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Diagnostic value of anti-SA antibodies and antibodies to heterogeneous nuclear ribonucleoprotein K in rheumatoid arthritis 抗sa抗体和异质核核糖核蛋白K抗体在类风湿关节炎中的诊断价值
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-6-57-63
M. V. Volkova, A. Kunder, D. Roggenbuck
Annotation The aim of the research is to determine the levels and frequency of antibodies popularity to cyclic citrullinated peptide (APCCP), rheumatoid factor (RF), anti-Sa antibodies and antibodies to heterogeneous nuclear ribonucleoprotein K (anti-gRNP K) in rheumatoid arthritis (RA) and to compare their diagnostic characteristics, and also to determine sensitivity and specificity of anti-Sa antibodies, anti-hRNP K in seronegative RA. Material and methods. The study included 270 patients with RA and 50 healthy individuals. The levels of ACCP, anti-Sa, anti-hRNP K were assessed in blood serum samples from patients by enzyme-linked immunosorbent assay using commercial test systems. RF levels were assessed by kinetic nephelometry on automatic analyzer. Results. The levels and popularity frequency of the studied antibodies in patients with RА were significantly higher than in healthy individuals (p <0.05). Tests based on ADCP detection had the highest indices of sensitivity and specificity for RA diagnosis; sensitivity - 78.01%, specificity - 100.00%, and RF - 70.64%, specificity 96.97%. In case of serogegative APCCP and RA RF, diagnostic sensitivity of anti-Sa antibodies determination was 50.00%, specificity was 96.77%, sensitivity of anti-hRNP K antibodies determination was 55.56%, and specificity was 100.00%. Conclusion. Considering high specificity of tests for anti-Sa and anti-hRNP K antibodies in seronegative RA, they can be considered as additional confirmatory diagnostic tests.
本研究旨在确定类风湿关节炎(RA)中环瓜氨酸肽(APCCP)、类风湿因子(RF)、抗sa抗体和异质核核糖核蛋白K抗体(抗grnp K)流行抗体的水平和频率,比较其诊断特征,并确定血清阴性RA中抗sa抗体、抗hrnp K抗体的敏感性和特异性。材料和方法。该研究包括270名RA患者和50名健康人。采用商用检测系统,采用酶联免疫吸附法检测患者血清中ACCP、抗sa、抗hrnp K水平。在自动分析仪上用动态浊度法测定射频水平。结果。RА患者的抗体水平和流行频率均显著高于健康人群(p <0.05)。基于ADCP检测的试验诊断RA的敏感性和特异性指标最高;灵敏度为78.01%,特异性为100.00%,RF为70.64%,特异性为96.97%。在APCCP和RA RF血清阴性的情况下,抗sa抗体检测的诊断敏感性为50.00%,特异性为96.77%,抗hrnp K抗体检测的敏感性为55.56%,特异性为100.00%。结论。考虑到血清阴性RA的抗sa和抗hrnp K抗体检测的高特异性,可以考虑将其作为额外的确证性诊断检测。
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引用次数: 0
Achievements, threats and risks of medical and pharmaceutical activities in the Republic of Belarus 白俄罗斯共和国医疗和药品活动的成就、威胁和风险
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-3-11-19
V. S. Glushanko, A. Shulmin, V. V. Kugach, É. N. Tarasova, G. A. Khutkina, N. V. Tihonova
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引用次数: 2
Drug safety monitoring in the Republic of Sakha (Yakutia) 萨哈共和国(雅库特)药品安全监测
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-5-77-80
A. A. Everstova, I. I. Bubiakina, A. A. Kuzmina, I. Malogulova, T. M. Klimova
The aim of the research is analysis of frequency and nature of adverse reactions during the use of drugs in the Republic of Sakha (Yakutia) according to automated information system of Russian Federal Service for Surveillance in Healthcare “Pharmacovigilance” (Roszdravnadzor “Pharmakonadzor”). Material and methods. Data from the AIS Roszdravnadzor “Pharmakonadzor” in the Republic of Sakha (Yakutia) for the period from 2014 to 2019 were used for the analysis. It should be noted that since April 1, 2019 data collection is carried out using the modified notification form. Results. For the period of 2014-2019 300 reports (292 primary and 8 repeated) on adverse reactions and cases of therapeutic ineffectiveness of drugs were registered. According to the leading criterion concerning person’s life severity, there were notifications on 20 deaths of patients, 60 life-threatening cases, 1 case of disability, 105 cases of hospitalization or prolongation of its terms, 35 clinically significant event cases. It was noted, that mainly, antimicrobial drugs and drugs for nervous system treatment caused adverse reactions. Conclusion. Report frequency on drugs adverse reactions or lack of therapeutic effect in the region was assessed as insufficient. There should be additional training for medical workers on the procedure for implementing pharmacovigilance in medical organizations, correct notification filling, which ensures reports completeness and its quality
研究的目的是根据俄罗斯联邦医疗保健监督服务局“药物警戒”(Roszdravnadzor“Pharmakonadzor”)的自动信息系统,分析萨哈共和国(雅库特)使用药物期间不良反应的频率和性质。材料和方法。分析使用了萨哈共和国(雅库特)AIS Roszdravnadzor“Pharmakonadzor”2014年至2019年期间的数据。需要注意的是,自2019年4月1日起,使用修改后的通知表进行数据收集。结果。2014-2019年共登记药品不良反应报告300例(主要报告292例,重复报告8例)。根据关于人的生命严重程度的主要标准,通报了20例患者死亡、60例危及生命的病例、1例残疾、105例住院或延长住院期限、35例临床重大事件。注意到,主要是抗菌药物和神经系统治疗药物引起的不良反应。结论。该地区药物不良反应报告频次或缺乏治疗效果被评估为不足。应该对医务工作者进行额外的培训,了解在医疗机构实施药物警戒的程序,正确填写通知,以确保报告的完整性和质量
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引用次数: 0
Influence of Mycoplasma pneumonia on the course of chronic hypertrophic rhinitis 肺炎支原体对慢性肥厚性鼻炎病程的影响
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-4-36-40
O. V. Parilova, A. N. Markina, T. Kapustina, I. Olianina
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引用次数: 0
Jervell and Lange-Nielsen syndrome. Family case (clinical observation) Jervell和Lange-Nielsen综合征。家庭病例(临床观察)
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-5-88-92
T. Tolstikova, L. Bregel, S.V. Czurkan, T. Marchuk, A. V. Dudnik
A clinical family case of Jervell and Lange-Nielsen syndrome in 2 children is presented. Long QT syndrome is one of the leading causes of sudden cardiac death in children. Jervell and Lange-Nielsen syndrome is one of the most severe and rare types of long QT syndrome. Symptoms of the disease appear in infancy; they are characterized by a lengthening of QT interval on ECG, syncope as a result of life-threatening ventricular tachycardia and ventricular fibrillation, combined with congenital bilateral hearing loss.
本文报告2例儿童Jervell - Lange-Nielsen综合征的临床家庭病例。长QT综合征是儿童心源性猝死的主要原因之一。Jervell和Lange-Nielsen综合征是长QT综合征中最严重和罕见的类型之一。该病的症状出现在婴儿期;其特点是心电图QT间期延长,危及生命的室性心动过速和心室颤动导致晕厥,并伴有先天性双侧听力损失。
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引用次数: 1
Managing Customer Success in Business Markets: Conceptual Foundation and Practical Application 在商业市场中管理客户成功:概念基础和实际应用
Pub Date : 2020-01-01 DOI: 10.15358/2511-8676-2020-2-3-121
Andreas Eggert, Wolfgang Ulaga, Anna Gehring
Customer success management is gaining momentum in business markets. From an initial focus on selected industries, such as software-as-a-service, interest in customer success is spreading among business-to-business marketing practitioners. To date, academia has largely neglected this concept and its organizational implementation. Based on extant managerial literature and research on value in use in business markets, we distinguish between customer success as a customer-perceived construct, customer success management as a joint customer-supplier management process, and the emerging job position of customer success managers in supplier organizations. Based on the case of a provider of IoT devices, software and services in decision agriculture, we illustrate how customer success management is practiced in a business marketing context and refine our understanding of customer success management and its constituents. Finally, we suggest promising avenues for future research in this managerially important, under-researched and rapidly growing domain.
客户成功管理在商业市场中获得了动力。从最初关注选定的行业,如软件即服务,对客户成功的兴趣正在企业对企业的营销从业者中传播。迄今为止,学术界在很大程度上忽视了这一概念及其组织实施。基于现有的管理文献和对商业市场中使用价值的研究,我们区分了客户成功作为客户感知的结构,客户成功管理作为客户-供应商联合管理过程,以及客户成功经理在供应商组织中的新兴工作职位。基于决策农业中物联网设备、软件和服务提供商的案例,我们说明了客户成功管理是如何在商业营销环境中实践的,并完善了我们对客户成功管理及其组成部分的理解。最后,我们提出了在这个管理上重要的、研究不足的和快速发展的领域未来研究的有希望的途径。
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引用次数: 11
Диагностика нейропатической боли: шкалы и вопросники 神经病理疼痛诊断:量表和问卷
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-3-61-69
M. Petrova, N. A. Shnayder, E. Pronina, O. P. Bobrova
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引用次数: 6
Analysis of pregnancy outcomes at 25-37 weeks in case of pelvic fracture 骨盆骨折25-37周妊娠结局分析
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-5-93-95
I. S. Stepanova, V. Terekhina
The aim of the work is to study clinical cases and outcomes of pregnancy in women who have pelvic fracture during pregnancy. The article examines two cases of concomitant injury in pregnant patients at 25-37 weeks. In both cases, there is a break of pelvic bones of various localization. On basis of these observations, the authors draw conclusions about the significance of the mother’s condition and associated injuries for a favorable outcome.
这项工作的目的是研究临床病例和妊娠期间发生骨盆骨折的妇女的妊娠结局。本文研究了25-37周妊娠患者的两例伴发损伤。在这两种情况下,都有骨盆骨不同部位的骨折。在这些观察的基础上,作者得出结论,母亲的状况和相关的伤害对一个有利的结果的重要性。
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引用次数: 0
Cardiorenal syndrome in patients with type 2 diabetes and hypertension 2型糖尿病合并高血压患者的心肾综合征
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-1-45-54
N. B. Osetrova, E. Kublik, E. Mineeva
{"title":"Cardiorenal syndrome in patients with type 2 diabetes and hypertension","authors":"N. B. Osetrova, E. Kublik, E. Mineeva","doi":"10.20333/2500136-2020-1-45-54","DOIUrl":"https://doi.org/10.20333/2500136-2020-1-45-54","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"154 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85509392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Opportunities to increase the objectivity while grading practical skills at the exam on Propaedeutics of Internal Diseases 在内科学专业考试中增加客观评分的机会
Pub Date : 2020-01-01 DOI: 10.20333/2500136-2020-1-55-59
N. Shimokhina, E. Kharkov, E. Taptygina, N. A. Balashova
Цель исследования. В 2018 году в ФГБОУ ВО «Красноярском государственном медицинском университете имени профессора В.Ф.ВойноЯсенецкого» Минздрава России (далее – КрасГМУ) впервые практический экзамен по дисциплине «Пропедевтика внутренних болезней» у студентов третьего курса лечебного факультета проведен в два этапа. Целью настоящего исследования стала оценка уровня овладения практическими навыками студентами третьего курса лечебного факультета КрасГМУ по дисциплине «Пропедевтика внутренних болезней», а также возможности повышения объективности их оценивания. Материал и методы. Демонстрация практических навыков оценивалась на первом экзаменационном этапе у 402 студентов, на втором – у 411 человек. Статистический анализ полученных данных осуществляли с использованием пакета прикладных программ Statistica 7.0 (StatSoft Inc., 2004). Результаты. Первый этап практического экзамена проводился на кафедре пропедевтики внутренних болезней и терапии. Второй этап выполнялся впервые на кафедре – центре симуляционных технологий КрасГМУ. Экзаменационные практические навыки включали обязательные разделы: обследование органов дыхания, обследование сердечно-сосудистой системы, обследование пищеварительной системы. Предлагалось продемонстрировать практические навыки по эндокринной, мочевыделительной и другим системам. На втором этапе практического экзамена могли быть предложены для демонстрации еще три дополнительных практических навыка. Средний балл, полученный студентами на первом этапе практического экзамена, составил 4,0 (3,6 – 4,7), на втором этапе, средний балл был достоверно выше и составил 4,7 (4,3 – 5,0). В ходе выполнения второго этапа практического экзамена большинство студентов за демонстрацию трех обязательных практических навыков получили оценки «хорошо» и «отлично». Заключение. На втором этапе практического экзамена для повышения объективности оценки уровня подготовки студентов предложено привлечение независимых преподавателей, использование симуляционных технологий и листов экспертных оценок. Ключевые слова: пропедевтика внутренних болезней, лечебный факультет, практический экзамен, навыки и умения, симуляционный центр, чек-листы. Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи. Для цитирования: Шимохина НЮ, Харьков ЕИ, Таптыгина ЕВ, Балашова НА. Возможности повышения объективности оценки выполнения практических навыков на экзамене по дисциплине «Пропедевтика внутренних болезней». Сибирское медицинское обозрение. 2020;(1):55-59. DOI: 10.20333/2500136-2020-1-55-59
目的研究。2018年,俄罗斯医学部克拉斯诺亚尔斯克国立医科大学(接着是kragma)首次举办了三年级医学系医学系学生的“内伤培训”实证考试。本研究的目标是评估kragma医科三年级学生的实际技能,以及提高评估能力的能力。材料和方法。在第一轮考试中,402名学生和411名学生进行了示范。数据的统计分析使用了StatSoft Inc. 7.0应用程序包进行。结果。第一轮实践考试是在内病和治疗学部进行的。第二阶段最初是在kragma模拟技术中心的系里进行的。实践技能包括强制性部分:呼吸器官检查,心血管检查,消化系统检查。建议展示内分泌、尿道和其他系统的实用技能。在实践考试的第二阶段,可以提供另外三个额外的实践技能来演示。学生在第一阶段的平均成绩为4.0(3.6 - 4.7),第二阶段的平均成绩为4.7(4.3 - 5.0)。在实践考试的第二阶段,大多数学生因为展示了三种强制性的实践技能而获得“好”和“好”。囚犯。在实践考试的第二阶段,为了提高学生培训水平的客观性,建议引进独立的教师,使用模拟技术和专家评估表。关键词:内乱、医学系、实践考试、技能和技能、模拟中心、检查表。利益冲突。提交人声称,本文的出版没有明显和潜在的利益冲突。引文:shimohina nou, harikov ei, taptigina ev, balashova na。在“内部性疾病”学科考试中,有机会提高对实际技能的评估的客观性。西伯利亚医学评论2020;(1): 55 - 59。DOI: 10.20333/2500136 2020 - 1 - 55 - 59
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Journal of Software Maintenance and Evolution: Research and Practice
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