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Histologic findings of gastrointestinal biopsies and clinical outcome in dogs undergoing cholecystectomy for gallbladder mucoceles: 71 cases (2014-2021). 因胆囊粘液瘤接受胆囊切除术的狗的胃肠道活检组织学结果和临床预后:71 例病例(2014-2021 年)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-09-03 DOI: 10.1111/jsap.13781
M Gondolfe, E C Hans

Objectives: To determine the presence and categorise the severity of enteritis in dogs with gallbladder mucoceles, and evaluate for any associations with enteritis. This study also aimed to report clinical outcome following cholecystectomy and evaluate for associations with survival.

Materials and methods: Medical records were retrospectively reviewed (2014 to 2021) for dogs undergoing cholecystectomy and duodenal biopsy procedures for gallbladder mucocele. Signalment, bloodwork, abdominal ultrasound findings, surgical details, histology results and outcomes were reported. Surgeries were considered elective or emergent based on each dog's clinical presentation. Enteritis was categorised based on cell type and severity. Inflammation and clinical outcome were statistically evaluated.

Results: Seventy-one dogs met the study criteria. Enteritis was present in 85.9% (61/71) of cases with the majority being lymphoplasmacytic (53.5%). Twelve dogs (16.9%) underwent gastrointestinal biopsies from multiple sites, which revealed the same enteritis type at each location. A total of 87.3% (n = 62) dogs survived, including 90.4% elective and 86% emergent cases. No significant differences in enteritis severity or patient survival were found between elective and emergent cases. Septic peritonitis was diagnosed in two dogs (2.82%). Mortality was significantly associated with leukocytosis, with nonsurviving dogs having a mean WBC count of 27.6 G/L (95% confidence interval: 10.6 to 21.5).

Clinical significance: Enteritis is present in a majority of dogs with gallbladder mucocele, especially mild to moderate with lymphoplasmacytic cell type. Obtaining a duodenal biopsy had minimal impact on patient outcome. Compared to previous studies, improved survival in emergent cases was noted. Further studies with long-term follow-up are needed to determine if enteropathy-related signs persist after cholecystectomy.

目的:确定患有胆囊粘液瘤的狗是否患有肠炎以及肠炎的严重程度:确定患有胆囊粘液瘤的犬是否患有肠炎,并对肠炎的严重程度进行分类,同时评估与肠炎的关系。本研究还旨在报告胆囊切除术后的临床结果,并评估与存活率的关系:对因胆囊粘液瘤而接受胆囊切除术和十二指肠活检术的狗的病历进行回顾性审查(2014 年至 2021 年)。报告了信号、血液检查、腹部超声波检查结果、手术细节、组织学结果和治疗效果。手术根据每只狗的临床表现分为选择性手术和急诊手术。肠炎根据细胞类型和严重程度进行分类。对炎症和临床结果进行统计评估:结果:71 只犬符合研究标准。85.9%的病例(61/71)患有肠炎,其中大多数为淋巴细胞性肠炎(53.5%)。12 只狗(16.9%)接受了多个部位的胃肠活检,结果显示每个部位的肠炎类型相同。共有 87.3% 的狗(n = 62)存活下来,包括 90.4% 的选择性病例和 86% 的急诊病例。非急诊和急诊病例的肠炎严重程度和存活率没有明显差异。有两只狗(2.82%)被诊断为化脓性腹膜炎。死亡率与白细胞增多密切相关,非存活病例的平均白细胞计数为 27.6 G/L(95% 置信区间:10.6 至 21.5):临床意义:大多数患有胆囊粘液瘤的犬都会出现肠炎,尤其是轻度到中度的淋巴细胞型肠炎。进行十二指肠活检对患者的预后影响很小。与之前的研究相比,急诊病例的存活率有所提高。需要进一步开展长期随访研究,以确定胆囊切除术后与肠病相关的体征是否会持续存在。
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引用次数: 0
Computed tomographic re-evaluation of skeletally immature French bulldogs previously diagnosed with humeral intracondylar fissure: 12 cases (2018-2022) 曾被诊断为肱骨髁内裂的骨骼未成熟法国斗牛犬的计算机断层扫描再评估:12 个病例(2018-2022 年)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-14 DOI: 10.1111/jsap.13768
V. C. Hutchings, S. Rutherford

Objectives

The objective of this study was to present the follow-up findings obtained through computed tomography in skeletally immature French bulldogs previously diagnosed with humeral intracondylar fissures.

Materials and Methods

Medical records from a surgical referral centre between January 2018 and September 2022 were evaluated for all dogs with a humeral condylar fracture where preoperative CT of both humeri was performed. French bulldogs between the age of 12 weeks and 12 months were identified and evaluated for the presence of contralateral humeral intracondylar fissure. The dogs with follow-up CT were evaluated for humeral intracondylar fissure resolution.

Results

A total of 137 humeral condylar fractures were operated on within the study period, 58 of which were in French bulldogs. Twenty-seven French bulldogs had a contralateral humeral intracondylar fissure with 12 dogs matching the inclusion criteria. Follow-up CT demonstrated resolution of the humeral intracondylar fissure in 11 (91.7%) of 12 cases.

Clinical Significance

Contralateral humeral intracondylar fissures are common in skeletally immature French bulldogs sustaining humeral condylar fractures and the majority of these fissures tend to fuse within the follow-up period. Due to the potential for breed variation in ossification of the humeral condyle, follow-up CT may be warranted in skeletally immature French bulldogs before considering prophylactic transcondylar screw placement.

研究目的本研究的目的是通过计算机断层扫描,对之前被诊断为肱骨髁内裂的骨骼未成熟的法国斗牛犬进行随访:对一家外科转诊中心在 2018 年 1 月至 2022 年 9 月期间的医疗记录进行了评估,所有肱骨髁内骨折的犬均在术前进行了双肱骨 CT 检查。对年龄在 12 周到 12 个月之间的法国斗牛犬进行鉴定,并评估是否存在对侧肱骨髁内裂。对接受 CT 随访的犬只进行肱骨髁内裂隙消除情况评估:研究期间共对 137 只肱骨髁内骨折的狗进行了手术,其中 58 只为法国斗牛犬。27只法国斗牛犬的对侧肱骨髁内裂,其中12只符合纳入标准。随访 CT 显示,12 个病例中有 11 个(91.7%)的肱骨髁内裂隙已经愈合:临床意义:肱骨髁内对侧裂隙常见于肱骨髁骨折后骨骼尚未发育成熟的法国斗牛犬,大多数裂隙会在随访期内愈合。由于肱骨髁骨化可能存在品种差异,在考虑预防性经髁螺钉置入之前,可能需要对骨骼尚未发育成熟的法国斗牛犬进行后续 CT 检查。
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引用次数: 0
Ultrasonographic measurement of the prostatic dimension-to-aortic luminal diameter in healthy intact male dogs and dogs with benign prostatic hyperplasia 用超声波测量健康完整公犬和良性前列腺增生犬的前列腺尺寸与主动脉管腔直径。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-13 DOI: 10.1111/jsap.13766
S. Ponglowhapan, K. Pattanaviboon, Y. Maneerattanavichien, P. Phitchayangkoon, P. Lueangprasert, A. Preechatangkit, S. Suthigarn, P. Saisawart, C. Thanaboonnipat, N. Choisunirachon

Objectives

To establish ultrasonographic measurements of the prostatic dimension-to-aortic luminal diameter ratios including the prostatic volume-to-aortic luminal diameter ratio in healthy, intact male dogs and compare these ratios between healthy dogs and dogs affected by benign prostatic hyperplasia.

Materials and Methods

Healthy dogs (n = 75) and dogs affected by benign prostatic hyperplasia (n = 104) were included in the study. Prostate length, width, average height and aortic luminal diameter were measured from ultrasonographic images. In addition, prostatic volume was calculated, and prostatic volume-to-aortic luminal diameter were also compared.

Results

In healthy dogs, aortic luminal diameter was significantly associated with bodyweight and the prostatic width while body condition scores, prostate length and prostatic average height were not associated. Prostatic dimension-to-aortic luminal diameter ratios and prostatic volume-to-aortic luminal diameter ratio was not significantly different among dogs with different body condition scores either in healthy dogs or dogs affected by benign prostatic hyperplasia, except prostatic volume-to-aortic luminal diameter ratio in benign prostatic hyperplasia. Prostatic dimension-to-aortic luminal diameter ratios were significantly higher in benign prostatic hyperplasia while prostatic volume-to-aortic luminal diameter ratio significantly higher in healthy dogs. Prostatic dimension-to-aortic luminal diameter ratios demonstrated medium to high sensitivity and specificity when distinguishing between healthy dogs and dogs affected by benign prostatic hyperplasia. Prostatomegaly, should be considered when the prostatic dimension-to-aortic luminal diameter ratios increase. The calculated cut-off values were 3.68, 4.46 and 3.06 for prostate length-to-aortic luminal diameter, prostatic width- to-aortic luminal diameter and prostatic average height-to-aortic luminal diameter, respectively.

Clinical Significance

The prostatic dimension-to-aortic luminal diameter ratios could be useful to evaluate the size of the prostate in dogs, as it is unaffected by the body condition scores.

研究目的建立健康、完整雄性犬的前列腺尺寸与主动脉管腔直径比率(包括前列腺体积与主动脉管腔直径比率)的超声波测量值,并比较健康犬与良性前列腺增生症犬的这些比率。根据超声波图像测量前列腺的长度、宽度、平均高度和主动脉管腔直径。此外,还计算了前列腺体积,并对前列腺体积与主动脉管腔直径进行了比较:结果:在健康犬中,主动脉管腔直径与体重和前列腺宽度显著相关,而与身体状况评分、前列腺长度和前列腺平均高度无关。无论是健康犬还是良性前列腺增生症犬,前列腺尺寸与主动脉管腔直径之比以及前列腺体积与主动脉管腔直径之比在不同体况评分的犬之间没有明显差异,但良性前列腺增生症犬的前列腺体积与主动脉管腔直径之比除外。良性前列腺增生症犬的前列腺体积与主动脉管腔直径之比显著高于健康犬,而前列腺体积与主动脉管腔直径之比显著高于健康犬。在区分健康犬和良性前列腺增生症犬时,前列腺体积与主动脉管腔直径之比显示出中等到较高的灵敏度和特异性。当前列腺尺寸与主动脉管腔直径比值增大时,应考虑前列腺肥大。计算得出的前列腺长度与主动脉管腔直径、前列腺宽度与主动脉管腔直径和前列腺平均高度与主动脉管腔直径的临界值分别为 3.68、4.46 和 3.06:前列腺尺寸与主动脉管腔直径之比可以用来评估狗的前列腺大小,因为它不受身体状况评分的影响。
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引用次数: 0
Clinical experience and outcomes using a commercially available micro-plating system for metabone fractures in dogs and cats: 10 cases (2019-2023) 使用市售微型电镀系统治疗猫狗代谢骨骨折的临床经验和效果:10 个病例(2019-2023 年)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-08 DOI: 10.1111/jsap.13767
D. M. Marturello, K. L. Perry

Objectives

To report the clinical experience and long-term outcome following metabone fracture stabilisation using a commercially available micro-plating system (VetKISS, 1.0-mm, IMEX Veterinary, USA).

Materials and Methods

Consecutive, client-owned cats and dogs weighing <7 kg, with traumatic metabone fractures stabilised using VetKISS micro-plates were prospectively enrolled with informed owner consent. Clinical and radiographic parameters were recorded. Either short-term or long-term clinical and radiographic follow-up was required for study inclusion.

Results

Four cats and six dogs were enrolled and operated by one of two board-certified surgeons. Bodyweight ranged from 1.9 to 6.6 kg. Number of metabones fractured: all four (60%), three (30%) and two (10%). Anatomical alignment was restored for each metabone. External coaptation was not used in any case. Radiographic follow-up documented clinical or bony union in all cases. Mean time to clinical union was 51 days. One major complication (screw removal) and two minor complications (partial construct failure) were observed. All patients made a complete functional recovery at the time of documented union. Long-term follow-up was available in five cases. No lameness (evaluated independently by both surgeons) or plate sensitivity was noted.

Clinical Significance

This is the first clinical evaluation of the VetKISS for metabone fracture repair, and includes long-term follow-up. Results demonstrated complete functional recovery and 100% clinical union rates in all patients, with acceptable complication rates. This system can be considered for metabone repair in patients weighing <7 kg without the use of external coaptation.

目的报告使用市售微电镀系统(VetKISS,1.0 毫米,美国 IMEX 兽医公司)稳定 metabone 骨折后的临床经验和长期疗效:材料和方法:连续测量客户饲养的猫和狗的体重:四只猫和六只狗被选中,由两名获得认证的外科医生之一进行手术。体重从 1.9 千克到 6.6 千克不等。骨折的代谢骨数量:全部四根(60%)、三根(30%)和两根(10%)。每根代谢骨都恢复了解剖对齐。所有病例均未使用外固定。所有病例的X光片随访均显示有临床或骨性结合。平均临床愈合时间为 51 天。观察到一个主要并发症(螺钉移除)和两个次要并发症(部分结构失败)。所有患者都在有记录的骨结合时完全恢复了功能。有五例患者接受了长期随访。未发现跛行(由两名外科医生独立评估)或钢板敏感现象:临床意义:这是首次对 VetKISS 进行代谢骨骨折修复的临床评估,包括长期随访。结果表明,所有患者的功能完全恢复,临床愈合率达 100%,并发症发生率也在可接受范围内。该系统可用于体重较重患者的代谢骨修复。
{"title":"Clinical experience and outcomes using a commercially available micro-plating system for metabone fractures in dogs and cats: 10 cases (2019-2023)","authors":"D. M. Marturello,&nbsp;K. L. Perry","doi":"10.1111/jsap.13767","DOIUrl":"10.1111/jsap.13767","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To report the clinical experience and long-term outcome following metabone fracture stabilisation using a commercially available micro-plating system (VetKISS, 1.0-mm, IMEX Veterinary, USA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Consecutive, client-owned cats and dogs weighing &lt;7 kg, with traumatic metabone fractures stabilised using VetKISS micro-plates were prospectively enrolled with informed owner consent. Clinical and radiographic parameters were recorded. Either short-term or long-term clinical and radiographic follow-up was required for study inclusion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Four cats and six dogs were enrolled and operated by one of two board-certified surgeons. Bodyweight ranged from 1.9 to 6.6 kg. Number of metabones fractured: all four (60%), three (30%) and two (10%). Anatomical alignment was restored for each metabone. External coaptation was not used in any case. Radiographic follow-up documented clinical or bony union in all cases. Mean time to clinical union was 51 days. One major complication (screw removal) and two minor complications (partial construct failure) were observed. All patients made a complete functional recovery at the time of documented union. Long-term follow-up was available in five cases. No lameness (evaluated independently by both surgeons) or plate sensitivity was noted.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>This is the first clinical evaluation of the VetKISS for metabone fracture repair, and includes long-term follow-up. Results demonstrated complete functional recovery and 100% clinical union rates in all patients, with acceptable complication rates. This system can be considered for metabone repair in patients weighing &lt;7 kg without the use of external coaptation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"65 10","pages":"770-775"},"PeriodicalIF":1.7,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.13767","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outcome of treatment with a 10-week COP protocol in cats with intermediate or large cell lymphoma: 27 cases (2014-2023) 对患有中型或大型细胞淋巴瘤的猫采用为期 10 周的 COP 方案进行治疗的结果:27 例病例(2014-2023 年)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-07 DOI: 10.1111/jsap.13772
M. M. E. Larsen, A.-M. Andersson, M. Arendt

Objectives

The aim of this retrospective clinical study was to evaluate and report response to treatment with a 10-week maintenance-free COP (COP-10) protocol in a cohort of 27 cats with intermediate or large cell lymphoma. Additionally, to identify any potential prognostic factors for predicting the treatment response.

Materials and Methods

The medical records of cats diagnosed with intermediate or large cell lymphoma in a single institution in the period 2014 to 2023 and treated with COP-10 as first-line treatment were reviewed.

Results

Twenty-seven cats were included in the study. The median age was 10 years, 67% of the cats were in stages I to II and the most common anatomical location was alimentary (37%). The overall response rate was 65%, with 38% of cats achieving complete remission and 27% partial remission. For cats achieving complete remission, the median progression-free interval and the median lymphoma-specific survival time were both 1,139 days. For cats in partial remission, the median progression-free interval and the median lymphoma-specific survival time were 53 and 210 days, respectively. Clinical stage was significantly related to treatment response and survival time.

Clinical Significance

Treatment with the short protocol COP-10 resulted in remission rates and durable first remissions for cats achieving complete remission comparable to responses seen with longer-duration chemotherapy protocols. The results from this study may impact economic and logistic decisions for owners, as well as the quality of life for patients in the future.

研究目的这项回顾性临床研究旨在评估和报告27只患有中型或大型细胞淋巴瘤的猫对10周免维持COP(COP-10)方案治疗的反应。此外,研究还旨在确定预测治疗反应的潜在预后因素:回顾2014年至2023年期间在一家机构确诊为中型或大型细胞淋巴瘤并接受COP-10作为一线治疗的猫的病历:研究共纳入27只猫。中位年龄为10岁,67%的猫处于I期至II期,最常见的解剖位置是消化道(37%)。总体反应率为 65%,其中 38% 的猫完全缓解,27% 部分缓解。获得完全缓解的猫的中位无进展间隔时间和中位淋巴瘤特异生存时间均为 1,139 天。对于部分缓解的猫,中位无进展间隔时间和中位淋巴瘤特异生存时间分别为53天和210天。临床分期与治疗反应和生存时间明显相关:临床意义:采用COP-10短方案治疗后,获得完全缓解的猫的缓解率和持久的首次缓解率与采用较长时间化疗方案的反应相当。这项研究的结果可能会影响饲主的经济和后勤决策,以及患者未来的生活质量。
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引用次数: 0
Surgical treatment and outcome of primary rib tumours in cats: eight cases (2016-2023) 猫原发性肋骨肿瘤的手术治疗和结果:八例病例(2016-2023)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-07 DOI: 10.1111/jsap.13770
F. Cinti, M. Martano, M. Rossanese, L. E. Selmic, G. S. Fontes, M. Cino, V. Montinaro, G. Tremolada

Objectives

To describe the clinical features and oncologic outcome for cats with primary rib tumours.

Materials and Methods

Medical records for cats with surgically treated primary rib tumours from six veterinary referral centres were reviewed. Signalment, preoperative clinical signs, reconstruction technique, and surgical and oncologic outcome were retrieved from medical records or by telephone interview with owners and/or referring veterinarians.

Results

Of the eight cats with primary rib tumours, three had hemangiosarcoma, two had osteosarcoma and one cat each had chondrosarcoma, osteochondroma and osteoma. The size of the primary rib mass ranged from 2 × 2 × 1.6 cm to 9 × 7 × 7.5 cm. Three minor and one major complication developed during the immediate post-operative period. Surgery consisted of thoracic wall resection in all cats. All animals survived the procedure and the median time to discharge was 3 days. The survival time for benign tumours was 150 (case 5) and 466 (case 4) days, while for malignant tumours ranged from 105 to 550 days (cases 1 to 3, cases 6 to 8).

Clinical Significance

Hemangiosarcoma and osteosarcoma were the most represented primary rib tumours in this cohort of cats. Wide surgical excision and adjuvant chemotherapy is recommended for cats with hemangiosarcoma and osteosarcoma, but the prognosis remains guarded. Prognosis appears to be fair for the other tumour types.

目的:描述原发性肋骨肿瘤猫的临床特征和肿瘤治疗结果:描述原发性肋骨肿瘤猫的临床特征和肿瘤治疗结果:回顾六家兽医转诊中心接受手术治疗的原发性肋骨肿瘤猫的病历。信号、术前临床症状、重建技术、手术和肿瘤结果均来自医疗记录,或通过电话采访猫主人和/或转诊兽医获得:结果:八只患有原发性肋骨肿瘤的猫中,三只患有血管肉瘤,两只患有骨肉瘤,软骨肉瘤、骨软骨瘤和骨瘤各一只。原发性肋骨肿块的大小从 2 × 2 × 1.6 厘米到 9 × 7 × 7.5 厘米不等。术后即刻出现了三种轻微并发症和一种严重并发症。所有猫的手术都是胸壁切除术。所有动物均在手术中存活,中位出院时间为 3 天。良性肿瘤的存活时间为150天(病例5)和466天(病例4),恶性肿瘤的存活时间为105天至550天(病例1至3,病例6至8):临床意义:血管肉瘤和骨肉瘤是该组猫中最常见的原发性肋骨肿瘤。建议对患有血管肉瘤和骨肉瘤的猫进行广泛的手术切除和辅助化疗,但预后仍不乐观。其他肿瘤类型的预后似乎尚可。
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引用次数: 0
Evaluation of presentation, treatment and outcome in dogs with granulomatous steatitis associated with hypercalcaemia: six cases (2019-2023) 评估伴有高钙血症的肉芽肿性脂肪炎症犬的表现、治疗和结果:六个病例(2019-2023年)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-07 DOI: 10.1111/jsap.13771
H. Reyes-Hughes, A. Bivand, C. Waters, P. Valiente, F. Adam, S. Rapastella, E. N. Barker

Objectives

To report the presentation, treatment and outcome of dogs with granulomatous steatitis associated with total and ionised hypercalcaemia.

Methods

Six dogs diagnosed with ionised and/or total hypercalcaemia and histologically diagnosed granulomatous steatitis were evaluated to determine the clinical signs, clinical findings, response to treatment and outcome. These cases were seen at different primary care and referral veterinary hospitals in the United Kingdom between 2019 and 2023.

Results

No alternative aetiology to explain the total and/or ionised hypercalcaemia or steatitis was identified. The most common presenting signs were lethargy, anorexia or hyporexia, vomiting and polyuria/polydipsia. Other clinical signs included weight loss, discomfort and panting. Five out of the six dogs responded to prednisolone. Four dogs were alive at the time of writing, one dog was lost to follow-up and one dog died 2 weeks post-diagnosis.

Clinical Significance

It is well-established that granulomatous disease can cause hypercalcaemia. In this case series we found granulomatous steatitis associated with total and/or ionised hypercalcaemia. Dogs diagnosed with granulomatous steatitis should have ionised calcium measured, which may prompt further diagnostics and treatment options. Dogs with hypercalcaemia should be evaluated for evidence of steatitis where more common differentials have been excluded.

目的:报告肉芽肿性脂肪炎伴有全血细胞和离子化高钙血症的狗的表现、治疗和结果:报告患有肉芽肿性脂肪炎并伴有全高钙血症和离子化高钙血症的狗的表现、治疗和结果:对六只被诊断为离子化和/或全高钙血症并经组织学诊断为肉芽肿性脂肪炎的狗进行评估,以确定其临床症状、临床发现、对治疗的反应和结果。这些病例于2019年至2023年期间在英国不同的初级保健和转诊兽医院就诊:总和/或离子型高钙血症或脂肪性肝炎的病因均未找到。最常见的临床症状是嗜睡、厌食或低厌食、呕吐和多尿/多饮。其他临床症状包括体重减轻、不适和气喘。六只狗中有五只对泼尼松龙有反应。在撰写本报告时,四只狗还活着,一只狗失去了随访机会,一只狗在确诊后两周死亡:肉芽肿病可导致高钙血症,这一点已得到公认。在本病例系列中,我们发现肉芽肿性脂肪炎与总钙和/或离子化高钙血症有关。确诊为肉芽肿性脂肪炎的犬应进行离子钙测量,这可能会提示进一步的诊断和治疗方案。在排除了更常见的鉴别因素后,应对患有高钙血症的犬只进行脂肪性肝炎证据评估。
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引用次数: 0
Persistent left cranial vena cava in a dog 一只狗的左颅腔静脉持续存在。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-06 DOI: 10.1111/jsap.13765
Z. Yilmaz, M. Kocaturk, J. Koch

A 10-year-old golden retriever was presented for the evaluation of exercise intolerance. Physical examination and laboratory tests showed no abnormalities except for mild anaemia. Standard transthoracic echocardiography revealed dilated coronary sinus, raising suspicion of a persistent left cranial vena cava, and the persistency of this anomaly was confirmed by agitated-saline study. Right ventricular echocardiographic parameters did not change significantly, while conventional parameters and global longitudinal strain analysis revealed left ventricular systolic dysfunction. Moreover, post-systolic shortening and early systolic lengthening were detected by two-dimensional speckle tracking echocardiography. This report shows that post-systolic shortening and early systolic lengthening may be useful diagnostic markers indicating regional left ventricular systolic dysfunction. Further studies are needed to elucidate whether persistent left cranial vena cava contributes to left ventricular systolic dysfunction or is an accidental benign finding in dogs.

一只 10 岁大的金毛猎犬因运动不耐受前来接受评估。体格检查和实验室检查结果显示,除了轻度贫血外,没有其他异常。标准的经胸超声心动图显示冠状动脉窦扩张,引起了对左颅腔静脉持续存在的怀疑。右心室超声心动图参数无明显变化,而常规参数和整体纵向应变分析显示左心室收缩功能障碍。此外,二维斑点追踪超声心动图还发现了收缩期后缩短和收缩早期延长。该报告表明,收缩后缩短和收缩早期延长可能是表明区域性左心室收缩功能障碍的有用诊断标志物。还需要进一步研究,以阐明持续存在的左颅腔静脉是导致左心室收缩功能障碍的原因,还是狗的偶然良性发现。
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引用次数: 0
Intravesical urinary bladder duplication in a dog 一只狗的膀胱内重复。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-06 DOI: 10.1111/jsap.13769
M. J. R. Jacqmin, C. Baudin Tréhiou, A. Tortereau, P. Pillard
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引用次数: 0
A rapid manual technique does not have adequate sensitivity and specificity to reliably discriminate between neutropenic and non-neutropenic dogs prior to administration of chemotherapy. 快速人工技术不具备足够的灵敏度和特异性,无法在化疗前可靠地区分中性粒细胞减少和非中性粒细胞减少的狗。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-08-06 DOI: 10.1111/jsap.13773
M Walton-Clark, T Henriques, M Best

Objectives: To develop and determine the accuracy of a rapid manual technique for the detection of pre-treatment neutropenia (<1.50 × 109/L) in dogs receiving chemotherapy.

Materials and methods: Twenty canine blood smears with known neutrophil counts between 1.00 × 109/L and 3.00 × 109/L were reviewed by two internal medicine clinicians and linear regressions performed to determine a cut-off value for a manual neutrophil count equating to >1.50 × 109/L. Consecutive blood samples from dogs undergoing chemotherapy were processed through an automated haematology analyser (VetScan HM5, Abaxis), and prospective blinded manual review by the same two observers assessed whether the manual technique could accurately detect dogs with neutropenia.

Results: Linear regression analysis found a cut-off of >26 neutrophils per 10 low power fields at the monolayer to be equivalent to a neutrophil count of >1.5 × 109/L. A total of 183 blood samples from 43 dogs were reviewed. Automated techniques detected neutropenia in 16 of 183 (9%) blood samples. Using the manual cut-off technique, 13 of 16 (81%) and 11 of 16 (69%) of neutropenic samples were correctly identified by observer 1 and observer 2, respectively. Twenty-three of 167 non-neutropenic dogs (14%) were incorrectly classified as neutropenic by observer 1, and 27 (16%) by observer 2. Inter-observer agreement was 92%. Sensitivity was 81% (95% confidence interval 54% to 96%) for observer 1 and 69% (95% confidence interval 41% to 89%) for observer 2. Specificity was 86% (95% confidence interval 80% to 91%) for observer 1 and 84% (95% confidence interval 77% to 89%) for observer 2.

Clinical significance: Manual estimation resulted in up to five of 16 (31%) neutropenic samples being incorrectly classified. A full automated differential cell count remains preferable.

目的材料与方法:由两名内科临床医生对 20 份已知中性粒细胞计数在 1.00 × 109/L 和 3.00 × 109/L 之间的犬血液涂片进行审查,并进行线性回归,以确定中性粒细胞计数(9/L)的临界值:由两名内科临床医生对已知中性粒细胞计数在 1.00 × 109/L 和 3.00 × 109/L 之间的 20 份犬血液涂片进行复查,并进行线性回归,以确定人工中性粒细胞计数大于 1.50 × 109/L 的临界值。通过自动血液分析仪(VetScan HM5,Abaxis)处理接受化疗的犬的连续血液样本,并由同两名观察员进行前瞻性盲法人工审核,以评估人工技术是否能准确检测出患有中性粒细胞减少症的犬:线性回归分析发现,单层每 10 个低倍视野中嗜中性粒细胞数大于 26 个的临界值相当于嗜中性粒细胞数大于 1.5 × 109/L。共对 43 只狗的 183 份血液样本进行了审查。在 183 份血样中,有 16 份(9%)通过自动技术检测出中性粒细胞减少症。观察者 1 和观察者 2 使用手动截断技术分别正确识别了 16 份中性粒细胞减少样本中的 13 份(81%)和 11 份(69%)。在 167 只非中性粒细胞减少的狗中,有 23 只(14%)被观察者 1 错误地归类为中性粒细胞减少,27 只(16%)被观察者 2 错误地归类为中性粒细胞减少。观察者之间的一致性为 92%。观察者 1 的灵敏度为 81%(95% 置信区间为 54% 至 96%),观察者 2 的灵敏度为 69%(95% 置信区间为 41% 至 89%)。特异性方面,观察者 1 为 86%(95% 置信区间为 80%-91%),观察者 2 为 84%(95% 置信区间为 77%-89%):人工估算导致 16 份中性粒细胞样本中有多达 5 份(31%)被错误分类。全自动差值细胞计数仍然更可取。
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引用次数: 0
期刊
Journal of Small Animal Practice
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