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Photooxidation of Polystyrene into High-Value Chemicals 将聚苯乙烯光氧化成高价值化学品
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-05 DOI: 10.1002/ejoc.202401109
Shusheng Jiang, Yunhan Chen, Yahao Huang, Peng Hu
Plastics play a crucial role in the survival and advancement of human civilization. However, the increasing challenge of plastic pollution presents significant obstacles. Disposal methods such as incineration and landfilling result in substantial resource wastage and pose potential environmental hazards. The slow progress in recycling and reusing waste plastics hinders their industrial application and effective response to environmental crises. Photocatalysis offers promising solutions for the future of plastic recycling, particularly with the recent increase in photocatalytic degradation methods for polystyrene (PS). This review provides a comprehensive overview of the latest advancements in the photooxidation of PS into high-value chemicals.
塑料在人类文明的生存和进步中发挥着至关重要的作用。然而,日益严峻的塑料污染挑战带来了巨大障碍。焚烧和填埋等处理方法造成大量资源浪费,并对环境造成潜在危害。废塑料的回收和再利用进展缓慢,阻碍了其工业应用和有效应对环境危机。光催化技术为未来的塑料回收利用提供了前景广阔的解决方案,尤其是最近聚苯乙烯(PS)的光催化降解方法不断增加。本综述全面概述了将聚苯乙烯光氧化成高价值化学品的最新进展。
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引用次数: 0
Palladium-Catalyzed Domino Synthesis of Sulfone-Containing 1,3-Enynes from Simple Alkynes and Sulfonyl Iodides 钯催化的由简单炔烃和磺酰基碘化物合成含砜 1,3-Enynes 的多米诺反应
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-05 DOI: 10.1002/ejoc.202401028
Jing Wang, Jianwei Wang, Jun Ying
A palladium-catalyzed domino radical sulfonylation and alkynylation of simple alkynes has been developed for the rapid construction of privileged scaffolds containing sulfone and 1,3-enyne motifs. The reaction of sulfonyl iodide with simple alkynes proceeded smoothly under mild conditions to afford a variety of sulfone-containing 1,3-enynes in good yields and with excellent selectivities.
我们开发了一种钯催化的多米诺自由基磺酰化和简单炔烃的炔烃化方法,用于快速构建含有砜和 1,3-炔基团的特异性支架。磺酰基碘与简单炔烃的反应在温和的条件下顺利进行,以良好的产率和优异的选择性得到了多种含砜的 1,3-炔烃。
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引用次数: 0
Synthesis, Structure, Spectral and Redox Properties of Phenoxazine Embedded Heteroporphyrins 嵌入吩嗪的杂卟啉的合成、结构、光谱和氧化还原特性
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-05 DOI: 10.1002/ejoc.202401068
Neha Tripathi, Mangalampalli Ravikanth
A series of phenoxazine embedded heteroporphyrins containing one phenoxazine, two pyrroles and one heterocycle, such as furan, thiophene, selenophene and telluorophene, connected through four meso carbon atoms were synthesized by condensing one equivalent of phenoxazine-based tripyrrane with one equivalent of the appropriate 2,5-bis(hydroxymethyl-p-tolyl) heterocycle under acid-catalyzed conditions, and their structure, spectral and electrochemical properties were compared with those of previously reported phenothiazine embedded heteroporphyrins. The X-ray crystal structure of the phenoxazine embedded selenoporphyrin revealed that the selenophene ring, which is opposite phenoxazine moiety, points outward from the macrocyclic core, and the phenoxazine unit deviated by an angle of 39.47° from the mean plane defined by the four meso carbons atoms. The replacement of the phenothiazine unit in phenothiazine embedded heteroporphyrins with a phenoxazine unit led to significant alteration of the electronic properties of the macrocycles, as reflected in their spectral and electrochemical properties. The absorption spectra of phenoxazine embedded heteroporphyrins showed bathochromically shifted absorption bands, hypsochromically shifted fluorescence bands with decent quantum yields, more facile oxidation and more difficult reduction as compared to the corresponding phenothiazine embedded heteroporphyrins. DFT and TD-DFT studies were in support of the experimental observations.
在酸催化条件下,将一个等效的吩嗪基三吡喃与一个等效的适当的 2.5-双(羟甲基-对甲苯基)杂环缩合,合成了一系列含有一个吩嗪、两个吡咯和一个杂环(如呋喃、噻吩、硒吩和碲吩)的吩嗪内嵌杂卟啉,并将它们的结构、光谱和电化学性质与之前报道的吩噻嗪内嵌杂卟啉进行了比较、在酸催化条件下,将一个等量的吩嗪基三吡喃与一个等量的适当的 2、5-双(羟甲基-对甲苯基)杂环缩合合成了吩嗪基三吡喃和碲吩,并将它们的结构、光谱和电化学性质与之前报道的吩噻嗪嵌入杂卟啉进行了比较。嵌入吩噁嗪的硒卟啉的 X 射线晶体结构显示,与吩噁嗪分子相对的硒吩环指向大环核心的外侧,吩噁嗪单元与四个中碳原子定义的平均平面偏离 39.47° 角。用吩噁嗪单元取代吩噻嗪嵌入杂卟啉中的吩噻嗪单元会显著改变大环的电子特性,这反映在它们的光谱和电化学特性上。与相应的吩噻嗪内嵌杂卟啉相比,吩嗪内嵌杂卟啉的吸收光谱显示了浴色偏移的吸收带和次浴色偏移的荧光带,量子产率较高,更容易氧化和更难还原。DFT 和 TD-DFT 研究证实了实验观察结果。
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引用次数: 0
Palladium-Catalyzed C4,C5-Diarylation of Isoxazole-3-carboxylate by Double C–H Bond Functionalization 钯催化双 C-H 键官能化异恶唑-3-羧酸酯的 C4、C5-二芳基化反应
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-04 DOI: 10.1002/ejoc.202401036
Rabeb Ben Romdhane, Linhao Liu, Ridha Ben Salem, Henri Doucet
The Pd-catalyzed C4-arylation of 3,5-disubstituted isoxazoles via C-H bond functionalization has been largely described. By contrast, the reactivity of isoxazoles in C-H bond functionalization with both unsubstituted C4 and C5 positions remains largely unexplored. Herein, we report on the reactivity in Pd-catalyzed double C-H bond arylation of an isoxazole with unsubstituted C4 and C5 positions. Conditions for the palladium-catalyzed direct C4,C5-diarylation of ethyl isoxazole-3-carboxylate using aryl bromides as the aryl source are reported. This procedure tolerates several useful substituents on the aryl bromide such as nitrile, acetyl, formyl, benzoyl, alkoxycarbonyl, chloro, fluoro, trifluoromethyl, trifluoromethoxy, cyanomethyl,tertbutyl and methoxy at para- and meta-positions. Conversely, with ortho-substituted aryl bromides, mixtures of mono- and di-arylated isoxazoles were generally obtained. This methodology provides a simple one pot access to a wide variety of C4,C5-diarylated isoxazoles from commercially available substrates allowing to modify easily their biological properties.
通过 C-H 键官能化,Pd 催化 3,5 二甲基异噁唑的 C4 芳基化反应已被广泛描述。相比之下,异噁唑与未取代的 C4 和 C5 位的 C-H 键官能化反应性在很大程度上仍未得到探索。在此,我们报告了钯催化未取代 C4 和 C5 位的异噁唑双 C-H 键芳基化的反应性。报告了以芳基溴化物为芳基源,钯催化异噁唑-3-羧酸乙酯直接发生 C4、C5-二芳基化反应的条件。该过程可容忍芳基溴上的几个有用取代基,如腈、乙酰基、甲酰基、苯甲酰基、烷氧羰基、氯、氟、三氟甲基、三氟甲氧基、氰甲基、叔丁基和对位和偏位的甲氧基。相反,使用正交取代的芳基溴,通常会得到单芳基和二芳基异噁唑的混合物。这种方法提供了一种简单的一锅式方法,可从市售底物中获得多种 C4、C5-二芳基化异噁唑,从而轻松改变它们的生物特性。
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引用次数: 0
Chiral Secondary Phosphine Oxide Ligands in Asymmetric Ni–Al Bimetallic Catalysis 不对称 Ni-Al 双金属催化中的手性仲膦氧化物配体
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-02 DOI: 10.1002/ejoc.202401000
Mengying Xu, Weiwei Xu, Mengchun Ye
Ligands play a key role in asymmetric transition-metal catalysis. Among reported chiral ligands, readily available and air-stable secondary phosphine oxide ligands are unique and have aroused wide interest in Ni–Al bimetallic catalysis, since they can act as bifunctional ligands to ligate two metals for stronger bimetallic synergism, greatly enhancing reactivity and selectivity. Hence, in this mini review we will focus on secondary phosphine oxides and their applications in asymmetric Ni-Al bimetallic catalysis.
配体在不对称过渡金属催化中起着关键作用。在已报道的手性配体中,易于获得且在空气中稳定的仲膦氧化物配体是独一无二的,并在镍铝双金属催化中引起了广泛的兴趣,因为它们可以作为双功能配体连接两种金属,从而产生更强的双金属协同作用,大大提高反应活性和选择性。因此,在这篇小型综述中,我们将重点介绍仲膦氧化物及其在不对称镍铝双金属催化中的应用。
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引用次数: 0
Synthesis and Properties of 6-Oxazaaceanthrylenes 6-Oxazaaceanthrylenes 的合成与特性
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-01 DOI: 10.1002/ejoc.202401045
Jan Radolko, Ha N Do, Peter Ehlers, Alexander Villinger, Peter Langer
6‑Oxazaaceanthrylenes have been synthesized for the first time via a selective SNAr reaction or Ullmann-coupling of phenols, followed by a C-H activation reaction. The reaction has been carefully optimized and permits the selective synthesis of N,O-doped aceanthrylenes in moderate to excellent yields and tolerate various functional groups. The aromatic behavior of the hitherto unknown heterocyclic scaffold has been further analyzed by NICS and NICS2BC calculations.
通过选择性 SNAr 反应或苯酚的乌尔曼偶联反应,然后进行 C-H 活化反应,首次合成了 6-氧杂氮杂蒽。该反应经过精心优化,可以选择性地合成 N,O-掺杂的洋蒽,产率从中等到极好,并能耐受各种官能团。通过 NICS 和 NICS2BC 计算,进一步分析了迄今未知杂环支架的芳香行为。
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引用次数: 0
Convergent Synthesis of Antitumor Aplysiatoxin Derivatives Based on a Combination of Ring-closing and Cross Metathesis 基于闭环和交叉复分解的抗肿瘤阿立哌唑毒素衍生物的聚合合成
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-01 DOI: 10.1002/ejoc.202401074
Mako Aoki, Hiroto Takarada, Jumpei Maki, Takumi Kobayashi, Chihiro Tsukano, Kazuhiro Irie
We investigated a convergent synthesis of aplysiatoxin analogs based on a combination of ring-closing and cross metathesis. The route provided four analogs (3a–d) with different side chains to determine the CH/π interaction with protein kinase C (PKC)-C1 domains. Biochemical evaluation revealed that a naphthol moiety did not improve binding to PKC-C1 domains, suggesting that the hydrogen bonding of the hydroxy group with the PKC-C1 domains may be more important than the CH/π interaction.
我们研究了一种基于闭环反应和交叉复分解反应的芹菜毒素类似物的聚合合成方法。该路线提供了四种具有不同侧链的类似物(3a-d),以确定 CH/π 与蛋白激酶 C (PKC)-C1 结构域的相互作用。生化评估显示,萘酚分子并没有改善与 PKC-C1 结构域的结合,这表明羟基与 PKC-C1 结构域的氢键结合可能比 CH/π 相互作用更为重要。
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引用次数: 0
Developments in the Construction of Benzo[b]thiophenes from 2-Alkynylthioanisoles by Electrophilic and Radical Cyclization Reactions 通过亲电和自由基环化反应从 2-炔基硫代苯甲醚构建苯并[b]噻吩的研究进展
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-01 DOI: 10.1002/ejoc.202401059
Tianbo Shang, Chao Ma, Mengyu Xie, Tao Cai, Yuzhen Gao
Benzo[b]thiophene moieties are important skeletons which have been widely found in many natural products, pharmaceuticals, as well as functionalized materials. 2-Alkynylthioanisoles, a class of bifunctional compounds bearing methylthio and alkynyl groups, are easily accessible from Pd-catalyzed Sonogashira coupling between 2-halothioanisoles and terminal alkynes, which have been widely employed as synthons in the construction of benzo[b]thiophenes through an electrophilic or a radical pathway. This review summarizes the related developments with a particular focus on the reaction mechanism. We hope it will help in future research in this area and believe that with the discovery of new catalytic systems, the industrial synthesis of benzo[b]thiophenes from 2-alkynylthioanisoles will be achieved soon.
苯并[b]噻吩是一种重要的骨架,广泛存在于许多天然产品、药物和功能化材料中。2-炔基硫代苯甲醚是一类带有甲硫基和炔基的双官能化合物,很容易通过钯催化 2-卤代苯甲醚和末端炔基之间的 Sonogashira 偶联获得,这些化合物已被广泛用作通过亲电或自由基途径构建苯并[b]噻吩的合成物。本综述总结了相关的研究进展,尤其侧重于反应机理。我们希望这篇综述有助于今后该领域的研究,并相信随着新催化体系的发现,很快就能实现从 2-炔基硫代苯甲醚合成苯并[b]噻吩的工业化生产。
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引用次数: 0
Flowing Forward: Continuous Synthesis of and with Ionic Liquids 向前流动:离子液体的连续合成和使用离子液体的连续合成
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-01 DOI: 10.1002/ejoc.202400917
Kristof Stagel, Katharina Bica-Schröder
Recent advances in the continuous synthesis of ionic liquids and SILP-assisted continuous processes are reviewed in this manuscript. These catalyst frameworks still provide an attractive strategy in many organic transformations and provide a suitable tool for designing new synthetic approaches. This review focuses on recent developments in the research area from 2016 up until today.
本手稿回顾了离子液体连续合成和 SILP 辅助连续工艺的最新进展。这些催化剂框架在许多有机转化中仍然是一种极具吸引力的策略,并为设计新的合成方法提供了合适的工具。本综述侧重于 2016 年至今该研究领域的最新进展。
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引用次数: 0
Transition‐Metal‐Catalyzed Construction of Axially Chiral Carbonyl Compounds 过渡金属催化构建轴向手性羰基化合物
IF 2.8 3区 化学 Q2 CHEMISTRY, ORGANIC Pub Date : 2024-11-01 DOI: 10.1002/ejoc.202400995
Yu Yan, Min Pan, Jialin Ming, Jun-Ping Yue, Xiao-Wang Chen, Yong-Yuan Gui, Da-Gang Yu
The synthesis of axially chiral carbonyl compounds has attracted considerable interest in organic synthesis due to their prevalence in natural products and pharmaceuticals, as well as their utility in material science and catalysis. Transition‐metal‐catalyzed approaches have become powerful tools for their construction, offering high efficiency, selectivity, and versatility among the various methods developed. This concept aims to provide a comprehensive overview of recent advances in the transition‐metal‐catalyzed asymmetric synthesis of axially chiral carbonyl compounds, integrating scattered work with different catalytic systems. This feature concept is divided into four types of reactions based on the strategies employed: cross‐coupling reactions, cycloaddition reactions, desymmetrization reactions, and other C‒H activation reactions.
由于轴向手性羰基化合物在天然产品和药物中的普遍存在,以及在材料科学和催化领域的实用性,它们的合成在有机合成中引起了极大的兴趣。过渡金属催化方法已成为构建手性羰基化合物的有力工具,在已开发的各种方法中具有高效性、选择性和多功能性。本概念旨在全面概述过渡金属催化轴向手性羰基化合物不对称合成的最新进展,整合不同催化体系的分散工作。这一专题概念根据所采用的策略分为四种反应类型:交叉耦合反应、环化反应、非对称反应和其他 C-H 活化反应。
{"title":"Transition‐Metal‐Catalyzed Construction of Axially Chiral Carbonyl Compounds","authors":"Yu Yan, Min Pan, Jialin Ming, Jun-Ping Yue, Xiao-Wang Chen, Yong-Yuan Gui, Da-Gang Yu","doi":"10.1002/ejoc.202400995","DOIUrl":"https://doi.org/10.1002/ejoc.202400995","url":null,"abstract":"The synthesis of axially chiral carbonyl compounds has attracted considerable interest in organic synthesis due to their prevalence in natural products and pharmaceuticals, as well as their utility in material science and catalysis. Transition‐metal‐catalyzed approaches have become powerful tools for their construction, offering high efficiency, selectivity, and versatility among the various methods developed. This concept aims to provide a comprehensive overview of recent advances in the transition‐metal‐catalyzed asymmetric synthesis of axially chiral carbonyl compounds, integrating scattered work with different catalytic systems. This feature concept is divided into four types of reactions based on the strategies employed: cross‐coupling reactions, cycloaddition reactions, desymmetrization reactions, and other C‒H activation reactions.","PeriodicalId":167,"journal":{"name":"European Journal of Organic Chemistry","volume":"26 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
European Journal of Organic Chemistry
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