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Preloading peri-implant crestal bone loss: A retrospective study of incidence and related factors 种植体周围骨质流失:发病率及相关因素的回顾性研究。
IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-26 DOI: 10.1002/JPER.24-0028
Nathalia Vilela, Bruno C. V. Gurgel, Carlos De Bruzos, Wagner R. Duarte, Hélio D. P. da Silva, Claudio M. Pannuti, Poliana Mendes Duarte

Background

The aim of this study was to evaluate the incidence of preloading crestal bone loss (PLCBL) and to identify the patient-related and implant-related factors associated with PLCBL.

Methods

This retrospective cohort examined the dental records of patients who received at least one dental implant. PLCBL was defined as a reduction ⩾0.5 mm and severe PLCBL (primary variable) as a reduction ⩾1.5 mm in mesial and/or distal bone level, measured from the day of implant placement to uncovering or abutment installation/crown delivery. The incidence of PLCBL and patient and implant variables were recorded. Bivariate analysis and binary logistic regression identified factors associated with PLCBL ⩾0.5 mm and ⩾1.5 mm.

Results

A total of 746 dental implants placed in 361 patients from January 2011 to July 2021 was included in the analyses. Of the implants assessed, 24.4% (n = 182) exhibited PLCBL ⩾ 0.5 mm and 10.5% (n = 78) presented severe PLCBL (i.e., ⩾1.5 mm). Males (odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.11–3.07), patients with diabetes (OR = 3.33, 95% CI = 1.73–6.42), and those allergic to penicillin (OR = 3.13, 95% CI = 1.57–6.22) were more likely to experience severe PLCBL (p < 0.05). Implants placed in the anterior area (OR = 2.08, 95% CI = 1.16–3.73), with bone-level platform-abutment connection (OR = 4.73, 95% CI = 1.94–11.49) and inserted supracrestally (OR = 3.77, 95% CI = 1.84–7.72), presented a greater risk of developing severe PLCBL (p < 0.05). Implants placed in a previously grafted area presented a lower likelihood of developing severe PLCBL (OR = 0.489, 95% CI = 0.28–0.84).

Conclusion

The incidence of PLCBL ⩾ 0.5 mm and ⩾1.5 mm was 24.4% and 10.5%, respectively. Male sex, diabetes, allergy to penicillin, anterior location, bone-level platform-abutment connection, and supracrestal implant placement are potential risk factors for severe PLCBL. A previously grafted area is a potential protective factor.

背景:本研究旨在评估加载前骨嵴骨质流失(PLCBL)的发生率,并确定与PLCBL相关的患者和种植体因素:本研究旨在评估加载前骨嵴骨质流失(PLCBL)的发生率,并确定与 PLCBL 相关的患者相关因素和种植体相关因素:这项回顾性队列研究调查了至少接受过一次牙科植入手术的患者的牙科记录。PLCBL的定义是:从种植体植入当天到揭开基台或安装基台/制作牙冠期间,中轴和/或远端骨水平下降⩾0.5 mm,严重PLCBL(主要变量)下降⩾1.5 mm。记录了 PLCBL 的发生率以及患者和种植体的变量。双变量分析和二元逻辑回归确定了与PLCBL⩾0.5 mm和⩾1.5 mm相关的因素:2011年1月至2021年7月期间,共有361名患者植入了746颗牙科植入体。在接受评估的种植体中,24.4%(n = 182)的 PLCBL ⩾ 0.5 mm,10.5%(n = 78)的 PLCBL 严重(即⩾1.5 mm)。男性(比值比 [OR] = 1.85,95% 置信区间 [CI] = 1.11-3.07)、糖尿病患者(比值比 [OR] = 3.33,95% 置信区间 [CI] = 1.73-6.42)和青霉素过敏者(比值比 [OR] = 3.13,95% 置信区间 [CI] = 1.57-6.22)更有可能出现严重的 PLCBL(P 结论:PLCBL 的发病率为 0.5%-1.5%:PLCBL⩾0.5毫米和⩾1.5毫米的发病率分别为24.4%和10.5%。男性、糖尿病、对青霉素过敏、前牙位置、骨水平平台与基台连接以及上嵴种植体植入是导致严重PLCBL的潜在风险因素。以前移植过的区域则是潜在的保护因素。
{"title":"Preloading peri-implant crestal bone loss: A retrospective study of incidence and related factors","authors":"Nathalia Vilela,&nbsp;Bruno C. V. Gurgel,&nbsp;Carlos De Bruzos,&nbsp;Wagner R. Duarte,&nbsp;Hélio D. P. da Silva,&nbsp;Claudio M. Pannuti,&nbsp;Poliana Mendes Duarte","doi":"10.1002/JPER.24-0028","DOIUrl":"10.1002/JPER.24-0028","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the incidence of preloading crestal bone loss (PLCBL) and to identify the patient-related and implant-related factors associated with PLCBL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective cohort examined the dental records of patients who received at least one dental implant. PLCBL was defined as a reduction ⩾0.5 mm and severe PLCBL (primary variable) as a reduction ⩾1.5 mm in mesial and/or distal bone level, measured from the day of implant placement to uncovering or abutment installation/crown delivery. The incidence of PLCBL and patient and implant variables were recorded. Bivariate analysis and binary logistic regression identified factors associated with PLCBL ⩾0.5 mm and ⩾1.5 mm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 746 dental implants placed in 361 patients from January 2011 to July 2021 was included in the analyses. Of the implants assessed, 24.4% (<i>n</i> = 182) exhibited PLCBL ⩾ 0.5 mm and 10.5% (<i>n</i> = 78) presented severe PLCBL (i.e., ⩾1.5 mm). Males (odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.11–3.07), patients with diabetes (OR = 3.33, 95% CI = 1.73–6.42), and those allergic to penicillin (OR = 3.13, 95% CI = 1.57–6.22) were more likely to experience severe PLCBL (<i>p</i> &lt; 0.05). Implants placed in the anterior area (OR = 2.08, 95% CI = 1.16–3.73), with bone-level platform-abutment connection (OR = 4.73, 95% CI = 1.94–11.49) and inserted supracrestally (OR = 3.77, 95% CI = 1.84–7.72), presented a greater risk of developing severe PLCBL (<i>p</i> &lt; 0.05). Implants placed in a previously grafted area presented a lower likelihood of developing severe PLCBL (OR = 0.489, 95% CI = 0.28–0.84).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The incidence of PLCBL ⩾ 0.5 mm and ⩾1.5 mm was 24.4% and 10.5%, respectively. Male sex, diabetes, allergy to penicillin, anterior location, bone-level platform-abutment connection, and supracrestal implant placement are potential risk factors for severe PLCBL. A previously grafted area is a potential protective factor.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.2,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/JPER.24-0028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Periodontal and microbiological evaluation in cleft lip/palate patients undergoing orthodontic treatment: A cross‐sectional study 对接受正畸治疗的唇腭裂患者进行牙周和微生物评估:横断面研究
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-24 DOI: 10.1002/jper.24-0085
Ayush Khatri, Manish Khatri, Mansi Bansal, Puneet Batra, Sana Bint Aziz
BackgroundThe present cross‐sectional study was undertaken to evaluate the periodontal and microbiological parameters in patients with surgically repaired unilateral cleft lip and palate (UCLP) undergoing orthodontic correction in comparison to patients without any cleft or orthodontic treatment.MethodsA total of 120 patients, out of initial 148 patients, between the age group 6 and 18 years were enrolled and divided into four groups with 30 patients each: non‐cleft patients without orthodontic treatment in Group 1, non‐cleft patients undergoing fixed orthodontic treatment in Group 2, patients with UCLP without any orthodontic treatment in Group 3, and patients with UCLP undergoing fixed orthodontic treatment in Group 4. Periodontal parameters including plaque index (PI), gingival index (GI), gingival bleeding index (GBI), community periodontal index of treatment needs (CPITN) index, pocket probing depth (PD), and tooth mobility were measured in all the groups. The subgingival plaque samples of all the patients were subjected to microbial evaluation using matrix‐assisted laser desorption ionization‐time of flight mass spectrometry (MALDI‐TOF‐MS) for clinical diagnosis.ResultsThe periodontal parameters were significantly raised in Group 4, followed by Group 3 and Group 2 in comparison to Group 1 (p < 0.01), thereby suggesting poor periodontal health in patients with UCLP undergoing orthodontic treatment. Statistically significant differences (p < 0.01) in counts of micro‐organisms among the groups were observed for P. gingivalis, P. intermedia, Veillonella, and Capnocytophaga, with the highest proportions in Group 4, indicating a deteriorating oral health in these patients.ConclusionPoor periodontal and microbial health in patients with UCLP undergoing orthodontic treatment indicates a need for reinforcement of oral hygiene practices among these patients.
背景本横断面研究旨在评估接受正畸矫正的手术修复单侧唇腭裂(UCLP)患者的牙周和微生物参数,并与未接受任何唇裂或正畸治疗的患者进行比较。方法在最初的 148 名患者中,共招募了 120 名年龄在 6 至 18 岁之间的患者,并将其分为四组,每组 30 人:第一组为未接受正畸治疗的非唇裂患者,第二组为接受固定正畸治疗的非唇裂患者,第三组为未接受任何正畸治疗的单侧唇腭裂患者,第四组为接受固定正畸治疗的单侧唇腭裂患者。各组均测量了牙周参数,包括牙菌斑指数(PI)、牙龈指数(GI)、牙龈出血指数(GBI)、社区牙周治疗需求指数(CPITN)、牙周袋探诊深度(PD)和牙齿活动度。所有患者的龈下牙菌斑样本均采用基质辅助激光解吸电离飞行时间质谱法(MALDI-TOF-MS)进行微生物评估,以进行临床诊断。结果与第 1 组相比,第 4 组的牙周参数显著升高,第 3 组和第 2 组次之(p < 0.01),这表明接受正畸治疗的 UCLP 患者的牙周健康状况较差。在各组中,牙龈脓疱疮菌、中间脓疱疮菌、Veillonella 和 Capnocytophaga 的微生物计数差异有统计学意义(p < 0.01),其中第 4 组的比例最高,表明这些患者的口腔健康状况正在恶化。
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引用次数: 0
Correlation between short‐chain fatty acids and peri‐implant disease: A cross‐sectional study 短链脂肪酸与种植体周围疾病的相关性:横断面研究
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-21 DOI: 10.1002/jper.23-0682
Yue Liu, Hu Yang, Pingping Wang, Yilin Shi, Ruiwen Shi, Shengben Zhang, Yajun Zhao, Jing Lan, Shaohua Ge
BackgroundTo explore the correlation between short‐chain fatty acids (SCFAs) in the peri‐implant sulcular fluid (PISF) and peri‐implant diseases.MethodsPISF samples were obtained from implants that have been placed for at least 5 years, and peri‐implant clinical parameters were examined. Gas chromatography‐mass spectrometry and high‐performance liquid chromatography were used to detect SCFAs in PISF. The correlation between SCFAs and clinical parameters was analyzed by Spearman's correlation. SCFAs related to peri‐implant disease were identified by logistic regression and ranked by random forest analysis.ResultsEighty‐six implants were divided into a peri‐implant health group (PIH‐group, 35 implants), peri‐implant mucositis group (PIM‐group, 25 implants), and peri‐implantitis group (PI‐group, 26 implants) according to clinical and radiographic examination results. The PIM‐group had significantly lower formic acid detection rate than the other two groups (p < 0.001). The PIM‐group had significantly higher levels of acetic, propionic, and isovaleric acids than the PIH‐group (p < 0.05). The PI‐group had significantly higher levels of propionic, butyric, isobutyric, valeric, and isovaleric acids than the PIH‐group (p < 0.05). The PI‐group had significantly higher levels of butyric, isobutyric, and isovaleric acids than the PIM‐group (p < 0.05). SCFAs (apart from hexanoic and succinic acids) were significantly and positively correlated with clinical parameters (p < 0.05). SCFAs related to peri‐implant disease were ranked as follows: butyric, isovaleric, isobutyric, propionic, acetic, formic, and lactic acids.ConclusionsElevated specific SCFAs are correlated with peri‐implant disease. Recognition of this correlation may help in early identification of peri‐implant disease and guide further clinical interventions.
背景探讨种植体周围龈沟液(PISF)中的短链脂肪酸(SCFAs)与种植体周围疾病之间的相关性。方法从植入至少5年的种植体中获取PISF样本,并检查种植体周围的临床参数。采用气相色谱-质谱法和高效液相色谱法检测 PISF 中的 SCFAs。SCFAs 与临床参数之间的相关性通过斯皮尔曼相关性进行分析。结果 根据临床和影像学检查结果,将86颗种植体分为种植体周围健康组(PIH组,35颗种植体)、种植体周围粘膜炎组(PIM组,25颗种植体)和种植体周围炎组(PI组,26颗种植体)。PIM 组的甲酸检出率明显低于其他两组(P < 0.001)。PIM 组的乙酸、丙酸和异戊酸水平明显高于 PIH 组(p < 0.05)。PI 组的丙酸、丁酸、异丁酸、戊酸和异戊酸含量明显高于 PIH 组(p < 0.05)。PI 组的丁酸、异丁酸和异戊酸含量明显高于 PIM 组(p < 0.05)。SCFAs(己酸和琥珀酸除外)与临床参数呈显著正相关(p < 0.05)。与种植体周围疾病相关的 SCFAs 排列如下:丁酸、异戊酸、异丁酸、丙酸、乙酸、甲酸和乳酸。结论特定 SCFAs 的升高与种植体周围疾病有关,认识到这种相关性有助于早期识别种植体周围疾病并指导进一步的临床干预。
{"title":"Correlation between short‐chain fatty acids and peri‐implant disease: A cross‐sectional study","authors":"Yue Liu, Hu Yang, Pingping Wang, Yilin Shi, Ruiwen Shi, Shengben Zhang, Yajun Zhao, Jing Lan, Shaohua Ge","doi":"10.1002/jper.23-0682","DOIUrl":"https://doi.org/10.1002/jper.23-0682","url":null,"abstract":"BackgroundTo explore the correlation between short‐chain fatty acids (SCFAs) in the peri‐implant sulcular fluid (PISF) and peri‐implant diseases.MethodsPISF samples were obtained from implants that have been placed for at least 5 years, and peri‐implant clinical parameters were examined. Gas chromatography‐mass spectrometry and high‐performance liquid chromatography were used to detect SCFAs in PISF. The correlation between SCFAs and clinical parameters was analyzed by Spearman's correlation. SCFAs related to peri‐implant disease were identified by logistic regression and ranked by random forest analysis.ResultsEighty‐six implants were divided into a peri‐implant health group (PIH‐group, 35 implants), peri‐implant mucositis group (PIM‐group, 25 implants), and peri‐implantitis group (PI‐group, 26 implants) according to clinical and radiographic examination results. The PIM‐group had significantly lower formic acid detection rate than the other two groups (<jats:italic>p</jats:italic> &lt; 0.001). The PIM‐group had significantly higher levels of acetic, propionic, and isovaleric acids than the PIH‐group (<jats:italic>p</jats:italic> &lt; 0.05). The PI‐group had significantly higher levels of propionic, butyric, isobutyric, valeric, and isovaleric acids than the PIH‐group (<jats:italic>p</jats:italic> &lt; 0.05). The PI‐group had significantly higher levels of butyric, isobutyric, and isovaleric acids than the PIM‐group (<jats:italic>p</jats:italic> &lt; 0.05). SCFAs (apart from hexanoic and succinic acids) were significantly and positively correlated with clinical parameters (<jats:italic>p</jats:italic> &lt; 0.05). SCFAs related to peri‐implant disease were ranked as follows: butyric, isovaleric, isobutyric, propionic, acetic, formic, and lactic acids.ConclusionsElevated specific SCFAs are correlated with peri‐implant disease. Recognition of this correlation may help in early identification of peri‐implant disease and guide further clinical interventions.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141448327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature‐induced periodontitis in mice 黄酮类格桑皮素可保护牙槽骨并限制结扎诱发的小鼠牙周炎的炎症反应
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-21 DOI: 10.1002/jper.23-0541
Jiwon Seok, Myoung Ok Kim, Sung‐Hyun Kim, Ka‐Young Ryu, Jae‐Young Kim, Heon‐Jin Lee, Yong‐Gun Kim, Youngkyun Lee
BackgroundBacterial‐induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.MethodsIn the present study, we demonstrated an inhibitory effect of gossypetin, a hexahydroxy flavone, on osteoclast differentiation and bone resorption using in vitro culture of osteoclasts from mouse bone marrow macrophage (BMM) precursors and in vivo model of ligature‐induced periodontitis in mice.ResultsGossypetin significantly reduced the differentiation of osteoclasts from mouse BMM precursors in the presence of the receptor activator of nuclear factor κB ligand (RANKL). In vitro, gossypetin inhibited critical signaling events downstream of RANKL including the auto‐amplification of nuclear factor of activated T‐cells, cytoplasmic 1, Ca2+ oscillations, and the generation of reactive oxygen species. In a mouse ligature‐induced periodontitis model, the administration of gossypetin significantly reduced osteoclastogenesis and alveolar bone resorption. Furthermore, gossypetin prevented the ligature‐induced increase in macrophages and T cells and reduced the production of tumor necrosis factor‐α and interleukin‐6.ConclusionTaken together, these results show anti‐osteoclastogenic and anti‐inflammatory effects of gossypetin, suggesting the potential use of this natural compound in periodontitis.
背景在牙周炎中,细菌引起的炎症会破坏牙齿周围的软硬组织。在严重的情况下,破骨细胞数量和活性的增加会诱发牙槽骨的吸收,最终导致牙齿脱落。方法在本研究中,我们利用小鼠骨髓巨噬细胞(BMM)前体的破骨细胞体外培养和体内结扎诱导的小鼠牙周炎模型,证实了格桑吡丁(一种六羟基黄酮)对破骨细胞分化和骨吸收的抑制作用。结果格桑吡丁能在核因子κB配体受体激活剂(RANKL)存在的情况下明显减少小鼠骨髓巨噬细胞前体破骨细胞的分化。在体外,格塞品抑制了 RANKL 下游的关键信号事件,包括活化 T 细胞核因子的自动扩增、细胞质 1、Ca2+ 振荡和活性氧的产生。在小鼠结扎诱导的牙周炎模型中,格桑吡丁能显著减少破骨细胞的生成和牙槽骨的吸收。此外,格桑吡丁还能防止结扎诱导的巨噬细胞和 T 细胞的增加,并减少肿瘤坏死因子-α 和白细胞介素-6 的产生。结论综上所述,这些结果表明格桑吡丁具有抗破骨细胞生成和抗炎作用,表明这种天然化合物有可能用于治疗牙周炎。
{"title":"Flavonoid gossypetin protects alveolar bone and limits inflammation in ligature‐induced periodontitis in mice","authors":"Jiwon Seok, Myoung Ok Kim, Sung‐Hyun Kim, Ka‐Young Ryu, Jae‐Young Kim, Heon‐Jin Lee, Yong‐Gun Kim, Youngkyun Lee","doi":"10.1002/jper.23-0541","DOIUrl":"https://doi.org/10.1002/jper.23-0541","url":null,"abstract":"BackgroundBacterial‐induced inflammation instigates the destruction of hard and soft tissues surrounding teeth in periodontitis. In severe cases, the increased number and activity of osteoclasts induces the resorption of alveolar bones, ultimately leading to tooth loss. Because of their diverse chemical structures and bioactivities, natural compounds are often suggested to treat a wide variety of diseases, including inflammatory disorders.MethodsIn the present study, we demonstrated an inhibitory effect of gossypetin, a hexahydroxy flavone, on osteoclast differentiation and bone resorption using in vitro culture of osteoclasts from mouse bone marrow macrophage (BMM) precursors and in vivo model of ligature‐induced periodontitis in mice.ResultsGossypetin significantly reduced the differentiation of osteoclasts from mouse BMM precursors in the presence of the receptor activator of nuclear factor κB ligand (RANKL). In vitro, gossypetin inhibited critical signaling events downstream of RANKL including the auto‐amplification of nuclear factor of activated T‐cells, cytoplasmic 1, Ca<jats:sup>2+</jats:sup> oscillations, and the generation of reactive oxygen species. In a mouse ligature‐induced periodontitis model, the administration of gossypetin significantly reduced osteoclastogenesis and alveolar bone resorption. Furthermore, gossypetin prevented the ligature‐induced increase in macrophages and T cells and reduced the production of tumor necrosis factor‐α and interleukin‐6.ConclusionTaken together, these results show anti‐osteoclastogenic and anti‐inflammatory effects of gossypetin, suggesting the potential use of this natural compound in periodontitis.","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":null,"pages":null},"PeriodicalIF":4.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141448152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of antireaction medications on the association between periodontitis and leprosy reactions: An important methodological issue in periodontal medicine 抗反应药物对牙周炎与麻风反应之间关联的影响:牙周病学的一个重要方法论问题
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-21 DOI: 10.1002/jper.23-0725
Isabela de Souza Sacramento, Isaac Suzart Gomes‐Filho, Simone Seixas da Cruz, Soraya Castro Trindade, Ana Claudia Morais Godoy Figueiredo, Paulo Roberto Lima Machado, Maria Isabel Pereira Vianna, Michelle Miranda Lopes Falcão, Alexandre Marcelo Hintz, Juliana Andrade de Lacerda, Bruno Costa Matos, Gregory John Seymour, Frank Andrew Scannapieco, Peter Michael Loomer, Johelle de Santana Passos‐Soares
Background: The treatment of leprosy reactions (LRs) involves thalidomide, corticosteroids, and other immunomodulatory medications. This study evaluated the effect of these treatments on the association between periodontitis and LRs, as well as factors associated with LRs.Methods: This case–control study was conducted on 283 individuals followed at a leprosy outpatient clinic in Brazil. The case group was comprised of 158 individuals presenting type 1 or type 2 LRs, and the control group of 125 leprosy individuals without reactions. A complete oral examination was performed to diagnose periodontitis, the independent variable. Antireaction medication used was collected from medical records, and participants were classified according to the use of prednisone and/or thalidomide, time of use, or non‐use of medication. Socioeconomic–demographic, clinical, and lifestyle covariables were collected by interview. Unconditional logistic regression analysis by subgroups evaluated the effect of antireaction medication on the association between periodontitis and LRs, estimating the odds ratio with a 95% confidence interval (OR; 95% CI).Results: A relationship between periodontitis and LRs was observed only in the subgroup using the association prednisone and thalidomide: ORadjusted = 0.32; 95% CI = 0.11–0.95. Conversely, more severe periodontal clinical parameters were observed in cases versus controls. Several socioeconomic, health conditions, and lifestyle factors were associated with the presence of LRs.Conclusions: Although periodontal disease indicators were worse among the cases, the findings showed a negative relationship between periodontitis and LRs in individuals receiving associated prednisone and thalidomide. These medications appear to influence the inflammatory cascade between diseases, modifying and masking the manifestations of periodontitis.
背景:麻风反应(LRs)的治疗包括沙利度胺、皮质类固醇和其他免疫调节药物。本研究评估了这些治疗方法对牙周炎与麻风反应之间关系的影响,以及与麻风反应相关的因素:这项病例对照研究的对象是巴西麻风病门诊的 283 名随访者。病例组包括158名出现1型或2型LRs的麻风病人,对照组包括125名无反应的麻风病人。为诊断牙周炎(自变量)进行了全面的口腔检查。从医疗记录中收集所使用的抗反应药物,并根据泼尼松和/或沙利度胺的使用情况、使用时间或未使用药物对参与者进行分类。社会经济-人口学、临床和生活方式协变量通过访谈收集。按分组进行的无条件逻辑回归分析评估了抗反应药物对牙周炎与LRs之间关系的影响,估计了带有95%置信区间(OR;95% CI)的几率比:结果:仅在使用泼尼松和沙利度胺的亚组中观察到牙周炎与 LRs 之间的关系:调整后 OR = 0.32;95% CI = 0.11-0.95。相反,在病例与对照组中观察到更严重的牙周临床参数。一些社会经济、健康状况和生活方式因素与LRs的存在有关:结论:虽然病例的牙周病指标较差,但研究结果表明,在接受泼尼松和沙利度胺治疗的患者中,牙周炎和LRs之间存在负相关。这些药物似乎会影响疾病之间的炎症级联,改变和掩盖牙周炎的表现。
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引用次数: 0
Overexpression of the receptor for resolvin E1 (ERV1) prevents early alveolar bone loss in leptin receptor deficiency‐induced diabetes 过表达溶血素 E1(ERV1)受体可预防瘦素受体缺乏症诱发的糖尿病患者早期牙槽骨流失
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-21 DOI: 10.1002/jper.24-0060
Lina J. Suárez, Hatice Hasturk, Vanessa Tubero Euzebio Alves, David Díaz‐Baez, Thomas Van Dyke, Alpdogan Kantarci
BackgroundThis study was designed to test the hypothesis that the leptin receptor (LepR) regulates changes in periodontal tissues and that the overexpression of the receptor for resolvin E1 (ERV1) prevents age‐ and diabetes‐associated alveolar bone loss.MethodsLepR‐deficient transgenic (TG) mice were cross‐bred with those overexpressing ERV1 (TG) to generate double‐TG mice. In total, 95 mice were divided into four experimental groups: wild type (WT), TG, LepR deficient (db/db), and double transgenic (db/db TG). The groups were followed from 4 weeks up to 16 weeks of age. The natural progression of periodontal disease without any additional method of periodontitis induction was assessed by macroscopic and histomorphometric analyses. Osteoclastic activity was measured by tartrate‐resistant acid phosphatase (TRAP) staining.ResultsAt 4 weeks, ERV1 overexpression prevented weight gain. From Week 8 onward, there was a significant increase in the weight of db/db mice with or without ERV1 overexpression compared to the WT mice, accompanied by an increase in glucose levels. By 8 weeks of age, the percentage of bone loss in the LepR deficiency groups was significantly greater compared to WT mice. ERV1 overexpression in the db/db TG mice prevented early alveolar bone loss; however, it did not impact the development of diabetic bone loss in aging mice after the onset of weight gain and diabetes.ConclusionsThe findings suggest that the overexpression of ERV1 prevents LepR‐associated alveolar bone loss during the early phases of periodontal disease by delaying weight gain, diabetes onset, and associated inflammation; however, LepR deficiency increases susceptibility to naturally occurring inflammatory alveolar bone loss as the animal ages, associated with excess weight gain, onset of diabetes, and excess inflammation.
背景本研究旨在验证瘦素受体(LepR)调节牙周组织变化以及过表达溶血素E1(ERV1)受体可预防年龄和糖尿病相关牙槽骨丧失的假说。方法将LepR缺陷的转基因(TG)小鼠与过表达ERV1(TG)的小鼠杂交,产生双TG小鼠。总共 95 只小鼠被分为四个实验组:野生型(WT)、TG、LepR 缺陷(db/db)和双转基因(db/db TG)。实验组从 4 周龄开始随访至 16 周龄。通过宏观和组织形态学分析评估了牙周病的自然进展,而无需任何额外的牙周炎诱导方法。结果4周时,ERV1的过表达阻止了体重的增加。从第 8 周起,与 WT 小鼠相比,无论是否过表达 ERV1,db/db 小鼠的体重都有显著增加,同时血糖水平也有所上升。到8周龄时,与WT小鼠相比,LepR缺乏组的骨质流失比例明显增加。ERV1 在 db/db TG 小鼠中的过表达可防止早期牙槽骨流失;但在体重增加和糖尿病发生后,ERV1 的过表达并不影响老龄小鼠糖尿病骨流失的发展。结论研究结果表明,在牙周病的早期阶段,ERV1的过表达可通过延迟体重增加、糖尿病发病和相关炎症来防止与LepR相关的牙槽骨流失;然而,随着动物年龄的增长,LepR的缺乏会增加自然发生的炎症性牙槽骨流失的易感性,这与体重增加过多、糖尿病发病和炎症过多有关。
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引用次数: 0
Evaluation of circulating IgG antibodies against Porphyromonas gingivalis or its gingipains as serological markers of periodontitis and carriage of the bacterium. 将针对牙龈卟啉单胞菌或其龈肽的循环 IgG 抗体作为牙周炎和细菌携带的血清学标志物进行评估。
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-17 DOI: 10.1002/JPER.23-0766
Laura Massarenti, Claus Henrik Nielsen, Anne Katrine Danielsen, Peter Østrup Jensen, Christian Enevold, Christian Damgaard

Background: Increasing evidence indicates that periodontitis contributes to systemic low-grade inflammation. Porphyromonas gingivalis is strongly associated with periodontitis, and antibodies against the bacterium may be used as a serological proxy to account for periodontal status, when studying diseases associated with periodontitis. The aim of the present study is to identify an easily accessible and reliable serological biomarker for determination of periodontal status and oral carriage of the bacterium.

Methods: Saliva and serum samples were collected from periodontally healthy controls (n = 27), and patients with periodontitis stage II (n = 12) or stages III or IV (n = 44). Serum levels of immunoglobulin G (IgG) antibodies against intact and fragmented P. gingivalis, recombinant gingipains (RgpA and RgpB), and the bacteria Escherichia coli and Capnocytophaga ochracea as controls were quantified with a multiplex bead-based assay. P. gingivalis was identified in saliva using quantitative polymerase chain reaction (qPCR).

Results: Serum IgG antibodies against P. gingivalis whole bacteria were good indicators of periodontitis (area under the curve [AUC]: 0.75, 95% confidence interval [CI]: 0.64-0.85). The same was observed for levels of antibodies against P. gingivalis fragments (AUC: 0.78, 95% CI: 0.68-0.88). Likewise, levels of antibodies against P. gingivalis whole bacteria or P. gingivalis fragments were good indicators of oral carriage of P. gingivalis (AUC: 0.92, 95% CI: 0.86-0.98 and AUC: 0.96, 95% CI: 0.92-1, respectively). Conversely, antibodies against recombinant RgpA and RgpB were not good indicators of periodontitis or oral carriage of the bacterium. None of the antibody levels differed significantly between stage II and stage III or IV periodontitis.

Conclusion: Serum IgG antibody levels against heat-inactivated whole P. gingivalis proved to be the preferable biomarker for periodontitis and oral carriage of the bacterium.

背景:越来越多的证据表明,牙周炎会导致全身性低度炎症。牙龈卟啉单胞菌(Porphyromonas gingivalis)与牙周炎密切相关,在研究与牙周炎相关的疾病时,针对牙龈卟啉单胞菌的抗体可作为一种血清学替代物来说明牙周状况。本研究的目的是确定一种易于获得且可靠的血清学生物标志物,用于确定牙周状况和该细菌的口腔携带情况:方法:从牙周健康的对照组(27 人)和牙周炎 II 期(12 人)、III 期或 IV 期(44 人)患者中采集唾液和血清样本。采用基于多聚酶珠的检测方法对血清中针对完整和片段牙龈脓杆菌、重组牙龈肽(RgpA 和 RgpB)以及作为对照的大肠杆菌和嗜口荚膜梭菌的免疫球蛋白 G (IgG) 抗体水平进行量化。使用定量聚合酶链反应(qPCR)鉴定唾液中的牙龈脓疱疮杆菌:结果:血清中针对牙龈脓疱病菌的 IgG 抗体是牙周炎的良好指标(曲线下面积 [AUC]:0.75,95% 置信区间 [CI]:0.64-0.85)。针对牙龈片段的抗体水平也是如此(AUC:0.78,95% 置信区间:0.68-0.88)。同样,针对牙龈脓杆菌全菌或牙龈脓杆菌片段的抗体水平也是牙龈脓杆菌口腔携带的良好指标(AUC:0.92,95% CI:0.86-0.98;AUC:0.96,95% CI:0.92-1)。相反,针对重组 RgpA 和 RgpB 的抗体不是牙周炎或口腔带菌的良好指标。II期牙周炎与III期或IV期牙周炎的抗体水平均无明显差异:结论:针对热灭活全牙龈脓毒性杆菌的血清 IgG 抗体水平被证明是牙周炎和口腔带菌的理想生物标志物。
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引用次数: 0
Donor site wound healing following free gingival graft surgery using platelet rich fibrin: A randomized controlled trial 使用富血小板纤维蛋白进行游离龈移植手术后供体部位的伤口愈合:随机对照试验
IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-17 DOI: 10.1002/JPER.24-0072
Se'quon M. H. Scott, Julia A. Lacy, Archontia A. Palaiologou, Georgios A. Kotsakis, David E. Deas, Brian L. Mealey

Background

The primary purpose of this two-arm, parallel design, randomized controlled study is to compare healing of the palatal tissue donor site when platelet-rich fibrin (PRF) is used as a wound dressing compared to the use of a hemostatic agent. Secondary outcomes of patient pain perception and analgesic intake were also evaluated.

Methods

Seventy-four patients receiving free gingival grafts were randomized to receive either PRF (test) or hemostatic agent (control) as a palatal wound dressing by patients selecting a sealed envelope containing their group assignment (initially 37 envelopes for PRF group and 37 for hemostatic agent group). Patient pain assessment and analgesic consumption were documented using a 21-point numerical scale (NMRS-21) at 24, 48, and 72 hours post-surgery. At 1-, 2-, 3-, and 4-week follow-up appointments palatal early healing index (PEHI) scores including wound color, epithelialization, presence or absence of swelling, granulation tissue, and bleeding on gentle palpation were generated by direct intraoral examination by a blinded examiner unaware of the patients’ treatment group.

Results

NMRS-21 pain scores showed a significant reduction in pain over time in both groups, with no significant difference between groups at any time point. No significant between-group difference was found in the amount of analgesics taken by patients at 24, 48, and 72 hours. There was significant improvement in PEHI scores over the 4-week time period in both groups, but there was no significant difference in PEHI score at each time point (1, 2, 3, 4 weeks) between groups. 

Conclusions

Study findings suggest that there is no difference in early palatal wound healing, patient pain perception, or analgesic consumption between use of PRF or a hemostatic agent as donor-site wound dressings.

研究背景这项双臂、平行设计、随机对照研究的主要目的是比较使用富血小板纤维蛋白(PRF)作为伤口敷料与使用止血剂时腭组织供体部位的愈合情况。研究还评估了患者疼痛感和镇痛剂摄入量的次要结果:74名接受游离牙龈移植的患者被随机分配到PRF(试验组)或止血剂(对照组)作为腭部伤口敷料。在手术后 24、48 和 72 小时,使用 21 点数字量表(NMRS-21)记录患者的疼痛评估和止痛药消耗量。在 1、2、3 和 4 周的随访中,腭部早期愈合指数(PEHI)评分包括伤口颜色、上皮化、有无肿胀、肉芽组织和轻轻触诊时的出血情况,评分由一名不知道患者治疗组别的盲人检查员通过直接口腔内检查得出:结果:NMRS-21 疼痛评分显示,两组患者的疼痛均随时间推移而明显减轻,组间在任何时间点均无明显差异。在 24、48 和 72 小时内,患者服用镇痛药的剂量在组间无明显差异。在为期四周的时间里,两组患者的 PEHI 评分均有明显改善,但在每个时间点(1、2、3、4 周),两组患者的 PEHI 评分均无明显差异。 结论:研究结果表明,使用 PRF 或止血剂作为供体部位伤口敷料,在早期腭部伤口愈合、患者疼痛感觉或镇痛药消耗方面没有差异。
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引用次数: 0
Effect of alveolar ridge preservation at periodontally compromised molar extraction sockets: A retrospective cohort study. 牙周受损的臼齿拔牙窝的牙槽嵴保留效果:回顾性队列研究
IF 4.3 2区 医学 Q1 Dentistry Pub Date : 2024-06-17 DOI: 10.1002/JPER.24-0064
Anna Dai, Hao-Yu Li, Sen Kang, Renjie Lin, Jia-Ping Huang, Feifei Mao, Pei-Hui Ding

Background: To date, the clinical evidence regarding the effectiveness of alveolar ridge preservation (ARP) in restricting alveolar bone height and width change after extraction at periodontally compromised molar extraction sockets still remains controversial. This retrospective cohort study aims to evaluate the effect of ARP in molars extracted for periodontal reasons.

Methods: Retrospective data were collected from patient electronic records from January 2019 to December 2023. Patients with Stage III/IV periodontitis who underwent extraction of molars for periodontal reasons were screened for eligibility. The outcomes included the horizontal and vertical dimensions of alveolar bone. The need for additional augmentation procedure during implantation was also evaluated. A linear regression model was used to adjust for known confounders.

Results: A total of 80 sockets were included in this study, of which 27 sockets received ARP therapy after extraction while 53 sockets experienced natural healing (NH). ARP resulted in significantly less bone height change in the periodontally compromised molar sites compared to the NH group (p < 0.001). In sockets displaying a height disparity of >2 mm between the buccal and palatal/lingual walls, the ARP group exhibited advantageous outcomes in terms of ridge width change, surpassing the NH group (p = 0.004). Moreover, the percentage for additional augmentation was significantly reduced in the ARP compared to the NH group (p = 0.006). Age, sex, smoking, jaw, location, and buccal wall thickness did not show any significant effect on bone height change.

Conclusion: ARP had benefits on limiting ridge resorption subsequent to molar extraction for periodontal reasons.

背景:迄今为止,关于牙槽嵴保留(ARP)在牙周受损的磨牙拔牙窝拔牙后限制牙槽骨高度和宽度变化的有效性的临床证据仍然存在争议。这项回顾性队列研究旨在评估因牙周原因拔除的磨牙的牙槽嵴保留效果:从 2019 年 1 月至 2023 年 12 月的患者电子记录中收集回顾性数据。筛选出因牙周原因拔除磨牙的 III/IV 期牙周炎患者。研究结果包括牙槽骨的水平和垂直尺寸。此外,还评估了在种植过程中是否需要进行额外的增量手术。采用线性回归模型对已知的混杂因素进行调整:本研究共纳入了 80 个基台,其中 27 个基台在拔牙后接受了 ARP 治疗,53 个基台经历了自然愈合(NH)。与自然愈合组相比,ARP 使牙周受损的磨牙部位的骨高度变化明显较小(P = 2 mm),ARP 组在牙脊宽度变化方面表现出优势,超过了自然愈合组(P = 0.004)。此外,与 NH 组相比,ARP 组的额外增量比例明显降低(p = 0.006)。年龄、性别、吸烟、颌骨、位置和颊壁厚度对骨高度变化没有明显影响:结论:ARP对限制因牙周原因拔除臼齿后的牙脊吸收有好处。
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引用次数: 0
Impact of surface chemical treatment in surgical regenerative treatment of ligature-induced peri-implantitis: A canine study 表面化学处理对结扎引起的种植体周围炎手术再生治疗的影响:犬类研究
IF 4.2 2区 医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE Pub Date : 2024-06-16 DOI: 10.1002/JPER.23-0634
Shu-Jiao Qian, Yi-Wen Tsai, Theofilos Koutouzis, Hong-Chang Lai, Shi-Chong Qiao, Georgios A. Kotsakis

Background

Implant surface decontamination is a critical step in peri-implantitis treatment. The aim of this study was to assess the effect chemotherapeutic agents have on reosseointegration after treatment on ligature-inducted peri-implantitis.

Methods

Six male canines had 36 implants placed and ligatures were placed around them for 28 weeks to establish peri-implantitis. The peri-implant defects were randomly treated by 1 of 3 methods: 0.12% chlorhexidine (CHX test group), 1.5% sodium hypochlorite (NaOCl test group), or saline (Control group). Sites treated with NaOCl and CHX were grafted with autogenous bone, and all sites then either received a collagen membrane or not. Histology sections were obtained at 6 months postsurgery to assess percentage of reosseointegration.

Results

Thirty-five implants were analyzed (CHX: 13; NaOCl: 14; Control:8). NaOCl-treated sites demonstrated reosseointegration with direct bone-to-implant-contact on the previously contaminated surfaces (42% mean reosseointegration), which was significantly higher than Controls (p < 0.05). Correspondingly, clinical improvement was noted with a significant reduction in probing depth from 5.50 ± 1.24 mm at baseline to 4.46 ± 1.70 mm at 6-months postsurgery (p = 0.006). CHX-treated sites demonstrated a nonsignificant reosseointegration of 26% (p > 0.05); however, in the majority of cases, the new bone growth was at a distance from the implant surface without contact. Probing depths did not improve in the CHX group. The use of membrane did not influence reosseointegration or probing depths (all p > 0.05).

Conclusion

Titanium implants with peri-implantitis have the capacity to reosseointegrate following regenerative surgery. However, treatment response is contingent upon the chemotherapeutic agent selection. Additional chemical treatment with 1.5% NaOCl lead to the most favorable results in terms of changes in defect depth and percentage of reosseointegration as compared to CHX, which may hinder reosseointegration.

背景:种植体表面净化是治疗种植体周围炎的关键步骤。本研究的目的是评估化疗药物对结扎引起的种植体周围炎治疗后的再骨结合的影响:方法:六颗雄性犬牙植入了36颗种植体,并在种植体周围植入结扎带28周,以建立种植体周围炎。种植体周围缺损随机采用三种方法中的一种进行治疗:0.12% 洗必泰(CHX 试验组)、1.5% 次氯酸钠(NaOCl 试验组)或生理盐水(对照组)。用 NaOCl 和 CHX 处理过的部位会移植自体骨,然后所有部位都会接受或不接受胶原蛋白膜。术后 6 个月时进行组织学切片检查,以评估再骨合的百分比:对 35 个种植体进行了分析(CHX:13 个;NaOCl:14 个;对照组:8 个)。经 NaOCl 处理过的部位显示,在先前污染的表面上,骨与种植体直接接触,实现了再骨结合(平均再骨结合率为 42%),明显高于对照组(P 0.05);但在大多数情况下,新骨生长与种植体表面有一定距离,没有接触。CHX 组的探查深度没有改善。膜的使用对再骨结合或探诊深度没有影响(均 p > 0.05):结论:患有种植体周围炎的钛种植体有能力在再生手术后重新骨结合。然而,治疗反应取决于化疗药物的选择。与可能阻碍再结合的 CHX 相比,使用 1.5% NaOCl 进行额外的化学处理在缺损深度变化和再结合百分比方面取得了最理想的效果。
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引用次数: 0
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Journal of periodontology
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