Journal of Small Animal Practice最新文献

A 4-month-old male intact domestic shorthair kitten was referred due to acute onset of severe respiratory distress. Aelurostrongylus abstrusus infection was diagnosed by Baermann technique. The kitten showed a fluctuating respiratory status despite anthelmintic and supportive therapy; severe initial distress followed by partial improvement, deterioration by Day 33 and marked recovery by Day 63. Monitoring included clinical examinations, oxygen saturation, faecal analysis, thoracic radiography and lung point-of-care ultrasound on Days 1, 10, 33 and 63. Lung ultrasound and thoracic radiographs consistently revealed diffusely distributed pulmonary disease and pleural involvement. Several pathological lung ultrasound features were identified, such as increased B-lines, subpleural nodules, lung consolidations with and without air-bronchograms, vascular sign and pleural line irregularity. This is the first report comparing lung ultrasound and thoracic radiography in a kitten with Aelurostrongylus abstrusus.

Objectives: To describe the electrophoretic pattern of proteinuria in dogs with naturally occurring Cushing's syndrome. We hypothesised that urine protein electrophoresis in dogs with spontaneous Cushing's syndrome will reveal glomerular proteinuria. We also hypothesised that the severity of proteinuria would decrease during treatment with trilostane.

Materials and methods: This prospective study included dogs with spontaneous Cushing's syndrome (n = 19) and healthy dogs (n = 10) serving as controls for urine protein electrophoresis. Urinary proteins were evaluated using sodium dodecyl sulphate agarose gel electrophoresis.

Results: Thirteen dogs with Cushing's syndrome had glomerular proteinuria, with high molecular weight bands between 66 and 150 kDa. Three dogs with Cushing's syndrome had mixed glomerular and tubular proteinuria, with low molecular weight bands between 14.3 and 26 kDa, in addition to high molecular weight bands. Three dogs with Cushing's syndrome had a physiological pattern of urine protein electrophoresis and these dogs were non-proteinuric. Seven dogs were re-evaluated 4 to 6 months after initiating treatment with trilostane. Before treatment, six dogs were proteinuric and one dog was non-proteinuric. After the treatment, three dogs were non-proteinuric and four dogs were proteinuric. Of these, proteinuria decreased in one dog (50%) and increased (up to 70%) in three dogs.

Clinical significance: Dogs with Cushing's syndrome predominantly exhibit glomerular proteinuria. No systematic improvement was observed during trilostane treatment.

We would like to comment on “High-dose induction therapy and treatment termination criteria for feline infectious peritonitis with remdesivir, GS-441524 and adjunctive mefloquine: 46 cases (2023) (Kamiyoshi et al., 2025).” A control group that completed 12 weeks of standard treatment was not included in this study, which makes it difficult to determine whether the shortened treatment regimen is as effective or superior to the traditional regimen. Additionally, only patients without neurological or ocular symptoms were screened, which limits the generalisability of the results to the feline infectious peritonitis (FIP) population as a whole. Nevertheless, this study offers a novel approach to stopping treatment for FIP using biochemical markers, such as acute-phase proteins and albumin/globulin ratio to determine the ideal duration of treatment.

Regarding data analysis, no explicit statistical comparisons were made, such as comparing the groups that stopped therapy before 12 weeks and those that finished 12 weeks of treatment, even though the report gives median treatment duration and survival rates. Additionally, the accuracy of the biochemical indicators in forecasting the effectiveness of medication termination was not examined using predictive analysis, such as the receiver operating characteristic curve. Utilising these analyses could greatly increase the suggested clinical decision-making approach’s dependability.

Analysing which acute-phase protein values have the biggest impact on the decision to stop therapy is one way to expand the conversation. Furthermore, what ought to be the clinical cut-off? Furthermore, it should be made clear whether the use of adjuvant medication, such as mefloquine, following the cessation of remdesivir/GS-441524 before 12 weeks serves as a preventative measure or as a remedy for treatment that is not yet complete. Another crucial query is whether the remdesivir and GS-441524 groups’ results differed in any way.

In order to guide future research, a randomised controlled trial should be carried out to compare a typical 12-week treatment with a strategy based on customised biochemical indicators. To build a more precise predictive model for treatment effectiveness in every instance, criteria utilising a variety of data, including globulin, SAA, haptoglobin, A/G ratio and clinical symptoms, should also be constructed. Additionally, long-term research should be done to track adverse effects and recurrence following therapy, particularly in cats with complicated neurological or ophthalmic problems.

H. Daungsupawong: Conceptualization; visualization; validation; writing – review and editing; writing – original draft. V. Wiwanitkit: Conceptualization; visualization; validation; supervision.

There is no funding.

The authors declare no conflict of interest.

The author uses a language editing computational tool in preparation of the article.

A 7-month-old entire male English springer spaniel presented with a two-month history of bilateral forelimb lameness, worse on the left side. Clinical examination revealed bilateral elbow discomfort. A computed tomography (CT) scan was performed (Siemens Somatom Go-Top, Siemens Healthineers, Erlangen, Germany), which revealed bilateral humeral intracondylar fissures, more severe on the left side (Fig 1A, B). Using fluoroscopic guidance, a minimally invasive approach was employed to place a 4.5 mm transcondylar locking screw (Arthrex GmbH, Munich, Germany) bilaterally (Fig 1E–H). The patient was discharged with a five-day course of meloxicam and instructions for crate rest and short leash walks (10 minutes, three times daily) for 6 weeks. At 6 weeks postoperatively, the dog was reassessed; no lameness or elbow discomfort was noted, and elbow manipulation was comfortable. A repeat CT scan, performed using an extended scale (metal dampening) protocol, demonstrated stable implants and progressive healing of the intracondylar fissures (Fig 1C, D). Recent publications have advocated proximal oblique osteotomies or the application of bone grafts/demineralised bone matrix with compression to promote healing of humeral intracondylar fissures. This case demonstrates that, with appropriate case selection, a well-placed positional screw can achieve healing without the need for additional interventions.

Alex Belch: Writing – review and editing, conceptualization, writing – original draft. Alexandros Bourbos: Conceptualization. Darren Carwardine: Conceptualization, review and editing.