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Instruments to measure patient satisfaction with comprehensive medication management (CMM) services: a scoping review 测量患者对综合用药管理(CMM)服务满意度的工具:范围审查
Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-10-10 DOI: 10.1093/jphsr/rmad044
Lorayne Caroline Resende, Mariana Michel Barbosa, Cristiane de Paula Rezende, Laís Lessa Neiva Pantuza, Edna Afonso Reis, Mariana Martins Gonzaga Nascimento
Abstract Objectives To map the instruments to measure patient satisfaction with comprehensive medication management (CMM) services and to compare them according to their development characteristics and applicability of patient-reported outcome measures (PRO) measures. Methods A scoping review was conducted using the methodology proposed by the Joanna Briggs Institute and the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Studies that developed or applied a patient satisfaction measurement instrument in CMM services, published from 1990 onwards were selected. The critical appraisal of the instruments identified was carried out using an 18 item checklist developed to systematically evaluate PRO measures. Key findings A total of 28 studies were selected; in most (17), the applied instruments had been developed by the authors. Nine of them were validated, most of which used open-ended and closed questions in self-administered printed instruments. The best-qualified instrument reached 11 out of the 18 evaluated items, highlighting the difficulty in the definition of the satisfaction construct. Conclusions The review made it possible to identify the instruments available to measure patient satisfaction with CMM services and to comparatively highlight their characteristics and psychometric properties. It also pointed out the need to improve or develop a patient satisfaction instrument for CMM services. However, improvement is needed in many of the evaluated domains of the instruments to meet the desirable requirements for a PRO measure. These gaps should be taken into consideration in future research, aiming to build a robust and standardized instrument for the CMM service.
【摘要】目的绘制综合用药管理(CMM)服务满意度测评工具图谱,比较其发展特点和患者报告结果测量(PRO)指标的适用性。方法采用乔安娜布里格斯研究所和PRISMA范围审查扩展(PRISMA- scr)提出的方法进行范围审查。研究开发或应用的病人满意度测量工具在CMM服务,从1990年以来发表的选择。对所确定的仪器进行了批判性评估,使用了一份18项清单来系统地评估PRO措施。本研究共纳入28项研究;在大多数(17)中,应用的仪器是由作者开发的。其中9项已得到验证,其中大多数在自行管理的印刷文书中使用开放式和封闭式问题。在18个评估项目中,最合格的工具达到了11个,突出了满意度结构定义的难度。结论本综述确定了可用的测量CMM服务患者满意度的工具,并比较突出了它们的特点和心理测量学性质。报告还指出,有必要改进或开发一种患者满意度测量工具。然而,仪器的许多评估领域需要改进,以满足PRO测量的理想要求。这些差距应该在未来的研究中加以考虑,旨在为CMM服务建立一个健壮和标准化的仪器。
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引用次数: 0
Antimicrobial stewardship: community pharmacists’ antibiotic dispensing practices, knowledge, and perception regarding antibiotics and antibiotic resistance 抗菌药物管理:社区药剂师的抗生素配药实践,知识和感知有关抗生素和抗生素耐药性
Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-09-18 DOI: 10.1093/jphsr/rmad040
Wuraola Akande-Sholabi, Eunice Oyesiji, Yusuff Adebayo Adebisi
Abstract Objectives Antimicrobial resistance is a major global health threat, and the inappropriate use of antibiotics is a key driver of this phenomenon. Community pharmacists play a crucial role in the responsible use of antibiotics and in promoting antimicrobial stewardship. This study assessed the knowledge and perception of community pharmacists regarding antibiotics and antibiotic resistance as well as their antibiotic dispensing practices. Methods This was a cross-sectional survey conducted among 126 community pharmacists in Ibadan, with the use of a self-administered paper questionnaire. The questionnaire contained Likert-type 8-item knowledge, 5-item perception, and 18-item dispensing practice scales. The scaled score was graded as adequate and inadequate knowledge, and good or poor dispensing practices. Data were analysed using SPSS (version 25) and results are presented using descriptive statistics. Key findings Adequate knowledge of antibiotics and antibiotic resistance was demonstrated by 89 (70.6%) of the community pharmacists. However, 60 (47.6%) reported that antibiotics were not classified as prescription-only medications in Nigeria and that there were no regulations governing their sale and dispensing. Majority, 118 (93.7%), agreed that it is important to conduct culture and sensitivity tests before prescribing antibiotics to patients. Only 21 (16.7%) of the respondents agreed that pharmacists should always dispense antibiotics only when a prescription is presented. In all, 115 (91.3%) community pharmacists had poor antibiotic dispensing practices. Conclusion Most of the community pharmacists possess adequate knowledge of antibiotics and antibiotic resistance; nonetheless, a significant portion of them exhibits poor antibiotic dispensing practices.
摘要目的抗菌素耐药性是全球主要的健康威胁,抗生素的不当使用是这一现象的关键驱动因素。社区药剂师在负责任地使用抗生素和促进抗菌药物管理方面发挥着至关重要的作用。本研究评估了社区药剂师对抗生素和抗生素耐药性的知识和认知,以及他们的抗生素配药做法。方法采用自行填写的纸质问卷,对伊巴丹市126名社区药师进行横断面调查。问卷包括李克特式8项知识量表、5项知觉量表和18项配药实践量表。量表得分被分级为充分和不充分的知识,以及良好或不良的分配做法。数据分析使用SPSS(版本25),结果采用描述性统计。89名(70.6%)的社区药师对抗生素和抗生素耐药性有充分的了解。然而,60家(47.6%)报告说,抗生素在尼日利亚未被归类为仅供处方的药物,并且没有管理其销售和配药的法规。大多数(118人)(93.7%)认为在给患者开抗生素处方前进行培养和敏感性试验很重要。只有21人(16.7%)同意药剂师应始终只在出示处方时才配发抗生素。总共有115名(91.3%)社区药师抗生素配药操作不当。结论大部分社区药师对抗菌药物及耐药知识掌握较好;尽管如此,他们中的很大一部分表现出不良的抗生素分配做法。
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引用次数: 0
Designing supplements for stocker cattle grazing wheat pasture 小麦牧场放牧牛饲料的设计
Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-08-14 DOI: 10.1093/jphsr/rmad039
Pharmacy and pharmaceutical sciences embrace a series of different disciplines. Pharmacy practice has been defined as ‘the scientific discipline that studies the different aspects of the practice of pharmacy and its impact on health care systems, medicine use, and patient care’. Thus, pharmacy practice studies embrace both clinical pharmacy and social pharmacy elements. Like any other scientific discipline, clinical and social pharmacy practice disseminates research findings using scientific journals. Clinical pharmacy and social pharmacy journal editors have a role in promoting the discipline by enhancing the quality of the articles published. As has occurred in other healthcare areas (i.e. medicine and nursing), a group of clinical and social pharmacy practice journal editors gathered in Granada, Spain to discuss how journals could contribute to strengthening pharmacy practice as a discipline. The result of that meeting was compiled in these Granada Statements, which comprise 18 recommendations gathered into 6 topics, namely the appropriate use of terminology, impactful abstracts, the required peer reviews, journal scattering, more effective and wiser use of journal and article performance metrics and authors’ selection of the most appropriate pharmacy practice journal to submit their work.
药剂学和药理学包括一系列不同的学科。药学实践被定义为“研究药学实践的不同方面及其对卫生保健系统、药物使用和患者护理的影响的科学学科”。因此,药学实践研究包含临床药学和社会药学两个要素。像任何其他科学学科一样,临床和社会药学实践通过科学期刊传播研究成果。临床药学和社会药学期刊编辑通过提高发表文章的质量来促进该学科的发展。正如在其他医疗保健领域(即医学和护理)发生的那样,一组临床和社会药学实践期刊编辑聚集在西班牙格拉纳达,讨论期刊如何有助于加强药学实践作为一门学科。会议的结果汇编在这些格拉纳达声明中,其中包括18项建议,分为6个主题,即适当使用术语,有影响力的摘要,所需的同行评审,期刊分散,更有效和更明智地使用期刊和文章绩效指标,以及作者选择最合适的药学实践期刊来提交他们的工作。
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引用次数: 0
Reduced risk of mortality among COVID-19 patients with in-hospital selective serotonin reuptake inhibitor administration 院内选择性5 -羟色胺再摄取抑制剂治疗降低COVID-19患者死亡风险
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-07-17 DOI: 10.1093/jphsr/rmad031
Adam Hasse, Kimberly M. Korwek, R. Poland
The anti-inflammatory properties of selective serotonin reuptake inhibitors (SSRI)s, particularly fluvoxamine, have been hypothesized to reduce clinical deterioration in patients with COVID-19 when administered early in the disease course. The objective of this analysis was to examine the effect of maintenance SSRI administration, including variation among different medications, on the outcomes of hospitalized patients with COVID-19. Retrospective analysis of disease progression and mortality risk of over 230,000 patients hospitalized with COVID-19 at facilities associated with a large healthcare system in the United States. Receipt of SSRIs during the hospital encounter occurred in approximately 10.6% (n = 24,690) of COVID-19 patients. When matched for patient characteristics, disease severity and other treatments, receipt of any SSRI was associated with a 30% reduction in the relative risk of mortality (RR: 0.70, 95% confidence interval [CI]: 0.67–0.73; adjusted P-value <0.001). Similar reductions in the relative risk of mortality were seen with nearly every individual SSRI; for sertraline-treated patients, the most commonly used SSRI in the data set, there was a 29% reduction in the relative risk of mortality (RR: 0.71, 95% CI: 0.66–0.77; adjusted P-value <0.001). In total, this retrospective analysis suggests that there is a significant association between SSRI antidepressants and reduced morality among patients hospitalized with COVID-19.
选择性5-羟色胺再摄取抑制剂(SSRI)的抗炎特性,特别是氟伏沙明,被假设在病程早期服用可减少新冠肺炎患者的临床恶化。本分析的目的是检查维持SSRI给药对新冠肺炎住院患者结局的影响,包括不同药物之间的差异。对美国大型医疗系统相关设施中因新冠肺炎住院的23万多名患者的疾病进展和死亡率风险进行回顾性分析。约10.6%(n=24690)的新冠肺炎患者在住院期间接受SSRI。当与患者特征、疾病严重程度和其他治疗相匹配时,接受任何SSRI都与相对死亡率降低30%相关(RR:0.70,95%置信区间[CI]:0.67-0.73;调整后的P值<0.001)。几乎每个SSRI的相对死亡率都有类似的降低;对于舍曲林治疗的患者(数据集中最常用的SSRI),相对死亡率降低了29%(RR:0.71,95%CI:0.66–0.77;调整后的P值<0.001)。总之,这项回顾性分析表明,在新冠肺炎住院患者中,SSRI抗抑郁药与道德降低之间存在显著关联。
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引用次数: 0
Assessing drug utilization and drug–drug interactions in the management of epilepsy, Alzheimer’s, Parkinson’s disease and migraine 评估癫痫、阿尔茨海默氏症、帕金森氏症和偏头痛治疗中的药物利用和药物相互作用
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-07-01 DOI: 10.1093/jphsr/rmad034
N. Solanki, Ishita Champaneri, Varsha Patel
Neurological disorders (ND) affect the structure and function of the central nervous system, including Alzheimer’s and Parkinson’s diseases, epilepsy, migraine and stroke. ND has major symptoms ranging from mild to severe memory problems and physical disabilities. The present study investigated central nervous system (CNS) drug utilization trends, drug–drug interaction and morbidity patterns in ND. A prospective study was carried out at a multi-specialty hospital, including neurology outpatient cases, in 2016. A study was ethically approved by the institutional ethics committee (IEC) for human research, and data were collected from patients’ case records. The prescribing trend was assessed by World Health Organization (WHO) core prescribing indicators. The International Classification of Diseases (ICD) 10 was used to assess the morbidity pattern. Drug–drug interactions were analysed by a multidrug interaction checker. We discovered that 53.57% and 46.42% of the 280 neurology cases were female and male, respectively. Here, we showed that epilepsy was the most commonly diagnosed (31.07%) condition, followed by migraine (30.35%), Parkinsonism (Pn) (13.21%), Alzheimer’s and dementia (AD) (10.71%) and myasthenia gravis (7.14%). The most commonly used CNS drugs were sodium valproates. Donepezil, fluoxatin and levodopa–carbidopa. In this study, 80% of drugs were prescribed with the most common category being antiepileptics; 16.77% and 23.21% of prescriptions observed potential drug–drug interactions. The treatment priority for epilepsy was sodium valproate, which had a high prescription rate. For AD, donepezil was given priority, while in PN, levodopa–carbidopa was prescribed most often. In significant drug–drug interactions (DDI), pharmacodynamic mechanisms were very common, while in minor DDI, pharmacokinetic mechanisms were observed.
神经系统疾病(ND)影响中枢神经系统的结构和功能,包括阿尔茨海默病和帕金森病、癫痫、偏头痛和中风。ND的主要症状包括轻度到重度的记忆问题和身体残疾。本研究调查了ND的中枢神经系统(CNS)药物利用趋势、药物相互作用和发病模式。2016年,在一家多专科医院进行了一项前瞻性研究,包括神经科门诊病例。一项研究得到了机构伦理委员会(IEC)的伦理批准,用于人类研究,数据是从患者的病例记录中收集的。世界卫生组织(世界卫生组织)的核心处方指标对处方趋势进行了评估。国际疾病分类(ICD)10用于评估发病模式。药物-药物相互作用通过多药相互作用检查器进行分析。我们发现,在280例神经病学病例中,女性和男性分别占53.57%和46.42%。在这里,我们发现癫痫是最常见的诊断疾病(31.07%),其次是偏头痛(30.35%)、帕金森病(Pn)(13.21%)、阿尔茨海默病和痴呆症(AD)(10.71%)和重症肌无力(7.14%)。最常用的中枢神经系统药物是丙戊酸钠。多奈哌齐、氟沙汀和左旋多巴-卡比多巴。在这项研究中,80%的药物是处方药,最常见的类别是抗癫痫药物;16.77%和23.21%的处方观察到潜在的药物-药物相互作用。癫痫的治疗重点是丙戊酸钠,它的处方率很高。对于AD,多奈哌齐是优先考虑的,而对于PN,左旋多巴-卡比多巴是最常见的处方。在重要的药物-药物相互作用(DDI)中,药效学机制非常常见,而在次要的DDI中,观察到了药代动力学机制。
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引用次数: 1
The impact of online medication reviews and educational workshops on deprescribing during the COVID-19 pandemic: a controlled before-after study 在线药物评论和教育研讨会对新冠肺炎大流行期间取消描述的影响:一项前后对照研究
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-06-30 DOI: 10.1093/jphsr/rmad037
Lina Al-Sakran, Gregory Carney, M. Maclure, Anat Fisher, T. Perry, C. Dormuth
The South Peace Polypharmacy Reduction Project is a quality improvement project in three communities in rural Canada that aimed to reduce polypharmacy and inappropriate prescribing practices in older adults. This study aims to evaluate the impact of a multifaceted intervention consisting of online team-based medication reviews and educational workshops on the number of chronic medications. A controlled before-after design was used to compare if a decrease in the number of chronic medications was associated with the intervention comprising of online team-based medication reviews and educational workshops, compared with two matched control groups that received either a standard medication review or no medication review. Logistic regression models fit with generalized estimated equations were used to identify the impact of the interventions on decreasing the number of chronic medications. Following a medication review, the percentage of individuals that had deprescribed at least one medication was highest in the intervention group (52%), followed by the medication review controls at 45%, and 36% in non-medication review controls. Individuals in the intervention group were 20% more likely to have at least one medication deprescribed than individuals in the medication review control group (adjusted odds ratio: 1.20; 95% CI: 1.03 to 1.39), whereas they were 42% more likely to deprescribe at least one medication compared with non-medication review controls (adjusted odds ratio: 1.42; 95% CI: 1.25 to 1.61). Online team-based medication reviews had a significant impact on decreasing the number of chronic medications in older adults. Furthermore, providing healthcare providers with education can complement the role of other healthcare interventions.
南部和平减少多种药房项目是加拿大农村三个社区的质量改进项目,旨在减少老年人的多种药房和不当处方做法。本研究旨在评估多方面干预的影响,包括基于在线团队的药物评论和教育研讨会对慢性药物的数量。与接受标准药物评估或不接受药物评估的两个匹配对照组相比,采用控制的事前-事后设计来比较慢性药物数量的减少是否与由在线团队药物评估和教育研讨会组成的干预有关。采用Logistic回归模型拟合广义估计方程来确定干预措施对减少慢性药物数量的影响。在药物回顾后,干预组中至少开过一种药物的个体比例最高(52%),其次是药物回顾组(45%),非药物回顾组(36%)。干预组的个体比药物回顾对照组的个体至少有一种药物被开处方的可能性高20%(校正优势比:1.20;95% CI: 1.03 - 1.39),而与非药物审查对照组相比,他们至少取消一种药物的可能性高出42%(调整优势比:1.42;95% CI: 1.25 ~ 1.61)。基于在线团队的药物评估对减少老年人慢性药物的数量有显著的影响。此外,向卫生保健提供者提供教育可以补充其他卫生保健干预措施的作用。
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引用次数: 0
Satisfaction on educational training quality amongst college pharmacist alumni in Vietnam 越南大学药剂师校友对教育培训质量的满意度
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-06-28 DOI: 10.1093/jphsr/rmad036
Ba Kien Tran, Thi Huong Vu, D. T. Pham, D. T. Huynh, V. D. Tran
This study aimed to determine the factors affecting the satisfaction of 3-year-programme college pharmacy alumni on training/educational quality at a pharmacy college in Vietnam. A cross-sectional research using a purposive sampling method was conducted on the alumni who had recently graduated in 2020 of a pharmacy college in Hai Duong, Vietnam. Data collection was conducted in two phases from November 2021 to January 2022, with the first phase being an online survey through Google Forms and the second phase being phone interviews and the use of the Zalo application. The quality of educational training was evaluated using 21 items, with an additional item designated for overall satisfaction. Exploratory factor analysis identified the four factors from the 21 items assessing training quality, whereas multivariate regression analysis determined the relationship between satisfaction factors and the overall satisfaction. A total of 282 complete records were obtained. The college pharmacist alumni’s satisfaction with the training qualities is influenced by four main factors, with internal consistency assessed using Cronbach’s alpha (α): the training staff (α = 0.93), the facilities and environment qualities (α = 0.91), the training programmes (α = 0.88) and the administrative formalities and support activities (α = 0.84). All factors had a positive impact on alumni satisfaction, the training staff factor (β = 0.460, P < 0.001) had the greatest impact on the alumni satisfaction. This study identified four factors affecting the satisfaction of college pharmacy alumni on training quality, including (1) the training staff, (2) the facilities and environmental qualities, (3) the training programmes and (4) the administrative formalities and support activities. To enhance training quality and alumni satisfaction, educational institutions should focus on innovating the teaching methods of the faculty, shifting from traditional teaching methods to active teaching methods that make lectures dynamic and help students develop necessary skills, as well as organizing training sessions and practical visits to improve specialized knowledge and practical experience for the faculty.
本研究旨在确定影响越南一所药学学院3年制药学系校友对培训/教育质量满意度的因素。采用有目的的抽样方法,对2020年刚毕业于越南海阳一所药学院的校友进行了横断面研究。数据收集分两个阶段进行,从2021年11月到2022年1月,第一阶段是通过谷歌表格进行的在线调查,第二阶段是电话采访和Zalo应用程序的使用。教育培训的质量使用21个项目进行评估,另外一个项目指定为总体满意度。探索性因素分析从评估训练质量的21个项目中确定了四个因素,而多元回归分析确定了满意度因素与总体满意度之间的关系。共获得282份完整记录。大学药剂师校友对培训质量的满意度受四个主要因素的影响,内部一致性采用Cronbachα(α)进行评估:培训人员(α=0.93)、设施和环境质量(α=0.91),培训计划(α=0.88)和行政手续及支持活动(α=0.84)。所有因素对校友满意度都有积极影响,培训人员因素(β=0.460,P<0.001)对校友满意度的影响最大。本研究确定了四个影响大学药学校友对培训质量满意度的因素,包括(1)培训人员,(2)设施和环境质量,(3)培训计划和(4)行政手续和支持活动。为了提高培训质量和校友满意度,教育机构应专注于创新教师的教学方法,从传统的教学方法转变为积极的教学方式,使讲座充满活力,帮助学生发展必要的技能,以及组织培训课程和实践访问,以提高教师的专业知识和实践经验。
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引用次数: 0
How structural changes are driving R&D activity in India’s pharmaceutical sector 结构变化如何推动印度制药行业的研发活动
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-06-13 DOI: 10.1093/jphsr/rmad035
Niloufer Sohrabji, Kristen Marquette
Rising Research and Development (R&D) activity has led to dramatic growth in India’s pharmaceutical market in the last decade. This increase in R&D was occurring at a time of significant changes in the sector, notably in the intellectual property rights (IPR) system and the sector’s increased focus on biopharmaceuticals. The objective of this study is to examine the impact of these structural changes along with the traditional drivers of R&D activity to better understand the transformation in India’s pharmaceutical sector during this period and shed light on its future trajectory. We extend the traditional model to estimate the determinants of R&D by incorporating the changes in India’s pharmaceutical sector during this period. With pooled data for the top 16 pharmaceutical firms during the last decade, this model is estimated using feasible generalised least squares. Our results show that R&D is affected by firm size, global reach, and profitability. Experience, particularly successful patent experience, is important. However, at some point, R&D activity resulting from longevity succumbs to diminishing returns. Also, the IPR environment and firm investment in biopharmaceutical treatment are important drivers of R&D. Promoting R&D activity is vital to keep India’s pharmaceutical sector on its growth trajectory. Policies supporting the sector’s shift from imitation to innovation and promotion of biopharmaceutical treatment will ensure its continued success.
在过去十年中,不断增长的研发活动导致了印度制药市场的急剧增长。研发的增加发生在该行业发生重大变化之际,尤其是在知识产权体系和该行业越来越关注生物制药方面。本研究的目的是检验这些结构变化的影响以及研发活动的传统驱动因素,以更好地了解这一时期印度制药行业的转型,并阐明其未来轨迹。我们扩展了传统模型,通过纳入这一时期印度制药行业的变化来估计研发的决定因素。根据过去十年中排名前16的制药公司的汇总数据,该模型是使用可行的广义最小二乘法进行估计的。我们的研究结果表明,研发受到企业规模、全球影响力和盈利能力的影响。经验,特别是成功的专利经验是很重要的。然而,在某种程度上,寿命带来的研发活动会屈服于回报递减。此外,知识产权环境和企业对生物制药治疗的投资是研发的重要驱动力。促进研发活动对于保持印度制药行业的增长轨迹至关重要。支持该行业从模仿转向创新和推广生物制药治疗的政策将确保其持续成功。
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引用次数: 0
A study assessing public knowledge and behaviour of antibiotic use in Abu Dhabi and Dubai 一项评估阿布扎比和迪拜公众抗生素使用知识和行为的研究
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-06-07 DOI: 10.1093/jphsr/rmad033
L. M. Mohammad, Rana Mahmood Kamran, S. Gillani
The inappropriate use of antibiotics is one of the main factors in the development of antibiotic resistance. This study aimed at examining the public’s knowledge and behaviour in Abu Dhabi and Dubai towards antibiotic use. A cross-sectional survey was performed using a pretested self-administered online questionnaire on a sample of 208 randomly selected from Abu Dhabi and Dubai residents. Descriptive statistics and P values were used in data analysis. In our population, 63% knew that antibiotic usage is ineffective in treating viral infections. Half of our participants were unsure or misinformed that antibiotics could treat the common cold. On the other hand, 93% knew that the body can fight mild infections without antibiotics. The results also showed that almost 29% take antibiotics for pain and inflammation. Approximately, 72% of the population denied consuming leftover antibiotics. Also, 95.2% of the population confirmed they check the expiry date before using antibiotics, and 82.7% stop the antibiotic after completing the course prescribed by a physician. This study revealed the gaps in knowledge and practice towards antibiotics among the general population. It also identified areas that need more interventions to promote the rational use of antibiotics, and thus reduce the risk of development of antibiotic resistance.
抗生素的不当使用是抗生素耐药性发展的主要因素之一。这项研究旨在检验阿布扎比和迪拜公众对抗生素使用的知识和行为。一项横断面调查使用了一份预测试的自我管理在线问卷,从阿布扎比和迪拜居民中随机抽取208名样本。数据分析采用描述性统计和P值。在我们的人群中,63%的人知道抗生素的使用对治疗病毒感染无效。我们一半的参与者不确定或错误地认为抗生素可以治疗普通感冒。另一方面,93%的人知道,在没有抗生素的情况下,身体可以对抗轻度感染。研究结果还显示,近29%的人服用抗生素治疗疼痛和炎症。大约72%的人口否认食用剩余的抗生素。此外,95.2%的人群确认他们在使用抗生素前检查了有效期,82.7%的人在完成医生开具的疗程后停止使用抗生素。这项研究揭示了普通人群在抗生素知识和实践方面的差距。它还确定了需要更多干预措施的领域,以促进抗生素的合理使用,从而降低抗生素耐药性的风险。
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引用次数: 0
The impact of pharmacist-guided inhaler technique education on chronic obstructive pulmonary disease and asthma patients 药师指导下吸入器技术教育对慢性阻塞性肺疾病及哮喘患者的影响
IF 0.7 Q2 Pharmacology, Toxicology and Pharmaceutics Pub Date : 2023-05-11 DOI: 10.1093/jphsr/rmad032
J. Cohen, Iris Rosenbaum, B. Oberman, Irit Katz, Naama Sharabi, D. Shlomi
The core treatment for asthma and chronic obstructive pulmonary disease (COPD) is inhalers. Today, there are many types of pressurized metered-dose inhalers (pMDIs) and dry powdered inhalers (DPIs). Each inhaler requires special sequential manoeuvres and coordination. It is well-known from previous studies that most patients perform at least one mistake using their inhaler which may lead to ineffective drug delivery and poor disease control. The aim of this study is to measure the proportion of patients who used the inhalers in a fully effective way before and after the pharmacist’s guidance. Patients prescribed inhalers for asthma and COPD, were offered by the local pharmacist to personally assess and correct their inhaler use technique over two visits. At each visit, before any pharmacist correction of technique, a general score for inhaler technique was given and 16 types of mistakes were assessed. Comparisons of inhaler technique were made between the two visits. Sixty patients aged 21–91 (median 69; IQR 48–78) participated in the initial session of which 35 (58%) were females using 81 inhalers (DPI-60, pMDI-21). A fully effective inhaler technique was found in nine patients (15%) using 13 inhalers (16%) while 22 inhalers (27%) were used fully ineffectively (there were no statistically significant differences between DPIs and pMDIs). Twenty-three patients using 24 inhalers returned for a second visit in which 12 patients (52%, P = 0.0014 between the visits) used 12 inhalers (50%) fully effectively and only three inhalers (12.5%) were used fully ineffectively (P = 0.0045 between the visits). The odds for using the inhaler fully effectively were 5.2 (95% CI, 1.9 to 14.2; P = 0.0011) times higher on the second visit. Personal pharmacist guidance can improve inhaler technique in a low socio-economic neighbourhood. However, larger multicentre studies that will also examine clinical outcomes are needed.
哮喘和慢性阻塞性肺病(COPD)的核心治疗方法是吸入器。如今,有许多类型的加压计量吸入器(pMDI)和干粉吸入器(DPI)。每个吸入器都需要特殊的顺序操作和协调。从以前的研究中可以看出,大多数患者在使用吸入器时至少犯了一个错误,这可能导致药物输送无效和疾病控制不力。本研究的目的是测量在药剂师指导前后以完全有效的方式使用吸入器的患者比例。当地药剂师为哮喘和慢性阻塞性肺病患者开了吸入器,让他们在两次就诊中亲自评估和纠正他们的吸入器使用技术。在每次就诊时,在药剂师对技术进行任何纠正之前,对吸入器技术进行一般评分,并评估16种类型的错误。对两次访问的吸入器技术进行了比较。60名年龄在21-91岁(中位数69;IQR 48-78)的患者参加了最初的治疗,其中35名(58%)为女性,使用81种吸入器(DPI-60,pMDI-21)。在9名患者(15%)中发现了一种完全有效的吸入器技术,使用了13种吸入器(16%),而22种吸入器的使用完全无效(DPI和pMDI之间没有统计学上的显著差异)。23名使用24个吸入器的患者返回第二次就诊,其中12名患者(52%,两次就诊之间P=0.0014)完全有效地使用了12个吸入器(50%),只有3名吸入器(12.5%)完全无效地使用(两次就诊间P=0.0045)。第二次就诊时,完全有效使用吸入器的几率高5.2倍(95%置信区间,1.9至14.2;P=0.0011)。个人药剂师指导可以改善低社会经济水平地区的吸入器技术。然而,还需要更大规模的多中心研究来检查临床结果。
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引用次数: 0
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Journal of Pharmaceutical Health Services Research
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