Pub Date : 2023-04-19DOI: 10.9734/ajrid/2023/v13i1255
D. E. Adirimo, Nedie Patience Akani, T. Sampson
Objectives: To isolate, identify and determine the prevalence of Staphylococcus aureus among Female Patients attending Rivers State University Teaching Hospital in Port Harcourt using High Vaginal Swab samples. Methods: A cross-sectional study was carried out on total of 103 female patients attending the outpatients department and Antenatal clinic of Rivers State University Teaching Hospital. High Vaginal Swab samples were aseptically collected from 55 non-pregnant and 48 six weeks postpartum women. These were then analysed in the Microbiology Laboratory of the Hospital, following standard microbiological procedures. Questions on age, number of sexual partners, knowledge of vaginal infection, symptomatic case, History of previous infection and treatments was responded to by each participant through the completing of questionnaires. Mannitol Salt Agar (MSA) was used for the isolation of the organism and their phenotypic traits were determined based on their cultural and biochemical characteristics. Results: The study revealed that 25 (24.3%) consisting of 20 (36.4%) non-pregnant women and 5 (10.4%) Postpartum women were positive for Staphylococcus aureus infection. The prevalence of S. aureus among different groups was statistically significant, (P= .002). The highest percentage of S. aureus isolation (36.4%) was found in non-pregnant population. Prevalence of S. aureus was found highest 10 (18.2%) in 21-25 age group among non-pregnant women and none in 26-30 age group among postpartum women. Data obtained from the questionnaires returned showed that 10 (40%) that tested positive for the organism were asymptomatic as at the time of sample collection, had history of previous reproductive tract infection and had previously undergone treatment. Conclusion: The high rate of vaginal Staphylococcal colonisation observed and the positive correlation between Staphylococus aureus prevalence and age, Child delivery status as well as treatment of previous reproductive tract infection seen in the study suggests the need for awareness on the importance of personal hygiene, proper antibiotic usage and regular screening of females within reproductive age.
{"title":"Prevalence of Staphylococcus aureus among Female Patients Attending Rivers State University Teaching Hospital (RSUTH) in Port Harcourt, Nigeria","authors":"D. E. Adirimo, Nedie Patience Akani, T. Sampson","doi":"10.9734/ajrid/2023/v13i1255","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v13i1255","url":null,"abstract":"Objectives: To isolate, identify and determine the prevalence of Staphylococcus aureus among Female Patients attending Rivers State University Teaching Hospital in Port Harcourt using High Vaginal Swab samples. \u0000Methods: A cross-sectional study was carried out on total of 103 female patients attending the outpatients department and Antenatal clinic of Rivers State University Teaching Hospital. High Vaginal Swab samples were aseptically collected from 55 non-pregnant and 48 six weeks postpartum women. These were then analysed in the Microbiology Laboratory of the Hospital, following standard microbiological procedures. Questions on age, number of sexual partners, knowledge of vaginal infection, symptomatic case, History of previous infection and treatments was responded to by each participant through the completing of questionnaires. Mannitol Salt Agar (MSA) was used for the isolation of the organism and their phenotypic traits were determined based on their cultural and biochemical characteristics. \u0000Results: The study revealed that 25 (24.3%) consisting of 20 (36.4%) non-pregnant women and 5 (10.4%) Postpartum women were positive for Staphylococcus aureus infection. The prevalence of S. aureus among different groups was statistically significant, (P= .002). The highest percentage of S. aureus isolation (36.4%) was found in non-pregnant population. Prevalence of S. aureus was found highest 10 (18.2%) in 21-25 age group among non-pregnant women and none in 26-30 age group among postpartum women. Data obtained from the questionnaires returned showed that 10 (40%) that tested positive for the organism were asymptomatic as at the time of sample collection, had history of previous reproductive tract infection and had previously undergone treatment. \u0000Conclusion: The high rate of vaginal Staphylococcal colonisation observed and the positive correlation between Staphylococus aureus prevalence and age, Child delivery status as well as treatment of previous reproductive tract infection seen in the study suggests the need for awareness on the importance of personal hygiene, proper antibiotic usage and regular screening of females within reproductive age.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130409643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-13DOI: 10.9734/ajrid/2023/v13i1254
Kavita Chaudhry, G. Kaur, Priyanshu Kumar
Aims: Hepatitis B virus infection is a global health concern. Although Hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver and can present as full fledged proximal myopathy. Presentation of Case: We report a 68-year-old man presenting with progressive proximal bilateral lower limb weakness for the last 14 days. The weakness was associated with pain and one episode of fever. Examination revealed 3/5 power in the shoulder and hip joint without any sensory deficit. Biochemical investigation showed elevated CPK levels (1102 IU/L) and liver enzymes (AST – 625 IU/L, ALT – 356 IU/L). HBsAg and HBeAg came out to be positive with HBV DNA of 73000 copies/mL. MRI shoulder and hip joints revealed diffuse intramuscular and myofascial edema suggesting inflammatory myositis. Muscle biopsy was suggestive of Necrotizing Autoimmune Myopathy. Discussion: Patient symptoms improved after starting IV Prednisolone and Entecavir therapy suggesting a close association between Hepatitis B infection and myopathy. Conclusion: Although Hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver, such as Polymyositis. Therefore, it is imperative to screen for Viral markers in these patients.
目的:乙型肝炎病毒感染是一个全球性的健康问题。虽然乙型肝炎病毒主要影响肝细胞,但有时在肝外出现疾病表现,并可表现为完全的近端肌病。病例介绍:我们报告一位68岁的男性,在过去的14天里表现为进行性双侧下肢近端无力。虚弱伴有疼痛和一次发热。检查显示肩部和髋关节有3/5的力量,没有感觉障碍。生化检查显示CPK水平升高(1102 IU/L),肝酶水平升高(AST - 625 IU/L, ALT - 356 IU/L)。HBsAg、HBeAg阳性,HBV DNA为73000拷贝/mL。肩关节和髋关节MRI显示弥漫性肌内和肌筋膜水肿提示炎症性肌炎。肌肉活检提示坏死性自身免疫性肌病。讨论:开始静脉注射强的松龙和恩替卡韦治疗后,患者症状有所改善,提示乙型肝炎感染与肌病密切相关。结论:乙型肝炎病毒虽然主要影响肝细胞,但有时也会出现肝外病变表现,如多发性肌炎。因此,筛查这些患者的病毒标志物是必要的。
{"title":"The Association of Hepatitis B and Polymyositis: Rare but Real","authors":"Kavita Chaudhry, G. Kaur, Priyanshu Kumar","doi":"10.9734/ajrid/2023/v13i1254","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v13i1254","url":null,"abstract":"Aims: Hepatitis B virus infection is a global health concern. Although Hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver and can present as full fledged proximal myopathy. \u0000Presentation of Case: We report a 68-year-old man presenting with progressive proximal bilateral lower limb weakness for the last 14 days. The weakness was associated with pain and one episode of fever. Examination revealed 3/5 power in the shoulder and hip joint without any sensory deficit. Biochemical investigation showed elevated CPK levels (1102 IU/L) and liver enzymes (AST – 625 IU/L, ALT – 356 IU/L). HBsAg and HBeAg came out to be positive with HBV DNA of 73000 copies/mL. MRI shoulder and hip joints revealed diffuse intramuscular and myofascial edema suggesting inflammatory myositis. Muscle biopsy was suggestive of Necrotizing Autoimmune Myopathy. \u0000Discussion: Patient symptoms improved after starting IV Prednisolone and Entecavir therapy suggesting a close association between Hepatitis B infection and myopathy. \u0000Conclusion: Although Hepatitis B virus primarily affects hepatocytes, it sometimes develops disease manifestations outside the liver, such as Polymyositis. Therefore, it is imperative to screen for Viral markers in these patients.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124563022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-11DOI: 10.9734/ajrid/2023/v12i4253
Premature rupture of membranes (PROM) is the spontaneous rupture of the membranes before the onset of signs of labor. It can occur both before term (<37 weeks) and after term (> 37 weeks). Caesarean delivery is a surgical technique to deliver the fetus through an incision in the abdominal wall and uterine wall. This procedure is performed to minimize all complications from premature rupture of membranes. This study aims to determine the relationship between premature rupture of membranes and delivery of sectio caesarea at the UKI General Hospital in the 2019 period by using a descriptive content analysis method (analysis of medical records documents) with a cross-sectional approach and obtained 65 samples who experienced premature rupture of membranes. The results showed that 53 samples (81.55%) experienced premature rupture of membranes and performed sectio caesarea, while 12 samples (18.45%) had premature rupture of membranes but did not perform sectio caesarea with p-value = 0.001 (p <0.05) from the results of the chi-square statistical test. From the results of the analysis, it was found that there was a relationship between premature rupture of membranes and delivery of cesarean section at the UKI General Hospital for the 2019 period. It is suggested that patients avoid the factors that can cause premature rupture of the membranes, which have been told by the doctor or health worker and the patient's family to support the patient to remind them to avoid factors that can cause premature rupture of the membranes.
{"title":"Relationship between Premature Rupture of the Membrane and Cesarean Delivery: Case from Jakarta, Indonesia","authors":"","doi":"10.9734/ajrid/2023/v12i4253","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i4253","url":null,"abstract":"Premature rupture of membranes (PROM) is the spontaneous rupture of the membranes before the onset of signs of labor. It can occur both before term (<37 weeks) and after term (> 37 weeks). Caesarean delivery is a surgical technique to deliver the fetus through an incision in the abdominal wall and uterine wall. This procedure is performed to minimize all complications from premature rupture of membranes. This study aims to determine the relationship between premature rupture of membranes and delivery of sectio caesarea at the UKI General Hospital in the 2019 period by using a descriptive content analysis method (analysis of medical records documents) with a cross-sectional approach and obtained 65 samples who experienced premature rupture of membranes. The results showed that 53 samples (81.55%) experienced premature rupture of membranes and performed sectio caesarea, while 12 samples (18.45%) had premature rupture of membranes but did not perform sectio caesarea with p-value = 0.001 (p <0.05) from the results of the chi-square statistical test. From the results of the analysis, it was found that there was a relationship between premature rupture of membranes and delivery of cesarean section at the UKI General Hospital for the 2019 period. It is suggested that patients avoid the factors that can cause premature rupture of the membranes, which have been told by the doctor or health worker and the patient's family to support the patient to remind them to avoid factors that can cause premature rupture of the membranes.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125583446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-05DOI: 10.9734/ajrid/2023/v12i4252
B. Balarabe-Musa
Introduction: Nigeria had planned to introduce the rotavirus vaccine in the National Immunisation Programme in 2014 but this has yet to be done. Nigeria has the continent’s highest mortality due to diarrhoeal diseases with little information on specific prevalent genotypes. The main objectives of the study were to identify the predominant rotavirus genotypes and to examine the effects of existing local vaccination programmes on prevailing rotavirus genotypes and on preventing rotavirus diarrhoea. Methodology: A one-year prospective descriptive study of children under 5 with acute diarrhoea was conducted from September 2012 to August 2013. Children with acute diarrhoea attending three government hospitals and one private hospital were recruited. Children without diarrhoea were also recruited as a control group. Rotavirus ELISA and RNA extraction were done with commercially available kits and positive samples were subjected to RT-PCR and electrophoresis to determine VP7 (G) and VP4 (P) genotypes. Results: Stool samples were collected from 1240 (93.3%) participants, of whom 957 (77.0%) were ambulatory, 123 (9.9%) hospitalised and 160 (12.8%) controls without diarrhoea. Rotavirus-ELISA was positive among 123 (11.4%) children with diarrhoea. The predominant VP7 genotypes were G2 (n=33, 26.4%) followed by G9 (n=24, 19.2). The main VP4 (P) genotypes included P [4] (n=45, 36.0%) followed by P [6] (n=40, 32.0%). The predominant genotype combinations found were G2 P [4] (n=21, 16.8%), G3 P [6] and G1 P [6] (each n=16, 12.8%), and G12 P [8] (n=15, 12.0%). Very few mixed infections were found in only one government hospital 4 (6.4%). Among 94 unvaccinated children with rotavirus isolates that were genotyped, G2 P [4] (n=19, 20.2%) and G1 P [6] (n=16, 17.0%) were predominant. Among 12 vaccinated children, 2 isolates each (16.6%) were found of G3 P [6], G9 P [4], G12 P [8] and G2 P [NT] with no G1 isolates. Conclusion: The emergence of new genotypes such as G 12 P [8] found in this study emphasizes the need for continued prospective monitoring of rotavirus at the molecular level to detect new threats to vaccine programmes in future.
导言:尼日利亚曾计划在2014年将轮状病毒疫苗纳入国家免疫规划,但这一计划尚未完成。尼日利亚是非洲大陆腹泻病死亡率最高的国家,而关于具体流行基因型的信息很少。该研究的主要目的是确定主要的轮状病毒基因型,并检查现有的地方疫苗接种规划对流行的轮状病毒基因型和预防轮状病毒腹泻的影响。方法:2012年9月至2013年8月对5岁以下急性腹泻患儿进行为期一年的前瞻性描述性研究。在三所政府医院和一所私立医院招募患有急性腹泻的儿童。没有腹泻的儿童也被招募为对照组。采用市售试剂盒对轮状病毒进行酶联免疫吸附试验和RNA提取,阳性样本进行RT-PCR和电泳检测VP7 (G)和VP4 (P)基因型。结果:收集了1240名(93.3%)参与者的粪便样本,其中957名(77.0%)是流动的,123名(9.9%)是住院的,160名(12.8%)是没有腹泻的对照组。123例(11.4%)腹泻患儿轮状病毒elisa阳性。VP7的优势基因型为G2 (n=33, 26.4%),其次为G9 (n=24, 19.2%)。VP4 (P)主要基因型为P [4] (n=45, 36.0%),其次为P [6] (n=40, 32.0%)。主要基因型组合为G2 P [4] (n=21, 16.8%)、G3 P[6]和G1 P[6](各n=16, 12.8%)和G12 P [8] (n=15, 12.0%)。只有一家政府医院4(6.4%)发现了极少数混合感染。在94例未接种疫苗的轮状病毒分离株中,G2 P [4] (n=19, 20.2%)和G1 P [6] (n=16, 17.0%)占主导地位。12例接种儿童中,G3 P[6]、G9 P[4]、G12 P[8]、G2 P [NT]各2株(16.6%),无G1分离株。结论:本研究中发现的g12p[8]等新基因型的出现,强调需要在分子水平上继续对轮状病毒进行前瞻性监测,以发现未来疫苗规划的新威胁。
{"title":"Circulation of Rotavirus Genotypes and their Distribution among Vaccinated and Non-vaccinated Children in Abuja, Nigeria","authors":"B. Balarabe-Musa","doi":"10.9734/ajrid/2023/v12i4252","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i4252","url":null,"abstract":"Introduction: Nigeria had planned to introduce the rotavirus vaccine in the National Immunisation Programme in 2014 but this has yet to be done. Nigeria has the continent’s highest mortality due to diarrhoeal diseases with little information on specific prevalent genotypes. The main objectives of the study were to identify the predominant rotavirus genotypes and to examine the effects of existing local vaccination programmes on prevailing rotavirus genotypes and on preventing rotavirus diarrhoea. \u0000Methodology: A one-year prospective descriptive study of children under 5 with acute diarrhoea was conducted from September 2012 to August 2013. Children with acute diarrhoea attending three government hospitals and one private hospital were recruited. Children without diarrhoea were also recruited as a control group. Rotavirus ELISA and RNA extraction were done with commercially available kits and positive samples were subjected to RT-PCR and electrophoresis to determine VP7 (G) and VP4 (P) genotypes. \u0000Results: Stool samples were collected from 1240 (93.3%) participants, of whom 957 (77.0%) were ambulatory, 123 (9.9%) hospitalised and 160 (12.8%) controls without diarrhoea. Rotavirus-ELISA was positive among 123 (11.4%) children with diarrhoea. The predominant VP7 genotypes were G2 (n=33, 26.4%) followed by G9 (n=24, 19.2). The main VP4 (P) genotypes included P [4] (n=45, 36.0%) followed by P [6] (n=40, 32.0%). The predominant genotype combinations found were G2 P [4] (n=21, 16.8%), G3 P [6] and G1 P [6] (each n=16, 12.8%), and G12 P [8] (n=15, 12.0%). Very few mixed infections were found in only one government hospital 4 (6.4%). Among 94 unvaccinated children with rotavirus isolates that were genotyped, G2 P [4] (n=19, 20.2%) and G1 P [6] (n=16, 17.0%) were predominant. Among 12 vaccinated children, 2 isolates each (16.6%) were found of G3 P [6], G9 P [4], G12 P [8] and G2 P [NT] with no G1 isolates. \u0000Conclusion: The emergence of new genotypes such as G 12 P [8] found in this study emphasizes the need for continued prospective monitoring of rotavirus at the molecular level to detect new threats to vaccine programmes in future.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127792747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.9734/ajrid/2023/v12i4251
M. Noorunnahar, Maksuda Akter Mily, Lima Khatun, Md. Ashiqur Rahman, Rayhan Ahmmed Pranto, Khandoker Saif Uddin
Bangladesh is facing unpredictable weather patterns, as well as a consistent rise in temperature and precipitation. Climate change has had a negative impact on physical and mental health, leading to an increase mostly in the prevalence and variation of infectious diseases, as well as psychological issues such as depression and anxiety disorders. Given the country's inherent sensitivity to climatic influences, the climate-health nexus is a relatively unexplored subject of research. The purpose of this article is to investigate the severity of climate change in Bangladesh and how it impacts the health of the public. Morbidity and mortality due to heat stress, cyclones, floods, droughts, and other weather extremes at various spatiotemporal scales have been observed as direct effects of climate change in Bangladesh. The indirect effects involve more complicated paths, such as affecting food and water security due to salinity intrusion and the development of infectious diseases because of shifts in vector and pathogen ecology. To mitigate the effects of climate change on various infectious diseases, healthcare and response systems must be strengthened. By implementing proactive adaptation methods, we may significantly and actively contribute to preventing and regulating the negative consequences of climate change on human health. There is little evidence to make sound health policy decisions in the context of climate change, and there is a lack of multidisciplinary research activities. Despite these constraints, gathering and reporting scientific information is essential for developing a resilient health system in climate-vulnerable countries like Bangladesh and other low-income regions.
{"title":"How is Bangladesh Growing More Susceptible to Infectious Disease Epidemics as a Result of Climate Change? A Systematic Review","authors":"M. Noorunnahar, Maksuda Akter Mily, Lima Khatun, Md. Ashiqur Rahman, Rayhan Ahmmed Pranto, Khandoker Saif Uddin","doi":"10.9734/ajrid/2023/v12i4251","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i4251","url":null,"abstract":"Bangladesh is facing unpredictable weather patterns, as well as a consistent rise in temperature and precipitation. Climate change has had a negative impact on physical and mental health, leading to an increase mostly in the prevalence and variation of infectious diseases, as well as psychological issues such as depression and anxiety disorders. Given the country's inherent sensitivity to climatic influences, the climate-health nexus is a relatively unexplored subject of research. The purpose of this article is to investigate the severity of climate change in Bangladesh and how it impacts the health of the public. Morbidity and mortality due to heat stress, cyclones, floods, droughts, and other weather extremes at various spatiotemporal scales have been observed as direct effects of climate change in Bangladesh. The indirect effects involve more complicated paths, such as affecting food and water security due to salinity intrusion and the development of infectious diseases because of shifts in vector and pathogen ecology. To mitigate the effects of climate change on various infectious diseases, healthcare and response systems must be strengthened. By implementing proactive adaptation methods, we may significantly and actively contribute to preventing and regulating the negative consequences of climate change on human health. There is little evidence to make sound health policy decisions in the context of climate change, and there is a lack of multidisciplinary research activities. Despite these constraints, gathering and reporting scientific information is essential for developing a resilient health system in climate-vulnerable countries like Bangladesh and other low-income regions.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123550218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-30DOI: 10.9734/ajrid/2023/v12i4250
B. Balarabe-Musa
Background: Diarrhoea is the second leading cause of death in children. Nigeria has the continent’s highest mortality due to diarrhoeal diseases with little information on specific causes and the proportion affected by rotavirus infection. The main objectives of this study were to describe the features of young children with diarrhoea, with and without rotavirus, in Abuja the Federal Capital Territory. Materials and Methods: Retrospective review of local hospital activity data related to diarrhoea was retrieved from General Hospitals in Abuja. Then a one-year prospective descriptive study of children under 5 years of age with acute diarrhoea was conducted from September 2012 to August 2013. Children with acute diarrhoea attending three government hospitals and one private hospital were recruited. Children without diarrhoea were recruited as the control group. Faecal specimens were transported in cold chain boxes from Nigeria and stored at -80 °C at the Institute of Global Health, virology section of the University of Liverpool, where all laboratory work was performed. Results: Hospital records were poorly preserved and did not provide meaningful data for trend analyses or disease surveillance. 1331 participants were enrolled in this prospective study. Stool samples were collected from 1242 (93.3%) participants, of whom 957 (77.0%) were ambulatory, 123 (9.9%) hospitalised and 160 (12.8%) controls without diarrhoea. 881 and 450 children with diarrhoea were recruited from government and the private hospitals, respectively. The median age of the children was 8 months in the ambulatory and 9.5 months in the hospitalized group (p<0.05). A total of 209 (16.8%) children were vaccinated, 858 (69.1%) were unvaccinated, and 174 (14.0%) had an unclear vaccination status. Rotavirus ELISA was positive in 123 (11.4%) children with diarrhoea and 2 (1.2%) controls. Among children with diarrhoea, 92 (10.4%) of 881 children attending government hospitals had rotavirus, compared to 33 (7.3%) of 450 children attending a private hospital (p<0.001) where a vaccination program had been in place. The peak months for rotavirus infection were November and February. The efficacy of Rotarix® RV1 vaccine in preventing rotavirus diarrhoea was indirectly assessed to be 64.5%. Conclusion: Rotavirus is an important pathogen in children, especially in unvaccinated children in Abuja. The introduction of a rotavirus vaccine is highly desirable in Nigeria, but this is still awaited. Local and national infrastructure are inadequate for basic surveillance of diarrhoeal disease, and this will have to be improved, together with access to virological stool testing, to monitor the planned vaccine program. The retrospective studies reported here provide indirect evidence of vaccine efficacy in Abuja but need prospective confirmation.
{"title":"Burden of Rotavirus Diarrhoea in Children in Abuja","authors":"B. Balarabe-Musa","doi":"10.9734/ajrid/2023/v12i4250","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i4250","url":null,"abstract":"Background: Diarrhoea is the second leading cause of death in children. Nigeria has the continent’s highest mortality due to diarrhoeal diseases with little information on specific causes and the proportion affected by rotavirus infection. The main objectives of this study were to describe the features of young children with diarrhoea, with and without rotavirus, in Abuja the Federal Capital Territory. \u0000Materials and Methods: Retrospective review of local hospital activity data related to diarrhoea was retrieved from General Hospitals in Abuja. Then a one-year prospective descriptive study of children under 5 years of age with acute diarrhoea was conducted from September 2012 to August 2013. Children with acute diarrhoea attending three government hospitals and one private hospital were recruited. Children without diarrhoea were recruited as the control group. Faecal specimens were transported in cold chain boxes from Nigeria and stored at -80 °C at the Institute of Global Health, virology section of the University of Liverpool, where all laboratory work was performed. \u0000Results: Hospital records were poorly preserved and did not provide meaningful data for trend analyses or disease surveillance. 1331 participants were enrolled in this prospective study. Stool samples were collected from 1242 (93.3%) participants, of whom 957 (77.0%) were ambulatory, 123 (9.9%) hospitalised and 160 (12.8%) controls without diarrhoea. 881 and 450 children with diarrhoea were recruited from government and the private hospitals, respectively. The median age of the children was 8 months in the ambulatory and 9.5 months in the hospitalized group (p<0.05). A total of 209 (16.8%) children were vaccinated, 858 (69.1%) were unvaccinated, and 174 (14.0%) had an unclear vaccination status. Rotavirus ELISA was positive in 123 (11.4%) children with diarrhoea and 2 (1.2%) controls. Among children with diarrhoea, 92 (10.4%) of 881 children attending government hospitals had rotavirus, compared to 33 (7.3%) of 450 children attending a private hospital (p<0.001) where a vaccination program had been in place. The peak months for rotavirus infection were November and February. The efficacy of Rotarix® RV1 vaccine in preventing rotavirus diarrhoea was indirectly assessed to be 64.5%. \u0000Conclusion: Rotavirus is an important pathogen in children, especially in unvaccinated children in Abuja. The introduction of a rotavirus vaccine is highly desirable in Nigeria, but this is still awaited. Local and national infrastructure are inadequate for basic surveillance of diarrhoeal disease, and this will have to be improved, together with access to virological stool testing, to monitor the planned vaccine program. The retrospective studies reported here provide indirect evidence of vaccine efficacy in Abuja but need prospective confirmation.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"140 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130782256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-16DOI: 10.9734/ajrid/2023/v12i4249
M. Nayan, Tirtha Nandi, R. Ghosh
The global severity of COVID-19 remains high which results anxiety and other mental health problems, also it altered people's everyday lives, affected human connections and economic operations. The goal of this comprehensive review was to identify the effects of the linkage COVID-19 pandemic on the mental health of different groups and communities. This study compiled evidences of a link between anxiety rates and the COVID-19 pandemic. The evaluation period started in June’ 2022 and ended on August’2022, during this time, total four databases such as PubMed, Science Direct, Tailor & Francis Online, and Springer were used to search scientific literatures. A total 616 studies were identified from all four databases and 63 scientific literatures were selected based of predetermined criteria for review which were published in between 2020 to 2022. Three groups of population such as general population, students and healthcare professionals were taken for review the findings from the selected literatures. Gender, physical disorders, psychiatric disorders, COVID infection, infection rates in colleagues or family members, experience of frontline work & non-frontline work, close contact with infected patients, high exposure risk, quarantine experience, etc. were highly considered as factors associated with increased prevalence of anxiety among all three groups. During the COVID-19 pandemic, the general population, healthcare professionals, and students experienced an increase in the prevalence of mental diseases, whereas infected individuals had a decrease. Females were highly prevalent to anxiety than male. Our comprehensive review concluded significant co-relation between anxiety and COVID-19 but long-term study is needed to better understand which may define the population's mental condition in future.
COVID-19的全球严重程度仍然很高,导致焦虑和其他精神健康问题,也改变了人们的日常生活,影响了人际关系和经济运作。这项综合综述的目的是确定COVID-19大流行对不同群体和社区心理健康的影响。这项研究收集了焦虑率与COVID-19大流行之间存在联系的证据。评估期从2022年6月开始至2022年8月结束,在此期间,共使用PubMed、Science Direct、Tailor & Francis Online和Springer四个数据库检索科学文献。从所有四个数据库中共确定了616项研究,并根据预先确定的标准选择了63篇科学文献,这些文献发表于2020年至2022年之间。三组人群,如一般人群,学生和卫生保健专业人员被用于审查所选文献的研究结果。性别、身体障碍、精神障碍、COVID感染、同事或家庭成员感染率、一线和非一线工作经历、与感染患者密切接触、高暴露风险、隔离经历等被高度认为是三组患者焦虑患病率增加的相关因素。在2019冠状病毒病大流行期间,普通人群、卫生保健专业人员和学生的精神疾病患病率上升,而感染者的发病率下降。女性比男性更容易焦虑。我们的综合评价得出焦虑与COVID-19之间存在显着的相关关系,但需要长期研究来更好地了解哪些因素可能决定未来人群的精神状况。
{"title":"Prevalence of Perceived Anxiety in General People, Students and Healthcare Professionals during COVID-19 Pandemic: A Comprehensive Scientific Review","authors":"M. Nayan, Tirtha Nandi, R. Ghosh","doi":"10.9734/ajrid/2023/v12i4249","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i4249","url":null,"abstract":"The global severity of COVID-19 remains high which results anxiety and other mental health problems, also it altered people's everyday lives, affected human connections and economic operations. The goal of this comprehensive review was to identify the effects of the linkage COVID-19 pandemic on the mental health of different groups and communities. This study compiled evidences of a link between anxiety rates and the COVID-19 pandemic. The evaluation period started in June’ 2022 and ended on August’2022, during this time, total four databases such as PubMed, Science Direct, Tailor & Francis Online, and Springer were used to search scientific literatures. A total 616 studies were identified from all four databases and 63 scientific literatures were selected based of predetermined criteria for review which were published in between 2020 to 2022. Three groups of population such as general population, students and healthcare professionals were taken for review the findings from the selected literatures. Gender, physical disorders, psychiatric disorders, COVID infection, infection rates in colleagues or family members, experience of frontline work & non-frontline work, close contact with infected patients, high exposure risk, quarantine experience, etc. were highly considered as factors associated with increased prevalence of anxiety among all three groups. During the COVID-19 pandemic, the general population, healthcare professionals, and students experienced an increase in the prevalence of mental diseases, whereas infected individuals had a decrease. Females were highly prevalent to anxiety than male. Our comprehensive review concluded significant co-relation between anxiety and COVID-19 but long-term study is needed to better understand which may define the population's mental condition in future.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"170 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125462723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-02DOI: 10.9734/ajrid/2023/v12i3248
G. Owhonda, Foster Patrick, C. Eze-Emiri, Ezinne Igwe, G. Arugu, Ihuoma Des-Wosu, Victor Oris-Onyiri, Justice Ohaka, I. Nwadiuto
Introduction: COVID-19 has accounted for approximately six million deaths globally. Several risk factors have been identified. However, the population profile varies in different population groups. The study's aim is to describe the population profile of COVID-19 mortality in Rivers State, Nigeria using captured population-based health records. Methods: Using electronic State Health Records, secondary data analysis was conducted on recorded COVID-19 mortality. Data were obtained from the Public Health Emergency Operations Centre (PHEOC) at the State Ministry of Health, Rivers State. Data were accessed from the PHEOC database, and it included COVID-19 related mortality. Data were collected on demographics, pre-existing comorbidity, symptoms, facility managed, patient status, treatment outcome, and dates of related events. Cohort characteristics were described using means and proportions. Results: There were 191 COVID-19 deaths identified. The mean age was 57.08 years, of which 144 were male (75.4%). The 51–65-year age group had the highest mortality count (38.9%). Over 50% of the patients were hypertensive, and diabetes was the second most common comrbidity (28.8%). Running nose, cough, fever and breathing difficulties were the most reported COVID-19 symptoms. Conclusion: This study found that COVID-19 was responsible for a greater mortality increase in men and that the prevalence of hypertension and diabetes was higher in these individuals. Additionally, age and the presence of comorbidities may be associated with COVID-19 mortality. Future research in this area could further explain these findings.
{"title":"Demographic and Public Health Characteristics of COVID-19 Mortality Cases in Rivers State, Nigeria –A Retrospective Cohort Study","authors":"G. Owhonda, Foster Patrick, C. Eze-Emiri, Ezinne Igwe, G. Arugu, Ihuoma Des-Wosu, Victor Oris-Onyiri, Justice Ohaka, I. Nwadiuto","doi":"10.9734/ajrid/2023/v12i3248","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i3248","url":null,"abstract":"Introduction: COVID-19 has accounted for approximately six million deaths globally. Several risk factors have been identified. However, the population profile varies in different population groups. The study's aim is to describe the population profile of COVID-19 mortality in Rivers State, Nigeria using captured population-based health records.\u0000Methods: Using electronic State Health Records, secondary data analysis was conducted on recorded COVID-19 mortality. Data were obtained from the Public Health Emergency Operations Centre (PHEOC) at the State Ministry of Health, Rivers State. Data were accessed from the PHEOC database, and it included COVID-19 related mortality. Data were collected on demographics, pre-existing comorbidity, symptoms, facility managed, patient status, treatment outcome, and dates of related events. Cohort characteristics were described using means and proportions.\u0000Results: There were 191 COVID-19 deaths identified. The mean age was 57.08 years, of which 144 were male (75.4%). The 51–65-year age group had the highest mortality count (38.9%). Over 50% of the patients were hypertensive, and diabetes was the second most common comrbidity (28.8%). Running nose, cough, fever and breathing difficulties were the most reported COVID-19 symptoms.\u0000Conclusion: This study found that COVID-19 was responsible for a greater mortality increase in men and that the prevalence of hypertension and diabetes was higher in these individuals. Additionally, age and the presence of comorbidities may be associated with COVID-19 mortality. Future research in this area could further explain these findings.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115583425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.9734/ajrid/2023/v12i3246
Issa Yakusu, Baroani Bikenge, P. Kitronza, Ossinga Bassandja, Mfuamba Kadima, Longombe Ahuka Nono, Mankulu N’Sila, B. Agasa
Objectives: This study aimed to determine the level of knowledge, attitudes and practices (KAP) of students of the Faculty of Pharmacy of the University of Kisangani. Methods: A cross-sectional descriptive study was undertaken among students of the Faculty of Pharmacy. KAPs on Covid-19 were assessed using a survey questionnaire. Results: Male students were predominant (50.8%). The majority of respondents were under or equal to 25 years old. The majority had sufficient knowledge (97.4%) provided mainly by television and radio. 63 respondents or 33.3% of cases did not know if the disease exists in Kisangani; and 88.9% had good practices regarding Covid-19. Conclusion: These results showed that most students have a good knowledge of Covid-19; they presented good practices as well as good attitudes.
{"title":"Knowledge, Attitudes and Practices (Kap) on Covid-19 of Students of the Faculty of Pharmacy of the University of Kisangani","authors":"Issa Yakusu, Baroani Bikenge, P. Kitronza, Ossinga Bassandja, Mfuamba Kadima, Longombe Ahuka Nono, Mankulu N’Sila, B. Agasa","doi":"10.9734/ajrid/2023/v12i3246","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i3246","url":null,"abstract":"Objectives: This study aimed to determine the level of knowledge, attitudes and practices (KAP) of students of the Faculty of Pharmacy of the University of Kisangani. \u0000Methods: A cross-sectional descriptive study was undertaken among students of the Faculty of Pharmacy. KAPs on Covid-19 were assessed using a survey questionnaire. \u0000Results: Male students were predominant (50.8%). The majority of respondents were under or equal to 25 years old. The majority had sufficient knowledge (97.4%) provided mainly by television and radio. 63 respondents or 33.3% of cases did not know if the disease exists in Kisangani; and 88.9% had good practices regarding Covid-19. \u0000Conclusion: These results showed that most students have a good knowledge of Covid-19; they presented good practices as well as good attitudes.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133848024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-01DOI: 10.9734/ajrid/2023/v12i3247
H. Narayanan, B. Nandagopal, Mageshbabu Ramamurthy, Kumaran Vadivel
One of the significant causes of morbidity and mortality among young children in developing nations is acute respiratory tract infections (ARTIs). It is also highly contagious, widely prevalent, and transmissible from person to person. It risks young children, the elderly, and those with immune system disorders. Acute respiratory infections are thought to cause 2.6 million child deaths annually worldwide, according to the World Health Organization (WHO) [1]. Infections in children with human metapneumovirus (hMPV) and bocavirus (HBoV) are linked to a high prevalence of ARTIs. It has been determined that hMPV is the second-leading cause of infant bronchiolitis, after the respiratory syncytial virus (RSV), of upper and lower respiratory tract infections. Although HBoV was first discovered in children's airways, the high detection rates of other viral pathogens and the discovery of HBoV in stool raise doubts about the virus's significance in respiratory tract infections. According to the published literature, only a few studies have identified ARTIs or demonstrated the importance of early diagnosis and treatment of ARTIs. This review article aims to thoroughly explain the aetiology, epidemiology, clinical characteristics, diagnostic approaches, and management of hMPV and HBoV.
{"title":"A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections","authors":"H. Narayanan, B. Nandagopal, Mageshbabu Ramamurthy, Kumaran Vadivel","doi":"10.9734/ajrid/2023/v12i3247","DOIUrl":"https://doi.org/10.9734/ajrid/2023/v12i3247","url":null,"abstract":"One of the significant causes of morbidity and mortality among young children in developing nations is acute respiratory tract infections (ARTIs). It is also highly contagious, widely prevalent, and transmissible from person to person. It risks young children, the elderly, and those with immune system disorders. Acute respiratory infections are thought to cause 2.6 million child deaths annually worldwide, according to the World Health Organization (WHO) [1]. Infections in children with human metapneumovirus (hMPV) and bocavirus (HBoV) are linked to a high prevalence of ARTIs. It has been determined that hMPV is the second-leading cause of infant bronchiolitis, after the respiratory syncytial virus (RSV), of upper and lower respiratory tract infections. Although HBoV was first discovered in children's airways, the high detection rates of other viral pathogens and the discovery of HBoV in stool raise doubts about the virus's significance in respiratory tract infections. According to the published literature, only a few studies have identified ARTIs or demonstrated the importance of early diagnosis and treatment of ARTIs. This review article aims to thoroughly explain the aetiology, epidemiology, clinical characteristics, diagnostic approaches, and management of hMPV and HBoV.","PeriodicalId":166387,"journal":{"name":"Asian Journal of Research in Infectious Diseases","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123609608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}