Journal of periodontology最新文献_第6页

Risk factors for the failure of re-implanted dental implants: A 20-year retrospective study 再植牙失败的风险因素：一项为期 20 年的回顾性研究。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-31 DOI: 10.1002/JPER.24-0198

Cheol-Min Kim, Jong-Bin Lee, Heung-Sik Um, Jae-Kwan Lee

Background

Re-implantation of failed implants is common to maintain the original prosthetic plan; however, it may not always be ideal due to various factors. Few studies have thoroughly investigated the outcomes of re-implanted implants, while considering factors that can enhance their survival rates. Therefore, this study aimed to identify the risk factors that may contribute to the refailure of implants placed the second time by analyzing previously failed implants and evaluating their survival.

Methods

Of 10,666 dental implants placed in 4063 patients at the Department of Periodontics of the Gangneung–Wonju National University Dental Hospital between December 1999 and March 2021, 259 failed implants in 170 patients were evaluated through clinical and radiographic records for patient-, surgical-, implant-, and prosthesis-related factors; survival analysis was conducted for implants that met the inclusion criteria.

Results

Of the 259 failed implants, 80 second-time–placed implants met the inclusion criteria. Survival analysis showed that the 1-year survival rate of second-time–placed implants was 88.1%. Smoking (hazard ratio [HR] = 5.066, p = 0.081), implant surface (HR = 18.776, p < 0.01), and timing of reimplantation (HR = 0.086, p < 0.01) were identified as risk factors influencing the refailure of second-time–placed implants.

Conclusions

The survival rate of second-time–placed implants was lower than that of first-time–placed implants. The risk factors for second-time–placed implant failure were smoking, implant surface, and timing of reimplantation. To prevent further failure, previous failure factors should be analyzed and modifiable risk factors must be controlled before reimplantation.

背景：为了保持原有的修复计划，对失败的种植体进行再植入是很常见的做法；然而，由于各种因素的影响，再植入的效果并不总是很理想。很少有研究对再次植入种植体的结果进行深入调查，同时考虑可提高其存活率的因素。因此，本研究旨在通过分析以前失败的种植体并评估其存活率，找出可能导致第二次种植失败的风险因素：在 1999 年 12 月至 2021 年 3 月期间，国立江陵-原州大学牙科医院牙周科为 4063 名患者植入了 10666 个种植体，通过临床和影像记录对 170 名患者的 259 个失败种植体进行了患者、手术、种植体和修复体相关因素的评估，并对符合纳入标准的种植体进行了存活率分析：结果：在 259 个失败的种植体中，有 80 个二次植入的种植体符合纳入标准。生存分析表明，二次植入种植体的 1 年生存率为 88.1%。吸烟（危险比 [HR] = 5.066，P = 0.081）、种植体表面（HR = 18.776，P二次植入种植体的存活率低于首次植入种植体。二次植入失败的风险因素是吸烟、植入体表面和再次植入的时间。为防止再次失败，应分析之前的失败因素，并在再次植入前控制可改变的风险因素。

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引用次数: 0

Correction to "Salivary cytokine expression after nonsurgical periodontal therapy in smokers: 12-month follow-up". 对 "吸烟者接受非手术牙周治疗后唾液细胞因子的表达：12 个月随访"。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-22 DOI: 10.1002/jper.11256

引用次数: 0

Oxidative balance scores in Korean adults are associated with periodontitis 韩国成年人的氧化平衡评分与牙周炎有关。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-18 DOI: 10.1002/JPER.24-0164

Jeong-Hwa Seon, Na-Yeong Kim, Ji-Eun Kim, Choong-Ho Choi, Ki-Ho Chung

Background

The Oxidative Balance Score (OBS) is a comprehensive metric that assesses the state of a person's oxidative balance. This study aimed to investigate the relationship between the oxidative balance score and moderate and severe periodontitis in a representative sample of Korean adults.

Methods

Healthcare big data from the 7th Korea National Health and Nutrition Examination Survey (2016–2018) was used, and 16,489 adults aged ≥19 years were included. Multivariate logistic regression analysis was performed to investigate the effect of sex-specific oxidative balance scores on periodontitis.

Results

In comparison with participants with a lower oxidative balance score, those with a higher oxidative balance score had a lower incidence of moderate and severe periodontitis (p < 0.05). After adjusting for covariates, the oxidative balance score was negatively associated with moderate (odds ratio [OR] = 0.952; 95% confidence interval [CI]: 0.934–0.971) and severe (OR = 0.958; 95% CI: 0.931–0.986) periodontitis; however, the result was not significant for severe periodontitis in women's (OR = 0.975; 95% CI: 0.934–1.018). Our study showed a statistically significant association between OBS and moderate and severe periodontitis, the small effect size should be interpreted with caution.

Conclusions

The oxidative balance score was associated with moderate and severe periodontitis in Korean adults. Therefore, managing this score may help reduce the risk of periodontitis.

背景介绍氧化平衡评分（OBS）是评估一个人氧化平衡状况的综合指标。本研究旨在调查具有代表性的韩国成年人样本中，氧化平衡得分与中度和重度牙周炎之间的关系。方法：采用第7次韩国国民健康与营养调查（2016-2018年）的医疗保健大数据，纳入16489名年龄≥19岁的成年人。采用多变量逻辑回归分析研究了性别特异性氧化平衡评分对牙周炎的影响：结果：与氧化平衡得分较低的参与者相比，氧化平衡得分较高的参与者中度和重度牙周炎的发病率较低（p 结论：氧化平衡得分与牙周炎的发病率有关：氧化平衡得分与韩国成年人的中度和重度牙周炎有关。因此，管理好氧化平衡评分有助于降低牙周炎的风险。

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引用次数: 0

Disparate effects of sclerostin deletion on alveolar bone and cellular cementum in mice 小鼠硬骨素缺失对牙槽骨和细胞骨水泥的不同影响。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-16 DOI: 10.1002/JPER.24-0025

Aonjittra Phanrungsuwan, Michael B. Chavez, Leena A. Eltilib, Tamara N. Kolli, Fatma F. Mohamed, Michelle H. Tan, Cristiane R. Salmon, Francisco H. Nociti Jr., Brian L. Foster

<div> <section> <h3> Background</h3> <p>Cellular cementum (CC) includes cementocytes, cells suspected to regulate CC formation or resorption as osteocytes do in bone. Sclerostin (SOST) is a secreted negative regulator of Wnt/β-catenin signaling expressed by osteocytes and cementocytes. Osteocyte SOST expression reduces bone formation. We investigated the functional importance of SOST in CC compared with alveolar bone (AB) using a <i>Sost</i> knockout (<i>Sost<sup>−/−</sup></i>) mouse model to better understand the role of cementocytes in CC.</p> </section> <section> <h3> Methods</h3> <p>Mandibles and femurs of <i>Sost<sup>−/−</sup></i> and wild-type (WT) mice were analyzed at 42 and 120 days postnatal (dpn). Maxillary first molars were bilaterally extracted at 42 dpn and both AB healing (maxillary molar sockets) and CC apposition (mandibular first molars) were examined at 21 days post-procedure. Analyses included micro-computed tomography, histology, and immunohistochemistry.</p> </section> <section> <h3> Results</h3> <p>Femur cortical and trabecular bone and mandibular bone volumes were similarly increased in <i>Sost<sup>−/−</sup></i> versus WT mice at 42 and/or 120 dpn. In contrast to previous reports, CC was not increased by <i>Sost<sup>−/−</sup></i> at either age. We conducted challenge experiments on AB and CC to explore tissue-specific responses. Post-extraction AB healing was improved by <i>Sost</i> deletion. In contrast, experimentally-induced apposition in molars failed to stimulate increased CC formation in <i>Sost<sup>−/−</sup></i> versus WT mice. Wnt pathway markers AXIN2 and DKK1, which were increased in <i>Sost<sup>−/−</sup></i> versus WT AB osteocytes, were unchanged in cementocytes.</p> </section> <section> <h3> Conclusions</h3> <p>These data indicate CC is less responsive than AB to SOST deletion. Within the study limitations, these results do not support cementocytes as critical for directing increased CC formation.</p> </section> <section> <h3> Plain Language Summary</h3> <p>Sclerostin is a protein known to inhibit bone formation, and removing sclerostin leads to more bone formation. Cementum is the thin layer that covers the surface of the tooth's root. Previous studies suggest that inhibiting sclerostin can similarly increase the amount of cementum. We wanted to compare the response of cementum and bone when sclerostin is absent to understand similarities and differences between these two tissues. In this study, we removed the

背景：细胞骨水泥（CC）包括骨水泥细胞，这些细胞被怀疑与骨中的成骨细胞一样调节CC的形成或吸收。Sclerostin（SOST）是一种由骨细胞和骨水泥细胞表达的Wnt/β-catenin信号转导的分泌型负调控因子。骨细胞 SOST 的表达会减少骨形成。我们使用 Sost 基因敲除（Sost-/-）小鼠模型研究了与牙槽骨（AB）相比，SOST 在 CC 中的功能重要性，以更好地了解骨水泥细胞在 CC 中的作用：方法：在出生后42天和120天（dpn）对Sost-/-小鼠和野生型（WT）小鼠的下颌骨和股骨进行分析。42 dpn时拔除双侧上颌第一磨牙，术后21天检查AB愈合（上颌磨牙窝）和CC附着（下颌第一磨牙）情况。分析包括微型计算机断层扫描、组织学和免疫组化：结果：在42和/或120 dpn时，Sost-/-与WT小鼠相比，股骨皮质骨和骨小梁以及下颌骨体积同样增加。与之前的报告相反，Sost-/-小鼠在这两个年龄段的 CC 都没有增加。我们对 AB 和 CC 进行了挑战实验，以探索组织特异性反应。Sost 基因缺失可改善拔牙后 AB 的愈合。相反，实验诱导的臼齿贴合未能刺激 Sost-/- 与 WT 小鼠相比更多的 CC 形成。Wnt 通路标记 AXIN2 和 DKK1 在 Sost-/- 相对于 WT AB 骨细胞中增加，但在骨水泥细胞中没有变化：这些数据表明，CC对SOST缺失的反应性低于AB。在研究的局限性内，这些结果并不支持骨水泥细胞是引导 CC 形成增加的关键。白话摘要：硬骨素是一种已知会抑制骨形成的蛋白质，去除硬骨素会导致更多的骨形成。骨水泥是覆盖在牙根表面的薄层。以前的研究表明，抑制硬骨素同样可以增加骨水泥的数量。我们希望比较当硬骨素缺失时骨水泥和骨的反应，以了解这两种组织之间的异同。在这项研究中，我们移除了小鼠的 Sost 基因（产生硬骨素的基因）。我们发现，没有硬骨素的小鼠腿部和下颌的骨骼更多。此外，与正常小鼠相比，没有硬骨素的小鼠在拔牙后的愈合情况也更好。令人惊讶的是，与以往的研究不同，我们发现没有硬骨素的小鼠与正常小鼠相比，骨水泥的数量并无不同。此外，我们还通过拔除对侧牙齿来挑战牙本质，使第一下颌臼齿通过形成更多的牙本质而上移。即使进行了这种挑战，我们也发现缺乏硬骨素的小鼠与正常小鼠的骨水泥数量没有差异。因此，我们在此得出结论：与骨骼相比，骨水泥对硬骨素缺失的敏感性较低。

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引用次数: 0

In vitro comparison of zinc-based, chlorhexidine, and essential oil mouth rinses. 锌基、洗必泰和精油漱口水的体外比较。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-16 DOI: 10.1002/JPER.23-0619

Thomas E Lallier, Brian S Goldfarb, Pooja Maney

Background: Chlorhexidine (CHX)-based mouth rinses are frequently prescribed following periodontal surgeries. A more recently available brand of zinc-based mouth rinses advertises one of its mouth rinses as a substitute for chlorhexidine. The purpose of this study was to evaluate, in vitro, the effects of this brand of zinc-based mouth rinses on cell survival, cell motility, and gene expression of human gingival fibroblasts (HGFs).

Methods: HGFs were exposed to essential oil (EO), CHX, and three types of one brand of zinc-based mouth rinses designed to treat breath malodor (ZnA), dry mouth (ZnB), and gingivitis (ZnC). Each mouth rinse was tested over a range of concentrations for its effects on HGF survival and motility. Gene expression of cytokines, interleukins, and growth factors were evaluated via reverse transcriptase-polymerase chain reaction (RT-PCR), as a means to assess potential influences on inflammation and wound healing.

Results: Cell survival was significantly decreased for CHX and ZnC at 10% dilutions (p < 0.05). For all time points, cells exposed to ZnC displayed the greatest reduction in cell motility (p < 0.05). The various mouth rinses examined differentially altered the expression of growth factor transcripts. ZnC particularly enhanced the expression of BMP-2 and FGF-2.

Conclusion: ZnC was more cytotoxic and inhibited cell motility to a greater extent than any of the other mouth rinses. Therefore, using ZnC as an alternative to CHX could potentially have negative effects on wound healing after periodontal surgery. However, further investigation is required to confirm the clinical relevance of these in vitro findings.

Plain language summary: One type of zinc-based mouth rinse designed to replace chlorhexidine (often prescribed after oral surgeries) demonstrated the greatest oral cell death and reduction in cell movement when compared to other zinc-based mouth rinses. These zinc-based mouth rinses also reduced the amounts of proteins involved in regulating inflammation, potentially reducing the destruction of bone holding the teeth in place. They also changed the amounts of several molecules involved in tissue healing. It is unknown if this will speed or slow the healing of the soft tissues of the mouth.

背景：牙周手术后经常会使用洗必泰（CHX）漱口水。最近上市的一种锌基漱口水品牌宣传其漱口水可替代洗必泰。本研究的目的是在体外评估该品牌锌漱口水对细胞存活、细胞运动和人牙龈成纤维细胞（HGFs）基因表达的影响。方法：将 HGFs 暴露于精油（EO）、CHX 和一种品牌的三种锌漱口水中，这些漱口水分别用于治疗口臭（ZnA）、口干（ZnB）和牙龈炎（ZnC）。每种漱口水都在一定浓度范围内测试了其对成纤维细胞生长因子存活和运动的影响。通过反转录聚合酶链反应（RT-PCR）评估细胞因子、白细胞介素和生长因子的基因表达，以此评估对炎症和伤口愈合的潜在影响：结果：CHX 和 ZnC 的细胞存活率在 10%稀释度时明显降低（p 结论：CHX 和 ZnC 的细胞毒性更强：与其他漱口水相比，ZnC 的细胞毒性更强，对细胞运动的抑制作用更大。因此，使用 ZnC 作为 CHX 的替代品可能会对牙周手术后的伤口愈合产生负面影响。白话摘要：与其他锌基漱口水相比，一种旨在替代洗必泰（通常在口腔手术后处方）的锌基漱口水显示出最大的口腔细胞死亡和细胞运动减少。这些锌漱口水还减少了参与调节炎症的蛋白质数量，从而可能减少对固定牙齿的骨骼的破坏。它们还改变了参与组织愈合的几种分子的数量。目前还不清楚这是否会加速或减缓口腔软组织的愈合。

{"title":"In vitro comparison of zinc-based, chlorhexidine, and essential oil mouth rinses.","authors":"Thomas E Lallier, Brian S Goldfarb, Pooja Maney","doi":"10.1002/JPER.23-0619","DOIUrl":"https://doi.org/10.1002/JPER.23-0619","url":null,"abstract":"<p><strong>Background: </strong>Chlorhexidine (CHX)-based mouth rinses are frequently prescribed following periodontal surgeries. A more recently available brand of zinc-based mouth rinses advertises one of its mouth rinses as a substitute for chlorhexidine. The purpose of this study was to evaluate, in vitro, the effects of this brand of zinc-based mouth rinses on cell survival, cell motility, and gene expression of human gingival fibroblasts (HGFs).</p><p><strong>Methods: </strong>HGFs were exposed to essential oil (EO), CHX, and three types of one brand of zinc-based mouth rinses designed to treat breath malodor (ZnA), dry mouth (ZnB), and gingivitis (ZnC). Each mouth rinse was tested over a range of concentrations for its effects on HGF survival and motility. Gene expression of cytokines, interleukins, and growth factors were evaluated via reverse transcriptase-polymerase chain reaction (RT-PCR), as a means to assess potential influences on inflammation and wound healing.</p><p><strong>Results: </strong>Cell survival was significantly decreased for CHX and ZnC at 10% dilutions (p < 0.05). For all time points, cells exposed to ZnC displayed the greatest reduction in cell motility (p < 0.05). The various mouth rinses examined differentially altered the expression of growth factor transcripts. ZnC particularly enhanced the expression of BMP-2 and FGF-2.</p><p><strong>Conclusion: </strong>ZnC was more cytotoxic and inhibited cell motility to a greater extent than any of the other mouth rinses. Therefore, using ZnC as an alternative to CHX could potentially have negative effects on wound healing after periodontal surgery. However, further investigation is required to confirm the clinical relevance of these in vitro findings.</p><p><strong>Plain language summary: </strong>One type of zinc-based mouth rinse designed to replace chlorhexidine (often prescribed after oral surgeries) demonstrated the greatest oral cell death and reduction in cell movement when compared to other zinc-based mouth rinses. These zinc-based mouth rinses also reduced the amounts of proteins involved in regulating inflammation, potentially reducing the destruction of bone holding the teeth in place. They also changed the amounts of several molecules involved in tissue healing. It is unknown if this will speed or slow the healing of the soft tissues of the mouth.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficiency of oral keratinized gingiva detection and measurement based on convolutional neural network. 基于卷积神经网络的口腔角化牙龈检测和测量效率

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-15 DOI: 10.1002/JPER.24-0151

Gokce Aykol-Sahin, Ozgun Yucel, Nihal Eraydin, Gonca Cayir Keles, Umran Unlu, Ulku Baser

<p><strong>Background: </strong>With recent advances in artificial intelligence, the use of this technology has begun to facilitate comprehensive tissue evaluation and planning of interventions. This study aimed to assess different convolutional neural networks (CNN) in deep learning algorithms to detect keratinized gingiva based on intraoral photos and evaluate the ability of networks to measure keratinized gingiva width.</p><p><strong>Methods: </strong>Six hundred of 1200 photographs taken before and after applying a disclosing agent were used to compare the neural networks in segmenting the keratinized gingiva. Segmentation performances of networks were evaluated using accuracy, intersection over union, and F1 score. Keratinized gingiva width from a reference point was measured from ground truth images and compared with the measurements of clinicians and the DeepLab image that was generated from the ResNet50 model. The effect of measurement operators, phenotype, and jaw on differences in measurements was evaluated by three-factor mixed-design analysis of variance (ANOVA).</p><p><strong>Results: </strong>Among the compared networks, ResNet50 distinguished keratinized gingiva at the highest accuracy rate of 91.4%. The measurements between deep learning and clinicians were in excellent agreement according to jaw and phenotype. When analyzing the influence of the measurement operators, phenotype, and jaw on the measurements performed according to the ground truth, there were statistically significant differences in measurement operators and jaw (p < 0.05).</p><p><strong>Conclusions: </strong>Automated keratinized gingiva segmentation with the ResNet50 model might be a feasible method for assisting professionals. The measurement results promise a potentially high performance of the model as it requires less time and experience.</p><p><strong>Plain language summary: </strong>With recent advances in artificial intelligence (AI), it is now possible to use this technology to evaluate tissues and plan medical procedures thoroughly. This study focused on testing different AI models, specifically CNN, to identify and measure a specific type of gum tissue called keratinized gingiva using photos taken inside the mouth. Out of 1200 photos, 600 were used in the study to compare the performance of different CNN in identifying gingival tissue. The accuracy and effectiveness of these models were measured and compared to human clinician ratings. The study found that the ResNet50 model was the most accurate, correctly identifying gingival tissue 91.4% of the time. When the AI model and clinicians' measurements of gum tissue width were compared, the results were very similar, especially when accounting for different jaws and gum structures. The study also analyzed the effect of various factors on the measurements and found significant differences based on who took the measurements and jaw type. In conclusion, using the ResNet50 model to identify and measure gum tis

背景：随着人工智能领域的最新进展，该技术的使用已开始促进全面的组织评估和干预规划。本研究旨在评估深度学习算法中的不同卷积神经网络（CNN），以根据口内照片检测角化牙龈，并评估网络测量角化牙龈宽度的能力：方法：使用涂抹揭露剂前后拍摄的 1200 张照片中的 600 张照片来比较神经网络分割角化牙龈的能力。使用准确率、交集大于联合和 F1 分数评估网络的分割性能。根据地面实况图像测量了参考点的角化牙龈宽度，并与临床医生的测量结果和由 ResNet50 模型生成的 DeepLab 图像进行了比较。通过三因素混合设计方差分析（ANOVA）评估了测量操作者、表型和颌骨对测量差异的影响：在比较的网络中，ResNet50区分角化牙龈的准确率最高，达到91.4%。根据颌骨和表型，深度学习和临床医生的测量结果非常一致。在分析测量操作员、表型和颌骨对根据基本真相进行的测量的影响时，测量操作员和颌骨存在显著的统计学差异（p 结论：颌骨和表型的测量结果与基本真相的测量结果存在显著差异，而颌骨和表型的测量结果与基本真相的测量结果存在显著差异：使用 ResNet50 模型进行角化牙龈自动分割可能是辅助专业人员的一种可行方法。白话摘要：随着人工智能（AI）的最新进展，现在有可能利用这项技术来评估组织并全面规划医疗程序。这项研究主要测试不同的人工智能模型，特别是 CNN，利用口腔内拍摄的照片来识别和测量一种特定类型的牙龈组织，即角化牙龈。研究使用了 1200 张照片中的 600 张，以比较不同 CNN 在识别牙龈组织方面的性能。对这些模型的准确性和有效性进行了测量，并与人类临床医生的评分进行了比较。研究发现，ResNet50 模型最准确，91.4% 的时间都能正确识别牙龈组织。在比较人工智能模型和临床医生对牙龈组织宽度的测量结果时，结果非常相似，尤其是在考虑到不同颌骨和牙龈结构的情况下。研究还分析了各种因素对测量结果的影响，并发现测量者和颌骨类型之间存在显著差异。总之，使用 ResNet50 模型自动识别和测量牙龈组织可以成为牙科专业人员的实用工具，既节省时间，又减少了对专业知识的要求。

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引用次数: 0

Quantifying periodontitis-associated oral dysbiosis in tongue and saliva microbiomes—An integrated data analysis 在舌头和唾液微生物组中量化牙周炎相关的口腔菌群失调--综合数据分析。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-15 DOI: 10.1002/JPER.24-0120

Ren Jie Jacob Chew, Kai Soo Tan, Tsute Chen, Nezar Noor Al-Hebshi, Charlene Enhui Goh

<div> <section> <h3> Background</h3> <p>Periodontitis is primarily driven by subgingival biofilm dysbiosis. However, the quantification and impact of this periodontal dysbiosis on other oral microbial niches remain unclear. This study seeks to quantify the dysbiotic changes in tongue and salivary microbiomes resulting from periodontitis by applying a clinically relevant dysbiosis index to an integrated data analysis.</p> </section> <section> <h3> Methods</h3> <p>The National Center for Biotechnology Information (NCBI) database was searched to identify BioProjects with published studies on salivary and tongue microbiomes of healthy and periodontitis subjects. Raw sequence datasets were processed using a standardized bioinformatic pipeline and categorized by their ecological niche and periodontal status. The subgingival microbial dysbiosis index (SMDI), a dysbiosis index originally developed using the subgingival microbiome, was computed at species and genus levels and customized for each niche. Its diagnostic accuracy for periodontitis was evaluated using receiver operating characteristic curves.</p> </section> <section> <h3> Results</h3> <p>Four studies, contributing 328 microbiome samples, were included. At both species and genus levels, periodontitis samples had a higher SMDI, but the differences were only significant for subgingival biofilm and saliva (<i>p </i>< 0.001). However, SMDI showed good diagnostic accuracy for periodontitis status for all three niches (area under curve ranging from 0.76 to 0.90, <i>p </i>< 0.05). The dysbiosis index of subgingival biofilm was positively correlated with saliva consistently (<i>p </i>< 0.001) and with the tongue at the genus level (<i>p </i>= 0.036).</p> </section> <section> <h3> Conclusions</h3> <p>While the impact on the tongue microbiome requires further investigation, periodontitis-associated dysbiosis affects the salivary microbiome and is quantifiable using the dysbiosis index. The diagnostic potential of salivary microbial dysbiosis as a convenient periodontal biomarker for assessing periodontal status has potential public health and clinical applications.</p> </section> <section> <h3> Plain Language Summary</h3> <p>Periodontitis, a severe inflammation of the gums which causes bone loss, is a disease caused by an imbalance of good and bad bacteria under the gums. However, it is unclear how this bacterial imbalance in the gums affects the bacterial balance of other distinct parts of the mo

背景：牙周炎主要是由龈下生物膜菌群失调引起的。然而，牙周菌群失调的量化及其对其他口腔微生物壁龛的影响仍不清楚。本研究试图通过将临床相关的菌群失调指数应用于综合数据分析，量化牙周炎导致的舌头和唾液微生物组的菌群失调变化：方法：对美国国家生物技术信息中心（NCBI）数据库进行检索，以确定已发表的有关健康和牙周炎受试者唾液和舌头微生物组研究的生物项目。原始序列数据集采用标准化的生物信息学管道进行处理，并按其生态位和牙周状况进行分类。龈下微生物菌群失调指数（SMDI）是一种最初利用龈下微生物组开发的菌群失调指数，按种和属水平计算，并为每个生态位定制。利用接收器操作特征曲线评估了该指数对牙周炎的诊断准确性：结果：共纳入了四项研究，提供了 328 份微生物组样本。在物种和菌属水平上，牙周炎样本的 SMDI 都较高，但只有龈下生物膜和唾液的差异显著（p 结论）：虽然对舌头微生物组的影响还需要进一步研究，但牙周炎相关的菌群失调会影响唾液微生物组，并可通过菌群失调指数进行量化。唾液微生物菌群失调作为一种评估牙周状况的方便的牙周生物标志物，具有潜在的公共卫生和临床应用诊断潜力。白话摘要：牙周炎是一种严重的牙龈炎症，会导致骨质流失，是一种由牙龈下好坏细菌失衡引起的疾病。然而，目前还不清楚牙龈中的这种细菌失衡如何影响口腔其他不同部位（如唾液和舌头）的细菌平衡。本研究使用了之前发表的四项研究的细菌数据集，共采集了 328 个细菌样本。使用统一的数据分析工作流程对数据进行了处理，并分别计算了牙龈下、唾液和舌头样本的细菌得分，即龈下微生物菌群失调指数（SMDI）。SMDI 能够区分每个口腔部位的健康和牙周炎，一般来说，牙周炎样本的得分更高，但这种差异仅在牙龈下和唾液中的细菌中显著。唾液得分也与牙龈下细菌一致相关。这项研究表明，与牙周炎相关的细菌失衡不仅存在于牙龈下的口腔部位，尤其是唾液中。因此，唾液细菌可用作评估牙龈疾病的便捷生物标志物，具有潜在的公共卫生和临床应用价值。

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引用次数: 0

In vivo experimental study comparing alveolar ridge preservation versus guided bone regeneration after unassisted socket healing at intact and damaged sites in narrow alveolar ridges. 在窄牙槽脊的完整和受损部位进行无辅助牙槽龛愈合后，比较牙槽脊保留与引导骨再生的体内实验研究。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-15 DOI: 10.1002/JPER.24-0125

Hae Jee Shin, Jin-Young Park, Hsu Kuo Tien, Franz-Josef Strauss, Jae-Kook Cha, Jung-Seok Lee

Background: To compare bone regeneration and dimensional alteration of alveolar ridge at intact and damaged extraction sockets after alveolar ridge preservation (ARP) and implant placement versus unassisted socket healing followed by guided bone regeneration (GBR) with simultaneous implant placement.

Methods: In 6 beagle dogs, 3 types of extraction sockets in the mandible were created: (1) intact sockets, (2) 1-wall defect sockets and (3) 2-wall defect sockets. The sockets were allocated to undergo either (1) ARP and implant placement 8 weeks later (ARP group) or (2) GBR with simultaneous implant placement after 8 weeks of unassisted socket healing (GBR group). After an additional healing period of 8 weeks, bone regeneration and dimensional changes were evaluated radiographically and histologically.

Results: GBR showed superior bone formation and greater bone gains compared to ARP, regardless of the initial extraction-socket configuration. Although ARP maintained the preexisting alveolar ridge dimensions, peri-implant bone defects were still detected at 8 weeks of follow-up. Histomorphometric analyses confirmed that GBR increased dimensions of the alveolar ridge compared to baseline, and the augmentation and bone regeneration were greater with GBR than with ARP.

Conclusion: Early implant placement with ARP can mitigate alveolar ridge changes in the narrow alveolar ridge. However, early implant placement with simultaneous GBR creates the conditions for enhanced bone regeneration around the implant and greater ridge augmentation compared to ARP, irrespective of the extraction-socket configuration.

背景：目的：比较牙槽嵴保留（ARP）和种植体植入后，完整拔牙窝和受损拔牙窝的骨再生和牙槽嵴的尺寸变化，以及无辅助拔牙窝愈合后引导骨再生（GBR）并同时植入种植体的情况：在 6 只小猎犬的下颌骨中创建了 3 种类型的拔牙套槽：(1) 完整套槽；(2) 1 壁缺损套槽；(3) 2 壁缺损套槽。这些基台被分配为：(1) ARP，8 周后植入种植体（ARP 组）；(2) GBR，8 周无辅助基台愈合后同时植入种植体（GBR 组）。再经过 8 周的愈合期后，对骨再生和尺寸变化进行影像学和组织学评估：结果：与 ARP 相比，GBR 显示出更优越的骨形成和更大的骨增量，与最初的拔牙窝结构无关。虽然ARP保持了原有的牙槽嵴尺寸，但在8周的随访中仍发现种植体周围有骨缺损。组织形态计量学分析证实，与基线相比，GBR增加了牙槽嵴的尺寸，而且GBR的增量和骨再生效果比ARP更好：结论：在牙槽嵴狭窄的情况下，早期植入种植体并同时植入 ARP 可以缓解牙槽嵴的变化。然而，与 ARP 相比，早期种植体植入同时进行 GBR 可为增强种植体周围的骨再生和牙槽嵴增生创造条件，而与拔牙窝的结构无关。

{"title":"In vivo experimental study comparing alveolar ridge preservation versus guided bone regeneration after unassisted socket healing at intact and damaged sites in narrow alveolar ridges.","authors":"Hae Jee Shin, Jin-Young Park, Hsu Kuo Tien, Franz-Josef Strauss, Jae-Kook Cha, Jung-Seok Lee","doi":"10.1002/JPER.24-0125","DOIUrl":"https://doi.org/10.1002/JPER.24-0125","url":null,"abstract":"<p><strong>Background: </strong>To compare bone regeneration and dimensional alteration of alveolar ridge at intact and damaged extraction sockets after alveolar ridge preservation (ARP) and implant placement versus unassisted socket healing followed by guided bone regeneration (GBR) with simultaneous implant placement.</p><p><strong>Methods: </strong>In 6 beagle dogs, 3 types of extraction sockets in the mandible were created: (1) intact sockets, (2) 1-wall defect sockets and (3) 2-wall defect sockets. The sockets were allocated to undergo either (1) ARP and implant placement 8 weeks later (ARP group) or (2) GBR with simultaneous implant placement after 8 weeks of unassisted socket healing (GBR group). After an additional healing period of 8 weeks, bone regeneration and dimensional changes were evaluated radiographically and histologically.</p><p><strong>Results: </strong>GBR showed superior bone formation and greater bone gains compared to ARP, regardless of the initial extraction-socket configuration. Although ARP maintained the preexisting alveolar ridge dimensions, peri-implant bone defects were still detected at 8 weeks of follow-up. Histomorphometric analyses confirmed that GBR increased dimensions of the alveolar ridge compared to baseline, and the augmentation and bone regeneration were greater with GBR than with ARP.</p><p><strong>Conclusion: </strong>Early implant placement with ARP can mitigate alveolar ridge changes in the narrow alveolar ridge. However, early implant placement with simultaneous GBR creates the conditions for enhanced bone regeneration around the implant and greater ridge augmentation compared to ARP, irrespective of the extraction-socket configuration.</p>","PeriodicalId":16716,"journal":{"name":"Journal of periodontology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peri-implantitis induction and resolution around zirconia versus titanium implants 氧化锆与钛种植体周围的种植体周围炎诱导与缓解。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-14 DOI: 10.1002/JPER.23-0573

Kaleb C. Esplin, Yi-Wen Tsai, Kathryn Vela, Anibal Diogenes, Lea El Hachem, Archontia Palaiologou, David L. Cochran, Georgios A. Kotsakis

Background

This study compared titanium and zirconia implant ligature-induced peri-implant defect progression and response to regenerative surgical intervention.

Methods

Eight tissue-level endosseous implants were placed in 6 mixed-breed foxhounds, with 2 zirconia and 2 titanium alternating in each hemimandible. Cotton ligatures were placed subgingivally for 16 weeks followed by 8 weeks of spontaneous progression. Standardized radiographs were captured every 2 weeks to evaluate the rate of bone loss. Regenerative surgery was performed utilizing water-jet decontamination, enamel matrix derivative, and locally harvested autogenous bone. After 16 weeks of healing, final radiographic bone levels as well as probing depths, recession, and clinical attachment levels were assessed.

Results

All 48 implants integrated successfully. The final average post-ligature radiographic defects were 2.88 and 3.05 mm for titanium and zirconia implants, respectively. There was no significant difference between materials in the rate of radiographic bone loss (p = 0.09). Following regenerative surgery, the total average amount of radiographic bone gain was 1.41 and 1.20 mm for titanium and zirconia, respectively. The percentage of defect fill was 51.56% and 37.98% (p = 0.03) for titanium and zirconia, respectively. Inter-group differences were minimal for clinical parameters at the time of sacrifice including periodontal pocket depths (p = 0.81), recession (p = 0.98), or clinical attachment levels (p = 0.51).

Conclusions

No significant difference was found in the rate of peri-implant defect development between titanium and zirconia implants. Both materials gained significant radiographic bone following regenerative surgery with significantly greater defect percentage fill in titanium implants. The final clinical parameters were similar in both groups.

背景：本研究比较了钛和氧化锆种植体结扎引起的种植体周围缺损进展和对再生手术干预的反应：本研究比较了钛和氧化锆种植体结扎引起的种植体周围缺损进展以及对再生手术干预的反应：方法：在 6 只混种猎狐犬中植入 8 个组织水平的骨内种植体，每个半颌交替植入 2 个氧化锆和 2 个钛种植体。在龈下放置棉花结扎带 16 周，然后自发进行 8 周。每 2 周拍摄一次标准化 X 光片，以评估骨质流失率。利用喷水去污、釉质基质衍生物和当地采集的自体骨进行再生手术。愈合16周后，对最终的放射骨水平、探查深度、后退和临床附着水平进行评估：结果：所有 48 个种植体均成功整合。钛和氧化锆种植体最终的平均结扎后影像学缺损分别为 2.88 毫米和 3.05 毫米。不同材料的骨质流失率无明显差异（P = 0.09）。再生手术后，钛和氧化锆材料的放射骨增量总平均值分别为 1.41 毫米和 1.20 毫米。钛和氧化锆的缺损填充率分别为 51.56% 和 37.98%（p = 0.03）。牺牲时的临床参数，包括牙周袋深度（p = 0.81）、牙周退缩（p = 0.98）或临床附着水平（p = 0.51），组间差异极小：结论：钛和氧化锆种植体在种植体周围缺损发展率方面没有明显差异。两种材料在再生手术后都获得了明显的放射性骨量，但钛种植体的缺损填充率明显更高。两组的最终临床参数相似。

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引用次数: 0

Subgingival microbial profiles in pre- and postmenopausal women: Associations with serum estradiol levels 绝经前后妇女的龈下微生物概况：与血清雌二醇水平的关系。

IF 4.2 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of periodontology

Pub Date : 2024-07-14 DOI: 10.1002/JPER.24-0267

Nil Yakar, Busra Yilmaz, Gulnur Emingil, Tsute Chen, Guven Ozdemir, Alpdogan Kantarci

<div> <section> <h3> Background</h3> <p>Subgingival dental plaque is an ecosystem playing a key role in supporting both oral health and systemic health. Menopause-related changes have the potential to disrupt its balance, which is crucial to postmenopausal well-being. Our study explored how circulating estradiol levels correlate with subgingival microbial composition using checkerboard DNA-DNA hybridization in premenopausal and postmenopausal women. We also demonstrated that combining this method with 16S ribosomal RNA (rRNA) sequencing insights remains valuable for examining subgingival ecology.</p> </section> <section> <h3> Methods</h3> <p>We assessed 40 bacterial species in 77 premenopausal and 81 postmenopausal women using checkerboard DNA-DNA hybridization and measured serum estradiol with enzyme-linked immunosorbent assay (ELISA). Women were categorized by subgingival dysbiosis severity using a modified Subgingival Microbial Dysbiosis Index (mSMDI). Six women from each normobiotic and dysbiotic subgroup across premenopausal and postmenopausal women underwent 16S rRNA sequencing analysis.</p> </section> <section> <h3> Results</h3> <p>DNA checkerboard analysis revealed that most observed variability in individual bacterial proportions is associated with periodontitis. Two species, Leptotrichia buccalis and Streptococcus constellatus, exhibited differences related to estradiol levels within the premenopausal group (<i>p</i> = 0.055 and <i>p</i> = 0.009, respectively). 16S rRNA sequencing confirmed the mSMDI's validity in categorizing normobiotic and dysbiotic states. Menopausal status was not associated with a dysbiotic shift in the subgingival microbiome despite significantly more attachment loss in postmenopausal compared to premenopausal women.</p> </section> <section> <h3> Conclusions</h3> <p>Our results indicate that decreased estradiol levels or increased attachment loss during menopause are not associated with changes in species abundance or dysbiotic shifts in women. The mSMDI may be a useful tool for classifying subgingival ecology based on its normobiotic or dysbiotic inclination.</p> </section> <section> <h3> Plain Language Summary</h3> <p>The microorganisms in the oral cavity, particularly those around the teeth and gums, form a complex community known as subgingival plaque. This ecosystem is crucial for maintaining both gum health and systemic health. While disease-related (dysbiotic) subgingival plaque causes gum disease (periodontitis), periodontitis further sustains a dysbiotic subgingival plaque microbial environment. Factors such

背景：龈下牙菌斑是一个生态系统，在支持口腔健康和全身健康方面发挥着关键作用。与更年期有关的变化有可能破坏其平衡，而这对绝经后的健康至关重要。我们的研究利用棋盘式 DNA-DNA 杂交技术探讨了绝经前和绝经后妇女体内循环雌二醇水平与龈下微生物组成的相关性。我们还证明，将该方法与 16S 核糖体 RNA（rRNA）测序相结合，对研究龈下生态仍有价值：方法：我们使用棋盘式 DNA-DNA 杂交法评估了 77 名绝经前妇女和 81 名绝经后妇女的 40 种细菌，并使用酶联免疫吸附测定法（ELISA）测量了血清雌二醇。使用改良的龈下微生物菌群失调指数 (mSMDI) 根据龈下微生物菌群失调的严重程度对妇女进行分类。在绝经前和绝经后妇女中，每个正常菌群和菌群失调亚组各有六名妇女接受了 16S rRNA 测序分析：结果：DNA棋盘分析表明，观察到的细菌个体比例变化大多与牙周炎有关。在绝经前组别中，有两种细菌，即口腔钩端螺旋体和星座链球菌，表现出与雌二醇水平相关的差异（分别为 p = 0.055 和 p = 0.009）。16S rRNA 测序证实了 mSMDI 在划分正常生物状态和生物失调状态方面的有效性。绝经状态与龈下微生物群中的菌群失调无关，尽管与绝经前相比，绝经后妇女的附着物脱落明显增多：我们的研究结果表明，绝经期间雌二醇水平的降低或附着物脱落的增加与女性物种丰度的变化或菌群失调无关。mSMDI 可能是一种有用的工具，可根据正常生物或菌群失调倾向对龈下生态进行分类。

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引用次数: 0