Journal of Small Animal Practice最新文献_第8页

Intravesical urinary bladder duplication in a dog 一只狗的膀胱内重复。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-08-06 DOI: 10.1111/jsap.13769

M. J. R. Jacqmin, C. Baudin Tréhiou, A. Tortereau, P. Pillard

引用次数: 0

A rapid manual technique does not have adequate sensitivity and specificity to reliably discriminate between neutropenic and non-neutropenic dogs prior to administration of chemotherapy 快速人工技术不具备足够的灵敏度和特异性，无法在化疗前可靠地区分中性粒细胞减少和非中性粒细胞减少的狗。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-08-06 DOI: 10.1111/jsap.13773

M. Walton-Clark, T. Henriques, M. Best

Objectives

To develop and determine the accuracy of a rapid manual technique for the detection of pre-treatment neutropenia (<1.50 × 10⁹/L) in dogs receiving chemotherapy.

Materials and Methods

Twenty canine blood smears with known neutrophil counts between 1.00 × 10⁹/L and 3.00 × 10⁹/L were reviewed by two internal medicine clinicians and linear regressions performed to determine a cut-off value for a manual neutrophil count equating to >1.50 × 10⁹/L. Consecutive blood samples from dogs undergoing chemotherapy were processed through an automated haematology analyser (VetScan HM5, Abaxis), and prospective blinded manual review by the same two observers assessed whether the manual technique could accurately detect dogs with neutropenia.

Results

Linear regression analysis found a cut-off of >26 neutrophils per 10 low power fields at the monolayer to be equivalent to a neutrophil count of >1.5 × 10⁹/L. A total of 183 blood samples from 43 dogs were reviewed. Automated techniques detected neutropenia in 16 of 183 (9%) blood samples. Using the manual cut-off technique, 13 of 16 (81%) and 11 of 16 (69%) of neutropenic samples were correctly identified by observer 1 and observer 2, respectively. Twenty-three of 167 non-neutropenic dogs (14%) were incorrectly classified as neutropenic by observer 1, and 27 (16%) by observer 2. Inter-observer agreement was 92%. Sensitivity was 81% (95% confidence interval 54% to 96%) for observer 1 and 69% (95% confidence interval 41% to 89%) for observer 2. Specificity was 86% (95% confidence interval 80% to 91%) for observer 1 and 84% (95% confidence interval 77% to 89%) for observer 2.

Clinical Significance

Manual estimation resulted in up to five of 16 (31%) neutropenic samples being incorrectly classified. A full automated differential cell count remains preferable.

目的材料与方法：由两名内科临床医生对 20 份已知中性粒细胞计数在 1.00 × 109/L 和 3.00 × 109/L 之间的犬血液涂片进行审查，并进行线性回归，以确定中性粒细胞计数（9/L）的临界值：由两名内科临床医生对已知中性粒细胞计数在 1.00 × 109/L 和 3.00 × 109/L 之间的 20 份犬血液涂片进行复查，并进行线性回归，以确定人工中性粒细胞计数大于 1.50 × 109/L 的临界值。通过自动血液分析仪（VetScan HM5，Abaxis）处理接受化疗的犬的连续血液样本，并由同两名观察员进行前瞻性盲法人工审核，以评估人工技术是否能准确检测出患有中性粒细胞减少症的犬：线性回归分析发现，单层每 10 个低倍视野中嗜中性粒细胞数大于 26 个的临界值相当于嗜中性粒细胞数大于 1.5 × 109/L。共对 43 只狗的 183 份血液样本进行了审查。在 183 份血样中，有 16 份（9%）通过自动技术检测出中性粒细胞减少症。观察者 1 和观察者 2 使用手动截断技术分别正确识别了 16 份中性粒细胞减少样本中的 13 份（81%）和 11 份（69%）。在 167 只非中性粒细胞减少的狗中，有 23 只（14%）被观察者 1 错误地归类为中性粒细胞减少，27 只（16%）被观察者 2 错误地归类为中性粒细胞减少。观察者之间的一致性为 92%。观察者 1 的灵敏度为 81%（95% 置信区间为 54% 至 96%），观察者 2 的灵敏度为 69%（95% 置信区间为 41% 至 89%）。特异性方面，观察者 1 为 86%（95% 置信区间为 80%-91%），观察者 2 为 84%（95% 置信区间为 77%-89%）：人工估算导致 16 份中性粒细胞样本中有多达 5 份（31%）被错误分类。全自动差值细胞计数仍然更可取。

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引用次数: 0

Delayed post-traumatic alopecia of the dorso-lumbar area following a road accident in a cat without pelvic fracture 一只没有骨盆骨折的猫因交通事故导致腰背部延迟性创伤后脱发。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-08-06 DOI: 10.1111/jsap.13776

T. Burnouf, J. C. Husson, F. Degorce-Rubiales, A. Muller, E. Guaguere

An 11-month-old female, neutered domestic short-haired cat was presented for non-pruritic alopecia of the dorso-lumbar area which had appeared 1 month after a road accident. After the trauma, a fracture of the left hind limb was demonstrated without dermatological lesions on the dorso-lumbar area. One month later, hair loss was observed in this area. Four months later, clinical examination revealed dorso-lumbar alopecia. Histopathological findings included an absence of all adnexae, a mild fibroplasia and fibrosis without oriented collagen deposition, individual to coalescing pyogranulomas at the dermo-hypodermal junction and a moderately stenotic hypodermal artery. Clinical history, physical examination and histopathological findings were compatible with post-traumatic dorso-lumbar alopecia. Special features of this case include the location of the fracture and the more developed histopathological lesions with pyogranulomas at the dermo-hypodermal junction, the absence of hair follicles and a stenosing arteriopathy.

一只 11 个月大的雌性阉割短毛猫在一次交通事故后 1 个月出现腰背部非瘙痒性脱发。外伤发生后，左后肢骨折，但腰背部没有皮肤病变。一个月后，该部位出现脱发。四个月后，临床检查发现腰背部脱发。组织病理学检查结果包括：所有附件缺失，轻度纤维增生和纤维化，无定向胶原沉积，真皮-下真皮交界处有个别至凝聚性脓肿，下真皮动脉中度狭窄。临床病史、体格检查和组织病理学检查结果均与创伤后腰背部脱发相符。该病例的特点包括骨折位置、组织病理学病变更加发达，真皮与下真皮交界处出现脓肿、毛囊缺失和动脉狭窄病变。

引用次数: 0

Complications and putative risk factors for cecal or colonic surgery in dogs: 79 cases (2002-2015) 犬盲肠或结肠手术的并发症和潜在风险因素：79 例病例（2002-2015 年）。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-12 DOI: 10.1111/jsap.13763

J. C. James, S. O'Neill, G. E. Moore, K. M. Scotti, K. L. Perry, A. A. Sterman

Objectives

To evaluate the complication rate, mortality rate and putative risk factors for cecal or colonic surgery in dogs.

Materials and Methods

A multi-institutional retrospective study including dogs that had undergone surgery that involved the cecum or the colon. Medical records from three referral hospitals were reviewed for patient demographics and clinical data. The association between putative risk factors and survival to discharge or complications was assessed using univariable and multivariable analysis.

Results

Seventy-nine dogs met the criteria to be included in this study. Fifty-five dogs had full thickness incision surgeries, while 24 dogs had partial thickness surgeries. The complication and mortality rates for full thickness and partial thickness cecal/colonic surgeries were not statistically different. The dehiscence rate of colonic anastomosis in this study was four of 47 (8.5%). On univariate analysis, performing full thickness procedures out of hours had an association with increased complications and mortality. On multivariable analysis, no factors were associated with survival to discharge or complications. There was no association of board-certified surgeon presence in surgery with complications or mortality.

Clinical Significance

The performance of full thickness cecal/colonic surgery is not associated with a statistically significant increased risk for complications or mortality compared to partial thickness procedures, with a possible increased risk of complications and mortality in full thickness procedures out of hours.

目的：评估犬盲肠或结肠手术的并发症发生率、死亡率和潜在风险因素：评估犬盲肠或结肠手术的并发症发生率、死亡率和潜在风险因素：多机构回顾性研究，包括接受过盲肠或结肠手术的狗。研究人员查阅了三家转诊医院的病历，以了解患者的人口统计学特征和临床数据。采用单变量和多变量分析评估了推测的风险因素与出院存活率或并发症之间的关系：结果：79 只犬符合纳入本研究的标准。55只狗接受了全厚度切口手术，24只狗接受了部分厚度切口手术。全厚和部分厚盲肠/结肠手术的并发症发生率和死亡率没有统计学差异。在这项研究中，结肠吻合术的开裂率为 47 例中的 4 例（8.5%）。经单变量分析，在非工作时间进行全厚手术与并发症和死亡率增加有关。在多变量分析中，没有任何因素与出院存活率或并发症有关。有执照的外科医生参与手术与并发症和死亡率没有关系：临床意义：与部分厚度手术相比，全厚度盲肠/结肠手术的并发症或死亡率风险并没有统计学意义上的显著增加。

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引用次数: 0

Stapled functional end-to-end intestinal anastomosis with endovascular gastrointestinal anastomosis staplers in cats and small dogs 用血管内胃肠吻合订书机为猫和小狗进行功能性端对端肠吻合术。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-10 DOI: 10.1111/jsap.13756

S. Genoni, F. Cinti, M. Pilot, M. Rossanese, D. McCready, M. Cantatore

Objectives

To investigate the use of endovascular gastrointestinal stapling devices to perform intestinal functional end-to-end stapled anastomosis in small dogs and cats.

Materials and Methods

Medical records of dogs (≤10 kg) and cats that underwent intestinal resection and functional end-to-end stapled anastomosis with an endovascular gastrointestinal anastomosis (endovascular-GIA) stapling device at five small animal referral centres between April 2014 and September 2023 were retrospectively reviewed. Data including clinical findings, surgical technique, histopathology and complications were collected. A minimum follow-up of 10 days was required. Patients with follow-up of less than 10 days were included if they developed a major complication. Outcome was obtained from assessing the clinical records and contacting the referring veterinarians or owners. Estimated survival was generated according to the Kaplan–Meier method. Differences between survival curves were tested by log-rank test.

Results

Twenty-five patients (10 dogs and 15 cats) were included. The median bodyweight was 4.6 kg (range 2.6 to 10 kg). Nine patients were diagnosed with intestinal neoplasia, 16 with non-neoplastic intestinal disease. The median follow-up was 126 days (range 18 to 896 days). Five patients developed minor postoperative complications, including three superficial surgical site infections. No major postoperative complications were reported. Eighteen patients were alive at the end of the study, one patient was lost to follow-up. Kaplan–Meier estimated median survival time was not reached. Survival was significantly longer for patients with non-neoplastic versus neoplastic intestinal.

Clinical Significance

The study suggests that the use of endovascular gastrointestinal anastomosis staplers is safe and effective to perform intestinal functional end-to-end stapled anastomosis in dogs ≤10 kg and cats.

目的研究在小型犬和猫中使用血管内胃肠道缝合器进行肠道功能性端对端缝合吻合术的情况：回顾性审查了2014年4月至2023年9月期间在五个小动物转诊中心接受肠道切除术和使用血管内胃肠吻合术（endovascular-GIA）订书机装置进行功能性端端吻合术的犬（≤10千克）和猫的病历。收集的数据包括临床结果、手术技术、组织病理学和并发症。要求随访至少 10 天。随访时间少于 10 天的患者如果出现重大并发症，也会被纳入随访范围。结果通过评估临床记录和联系转诊兽医或主人获得。根据卡普兰-梅耶法得出估计存活率。生存曲线之间的差异通过对数秩检验进行检验：结果：共纳入 25 名患者（10 只狗和 15 只猫）。体重中位数为 4.6 千克（2.6 至 10 千克不等）。9名患者被诊断为肠道肿瘤，16名患者被诊断为非肿瘤性肠道疾病。随访时间中位数为 126 天（18 到 896 天不等）。五名患者出现了轻微的术后并发症，其中包括三次浅表手术部位感染。无重大术后并发症报告。研究结束时，有18名患者存活，1名患者失去随访机会。Kaplan-Meier估计的中位生存时间没有达到。非肿瘤性肠癌患者的存活时间明显长于肿瘤性肠癌患者：研究表明，使用血管内胃肠吻合订书机对体重≤10 千克的狗和猫进行肠道功能性端对端订书机吻合术是安全有效的。

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引用次数: 0

Intravenous fluid therapy compared to no treatment following blood donation in cats: a randomised controlled trial 猫献血后静脉输液治疗与不治疗的比较：随机对照试验。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-10 DOI: 10.1111/jsap.13760

M. Guedra Allais, K. Humm

Objectives

There is currently no consensus regarding the use of intravenous fluid therapy in feline patients post-blood donation in veterinary medicine. The primary aim of this study was to determine whether blood donation can be performed safely without post-donation intravenous fluid therapy. The secondary aim was to report owner-noted post-donation changes.

Materials and Methods

The study aimed to enrol 100 conscious feline blood donations by client-owned cats performed at a veterinary teaching hospital. Donors were randomised to either receive intravenous compound sodium lactate (twice the volume of blood donated over 2 hours) immediately after blood donation, or to receive no post-blood donation intravenous fluid therapy. Systolic blood pressure was measured non-invasively at 0, 60 and 120 minutes post-donation. Median blood pressures were compared between the two groups using a Shapiro-Wilk test. Owners were called the day following the donation to collect information on changes in their cat post-donation.

Results

One hundred cats were enrolled and the data of 97 cats were analysed; 46 who received intravenous fluid therapy and 51 who did not. Mean donation volume was 9.95 mL/kg for the intravenous fluid therapy group and 9.72 mL/kg for the non-intravenous fluid therapy group. At each time point, the median blood pressure did not differ significantly between the two groups. The main reported changes in both goups were bruising at the venepuncture site with 27.3% (12/44) in the IVFT group and 23.4% (9/37) in the no-IVFT group, and mild lethargy up to a maximum of 24 hours post donation with 11.4% (5/44) in the IVFT group and 18.9% (7/37) in the no-IVFT group.

Clinical Significance

This study suggests that the use of intravenous fluid therapy post-feline blood donation may not be necessary. This could mean reduced hospitalisation time for feline donors, possibly decreasing feline stress.

目的：目前，兽医学界尚未就猫科动物献血后使用静脉输液疗法达成共识。本研究的主要目的是确定献血是否可以在不进行献血后静脉输液治疗的情况下安全进行。次要目的是报告猫主人记录的献血后变化：这项研究的目的是在一家兽医教学医院招募 100 名有意识的猫科动物献血者。献血者被随机分配为献血后立即接受静脉注射复合乳酸钠（两倍于献血量，持续 2 小时），或献血后不接受静脉输液治疗。在献血后 0 分钟、60 分钟和 120 分钟分别对收缩压进行无创测量。采用 Shapiro-Wilk 检验比较两组的中位血压。在捐赠后的第二天给猫的主人打电话，收集猫在捐赠后的变化信息：对 100 只猫进行了登记，并分析了 97 只猫的数据；其中 46 只接受了静脉输液治疗，51 只没有。静脉输液治疗组的平均捐献量为 9.95 mL/kg，非静脉输液治疗组的平均捐献量为 9.72 mL/kg。在每个时间点，两组的血压中位数均无显著差异。两组报告的主要变化是静脉穿刺部位瘀伤，静脉输液治疗组为 27.3%（12/44），非静脉输液治疗组为 23.4%（9/37）；轻度嗜睡，静脉输液治疗组为 11.4%（5/44），非静脉输液治疗组为 18.9%（7/37），最长达捐献后 24 小时：本研究表明，猫科动物献血后可能无需使用静脉输液疗法。临床意义：该研究表明，猫科动物献血后可能不需要使用静脉输液疗法，这意味着猫科动物献血者的住院时间缩短，可能会减轻猫科动物的压力。

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引用次数: 0

Epidemiology of Angiostrongylus vasorum and Crenosoma vulpis infection in dogs in Denmark 丹麦犬只血管内 Angiostrongylus vasorum 和 Crenosoma vulpis 感染的流行病学。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-07 DOI: 10.1111/jsap.13762

K. Lundsgaard

Objectives

This retrospective study aimed to evaluate the risk factors (age and breed group) associated with Angiostrongylus vasorum and Crenosoma vulpis infection in dogs.

Materials and Methods

Faecal examinations obtained in dogs from January 2016 to December 2021 as part of routine clinical practice at two veterinary clinics in the Odsherred region of Zealand, Denmark, were included in this study. Faecal samples were analysed using the Baermann technique for nematode detection. Samples were collected from two clinics located in Northwestern Zealand, Denmark. Multinomial regression analysis, quasi-Poisson models and a generalised additive model for linearity were used to analyse the data.

Results

A total of 2,013 faecal samples were included in the study. Age was a significant risk factor for a positive Baermann, with a negative linear relationship observed (A. vasorum odds ratio: 0.80, 95% confidence interval: 0.70 to 0.91, C. vulpis odds ratio: 0.95, 95% confidence interval: 0.91 to 0.99, both nematodes: odds ratio: 0.87, 95% confidence interval: 0.77 to 0.99). Breed group analysis considering retrievers and flushing and water dog as reference group, demonstrated that sheep- and cattle dogs had a reduced risk of C. vulpis infection (odds ratio: 0.49, 95% confidence interval: 0.24 to 0.97), whereas dachshunds had an increased risk of A. vasorum infection (odds ratio: 3.28, 95% confidence interval: 1.14 to 9.47). Variations in the number of nematodes was found, with companion and toy dogs exhibiting higher numbers of C. vulpis (incidence rate ratio: 21.40, 95% confidence interval: 2.88 to 159) and sheep- and cattle dogs displaying higher numbers of A. vasorum (incidence rate ratio: 30.20, 95% confidence interval: 7.33 to 125). The prevalence rates of C. vulpis and A. vasorum were estimated at 14.50% (95% confidence interval: 13 to 16.10) and 3.40% (95% confidence interval: 2.70 to 4.30), respectively.

Clinical Significance

There are significant risk factors for nematode infection in dogs that can be considered for proper preventive care of this condition.

研究目的本项回顾性研究旨在评估与狗感染血管内 Angiostrongylus vasorum 和 Crenosoma vulpis 相关的风险因素（年龄和犬种）：本研究纳入了 2016 年 1 月至 2021 年 12 月期间在丹麦西兰岛奥德舍雷德地区两家兽医诊所进行的犬粪便检查，这是常规临床实践的一部分。粪便样本采用 Baermann 技术进行线虫检测分析。样本采集自位于丹麦西兰岛西北部的两家诊所。数据分析采用了多项式回归分析、准泊松模型和线性广义加法模型：研究共纳入了 2,013 份粪便样本。年龄是导致 Baermann 阳性的一个重要风险因素，且呈负线性关系（A. vasorum 的几率比：0.80，95% 置信区间：0.70 至 0.91；C. vulpis 的几率比：0.95，95% 置信区间：0.91 至 0.99；两种线虫的几率比：0.87，95% 置信区间：0.77 至 0.99）。犬种分组分析表明，牧羊犬和牧牛犬感染 C. vulpis 的风险较低（几率比：0.49，95% 置信区间：0.24 至 0.97），而腊肠犬感染 A. vasorum 的风险较高（几率比：3.28，95% 置信区间：1.14 至 9.47）。线虫的数量存在差异，伴侣犬和玩具犬感染 C. vulpis 的数量较多（发病率比：21.40，95% 置信区间：2.88 至 159），牧羊犬和牧牛犬感染 A. vasorum 的数量较多（发病率比：30.20，95% 置信区间：7.33 至 125）。据估计，C. vulpis 和 A. vasorum 的发病率分别为 14.50%（95% 置信区间：13 至 16.10）和 3.40%（95% 置信区间：2.70 至 4.30）：临床意义：狗感染线虫的风险因素很大，可考虑对这种疾病进行适当的预防护理。

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引用次数: 0

Diagnosis and surgical management of an extraskeletal osteosarcoma of the brachial plexus in a Belgian shepherd dog 比利时牧羊犬臂丛骨外骨肉瘤的诊断和手术治疗。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-04 DOI: 10.1111/jsap.13757

Z. R. Nalborczyk, E. Hall, R. Cappello, G. Polton, A. Groth

An 11-year-old Belgian shepherd presented with progressive right thoracic limb lameness. Computed tomography and magnetic resonance imaging revealed a brachial plexus neoplasm and cytology was suggestive of a sarcoma. The patient underwent forequarter amputation and hemilaminectomy of the fifth cervical to first thoracic vertebrae with nerve root transection. Histopathology confirmed extraskeletal osteosarcoma. Twelve months post-operatively, the dog was exercising normally, and computed tomography did not identify local recurrence or metastatic disease. This is the first recorded case of canine brachial plexus extraskeletal osteosarcoma.

一只 11 岁的比利时牧羊犬因右侧胸腔肢体进行性跛行而就诊。计算机断层扫描和磁共振成像检查发现了臂丛神经肿瘤，细胞学检查提示为肉瘤。患者接受了前肢截肢术和第五颈椎至第一胸椎的半椎板切除术，并进行了神经根切断术。组织病理学证实了骨外骨肉瘤。术后 12 个月，该犬运动正常，计算机断层扫描未发现局部复发或转移性疾病。这是记录在案的首例犬臂丛骨外骨肉瘤病例。

引用次数: 0

Partial anomalous pulmonary venous connection in a dog 一只狗的部分肺静脉连接异常。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-04 DOI: 10.1111/jsap.13761

K. Sugimoto, K. Arai, Y. Mochizuki, N. Akashi, R. Yoshitake, K. Kutara

引用次数: 0

Assessment of alendronate and dietary treatment in the management of feline idiopathic ionised hypercalcaemia and ionised hypercalcaemia associated with chronic kidney disease: 29 cases (2016-2022) 评估阿仑膦酸钠和饮食治疗在治疗猫特发性离子型高钙血症和与慢性肾病相关的离子型高钙血症中的应用：29例（2016-2022年）。

IF 1.7 2区农林科学 Q2 VETERINARY SCIENCES

Journal of Small Animal Practice

Pub Date : 2024-07-04 DOI: 10.1111/jsap.13755

U. Rzeszutek, F. Allerton, C. Au, I. Bras, A. Briggs, H. Broome, T. Gamston, S. Parton, J. Raj, G. M. Rossell, O. Russell, T. Sparks, J. Bazelle

Objectives

This retrospective cohort multicentre study aimed to characterise the signalment, clinicopathologic data, complications and the association between treatment and outcome (the reduction in ionised calcium concentration) in cats with idiopathic or chronic kidney disease-associated ionised hypercalcaemia managed with alendronate and standard treatment or standard treatment alone, and to compare the outcome between the two groups.

Materials and Methods

Medical records for cats diagnosed with idiopathic or chronic kidney disease-associated ionised hypercalcaemia were retrospectively reviewed. Cats treated with alendronate and standard treatment were assigned to the alendronate group and cats treated with standard treatment alone were assigned to the control group. The standard treatment was defined as dietary modification and/or monitoring of ionised calcium concentrations and management of complications secondary to hypercalcaemia. The follow-up period was selected as 6 months.

Results

Twenty-nine cats were enrolled in the study. Nine cats were included in the control group and 20 cats in the alendronate group. A significant reduction in serum ionised calcium was observed in both groups between the baseline and the follow-up visit; however, this reduction did not differ significantly between both groups (the mean change in the ionised calcium concentration in alendronate and control group was −0.18 and −0.17, respectively). Suspected bisphosphate-related osteonecrosis of the jaw was reported in one cat receiving alendronate.

Clinical Significance

In this study, similar reduction in serum ionised calcium concentration was observed in cats with ionised hypercalcaemia treated with diet alone and in cats treated with diet and alendronate. These results should be interpreted with caution, as the study was underpowered for meaningful statistical comparison. Cats receiving alendronate should be monitored for the development of adverse reactions, including osteonecrosis of the jaw.

研究目的这项回顾性队列多中心研究旨在描述特发性或慢性肾脏病相关离子型高钙血症猫咪的信号、临床病理数据、并发症以及治疗与结果（离子钙浓度的降低）之间的关联，并比较两组之间的结果：回顾性审查被诊断为特发性或慢性肾病相关离子化高钙血症的猫的病历。将接受阿仑膦酸钠和标准治疗的猫归入阿仑膦酸钠组，将只接受标准治疗的猫归入对照组。标准治疗的定义是调整饮食和/或监测离子钙浓度，并处理继发于高钙血症的并发症。随访期为 6 个月：结果：29 只猫参加了研究。结果：29 只猫参加了研究，其中 9 只为对照组，20 只为阿仑膦酸钠组。从基线到随访期间，两组的血清离子钙均有明显下降，但两组的下降幅度并无明显差异（阿仑膦酸钠组和对照组的离子钙浓度平均变化分别为-0.18和-0.17）。据报道，一只猫在接受阿仑膦酸钠治疗后出现了疑似与双磷酸盐相关的颌骨坏死：在这项研究中，单独使用饮食治疗离子型高钙血症的猫和使用饮食和阿仑膦酸钠治疗的猫的血清离子钙浓度降低情况相似。这些结果应谨慎解释，因为该研究的能力不足，无法进行有意义的统计比较。应监测接受阿仑膦酸钠治疗的猫是否出现不良反应，包括颌骨坏死。

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引用次数: 0