Pub Date : 2024-07-11DOI: 10.1016/j.jsamd.2024.100765
Young Jo Kim , Youngboo Moon , Jeong Hyun Moon , Hyoung Woo Kim , Wook Bahng , Hongsik Park , Young Jun Yoon , Jae Hwa Seo
In this study, we fabricated vertical Schottky barrier diodes (SBDs) based on wide bandgap semiconductor beta-phase gallium oxide (β-Ga2O3) and silicon carbide (SiC), respectively, and conducted proton irradiation experiments to analyze the radiation hardness of the SBDs comparatively. The effects of proton radiation on the performance of SBDs were assessed through measurements of forward current, capacitance, and breakdown characteristics. Both devices exhibited degradation in current and capacitance characteristics following proton irradiation, attributed to displacement damage (DD). Notably, the β-Ga2O3-based SBD demonstrated more pronounced deterioration compared to the SiC-based device despite similar vacancy distributions as confirmed by SRIM simulation. Moreover, a decrease in contact radius correlated with exacerbated degradation in the current characteristics of the β-Ga2O3-based SBD. Following proton irradiation, breakdown voltages of both devices increased due to elevated resistance induced by displacement damage. While both β-Ga2O3 and SiC-based SBDs experienced displacement damage under high fluence proton irradiation, the extent of performance degradation varied depending on the dimensions and quality of epitaxial and substrate layers.
{"title":"Displacement damage effect of proton irradiation on vertical β-Ga2O3 and SiC Schottky barrier diodes (SBDs)","authors":"Young Jo Kim , Youngboo Moon , Jeong Hyun Moon , Hyoung Woo Kim , Wook Bahng , Hongsik Park , Young Jun Yoon , Jae Hwa Seo","doi":"10.1016/j.jsamd.2024.100765","DOIUrl":"10.1016/j.jsamd.2024.100765","url":null,"abstract":"<div><p>In this study, we fabricated vertical Schottky barrier diodes (SBDs) based on wide bandgap semiconductor beta-phase gallium oxide (β<strong>-</strong>Ga<sub>2</sub>O<sub>3</sub>) and silicon carbide (SiC), respectively, and conducted proton irradiation experiments to analyze the radiation hardness of the SBDs comparatively. The effects of proton radiation on the performance of SBDs were assessed through measurements of forward current, capacitance, and breakdown characteristics. Both devices exhibited degradation in current and capacitance characteristics following proton irradiation, attributed to displacement damage (DD). Notably, the β<strong>-</strong>Ga<sub>2</sub>O<sub>3</sub>-based SBD demonstrated more pronounced deterioration compared to the SiC-based device despite similar vacancy distributions as confirmed by SRIM simulation. Moreover, a decrease in contact radius correlated with exacerbated degradation in the current characteristics of the β<strong>-</strong>Ga<sub>2</sub>O<sub>3</sub>-based SBD. Following proton irradiation, breakdown voltages of both devices increased due to elevated resistance induced by displacement damage. While both β<strong>-</strong>Ga<sub>2</sub>O<sub>3</sub> and SiC-based SBDs experienced displacement damage under high fluence proton irradiation, the extent of performance degradation varied depending on the dimensions and quality of epitaxial and substrate layers.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000960/pdfft?md5=f08c241591c3a07e5bd46d287a99b43f&pid=1-s2.0-S2468217924000960-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.1016/j.jsamd.2024.100763
Pradyumna Kumar Chand , Radha Raman , Zhi-Long Yen , Ian Daniell Santos , Wei-Ssu Liao , Ya-Ping Hsieh , Mario Hofmann
The advancement of future electronic devices necessitates dielectric materials with enhanced compositional complexity and improved capabilities. We here demonstrate a gas-phase alloying approach that yields ultrathin and crystalline dielectrics with attractive properties for the integration into electronics. A surface-selective deposition process was shown to produce sulfur (S) and selenium (Se) alloys with large-scale uniformity. Through combination of experimental diffraction analysis and materials modeling, we establish the crystallinity of the alloy with a modified lattice structure compared to the host materials. The resulting lattice arrangement endows the alloy dielectric with high ionic mobility as validated by electrochemical impedance spectroscopy. Leveraging this innovative feature, we fabricate memristive devices exhibiting promising performance characteristics. Our findings demonstrate the feasibility of utilizing gas-phase alloying to engineer dielectrics with superior properties and functionality for future device integration.
未来电子设备的发展需要成分更复杂、性能更强的电介质材料。我们在此展示了一种气相合金化方法,它能产生超薄、结晶的电介质,并具有极具吸引力的特性,可集成到电子设备中。研究表明,表面选择性沉积工艺可生产出具有大规模均匀性的硫 (S) 和硒 (Se) 合金。通过结合实验衍射分析和材料建模,我们确定了合金的结晶度,与主材料相比,合金的晶格结构有所改变。由此产生的晶格排列使合金电介质具有高离子迁移率,这一点已通过电化学阻抗光谱得到验证。利用这一创新特性,我们制造出了具有良好性能特点的忆阻器件。我们的研究结果证明了利用气相合金化技术制造具有优异性能和功能的电介质以实现未来器件集成的可行性。
{"title":"Gas phase alloyed crystalline S–Se dielectrics with high ionic mobility","authors":"Pradyumna Kumar Chand , Radha Raman , Zhi-Long Yen , Ian Daniell Santos , Wei-Ssu Liao , Ya-Ping Hsieh , Mario Hofmann","doi":"10.1016/j.jsamd.2024.100763","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100763","url":null,"abstract":"<div><p>The advancement of future electronic devices necessitates dielectric materials with enhanced compositional complexity and improved capabilities. We here demonstrate a gas-phase alloying approach that yields ultrathin and crystalline dielectrics with attractive properties for the integration into electronics. A surface-selective deposition process was shown to produce sulfur (S) and selenium (Se) alloys with large-scale uniformity. Through combination of experimental diffraction analysis and materials modeling, we establish the crystallinity of the alloy with a modified lattice structure compared to the host materials. The resulting lattice arrangement endows the alloy dielectric with high ionic mobility as validated by electrochemical impedance spectroscopy. Leveraging this innovative feature, we fabricate memristive devices exhibiting promising performance characteristics. Our findings demonstrate the feasibility of utilizing gas-phase alloying to engineer dielectrics with superior properties and functionality for future device integration.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000947/pdfft?md5=2e2390255e9e259672a7b80db97bfb4f&pid=1-s2.0-S2468217924000947-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.1016/j.jsamd.2024.100764
Yuan-Chang Liang, Chih-Chen Kuo
We successfully synthesized three-layered photocatalysts by modifying Bi nanoparticles on TiO2/BiVO4 bilayer composite films through a sol-gel process and sputtering. When exposed to ambient air, the surface of the prepared Bi nanoparticles oxidizes to form an amorphous ultra-thin Bi2O3 out layer. Under light exposure, this layer is reduced to metallic Bi, thanks to the band alignment between the Bi nanoparticles and TiO2/BiVO4 Z-scheme composite. The addition of Bi nanoparticles in the composite films improves visible-light absorption by the surface plasmon resonance (SPR), which contributes to the hot electron and enhances the photocatalytic characteristics. By constructing effective TiO2/BiVO4 Z-scheme heterostructures to facilitate photoinduced electron-hole pair separation and prevent recombination, Bi nanoparticles can efficiently capture photons and enhance the photocatalytic efficiency of semiconductors through the SPR effect. Optimizing the content of Bi nanoparticles decorated on the TiO2/BiVO4 Z-scheme composite film is a promising approach for designing a highly efficient photocatalyst, as evidenced by the performance of photoelectrochemical properties and RhB photodegradation ability.
我们通过溶胶-凝胶工艺和溅射法在 TiO2/BiVO4 双层复合膜上改性 Bi 纳米粒子,成功合成了三层光催化剂。当暴露在环境空气中时,制备的 Bi 纳米粒子表面会氧化形成无定形的超薄 Bi2O3 外层。在光照下,由于 Bi 纳米粒子和 TiO2/BiVO4 Z 型复合材料之间的带排列,该层被还原成金属 Bi。在复合薄膜中加入 Bi 纳米粒子可通过表面等离子体共振(SPR)改善可见光吸收,从而产生热电子并增强光催化特性。通过构建有效的 TiO2/BiVO4 Z 型异质结构来促进光诱导的电子-空穴对分离并防止重组,Bi 纳米粒子可以有效地捕获光子,并通过 SPR 效应提高半导体的光催化效率。从光电化学性质和 RhB 光降解能力的表现来看,优化装饰在 TiO2/BiVO4 Z 型复合薄膜上的 Bi 纳米粒子的含量是设计高效光催化剂的一种可行方法。
{"title":"Construction of broad-spectrum photocatalyst films through interface engineering: Orchestrating Bi nanoparticles in TiO2/BiVO4 Z-scheme heterojunctions","authors":"Yuan-Chang Liang, Chih-Chen Kuo","doi":"10.1016/j.jsamd.2024.100764","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100764","url":null,"abstract":"<div><p>We successfully synthesized three-layered photocatalysts by modifying Bi nanoparticles on TiO<sub>2</sub>/BiVO<sub>4</sub> bilayer composite films through a sol-gel process and sputtering. When exposed to ambient air, the surface of the prepared Bi nanoparticles oxidizes to form an amorphous ultra-thin Bi<sub>2</sub>O<sub>3</sub> out layer. Under light exposure, this layer is reduced to metallic Bi, thanks to the band alignment between the Bi nanoparticles and TiO<sub>2</sub>/BiVO<sub>4</sub> Z-scheme composite. The addition of Bi nanoparticles in the composite films improves visible-light absorption by the surface plasmon resonance (SPR), which contributes to the hot electron and enhances the photocatalytic characteristics. By constructing effective TiO<sub>2</sub>/BiVO<sub>4</sub> Z-scheme heterostructures to facilitate photoinduced electron-hole pair separation and prevent recombination, Bi nanoparticles can efficiently capture photons and enhance the photocatalytic efficiency of semiconductors through the SPR effect. Optimizing the content of Bi nanoparticles decorated on the TiO<sub>2</sub>/BiVO<sub>4</sub> Z-scheme composite film is a promising approach for designing a highly efficient photocatalyst, as evidenced by the performance of photoelectrochemical properties and RhB photodegradation ability.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000959/pdfft?md5=5d214488e862e1028e43ad2d8c623a45&pid=1-s2.0-S2468217924000959-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-02DOI: 10.1016/j.jsamd.2024.100762
Elena Stocco , Silvia Barbon , Ludovica Ceroni , Marta Confalonieri , Giada Pulzato , Samuel Pressi , Alice D'Osualdo , Marta Contran , Rafael Boscolo-Berto , Cesare Tiengo , Silvia Todros , Piero G. Pavan , Veronica Macchi , Raffaele De Caro , Laura Calvillo , Enzo Menna , Andrea Porzionato
Carbon nanotubes (CNT) are promising electroconductive nano-scale materials for neuroregeneration. Herein, we report on a new electroconductive composite scaffold made of the polymer 1% oxidized polyvinyl alcohol (OxPVA) combined with functionalized water soluble multiwalled CNT (OxPVA + MWCNT-S) (diazotization reaction). Preliminarily, MWCNT-S were characterized to evaluate the reaction outcome, the degree of functionalization and the dispersibility in water. Thereafter, OxPVA + MWCNT-S nanocomposite membranes were fabricated and analyzed for physicochemical properties (Raman spectroscopy, thermal decomposition, calorimetric properties, electroconductivity), macroscopic appearance and ultrastructure, mechanical behavior, in vitro cytotoxicity and in vivo biocompatibility. In parallel, OxPVA + MWCNT-S membranes with a linear pattern were also developed and analyzed for interaction with SH-SY5Y cells. Compared to OxPVA, the presence of MWCNT-S (only 0.016 wt%) significantly increased polymer conductivity and imparted a certain porosity without altering mechanical behaviour, as corroborated by uniaxial tensile tests. Neither cytotoxicity nor local signs of inflammation were detected in vitro and after subcutaneous implantation (14 and 42 days), proving composite material biocompatibility. OxPVA + MWCNT-S nanocomposite revealed as promising for future electroconductive conduits free from toxic effects amenable to CNT agglomeration within the polymer. Ideally, nerve lesions with wide gaps, may be effectively supported by those “active” devices, overcoming limitations of the available ones. Despite preliminary data, the presence of a linear pattern confirmed to have a beneficial effect over the scaffold/cells interaction.
{"title":"Partially oxidized polyvinyl alcohol + functionalized water soluble multiwalled carbon nanotubes: A new conductive nanocomposite material with promising implications for neuroregeneration","authors":"Elena Stocco , Silvia Barbon , Ludovica Ceroni , Marta Confalonieri , Giada Pulzato , Samuel Pressi , Alice D'Osualdo , Marta Contran , Rafael Boscolo-Berto , Cesare Tiengo , Silvia Todros , Piero G. Pavan , Veronica Macchi , Raffaele De Caro , Laura Calvillo , Enzo Menna , Andrea Porzionato","doi":"10.1016/j.jsamd.2024.100762","DOIUrl":"10.1016/j.jsamd.2024.100762","url":null,"abstract":"<div><p>Carbon nanotubes (CNT) are promising electroconductive nano-scale materials for neuroregeneration. Herein, we report on a new electroconductive composite scaffold made of the polymer 1% oxidized polyvinyl alcohol (OxPVA) combined with functionalized water soluble multiwalled CNT (OxPVA + MWCNT-S) (diazotization reaction). Preliminarily, MWCNT-S were characterized to evaluate the reaction outcome, the degree of functionalization and the dispersibility in water. Thereafter, OxPVA + MWCNT-S nanocomposite membranes were fabricated and analyzed for physicochemical properties (Raman spectroscopy, thermal decomposition, calorimetric properties, electroconductivity), macroscopic appearance and ultrastructure, mechanical behavior, <em>in vitro</em> cytotoxicity and <em>in vivo</em> biocompatibility. In parallel, OxPVA + MWCNT-S membranes with a linear pattern were also developed and analyzed for interaction with SH-SY5Y cells. Compared to OxPVA, the presence of MWCNT-S (only 0.016 wt%) significantly increased polymer conductivity and imparted a certain porosity without altering mechanical behaviour, as corroborated by uniaxial tensile tests. Neither cytotoxicity nor local signs of inflammation were detected <em>in vitro</em> and after subcutaneous implantation (14 and 42 days), proving composite material biocompatibility. OxPVA + MWCNT-S nanocomposite revealed as promising for future electroconductive conduits free from toxic effects amenable to CNT agglomeration within the polymer. Ideally, nerve lesions with wide gaps, may be effectively supported by those “active” devices, overcoming limitations of the available ones. Despite preliminary data, the presence of a linear pattern confirmed to have a beneficial effect over the scaffold/cells interaction.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000935/pdfft?md5=2199d2409ff7b8da052c7fe640acc250&pid=1-s2.0-S2468217924000935-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-27DOI: 10.1016/j.jsamd.2024.100760
Matteo Tonezzer , Michele Ricci , Nguyen X. Thai , Hugo Nguyen , Nguyen V. Duy , Nguyen D. Hoa
Recent urbanization and environmental problems urge for networks of sensors that can monitor air quality. Small, inexpensive, and smart sensors are one of the key components enabling the realization of such networks. Chemoresistive sensors are the ideal candidate, but they greatly lack selectivity, and for this reason, they are usually combined in arrays to create electronic noses, whose dimensions, however, make them not miniaturizable and cannot be integrated into portable devices. To overcome this inconvenience, we present a thermal electronic nose consisting of identical resistive sensors working at different temperatures so that the whole device is simple to make and tiny. The device contains two sensor arrays based on tin oxide nanowires decorated with Ag and Pt nanoparticles, respectively. The five sensors in each array are identical, but their response is differentiated by different temperatures locally generated by an on-chip integrated heater. This innovative approach allows the tiny array of five sensors together with the integrated heater to occupy only approximately 50 × 200 μm2 and consume only 120 μW. The tiny and portable device can estimate the concentration of H2 and NH3 in a mixture with a root mean square error of 6.1 ppm and 13.3 ppm, respectively, and it still works well after two months. The performance analysis of the double partial least squares regression used for concentration estimation also allows for feedback on which sensors are the most sensitive to which gas so that the electronic nose can be engineered for specific applications using the most suitable sensors. The size of the thermal electronic nose allows it to be integrated into portable and wearable devices, and its performance makes it suitable for any gas detection application. For example, a smartphone with an integrated sensor could carry out breath analysis and act as medical pre-screening or be used to evaluate the freshness of agri-food products in a rapid and non-invasive way.
{"title":"Micrometric thermal electronic nose able to detect and quantify individual gases in a mixture","authors":"Matteo Tonezzer , Michele Ricci , Nguyen X. Thai , Hugo Nguyen , Nguyen V. Duy , Nguyen D. Hoa","doi":"10.1016/j.jsamd.2024.100760","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100760","url":null,"abstract":"<div><p>Recent urbanization and environmental problems urge for networks of sensors that can monitor air quality. Small, inexpensive, and smart sensors are one of the key components enabling the realization of such networks. Chemoresistive sensors are the ideal candidate, but they greatly lack selectivity, and for this reason, they are usually combined in arrays to create electronic noses, whose dimensions, however, make them not miniaturizable and cannot be integrated into portable devices. To overcome this inconvenience, we present a thermal electronic nose consisting of identical resistive sensors working at different temperatures so that the whole device is simple to make and tiny. The device contains two sensor arrays based on tin oxide nanowires decorated with Ag and Pt nanoparticles, respectively. The five sensors in each array are identical, but their response is differentiated by different temperatures locally generated by an on-chip integrated heater. This innovative approach allows the tiny array of five sensors together with the integrated heater to occupy only approximately 50 × 200 μm<sup>2</sup> and consume only 120 μW. The tiny and portable device can estimate the concentration of H<sub>2</sub> and NH<sub>3</sub> in a mixture with a root mean square error of 6.1 ppm and 13.3 ppm, respectively, and it still works well after two months. The performance analysis of the double partial least squares regression used for concentration estimation also allows for feedback on which sensors are the most sensitive to which gas so that the electronic nose can be engineered for specific applications using the most suitable sensors. The size of the thermal electronic nose allows it to be integrated into portable and wearable devices, and its performance makes it suitable for any gas detection application. For example, a smartphone with an integrated sensor could carry out breath analysis and act as medical pre-screening or be used to evaluate the freshness of agri-food products in a rapid and non-invasive way.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000911/pdfft?md5=1dc070a65bdc12edc6a81917ef96cf82&pid=1-s2.0-S2468217924000911-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The annual prevalence of gastric cancer has increased in recent years. Curcumin (CUR) has shown great potential in the treatment of gastric cancer; however, its low bioavailability and poor efficacy hinder its widespread clinical application. Additionally, CUR has been found to be excellent photosensitizer in photodynamic therapy. In this study, the Fe-based metal-organic framework (MOF) Fe Tetrakis (4-carboxyphenyl) porphyrin (Fe-TCPP,FT) was used as a photosensitizer and mononuclear agent. The natural anti-tumor active ingredient CUR was loaded as both a chemotherapeutic agent and photosensitizer to form the nanoparticles CUR@FT (CF). Finally, a cell-penetrating peptide (CPP10) was modified on the surface of the nanoparticles to construct a drug delivery system (named CPP10-PEG@CUR@FT, CCF) that could actively target tumor cells while exerting a synergistic therapeutic effect of chemotherapy and photodynamic therapy. This can improve the efficacy of CUR as a chemotherapeutic drug or photosensitizer, and the high drug load and pH sensitivity of FT nanoparticles provide an excellent carrier for the efficient delivery of CUR. The polyethene glycol (PEG)-conjugated CPP10 (PEG-CPP10) coating allows nanoparticles to specifically target gastric cancer cells, significantly improving the absorption of nanoparticles in vivo and in vitro and improving biosafety. We evaluated the thermal stability, drug loading capacity, and safety of FT as a drug delivery vehicle. We also assessed the in vitro photodynamic performance and toxicity of various nanoparticles and the targeting and biocompatibility of CPP10-PEG@CUR@FT. CPP10-PEG@CUR@FT could specifically target tumor cells, and its effect on killing gastric cancer cells (MKN45) under light was much stronger than that of free CUR. Its toxicity and side effects to other organs and tissues are low, offering good biosafety. The experimental results showed that FT and CUR exerted synergistic effects on photodynamic therapy and chemotherapy. In summary, our novel CUR-loaded targeted nano drug delivery system offers significant advantages by combining photodynamic therapy and chemotherapy for tumor treatment. This approach introduces a new concept for integrating chemotherapy, photodynamic therapy and targeted drug delivery, potentially providing a new strategy for the clinical treatment of gastric cancer.
近年来,胃癌的发病率逐年上升。姜黄素(CUR)在治疗胃癌方面显示出巨大的潜力,但其生物利用度低、疗效差,阻碍了它在临床上的广泛应用。此外,在光动力疗法中,姜黄素被发现是一种出色的光敏剂。本研究采用铁基金属有机框架(MOF)铁四(4-羧基苯基)卟啉(Fe-TCPP,FT)作为光敏剂和单核剂。天然抗肿瘤活性成分 CUR 同时作为化疗剂和光敏剂被载入纳米粒子 CUR@FT (CF)。最后,在纳米颗粒表面修饰了一种细胞穿透肽(CPP10),构建了一种药物递送系统(CPP10-PEG@CUR@FT,CCF),该系统可以主动靶向肿瘤细胞,同时发挥化疗和光动力疗法的协同治疗作用。FT纳米颗粒的高载药量和pH敏感性为CUR的高效递送提供了良好的载体。聚乙二醇(PEG)共轭 CPP10(PEG-CPP10)涂层可使纳米颗粒特异性地靶向胃癌细胞,显著改善纳米颗粒在体内和体外的吸收,提高生物安全性。我们评估了 FT 作为给药载体的热稳定性、载药能力和安全性。我们还评估了各种纳米颗粒的体外光动力性能和毒性,以及 CPP10-PEG@CUR@FT 的靶向性和生物相容性。结果表明,CPP10-PEG@CUR@FT可特异性靶向肿瘤细胞,在光照下对胃癌细胞(MKN45)的杀伤作用远强于游离CUR。其对其他器官和组织的毒性和副作用较低,具有良好的生物安全性。实验结果表明,FT 和 CUR 在光动力治疗和化疗中具有协同作用。总之,我们的新型 CUR 靶向纳米给药系统将光动力疗法和化疗结合起来治疗肿瘤,具有显著的优势。这种方法引入了化疗、光动力疗法和靶向给药相结合的新概念,有可能为胃癌的临床治疗提供一种新策略。
{"title":"CPP10-targeted photoactivatable MOF nanosystem for combined photodynamic Therapy−Chemotherapy of cancer","authors":"Jiahui Kong, Mengru Cai, Rongyue Zhu, Yongqiang Zhang, Yuji Du, Xiaohong Jing, Yufei Sun, Rongrong Chang, Changhai Qu, Xiaoxv Dong, Jian Ni, Xingbin Yin","doi":"10.1016/j.jsamd.2024.100761","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100761","url":null,"abstract":"<div><p>The annual prevalence of gastric cancer has increased in recent years. Curcumin (CUR) has shown great potential in the treatment of gastric cancer; however, its low bioavailability and poor efficacy hinder its widespread clinical application. Additionally, CUR has been found to be excellent photosensitizer in photodynamic therapy. In this study, the Fe-based metal-organic framework (MOF) Fe Tetrakis (4-carboxyphenyl) porphyrin (Fe-TCPP,FT) was used as a photosensitizer and mononuclear agent. The natural anti-tumor active ingredient CUR was loaded as both a chemotherapeutic agent and photosensitizer to form the nanoparticles CUR@FT (CF). Finally, a cell-penetrating peptide (CPP10) was modified on the surface of the nanoparticles to construct a drug delivery system (named CPP10-PEG@CUR@FT, CCF) that could actively target tumor cells while exerting a synergistic therapeutic effect of chemotherapy and photodynamic therapy. This can improve the efficacy of CUR as a chemotherapeutic drug or photosensitizer, and the high drug load and pH sensitivity of FT nanoparticles provide an excellent carrier for the efficient delivery of CUR. The polyethene glycol (PEG)-conjugated CPP10 (PEG-CPP10) coating allows nanoparticles to specifically target gastric cancer cells, significantly improving the absorption of nanoparticles in vivo and in vitro and improving biosafety. We evaluated the thermal stability, drug loading capacity, and safety of FT as a drug delivery vehicle. We also assessed the in vitro photodynamic performance and toxicity of various nanoparticles and the targeting and biocompatibility of CPP10-PEG@CUR@FT. CPP10-PEG@CUR@FT could specifically target tumor cells, and its effect on killing gastric cancer cells (MKN45) under light was much stronger than that of free CUR. Its toxicity and side effects to other organs and tissues are low, offering good biosafety. The experimental results showed that FT and CUR exerted synergistic effects on photodynamic therapy and chemotherapy. In summary, our novel CUR-loaded targeted nano drug delivery system offers significant advantages by combining photodynamic therapy and chemotherapy for tumor treatment. This approach introduces a new concept for integrating chemotherapy, photodynamic therapy and targeted drug delivery, potentially providing a new strategy for the clinical treatment of gastric cancer.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000923/pdfft?md5=5270e2b1be4d104451eb0ca533fc1b29&pid=1-s2.0-S2468217924000923-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-24DOI: 10.1016/j.jsamd.2024.100759
Lin Wang , Lei Qiao , Yuzhi Liu , Fengyue Li , Attalla F. El-kott , Mohammed A. AlShehri , Kareem Morsy
The current investigation aims to study the bio route preparation of chitosan capped-silver nanoparticles using aqueous flower extract of the Achillea ptarmica plant. The biosynthesized silver nanoparticles/chitosan (Ag NPs@CHI) were characterized by various spectroscopic techniques. The creation of Ag nanoparticles over the chitosan was initially determined by the presence of a single broad peak at 545 nm that was recorded by the UV–Vis spectrum. The presence of poly-dispersity, spherical shape and nanosizes in the Ag NPs@CHI were verified by the TEM and SEM pictures. The purity and crystalline nature of the prepared Ag NPs@CHI were confirmed by XRD analysis. In vivo, Ag NPs@CHI decreased the inflammatory cells presence in the colon and ileum, lowered the levels of IL-17A, IL-1β, IL-6, and TNF-α, raised the levels of IL-10 and IL-4 in colon tissues, enhanced acetate and propionate production. The findings revealed that Ag NPs@CHI have the potential to boost intestinal structure restoration, decrease levels of inflammatory cytokines and enhance short-chain fatty acid (SCFA) levels. Our research demonstrated that Ag NPs@CHI can safeguard the intestinal barrier by upregulating the expression of Claudin-1 and Occludin. Furthermore, silver nanoparticles suppressed the MAPK signaling pathway to ameliorate the inflammatory condition. Following the completion of clinical trials, these novel nanoparticles could serve as a promising new treatment for diarrhea in humans.
目前的研究旨在利用蓍草花的水提取物,通过生物途径制备壳聚糖封端银纳米粒子。通过各种光谱技术对生物合成的银纳米粒子/壳聚糖(Ag NPs@CHI)进行了表征。通过紫外可见光谱记录的 545 纳米波长处的单个宽峰,初步确定了壳聚糖上银纳米粒子的形成。通过 TEM 和 SEM 照片验证了 Ag NPs@CHI 的多分散性、球形和纳米尺寸。XRD 分析证实了制备的 Ag NPs@CHI 的纯度和结晶性质。在体内,Ag NPs@CHI 减少了结肠和回肠中炎症细胞的存在,降低了 IL-17A、IL-1β、IL-6 和 TNF-α 的水平,提高了结肠组织中 IL-10 和 IL-4 的水平,促进了乙酸盐和丙酸盐的产生。研究结果表明,Ag NPs@CHI具有促进肠道结构恢复、降低炎性细胞因子水平和提高短链脂肪酸(SCFA)水平的潜力。我们的研究表明,银纳米粒子@CHI可通过上调Claudin-1和Occludin的表达来保护肠道屏障。此外,银纳米粒子还能抑制 MAPK 信号通路,从而改善炎症状况。在完成临床试验后,这些新型纳米粒子有望成为治疗人类腹泻的新疗法。
{"title":"Ultrasound assisted green synthesis of silver nanoparticles stabilized by chitosan polymers: Investigation of its therapeutic application in diarrhea","authors":"Lin Wang , Lei Qiao , Yuzhi Liu , Fengyue Li , Attalla F. El-kott , Mohammed A. AlShehri , Kareem Morsy","doi":"10.1016/j.jsamd.2024.100759","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100759","url":null,"abstract":"<div><p>The current investigation aims to study the bio route preparation of chitosan capped-silver nanoparticles using aqueous flower extract of the <em>Achillea ptarmica</em> plant. The biosynthesized silver nanoparticles/chitosan (Ag NPs@CHI) were characterized by various spectroscopic techniques. The creation of Ag nanoparticles over the chitosan was initially determined by the presence of a single broad peak at 545 nm that was recorded by the UV–Vis spectrum. The presence of poly-dispersity, spherical shape and nanosizes in the Ag NPs@CHI were verified by the TEM and SEM pictures. The purity and crystalline nature of the prepared Ag NPs@CHI were confirmed by XRD analysis. <em>In vivo</em>, Ag NPs@CHI decreased the inflammatory cells presence in the colon and ileum, lowered the levels of IL-17A, IL-1β, IL-6, and TNF-α, raised the levels of IL-10 and IL-4 in colon tissues, enhanced acetate and propionate production. The findings revealed that Ag NPs@CHI have the potential to boost intestinal structure restoration, decrease levels of inflammatory cytokines and enhance short-chain fatty acid (SCFA) levels. Our research demonstrated that Ag NPs@CHI can safeguard the intestinal barrier by upregulating the expression of Claudin-1 and Occludin. Furthermore, silver nanoparticles suppressed the MAPK signaling pathway to ameliorate the inflammatory condition. Following the completion of clinical trials, these novel nanoparticles could serve as a promising new treatment for diarrhea in humans.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S246821792400090X/pdfft?md5=e19e0390d66f04094da6eca0a255b71a&pid=1-s2.0-S246821792400090X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-16DOI: 10.1016/j.jsamd.2024.100758
Tran Thi Viet Nga , Nguyen Thi Lan , To Thanh Loan , Tran Quang Dat
In this work, graphene oxide (GO) was prepared via the Hummers’ method, whereas SrFe12O19, SrFe12O19@Fe3O4, and SrFe12O19@Fe3O4@rGO were fabricated using the hydrothermal techniques. The samples' phase structure, surface morphology, magnetic properties, and electromagnetic wave absorption characteristics were studied and compared. Findings show that the Fe3O4 particles adhered to the surface of the SrFe12O19 hexagonal plates, and the combination of SrFe12O19@Fe3O4 foam flakes and two-dimensional graphene rGO could enhance the absorption electromagnetic wave performance. The composite SrFe12O19@Fe3O4@rGO sample exhibited an ideal impedance matching within the frequency f range of 11 GHz–12.4 GHz. The minimum reflection loss reached −62.3 dB at 12.2 GHz with a thickness of 2 mm. With a thickness of 2 mm, the effective absorption bandwidth obtained the value of −20 dB, covering a range of 9.3 GHz. The composite SrFe12O19@Fe3O4@rGO sample, which shows the highest performance both in reflectivity and bandwidth, can find potential application in microwave absorptions.
{"title":"Enhancement of the microwave absorption properties of the SrFe12O19@Fe3O4@rGO composite material","authors":"Tran Thi Viet Nga , Nguyen Thi Lan , To Thanh Loan , Tran Quang Dat","doi":"10.1016/j.jsamd.2024.100758","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100758","url":null,"abstract":"<div><p>In this work, graphene oxide (GO) was prepared via the Hummers’ method, whereas SrFe<sub>12</sub>O<sub>19</sub>, SrFe<sub>12</sub>O<sub>19</sub>@Fe<sub>3</sub>O<sub>4</sub>, and SrFe<sub>12</sub>O<sub>19</sub>@Fe<sub>3</sub>O<sub>4</sub>@rGO were fabricated using the hydrothermal techniques. The samples' phase structure, surface morphology, magnetic properties, and electromagnetic wave absorption characteristics were studied and compared. Findings show that the Fe<sub>3</sub>O<sub>4</sub> particles adhered to the surface of the SrFe<sub>12</sub>O<sub>19</sub> hexagonal plates, and the combination of SrFe<sub>12</sub>O<sub>19</sub>@Fe<sub>3</sub>O<sub>4</sub> foam flakes and two-dimensional graphene rGO could enhance the absorption electromagnetic wave performance. The composite SrFe<sub>12</sub>O<sub>19</sub>@Fe<sub>3</sub>O<sub>4</sub>@rGO sample exhibited an ideal impedance matching within the frequency <em>f</em> range of 11 GHz–12.4 GHz. The minimum reflection loss reached −62.3 dB at 12.2 GHz with a thickness of 2 mm. With a thickness of 2 mm, the effective absorption bandwidth obtained the value of −20 dB, covering a range of 9.3 GHz. The composite SrFe<sub>12</sub>O<sub>19</sub>@Fe<sub>3</sub>O<sub>4</sub>@rGO sample, which shows the highest performance both in reflectivity and bandwidth, can find potential application in microwave absorptions.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000893/pdfft?md5=9721a26c61f0f94c1bab48ffca17ccf3&pid=1-s2.0-S2468217924000893-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-08DOI: 10.1016/j.jsamd.2024.100757
Cui Jin , Zhongxin Zhang , Xiaopei Li
The impact of the nanoparticles on the dyspepsia mice gut microbiota is evaluated through the utilization of the 16S rRNA technique. Various methods were employed to characterize the NPs. In the textile, culinary, paper, leather, and printing sectors, synthetic dyes are frequently employed as coloring agents. Because these dye molecules are harmful to both the environment and living things, it is difficult to remove them sustainably. Here, we have produced nanoparticles embedded in chitosan-polyvinyl alcohol hydrogel (CS-PVA) by using bark's Pistacia under ultrasonic irradiation. The reduction of Ag + ions into Ag0 NPs was detected by a visual change in the colors. UV–Vis analysis indicated that the characteristic SPR band appeared near ∼440–450 nm. UV/Vis, EDX-elemental mapping, SEM, TEM, ICP-OES, and XRD analysis were applied to characterize the Ag NPs/CS-PVA nanocomposite. The recent study focused on the cellular and molecular aspects. The MTT assay was conducted for 48 h to evaluate the anti-human gastric cancer and cytotoxicity efficacies of the treated cells with nanocomposite. The assessment was performed on normal (HUVEC) and gastric cancer cells, namely MKN45 and NCI–N87. The IC50 values of nanocomposite against MKN45 and NCI–N87 were 180 and 151 μg/mL, respectively. The dose-dependent reduction in malignant gastric cell viability was observed in the nanocomposite presence. Furthermore, the nanocomposite induced cell apoptosis by 40–50%, leading to an increase in the expression of pro-apoptotic markers (Bax and cleaved caspase-8) and a decrease in the expression of the anti-apoptotic marker, Bcl-2. Furthermore, the nanocomposite showed inhibitory effects on colony formation. Our results indicate that the nanocomposite can increase p53 expression and decrease the expression of STAT3 in treated cells. This indicates that p53 and STAT3 play crucial roles in the biological effects induced by the extract in human gastric carcinoma cells. The data from the gut microbiome suggested that nanocomposites have the ability to control the rebalancing of homeostasis and microbiome composition by decreasing the levels of harmful bacteria, and at the same time, increasing the levels of beneficial bacteria. Following the introduction of nanocomposite, there was an observed rise in the levels of gastrointestinal hormones in the serum, including gastrin and motilin, while the levels of vasoactive intestinal peptide decreased. The application of nanocomposite led to an improvement in gastrointestinal movement, encompassing a rise in the rate of transit through the small intestine and the rate of gastric emptying. These findings offer that the Ag NPs/CS-PVA nanocomposite could be a promising anticancer treatment for functional dyspepsia and gastric cancer.
{"title":"Silver nanoparticles stabilized by chitosan-polyvinyl alcohol polymers mediated by Pistacia extract for treatment of functional dyspepsia and gastric cancer","authors":"Cui Jin , Zhongxin Zhang , Xiaopei Li","doi":"10.1016/j.jsamd.2024.100757","DOIUrl":"10.1016/j.jsamd.2024.100757","url":null,"abstract":"<div><p>The impact of the nanoparticles on the dyspepsia mice gut microbiota is evaluated through the utilization of the 16S rRNA technique. Various methods were employed to characterize the NPs. In the textile, culinary, paper, leather, and printing sectors, synthetic dyes are frequently employed as coloring agents. Because these dye molecules are harmful to both the environment and living things, it is difficult to remove them sustainably. Here, we have produced nanoparticles embedded in chitosan-polyvinyl alcohol hydrogel (CS-PVA) by using bark's <em>Pistacia</em> under ultrasonic irradiation. The reduction of Ag <sup>+</sup> ions into Ag<sup>0</sup> NPs was detected by a visual change in the colors. UV–Vis analysis indicated that the characteristic SPR band appeared near ∼440–450 nm. UV/Vis, EDX-elemental mapping, SEM, TEM, ICP-OES, and XRD analysis were applied to characterize the Ag NPs/CS-PVA nanocomposite. The recent study focused on the cellular and molecular aspects. The MTT assay was conducted for 48 h to evaluate the anti-human gastric cancer and cytotoxicity efficacies of the treated cells with nanocomposite. The assessment was performed on normal (HUVEC) and gastric cancer cells, namely MKN45 and NCI–N87. The IC<sub>50</sub> values of nanocomposite against MKN45 and NCI–N87 were 180 and 151 μg/mL, respectively. The dose-dependent reduction in malignant gastric cell viability was observed in the nanocomposite presence. Furthermore, the nanocomposite induced cell apoptosis by 40–50%, leading to an increase in the expression of pro-apoptotic markers (Bax and cleaved caspase-8) and a decrease in the expression of the anti-apoptotic marker, Bcl-2. Furthermore, the nanocomposite showed inhibitory effects on colony formation. Our results indicate that the nanocomposite can increase p53 expression and decrease the expression of STAT3 in treated cells. This indicates that p53 and STAT3 play crucial roles in the biological effects induced by the extract in human gastric carcinoma cells. The data from the gut microbiome suggested that nanocomposites have the ability to control the rebalancing of homeostasis and microbiome composition by decreasing the levels of harmful bacteria, and at the same time, increasing the levels of beneficial bacteria. Following the introduction of nanocomposite, there was an observed rise in the levels of gastrointestinal hormones in the serum, including gastrin and motilin, while the levels of vasoactive intestinal peptide decreased. The application of nanocomposite led to an improvement in gastrointestinal movement, encompassing a rise in the rate of transit through the small intestine and the rate of gastric emptying. These findings offer that the Ag NPs/CS-PVA nanocomposite could be a promising anticancer treatment for functional dyspepsia and gastric cancer.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":6.7,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000881/pdfft?md5=537d74af50bbd63b42139b5301429750&pid=1-s2.0-S2468217924000881-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141415104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-04DOI: 10.1016/j.jsamd.2024.100754
Miso Kim, Sehee Kim, Bonggeun Shong
Dimethylaluminum isopropoxide (DMAI) is attracting attention as an alternative precursor for atomic layer deposition (ALD) of aluminum oxide (Al2O3). However, the surface chemical reaction mechanisms of DMAI during ALD regarding its dimeric structure under vacuum deposition process conditions has yet to be clear. In this work, the adsorption mechanism of dimeric and monomeric DMAI on a fully hydroxylated Al2O3 surface is studied using machine-learning potential (MLP) calculations. The initial adsorption of DMAI appears facile and would result in the coexistence of both methyl and isopropoxy ligands on the surface. The reactivity of DMAI is smaller than that of TMA, owing to the propensity of DMAI to adopt a dimeric form. Especially when the substrate is partially covered by other adsorbate species, the large molecular size and low reactivity of dimeric DMAI considerably hinder its reactivity toward surface adsorption. Current results are in good correspondence with the previous experimental results, where lower growth per cycle (GPC) and higher selectivity in area-selective ALD (AS-ALD) could be observed by using DMAI than compared to those of TMA processes.
{"title":"Adsorption of dimethylaluminum isopropoxide (DMAI) on the Al2O3 surface: A machine-learning potential study","authors":"Miso Kim, Sehee Kim, Bonggeun Shong","doi":"10.1016/j.jsamd.2024.100754","DOIUrl":"10.1016/j.jsamd.2024.100754","url":null,"abstract":"<div><p>Dimethylaluminum isopropoxide (DMAI) is attracting attention as an alternative precursor for atomic layer deposition (ALD) of aluminum oxide (Al<sub>2</sub>O<sub>3</sub>). However, the surface chemical reaction mechanisms of DMAI during ALD regarding its dimeric structure under vacuum deposition process conditions has yet to be clear. In this work, the adsorption mechanism of dimeric and monomeric DMAI on a fully hydroxylated Al<sub>2</sub>O<sub>3</sub> surface is studied using machine-learning potential (MLP) calculations. The initial adsorption of DMAI appears facile and would result in the coexistence of both methyl and isopropoxy ligands on the surface. The reactivity of DMAI is smaller than that of TMA, owing to the propensity of DMAI to adopt a dimeric form. Especially when the substrate is partially covered by other adsorbate species, the large molecular size and low reactivity of dimeric DMAI considerably hinder its reactivity toward surface adsorption. Current results are in good correspondence with the previous experimental results, where lower growth per cycle (GPC) and higher selectivity in area-selective ALD (AS-ALD) could be observed by using DMAI than compared to those of TMA processes.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":null,"pages":null},"PeriodicalIF":8.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000856/pdfft?md5=9cbdef6a50b4b9595b5b7045893dbb76&pid=1-s2.0-S2468217924000856-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141276431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}