Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-6-70-74
S. M. Tsvinger, A. Govorin, A. M. Karachenova
The aim of the research is to study the content of some key pro / anti-inflammatory cytokines in patients with osteoarthritis and to evaluate their role in predicting atherogenesis in this category of patients. Material and methods. Patients with primary osteoarthritis of I-III radiological stages were examined. Doppler vessels ultrasound (Doppler ultrasound) of the neck, upper and lower extremities was performed; blood levels of pro / anti-inflammatory cytokines were examined: IL-1β, TNF-α, IL-6, IL- 8, IL-18, MCP-1, IL-17, IL-10, IL-33 by flow cytometry. Results. According to the thickness of intima - media complex, the patients were divided into 2 groups: with a normal thickness of intima - media complex and with atherosclerotic plaque. A significant increase in pro-inflammatory cytokines was revealed in patients with osteoarthritis associated with atherosclerosis compared with those having osteoarthritis with normal thickness of intima-media complex. The level of pro / anti-inflammatory cytokines along with atherosclerosis are closely interconnected. Conclusion. According to the results of the studies obtained, it was found that a long-term subclinical inflammatory process leads to multidirectional disturbances in cytokine balance in patients with osteoarthritis, which probably contributes to the progression of both osteoarthritis and atherosclerosis. A possible factor of early atherosclerosis development in patients with osteoarthritis was also identified.
{"title":"Features of cytokine balance in patients with osteoarthrosis and atherosclerosis","authors":"S. M. Tsvinger, A. Govorin, A. M. Karachenova","doi":"10.20333/2500136-2020-6-70-74","DOIUrl":"https://doi.org/10.20333/2500136-2020-6-70-74","url":null,"abstract":"The aim of the research is to study the content of some key pro / anti-inflammatory cytokines in patients with osteoarthritis and to evaluate their role in predicting atherogenesis in this category of patients. Material and methods. Patients with primary osteoarthritis of I-III radiological stages were examined. Doppler vessels ultrasound (Doppler ultrasound) of the neck, upper and lower extremities was performed; blood levels of pro / anti-inflammatory cytokines were examined: IL-1β, TNF-α, IL-6, IL- 8, IL-18, MCP-1, IL-17, IL-10, IL-33 by flow cytometry. Results. According to the thickness of intima - media complex, the patients were divided into 2 groups: with a normal thickness of intima - media complex and with atherosclerotic plaque. A significant increase in pro-inflammatory cytokines was revealed in patients with osteoarthritis associated with atherosclerosis compared with those having osteoarthritis with normal thickness of intima-media complex. The level of pro / anti-inflammatory cytokines along with atherosclerosis are closely interconnected. Conclusion. According to the results of the studies obtained, it was found that a long-term subclinical inflammatory process leads to multidirectional disturbances in cytokine balance in patients with osteoarthritis, which probably contributes to the progression of both osteoarthritis and atherosclerosis. A possible factor of early atherosclerosis development in patients with osteoarthritis was also identified.","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"1 1","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74991277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-4-97-107
K. Kononovich, Crafts, J. Macé
{"title":"Territory operational experience of maternity hospital users in Metropolitan France","authors":"K. Kononovich, Crafts, J. Macé","doi":"10.20333/2500136-2020-4-97-107","DOIUrl":"https://doi.org/10.20333/2500136-2020-4-97-107","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"17 1","pages":"97-107"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74622600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-1-20-26
N. Potapova, I. N. Gaymolenko, N. Strambovskaya
Цель исследования. Изучить роль ассоциации генотипов и аллелей полиморфизма BsmI гена VDR с вентиляционными нарушениями при бронхиальной астме у детей. Материал и методы. За период 2015-2017гг. обследовано 154 ребенка с бронхиальной астмой разной степени тяжести (73 ребенка с легким течением, 22 – со среднетяжелой и 59 – с тяжелой БА) и 34 относительно здоровых ребенка в качестве контрольной группы. Группы обследованных сопоставимы по полу и возрасту. Проведено молекулярно-генетическое типирование полиморфного локуса BsmI c.IVS.G>A гена рецептора VDR (rs1544410, G63980A). Результаты. Генотип GG полиморфизма BsmI c.IVS.G>A гена рецептора VDR встречается у пациентов с бронхиальной астмой в 4,4 раза чаще по сравнению со здоровыми индивидуумами (26,6 % против 6,0 %) (ОR=5,81, χ2=10,73, р=0,005). Генотип АА преобладает в группе контроля, составляя 53 % против 28 % у пациентов с БА. Не обнаружено статистических различий в частоте распределения генотипов и аллелей полиморфизма BsmI гена рецептора VDR у детей с разной степенью тяжести астмы. Носительство генотипа GG сопровождается резким снижением показателей ОФВ1 и ФЖЕЛ до 41 % и 43 % соответственно среди детей, больных бронхиальной астмой (р<0,05). Заключение. У детей с бронхиальной астмой отмечается более высокая частота встречаемости генотипа GG полиморфизма BsmI c.IVS.G>A гена рецептора VDR. Пациенты-носители генотипа GG полиморфизма G63980A гена VDR имеют резко выраженное снижение ОФВ1 и ФЖЕЛ, что возможно указывает на необратимые изменения архитектуры стенки бронхов и позволяет расценивать его как возможный предиктор вентиляционного дисбаланса при данном заболевании. Данный факт позволяет предполагать определенный вклад данного полиморфизма в реализацию структурной дезорганизации при ремоделировании дыхательных путей. Ключевые слова: бронхиальная астма, дети, полиморфизм гена VDR, вентиляционные нарушения. Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи. Для цитирования: Потапова НЛ, Гаймоленко ИН, Страмбовская НН. Ассоциация полиморфизма гена VDR и вентиляционного баланса при бронхиальной астме. Сибирское медицинское обозрение. 2020;(1):20-26. DOI: 10.20333/2500136-2020-1-20-26
{"title":"Association of VDR gene polymorphism and ventilation balance in bronchial asthma","authors":"N. Potapova, I. N. Gaymolenko, N. Strambovskaya","doi":"10.20333/2500136-2020-1-20-26","DOIUrl":"https://doi.org/10.20333/2500136-2020-1-20-26","url":null,"abstract":"Цель исследования. Изучить роль ассоциации генотипов и аллелей полиморфизма BsmI гена VDR с вентиляционными нарушениями при бронхиальной астме у детей. Материал и методы. За период 2015-2017гг. обследовано 154 ребенка с бронхиальной астмой разной степени тяжести (73 ребенка с легким течением, 22 – со среднетяжелой и 59 – с тяжелой БА) и 34 относительно здоровых ребенка в качестве контрольной группы. Группы обследованных сопоставимы по полу и возрасту. Проведено молекулярно-генетическое типирование полиморфного локуса BsmI c.IVS.G>A гена рецептора VDR (rs1544410, G63980A). Результаты. Генотип GG полиморфизма BsmI c.IVS.G>A гена рецептора VDR встречается у пациентов с бронхиальной астмой в 4,4 раза чаще по сравнению со здоровыми индивидуумами (26,6 % против 6,0 %) (ОR=5,81, χ2=10,73, р=0,005). Генотип АА преобладает в группе контроля, составляя 53 % против 28 % у пациентов с БА. Не обнаружено статистических различий в частоте распределения генотипов и аллелей полиморфизма BsmI гена рецептора VDR у детей с разной степенью тяжести астмы. Носительство генотипа GG сопровождается резким снижением показателей ОФВ1 и ФЖЕЛ до 41 % и 43 % соответственно среди детей, больных бронхиальной астмой (р<0,05). Заключение. У детей с бронхиальной астмой отмечается более высокая частота встречаемости генотипа GG полиморфизма BsmI c.IVS.G>A гена рецептора VDR. Пациенты-носители генотипа GG полиморфизма G63980A гена VDR имеют резко выраженное снижение ОФВ1 и ФЖЕЛ, что возможно указывает на необратимые изменения архитектуры стенки бронхов и позволяет расценивать его как возможный предиктор вентиляционного дисбаланса при данном заболевании. Данный факт позволяет предполагать определенный вклад данного полиморфизма в реализацию структурной дезорганизации при ремоделировании дыхательных путей. Ключевые слова: бронхиальная астма, дети, полиморфизм гена VDR, вентиляционные нарушения. Конфликт интересов. Авторы декларируют отсутствие явных и потенциальных конфликтов интересов, связанных с публикацией настоящей статьи. Для цитирования: Потапова НЛ, Гаймоленко ИН, Страмбовская НН. Ассоциация полиморфизма гена VDR и вентиляционного баланса при бронхиальной астме. Сибирское медицинское обозрение. 2020;(1):20-26. DOI: 10.20333/2500136-2020-1-20-26","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"208 1","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76089987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.15358/2511-8676-2020-2-3-70
Sascha Raithel, F. Jacob, M. Benkenstein
{"title":"Tuning the Sounds of Service: Essays in Honour of Michael Kleinaltenkamp","authors":"Sascha Raithel, F. Jacob, M. Benkenstein","doi":"10.15358/2511-8676-2020-2-3-70","DOIUrl":"https://doi.org/10.15358/2511-8676-2020-2-3-70","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"27 1","pages":"70-74"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76334783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-4-108-110
H.-W. Gessmann
{"title":"System-therapeutic view of the experience and behavior in children and adolescents","authors":"H.-W. Gessmann","doi":"10.20333/2500136-2020-4-108-110","DOIUrl":"https://doi.org/10.20333/2500136-2020-4-108-110","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"56 1","pages":"108-110"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75898851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-4-71-76
V. A. Lanina, A. V. Kuz’menko, Y. Vinnik, T. A. Gyaurgiev
{"title":"Сhronobiological features of females with symptoms of lower urinary tract","authors":"V. A. Lanina, A. V. Kuz’menko, Y. Vinnik, T. A. Gyaurgiev","doi":"10.20333/2500136-2020-4-71-76","DOIUrl":"https://doi.org/10.20333/2500136-2020-4-71-76","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"5 1","pages":"71-76"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78079201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-3-70-77
S. Lavrentev, M. Aksenenko, A. Averchuk, I. S. Zichenko
{"title":"miR-204-5p level modulation that induces formation of premetastatic niche in B16 melanoma in vivo model","authors":"S. Lavrentev, M. Aksenenko, A. Averchuk, I. S. Zichenko","doi":"10.20333/2500136-2020-3-70-77","DOIUrl":"https://doi.org/10.20333/2500136-2020-3-70-77","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"97 1","pages":"70-77"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81538516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-6-83-89
A. Ignatieva, O. F. Sibira, I. Gaimolenko
The aim of the research is to study the morbidity by appealability and some characteristics of congenital heart diseases in children of Zabaikalsky Territory. Material and methods. A retrospective clinical and anamnestic analysis of children with congenital heart diseases without surgical treatment, who were hospitalized, was carried out. The analysis included 3 year-observation. CHD diagnosed is an inclusion criterion; while surgical treatment of heart diseases is exclusion criterion. Statistical data processing was carried out using Microsoft Excel 2007, Statistica v.10.0 software package. χ2 test (Pearson) was used to compare two independent groups by qualitative characteristics. The results were considered statistically significant (reliable) at the achieved significance level of p <0.05. Results. In Zabaikalsky Territory, approximately 200 children with congenital heart disease without surgical treatment are hospitalized annually; the average age is 3 years. Fifty-three per cent of children applied for inpatient care for the first time, 44% of them were children at their first year. Gender distribution indicates the highest incidence of the pathology in girls. In CHD structure, atrial septal defects are on the first place, while interventricular septal defects are on the second. Combination of ASD and IVSD was observed with approximately equal frequency. Chronic heart failure associated with CHD was registered in 77% of children. In most cases CHF, stage 1, was diagnosed (63%). In 2/3 of cases, pulmonary hypertension of various severity was detected. Analysis of place of residence of children with CHD in the Zabaikalsky Territory shows that children from areas with the highest population density are hospitalized more often. Conclusion. The problem of congenital heart diseases in children of Zabaikalsky Territory is of current importance due to the widespread prevalence and high specific gravity among all internal organ defects in children of this region.
{"title":"Structure of unoperated congenital heart diseases in children of Zabaikalsky Territory","authors":"A. Ignatieva, O. F. Sibira, I. Gaimolenko","doi":"10.20333/2500136-2020-6-83-89","DOIUrl":"https://doi.org/10.20333/2500136-2020-6-83-89","url":null,"abstract":"The aim of the research is to study the morbidity by appealability and some characteristics of congenital heart diseases in children of Zabaikalsky Territory. Material and methods. A retrospective clinical and anamnestic analysis of children with congenital heart diseases without surgical treatment, who were hospitalized, was carried out. The analysis included 3 year-observation. CHD diagnosed is an inclusion criterion; while surgical treatment of heart diseases is exclusion criterion. Statistical data processing was carried out using Microsoft Excel 2007, Statistica v.10.0 software package. χ2 test (Pearson) was used to compare two independent groups by qualitative characteristics. The results were considered statistically significant (reliable) at the achieved significance level of p <0.05. Results. In Zabaikalsky Territory, approximately 200 children with congenital heart disease without surgical treatment are hospitalized annually; the average age is 3 years. Fifty-three per cent of children applied for inpatient care for the first time, 44% of them were children at their first year. Gender distribution indicates the highest incidence of the pathology in girls. In CHD structure, atrial septal defects are on the first place, while interventricular septal defects are on the second. Combination of ASD and IVSD was observed with approximately equal frequency. Chronic heart failure associated with CHD was registered in 77% of children. In most cases CHF, stage 1, was diagnosed (63%). In 2/3 of cases, pulmonary hypertension of various severity was detected. Analysis of place of residence of children with CHD in the Zabaikalsky Territory shows that children from areas with the highest population density are hospitalized more often. Conclusion. The problem of congenital heart diseases in children of Zabaikalsky Territory is of current importance due to the widespread prevalence and high specific gravity among all internal organ defects in children of this region.","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"101 1","pages":"83-89"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83840673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-4-92-96
A. U. Yagodina, S. Korotin, A. Petrachev
{"title":"Problem of informed consent personalization when providing dental services","authors":"A. U. Yagodina, S. Korotin, A. Petrachev","doi":"10.20333/2500136-2020-4-92-96","DOIUrl":"https://doi.org/10.20333/2500136-2020-4-92-96","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"83 1","pages":"92-96"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76854156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.20333/2500136-2020-3-86-91
N. Dovbysh, A. Gritsan, D. A. Kurnosov, N. A. Stepanenko
{"title":"The eff ect of inhaled anesthetics on jugular oximetry during aneurysms clipping of intracranial arteries","authors":"N. Dovbysh, A. Gritsan, D. A. Kurnosov, N. A. Stepanenko","doi":"10.20333/2500136-2020-3-86-91","DOIUrl":"https://doi.org/10.20333/2500136-2020-3-86-91","url":null,"abstract":"","PeriodicalId":17054,"journal":{"name":"Journal of Software Maintenance and Evolution: Research and Practice","volume":"42 1","pages":"86-91"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80819955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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