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Reproductive history and cognitive health among older Norwegian females and males: the population-based HUNT Study 挪威老年女性和男性的生殖史和认知健康：基于人群的HUNT研究
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-01-03 DOI: 10.1016/j.jpsychires.2026.01.001
K. Wolfova , B.H. Strand , J. Weiss , P. Brennan Kearns , T. Mekonnen , Y. Stern , H.-P. Kohler , V.F. Skirbekk , S.E. Tom

Objectives

We explored the relationship between the number of children and cognitive outcomes in later life in a large cohort of older females and males from Norway.

Design

Cross-sectional analysis using multinomial logistic regression.

Settings

The Norwegian HUNT4 70+ Study.

Participants

Males and females aged ≥70 years.

Measurments

The exposure was the number of biological children (none, one, two, three, or four or more). The primary outcome was categorized as dementia, mild cognitive impairment (MCI), or no cognitive impairment.

Results

Among 9263 participants (mean age 78 years; 54 % females), those without children had higher risk of dementia (relative risk ratio [RRR] 1.82, 95 % confidence interval [CI] 1.37 to 2.42) and MCI (RRR 1.31, 95 % CI 1.08 to 1.59) compared to those who had two children, adjusting for age and sex. Similar pattern was observed for those with one child, whereas those with three children did not have an increased MCI or dementia risk. Having four or more children was marginally associated with higher dementia risk (RRR 1.22, 95 % CI 1.00–1.49), but not with MCI risk. This association was attenuated after adjusting for education and marital status, whereas those without children and with one child had still higher risk. In sex-stratified analysis, having no children was associated with higher risk of dementia only in males.

Conclusions

The weak association with high parity, along with the increased dementia risk observed in males without children, contrasts with previous findings. Our results highlight the need for further investigation into the social mechanisms linking reproductive history to cognitive health.
目的：我们对来自挪威的一大群老年男女进行研究，探讨子女数量与晚年认知结局之间的关系。设计采用多项逻辑回归进行横断面分析。挪威HUNT4 70+研究。参与者：年龄≥70岁的男女。暴露量是指亲生子女的数量（没有、一个、两个、三个、四个或更多）。主要结局分为痴呆、轻度认知障碍（MCI）或无认知障碍。结果在9263名参与者中（平均年龄78岁，女性占54%），与有两个孩子的参与者相比，没有孩子的参与者患痴呆（相对风险比[RRR] 1.82, 95%可信区间[CI] 1.37至2.42）和MCI （RRR 1.31, 95% CI 1.08至1.59）的风险更高，调整了年龄和性别。有一个孩子的人也观察到了类似的模式，而有三个孩子的人则没有增加轻度认知障碍或痴呆的风险。有4个或4个以上孩子与较高的痴呆风险有轻微关联（RRR 1.22, 95% CI 1.00-1.49），但与轻度认知障碍风险无关。在调整了教育程度和婚姻状况后，这种关联减弱了，而没有孩子和只有一个孩子的人的风险仍然更高。在性别分层分析中，没有孩子的男性患痴呆症的风险更高。结论：在没有孩子的男性中观察到的高胎次与痴呆风险增加的弱关联，与先前的研究结果形成了对比。我们的研究结果强调需要进一步研究生殖史与认知健康之间的社会机制。
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引用次数: 0
Social determinants of health associated with receipt of psychotherapy for veterans with posttraumatic stress disorder 与创伤后应激障碍退伍军人接受心理治疗相关的健康社会决定因素
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2026-01-03 DOI: 10.1016/j.jpsychires.2026.01.003
Rachel M. Ranney , Beth E. Cohen , Hui Shen , Katherine J. Hoggatt , Shira Maguen
This study aimed to investigate associations between social determinants of health (SDoH, the conditions in which people live) and receipt of psychotherapy among Veterans with posttraumatic stress disorder (PTSD) engaged in care at the Veterans Health Administration. Past research has identified disparities in receipt of PTSD care related to demographics, but there is a lack of research on disparities related to SDoH. This study investigated three SDoH: homelessness, socioeconomic disadvantage, and rurality. Using VHA electronic health records, we included Veterans with a PTSD diagnosis from 2015 to 2018, a total of 435,381 Veterans, and reviewed receipt of PTSD psychotherapy through 2019. In regression models accounting for demographics, trauma exposure, and mental and physical health factors, we found that Veterans who had experienced lifetime homelessness were more likely to receive any PTSD psychotherapy and a minimally adequate dose of PTSD psychotherapy (eight sessions within a 24-week period). We found that Veterans with greater socioeconomic disadvantage and Veterans who resided in rural areas were less likely to receive a minimally adequate dose of PTSD psychotherapy. These findings suggest that efforts are needed to promote engagement with mental healthcare for rural Veterans and those with greater socioeconomic disadvantage.
本研究旨在探讨在退伍军人健康管理局从事护理的创伤后应激障碍（PTSD）退伍军人中健康的社会决定因素（SDoH，人们的生活条件）与接受心理治疗之间的关系。过去的研究已经确定了与人口统计学相关的PTSD治疗的差异，但缺乏与SDoH相关的差异的研究。本研究调查了三个SDoH：无家可归、社会经济劣势和乡村性。使用VHA电子健康记录，我们纳入了2015年至2018年诊断为创伤后应激障碍的退伍军人，共有435381名退伍军人，并回顾了到2019年接受创伤后应激障碍心理治疗的情况。在考虑人口统计学、创伤暴露、精神和身体健康因素的回归模型中，我们发现，经历过终身无家可归的退伍军人更有可能接受创伤后应激障碍心理治疗和最低剂量的创伤后应激障碍心理治疗（24周内8次）。我们发现，社会经济劣势较大的退伍军人和居住在农村地区的退伍军人接受最低剂量的创伤后应激障碍心理治疗的可能性较小。这些发现表明，需要努力促进农村退伍军人和社会经济劣势较大的人参与精神保健。
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引用次数: 0
The relationship between Antibody levels against myelin basic protein in depressive disorder, neuroimaging, and functioning 抗髓鞘碱性蛋白抗体水平在抑郁症、神经影像学和功能之间的关系。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-24 DOI: 10.1016/j.jpsychires.2025.12.048
Samet Öksüz , Aykut Karahan , Hüseyin Yaman , Selçuk Akkaya

Background

Major depressive disorder (MDD) affects approximately 280 million people worldwide, yet its neurobiological mechanisms remain largely unclear. Anti-myelin basic protein (anti-MBP) antibodies, markers of autoimmune activity, have been associated with various neuropsychiatric conditions, but their role in depression is poorly understood. This study examined the associations between serum anti-MBP levels, depression severity, functioning, and hippocampal volume, and compared anti-MBP levels between patients with MDD and healthy controls.

Methods

Thirty patients diagnosed with MDD who applied to the psychiatry outpatient clinic of Farabi Hospital and 30 healthy controls matched for age, gender and education were included. All participants were assessed using the Hamilton Depression Rating Scale (HAM-D), the Montgomery-Åsberg Depression Rating Scale (MADRS), and the Functioning Assessment Short Test (FAST). Venous blood samples were collected to determine anti-MBP levels. Hippocampal volumes were assessed using T1-weighted magnetic resonance imaging.

Results

Linear regression analysis in the total sample of participants demonstrated that anti-MBP levels were significantly associated with a decrease in total (p = 0.020), right (p = 0.013), and left (p = 0.046) hippocampal volume. Furthermore, ROC analysis revealed that anti-MBP levels could distinguish MDD patients from healthy controls with high diagnostic accuracy.

Conclusions

These results suggest a potential association between anti-MBP antibodies and neuroimmune alterations in depression. Across all participants, age- and sex-adjusted regression analyses showed an inverse association between anti-MBP and hippocampal volume. Notably, anti-MBP levels were higher in patients, suggesting its potential utility as a biomarker candidate for future studies in MDD. Consistently, ROC analysis performed well in discriminating between patients and controls.
背景：全球约有2.8亿人患有重度抑郁症（MDD），但其神经生物学机制仍不清楚。抗髓鞘碱性蛋白（anti-MBP）抗体是自身免疫活动的标志物，与各种神经精神疾病有关，但其在抑郁症中的作用尚不清楚。本研究检查了血清抗mbp水平、抑郁严重程度、功能和海马体积之间的关系，并比较了MDD患者和健康对照者的抗mbp水平。方法：选取法拉比医院精神科门诊诊断为重度抑郁症的患者30例和年龄、性别、文化程度相匹配的健康对照者30例。所有参与者均采用汉密尔顿抑郁评定量表（HAM-D）、蒙哥马利-Åsberg抑郁评定量表（MADRS）和功能评估短测试（FAST）进行评估。采集静脉血检测抗mbp水平。采用t1加权磁共振成像评估海马体积。结果：对所有参与者的线性回归分析表明，抗mbp水平与海马总体积（p = 0.020）、右侧体积（p = 0.013）和左侧体积（p = 0.046）的减少显著相关。此外，ROC分析显示，抗mbp水平可以区分MDD患者和健康对照，诊断准确率很高。结论：这些结果提示抗mbp抗体与抑郁症的神经免疫改变之间存在潜在的关联。在所有参与者中，年龄和性别调整的回归分析显示抗mbp与海马体积呈负相关。值得注意的是，患者的抗mbp水平较高，表明其作为未来MDD研究的生物标志物候选物的潜在效用。与此一致，ROC分析在区分患者和对照组方面表现良好。
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引用次数: 0
Dan J. Stein (1962–2025): A life dedicated to the science and care of the mind 丹·斯坦（1962-2025）：一生致力于科学和精神护理。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-24 DOI: 10.1016/j.jpsychires.2025.12.035
Eric Hollander, Naomi Fineberg
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引用次数: 0
Clinicians’ perspectives on family-based therapy (FBT) and psychiatric medication for eating disorders 临床医生对家庭治疗（FBT）和精神药物治疗饮食失调的看法。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-23 DOI: 10.1016/j.jpsychires.2025.12.047
Brad A. MacNeil, Bailey Coon, Talia Gruber, Shainee Price, Magdalena Samela, Reece Sandercock, Emily Wilson
This study examined clinicians’ perspectives of family-based therapy (FBT) and psychiatric medication, and whether they would recommend these for treating their own child or another family member if they had an eating disorder (ED). Participants were 80 clinicians (45 women, 35 men; Mage = 31.7 years) who completed an e-survey that included questions about their profession, whether they use FBT, training, and length of time providing it. Participants also reported their main theoretical orientation, whether they recommend FBT to their patients, and if they would recommend it to their own child or another family member. Approximately 42.5 % were physicians or psychiatrists, 30.1 % nurses or nurse practitioners, and 27.6 % therapists (e.g., psychologist, social worker etc.). The average amount of time they had been providing treatment for EDs was 4.38 years (SD = 1.09). Treatment settings included hospitals (45 %), community mental health (31.3 %), private practice (15 %), and residential treatment (8.8 %). Most participants were FBT trained (98.8 %) by in person workshop with supervision (46.8 %), in person workshop only (31.6 %), or other (21.6 %; online training, self-paced reading). Engagement in consultation or supervision for FBT was reported by 83.8 % of clinicians. All providers endorsed recommending FBT to their patients or another family member if they had an ED, whereas 88.8 % would recommend it for their own child. A considerable proportion of clinicians (96.3 %) would agree to start their own family member on psychiatric medication if they had an ED. These results have important implications for training and dissemination of the FBT.
这项研究调查了临床医生对家庭治疗（FBT）和精神药物的看法，以及他们是否会推荐这些治疗自己的孩子或其他患有饮食失调症（ED）的家庭成员。参与者是80名临床医生（45名女性，35名男性；年龄= 31.7岁），他们完成了一项电子调查，包括他们的职业、是否使用FBT、培训和提供FBT的时间长短。参与者还报告了他们的主要理论取向，他们是否会向他们的病人推荐FBT，以及他们是否会向自己的孩子或其他家庭成员推荐FBT。大约42.5%是医生或精神科医生，30.1%是护士或执业护士，27.6%是治疗师（如心理学家、社会工作者等）。他们为ed提供治疗的平均时间为4.38年（SD = 1.09）。治疗环境包括医院（45%）、社区精神卫生（31.3%）、私人诊所（15%）和住院治疗（8.8%）。大多数参与者接受了FBT培训（98.8%），包括有监督的现场研讨会（46.8%）、仅现场研讨会（31.6%）或其他（21.6%；在线培训，自定进度阅读）。83.8%的临床医生参与了FBT的咨询或监督。如果患者或其他家庭成员患有ED，所有的医疗服务提供者都赞成向他们推荐FBT，而88.8%的医疗服务提供者会向他们自己的孩子推荐FBT。相当比例的临床医生（96.3%）同意如果他们的家庭成员有ED，他们会开始使用精神药物。这些结果对FBT的培训和传播具有重要意义。
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引用次数: 0
Intolerance of uncertainty as a factor in hoarding treatment 对不确定性的不容忍是囤积治疗的一个因素。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-23 DOI: 10.1016/j.jpsychires.2025.12.044
Michael G. Wheaton , Rachel Van Boxtel , Carolyn I. Rodriguez

Purpose

Hoarding disorder (HD) involves difficulty discarding clutter. Existing treatments for HD (including cognitive-behavioral therapy [CBT]) yield only partial symptom reduction. Identifying factors that contribute to hoarding may inform potential treatment mechanisms. One such factor is intolerance of uncertainty (IU), the tendency to maladaptively respond to the unknown via fear, discomfort, and avoidance. While IU has been linked to hoarding symptoms, its role in treatment outcomes remains understudied.

Methods

41 adults with HD completed the Buried in Treasures (BIT+) Workshop (a 16-session manualized skills group using CBT principles, with 10 additional supervised in-home uncluttering practice). IU and HD symptom severity were assessed pre- and post-treatment.

Results

Pre-treatment IU did not significantly predict improvement in hoarding symptoms (β = .15, p = .31). However, IU significantly decreased following treatment (t = 2.23, p = .017). Smaller reductions in IU significantly predicted worse hoarding symptom outcomes, accounting for baseline severity (β = .41, p < .01).

Conclusions

Results suggest that high initial levels of IU may not prevent patients from benefiting from hoarding treatment via the BIT+, but that reduction in IU accounts for a significant increment in hoarding treatment gains. Given the room for improvement evident in HD treatments, future research might consider augmenting existing treatment with IU-specific interventions to boost treatment efficacy.
目的：囤积障碍（HD）涉及难以丢弃杂物。现有的HD治疗方法（包括认知行为疗法[CBT]）只能部分减轻症状。确定导致囤积的因素可能为潜在的治疗机制提供信息。其中一个因素是对不确定性的不耐受（IU），即通过恐惧、不适和回避对未知做出不适应反应的倾向。虽然IU与囤积症状有关，但其在治疗结果中的作用仍未得到充分研究。方法：41名成人HD患者完成了埋藏在宝藏（BIT+）工作坊（一个使用CBT原则的16次手工技能小组，另外有10次在家监督整理练习）。治疗前后分别评估IU和HD症状严重程度。结果：治疗前IU不能显著预测囤积症状的改善（β = 0.15, p = 0.31）。然而，治疗后IU显著降低（t = 2.23, p = 0.017）。较小的IU减少显著预测更糟糕的囤积症状结果，考虑到基线严重程度（β = 0.41, p）。结论：结果表明，高初始IU水平可能不会阻止患者从BIT+治疗中获益，但IU的减少可以显著增加囤积治疗的收益。鉴于HD治疗有明显的改进空间，未来的研究可能会考虑用iu特异性干预措施来增加现有治疗，以提高治疗效果。
{"title":"Intolerance of uncertainty as a factor in hoarding treatment","authors":"Michael G. Wheaton ,&nbsp;Rachel Van Boxtel ,&nbsp;Carolyn I. Rodriguez","doi":"10.1016/j.jpsychires.2025.12.044","DOIUrl":"10.1016/j.jpsychires.2025.12.044","url":null,"abstract":"<div><h3>Purpose</h3><div>Hoarding disorder (HD) involves difficulty discarding clutter. Existing treatments for HD (including cognitive-behavioral therapy [CBT]) yield only partial symptom reduction. Identifying factors that contribute to hoarding may inform potential treatment mechanisms. One such factor is intolerance of uncertainty (IU), the tendency to maladaptively respond to the unknown via fear, discomfort, and avoidance. While IU has been linked to hoarding symptoms, its role in treatment outcomes remains understudied.</div></div><div><h3>Methods</h3><div>41 adults with HD completed the Buried in Treasures (BIT+) Workshop (a 16-session manualized skills group using CBT principles, with 10 additional supervised in-home uncluttering practice). IU and HD symptom severity were assessed pre- and post-treatment.</div></div><div><h3>Results</h3><div>Pre-treatment IU did not significantly predict improvement in hoarding symptoms (β = .15, p = .31). However, IU significantly decreased following treatment (t = 2.23, p = .017). Smaller reductions in IU significantly predicted worse hoarding symptom outcomes, accounting for baseline severity (β = .41, <em>p</em> &lt; .01).</div></div><div><h3>Conclusions</h3><div>Results suggest that high initial levels of IU may not prevent patients from benefiting from hoarding treatment via the BIT+, but that reduction in IU accounts for a significant increment in hoarding treatment gains. Given the room for improvement evident in HD treatments, future research might consider augmenting existing treatment with IU-specific interventions to boost treatment efficacy.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"194 ","pages":"Pages 116-122"},"PeriodicalIF":3.2,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145863317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of premenstrual dysphoric disorder treatment with antidepressants and combined oral contraceptives: a systematic review with network meta-analysis 抗抑郁药与联合口服避孕药治疗经前焦虑症的比较：一项网络荟萃分析的系统综述。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-23 DOI: 10.1016/j.jpsychires.2025.12.046
Luigi Chermont Berni, Leticia Ribeiro Nunes, Rita de Cássia Silva de Oliveira

Objective

Evaluate the treatment of Premenstrual Dysphoric Disorder (PMDD) with antidepressants and combined oral contraceptives (COCs) in order to identify the most appropriate treatments available, with the best tolerability and acceptability.

Results

Sixteen studies were included in the systematic review, of which five were incorporated into the network meta-analysis. Continuous paroxetine showed the greatest effect across all evaluated symptom domains. The 24/4 DROS/EE regimen was the most effective COC, showing particularly positive outcomes for both physical and emotional symptoms.

Conclusions

The network meta-analysis indicates that both SSRIs and COCs are effective in managing PMDD, with continuous paroxetine and DROS/EE 24/4 emerging as the most effective strategies in their respective categories. Treatment choice should consider predominant symptom patterns, individual tolerability, and reproductive planning. Further direct comparative clinical trials between these therapeutic classes are needed to guide clinical decision-making with greater precision.
目的：评价抗抑郁药联合口服避孕药（COCs）治疗经前烦躁不安（PMDD）的疗效，以确定最佳耐受性和可接受性的治疗方案。结果：系统评价纳入16项研究，其中5项纳入网络meta分析。持续使用帕罗西汀在所有评估的症状领域显示出最大的效果。24/4 DROS/EE方案是最有效的COC，对身体和情绪症状都显示出特别积极的结果。结论：网络荟萃分析表明，SSRIs和COCs在治疗PMDD方面都是有效的，其中持续使用帕罗西汀和DROS/EE 24/4是各自类别中最有效的策略。治疗选择应考虑主要症状模式、个体耐受性和生育计划。需要在这些治疗类别之间进行进一步的直接比较临床试验，以更精确地指导临床决策。
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引用次数: 0
Latent profiles of affective temperaments can support differentiation of bipolar I disorder, bipolar II disorder, and major depressive disorder 情感气质的潜在特征可以支持双相I型、双相II型和重度抑郁症的区分。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-22 DOI: 10.1016/j.jpsychires.2025.12.045
Myeongkeun Cho , Heejae Lee , C. Hyung Keun Park

Background

Differentiating bipolar I, bipolar II, and major depressive disorders is essential; therefore, the relationship between affective temperaments and mood disorder diagnoses has garnered considerable attention.

Objectives

This study aimed to explore the representative types of Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) profiles and examine their associations with the proportions of bipolar I, bipolar II, and major depressive disorders.

Methods

Psychiatric outpatients diagnosed with bipolar I, bipolar II, or major depressive disorder and aged ≥18 years were analyzed. Latent profile analysis was conducted using TEMPS-A scores, and each patient was classified into a subgroup according to their TEMPS-A scores. After that, multinomial logistic regression was conducted to verify the relationship between TEMPS-A profiles and mood disorder diagnoses.

Results

The results indicated that the seven-profile model was the most appropriate. Furthermore, the cyclothymic profile and anxious, cyclothymic and depressive profile increased the likelihood of bipolar II disorder, while the cyclothymic and hyperthymic profile; cyclothymic, depressive and irritable profile; and anxious, cyclothymic, hyperthymic and irritable profile increased the likelihood of bipolar II and bipolar I disorders.

Conclusion

Cyclothymic temperament can be a risk factor for bipolarity. Moreover, hyperthymic or irritable temperaments might help differentiate between bipolar I and bipolar II disorders.
背景：区分I型双相情感障碍、II型双相情感障碍和重度抑郁症是必要的；因此，情感气质和情绪障碍诊断之间的关系已经引起了相当大的关注。目的：本研究旨在探讨孟菲斯、比萨、巴黎和圣地亚哥的气质评估（tempa）的代表性类型，并研究其与双相I型、双相II型和重度抑郁症比例的关系。方法：对年龄≥18岁、诊断为双相I型、双相II型或重度抑郁症的精神科门诊患者进行分析。使用TEMPS-A评分进行潜在特征分析，并根据tems - a评分将患者分为亚组。之后，采用多项logistic回归验证TEMPS-A谱与情绪障碍诊断的关系。结果：结果表明，七轮廓模型是最合适的。此外，循环胸腺特征和焦虑、循环胸腺特征和抑郁特征增加了双相情感障碍II型的可能性，而循环胸腺特征和亢进胸腺特征；周期性、抑郁和易怒；焦虑，循环胸腺，亢奋和易怒的特征增加了双相情感障碍II和I的可能性。结论：循环胸腺气质可能是双极性的危险因素。此外，胸腺亢进或易怒可能有助于区分双相情感障碍I型和双相情感障碍II型。
{"title":"Latent profiles of affective temperaments can support differentiation of bipolar I disorder, bipolar II disorder, and major depressive disorder","authors":"Myeongkeun Cho ,&nbsp;Heejae Lee ,&nbsp;C. Hyung Keun Park","doi":"10.1016/j.jpsychires.2025.12.045","DOIUrl":"10.1016/j.jpsychires.2025.12.045","url":null,"abstract":"<div><h3>Background</h3><div>Differentiating bipolar I, bipolar II, and major depressive disorders is essential; therefore, the relationship between affective temperaments and mood disorder diagnoses has garnered considerable attention.</div></div><div><h3>Objectives</h3><div>This study aimed to explore the representative types of Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Autoquestionnaire (TEMPS-A) profiles and examine their associations with the proportions of bipolar I, bipolar II, and major depressive disorders.</div></div><div><h3>Methods</h3><div>Psychiatric outpatients diagnosed with bipolar I, bipolar II, or major depressive disorder and aged ≥18 years were analyzed. Latent profile analysis was conducted using TEMPS-A scores, and each patient was classified into a subgroup according to their TEMPS-A scores. After that, multinomial logistic regression was conducted to verify the relationship between TEMPS-A profiles and mood disorder diagnoses.</div></div><div><h3>Results</h3><div>The results indicated that the seven-profile model was the most appropriate. Furthermore, the <em>cyclothymic profile</em> and <em>anxious, cyclothymic and depressive profile</em> increased the likelihood of bipolar II disorder, while the <em>cyclothymic and hyperthymic profile</em>; <em>cyclothymic, depressive and irritable profile</em>; and <em>anxious, cyclothymic, hyperthymic and irritable profile</em> increased the likelihood of bipolar II and bipolar I disorders.</div></div><div><h3>Conclusion</h3><div>Cyclothymic temperament can be a risk factor for bipolarity. Moreover, hyperthymic or irritable temperaments might help differentiate between bipolar I and bipolar II disorders.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"194 ","pages":"Pages 79-84"},"PeriodicalIF":3.2,"publicationDate":"2025-12-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145834244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective serotonin re-uptake inhibitor use and risk of gastrointestinal bleeding in aspirin users 选择性血清素再摄取抑制剂的使用和阿司匹林使用者胃肠道出血的风险。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-21 DOI: 10.1016/j.jpsychires.2025.12.038
Yihui He , Xin Zhang , Qixuan Luo , Yitian Chen , Ziting Gao , Hongye Wei , Yajing Wei , Ziyi Qiu , Wuqing Huang

Background and objective

Both aspirin and selective serotonin reuptake inhibitors (SSRIs) have been linked to an increased risk of gastrointestinal (GI) bleeding, while the interaction between the combined use of these two drugs on GI bleeding remains unclear. We aimed to explore the association between SSRIs use and risk of GI bleeding among aspirin users.

Methods

This is a prospective cohort study of 12,712 new aspirin users with a history of ischemic cardiovascular disease from the UK Biobank. Information on aspirin or SSRIs prescriptions was retrieved from primary care records, and GI bleeding data from hospital inpatient admissions. A competing risk model was used to calculate hazard ratios (HRs) and 95 % confidence intervals (CIs).

Results

The incidence rate was 7.44 and 4.99 per 1000 person-years in the group of SSRIs and non-SSRIs use, respectively. A significant positive association was observed between SSRIs use and GI bleeding risk among aspirin users (Adjusted HR,1.27; 95 % CI, 1.01–1.58). The observed association was more pronounced in younger adults, females, individuals with a history of GI bleeding or those using PPIs. Besides, the association varied across different types of SSRIs, with paroxetine users showing the highest risk of GI bleeding (Adjusted HR, 1.73; 95 % CI, 1.06–2.83).

Conclusion

This study indicated an additional risk of GI bleeding associated with SSRIs use in aspirin users, especially when combining paroxetine with aspirin. This finding underscores the necessity for further investigation into the differential risks of specific SSRIs to guide personalized polypharmacy.
背景和目的：阿司匹林和选择性5 -羟色胺再摄取抑制剂（SSRIs）均与胃肠道出血风险增加有关，而这两种药物联合使用对胃肠道出血的相互作用尚不清楚。我们的目的是探讨阿司匹林使用者使用SSRIs与胃肠道出血风险之间的关系。方法：这是一项前瞻性队列研究，来自英国生物银行的12,712名有缺血性心血管疾病史的新阿司匹林使用者。从初级保健记录和住院患者的胃肠道出血数据中检索阿司匹林或SSRIs处方信息。采用竞争风险模型计算风险比（hr）和95%置信区间（ci）。结果：SSRIs组和非SSRIs组的发病率分别为7.44和4.99 / 1000人年。在阿司匹林使用者中，ssri类药物的使用与胃肠道出血风险之间存在显著的正相关（校正HR，1.27; 95% CI, 1.01-1.58）。观察到的关联在年轻人、女性、有胃肠道出血史的个体或使用PPIs的个体中更为明显。此外，不同类型的SSRIs的相关性也不同，帕罗西汀使用者胃肠道出血的风险最高（调整后风险比1.73;95% CI 1.06-2.83）。结论：本研究表明，阿司匹林使用者使用ssri类药物会增加消化道出血的风险，特别是当帕罗西汀与阿司匹林联合使用时。这一发现强调了进一步研究特定SSRIs的不同风险以指导个性化综合用药的必要性。
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引用次数: 0
Neural mechanisms of response inhibition impairments in patients with perimenopausal insomnia 围绝经期失眠症患者反应抑制障碍的神经机制。
IF 3.2 2区 医学 Q1 PSYCHIATRY
Journal of psychiatric research
Pub Date : 2025-12-18 DOI: 10.1016/j.jpsychires.2025.12.043
Daijie Hu , Kuaile Hu , Tianwei She , Liyong Yu , Yuqi He , Qinhan Yang , Tong Li , Xinyi Wei , Wenting Lin , Lu Yang , Yuxing Wei , Haiyan Zhou , Zhengjie Li , Siyi Yu

Objective

This study aimed to investigate the neural mechanisms underlying impaired response inhibition in patients with perimenopausal insomnia (PMI) using event-related potentials (ERP) and resting-state functional connectivity (rsFC) approaches.

Methods

PMI patients and age-matched healthy controls (HCs) completed clinical assessments, electroencephalography (EEG), and functional magnetic resonance imaging. Response inhibition was evaluated using the stop signal task (SST). EEG data were analyzed for ERP components and event-related spectral perturbations (ERSP), and rsFC analyses were conducted using seed regions in the right inferior frontal cortex (IFC), including the ventral posterior (vpIFC) and anterior (aIFC) subregions. Correlation analyses were conducted among neurophysiological indices and clinical measures.

Results

Compared to HCs, PMI patients exhibited prolonged stop signal reaction time, enhanced Stop-N2 amplitudes, and delayed Stop-P3 responses. ERSP analysis revealed reduced beta-band event-related desynchronization (ERD). RsFC analysis showed decreased connectivity between the vpIFC and inferior temporal gyrus (ITG), and increased connectivity between the aIFC and precuneus and posterior cingulate gyrus in PMI patients. Correlation analysis indicated that ERD power and rsFC alterations were significantly associated with hyperarousal and behavioral activation system traits.

Conclusions

This study confirms impaired response inhibition in PMI patients, primarily manifested through aberrant electrophysiological processes underlying inhibitory control. Altered rsFC between the IFC and both the default mode network and temporal network may represent the neural basis of impaired response inhibition. These findings highlight potential neural markers of inhibitory dysfunction in PMI and suggest that hyperarousal and motivational dysregulation may play a key role in its pathophysiology.
目的：采用事件相关电位（ERP）和静息状态功能连接（rsFC）方法探讨围绝经期失眠（PMI）患者反应抑制受损的神经机制。方法：PMI患者和年龄匹配的健康对照（hc）完成临床评估、脑电图（EEG）和功能磁共振成像（mri）。使用停止信号任务（SST）评估反应抑制。对脑电数据进行ERP成分和事件相关谱扰动（ERSP）分析，并利用右侧下额叶皮层（IFC）的种子区（包括腹侧后（vpIFC）和前（aIFC）亚区）进行rsFC分析。对神经生理指标与临床指标进行相关性分析。结果：与hcc患者相比，PMI患者表现出延长的停止信号反应时间，增强的停止- n2振幅和延迟的停止- p3反应。ERSP分析显示β -波段事件相关不同步（ERD）减少。RsFC分析显示，PMI患者vpIFC与颞下回（ITG）之间的连通性降低，而aIFC与楔前叶和扣带回后回之间的连通性增加。相关分析表明，ERD功率和rsFC改变与高唤醒和行为激活系统特征显著相关。结论：本研究证实PMI患者的反应抑制受损，主要表现为抑制控制下的异常电生理过程。IFC与默认模式网络和时间网络之间rsFC的改变可能代表了反应抑制受损的神经基础。这些发现强调了PMI中抑制功能障碍的潜在神经标志物，并表明过度觉醒和动机失调可能在其病理生理中起关键作用。
{"title":"Neural mechanisms of response inhibition impairments in patients with perimenopausal insomnia","authors":"Daijie Hu ,&nbsp;Kuaile Hu ,&nbsp;Tianwei She ,&nbsp;Liyong Yu ,&nbsp;Yuqi He ,&nbsp;Qinhan Yang ,&nbsp;Tong Li ,&nbsp;Xinyi Wei ,&nbsp;Wenting Lin ,&nbsp;Lu Yang ,&nbsp;Yuxing Wei ,&nbsp;Haiyan Zhou ,&nbsp;Zhengjie Li ,&nbsp;Siyi Yu","doi":"10.1016/j.jpsychires.2025.12.043","DOIUrl":"10.1016/j.jpsychires.2025.12.043","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the neural mechanisms underlying impaired response inhibition in patients with perimenopausal insomnia (PMI) using event-related potentials (ERP) and resting-state functional connectivity (rsFC) approaches.</div></div><div><h3>Methods</h3><div>PMI patients and age-matched healthy controls (HCs) completed clinical assessments, electroencephalography (EEG), and functional magnetic resonance imaging. Response inhibition was evaluated using the stop signal task (SST). EEG data were analyzed for ERP components and event-related spectral perturbations (ERSP), and rsFC analyses were conducted using seed regions in the right inferior frontal cortex (IFC), including the ventral posterior (vpIFC) and anterior (aIFC) subregions. Correlation analyses were conducted among neurophysiological indices and clinical measures.</div></div><div><h3>Results</h3><div>Compared to HCs, PMI patients exhibited prolonged stop signal reaction time, enhanced Stop-N2 amplitudes, and delayed Stop-P3 responses. ERSP analysis revealed reduced beta-band event-related desynchronization (ERD). RsFC analysis showed decreased connectivity between the vpIFC and inferior temporal gyrus (ITG), and increased connectivity between the aIFC and precuneus and posterior cingulate gyrus in PMI patients. Correlation analysis indicated that ERD power and rsFC alterations were significantly associated with hyperarousal and behavioral activation system traits.</div></div><div><h3>Conclusions</h3><div>This study confirms impaired response inhibition in PMI patients, primarily manifested through aberrant electrophysiological processes underlying inhibitory control. Altered rsFC between the IFC and both the default mode network and temporal network may represent the neural basis of impaired response inhibition. These findings highlight potential neural markers of inhibitory dysfunction in PMI and suggest that hyperarousal and motivational dysregulation may play a key role in its pathophysiology.</div></div>","PeriodicalId":16868,"journal":{"name":"Journal of psychiatric research","volume":"194 ","pages":"Pages 58-68"},"PeriodicalIF":3.2,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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