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Displacement damage effect of proton irradiation on vertical β-Ga2O3 and SiC Schottky barrier diodes (SBDs) 质子辐照对垂直 β-Ga2O3 和 SiC 肖特基势垒二极管 (SBD) 的位移损伤效应
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-11 DOI: 10.1016/j.jsamd.2024.100765
Young Jo Kim , Youngboo Moon , Jeong Hyun Moon , Hyoung Woo Kim , Wook Bahng , Hongsik Park , Young Jun Yoon , Jae Hwa Seo

In this study, we fabricated vertical Schottky barrier diodes (SBDs) based on wide bandgap semiconductor beta-phase gallium oxide (β-Ga2O3) and silicon carbide (SiC), respectively, and conducted proton irradiation experiments to analyze the radiation hardness of the SBDs comparatively. The effects of proton radiation on the performance of SBDs were assessed through measurements of forward current, capacitance, and breakdown characteristics. Both devices exhibited degradation in current and capacitance characteristics following proton irradiation, attributed to displacement damage (DD). Notably, the β-Ga2O3-based SBD demonstrated more pronounced deterioration compared to the SiC-based device despite similar vacancy distributions as confirmed by SRIM simulation. Moreover, a decrease in contact radius correlated with exacerbated degradation in the current characteristics of the β-Ga2O3-based SBD. Following proton irradiation, breakdown voltages of both devices increased due to elevated resistance induced by displacement damage. While both β-Ga2O3 and SiC-based SBDs experienced displacement damage under high fluence proton irradiation, the extent of performance degradation varied depending on the dimensions and quality of epitaxial and substrate layers.

在这项研究中,我们分别基于宽带隙半导体β相氧化镓(β-Ga2O3)和碳化硅(SiC)制作了垂直肖特基势垒二极管(SBD),并进行了质子辐照实验,以比较分析 SBD 的辐照硬度。通过测量正向电流、电容和击穿特性,评估了质子辐照对 SBD 性能的影响。质子辐照后,两种器件的电流和电容特性都出现了衰减,这归因于位移损伤(DD)。值得注意的是,与基于碳化硅的器件相比,基于 β-Ga2O3 的 SBD 表现出更明显的劣化,尽管 SRIM 模拟证实了相似的空位分布。此外,接触半径的减小与基于 β-Ga2O3 的 SBD 的电流特性劣化加剧相关。质子辐照后,由于位移损伤导致电阻升高,两种器件的击穿电压都增加了。虽然在高通量质子辐照下,β-Ga2O3 和基于碳化硅的 SBD 都会出现位移损伤,但性能退化的程度因外延层和衬底层的尺寸和质量而异。
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引用次数: 0
Gas phase alloyed crystalline S–Se dielectrics with high ionic mobility 具有高离子迁移率的气相合金晶体 S-Se 介电材料
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-02 DOI: 10.1016/j.jsamd.2024.100763
Pradyumna Kumar Chand , Radha Raman , Zhi-Long Yen , Ian Daniell Santos , Wei-Ssu Liao , Ya-Ping Hsieh , Mario Hofmann

The advancement of future electronic devices necessitates dielectric materials with enhanced compositional complexity and improved capabilities. We here demonstrate a gas-phase alloying approach that yields ultrathin and crystalline dielectrics with attractive properties for the integration into electronics. A surface-selective deposition process was shown to produce sulfur (S) and selenium (Se) alloys with large-scale uniformity. Through combination of experimental diffraction analysis and materials modeling, we establish the crystallinity of the alloy with a modified lattice structure compared to the host materials. The resulting lattice arrangement endows the alloy dielectric with high ionic mobility as validated by electrochemical impedance spectroscopy. Leveraging this innovative feature, we fabricate memristive devices exhibiting promising performance characteristics. Our findings demonstrate the feasibility of utilizing gas-phase alloying to engineer dielectrics with superior properties and functionality for future device integration.

未来电子设备的发展需要成分更复杂、性能更强的电介质材料。我们在此展示了一种气相合金化方法,它能产生超薄、结晶的电介质,并具有极具吸引力的特性,可集成到电子设备中。研究表明,表面选择性沉积工艺可生产出具有大规模均匀性的硫 (S) 和硒 (Se) 合金。通过结合实验衍射分析和材料建模,我们确定了合金的结晶度,与主材料相比,合金的晶格结构有所改变。由此产生的晶格排列使合金电介质具有高离子迁移率,这一点已通过电化学阻抗光谱得到验证。利用这一创新特性,我们制造出了具有良好性能特点的忆阻器件。我们的研究结果证明了利用气相合金化技术制造具有优异性能和功能的电介质以实现未来器件集成的可行性。
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引用次数: 0
Construction of broad-spectrum photocatalyst films through interface engineering: Orchestrating Bi nanoparticles in TiO2/BiVO4 Z-scheme heterojunctions 通过界面工程构建广谱光催化剂薄膜:协调 TiO2/BiVO4 Z 型异质结中的生物纳米粒子
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-02 DOI: 10.1016/j.jsamd.2024.100764
Yuan-Chang Liang, Chih-Chen Kuo

We successfully synthesized three-layered photocatalysts by modifying Bi nanoparticles on TiO2/BiVO4 bilayer composite films through a sol-gel process and sputtering. When exposed to ambient air, the surface of the prepared Bi nanoparticles oxidizes to form an amorphous ultra-thin Bi2O3 out layer. Under light exposure, this layer is reduced to metallic Bi, thanks to the band alignment between the Bi nanoparticles and TiO2/BiVO4 Z-scheme composite. The addition of Bi nanoparticles in the composite films improves visible-light absorption by the surface plasmon resonance (SPR), which contributes to the hot electron and enhances the photocatalytic characteristics. By constructing effective TiO2/BiVO4 Z-scheme heterostructures to facilitate photoinduced electron-hole pair separation and prevent recombination, Bi nanoparticles can efficiently capture photons and enhance the photocatalytic efficiency of semiconductors through the SPR effect. Optimizing the content of Bi nanoparticles decorated on the TiO2/BiVO4 Z-scheme composite film is a promising approach for designing a highly efficient photocatalyst, as evidenced by the performance of photoelectrochemical properties and RhB photodegradation ability.

我们通过溶胶-凝胶工艺和溅射法在 TiO2/BiVO4 双层复合膜上改性 Bi 纳米粒子,成功合成了三层光催化剂。当暴露在环境空气中时,制备的 Bi 纳米粒子表面会氧化形成无定形的超薄 Bi2O3 外层。在光照下,由于 Bi 纳米粒子和 TiO2/BiVO4 Z 型复合材料之间的带排列,该层被还原成金属 Bi。在复合薄膜中加入 Bi 纳米粒子可通过表面等离子体共振(SPR)改善可见光吸收,从而产生热电子并增强光催化特性。通过构建有效的 TiO2/BiVO4 Z 型异质结构来促进光诱导的电子-空穴对分离并防止重组,Bi 纳米粒子可以有效地捕获光子,并通过 SPR 效应提高半导体的光催化效率。从光电化学性质和 RhB 光降解能力的表现来看,优化装饰在 TiO2/BiVO4 Z 型复合薄膜上的 Bi 纳米粒子的含量是设计高效光催化剂的一种可行方法。
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引用次数: 0
Partially oxidized polyvinyl alcohol + functionalized water soluble multiwalled carbon nanotubes: A new conductive nanocomposite material with promising implications for neuroregeneration 部分氧化聚乙烯醇+功能化水溶性多壁碳纳米管:一种新型导电纳米复合材料,有望用于神经再生
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-07-02 DOI: 10.1016/j.jsamd.2024.100762
Elena Stocco , Silvia Barbon , Ludovica Ceroni , Marta Confalonieri , Giada Pulzato , Samuel Pressi , Alice D'Osualdo , Marta Contran , Rafael Boscolo-Berto , Cesare Tiengo , Silvia Todros , Piero G. Pavan , Veronica Macchi , Raffaele De Caro , Laura Calvillo , Enzo Menna , Andrea Porzionato

Carbon nanotubes (CNT) are promising electroconductive nano-scale materials for neuroregeneration. Herein, we report on a new electroconductive composite scaffold made of the polymer 1% oxidized polyvinyl alcohol (OxPVA) combined with functionalized water soluble multiwalled CNT (OxPVA + MWCNT-S) (diazotization reaction). Preliminarily, MWCNT-S were characterized to evaluate the reaction outcome, the degree of functionalization and the dispersibility in water. Thereafter, OxPVA + MWCNT-S nanocomposite membranes were fabricated and analyzed for physicochemical properties (Raman spectroscopy, thermal decomposition, calorimetric properties, electroconductivity), macroscopic appearance and ultrastructure, mechanical behavior, in vitro cytotoxicity and in vivo biocompatibility. In parallel, OxPVA + MWCNT-S membranes with a linear pattern were also developed and analyzed for interaction with SH-SY5Y cells. Compared to OxPVA, the presence of MWCNT-S (only 0.016 wt%) significantly increased polymer conductivity and imparted a certain porosity without altering mechanical behaviour, as corroborated by uniaxial tensile tests. Neither cytotoxicity nor local signs of inflammation were detected in vitro and after subcutaneous implantation (14 and 42 days), proving composite material biocompatibility. OxPVA + MWCNT-S nanocomposite revealed as promising for future electroconductive conduits free from toxic effects amenable to CNT agglomeration within the polymer. Ideally, nerve lesions with wide gaps, may be effectively supported by those “active” devices, overcoming limitations of the available ones. Despite preliminary data, the presence of a linear pattern confirmed to have a beneficial effect over the scaffold/cells interaction.

碳纳米管(CNT)是一种很有前景的用于神经再生的纳米级导电材料。在此,我们报告了一种新型导电复合支架,由聚合物 1%氧化聚乙烯醇(OxPVA)与功能化水溶性多壁碳纳米管(OxPVA+MWCNT-S)(重氮化反应)制成。首先,对 MWCNT-S 进行表征,以评估反应结果、功能化程度和在水中的分散性。随后,制备了 OxPVA+MWCNT-S 纳米复合膜,并对其理化性质(拉曼光谱、热分解、量热性质、电导率)、宏观外观和超微结构、机械行为、细胞毒性和生物相容性进行了分析。同时,还开发了线性图案的 OxPVA+MWCNT-S 膜,并分析了其与 SH-SY5Y 细胞的相互作用。单轴拉伸测试证实,与 OxPVA 相比,MWCNT-S(仅 0.016 wt%)的存在显著提高了聚合物的导电性,并在不改变机械性能的情况下赋予其一定的多孔性。皮下植入(14 天和 42 天)后,既未发现细胞毒性,也未发现局部炎症迹象,这证明了复合材料的生物相容性。OxPVA+MWCNT-S纳米复合材料具有良好的前景,可用于未来的导电导管,且不会因CNT在聚合物中聚集而产生毒性效应。理想情况下,这些 "有源 "装置可以有效支持间隙较大的神经损伤,克服现有装置的局限性。尽管有初步数据,但线性模式的存在已证实对支架/细胞的相互作用有好处。
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引用次数: 0
Micrometric thermal electronic nose able to detect and quantify individual gases in a mixture 能够检测和量化混合物中单个气体的微量热电子鼻
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-06-27 DOI: 10.1016/j.jsamd.2024.100760
Matteo Tonezzer , Michele Ricci , Nguyen X. Thai , Hugo Nguyen , Nguyen V. Duy , Nguyen D. Hoa

Recent urbanization and environmental problems urge for networks of sensors that can monitor air quality. Small, inexpensive, and smart sensors are one of the key components enabling the realization of such networks. Chemoresistive sensors are the ideal candidate, but they greatly lack selectivity, and for this reason, they are usually combined in arrays to create electronic noses, whose dimensions, however, make them not miniaturizable and cannot be integrated into portable devices. To overcome this inconvenience, we present a thermal electronic nose consisting of identical resistive sensors working at different temperatures so that the whole device is simple to make and tiny. The device contains two sensor arrays based on tin oxide nanowires decorated with Ag and Pt nanoparticles, respectively. The five sensors in each array are identical, but their response is differentiated by different temperatures locally generated by an on-chip integrated heater. This innovative approach allows the tiny array of five sensors together with the integrated heater to occupy only approximately 50 × 200 μm2 and consume only 120 μW. The tiny and portable device can estimate the concentration of H2 and NH3 in a mixture with a root mean square error of 6.1 ppm and 13.3 ppm, respectively, and it still works well after two months. The performance analysis of the double partial least squares regression used for concentration estimation also allows for feedback on which sensors are the most sensitive to which gas so that the electronic nose can be engineered for specific applications using the most suitable sensors. The size of the thermal electronic nose allows it to be integrated into portable and wearable devices, and its performance makes it suitable for any gas detection application. For example, a smartphone with an integrated sensor could carry out breath analysis and act as medical pre-screening or be used to evaluate the freshness of agri-food products in a rapid and non-invasive way.

近来的城市化和环境问题要求建立能够监测空气质量的传感器网络。小型、廉价和智能传感器是实现此类网络的关键元件之一。化学电阻传感器是理想的选择,但它们严重缺乏选择性,因此,通常将它们组合成阵列,形成电子鼻,但其尺寸使它们无法小型化,也无法集成到便携式设备中。为了克服这种不便,我们提出了一种热敏电子鼻,它由在不同温度下工作的相同电阻传感器组成,因此整个装置的制作简单且体积小。该装置包含两个传感器阵列,分别以银和铂纳米粒子装饰的氧化锡纳米线为基础。每个阵列中的五个传感器完全相同,但它们的反应却因片上集成加热器产生的局部温度不同而有所区别。这种创新方法使得由五个传感器组成的微小阵列和集成加热器仅占大约 50 × 200 μm2 的面积,耗电量仅为 120 μW。这种微型便携式装置可以估算出混合物中 H2 和 NH3 的浓度,均方根误差分别为 6.1 ppm 和 13.3 ppm,而且两个月后仍能正常工作。对用于浓度估计的双偏最小二乘法回归进行性能分析后,还可以反馈哪些传感器对哪些气体最敏感,这样就可以使用最合适的传感器为特定应用设计电子鼻。热敏电子鼻的尺寸使其可以集成到便携式和可穿戴设备中,其性能使其适用于任何气体检测应用。例如,集成了传感器的智能手机可以进行呼气分析,作为医疗预检设备,或用于快速、无创地评估农业食品的新鲜度。
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引用次数: 0
CPP10-targeted photoactivatable MOF nanosystem for combined photodynamic Therapy−Chemotherapy of cancer 用于癌症光动力疗法-化疗联合疗法的 CPP10 靶向光活化 MOF 纳米系统
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-06-25 DOI: 10.1016/j.jsamd.2024.100761
Jiahui Kong, Mengru Cai, Rongyue Zhu, Yongqiang Zhang, Yuji Du, Xiaohong Jing, Yufei Sun, Rongrong Chang, Changhai Qu, Xiaoxv Dong, Jian Ni, Xingbin Yin

The annual prevalence of gastric cancer has increased in recent years. Curcumin (CUR) has shown great potential in the treatment of gastric cancer; however, its low bioavailability and poor efficacy hinder its widespread clinical application. Additionally, CUR has been found to be excellent photosensitizer in photodynamic therapy. In this study, the Fe-based metal-organic framework (MOF) Fe Tetrakis (4-carboxyphenyl) porphyrin (Fe-TCPP,FT) was used as a photosensitizer and mononuclear agent. The natural anti-tumor active ingredient CUR was loaded as both a chemotherapeutic agent and photosensitizer to form the nanoparticles CUR@FT (CF). Finally, a cell-penetrating peptide (CPP10) was modified on the surface of the nanoparticles to construct a drug delivery system (named CPP10-PEG@CUR@FT, CCF) that could actively target tumor cells while exerting a synergistic therapeutic effect of chemotherapy and photodynamic therapy. This can improve the efficacy of CUR as a chemotherapeutic drug or photosensitizer, and the high drug load and pH sensitivity of FT nanoparticles provide an excellent carrier for the efficient delivery of CUR. The polyethene glycol (PEG)-conjugated CPP10 (PEG-CPP10) coating allows nanoparticles to specifically target gastric cancer cells, significantly improving the absorption of nanoparticles in vivo and in vitro and improving biosafety. We evaluated the thermal stability, drug loading capacity, and safety of FT as a drug delivery vehicle. We also assessed the in vitro photodynamic performance and toxicity of various nanoparticles and the targeting and biocompatibility of CPP10-PEG@CUR@FT. CPP10-PEG@CUR@FT could specifically target tumor cells, and its effect on killing gastric cancer cells (MKN45) under light was much stronger than that of free CUR. Its toxicity and side effects to other organs and tissues are low, offering good biosafety. The experimental results showed that FT and CUR exerted synergistic effects on photodynamic therapy and chemotherapy. In summary, our novel CUR-loaded targeted nano drug delivery system offers significant advantages by combining photodynamic therapy and chemotherapy for tumor treatment. This approach introduces a new concept for integrating chemotherapy, photodynamic therapy and targeted drug delivery, potentially providing a new strategy for the clinical treatment of gastric cancer.

近年来,胃癌的发病率逐年上升。姜黄素(CUR)在治疗胃癌方面显示出巨大的潜力,但其生物利用度低、疗效差,阻碍了它在临床上的广泛应用。此外,在光动力疗法中,姜黄素被发现是一种出色的光敏剂。本研究采用铁基金属有机框架(MOF)铁四(4-羧基苯基)卟啉(Fe-TCPP,FT)作为光敏剂和单核剂。天然抗肿瘤活性成分 CUR 同时作为化疗剂和光敏剂被载入纳米粒子 CUR@FT (CF)。最后,在纳米颗粒表面修饰了一种细胞穿透肽(CPP10),构建了一种药物递送系统(CPP10-PEG@CUR@FT,CCF),该系统可以主动靶向肿瘤细胞,同时发挥化疗和光动力疗法的协同治疗作用。FT纳米颗粒的高载药量和pH敏感性为CUR的高效递送提供了良好的载体。聚乙二醇(PEG)共轭 CPP10(PEG-CPP10)涂层可使纳米颗粒特异性地靶向胃癌细胞,显著改善纳米颗粒在体内和体外的吸收,提高生物安全性。我们评估了 FT 作为给药载体的热稳定性、载药能力和安全性。我们还评估了各种纳米颗粒的体外光动力性能和毒性,以及 CPP10-PEG@CUR@FT 的靶向性和生物相容性。结果表明,CPP10-PEG@CUR@FT可特异性靶向肿瘤细胞,在光照下对胃癌细胞(MKN45)的杀伤作用远强于游离CUR。其对其他器官和组织的毒性和副作用较低,具有良好的生物安全性。实验结果表明,FT 和 CUR 在光动力治疗和化疗中具有协同作用。总之,我们的新型 CUR 靶向纳米给药系统将光动力疗法和化疗结合起来治疗肿瘤,具有显著的优势。这种方法引入了化疗、光动力疗法和靶向给药相结合的新概念,有可能为胃癌的临床治疗提供一种新策略。
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引用次数: 0
Ultrasound assisted green synthesis of silver nanoparticles stabilized by chitosan polymers: Investigation of its therapeutic application in diarrhea 超声波辅助壳聚糖聚合物稳定银纳米粒子的绿色合成:腹泻治疗应用研究
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-06-24 DOI: 10.1016/j.jsamd.2024.100759
Lin Wang , Lei Qiao , Yuzhi Liu , Fengyue Li , Attalla F. El-kott , Mohammed A. AlShehri , Kareem Morsy

The current investigation aims to study the bio route preparation of chitosan capped-silver nanoparticles using aqueous flower extract of the Achillea ptarmica plant. The biosynthesized silver nanoparticles/chitosan (Ag NPs@CHI) were characterized by various spectroscopic techniques. The creation of Ag nanoparticles over the chitosan was initially determined by the presence of a single broad peak at 545 nm that was recorded by the UV–Vis spectrum. The presence of poly-dispersity, spherical shape and nanosizes in the Ag NPs@CHI were verified by the TEM and SEM pictures. The purity and crystalline nature of the prepared Ag NPs@CHI were confirmed by XRD analysis. In vivo, Ag NPs@CHI decreased the inflammatory cells presence in the colon and ileum, lowered the levels of IL-17A, IL-1β, IL-6, and TNF-α, raised the levels of IL-10 and IL-4 in colon tissues, enhanced acetate and propionate production. The findings revealed that Ag NPs@CHI have the potential to boost intestinal structure restoration, decrease levels of inflammatory cytokines and enhance short-chain fatty acid (SCFA) levels. Our research demonstrated that Ag NPs@CHI can safeguard the intestinal barrier by upregulating the expression of Claudin-1 and Occludin. Furthermore, silver nanoparticles suppressed the MAPK signaling pathway to ameliorate the inflammatory condition. Following the completion of clinical trials, these novel nanoparticles could serve as a promising new treatment for diarrhea in humans.

目前的研究旨在利用蓍草花的水提取物,通过生物途径制备壳聚糖封端银纳米粒子。通过各种光谱技术对生物合成的银纳米粒子/壳聚糖(Ag NPs@CHI)进行了表征。通过紫外可见光谱记录的 545 纳米波长处的单个宽峰,初步确定了壳聚糖上银纳米粒子的形成。通过 TEM 和 SEM 照片验证了 Ag NPs@CHI 的多分散性、球形和纳米尺寸。XRD 分析证实了制备的 Ag NPs@CHI 的纯度和结晶性质。在体内,Ag NPs@CHI 减少了结肠和回肠中炎症细胞的存在,降低了 IL-17A、IL-1β、IL-6 和 TNF-α 的水平,提高了结肠组织中 IL-10 和 IL-4 的水平,促进了乙酸盐和丙酸盐的产生。研究结果表明,Ag NPs@CHI具有促进肠道结构恢复、降低炎性细胞因子水平和提高短链脂肪酸(SCFA)水平的潜力。我们的研究表明,银纳米粒子@CHI可通过上调Claudin-1和Occludin的表达来保护肠道屏障。此外,银纳米粒子还能抑制 MAPK 信号通路,从而改善炎症状况。在完成临床试验后,这些新型纳米粒子有望成为治疗人类腹泻的新疗法。
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引用次数: 0
Enhancement of the microwave absorption properties of the SrFe12O19@Fe3O4@rGO composite material 增强 SrFe12O19@Fe3O4@rGO 复合材料的微波吸收特性
IF 6.7 3区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY Pub Date : 2024-06-16 DOI: 10.1016/j.jsamd.2024.100758
Tran Thi Viet Nga , Nguyen Thi Lan , To Thanh Loan , Tran Quang Dat

In this work, graphene oxide (GO) was prepared via the Hummers’ method, whereas SrFe12O19, SrFe12O19@Fe3O4, and SrFe12O19@Fe3O4@rGO were fabricated using the hydrothermal techniques. The samples' phase structure, surface morphology, magnetic properties, and electromagnetic wave absorption characteristics were studied and compared. Findings show that the Fe3O4 particles adhered to the surface of the SrFe12O19 hexagonal plates, and the combination of SrFe12O19@Fe3O4 foam flakes and two-dimensional graphene rGO could enhance the absorption electromagnetic wave performance. The composite SrFe12O19@Fe3O4@rGO sample exhibited an ideal impedance matching within the frequency f range of 11 GHz–12.4 GHz. The minimum reflection loss reached −62.3 dB at 12.2 GHz with a thickness of 2 mm. With a thickness of 2 mm, the effective absorption bandwidth obtained the value of −20 dB, covering a range of 9.3 GHz. The composite SrFe12O19@Fe3O4@rGO sample, which shows the highest performance both in reflectivity and bandwidth, can find potential application in microwave absorptions.

本研究采用 Hummers 法制备了氧化石墨烯 (GO),并利用水热技术制备了 SrFe12O19、SrFe12O19@Fe3O4 和 SrFe12O19@Fe3O4@rGO。研究并比较了样品的相结构、表面形貌、磁性能和电磁波吸收特性。研究结果表明,Fe3O4 颗粒附着在 SrFe12O19 六角板的表面,SrFe12O19@Fe3O4 泡沫薄片与二维石墨烯 rGO 的结合可以增强吸收电磁波的性能。复合 SrFe12O19@Fe3O4@rGO 样品在 11 GHz-12.4 GHz 频率 f 范围内表现出理想的阻抗匹配。厚度为 2 毫米的样品在 12.2 GHz 时的最小反射损耗为 -62.3 dB。厚度为 2 毫米时,有效吸收带宽为 -20 dB,频率范围为 9.3 GHz。复合 SrFe12O19@Fe3O4@rGO 样品在反射率和带宽方面都表现出了最高的性能,有望应用于微波吸收领域。
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引用次数: 0
Silver nanoparticles stabilized by chitosan-polyvinyl alcohol polymers mediated by Pistacia extract for treatment of functional dyspepsia and gastric cancer 由壳聚糖-聚乙烯醇聚合物稳定的银纳米粒子,以楷模提取物为介质,用于治疗功能性消化不良和胃癌
IF 6.7 3区 材料科学 Q1 Materials Science Pub Date : 2024-06-08 DOI: 10.1016/j.jsamd.2024.100757
Cui Jin , Zhongxin Zhang , Xiaopei Li

The impact of the nanoparticles on the dyspepsia mice gut microbiota is evaluated through the utilization of the 16S rRNA technique. Various methods were employed to characterize the NPs. In the textile, culinary, paper, leather, and printing sectors, synthetic dyes are frequently employed as coloring agents. Because these dye molecules are harmful to both the environment and living things, it is difficult to remove them sustainably. Here, we have produced nanoparticles embedded in chitosan-polyvinyl alcohol hydrogel (CS-PVA) by using bark's Pistacia under ultrasonic irradiation. The reduction of Ag + ions into Ag0 NPs was detected by a visual change in the colors. UV–Vis analysis indicated that the characteristic SPR band appeared near ∼440–450 nm. UV/Vis, EDX-elemental mapping, SEM, TEM, ICP-OES, and XRD analysis were applied to characterize the Ag NPs/CS-PVA nanocomposite. The recent study focused on the cellular and molecular aspects. The MTT assay was conducted for 48 h to evaluate the anti-human gastric cancer and cytotoxicity efficacies of the treated cells with nanocomposite. The assessment was performed on normal (HUVEC) and gastric cancer cells, namely MKN45 and NCI–N87. The IC50 values of nanocomposite against MKN45 and NCI–N87 were 180 and 151 μg/mL, respectively. The dose-dependent reduction in malignant gastric cell viability was observed in the nanocomposite presence. Furthermore, the nanocomposite induced cell apoptosis by 40–50%, leading to an increase in the expression of pro-apoptotic markers (Bax and cleaved caspase-8) and a decrease in the expression of the anti-apoptotic marker, Bcl-2. Furthermore, the nanocomposite showed inhibitory effects on colony formation. Our results indicate that the nanocomposite can increase p53 expression and decrease the expression of STAT3 in treated cells. This indicates that p53 and STAT3 play crucial roles in the biological effects induced by the extract in human gastric carcinoma cells. The data from the gut microbiome suggested that nanocomposites have the ability to control the rebalancing of homeostasis and microbiome composition by decreasing the levels of harmful bacteria, and at the same time, increasing the levels of beneficial bacteria. Following the introduction of nanocomposite, there was an observed rise in the levels of gastrointestinal hormones in the serum, including gastrin and motilin, while the levels of vasoactive intestinal peptide decreased. The application of nanocomposite led to an improvement in gastrointestinal movement, encompassing a rise in the rate of transit through the small intestine and the rate of gastric emptying. These findings offer that the Ag NPs/CS-PVA nanocomposite could be a promising anticancer treatment for functional dyspepsia and gastric cancer.

利用 16S rRNA 技术评估了纳米粒子对消化不良小鼠肠道微生物群的影响。采用了多种方法对纳米粒子进行表征。在纺织、烹饪、造纸、皮革和印刷行业,合成染料经常被用作着色剂。由于这些染料分子对环境和生物都有害,因此很难可持续地去除它们。在此,我们利用树皮中的楷属植物,在超声波照射下制备了嵌入壳聚糖-聚乙烯醇水凝胶(CS-PVA)中的纳米粒子。Ag + 离子还原成 Ag0 NPs 的过程是通过颜色的视觉变化来检测的。紫外可见光分析表明,特征 SPR 波段出现在 ∼440-450 nm 附近。紫外可见光谱、EDX 元素图谱、扫描电子显微镜、电子显微镜、ICP-OES 和 XRD 分析被用于表征 Ag NPs/CS-PVA 纳米复合材料。最近的研究侧重于细胞和分子方面。为了评估纳米复合材料处理细胞的抗人胃癌和细胞毒性效果,对细胞进行了 48 小时的 MTT 试验。评估对象是正常细胞(HUVEC)和胃癌细胞,即 MKN45 和 NCI-N87。纳米复合材料对 MKN45 和 NCI-N87 的 IC50 值分别为 180 和 151 μg/mL。在纳米复合材料存在的情况下,恶性胃细胞存活率的降低呈剂量依赖性。此外,纳米复合材料可诱导细胞凋亡 40-50%,导致促凋亡标志物(Bax 和裂解的 caspase-8)的表达增加,而抗凋亡标志物 Bcl-2 的表达减少。此外,纳米复合材料还对集落形成有抑制作用。我们的研究结果表明,纳米复合材料能增加处理细胞中 p53 的表达,降低 STAT3 的表达。这表明 p53 和 STAT3 在提取物诱导的人胃癌细胞生物效应中起着关键作用。来自肠道微生物组的数据表明,纳米复合材料有能力通过降低有害细菌的水平,同时提高有益细菌的水平来控制平衡和微生物组组成的再平衡。引入纳米复合材料后,观察到血清中胃肠激素(包括胃泌素和胃动素)的水平上升,而血管活性肠肽的水平下降。纳米复合材料的应用改善了胃肠道运动,包括提高了小肠转运率和胃排空率。这些研究结果表明,Ag NPs/CS-PVA 纳米复合材料可能是治疗功能性消化不良和胃癌的一种很有前景的抗癌疗法。
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引用次数: 0
Adsorption of dimethylaluminum isopropoxide (DMAI) on the Al2O3 surface: A machine-learning potential study Al2O3 表面对二甲基异丙醇铝 (DMAI) 的吸附:机器学习潜力研究
IF 8 3区 材料科学 Q1 Materials Science Pub Date : 2024-06-04 DOI: 10.1016/j.jsamd.2024.100754
Miso Kim, Sehee Kim, Bonggeun Shong

Dimethylaluminum isopropoxide (DMAI) is attracting attention as an alternative precursor for atomic layer deposition (ALD) of aluminum oxide (Al2O3). However, the surface chemical reaction mechanisms of DMAI during ALD regarding its dimeric structure under vacuum deposition process conditions has yet to be clear. In this work, the adsorption mechanism of dimeric and monomeric DMAI on a fully hydroxylated Al2O3 surface is studied using machine-learning potential (MLP) calculations. The initial adsorption of DMAI appears facile and would result in the coexistence of both methyl and isopropoxy ligands on the surface. The reactivity of DMAI is smaller than that of TMA, owing to the propensity of DMAI to adopt a dimeric form. Especially when the substrate is partially covered by other adsorbate species, the large molecular size and low reactivity of dimeric DMAI considerably hinder its reactivity toward surface adsorption. Current results are in good correspondence with the previous experimental results, where lower growth per cycle (GPC) and higher selectivity in area-selective ALD (AS-ALD) could be observed by using DMAI than compared to those of TMA processes.

二甲基异丙醇铝(DMAI)作为氧化铝(Al2O3)原子层沉积(ALD)的替代前驱体备受关注。然而,在真空沉积工艺条件下,DMAI 的二聚体结构在 ALD 过程中的表面化学反应机制尚未明确。本研究利用机器学习势(MLP)计算方法研究了二聚体和单体 DMAI 在完全羟基化的 Al2O3 表面上的吸附机理。DMAI 的初始吸附似乎很容易,会导致甲基配体和异丙氧基配体在表面共存。DMAI 的反应活性小于 TMA,这是因为 DMAI 倾向于采用二聚形式。特别是当基底被其他吸附物部分覆盖时,二聚 DMAI 的大分子尺寸和低反应活性大大阻碍了其对表面吸附的反应活性。目前的结果与之前的实验结果非常吻合,与 TMA 工艺相比,使用 DMAI 的区域选择性 ALD(AS-ALD)每周期生长量(GPC)更低,选择性更高。
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引用次数: 0
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Journal of Science: Advanced Materials and Devices
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