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Gender Difference in Food Choice and Eating Practice and Their Association with Health among Students of Kathmandu, Nepal. 尼泊尔加德满都学生食物选择和饮食习惯的性别差异及其与健康的关系。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-08-25 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2340809
Maginsh Dahal, Alisha Basnet, Sudip Khanal, Kushalata Baral, Smriti Dhakal
Background Our eating practice is generally based on the food we choose to eat. The selection of unhealthy food, high cost of healthy food items, and easy availability of fast food may have negative impact on our health and eating behaviour. This study aims to access the gender difference in food choice and eating practice and their association with health among students in Kathmandu, Nepal. Methods A cross-sectional descriptive study was conducted among 385 randomly selected undergraduate BBA (Bachelor in Business Administration) students of Tribhuvan University in Kathmandu by using semistructured self-administered questionnaire. The questionnaire included sociodemographic characters, health status, behaviour factors, eating practice, and food choice which were measured using Food Choice Questionnaire (FCQ). The data was analysed in SPSS. Frequency, percentage, mean, and standard deviation were calculated, and chi-square test and logistic regression were used to measure the association between two variables. Results The study is comprised of 50.4% female and 49.6% male with mean ages of 20.04 and 20.75, respectively. A gender difference was observed in food choice but no gender difference was observed in eating practice. There was no significant association of food choice and eating practice with health. However, food choice and eating practice showed an association with the current living status of the respondents. Sensory appeal and health were the most important food choice motives among males and females, respectively. Conclusion The study concluded that no gender difference was observed in food choice. However, gender difference was observed in eating practice. There was no association of food choice and eating practice with health.
背景:我们的饮食习惯通常是基于我们选择吃的食物。不健康食品的选择、健康食品的高成本以及快餐的易得性可能对我们的健康和饮食行为产生负面影响。本研究旨在了解尼泊尔加德满都学生在食物选择和饮食习惯方面的性别差异及其与健康的关系。方法:采用半结构式自评问卷对加德满都特里布万大学工商管理专业385名本科生进行横断面描述性研究。问卷内容包括社会人口学特征、健康状况、行为因素、饮食习惯和食物选择,采用食物选择问卷(FCQ)进行测量。用SPSS软件对数据进行分析。计算频率、百分比、均值和标准差,并采用卡方检验和logistic回归来衡量两变量之间的相关性。结果:女性占50.4%,男性占49.6%,平均年龄分别为20.04岁和20.75岁。在食物选择上存在性别差异,但在饮食习惯上没有性别差异。食物选择和饮食习惯与健康之间没有明显的联系。然而,食物选择和饮食习惯显示出与受访者当前生活状况的关联。感官吸引力和健康分别是男性和女性最重要的食物选择动机。结论:研究得出的结论是,在食物选择上没有性别差异。然而,在饮食习惯上却存在性别差异。食物选择和饮食习惯与健康没有关联。
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引用次数: 1
Influence of Overweight and Obesity on Morbidity and Mortality among Hospitalized Patients in Sri Lanka: A Single-Center Analysis. 超重和肥胖对斯里兰卡住院患者发病率和死亡率的影响:一项单中心分析
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-08-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/9172365
M D S A Dilrukshi, V Thotamuna, D J Senarath Yapa, L De Silva, P Ranasinghe, P Katulanda

Background: Current evidence regarding the association between overweight and obesity and in-hospital morbidity and mortality is inconsistent and South Asian populations are underrepresented.

Methods: Data relevant to anthropometry, hospital outcomes, complications, and medical diagnoses of all acute medical admissions to the National Hospital of Sri Lanka were collected over a period of 3 months. Analysis was performed with WHO international (ICs) and Asian obesity cut-offs (ACs).

Results: Sample size was 2,128 (median age: 57 years [IQR: 42, 67], males: 49.7%). High prevalence of overweight (23.5%), generalized obesity (10.4%), central obesity (28.5%), and underweight (15.4%) was observed (ICs). Patients with either generalized or central obesity had significantly higher in-hospital mortality (4.8% versus 2.5%, p = 0.031) and acute kidney injury (AKI) (3.9% versus 1.2%) (p = 0.001) compared to normal weight. With ACs, overweight and obesity prevalence increased, without any significant increment in morbidity and mortality, but median length of hospital stay was significantly reduced in patients with generalized obesity compared to normal (3 [IQR: 2, 5] versus 4 [IQR: 2, 6], p = 0.014). Infections (44.4%) and cardiovascular diseases (CVDs) (25.9%) were the most common causes of admission. Overweight and generalized obesity or central obesity were associated with increased prevalence of acute CVDs and CVD risk factors and lower prevalence of acute infections, whilst underweight showed an inverse association.

Conclusion: A double burden of malnutrition and diseases were noted among hospital admissions, with obesity being a risk factor for in-hospital all-cause mortality and AKI. Overweight and obesity were associated with increased CVDs and reduced infections. Larger prospective studies are required to characterize these associations among South Asians.

背景:目前关于超重和肥胖与院内发病率和死亡率之间关系的证据不一致,南亚人口代表性不足。方法:收集斯里兰卡国立医院3个月内所有急性住院患者的人体测量、医院预后、并发症和医学诊断相关数据。采用世卫组织国际(ic)和亚洲肥胖临界值(ACs)进行分析。结果:样本量为2128例(中位年龄:57岁[IQR: 42,67],男性:49.7%)。超重(23.5%)、全身性肥胖(10.4%)、中心性肥胖(28.5%)和体重不足(15.4%)的患病率较高(ICs)。与体重正常的患者相比,全身性肥胖或中心性肥胖患者的住院死亡率(4.8%对2.5%,p = 0.031)和急性肾损伤(AKI)(3.9%对1.2%)(p = 0.001)显著更高。随着ACs的发生,超重和肥胖患病率增加,发病率和死亡率没有显著增加,但与正常患者相比,全面性肥胖患者的中位住院时间显著缩短(3 [IQR: 2,5]对4 [IQR: 2,6], p = 0.014)。感染(44.4%)和心血管疾病(25.9%)是最常见的入院原因。超重、全身性肥胖或中心性肥胖与急性心血管疾病患病率和心血管疾病危险因素的增加以及急性感染患病率的降低相关,而体重过轻则呈负相关。结论:住院患者中存在营养不良和疾病的双重负担,肥胖是院内全因死亡率和AKI的危险因素。超重和肥胖与心血管疾病增加和感染减少有关。需要更大规模的前瞻性研究来描述南亚人之间的这些关联。
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引用次数: 1
Overweight and Its Associated Factors among Women of Reproductive Age in Dire Dawa, Eastern Ethiopia, 2021: Community-Based Cross-Sectional Study. 2021年埃塞俄比亚东部迪勒达瓦育龄妇女超重及其相关因素:基于社区的横断面研究
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-08-16 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7268573
Ismael Omer, Tariku Derese, Yitagesu Sintayehu

Background: Overweight in women of reproductive age is a major public health concern in developing countries because of overconsumption of low-quality food. Currently, being overweight is a major health concern worldwide. It exposes humans to various health problems. In Ethiopia, despite the trend indicated increasing in overweight, priority is given for undernutrition. In Dire Dawa, there is scarce evidence regarding reproductive age overweight. Therefore, this study is designed to assess the prevalence of overweight and its associated factors among women of reproductive age in eastern Ethiopia.

Methods: A community-based cross-sectional study was conducted from May 15 to June 15, 2021, in Dire Dawa, Eastern Ethiopia; a multi-stage systematic sampling technique was used to select 559 women aged 15-49 years. Data were collected through face-to-face interviews using a structured pretested questionnaire. Ninety-five percent CI was used to identify the factors associated with overweight while controlling for all possible confounders using multivariable logistic regression. Statistical significance was set at a P-value of 0.05.

Results: The results of this study revealed that the prevalence of overweight was 63.1% (95% CI: 59.0, 67.2). Overweight was significantly associated with weekly discretionary calories (AOR = 3.964, 95% CI (1.131, 13.894)), contraceptive use (AOR = 2.838, 95% CI (1.443, 5.580)), and monthly family income (AOR = 3.916, 95% CI (1.352, 11.340)).

Conclusion: Overweight among women of reproductive age was high in Dire Dawa city. Discretionary calories per week, family monthly income, and contraceptive use were significantly associated with overweight. Developing and implementing community-based culturally sensitive, feasible, and potentially high-impact intervention to address the modifiable risk factors among women of reproductive age is critical.

背景:由于过度食用低质量食品,育龄妇女超重是发展中国家一个主要的公共卫生问题。目前,超重是世界范围内的一个主要健康问题。它使人类面临各种健康问题。在埃塞俄比亚,尽管超重的趋势有所增加,但仍优先考虑营养不足问题。在迪勒达瓦,几乎没有关于育龄超重的证据。因此,本研究旨在评估埃塞俄比亚东部育龄妇女中超重的患病率及其相关因素。方法:于2021年5月15日至6月15日在埃塞俄比亚东部的Dire Dawa进行了一项基于社区的横断面研究;采用多阶段系统抽样方法,抽取年龄在15 ~ 49岁的女性559名。数据通过面对面访谈收集,使用结构化的预测问卷。95% CI用于确定与超重相关的因素,同时使用多变量逻辑回归控制所有可能的混杂因素。p值为0.05,差异有统计学意义。结果:本研究结果显示,超重患病率为63.1% (95% CI: 59.0, 67.2)。超重与每周可自由支配热量(AOR = 3.964, 95% CI(1.131, 13.894))、避孕措施使用(AOR = 2.838, 95% CI(1.443, 5.580))和家庭月收入(AOR = 3.916, 95% CI(1.352, 11.340))显著相关。结论:迪勒达瓦市育龄妇女体重偏高。每周可自由支配的卡路里、家庭月收入和避孕措施的使用与超重显著相关。制定和实施以社区为基础的具有文化敏感性、可行性和潜在高影响的干预措施,以解决育龄妇女中可改变的风险因素,这一点至关重要。
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引用次数: 1
Changes in Body Composition, Basal Metabolic Rate, and Blood Albumin during the First Year following Laparoscopic Mini-Gastric Bypass. 腹腔镜迷你胃旁路术后第一年身体组成、基础代谢率和血白蛋白的变化。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-06-28 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7485736
Adnan Tizmaghz, Mansour Bahardoust, Mostafa Hosseini, Abdulreza Pazouki, Hamidreza Alizadeh Otaghvar, Ghazaal Shabestanipour

Bariatric surgery is currently the only method that can significantly and continuously reduce weight and improve obesity-related comorbidities in morbidly obese patients. Significant weight loss through bariatric surgery can lead to changes in body composition. This study shows the changes in body composition, basal metabolic rate (BMR), and serum albumin in obese people following bariatric surgery. The study included 880 patients who underwent laparoscopic mini-gastric bypass surgery (LMGBP) between 2016 and 2020. The body mass index (BMI), bioelectrical impedance analysis (BIA), age, gender, blood albumin, WC (waist circumference), HC (hip circumference), BMR, and blood albumin were recorded at 0, 3, 6, and 12 months, postoperatively. The reduction in serum albumin concentration was not consistent with weight loss. Bariatric surgery promotes the breakdown of both fat and lean mass on the arms, torso, and thighs. This size reduction usually aggravates the concomitant skin redundancy in these areas which is a challenge for the plastic surgery team. Interestingly, the rate of lean mass reduction of the arms is faster than that of the torso and thighs. Excessive loss of lean body mass will also lower BMR and lead to subsequent weight gain. Despite the faster loss of proteins and lean mass in somatic areas, internal organs and viscera lose fats faster than proteins. According to this study, visceral proteins are the latest proteins to be affected by weight loss. This finding shows a different metabolic response of viscera comparing to somatic areas.

减肥手术是目前唯一能显著且持续地减轻体重并改善病态肥胖患者肥胖相关合并症的方法。通过减肥手术进行的显著减肥会导致身体成分的改变。本研究显示肥胖患者在减肥手术后身体组成、基础代谢率(BMR)和血清白蛋白的变化。该研究包括880名在2016年至2020年间接受腹腔镜小型胃旁路手术(LMGBP)的患者。分别于术后0、3、6、12个月记录体重指数(BMI)、生物电阻抗分析(BIA)、年龄、性别、血白蛋白、腰围、臀围、BMR、血白蛋白。血清白蛋白浓度的降低与体重减轻不一致。减肥手术促进手臂、躯干和大腿上的脂肪和瘦肉的分解。这种尺寸的减小通常会加剧这些区域的皮肤冗余,这对整形外科团队来说是一个挑战。有趣的是,手臂的瘦质量减少的速度比躯干和大腿的快。瘦体重的过度减少也会降低BMR,导致随后的体重增加。尽管身体部位的蛋白质和瘦肉流失得更快,但内脏和内脏的脂肪流失得比蛋白质快。根据这项研究,内脏蛋白是最新受减肥影响的蛋白质。这一发现表明,与躯体区域相比,内脏的代谢反应不同。
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引用次数: 2
Can Obesity Prevalence Explain COVID-19 Indicators (Cases, Mortality, and Recovery)? A Comparative Study in OECD Countries. 肥胖患病率能否解释COVID-19指标(病例、死亡率和康复)?经合组织国家比较研究。
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-06-20 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4320120
Yuval Arbel, Chaim Fialkoff, Amichai Kerner, Miryam Kerner

SARS-CoV-2 virus disease (COVID-19) is declared a global pandemic with multiple risk factors. Obesity is considered by several researchers as one of the serious risk factors for SARS-CoV-2 virus complications based on recent empirical studies. Yet, other scholars argue in favor of the existence of an obesity survival paradox and criticize the former group of studies on the grounds that they lack controls for race, socioeconomic status, or quality of care. The objective of the current study is to analyze the potential relationships between different SARS-CoV-2 virus indicators and obesity on a country-wide level based on an OECD report. In an attempt to test the counterintuitive possibility of an obesity survival paradox, the proposed empirical model relaxes the assumption of monotonic change by applying the quadratic design and testing which one of the two competing models (i.e., quadratic or linear) better fits the data. Findings suggest more complex relationships between SARS-CoV-2 virus indices and obesity rates than previously thought. Consequently, ethical guidelines referring to priority in intubation and intensive care treatments-published by the Israeli Ministry of Health in April 2020-should account for these complex relationships between obesity and SARS-CoV-2 virus. Indeed, there is a linear increase in mortality rate from SARS-CoV-2 virus with an elevated prevalence of obesity. Yet, other indicators, such as the number of infected per 10,00,000 persons, rates of severe SARS-CoV-2 virus cases, rates of recovered SARS-CoV-2 virus patients, and SARS-CoV-2 virus, as the cause of death exhibit quadratic, rather than linear, patterns. The reasons for these nonlinear patterns might be explained by several conditions such as increased metabolic reserves, more aggressive treatment, other non-SARS-CoV-2 virus complications for obese persons, and unidentified factors that should be examined in future research.

SARS-CoV-2病毒病(COVID-19)被宣布为具有多重危险因素的全球大流行。根据最近的实证研究,肥胖被一些研究人员认为是SARS-CoV-2病毒并发症的严重危险因素之一。然而,其他学者认为存在肥胖生存悖论,并批评前一组研究,理由是他们缺乏对种族,社会经济地位或护理质量的控制。本次研究的目的是,以经合组织(OECD)的报告为基础,分析不同SARS-CoV-2病毒指标与全国肥胖之间的潜在关系。为了检验肥胖生存悖论的反直觉可能性,提出的经验模型通过应用二次设计并检验两种相互竞争的模型(即二次模型或线性模型)中哪一种更适合数据,从而放宽了单调变化的假设。研究结果表明,SARS-CoV-2病毒指数与肥胖率之间的关系比之前认为的更为复杂。因此,以色列卫生部于2020年4月发布的关于插管和重症监护治疗优先的伦理准则应该考虑到肥胖与SARS-CoV-2病毒之间的这些复杂关系。事实上,SARS-CoV-2病毒的死亡率呈线性上升,肥胖的患病率也在上升。然而,作为死亡原因的其他指标,如每10万人感染人数、严重SARS-CoV-2病毒病例率、SARS-CoV-2病毒患者康复率和SARS-CoV-2病毒,呈现出二次曲线,而不是线性曲线。这些非线性模式的原因可能由几种情况解释,如代谢储备增加、更积极的治疗、肥胖人群的其他非sars - cov -2病毒并发症,以及应在未来研究中检查的未知因素。
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引用次数: 4
Possible Nonneurological Health Benefits of Ketogenic Diet: Review of Scientific Reports over the Past Decade 生酮饮食可能的非神经系统健康益处:回顾过去十年的科学报告
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-05-27 DOI: 10.1155/2022/7531518
Katarzyna Daria Gołąbek, B. Regulska-Ilow
The ketogenic diet (KD) has been used since the 1920s as a therapy for drug-resistant epilepsy. Due to the beneficial effects of this diet on the nervous system and the proposed multifaceted effects of ketones on health and disease, researchers have evaluated its use in other nonneurological conditions. The objective of this review was to analyze the most recent papers, which is why meta-analyses were used in which 75% of the studies were from 2012 to 2022. Authors also cited single studies from the last decade that lasted longer than 12 months to assess the long-term benefits of KD. Reports from the past decade have highlighted several significant areas regarding the impact of KD. One of these is the use of very low-calorie ketogenic diet (VLCKD) as an effective possibly safe and patient-motivating component of a long-term weight loss plan. Reports on the positive influence of KD on the health of obese individuals, and the possible resulting validity of its use, should be verified by patients' physical activity levels. A significant number of studies from the last decade evaluate the effect of KD on improving the health of individuals with type 2 diabetes as an effective tool in lowering glycated hemoglobin (Hb1Ac) and required doses of hypoglycemic drugs. The long-term studies indicate a possible beneficial effect of KD on cardiovascular function due to improvement lipid profile, changes in apolipoprotein (Apo) A1, adiponectin, and intercellular adhesion molecule-1 (ICAM-1).
生酮饮食(KD)自20世纪20年代以来一直用于治疗耐药性癫痫。由于这种饮食对神经系统的有益影响,以及酮类对健康和疾病的多方面影响,研究人员已经评估了它在其他非神经系统疾病中的应用。本综述的目的是分析最新的论文,这就是为什么75%的研究是在2012年至2022年期间进行的,因此使用了荟萃分析。作者还引用了过去十年中持续时间超过12个月的单一研究来评估KD的长期益处。过去十年的报告强调了KD影响的几个重要领域。其中之一是使用极低卡路里生酮饮食(VLCKD)作为长期减肥计划中有效且安全且激励患者的组成部分。关于KD对肥胖个体健康的积极影响的报告,以及可能产生的使用有效性,应该通过患者的身体活动水平来验证。在过去的十年中,大量的研究评估了KD作为降低糖化血红蛋白(Hb1Ac)和降糖药所需剂量的有效工具对改善2型糖尿病患者健康的影响。长期研究表明,KD可能通过改善血脂、改变载脂蛋白(Apo) A1、脂联素和细胞间粘附分子-1 (ICAM-1)对心血管功能产生有益影响。
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引用次数: 1
Relationship between Emotional Eating, Consumption of Hyperpalatable Energy-Dense Foods, and Indicators of Nutritional Status: A Systematic Review. 情绪化饮食、高适口性高能量食物的消耗与营养状况指标之间的关系:一项系统综述
IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-05-18 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4243868
Cristina Elizabeth Fuente González, Jorge Luis Chávez-Servín, Karina de la Torre-Carbot, Dolores Ronquillo González, María de Los Ángeles Aguilera Barreiro, Laura Regina Ojeda Navarro

People's health is closely linked to their diet. Diet can be defined as the set of foods that are consumed in a day, and it is susceptible to being altered by various factors, such as physiological, environmental, psychological, and social. These, in turn, can be affected by an inadequate diet and/or a dysregulation of emotions. Emotions are an immediate response by the organism informing it of the degree of favorability of a certain stimulus or situation. Moods are similar to emotions but more intense and prolonged. Some studies indicate that the consumption of hyperpalatable energy-dense foods may be related to emotional eating. Emotional eating is characterized by the excessive consumption of hyperpalatable energy-dense foods, rich in sugars and fats, in response to negative emotions. But several reports also indicate that emotional eating may be associated with the presence of positive emotions, so further analysis of the available information is necessary. Consuming higher amounts of hyperpalatable energy-dense foods can lead to the accumulation of energy in the body that results in an increase in body weight, as well as other associated diseases. Obesity is the world's leading diet-related health problem. The objective of this work was to carry out a systematic review of the available literature using the Cochrane methodology, in accordance with the PRISMA guidelines, to evaluate the relationship between emotional eating, the consumption of hyperpalatable energy-dense foods, and indicators of nutritional status. An exhaustive search in different databases yielded 9431 scientific articles, 45 of which met the inclusion criteria. This review underscores the fact that knowing and understanding the reasons why people consume hyperpalatable energy-dense foods and the possible connection with their emotional eating can provide key data for improving and personalizing patients' nutritional treatment. This in turn can encourage compliance with treatment plans to improve people's health and quality of life using an interdisciplinary approach.

人们的健康与饮食密切相关。饮食可以定义为一天中消耗的一组食物,它容易受到生理、环境、心理和社会等各种因素的改变。这些反过来又会受到饮食不足和/或情绪失调的影响。情绪是生物体的一种即时反应,它告诉它某种刺激或情况的有利程度。情绪与情绪相似,但更强烈、更持久。一些研究表明,食用美味的高能量食物可能与情绪化进食有关。情绪化饮食的特点是过度食用高美味的高能量食物,富含糖和脂肪,以应对负面情绪。但一些报告也表明,情绪化进食可能与积极情绪的存在有关,因此对现有信息的进一步分析是必要的。摄入大量高美味的高能量食物会导致体内能量的积累,从而导致体重增加,以及其他相关疾病。肥胖是世界上主要的与饮食有关的健康问题。这项工作的目的是根据PRISMA指南,使用Cochrane方法对现有文献进行系统回顾,以评估情绪性饮食、高美味能量密度食物的消费和营养状况指标之间的关系。在不同的数据库中进行了详尽的搜索,产生了9431篇科学文章,其中45篇符合纳入标准。这篇综述强调了这样一个事实,即了解和理解人们食用高美味能量密度食物的原因以及他们情绪化进食的可能联系,可以为改善和个性化患者的营养治疗提供关键数据。这反过来又可以鼓励遵守治疗计划,利用跨学科方法改善人们的健康和生活质量。
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引用次数: 0
10-Year Weight Gain in 13,802 US Adults: The Role of Age, Sex, and Race. 13802名美国成年人10年体重增加:年龄、性别和种族的作用
IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-05-06 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7652408
Larry A Tucker, Kayla Parker

Purpose: The primary objective of the present investigation was to identify 10-year weight gain patterns in 13,802 US adults and also to determine the extent that differences in 10-year weight gains were associated with the key demographic variables: age, sex, and race.

Methods: The study design was cross-sectional and included the years 2011-2018. Data for 2019-2020 were not available because of COVID. A multistage random sampling strategy was employed. Specifically, individual sample weights and randomly selected clusters and strata were used with each statistical model, allowing the results to be generalized to the US adult population.

Results: Mean (±SE) 10-year weight gain was 4.2 ± 0.2 kg or 6.6 ± 0.2% of initial body weight. A total of 51% of the participants gained 5% or more body weight, 36% gained 10% or more, and 16% gained 20% or more across the 10-years. Age was linearly and inversely associated with 10-year weight gain, expressed in kg (F = 166.4, P < 0.0001) or percent weight gain (F = 246.9, P < 0.0001), after adjusting for sex and race. For each 1-year increase in age, 10-year weight gain decreased by 0.20 ± 0.02 kg and 0.28 ± 0.02 percent. After adjusting for age and race, 10-year weight gain (kg) was significantly greater (F = 73.6, P < 0.0001) in women (5.4 ± 0.3) than in men (2.6 ± 0.2). Weight gain also differed across races, kg (F = 27.7, P < 0.0001) and % (F = 28.5, P < 0.0001). Non-Hispanic Blacks gained more weight and NH Asians gained less weight than the other races.

Conclusion: Without question, 10-year weight gain is a serious problem within the US adult population. Younger adults, women, and Non-Hispanic Blacks, particularly Black women, seem to experience the highest levels of 10-year weight gain. Consequently, obesity and weight gain prevention programs focusing on these at-risk individuals should be a public health priority.

目的本研究的主要目的是确定13802名美国成年人的10年体重增加模式,并确定10年体重增长的差异与关键人口统计学变量(年龄、性别和种族)的相关性。方法研究设计为横断面,包括2011-2018年。由于新冠肺炎,2019年至2020年的数据不可用。采用了多级随机抽样策略。具体而言,每个统计模型都使用了个体样本权重和随机选择的聚类和阶层,从而将结果推广到美国成年人群。结果10年平均(±SE)体重增加4.2 ± 0.2 kg或6.6 ± 初始体重的0.2%。在这10年里,共有51%的参与者体重增加了5%或更多,36%的参与者体重增长了10%或更多,16%的参与者体重增重了20%或更多。年龄与10年体重增加呈线性和负相关,单位为kg(F = 166.4,P<0.0001)或体重增加百分比(F = 246.9,P<0.0001)。年龄每增加1年,10年的体重增加就减少0.20 ± 0.02 kg和0.28 ± 0.02%。在对年龄和种族进行调整后,10年的体重增加(kg)明显更大(F = 73.6,P<0.0001)(5.4 ± 0.3)高于男性(2.6 ± 0.2)。不同种族的体重增加也有所不同,kg(F = 27.7,P<0.0001)和%(F = 28.5,P<0.0001)。与其他种族相比,非西班牙裔黑人的体重增加更多,而非西班牙裔亚洲人的体重增加更少。结论毫无疑问,在美国成年人群中,10年的体重增加是一个严重的问题。年轻人、女性和非西班牙裔黑人,尤其是黑人女性,似乎经历了最高水平的10年体重增加。因此,针对这些高危人群的肥胖和体重增加预防计划应该成为公共卫生的优先事项。
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引用次数: 0
Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats 对-Cymene对链脲佐菌素诱导的Wistar大鼠糖尿病脂质、肝酶和Akt/Mtor通路的治疗作用
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-04-26 DOI: 10.1155/2022/1015669
Maryam Arabloei Sani, P. Yaghmaei, Z. Hajebrahimi, N. Hayati Roodbari
Diabetes is a serious public health problem in low- and middle-income countries. There is a strong link between hyperglycemia, oxidative stress, inflammation, and the development of diabetes mellitus. PI3K/Akt/mTOR is the main signaling pathway of insulin for controlling lipid and glucose metabolism. P-cymene is an aromatic monoterpene with a widespread range of therapeutic properties including antioxidant and anti-inflammatory activity. In the present study, the antidiabetic effects of p-cymene were investigated. Diabetes was induced using streptozotocin in male Wistar rats. The effects of p-cymene and metformin were studied on levels of glucose (Glu), lipid profile, liver enzymes, oxidative stress, and the expression of Akt, phospho-Akt, and mTOR (mammalian target of rapamycin) proteins, using biochemical, histological, and immunohistochemical analysis. Data have shown that p-cymene can improve serum levels of Glu, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), and the expression of mTOR, Akt, and phospho-Akt protein in diabetic animals. These results suggest that p-cymene has hypoglycemia, hypolipidemia, and antioxidant properties. It can regulate Akt/mTOR pathway and reduce hepatic and pancreas injury. It can be suggested for diabetes management alone or simultaneously with metformin.
糖尿病在低收入和中等收入国家是一个严重的公共卫生问题。高血糖、氧化应激、炎症和糖尿病的发展之间有着密切的联系。PI3K/Akt/mTOR是胰岛素控制脂糖代谢的主要信号通路。对伞花烯是一种芳香单萜,具有广泛的抗氧化和抗炎活性。本文研究了对伞花烃的抗糖尿病作用。用链脲佐菌素诱导雄性Wistar大鼠患糖尿病。通过生化、组织学和免疫组织化学分析,研究了对花茉莉烯和二甲双胍对小鼠葡萄糖(Glu)、血脂、肝酶、氧化应激水平以及Akt、磷酸化Akt和mTOR(哺乳动物雷帕霉素靶蛋白)蛋白表达的影响。有数据表明,对花香烃能提高糖尿病动物血清Glu、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白(LDL)、极低密度脂蛋白(VLDL)、碱性磷酸酶(ALP)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、丙二醛(MDA)水平,以及mTOR、Akt、phospho-Akt蛋白的表达。这些结果表明,对伞花烃具有降血糖、降血脂和抗氧化的特性。可调节Akt/mTOR通路,减轻肝、胰腺损伤。可建议单独或同时与二甲双胍治疗糖尿病。
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引用次数: 7
Association of Anthropometric Indices with Menstrual Abnormality among Nursing Students of Nepal: A Cross-Sectional Study 尼泊尔护生人体测量指标与月经异常的关系:一项横断面研究
IF 3.3 Q2 ENDOCRINOLOGY & METABOLISM Pub Date : 2022-03-18 DOI: 10.1155/2022/6755436
K. Amgain, Prativa Subedi, G. Yadav, Sujana Neupane, S. Khadka, S. Sapkota
Introduction Obesity has been reported to be linked with menstrual abnormalities including abnormality in cycle length, duration, and period blood loss. However, which anthropometric parameter is a better marker of menstrual abnormality is yet unknown. This study aims to explore the association of BMI, waist-hip ratio (WHR), and waist-height ratio (WHtR) with menstrual abnormalities. Methods This was a cross-sectional study conducted among 240 nursing students on two nursing campuses of Nepal. Demographic and menstrual characteristics related data were collected from the participants via the face-to-face interview technique followed by anthropometric measurements. Binary logistic regression was used to study the association of BMI, WHR, and WHtR with menstrual characteristics. Univariable and multivariable regression models were calculated at 95% confidence interval and a P value of 0.05 using a Statistical Package for Social Sciences, IBM SPSS® v21 (IBM, Armonk, New York). Results Out of 240 participants, 52 participants (21.67%) were underweight (<18.5 kg/m2), and 47 participants (19.58%) were either overweight (≥23 kg/m2) or obese (≥25 kg/m2). Overweight and obese BMI was associated with abnormality in menstrual cycle length (AOR = 4.24; 95% CI = 1.77–10.17), duration of the menstrual period (AOR = 2.52; 95% CI = 1.09–5.81), and periodic menstrual blood loss (AOR = 9.04; 95% CI = 3.55–23.01). Increase in WHtR (>0.5) was associated with abnormal cycle length (AOR = 3.09; 95% CI = 1.09–8.80) and abnormal period duration (AOR = 3.05; 95% CI = 1.10–8.44). An increase in WHR (>0.8) was associated with abnormal cyclical menstrual blood loss (AOR = 4.93; 95% CI = 1.55–15.71). Conclusions Obesity predisposes to menstrual irregularities. BMI is a better predictor of menstrual irregularity as the increase in BMI is associated with abnormality in menstrual cycle length, period duration, and blood loss. Increased WHR was associated with periodic blood loss only. Increased WHtR was associated with abnormal cycle length and period duration, but not menstrual blood loss.
据报道,肥胖与月经异常有关,包括月经周期长度、持续时间和月经失血异常。然而,哪个人体测量参数是一个更好的月经异常的标志尚不清楚。本研究旨在探讨BMI、腰臀比(WHR)、腰高比(WHtR)与月经异常的关系。方法采用横断面研究方法,对尼泊尔两所护理学院的240名护生进行调查。通过面对面访谈技术收集参与者的人口统计学和月经特征相关数据,然后进行人体测量。采用二元logistic回归研究BMI、腰臀比和腰臀比与月经特征的关系。单变量和多变量回归模型采用IBM SPSS®v21 (IBM, Armonk, New York)社会科学统计软件包,以95%置信区间和P值0.05计算。结果240名受试者中,52名(21.67%)体重不足(0.5)与异常周期长度相关(AOR = 3.09;95% CI = 1.09-8.80)和异常期持续时间(AOR = 3.05;95% ci = 1.10-8.44)。WHR升高(>.8)与异常周期性月经失血量相关(AOR = 4.93;95% ci = 1.55-15.71)。结论肥胖易导致月经不规律。BMI是一个更好的预测月经不规律的指标,因为BMI的增加与月经周期长度、经期持续时间和失血异常有关。腰宽比增加仅与周期性失血有关。WHtR增加与异常周期长度和月经持续时间有关,但与月经出血量无关。
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引用次数: 2
期刊
Journal of Obesity
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