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Outcome of dogs diagnosed with concurrent intrahepatic portosystemic shunts and vertebral lesions: six cases (2016-2022) 被诊断同时患有肝内门体分流和脊椎病变的狗的结果:六个病例(2016-2022 年)。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-28 DOI: 10.1111/jsap.13725
F. P. Solari, J. B. Case, F. R. Vilaplana Grosso, W. T. N. Culp

Objectives

To describe the clinical outcome of dogs diagnosed with concurrent discospondylitis/vertebral physitis and congenital intrahepatic portosystemic shunts.

Materials and Methods

Medical records from two academic institutions were searched for dogs diagnosed with discospondylitis and/or vertebral physitis, and a concurrent intrahepatic portosystemic shunt. Dogs were excluded if they did not undergo attenuation of their shunt, did not have a single congenital intrahepatic shunt and did not have at least 90 days of follow-up.

Results

Six dogs met the inclusion criteria and were included in the study. Discospondylitis alone was diagnosed in four dogs, vertebral physitis alone in one dog and both discospondylitis and vertebral physitis in one dog. Three dogs had a right divisional intrahepatic portosystemic shunt, and three dogs had a left divisional intrahepatic portosystemic shunt. Median duration of antimicrobial therapy was 112 days (range 14 to 240 days). Clinical resolution of discospondylitis and vertebral physitis was noted in all dogs. Endovascular attenuation was performed in all dogs a median of 82 days after presentation (range 1 to 317 days). No perioperative or postoperative complications occurred. All dogs were alive at the last available follow-up a median of 513 days after presentation (range 224 to 1504 days) and free of clinical signs associated with discospondylitis or vertebral physitis, as well as their portosystemic shunt.

Clinical Significance

Dogs with intrahepatic portosystemic shunts may concurrently develop discospondylitis and vertebral physitis. With antimicrobial therapy and endovascular embolisation of their portosystemic shunt, all dogs in this study had a good outcome with clinical resolution of both disease processes. However, long-term follow-up was not obtained in all cases.

目的描述被诊断同时患有椎间盘炎/椎体炎和先天性肝内门体系统分流的犬的临床结果:检索两家学术机构的医疗记录,以查找被诊断患有椎间盘炎和/或椎体炎以及同时患有肝内门体系统分流的犬只。如果狗没有进行分流衰减、没有单个先天性肝内分流且没有至少 90 天的随访,则排除在外:结果:六只狗符合纳入标准并被纳入研究。四只狗被诊断为单纯盘骨炎,一只狗被诊断为单纯椎体炎,一只狗同时被诊断为盘骨炎和椎体炎。三只狗患有右分流肝内门体分流术,三只狗患有左分流肝内门体分流术。抗菌治疗的中位持续时间为 112 天(14 天至 240 天不等)。所有狗狗的椎间盘炎和脊椎炎都得到了临床治愈。所有病犬均在发病后中位 82 天(1 到 317 天不等)接受了血管内减压术。没有发生围手术期或术后并发症。在发病后中位数为 513 天(224 天到 1504 天不等)的最后一次随访中,所有病犬均存活,并且没有出现与椎间盘炎或椎体炎相关的临床症状,也没有出现门静脉分流:临床意义:患有肝内门体系统分流术的犬可能会同时患上椎间盘炎和椎体炎。通过抗菌治疗和血管内栓塞门静脉分流术,本研究中的所有病犬都获得了良好的治疗效果,两种疾病都得到了临床缓解。不过,并非所有病例都能获得长期随访。
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引用次数: 0
Malignant peripheral nerve sheath tumour of the cerebellopontine angle in a cat 一只猫的小脑角恶性周围神经鞘瘤。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-12 DOI: 10.1111/jsap.13714
M. N. Çetin, Y. S. Şirin, A. Milletsever, M. Y. Şirin, V. Ipek

Malignant peripheral nerve sheath tumour is an uncommon tumour in cats. The current case report aims to present the diagnosis, treatment and histopathology of a malignant peripheral nerve sheath tumour that developed in the cerebellopontine angle region of a cat. A 4-year-old 4.2-kg female calico cat was brought to the animal hospital with the complaints of loss of balance, leaning against the wall and behavioural changes. During the neurological examination, the patient was observed to have a right-sided head tilt accompanied by ipsilateral ventral strabismus. On magnetic resonance imaging scan, a mass was identified at the right cerebellopontine angle. The surgical removal of the mass was carried out using a caudo-tentorial approach. The histopathological analysis revealed the presence of a malignant peripheral nerve sheath tumour. This case report contributes to the existing knowledge in the field presenting the characteristics of a malignant peripheral nerve tumour that was not associated with any nerve in the cerebellopontine angle in a cat.

恶性周围神经鞘瘤是猫科动物中一种不常见的肿瘤。本病例报告旨在介绍发生在猫小脑角区域的恶性周围神经鞘瘤的诊断、治疗和组织病理学。一只 4 岁、体重 4.2 千克的雌性花猫被送到动物医院,主诉失去平衡、靠在墙上和行为改变。在进行神经系统检查时,发现患者头部右侧倾斜,并伴有同侧腹侧斜视。磁共振成像扫描发现,右侧小脑角有肿块。手术采用尾状腱膜入路切除肿块。组织病理学分析显示,该患者患有恶性周围神经鞘瘤。本病例报告介绍了猫小脑角恶性周围神经鞘瘤的特征,有助于丰富该领域的现有知识。
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引用次数: 0
Bilateral simple ectopic kidney with congenital portosystemic shunt and caudal vena cava with azygos continuation in a dog 一只狗的双侧单纯异位肾伴有先天性门静脉分流和带颧骨延续的尾腔静脉。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-10 DOI: 10.1111/jsap.13723
S. Mikawa, N. Akashi, R. Yoshitake, K. Kutara
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引用次数: 0
Successful centralisation technique for treatment of post-traumatic absence of the radial shaft in a dog 成功采用集中化技术治疗狗的桡骨轴外伤后缺失。
IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-09 DOI: 10.1111/jsap.13712
P. Camilletti, M. d'Amato

This report describes a centralisation procedure for the treatment of a radial non-union, characterised by extensive bone loss and an intact ulna, in an 18-month-old toy poodle. A lateral approach to the radius/ulna shafts was realised and, after debridement of the non-union site, an ulnar osteotomy was performed proximal to the styloid process of the ulna. Transposition of the distal fragment of the radius to the distal end of the osteotomised proximal segment of the ulna was performed and the stabilisation was obtained using a locking plate with proximal screws in the ulnar shaft and distal screws in the radius epiphysis. The patient achieved bone union in 10 weeks and the last evaluation, performed 112 weeks postoperatively, showed a full return to pre-injury function. Based on the results of this report, the centralisation was effective in the treatment of post-traumatic absence of the radial shaft in a dog.

本报告描述了一种集中化手术,用于治疗一只 18 个月大的玩具贵宾犬的桡骨不连接,其特点是骨质大量流失,尺骨完好无损。手术采用桡骨/尺骨轴外侧入路,在对桡骨骨不连部位进行清创后,在尺骨花键突近端进行尺骨截骨术。将桡骨远端碎片移位到截骨后的尺骨近端,并使用锁定钢板进行稳定,锁定钢板的近端螺钉固定在尺骨轴上,远端螺钉固定在桡骨骨骺上。患者在 10 周内实现了骨结合,术后 112 周进行的最后一次评估显示,患者完全恢复了受伤前的功能。根据本报告的结果,集中化手术对治疗狗的桡骨轴创伤后缺失非常有效。
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引用次数: 0
Intramural gastric abscesses in a dog 一只狗的胃内脓肿。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-05 DOI: 10.1111/jsap.13713
I. Otero Balda, M. Augusto, C. Lassaigne, M. P. Maurin

A 6-year-old, female neutered Labrador retriever was presented with a chronic history of vomiting and anorexia. Abdominal ultrasound identified two large cavitated structures with echogenic content in the gastric fundus and pyloric region. CT revealed the intraparietal nature of these structures, one in the greater curvature and another one extending from the lesser curvature to the pyloric antrum. Surgical exploration revealed two areas of thickened gastric wall with intramural purulent material. Debridement and partial resection of the abscess (deroofing) were performed via a routine gastrotomy approach. Histopathology of a gastric wall sample revealed neutrophilic inflammation with intralesional vegetal foreign body. The presence of intralesional foreign body with a positive bacterial culture and macroscopic absence of peritonitis may suggest an intramural migrating vegetal foreign body. Gastric wall abscess should be included in a differential diagnosis in dogs with a history of chronic vomiting and the presence of gastric wall cavitated structures. Surgical debridement through a routine gastrotomy opening alleviated the clinical signs related to the intramural gastric abscesses in this dog with no recurrence at 22 months.

患者是一只 6 岁的雌性阉割拉布拉多猎犬,长期呕吐和厌食。腹部超声波检查发现,在胃底和幽门区域有两个巨大的空腔结构,并伴有回声内容物。CT 显示这些结构为顶内结构,一个位于胃大弯,另一个从胃小弯延伸至幽门窦。手术探查发现两处胃壁增厚,内有脓性物质。通过常规胃切除术方法对脓肿进行了清创和部分切除(去脓肿)。胃壁样本的组织病理学检查显示,胃壁有中性粒细胞炎症,内含植物性异物。胃壁内异物伴细菌培养阳性,且宏观上无腹膜炎,这可能提示胃壁内移行性植物异物。对于有慢性呕吐史和胃壁空腔结构的犬,应将胃壁脓肿列入鉴别诊断。通过常规胃切开术进行的手术清创缓解了该犬与胃壁内脓肿有关的临床症状,并且在 22 个月后没有复发。
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引用次数: 0
Transient myocardial thickening after routine ovariohysterectomy in a 15-month-old Ragdoll cat 一只 15 个月大的布偶猫在常规卵巢切除术后出现一过性心肌增厚。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-05 DOI: 10.1111/jsap.13722
Y. Wang, J. Seo

A 15-month-old female Ragdoll cat was evaluated for progressive lethargy, tachypnoea and increased respiratory effort for 1 week after routine ovariohysterectomy. Thoracic radiographs and an echocardiogram showed evidence of congestive heart failure and a hypertrophic cardiomyopathy phenotype, respectively. The maximum left ventricular wall thickness in end diastole was 6.2 mm. The serum cardiac troponin I concentration was 20.86 ng/mL. The cat was treated with furosemide and clopidogrel and discharged after 3 days. A repeat echocardiogram 2 weeks later showed complete resolution of the hypertrophic cardiomyopathy phenotype (maximum left ventricular wall thickness: 5.0 mm). A repeat cardiac troponin I concentration was 0.041 ng/mL. All cardiac medications were discontinued. A final recheck 4 weeks later revealed stable normal echocardiogram and further reduction in cardiac troponin I concentration to 0.004 ng/mL. This case report demonstrates that resolution of transient myocardial thickening can take 2 weeks after the echocardiographic diagnosis of left ventricular thickening.

一只 15 个月大的雌性布偶猫在例行卵巢切除术后一周出现了逐渐嗜睡、呼吸急促和呼吸困难的症状。胸片和超声心动图分别显示充血性心力衰竭和肥厚型心肌病表型。舒张末期左心室壁最大厚度为 6.2 毫米。血清心肌肌钙蛋白 I 浓度为 20.86 纳克/毫升。该猫接受了呋塞米和氯吡格雷治疗,3 天后出院。2 周后再次进行超声心动图检查,结果显示肥厚型心肌病表型完全消失(左心室壁最大厚度:5.0 毫米)。复查的心肌肌钙蛋白 I 浓度为 0.041 纳克/毫升。所有心脏病药物均已停用。4 周后的最后一次复查显示超声心动图稳定正常,心肌肌钙蛋白 I 浓度进一步降至 0.004 纳克/毫升。本病例报告表明,一过性心肌增厚可在超声心动图诊断为左心室增厚两周后才得到缓解。
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引用次数: 0
Recording of suspected adverse drug reaction reporting in veterinary free-text clinical narratives 在兽医自由文本临床叙述中记录疑似药物不良反应报告。
IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-05 DOI: 10.1111/jsap.13721
H. Davies, E. Blackwell, I. S. Fins, P. J. M. Noble, G. Pinchbeck, M. Pirmohamed, D. R. Killick

Objectives

To use text mining approaches to identify instances of suspected adverse drug reactions recorded in first opinion veterinary free-text clinical narratives, and to evaluate whether these were also reported to either the Veterinary Medicines Directorate or the relevant Marketing Authorisation holder in order to derive an estimate of the suspected adverse drug reaction (sADR) minimum under-reporting rate. To characterise sADR reports and explore whether particular features are associated with report submission.

Materials and Methods

Two regular expressions were developed to identify mentions of “adverse drug reactions” and “side effects” in the free-text clinical narratives of electronic health records contained within the Small Animal Veterinary Surveillance Network database. Consultations containing a match for the developed regular expressions were manually reviewed for inclusion and further classified to determine the suspected product, seriousness and expectedness of the event, and an indication of whether the event had been reported. The associations between event characteristics and reporting were explored using Fisher's exact tests.

Results

A total of 10,565 records were manually reviewed from which 827 sADRs were identified. Approximately 90% of these sADRs were not recorded as reported. Suspected adverse drug reactions that were not considered “expected” were recorded as reported more frequently than “expected” sADRs. However, clinical severity did not appear to impact on whether there was a record of reporting.

Clinical Significance

This is the first estimate of under reporting sADRs based on real world evidence from veterinary clinical records. The under-reporting rate implied by this study highlights that further interventions are required to improve reporting rate within the veterinary profession in order to support pharmacovigilance activities and improve drug safety.

目的:使用文本挖掘方法识别第一意见兽医自由文本临床叙述中记录的疑似药物不良反应实例,并评估这些实例是否也报告给了兽药管理局或相关营销部门:使用文本挖掘方法识别第一意见兽医自由文本临床叙述中记录的疑似药物不良反应实例,并评估这些实例是否也向兽药管理局或相关市场授权持有人报告,从而得出疑似药物不良反应(sADR)最低漏报率的估计值。描述可疑药物不良反应报告的特征,并探讨特定特征是否与报告提交相关:开发了两种正则表达式,用于识别小动物兽医监测网络数据库中电子健康记录的自由文本临床叙述中提及的 "药物不良反应 "和 "副作用"。对包含与所开发的正则表达式匹配的咨询内容进行人工审核,以确定是否纳入,并进一步分类以确定可疑产品、事件的严重性和预期性,以及是否已报告该事件。使用费雪精确检验法探讨了事件特征与报告之间的关联:共人工审核了 10,565 份记录,从中发现了 827 个 sADR。其中约 90% 的药物不良反应未被报告。与 "预期 "的 sADR 相比,"预期 "之外的疑似药物不良反应被报告的频率更高。然而,临床严重程度似乎并不影响是否有报告记录:临床意义:这是首次根据兽医临床记录中的实际证据对 sADR 报告不足的估计。临床意义:这是首次根据兽医临床记录中的实际证据估算出的药物不良反应报告率偏低的情况。本研究得出的药物不良反应报告率偏低的结论表明,需要采取进一步的干预措施来提高兽医行业的药物不良反应报告率,以支持药物警戒活动并提高药物安全性。
{"title":"Recording of suspected adverse drug reaction reporting in veterinary free-text clinical narratives","authors":"H. Davies,&nbsp;E. Blackwell,&nbsp;I. S. Fins,&nbsp;P. J. M. Noble,&nbsp;G. Pinchbeck,&nbsp;M. Pirmohamed,&nbsp;D. R. Killick","doi":"10.1111/jsap.13721","DOIUrl":"10.1111/jsap.13721","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To use text mining approaches to identify instances of suspected adverse drug reactions recorded in first opinion veterinary free-text clinical narratives, and to evaluate whether these were also reported to either the Veterinary Medicines Directorate or the relevant Marketing Authorisation holder in order to derive an estimate of the suspected adverse drug reaction (sADR) minimum under-reporting rate. To characterise sADR reports and explore whether particular features are associated with report submission.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two regular expressions were developed to identify mentions of “adverse drug reactions” and “side effects” in the free-text clinical narratives of electronic health records contained within the Small Animal Veterinary Surveillance Network database. Consultations containing a match for the developed regular expressions were manually reviewed for inclusion and further classified to determine the suspected product, seriousness and expectedness of the event, and an indication of whether the event had been reported. The associations between event characteristics and reporting were explored using Fisher's exact tests.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 10,565 records were manually reviewed from which 827 sADRs were identified. Approximately 90% of these sADRs were not recorded as reported. Suspected adverse drug reactions that were not considered “expected” were recorded as reported more frequently than “expected” sADRs. However, clinical severity did not appear to impact on whether there was a record of reporting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Clinical Significance</h3>\u0000 \u0000 <p>This is the first estimate of under reporting sADRs based on real world evidence from veterinary clinical records. The under-reporting rate implied by this study highlights that further interventions are required to improve reporting rate within the veterinary profession in order to support pharmacovigilance activities and improve drug safety.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17062,"journal":{"name":"Journal of Small Animal Practice","volume":"65 6","pages":"361-367"},"PeriodicalIF":1.6,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jsap.13721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140028304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control line failure in Angiostrongylus vasorum point-of-care serology test in dogs with angiostrongylosis due to suspected hook effect 疑似钩状效应导致血管瘤病犬血管瘤病毒点式血清学检测中的控制线失效。
IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-04 DOI: 10.1111/jsap.13716
E. N. Barker, J. R. Payne, H. Wilson

Objectives

Angiostrongylosis is a significant differential for a diverse range of clinical signs in dogs, many of whom present acutely and sometimes with fatal consequences. Point-of-care diagnostic assays include a commercially available Angiostrongylus vasorum qualitative direct lateral flow assay.

Materials and Methods

Case records from one referral centre from dogs with an invalid A. vasorum lateral flow assay, comprising an absent control line alongside a visible test line, were reviewed. As control line failure was hypothesised to be due to antigen excess; where available the A. vasorum lateral flow assay was repeated using dilutions of the original serum.

Results

Six dogs had an invalid A. vasorum lateral flow assay result. Five dogs had presented with acute-onset, severe clinical disease consistent with angiostrongylosis, and one dog was a clinically healthy in-contact. Clinical suspicion of angiostrongylosis was confirmed using alternative diagnostic testing and/or response to treatment. Repetition of the A. vasorum lateral flow assay, in four cases, using diluted plasma (10% to 12.5% v/v) resulted in the appearance of a control line alongside the visible test line.

Clinical Significance

A heavy burden of A. vasorum infection resulting in angiostrongylosis should be suspected in dogs with compatible clinical signs and an invalid A. vasorum lateral flow assay result due to control failure alongside a visible test line. Repetition of the test with a diluted serum may be considered to account for the hook effect, also known as the postzone phenomenon, as a possible cause.

目的:Angiostrongylosis 是一种重要的鉴别病,可导致犬出现多种临床症状,其中许多症状都是急性的,有时甚至会导致死亡。护理点诊断测定包括一种市场上可买到的血管分支杆菌定性直接侧流测定:对一家转诊中心的病例记录进行了审查,这些病例都是用无效的A. vasorum横向血流检测法检测的,其中对照线缺失,检测线可见。由于对照线失效被假定为抗原过量所致,因此在有条件的情况下,使用原始血清稀释液重复进行A. vasorum侧流试验:结果:六只狗的A. vasorum侧流检测结果无效。五只狗出现了与血管瘤病一致的急性严重临床疾病,一只狗是临床健康的接触者。通过其他诊断检测和/或对治疗的反应,临床怀疑的血管软骨病得到了证实。在四个病例中,使用稀释血浆(10% 至 12.5% v/v)重复进行血管虫侧流检测,结果在可见检测线旁出现了对照线:临床意义:对于临床症状相符,但因对照线与可见检测线同时出现而导致血管瘤病毒侧流检测结果无效的犬只,应怀疑血管瘤病毒感染导致血管瘤病。可以考虑用稀释的血清重复检测,以解释钩状效应(也称为后区现象)可能是造成这种情况的原因。
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引用次数: 0
Retrospective evaluation of leflunomide as an adjunctive therapy in dogs with non-associative immune-mediated thrombocytopenia: 20 cases (2008-2021) 来氟米特作为辅助疗法治疗非关联性免疫介导血小板减少症狗的回顾性评估:20 个病例(2008-2021 年)。
IF 1.6 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-03-03 DOI: 10.1111/jsap.13715
D. J. Spear, Z. J. Crouse, S. A. Kearns

Objective

To describe leflunomide as an adjunctive therapy in the treatment of non-associative immune-mediated thrombocytopenia.

Materials and Methods

A retrospective study of dogs with a diagnosis of non-associative immune-mediated thrombocytopenia treated with leflunomide March 2008 to September 2021 was conducted. Data collected included signalment, clinical signs, physical examination findings and diagnostic testing performed. Medications administered, duration of hospital stay, time to platelet concentration >150×109/L and adverse events during leflunomide therapy were recorded. Relapses within a year of diagnosis were reported.

Results

A total of 20 client-owned dogs met inclusion criteria. Nineteen of 20 dogs (95%) achieved a platelet concentration >150×109/L with leflunomide and prednisone combination therapy and four dogs (21.1%) relapsed during treatment or shortly after treatment. Adverse effects included diarrhoea (n=5), mild lymphopenia (n=9) and mild intermittent anaemia (n=1). A single dog developed hepatotoxicity presumed to be secondary to leflunomide therapy that resolved after drug discontinuation. One dog was treated for aspiration pneumonia during treatment. Two dogs were euthanased while receiving leflunomide.

Clinical Significance

Length of hospitalisation, time to platelet recovery, treatment response and relapse rate were comparable with alternative treatment protocols. Most adverse effects did not require leflunomide dose adjustment; however, two dogs died while undergoing leflunomide treatment and there is compelling evidence that one of these dogs experienced fatal infection secondary to immune-suppression. Hepatotoxicity remains a known complication of leflunomide treatment and serial biochemistry testing is recommended.

目的描述来氟米特作为治疗非关联性免疫介导的血小板减少症的辅助疗法:对2008年3月至2021年9月使用来氟米特治疗确诊为非关联性免疫介导的血小板减少症的犬只进行回顾性研究。收集的数据包括信号、临床症状、体格检查结果和进行的诊断测试。记录了来氟米特治疗期间的用药情况、住院时间、血小板浓度>150×109 /L的时间以及不良反应。报告了确诊后一年内的复发情况:共有 20 只客户饲养的狗符合纳入标准。20只狗中有19只(95%)在来氟米特和泼尼松联合治疗后血小板浓度达到150×109 /L以上,4只狗(21.1%)在治疗期间或治疗后不久复发。不良反应包括腹泻(5 只)、轻度淋巴细胞减少(9 只)和轻度间歇性贫血(1 只)。有一只狗出现了肝毒性,推测是继发于来氟米特治疗,停药后症状缓解。一只狗在治疗期间因吸入性肺炎接受了治疗。两只狗在接受来氟米特治疗期间被安乐死:住院时间、血小板恢复时间、治疗反应和复发率与其他治疗方案相当。大多数不良反应不需要调整来氟米特的剂量;但有两只狗在接受来氟米特治疗期间死亡,而且有确凿证据表明,其中一只狗因免疫抑制而继发致命感染。肝毒性仍然是来氟米特治疗的一种已知并发症,建议进行连续的生化检测。
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引用次数: 0
Combined cystourethroplasty and urethral sphincter occluder placement for treatment of urinary incontinence in a cat with genitourinary dysplasia 联合膀胱尿道成形术和尿道括约肌闭塞器植入术治疗生殖泌尿系统发育不良猫的尿失禁。
IF 1.7 2区 农林科学 Q2 VETERINARY SCIENCES Pub Date : 2024-02-29 DOI: 10.1111/jsap.13717
M. Gosling, J. Hall

A 10-month-old female neutered domestic shorthair cat presented with a history of urinary incontinence and recurrent bacterial cystitis since 2 months of age. Physical examination was unremarkable other than vulval hypoplasia. Genitourinary dysplasia was diagnosed following a physical examination, CT imaging and retrograde positive contrast urethrocystography. Attempted medical management of the urinary incontinence was unsuccessful. Surgical treatment consisted of cystourethroplasty combined with artificial urethral sphincter placement, resulting in marked improvement of urinary continence. Following multiple adjustments of the artificial urethral sphincter near-total continence was achieved, which was maintained at 10 months post-surgery.

一只 10 个月大的雌性绝育短毛猫自 2 个月大开始就出现尿失禁和反复细菌性膀胱炎。除外阴发育不良外,体格检查无其他异常。经过体格检查、CT 扫描和逆行阳性造影剂尿道膀胱造影检查,确诊为生殖泌尿系统发育不良。对尿失禁的药物治疗未获成功。手术治疗包括膀胱尿道成形术和人工尿道括约肌置入术,结果明显改善了患者的排尿功能。在对人工尿道括约肌进行多次调整后,患者的尿失禁症状几近完全消失,术后 10 个月仍未复发。
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引用次数: 0
期刊
Journal of Small Animal Practice
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