, ±2% maintain, >2 to <5% loss, and 5 to 20% loss) within intervention and control group.

Results: A graded association for changes in waist circumference, fasting insulin, and total cholesterol (p=0.002, for all variables) across the weight change categories were observed within the intervention group at six months postintervention. Participants who lost 5 to 20% of weight had the greatest improvements in those risk markers (-5.67 cm CI: -7.98 to -3.36, -4.27 μU/mL CI: -7.35, -1.19, and -0.59 mmol/L CI: -.99, -0.19, respectively) compared to those who did not. Those who lost >2% to <5% weight reduced more waist circumference (-4.24 cm CI: -5.44 to -3.04) and fasting insulin (-0.36 μU/mL CI: -1.95 to 1.24) than those who maintained or gained weight. No significant association was detected in changes of risk markers across the weight change categories within the control group except for waist circumference and adiponectin.

Conclusion: Weight loss of >2 to <5% obtained through lifestyle intervention may represent a reasonable initial weight loss target for women in the low socioeconomic community as it led to improvements in selected risk markers, particularly of diabetes risk.

目的:研究来自低社会经济地区的超重和肥胖妇女进行生活方式干预时,体重减轻程度与心脏代谢危险标志物变化的关系。方法:对马来西亚巴生谷低社会经济社区完成12个月生活方式干预的243名妇女(平均体重指数31.27±4.14 kg/m2)进行分析。采用协方差分析(ANCOVA)比较不同体重变化类别(增加2%,维持±2%,>2)中心脏代谢危险因素的变化。结果:干预组在干预后6个月观察到不同体重变化类别中腰围、空腹胰岛素和总胆固醇的变化呈分级关联(所有变量p=0.002)。体重减轻5%至20%的参与者在这些风险指标上有最大的改善(-5.67 cm CI: -7.98至-3.36,-4.27 μU/mL CI: -7.35, -1.19和-0.59 mmol/L CI: -)。99,分别为-0.19)。体重减轻>2% (μU/mL CI: -1.95 ~ 1.24)者比体重维持或增加者多。在对照组中,除了腰围和脂联素外,在体重变化类别的风险指标变化中没有发现显著的关联。结论:体重减轻>2 ~ 2
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引用次数: 4
期刊
Journal of Obesity
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