Nanostructured fertilizers or nano-fertilizers are in the form of nanocarriers, nanocapsules or nanonutrients that should be considered as smart fertilizers that can improve plant nutrient utilization efficiency, control nutrient release and reduce environmental impact. However, there is an urgent need to standardize and evaluate the toxicity of nanomaterials used in the synthesis of nano-fertilizers. Therefore, detailed agricultural field and greenhouse surveys are highly recommended for performance evaluation of nano-fertilizers.
{"title":"Nano-Fertilizers - A Cutting Edge Approach for Sustainable Agriculture","authors":"","doi":"10.33140/jpr.06.02.02","DOIUrl":"https://doi.org/10.33140/jpr.06.02.02","url":null,"abstract":"Nanostructured fertilizers or nano-fertilizers are in the form of nanocarriers, nanocapsules or nanonutrients that should be considered as smart fertilizers that can improve plant nutrient utilization efficiency, control nutrient release and reduce environmental impact. However, there is an urgent need to standardize and evaluate the toxicity of nanomaterials used in the synthesis of nano-fertilizers. Therefore, detailed agricultural field and greenhouse surveys are highly recommended for performance evaluation of nano-fertilizers.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48189796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Appropriate chemical and/or mechanical venous thromboembolism prophylaxis is a high priority for clinicians. Unfortunately, there is little evidence-based guidance for clinical decision making for patients requiring both renal replacement therapy and VTE prophylaxis. The package insert for unfractionated heparin recommends 5000 units subcutaneously every 8 to 12 hours for VTE prophylaxis. Objective: The purpose of this study was to assess the two recommended dosing intervals and determine if there is a difference in terms of incidence of clotting or bleeding events. Methods: 159 patients were admitted to the UNC Health Care system between March 2014 and November 2019 and retrospectively screened for incidence of both the primary composite efficacy outcome (symptomatic or asymptomatic vascular event (VTE [DVT and PE]), ischemic event (stroke, TIA, or myocardial infarction), or death related to coagulopathy), the individual components of the composite outcome and the primary safety outcome. The results of the outcomes were then compared and analyzed using Fischer’s Exact test. Results: The two tailed p-values of the primary composite efficacy outcome (0.3517), the primary safety outcome (0.1571) and each of the composite outcomes (0.1556, 1.0000, 0.2297, respectively) showed no statistically significant difference. Conclusion: Results of this study show that there is no statistical difference between the dosing intervals of prophylactic UFH of every 8 to 12 hours, in terms of the incidence of VTE and major bleed events, for patients requiring CRRT. Suggesting that either interval is both efficacious and safe for the use of VTE prophylaxis.
{"title":"Retrospective Study of Venous Thromboembolism Prophylaxis Dosing of Heparin in Adult Patients receiving Continuous Renal Replacement Therapy","authors":"","doi":"10.33140/jpr.06.02.04","DOIUrl":"https://doi.org/10.33140/jpr.06.02.04","url":null,"abstract":"Background: Appropriate chemical and/or mechanical venous thromboembolism prophylaxis is a high priority for clinicians. Unfortunately, there is little evidence-based guidance for clinical decision making for patients requiring both renal replacement therapy and VTE prophylaxis. The package insert for unfractionated heparin recommends 5000 units subcutaneously every 8 to 12 hours for VTE prophylaxis. Objective: The purpose of this study was to assess the two recommended dosing intervals and determine if there is a difference in terms of incidence of clotting or bleeding events. Methods: 159 patients were admitted to the UNC Health Care system between March 2014 and November 2019 and retrospectively screened for incidence of both the primary composite efficacy outcome (symptomatic or asymptomatic vascular event (VTE [DVT and PE]), ischemic event (stroke, TIA, or myocardial infarction), or death related to coagulopathy), the individual components of the composite outcome and the primary safety outcome. The results of the outcomes were then compared and analyzed using Fischer’s Exact test. Results: The two tailed p-values of the primary composite efficacy outcome (0.3517), the primary safety outcome (0.1571) and each of the composite outcomes (0.1556, 1.0000, 0.2297, respectively) showed no statistically significant difference. Conclusion: Results of this study show that there is no statistical difference between the dosing intervals of prophylactic UFH of every 8 to 12 hours, in terms of the incidence of VTE and major bleed events, for patients requiring CRRT. Suggesting that either interval is both efficacious and safe for the use of VTE prophylaxis.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47475569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension is one of the most common Non-Communicable Diseases, which is increasing day by day, and its complications account for 9.4 million annual deaths worldwide. The rate of hypertension in Chattogram is relatively higher and majority are undiagnosed hypertension. This study was conducted to investigate the risk factors of hypertension on the population of Chattogram and to determine the complication of Hypertension. This survey study was carried out from June 2019 to December 2019. From the survey, it was found that about 49% of people have hypertension in age between 20-49, 43% people have in age between 50-79, about 12% people have in age above 80, and majority of population have hypertension in age between 20-49. Among them, about 46% of male are suffered fromhypertension whereasfemale are 57%. Hence, the risk of hypertension is higherin female rather than in male. About 50% of people have systolic blood pressure range above 130, 38% people have above 160, 10 people have above 180 & 6% people have above 100. About 44% of people have blood relative with hypertension, about 35% people do not have & about 24% people do not aware of the relative with hypertension. Among them about 21% people are given metformin for the treatment of diabetes mellitus in hypertension & about 10% people are given both metformin & glibenclamide. About 54% of people are given Enalapril, 33% people are given Amlodipine, 7% people are given both enalapril & Amlodipine and 5% people are given hydrochlorothiazide. Compliance with treatment was relatively high; however, accessessibilty of drugs was mainly from private pharmacies. Hypertension was significantly associated with increasing age, being male, unemployment and obesity.
{"title":"Evaluation of Present Status of Hypertension at Port City Chattogram, Bangladesh: A Survey Study","authors":"","doi":"10.33140/jpr.06.02.05","DOIUrl":"https://doi.org/10.33140/jpr.06.02.05","url":null,"abstract":"Hypertension is one of the most common Non-Communicable Diseases, which is increasing day by day, and its complications account for 9.4 million annual deaths worldwide. The rate of hypertension in Chattogram is relatively higher and majority are undiagnosed hypertension. This study was conducted to investigate the risk factors of hypertension on the population of Chattogram and to determine the complication of Hypertension. This survey study was carried out from June 2019 to December 2019. From the survey, it was found that about 49% of people have hypertension in age between 20-49, 43% people have in age between 50-79, about 12% people have in age above 80, and majority of population have hypertension in age between 20-49. Among them, about 46% of male are suffered fromhypertension whereasfemale are 57%. Hence, the risk of hypertension is higherin female rather than in male. About 50% of people have systolic blood pressure range above 130, 38% people have above 160, 10 people have above 180 & 6% people have above 100. About 44% of people have blood relative with hypertension, about 35% people do not have & about 24% people do not aware of the relative with hypertension. Among them about 21% people are given metformin for the treatment of diabetes mellitus in hypertension & about 10% people are given both metformin & glibenclamide. About 54% of people are given Enalapril, 33% people are given Amlodipine, 7% people are given both enalapril & Amlodipine and 5% people are given hydrochlorothiazide. Compliance with treatment was relatively high; however, accessessibilty of drugs was mainly from private pharmacies. Hypertension was significantly associated with increasing age, being male, unemployment and obesity.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48301315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Stroke is neurovascular disease caused by disruption of blood flow to brain, result in neurological deficit. As a consequence of stroke there will be loss of leg strength and impaired balance that may affect walking ability. Gait parameters are also affected as a consequences of stroke. Overall affection of gait parameters and balance will affect Quality of Life. Objective: The study is conducted to find out relationship between Gait parameters, Balance and Quality of Life in recovering stroke patients- A Correlation Study” Material and Methodology: Total 32 patients were screened as per inclusion and exclusion criteria. Demographic data was taken. At the time of discharge from the hospital Health status was assessed with use of stroke Impact scale. TUG was taken to measure the Balance. Gait velocity was calculated by use of 6 minute walk test. Result: Total 32 Recovering stroke Patients have participated in the study. All the stroke patients who have participated in the study were having mean age of 52.65 years and participants of both the genders were included. Amongst the participants’ males were 78.21% and females were 21.9%. Were included in the study. Participants with both sided strokes were consider for data collection. Stroke impact scale score has found to have positive correlation with Gait velocity, and stride length, and negative correlation with TUG. (P = .001 to P = .031). TUG score correlated negatively with Gait Velocity and Stride Length. Conclusion: Gait parameters have impact on Quality of Life have but will not produce much difference on balance. There is no significant influence of gait parameters on Balance.
{"title":"Effect of Gait Parameters On Balance and Quality of Life in Recovering Stroke Patients- A Correlation Study","authors":"","doi":"10.33140/jpr.06.02.03","DOIUrl":"https://doi.org/10.33140/jpr.06.02.03","url":null,"abstract":"Introduction: Stroke is neurovascular disease caused by disruption of blood flow to brain, result in neurological deficit. As a consequence of stroke there will be loss of leg strength and impaired balance that may affect walking ability. Gait parameters are also affected as a consequences of stroke. Overall affection of gait parameters and balance will affect Quality of Life. Objective: The study is conducted to find out relationship between Gait parameters, Balance and Quality of Life in recovering stroke patients- A Correlation Study” Material and Methodology: Total 32 patients were screened as per inclusion and exclusion criteria. Demographic data was taken. At the time of discharge from the hospital Health status was assessed with use of stroke Impact scale. TUG was taken to measure the Balance. Gait velocity was calculated by use of 6 minute walk test. Result: Total 32 Recovering stroke Patients have participated in the study. All the stroke patients who have participated in the study were having mean age of 52.65 years and participants of both the genders were included. Amongst the participants’ males were 78.21% and females were 21.9%. Were included in the study. Participants with both sided strokes were consider for data collection. Stroke impact scale score has found to have positive correlation with Gait velocity, and stride length, and negative correlation with TUG. (P = .001 to P = .031). TUG score correlated negatively with Gait Velocity and Stride Length. Conclusion: Gait parameters have impact on Quality of Life have but will not produce much difference on balance. There is no significant influence of gait parameters on Balance.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41550253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-16DOI: 10.9734/JPRI/2021/V33I32A31711
Vairakkannu Sivasakthi, K. Selvam, S. Loganathan, P. Prakash
Objective: Current scientific investigations have evidenced that there is increased attention in developing novel drugs from bio source for the human health concern. This study's main objective was to intervene phytochemical constituents present in the ethanol leaf extract of an aromatic plant, Ixora brachiata (Roxb) and to evaluate their ability on antioxidant, anticancer and larvicidal properties, using invitro models. Methods: Antioxidant assay was performed by scavenging behaviour of DPPH, ABTS, H2 O2 and Reducing power screenings. The phytochemical composition was also screened using GC-MS technique. Cytotoxicity effect was determined by employing MTT Assay, the larvicidal potential was predicted by following the protocol described by WHO. In phytochemical screening higher concentration of alkaloids, flavonoids, phenolic and diterpenoids were detected in significant content. Geranyl linalool was the profound compound present, and it has been reported, used in various treatments for cancer ailments, similar to Taxol. Results: The cytotoxicity values of ethanol extract were found to be 11.57 to 55.95% against the cancer cells (A549) and 12.36-63.8% range was observed against HeLa cancers cell line. Larvicidal effects of the extract showed minimum LC50 value 14.69mg/ml against Aedes aegypti and 10.43mg/ml was recorded, against Culex quinquefasciatus, indicating, a promising capability of larvicidal action against mosquito larvae. Original Research Article Sivasakthi et al.; JPRI, 33(32A): 1-13, 2021; Article no.JPRI.68621 2 Conclusions: This study envisaged that ethanol extracts of I.brachiata are a bright and capable therapeutic agent, to combat in the battle of life threatened diseases, and infectious emerging threats.
{"title":"Pharmacological and Phytochemical Evaluation of Ethonalic Extract of Ixora brachiata (Roxb) Leaves","authors":"Vairakkannu Sivasakthi, K. Selvam, S. Loganathan, P. Prakash","doi":"10.9734/JPRI/2021/V33I32A31711","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I32A31711","url":null,"abstract":"Objective: Current scientific investigations have evidenced that there is increased attention in developing novel drugs from bio source for the human health concern. This study's main objective was to intervene phytochemical constituents present in the ethanol leaf extract of an aromatic plant, Ixora brachiata (Roxb) and to evaluate their ability on antioxidant, anticancer and larvicidal properties, using invitro models. Methods: Antioxidant assay was performed by scavenging behaviour of DPPH, ABTS, H2 O2 and Reducing power screenings. The phytochemical composition was also screened using GC-MS technique. Cytotoxicity effect was determined by employing MTT Assay, the larvicidal potential was predicted by following the protocol described by WHO. In phytochemical screening higher concentration of alkaloids, flavonoids, phenolic and diterpenoids were detected in significant content. Geranyl linalool was the profound compound present, and it has been reported, used in various treatments for cancer ailments, similar to Taxol. Results: The cytotoxicity values of ethanol extract were found to be 11.57 to 55.95% against the cancer cells (A549) and 12.36-63.8% range was observed against HeLa cancers cell line. Larvicidal effects of the extract showed minimum LC50 value 14.69mg/ml against Aedes aegypti and 10.43mg/ml was recorded, against Culex quinquefasciatus, indicating, a promising capability of larvicidal action against mosquito larvae. Original Research Article Sivasakthi et al.; JPRI, 33(32A): 1-13, 2021; Article no.JPRI.68621 2 Conclusions: This study envisaged that ethanol extracts of I.brachiata are a bright and capable therapeutic agent, to combat in the battle of life threatened diseases, and infectious emerging threats.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42997160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-16DOI: 10.9734/JPRI/2021/V33I32A31712
M. Kandeil, Sana’a O. Ebrahim, B. Mahmoud
Aims: Rheumatoid arthritis (RA) is characterized by the onset of oxidative stress. This study aimed to evaluate the enhancing of extra virgin olive (EVOO) and Evening primrose oil (EPO) on oxidative stress and liver enzymes in male Wistar rats and compare between them. Place and Duration: Faculty of Science biochemistry department, Between July 2018 and August 2018. Methodology: A Subcutaneous injection of 200 μl of Freund's complete adjuvant into a footpad of the right hind leg of Wistar male rats at two consecutive days induced RA. Rats received EVOO and EPO daily by oral gavage needle with gauge 18 at doses of 5 mg/kg b.wt./day. for 10 and 21 days. No loss was recorded in the experimental rats. Results: A significant depletion in serum Reduced glutathione content (GSH), glutathione Original Research Article Kandeil et al.; JPRI, 33(32A): 14-26, 2021; Article no.JPRI.69730 15 peroxidase (GPX), and glutathione s transferase activities (GST) in arthritic rats compared to normal rats after 10 and 21 days of induction which improved significantly after 10 and 21 days of EPO and EVOO treatments. EPO and EVOO treatments for 21 days increased the GSH and GPX compared to 10 days treatments while no difference in GST activity. EVOO treatment improved GSH and GPX after 10 and 21 days than EPO treatment. The elevated uric acid levels in arthritic rats were markedly ameliorated as a result of EVOO and EPO treatment administration. Increased lipid peroxidation products (MDA), rheumatoid factor, and liver enzyme (Alanine transaminase ALT and Aspartate transaminase AST) were recorded in arthritic rats and they significantly progressed after EPO and EVOO treatments for 10 and 21 days but EVOO had the best effect at 21 days. Conclusion: EVOO and EPO showed significant antioxidant efficacies and improved affected liver enzymes due to rheumatoid arthritis onset. When comparing olive oil has more antioxidant properties than evening primrose oil, so we recommend more studies on olive oil combination with anti-arthritic medications to improve their efficacies with less toxicity.
{"title":"The Enhanced Beneficial Effect of Extra Virgin Olive Oil Over Evening Primrose Oil on Oxidative Stress, and Liver Function in Male Arthritic Rats","authors":"M. Kandeil, Sana’a O. Ebrahim, B. Mahmoud","doi":"10.9734/JPRI/2021/V33I32A31712","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I32A31712","url":null,"abstract":"Aims: Rheumatoid arthritis (RA) is characterized by the onset of oxidative stress. This study aimed to evaluate the enhancing of extra virgin olive (EVOO) and Evening primrose oil (EPO) on oxidative stress and liver enzymes in male Wistar rats and compare between them. Place and Duration: Faculty of Science biochemistry department, Between July 2018 and August 2018. Methodology: A Subcutaneous injection of 200 μl of Freund's complete adjuvant into a footpad of the right hind leg of Wistar male rats at two consecutive days induced RA. Rats received EVOO and EPO daily by oral gavage needle with gauge 18 at doses of 5 mg/kg b.wt./day. for 10 and 21 days. No loss was recorded in the experimental rats. Results: A significant depletion in serum Reduced glutathione content (GSH), glutathione Original Research Article Kandeil et al.; JPRI, 33(32A): 14-26, 2021; Article no.JPRI.69730 15 peroxidase (GPX), and glutathione s transferase activities (GST) in arthritic rats compared to normal rats after 10 and 21 days of induction which improved significantly after 10 and 21 days of EPO and EVOO treatments. EPO and EVOO treatments for 21 days increased the GSH and GPX compared to 10 days treatments while no difference in GST activity. EVOO treatment improved GSH and GPX after 10 and 21 days than EPO treatment. The elevated uric acid levels in arthritic rats were markedly ameliorated as a result of EVOO and EPO treatment administration. Increased lipid peroxidation products (MDA), rheumatoid factor, and liver enzyme (Alanine transaminase ALT and Aspartate transaminase AST) were recorded in arthritic rats and they significantly progressed after EPO and EVOO treatments for 10 and 21 days but EVOO had the best effect at 21 days. Conclusion: EVOO and EPO showed significant antioxidant efficacies and improved affected liver enzymes due to rheumatoid arthritis onset. When comparing olive oil has more antioxidant properties than evening primrose oil, so we recommend more studies on olive oil combination with anti-arthritic medications to improve their efficacies with less toxicity.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43459343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-16DOI: 10.9734/JPRI/2021/V33I32A31713
Rekha Phull, V. Deshpande, Gaurav Phull
Dyslipidaemia an ever increasing menace emerging out of present lifestyle, is one of the major risk factors for developing Cardio-vascular abnormalities like Coronary Artery Disease (CAD), Myocardial infarction (MI), Cardiac arrest and is often associated with other metabolic disorders. Clinicians across the globe are trying hard to combat it. We have presented a Scientometric analysis of dyslipidaemia which includes Ayurvedic perspective also. Objective: In this study we intended to study detailed Scientometric and Bibliometric study on dyslipidaemia literature. Materials and methods: The data was collected using databases of Sciencedirect and Scopus, using the keywords ‘Dyslipidaemia’, ‘Dyslipidaemia in Ayurveda’, ‘Dyslipidaemia in India’,‘Medoroga in Ayurveda’ and ‘Medoraga in India’. Review Article Phull et al.; JPRI, 33(32A): 27-37, 2021; Article no.JPRI.69687 28 Results: A total of 85,500 items were retrieved from ‘science direct’ website, where majority of them were research articles and maximum publications were from the last decade indicating the recent enhancement in prevalence and awareness. A volley of research papers have come up with multiple approaches which include modern pharmacological measures, Ayurveda remedies and other herbal medicines along with non-pharmacological approaches like Yoga and Pranayama. Newer therapeutic agents like Ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies, PCSK9 small interference RNA (siRNA), and bempedoic acid, when added to the commonly used statin therapy have shown additional improvement to CV outcomes. Recent advances have come up with hepatocyte-specific targeting modifications and have shown promising lipid lowering effects. Conclusion: Our study was probably the first such kind of work in field of dyslipidaemia which includes publications related to Ayurveda and other herbal remedies also. It shows the ever rising trends in the publications related to dyslipidaemia and its relation to other metabolic disorders in recent years. The major concern is the progression in cases of dyslipidaemia and its cardiovascular outcomes despite of having substantial research work and awareness in different streams of medicine. We must focus on the multifactorial approach encouraging behavioural, dietary and pharmacological control of cholesterol and sensitize the masses about its serious consequences. A cumulative approach including modern advances with much safer herbal remedies and practice of Yogasana and Pranayama is the need of hour and may probably bring the best solution.
{"title":"Scientometric Study on Dyslipidaemia","authors":"Rekha Phull, V. Deshpande, Gaurav Phull","doi":"10.9734/JPRI/2021/V33I32A31713","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I32A31713","url":null,"abstract":"Dyslipidaemia an ever increasing menace emerging out of present lifestyle, is one of the major risk factors for developing Cardio-vascular abnormalities like Coronary Artery Disease (CAD), Myocardial infarction (MI), Cardiac arrest and is often associated with other metabolic disorders. Clinicians across the globe are trying hard to combat it. We have presented a Scientometric analysis of dyslipidaemia which includes Ayurvedic perspective also. Objective: In this study we intended to study detailed Scientometric and Bibliometric study on dyslipidaemia literature. Materials and methods: The data was collected using databases of Sciencedirect and Scopus, using the keywords ‘Dyslipidaemia’, ‘Dyslipidaemia in Ayurveda’, ‘Dyslipidaemia in India’,‘Medoroga in Ayurveda’ and ‘Medoraga in India’. Review Article Phull et al.; JPRI, 33(32A): 27-37, 2021; Article no.JPRI.69687 28 Results: A total of 85,500 items were retrieved from ‘science direct’ website, where majority of them were research articles and maximum publications were from the last decade indicating the recent enhancement in prevalence and awareness. A volley of research papers have come up with multiple approaches which include modern pharmacological measures, Ayurveda remedies and other herbal medicines along with non-pharmacological approaches like Yoga and Pranayama. Newer therapeutic agents like Ezetimibe, proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies, PCSK9 small interference RNA (siRNA), and bempedoic acid, when added to the commonly used statin therapy have shown additional improvement to CV outcomes. Recent advances have come up with hepatocyte-specific targeting modifications and have shown promising lipid lowering effects. Conclusion: Our study was probably the first such kind of work in field of dyslipidaemia which includes publications related to Ayurveda and other herbal remedies also. It shows the ever rising trends in the publications related to dyslipidaemia and its relation to other metabolic disorders in recent years. The major concern is the progression in cases of dyslipidaemia and its cardiovascular outcomes despite of having substantial research work and awareness in different streams of medicine. We must focus on the multifactorial approach encouraging behavioural, dietary and pharmacological control of cholesterol and sensitize the masses about its serious consequences. A cumulative approach including modern advances with much safer herbal remedies and practice of Yogasana and Pranayama is the need of hour and may probably bring the best solution.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":" ","pages":"27-37"},"PeriodicalIF":0.0,"publicationDate":"2021-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42416400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31694
A. Mueed, Nandlal Rathi, Shahzad, Jibran Ashraf, S. Ahmed, L. Rai
Objective: Supraventricular tachycardia (SVT) is the most common presentation of patients at cardiac emergency department. This study aims to determine the quality of life in patients with supraventricular tachycardia after they treated with medicines vs. ablation therapy. Methods: This prospective clinical comparative study was held at the National Institute of Cardiovascular Diseases (NICVD). Patients 18 years or older of either gender presenting with the two most common variants of SVT i.e. Atrioventricular nodal reentry tachycardia (AVNRT) and Atrioventricular reentry tachycardia (AVRT) were eligible to be included into the study. Once stabilized at the emergency department (ED) the patients were given the option to undergo electrophysiology study and radiofrequency ablation (EPS and RFA) (group A) or opt for medications only (group B). Quality of life (sense of personal well being, impact on social life, fear of mortality or anxiety about the disease, recurrence of episodes of arrhythmia, and visits to ED) was assessed through a questionnaire filled after six months of receiving treatment. Results: A total of 120 patients were included into our study. Group A and group B were evenly divided with 60 patients each. The overall mean age of the participants and duration of cardiac illness were 44.67±18.91 and 5.42±3.13 years, respectively. Patients who received EPS and RFA (group A) had superior and statistically significant scores (better QoL) for sense of personal well being, impact on social life, fear of mortality or anxiety levels, recurrence of arrhythmia, and visits to the ED as compared to those who received medications alone, p<0.05. Conclusion: EPS and RFA vastly improved the quality of life in patients with SVT post treatment. Medications alone are associated with a high number of post treatment sequels and adverse events; therefore they are best avoided in patients with SVT.
{"title":"Quality of Life after Ablation vs Medication Therapy in Patients With Supraventricular Tachycardia","authors":"A. Mueed, Nandlal Rathi, Shahzad, Jibran Ashraf, S. Ahmed, L. Rai","doi":"10.9734/JPRI/2021/V33I31B31694","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31694","url":null,"abstract":"Objective: Supraventricular tachycardia (SVT) is the most common presentation of patients at cardiac emergency department. This study aims to determine the quality of life in patients with supraventricular tachycardia after they treated with medicines vs. ablation therapy. \u0000Methods: This prospective clinical comparative study was held at the National Institute of Cardiovascular Diseases (NICVD). Patients 18 years or older of either gender presenting with the two most common variants of SVT i.e. Atrioventricular nodal reentry tachycardia (AVNRT) and Atrioventricular reentry tachycardia (AVRT) were eligible to be included into the study. Once stabilized at the emergency department (ED) the patients were given the option to undergo electrophysiology study and radiofrequency ablation (EPS and RFA) (group A) or opt for medications only (group B). Quality of life (sense of personal well being, impact on social life, fear of mortality or anxiety about the disease, recurrence of episodes of arrhythmia, and visits to ED) was assessed through a questionnaire filled after six months of receiving treatment. \u0000Results: A total of 120 patients were included into our study. Group A and group B were evenly divided with 60 patients each. The overall mean age of the participants and duration of cardiac illness were 44.67±18.91 and 5.42±3.13 years, respectively. Patients who received EPS and RFA (group A) had superior and statistically significant scores (better QoL) for sense of personal well being, impact on social life, fear of mortality or anxiety levels, recurrence of arrhythmia, and visits to the ED as compared to those who received medications alone, p<0.05. \u0000Conclusion: EPS and RFA vastly improved the quality of life in patients with SVT post treatment. Medications alone are associated with a high number of post treatment sequels and adverse events; therefore they are best avoided in patients with SVT.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"86-93"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46111219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31690
Meghana Satpute, B. Rathi, A. Wanjari, Mujahid B. Khan
Background: Praval (coral) is a very usually occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two formulas which are bhasma (calcinated ash) and pishti(powdered form without agni).These forms may have different rate of immersion. This needs to be studied. Aim: Pharmaceutical Standardization study of Praval Pishti & Praval Bhasma and comparative evaluation of their relative oral bioavailability. Materials and methods: The two formulations will be prepared from Praval (coral). By triturating with Gulab jala Praval Pishti will be prepared and by traditional Puta method Praval Bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, Physicochemical parameters and Particle size distribution analysis, SEM –EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), and GCMS (Gas Study Protocol Satpute et al.; JPRI, 33(31B): 54-60, 2021; Article no.JPRI.68585 55 Chromatography Mass Spectroscope) will be evaluated. To assess the relative oral bioavailability of Praval Pishti & Praval Bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement. Observation and results: The study will be assessed for its relative oral bioavailability in healthy Volunteers by using unpaired “t” Test, One-way ANOVA. Conclusion: The pharmaceutical study of Praval Bhasma and Praval Pishti will provide the standard parameters and comparative evaluation with standard will generate evidence for better bioavailability.
{"title":"Comparative Pharmaceutical Standardization and Oral Bioavailability Study on Praval Pishti and Praval Bhasma","authors":"Meghana Satpute, B. Rathi, A. Wanjari, Mujahid B. Khan","doi":"10.9734/JPRI/2021/V33I31B31690","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31690","url":null,"abstract":"Background: Praval (coral) is a very usually occurring calcium form. It is rich source of calcium & minerals. As per text it can be converted into two formulas which are bhasma (calcinated ash) and pishti(powdered form without agni).These forms may have different rate of immersion. This needs to be studied. Aim: Pharmaceutical Standardization study of Praval Pishti & Praval Bhasma and comparative evaluation of their relative oral bioavailability. Materials and methods: The two formulations will be prepared from Praval (coral). By triturating with Gulab jala Praval Pishti will be prepared and by traditional Puta method Praval Bhasma will be prepared. The prepared formulations will be assessed for Bhasma Pariksha mentioned in Ayurveda. Organoleptic characters, Physicochemical parameters and Particle size distribution analysis, SEM –EDX (Scanning Electron Microscopy, Energy Dispersive X-Ray Analysis), FTIR (Fourier-transform infrared spectroscopy), XRD (X-Ray Diffraction), and GCMS (Gas Study Protocol Satpute et al.; JPRI, 33(31B): 54-60, 2021; Article no.JPRI.68585 55 Chromatography Mass Spectroscope) will be evaluated. To assess the relative oral bioavailability of Praval Pishti & Praval Bhasma study will be conducted in healthy volunteers and will be compared with the standard calcium supplement. Observation and results: The study will be assessed for its relative oral bioavailability in healthy Volunteers by using unpaired “t” Test, One-way ANOVA. Conclusion: The pharmaceutical study of Praval Bhasma and Praval Pishti will provide the standard parameters and comparative evaluation with standard will generate evidence for better bioavailability.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"54-60"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44179278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-12DOI: 10.9734/JPRI/2021/V33I31B31693
Faraz Farooq Memon, M. Kashif, Z. Arain, S. Raza, Mehboob Ali, M. T. Raza, F. Memon
Objective: Cardiovascular diseases are 1.7 times more prevalent in patients with diabetes mellitus. The aim behind this study was to examine the correlation of glycosylated hemoglobin and complexity of coronary artery disease among middle aged population with diabetes mellitus Patients and Methods: This was a clinical prospective hospital-based comparative study carried out in the department of the cardiology department of Isra University Hospital Hyderabad for 10 months. 153 participants with diabetes mellitus having age ≥45 years both male and female and undergoing their first coronary angiography were included. Data were entered and analyzed by using Statistical Package for the Social Sciences version 21.0. Results: A total of 153 patients were finally analysed. Patients were divided into two groups; group I (HbA1c <6.5%, normal) and group II (HbA1c >6.5%, impaired). The mean age was slightly higher in group II 54.60 as compared to group I 53.65 years, respectively. The Syntax score was Original Research Article Memon et al.; JPRI, 33(31B): 79-85, 2021; Article no.JPRI.69867 80 correlated with HbA1c levels in patients older than 45 years of age (r = 0.001; p >0.05). Moreover, the higher HbA1c levels were observed in every three categories of Syntax score but they were insignificantly associated with each other in patients with diabetes mellitus and having age more than 45 years. Conclusion: The HbA1c is insignificantly correlated with the complexity of coronary artery disease in diabetic patients having age more than 45 years. While only two factors, hypertension and increased triglycerides are significantly different among the HbA1c groups.
{"title":"Correlation of Glycosylated Hemoglobin and Complexity of Coronary Artery Disease among Aged ≥45 Years Population with Diabetes Mellitus","authors":"Faraz Farooq Memon, M. Kashif, Z. Arain, S. Raza, Mehboob Ali, M. T. Raza, F. Memon","doi":"10.9734/JPRI/2021/V33I31B31693","DOIUrl":"https://doi.org/10.9734/JPRI/2021/V33I31B31693","url":null,"abstract":"Objective: Cardiovascular diseases are 1.7 times more prevalent in patients with diabetes mellitus. The aim behind this study was to examine the correlation of glycosylated hemoglobin and complexity of coronary artery disease among middle aged population with diabetes mellitus Patients and Methods: This was a clinical prospective hospital-based comparative study carried out in the department of the cardiology department of Isra University Hospital Hyderabad for 10 months. 153 participants with diabetes mellitus having age ≥45 years both male and female and undergoing their first coronary angiography were included. Data were entered and analyzed by using Statistical Package for the Social Sciences version 21.0. Results: A total of 153 patients were finally analysed. Patients were divided into two groups; group I (HbA1c <6.5%, normal) and group II (HbA1c >6.5%, impaired). The mean age was slightly higher in group II 54.60 as compared to group I 53.65 years, respectively. The Syntax score was Original Research Article Memon et al.; JPRI, 33(31B): 79-85, 2021; Article no.JPRI.69867 80 correlated with HbA1c levels in patients older than 45 years of age (r = 0.001; p >0.05). Moreover, the higher HbA1c levels were observed in every three categories of Syntax score but they were insignificantly associated with each other in patients with diabetes mellitus and having age more than 45 years. Conclusion: The HbA1c is insignificantly correlated with the complexity of coronary artery disease in diabetic patients having age more than 45 years. While only two factors, hypertension and increased triglycerides are significantly different among the HbA1c groups.","PeriodicalId":16706,"journal":{"name":"Journal of Pharmaceutical Research","volume":"1 1","pages":"79-85"},"PeriodicalIF":0.0,"publicationDate":"2021-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41990634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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