Journal of Pharmacopolium最新文献

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IDENTIFIKASI TARGET RESEPTOR SENYAWA 10,11-DIHIDROERISODIN SEBAGAI KANDIDAT ANTIKANKER SECARA IN SILICO 鉴定目标化合物1011 -淋巴细胞素为硅胶抗癌候选人

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/JOP.V1I1.393

Srie Rezeki Nur Endah

Cancer is one of the most feared diseases and is considered the leading cause of death worldwide. Generally, cancer drugs are synthetic drugs with relatively more expensive prices and have harmful side effects, so many people turn to traditional medicine, for example by utilizing herbal medicine. Erythrina poeppigiana is one of the plants that can be used as a medicinal plant containing 10.11-dihidroerisodin compounds that are useful anticancer etnofarmakologi. The purpose of this study was to identify the target of 10,11 dihydroerisodin receptor compound as an insertiico anticancer candidate. The pure isolate was then tested physicochemically MS, UV-Vis, IR, 13C-NMR, 1H-NMR, to obtain the structure of 10.11-dihydroerisodin alkaloid compound which then to target receptors in silico. From the results of the study it was found that 10.11-dihydroerisodin compound can work on the Serine / threonine-protein kinase Chk1 receptor that serves as an anti-cancer candidate. Keywords : 10,11-dihidroerisodin, anti-cancer, target receptors

癌症是最可怕的疾病之一，被认为是世界范围内死亡的主要原因。一般来说，抗癌药物是合成药物，价格相对昂贵，并且有有害的副作用，所以很多人转向传统药物，例如使用草药。赤藓(Erythrina poeppigiana)是一种含有抗癌药理活性物质10.11-二氢异黄酮的药用植物。本研究的目的是确定10,11二氢蛇毛素受体化合物的靶点，作为一种插入抗癌候选物。对分离物进行理化MS、UV-Vis、IR、13C-NMR、1H-NMR等测试，得到10.11-二氢蛇毛素生物碱化合物的结构，并将其定位于硅靶受体。从研究结果中发现，10.11-二氢蛇毛素化合物可以作用于丝氨酸/苏氨酸蛋白激酶Chk1受体，作为抗癌候选者。关键词:10,11-二氢苯胺，抗癌，靶受体

引用次数: 1

IDENTIFIKASI BAKTERI POTENSIAL PADA FASE PEMATANGAN KOMPOS MANUR 在堆肥成熟阶段识别潜在的细菌

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/jop.v1i1.390

Fenti Fatmawati

Pengomposan merupakan salah satu sumber dalam mencari mikroorganisme potensial penghasil enzim Selama proses pengomposan, terjadi perubahan komunitas mikroorganisme yang disebabkan oleh beberapa faktor seperti perubahan suhu. Proses pengomposan pada penelitan ini terbagi menjadi 5 tahap pengomposan yaitu fasa inisiasi/ awal pengomposan (suhu pengomposan 28oC), mesofilik pertama (suhu 50 oC), termofilik (suhu 55 oC), mesofilik kedua (suhu 50 oC) dan fasa pematangan (suhu 37 oC). Tujuan dari penelitian ini adalah untuk mengidentifikasi bakteri potensial yang dapat menghasilkan enzim amilase, selulase, xilanase dan lipase pada fase pematangan/ fase akhir pada proses pengomposan manur sapi. Dari hasil penelitian didapatkan bakteri F5A yaitu bakteri potensial dari hasil fase pematangan/fase akhirkompos manur sapi. Bakteri ini sangat potensial karena memiliki aktivitas amilase, selulase, xilanase dan lipase. Dari hasil analisis filogenetik diketahui bahwa bakteri F3A memiliki homologi terdekat dengan Viridibacillus arenosi dengan kemiripan 98%. Kata Kunci: Amilase, Lipase, Selulase, Xilanase, Viridibacillus arenosi

堆肥是在堆肥过程中寻找可能产生酶的微生物的来源之一，微生物群落的变化是由温度变化等因素引起的。研究的结果将其分为5个种植阶段，即初始化相位(共28oC)、第一种中位数(温度50 oC)、温度计(温度55 oC)、第二种中位数(温度50 oC)和成熟阶段(温度37摄氏度)。这项研究的目的是确定一种潜在的细菌，这种细菌可以在酶、纤维化、酶和酶的成熟阶段产生淀粉样酶。F5A细菌是一种潜在的成熟阶段/成熟阶段填充牛肉的细菌。这种细菌的潜力在于它有淀粉、纤维化、酶和柠檬酶。根据对纤维遗传学的分析，F3A细菌与真核菌有98%的相似性。关键词:ami酶，Lipase，纤维素，Xilanase, viribacillus arenosi

引用次数: 1

FATTY ACID ANALYSIS OF MARINE MICROALGAE Chlorella Sp. IN MODIFIED MEDIUM USED GAS CRHOMATOGRAPHY-MASS SPECTROMETRY (GC-MS) 改良培养基中海洋微藻小球藻脂肪酸的气相色谱-质谱联用分析

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/JOP.V1I1.389

D. Kurnia

Microalgae is known as a raw materials of pharmaceutical industry, it contains various chemical compounds such as protein, fatty acid, pigments and vitamins. The compound can be use as a basic ingredient of pharmaceutical also can be use as a treatment or prevention agent such as cancer and high cholesterol. Chlorella sp. is a green microalgae which can be found in Indonesia marine area, it also has a high enough of lipid. Compotition of fatty acid from marine microalgae Chlorella sp that cultivated with modification medium has been analyzed. Microalgae culture cultivated with GM 10% as a medium for 8 days. 51,55 L culture produced a 31,0537 gr dry biomass. 31,0537 gr dry biomass Soxhletation produced about 12,8818% w/w oil rendemen. The results of GC-MS analysis, there are 3 types of fatty acids identified in microalgae Chlorella Sp. The composition are palmitic acid (13,34%), linoleic acid (5,39%) and oleic acid (16,40%). Total fatty acid contained is 35,13% Keywords:Chlorella sp, fatty acids, GC-MS.

微藻被称为制药工业的原料，它含有多种化合物，如蛋白质、脂肪酸、色素和维生素。该化合物可作为药物的基本成分，也可作为癌症和高胆固醇的治疗或预防剂。小球藻是一种生长在印度尼西亚海域的绿色微藻，它的脂质也足够高。对改性培养基培养的海洋微藻小球藻脂肪酸组成进行了分析。以10%转基因为培养基培养微藻8天。51,55 L培养产生31,0537 g干生物量。31,0537克干生物质Soxhletation产生约12,8818% w/w的原油。GC-MS分析结果显示，在小球藻中鉴定出3种脂肪酸，组成分别为棕榈酸(13.34%)、亚油酸(5.39%)和油酸(16.40%)。关键词:小球藻，脂肪酸，气相色谱-质谱法。

引用次数: 3

SKRINING AKTIVITAS ANTIBAKTERI FRAKSI EKSTRAK ETANOL KERNEL BIJI BUAH LIMUS (Mangifera foetida Lour.) TERHADAP Staphylococcus aureusDAN Escherichia coli 提取利尿剂果实果实内核的乙醇成分的抗菌活性。杆菌杆菌

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/JOP.V1I1.394

Vera Nurviana

Limus (Mangifera foetida Lour.) Is one of the local Indonesian fruits of the anacardiaceae family. Limus contain secondary metabolites that have pharmacological effects, including the kernel waste of the seeds of the fruit. This study aims to determine the antibacterial activity against Staphylococcus aureus and Escherichia coli on the fraction of kernel seed of limus fruits ethanolic extract in invitro using solid diffusion method with positive control Tetracycline HCl. The extraction process was carried out by maceration method, then fractionation was obtained to obtain the fraction of n-hexane, ethyl acetate fraction and water fraction. Based on the result of the research, the fraction of n-hexane, ethyl acetate fraction, and water fraction of kernel ethanol extract limus fruit seed have antibacterial activity against Staphylococcus aureus and Escherichia coli. The highest activity was shown by fraction of ethyl acetate with minimum killing concentration (KBM) to Staphylococcus aureus was 5% with diameter equal to 4,33 ± 1.17 mm equal to 30,27 μg / mL Tetracycline HCl, and KBM value to Escherichia coli.4% (7.60 ± 0.14) mm equivalent to 26, 04 μg / mL Tetracycline HCl. Keywords: Antibacterial, Staphylococcus aureus, Escherichia coli, Kernel, M. foetida.

柠檬汁(芒果汁)是印尼当地的一种桃科水果。Limus含有次生代谢物，具有药理作用，包括果实种子的核废物。本研究以四环素HCl为阳性对照，采用固体扩散法测定柠檬果乙醇提取物仁籽部分对金黄色葡萄球菌和大肠杆菌的体外抑菌活性。采用浸渍法提取，分馏得到正己烷馏分、乙酸乙酯馏分和水馏分。研究结果表明，正己烷馏分、乙酸乙酯馏分和水馏分对葡萄球菌和大肠杆菌均有抑菌作用。最小杀伤浓度(KBM)为5%(直径为4,33±1.17 mm = 30,27 μg / mL四环素HCl)的乙酸乙酯组分对金黄色葡萄球菌(Staphylococcus aureus)的活性最高，对大肠杆菌的KBM值最高。4%(7.60±0.14)mm，相当于26,04 μg / mL盐酸四环素。关键词:抗菌;金黄色葡萄球菌;大肠杆菌;

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引用次数: 0

ISOLASI ZAT WARNA BARU Monascus purpureus DARI HASIL FERMENTASI PADAT DENGAN BERAS SEBAGAI SUBSTRAT 从以大米为基质发酵的固体中分离出新色球菌

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/JOP.V1I1.391

A. Yuliana

Monascus purpureus is a mold capable of producing pigment as secondary metabolites. Pigments of Monascus purpureus isolated from rice fermented solid known as red yeast rice. This study was conducted toMonascus purpureus know the potential in generating new compounds of pigment produced by solid fermentation process with rice as a substrate. The results indicate insulation compounds and new compounds of pigment Monascus purpureus. Beginning with an analysis of Thin Layer Chromatography (TLC) using the mobile phase n-hexane and ethyl acetate (7:3) with a Rf value obtained was 0.71. Analysis with UV-Vis spectrophotometry against red yeast rice extract aims to determine the maximum wavelength. The results of the analysis of UV-Vis spectrophotometry obtained one peak an absorption at 0.255 with a wavelength of 486 nm which showed that the red pigment monascorubramin compounds in Monascus purpureus. Isolation of Monascus purpureus pigments by Preparative Thin Layer Chromatography (Preparative TLC) using the mobile phase n-hexane and ethyl acetate (7:3). Results isolation pigment Monascus purpureus form of a ribbon that can fluoresces atλ 365 nm UV light with a Rf value obtained was 0.73 were further identification of the molecular weights of compounds Monascus purpureus using HPLC instruments with detectors MS (Mass Spectrometer). The results of LC-MS analysis of a sample INACC-F01 showed a new compound which has a molecular weight of 357.41 and based on the literature that the same compounds with molecular weight is Monascopyridine C which is a derived compound from Monascus red pigment that is monascorubramin and rubropunctamin.

Keywords:Monascus purpureus, pigment, angkak, Preparative TLC, LC-MS.

红曲霉(Monascus purpureus)是一种能够产生色素作为次生代谢产物的霉菌。从大米发酵固体中分离的红曲霉色素称为红曲米。以水稻为底物的固体发酵过程中，紫色红曲霉(toMonascus purpureus)有可能产生新的色素化合物。结果表明，红曲霉色素中含有绝缘化合物和新化合物。采用流动相正己烷和乙酸乙酯(7:3)进行薄层色谱(TLC)分析，得到的Rf值为0.71。用紫外可见分光光度法测定红曲米提取物的最大波长。紫外可见分光光度法分析结果显示，在0.255处有一个峰，波长为486 nm，表明红曲霉中含有红色素单抗红素类化合物。采用流动相正己烷-乙酸乙酯(7:3)制备薄层色谱分离红曲霉色素。结果分离得到的红曲色素呈带状，可在λ 365 nm紫外光下发出荧光，得到的Rf值为0.73，利用HPLC仪器和检测器MS(质谱仪)进一步鉴定了红曲色素化合物的分子量。对INACC-F01样品进行LC-MS分析，发现了一个分子量为357.41的新化合物，根据文献报道，该化合物为红曲霉红素的衍生物Monascopyridine C，即红曲霉红素和红曲霉红素。关键词:红曲霉，色素，安卡，制备TLC, LC-MS

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引用次数: 1

ANALISIS CEMARAN LOGAM BERAT MERKURI DALAM KRIM PEMUTIH WAJAH YANGBEREDAR DIPASAR TRADISIONAL DENGAN METODE SPEKTROFOTOMETRI SERAPANATOM 这是一种利用六烯光谱学方法在传统市场上循环的汞重金属分析

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/jop.v1i1.395

Vinas Anggraeni

Mercury is one of the most dangerous chemicals that is often added to whitening cream. There are many manufacturers or sellers of whitening cream who use mercury in their products even though it is use is prohibited. This research conducted a qualitative and quantitative analysis of mercury on five samples of whitening cream in the traditional market. Qualitative analysis was performed using KI reagent and showed five samples containing mercury. Then, the determination of mercury in the sample by Atomic Absorption Spectrophotometer at a wavelength of 243,7 nm. From the validation result, the regression equation obtained from the calibration curve is Y = 0,016779x - 0,04377 with LOD and LOQ of 2,1552 µg/L and 7,184 µg/L. The accuracy test is indicated by the percent recovery is in the range 88-97% and the precision test is shown with the % RSD value of 0,044-1,57%. The quantitative analysis results of five samples showed that all samples contained mercury levels range from 51,576 ppm to 3886,776 ppm. Keywords:Whitening cream;Mercury;Atomic Absorption Spectrophotometer.

汞是最危险的化学物质之一，经常被添加到美白霜中。有许多美白霜的制造商或销售商在他们的产品中使用汞，尽管它的使用是被禁止的。本研究对传统市场上的5种美白面霜样品进行了汞的定性和定量分析。用KI试剂进行定性分析，发现5个样品含汞。然后，用原子吸收分光光度计在波长243,7 nm处测定样品中的汞。由验证结果可知，标定曲线得到的回归方程为Y = 0,016779x - 0,04377, LOD和LOQ分别为2,1552µg/L和7,184µg/L。准确度试验表明，回收率在88-97%范围内，精密度试验表明，% RSD值为0.044 -1,57%。五个样本的定量分析结果显示，所有样本的汞含量均在51,576 ppm至3886,776 ppm之间。关键词:美白乳霜;汞;原子吸收分光光度计

引用次数: 5

EVALUASI SEDIAAN EMULGEL ANTI JERAWAT TEA TREE (Melaleuca alternifolia) OIL DENGAN MENGGUNAKAN HPMC SEBAGAI GELLING AGENT

Journal of Pharmacopolium

Pub Date : 2018-09-03 DOI: 10.36465/jop.v1i1.392

Lusi Nurdianti

Tea tree (Melaleuca alternifolia) oil memiliki terpinen-4-ol yang berfungsi sebagai antibakteri dan anti jamur yang memiliki potensi efektivitas mengobati jerawat. Penelitian ini bertujuan untuk mengetahui formulasi pembuatan sediaan dan evaluasi sediaan emugel Tea tree (Melaleuca alternifolia) oil dengan menggunakan Hidroxy propyl methyl cellulose (HPMC) sebagai gelling agent.Untuk memperoleh sediaan emulgel yang memiliki stabilitas baik maka dilakukan serangkaian tahapan penelitian mulai dari pengumpulan bahan baku, formulasi dan evaluasi sediaan emulgel Tea tre oil. Formulasi yang dibuat terdiri dari tiga formula yaitu F1, F2 dan F3 dengan variasi HPMC sebagai gelling agent. Evaluasi yang dilakukan adalah uji organoleptik, pH, homogenitas, daya sebar, viskositas, Cycling test dan uji hedonik. Analisis data hasil uji viskositas dan uji hedonik diolah dengan penjabaran deskriptif. Hasil uji hedonik menunjukan bahwa emulgel anti jerawat tea tree oil dapat diterima oleh responden.

Kata kunci : emulgel, Melaleuca alternifolia, HPMC

油油有4醇的抗菌和抗真菌功能，对痤疮有疗效。这项研究的目的是确定剂型Tea tree的配方，并对使用羟基乙基甲基细胞细胞进行评价。为了获得稳定的意愿包，将进行一系列研究阶段，从原料收集、配方和评估问题膝关节液。它是由F1, F2和F3的三种配方组成进行的评估包括有机测试、pH值、同质性、舒张性、粘度、气旋测试和享乐主义测试。粘度和享乐主义测试的数据分析与描述性概述。酒精测试结果显示，受访者可接受抗痤疮乳胶茶树油。关键词:emulgel, belternifolia, HPMC

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引用次数: 10

UJI ANTIBAKTERI RIMPANG GANDASULI (HEDYCHIUM CORONARIUM) TERHADAP BAKTERI STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI DENGAN PERBANDINGAN METODE EKSTRAKSI 医用菌根根杆菌(HEDYCHIUM CORONARIUM)与菌根菌菌和ESCHERICHIA大肠杆菌进行比较

Journal of Pharmacopolium

Pub Date : 2018-08-20 DOI: 10.36465/jop.v1i2.326

Aris Suhardiman

Indonesia has various types of plants those have potential as medicine to overcome health problems in line with the expanding of traditional medicine industry. One example of plants from the Zingiberaceae family is Hedychium coronarium, which is not widely known by the community despite it has efficacy as an antibacterial which is not inferior to other Zingiberaceae family. The research was conducted to determine whether the Hedychium coronarium rhizome shown to have antibacterial activity against the growth of Staphylococcus aureus and Escherichia coli, knowing antibacterial compound that contained in Hedychium coronarium rhizome, also knowing the most effective extraction method to take the antibacterial compound from Hedychium coronarium rhizome. The gandasuli rhizome was extracted by maceration and reflux with 96% ethanol. Antibacterial activity test carried out by the agar diffusion method, and the analysis of antibacterial compounds with bioautography, and the results are monitored with vanillin-sulfuric acid. Maceration and reflux extract at a concentration of 90% has antibacterial activity with inhibition zones, each for 8 and 10 mm against Escherichia coli as well as 9 and 10 mm against Staphylococcus aureus. Bioautography results show a positive effect on the appearance of vanillin-sulfuric acid. Reflux extract has better antibacterial activity, while the antibacterial compound is an essential oil group. Keywords: Hedychium coronarium, antibacterial, Staphylococcus aureus, Escherichia coli, bioautography.

随着传统医药工业的扩大，印度尼西亚有各种类型的植物，这些植物有潜力作为药物来克服健康问题。姜科植物的一个例子是姜科植物，尽管它具有不低于其他姜科植物的抗菌功效，但它并没有被广泛了解。本研究旨在确定姜花根是否对金黄色葡萄球菌和大肠杆菌的生长具有抑菌活性，了解姜花根中所含的抑菌化合物，以及从姜花根中提取抑菌化合物的最有效方法。采用浸渍法，96%乙醇回流提取干石竹根茎。采用琼脂扩散法进行抑菌活性测试，采用生物自显像法对抑菌化合物进行分析，并采用香兰素-硫酸对结果进行监测。浸渍和回流提取物浓度为90%时具有抑菌活性，对大肠杆菌的抑菌作用分别为8和10 mm，对金黄色葡萄球菌的抑菌作用分别为9和10 mm。生物自显影结果显示对香兰素-硫酸的外观有积极影响。回流提取物具有较好的抑菌活性，抑菌化合物属精油类。关键词:姜花，抗菌，金黄色葡萄球菌，大肠杆菌，生物自传

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引用次数: 0

CHARACTERIZATION AND SYNTHESIZE OF Fe(III) 4-FLUORO-N’-[(PYRIDINE-4-YL)CARBONYL]BENZOHYDRAZIDE COMPLEX AS ANTITUBERCULOSIS CANDIDATE 抗结核候选物铁(III) 4-氟- n′-[(吡啶-4-基)羰基]苯并肼配合物的表征与合成

Journal of Pharmacopolium

Pub Date : 2018-08-20 DOI: 10.36465/JOP.V1I2.332

R. Ruswanto

Synthesis of Fe (III) complex compounds with 4-fluoro-N '- [(pyridine-4-yl) carbonyl] benzohydrazide ligand aims to find out the synthesis method, the complex and characteristic compound formulas of the complexes formed. Instruments used are UV-Visible Spectrophotometry, Infrared Spectrophotometry and Atomic Absorption Spectrophotometry. The synthesis of Fe (III) 4-fluoro-N '- [(pyridine-4-yl) carbonyl] benzohydrazide complexes can be synthesized by mixing metals and ligands dissolved in ethanol by heating at a temperature of 78oC. Compounds of synthesis can form complexes with the formula Fe(C₁₃H₁₀FN₃O₂)Cl₃.2H₂O. Characteristics of the Fe (III) 4-fluoro-N '- [(pyridine-4-yl) carbonyl] benzohydrazide complex compound have a maximum wavelength of 265.6 nm. The absorption of functional groups on the 540.0 cm-1 infra red wave spectrum.

Keywords: synthesis, complex, Fe (III), benzohydrazide

Fe (III)与4-氟- n′-[(吡啶-4-酰基)羰基]苯并肼配体的配合物的合成旨在找出其合成方法、配合物及所形成配合物的特征化合物配方。使用的仪器有紫外可见分光光度法、红外分光光度法和原子吸收分光光度法。Fe (III) 4-氟- n′-[(吡啶-4-酰基)羰基]苯并肼配合物的合成可以在78℃的温度下将溶解在乙醇中的金属与配体混合合成。合成的化合物可形成式为Fe(C13H10FN3O2)Cl3.2H2O的配合物。Fe (III) 4-氟- n′-[(吡啶-4-酰基)羰基]苯并肼配合物的最大波长为265.6 nm。540.0 cm-1红外光谱上官能团的吸收。关键词:合成，配合物，铁(III)，苯并肼

引用次数: 2

GAMBARAN PELAYANAN FARMASI KLINIK DI APOTEK WILAYAH KOTA TANGERANG SELATAN CLINICAL PHARMACY SERVICE AT COMMUNITY PHARMACY IN SOUTH TANGERANG REGENCY

Journal of Pharmacopolium

Pub Date : 2018-08-20 DOI: 10.36465/JOP.V1I2.329

Ahmad Apriansyah

Background : Giving the drug information and counceling are parts of pharmacist clinical task as be stated in ministry of health statue number 35 year 2014 on Pharmacy service standar in community pharmacy (Permenkes no 35 tahun 2017 tentang standar pelayanan kefarmasian di apotek). Through these tasks, pharmacist can inprove the patient therapy outcome. Aim : The purpose o this study was to describe the clinical service of drug information in community pharmacies (CP) at South Tangerang City. Methods : This was a descriptive-explorative study with survey technic. Sample were the 50 CPs and clinical pharmacy services were evaluated on their pharmacist who could be met at the visiting time. Results & Conclusion : Thirty eight percent of pharmacists could be met at the visiting time. The highest percentage of drug information service is drug usage (72,22%) whereas the lowest are drug interaction and the way of its prevention i.e 5,55%. The quality of pharmacy clinical service of drug information is 41,66% and meet the bad criteria. The clinical pharmacy service of drug information in south Tangerang has not been run well and met the Pharmacy service standard yet.

Keywords: drug information service, pharmacit, south tangerang, community pharmacy.

背景:2014年卫生部《社区药房药学服务标准》第35号条例(Permenkes no 35 tahun 2017 tentang standard pelayanan kefarmasian di apotek)规定，提供药品信息和咨询是药师临床工作的一部分。通过这些工作，药师可以提高患者的治疗效果。目的:了解坦格朗市南区社区药房药物信息服务的临床情况。方法:采用调查法进行描述性探索性研究。样本为50名CPs，并对他们的药剂师进行临床药学服务评估，该药剂师在访问时可以满足。结果与结论:38%的药师在访视时能够得到满足。药物信息服务比例最高的是药物使用情况(72.22%)，最低的是药物相互作用及其预防方式(5.55%)。药品信息的药学临床服务质量为41.66%，符合不良标准。坦格南地区药品信息临床药学服务运行不佳，未达到药学服务标准。关键词:药品信息服务，药学，南橘子，社区药房。

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引用次数: 1

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