N. Alizadeh, R. Rafiei, A. Darjani, H. Eftekhari, K. Nejad, E. Rafiei, Meghdad Nasiri
Background Some micronutrients including selenium (Se) have immunoregulatory effects in the body. Our hypothesis was that decreased serum Se levels could be associated with some degree of immunodeficiency and increased chance of multiple cutaneous warts. Objective To measure serum Se levels in patients with multiple cutaneous warts and healthy participants to verify its inhibitory role in cutaneous warts. Patients and methods A case–control study was conducted on 136 participants: 68 cases with multiple cutaneous warts and 68 age-matched and sex-matched healthy controls. Collected data were age, sex, number, duration, and clinical type of the warts. Blood samples were taken from all participants for the evaluation of serum Se level. Se level was measured with atomic absorption method. Results Median of the Se level was significantly lower in patients with multiple warts compared with healthy controls (P<0.05), but the frequency of Se deficiency was not significantly different in the two groups. There was not any association between Se level and number of warts, but it was significantly lower in palmoplantar warts compared with genital warts. Conclusion A significant decrease in median Se level in patients with multiple warts even without Se deficiency may cause some decline in immune system against papillomaviruses. Lack of Se deficiency in the north of Iran may have led to nonsignificant differences in the frequency of Se deficiency in the two groups.
{"title":"Evaluation of serum selenium levels in patients with multiple warts: a case–control study in the north of Iran","authors":"N. Alizadeh, R. Rafiei, A. Darjani, H. Eftekhari, K. Nejad, E. Rafiei, Meghdad Nasiri","doi":"10.4103/jewd.jewd_37_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_37_21","url":null,"abstract":"Background Some micronutrients including selenium (Se) have immunoregulatory effects in the body. Our hypothesis was that decreased serum Se levels could be associated with some degree of immunodeficiency and increased chance of multiple cutaneous warts. Objective To measure serum Se levels in patients with multiple cutaneous warts and healthy participants to verify its inhibitory role in cutaneous warts. Patients and methods A case–control study was conducted on 136 participants: 68 cases with multiple cutaneous warts and 68 age-matched and sex-matched healthy controls. Collected data were age, sex, number, duration, and clinical type of the warts. Blood samples were taken from all participants for the evaluation of serum Se level. Se level was measured with atomic absorption method. Results Median of the Se level was significantly lower in patients with multiple warts compared with healthy controls (P<0.05), but the frequency of Se deficiency was not significantly different in the two groups. There was not any association between Se level and number of warts, but it was significantly lower in palmoplantar warts compared with genital warts. Conclusion A significant decrease in median Se level in patients with multiple warts even without Se deficiency may cause some decline in immune system against papillomaviruses. Lack of Se deficiency in the north of Iran may have led to nonsignificant differences in the frequency of Se deficiency in the two groups.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"19 1","pages":"39 - 43"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46951182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Skin is considered as the mirror of the body’s health, and thus, prevention or treatment of any skin problems is an important idea. Algae are among the wealthiest aquatic commodities that are considered healthy and have negligible effect on human cytotoxicity. They are considered as a resourceful material for bioactive compounds, including vitamins, polyphenolic compounds, carotenoids, chitin, and others that have been reported to have powerful skin benefits. Algae products are now being commercialized as skin care products, and their effectiveness in treating skin problems such as rashes, pigmentation and ageing is well proven. In this review, we summarize the important algal bioactive ingredients and their effects on skin. Moreover, the review reports some studies concerning the use of algae components for skin care. Algae use in cosmeceuticals’ industry offers a safe, healthier, and economic alternative for synthetic products.
{"title":"An overview of algae prospects in cosmeceuticals","authors":"G. El-Chaghaby, S. Rashad","doi":"10.4103/jewd.jewd_22_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_22_21","url":null,"abstract":"Skin is considered as the mirror of the body’s health, and thus, prevention or treatment of any skin problems is an important idea. Algae are among the wealthiest aquatic commodities that are considered healthy and have negligible effect on human cytotoxicity. They are considered as a resourceful material for bioactive compounds, including vitamins, polyphenolic compounds, carotenoids, chitin, and others that have been reported to have powerful skin benefits. Algae products are now being commercialized as skin care products, and their effectiveness in treating skin problems such as rashes, pigmentation and ageing is well proven. In this review, we summarize the important algal bioactive ingredients and their effects on skin. Moreover, the review reports some studies concerning the use of algae components for skin care. Algae use in cosmeceuticals’ industry offers a safe, healthier, and economic alternative for synthetic products.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"161 - 166"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48670927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Idiopathic calcinosis cutis is characterized by multiple nodules present on scrotal skin. They are usually seen in young adults and present as painless, asymptomatic, round, and firm nodules. A 30-year-old male presented with painless, multiple scrotal nodules. The serum levels of calcium, phosphorus, calcitonin, and parathyroid hormone were within normal limits. There was also no history of trauma. Clinically, it was diagnosed as sebaceous cyst. Fine-needle aspiration cytology examination was suggestive of epidermal inclusion cyst. Histopathology examination confirmed the diagnosis of idiopathic scrotal calcinosis cutis, thus suggesting that the dystrophic calcification of epidermal inclusion may be an initiating event in the pathogenesis of the idiopathic scrotal calcinosis cutis. The documentations regarding the association of idiopathic calcinosis cutis with epidermal cyst are not enough. Hence, this case report may enrich the scanty existing data.
{"title":"Idiopathic Scrotal calcinosis cutis – does its pathogenesis link with epidermal cyst? A case report with review of literature from rural India","authors":"M. Krishna, S. Dayal","doi":"10.4103/jewd.jewd_32_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_32_21","url":null,"abstract":"Idiopathic calcinosis cutis is characterized by multiple nodules present on scrotal skin. They are usually seen in young adults and present as painless, asymptomatic, round, and firm nodules. A 30-year-old male presented with painless, multiple scrotal nodules. The serum levels of calcium, phosphorus, calcitonin, and parathyroid hormone were within normal limits. There was also no history of trauma. Clinically, it was diagnosed as sebaceous cyst. Fine-needle aspiration cytology examination was suggestive of epidermal inclusion cyst. Histopathology examination confirmed the diagnosis of idiopathic scrotal calcinosis cutis, thus suggesting that the dystrophic calcification of epidermal inclusion may be an initiating event in the pathogenesis of the idiopathic scrotal calcinosis cutis. The documentations regarding the association of idiopathic calcinosis cutis with epidermal cyst are not enough. Hence, this case report may enrich the scanty existing data.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"219 - 221"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46596802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hyper IgE syndrome in the neonatal period: an unusual presentation","authors":"S. Yadav, K. Bhalla, Ashish Gupta, Poonam Dalal","doi":"10.4103/jewd.jewd_54_20","DOIUrl":"https://doi.org/10.4103/jewd.jewd_54_20","url":null,"abstract":"","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"229 - 230"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49162694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prurigo Pigmentosa is a rare inflammatory dermatosis, first described in Japan in 1971. It has been recently reported to occur in patients on restrictive diets. In severe nutritional deficiencies, neuropathies have been reported. This report describes a rare case of both prurigo pigmentosa with sensory dysesthesia while following a ketogenic diet.
{"title":"Annular prurigo pigmentosa with sensory dysthesia with ketogenic diet: a case report","authors":"P. Mostafa","doi":"10.4103/jewd.jewd_11_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_11_21","url":null,"abstract":"Prurigo Pigmentosa is a rare inflammatory dermatosis, first described in Japan in 1971. It has been recently reported to occur in patients on restrictive diets. In severe nutritional deficiencies, neuropathies have been reported. This report describes a rare case of both prurigo pigmentosa with sensory dysesthesia while following a ketogenic diet.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"225 - 228"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46511482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Vitiligo is the most commonly acquired depigmenting disorder. It has a negative psychological impact on affected individuals. The pathogenesis of vitiligo is complex and not yet fully revealed. Phosphodiesterase (PDE) inhibitors are widely used in many medical diseases and dermatological conditions, for example, psoriasis and atopic dermatitis. Recently, a case report showed that Apremilast (PDE4 inhibitor) resulted in significant repigmentation in a female patient with recalcitrant vitiligo. Objective To evaluate PDE4 levels in the tissues and serum of vitiligo patients and to compare them to the levels of controls to assess its role in the pathogenesis of the disease. Patients and methods In this case-control study, skin biopsies of vitiliginous lesions and blood samples were taken from 20 vitiligo patients and 20 controls. The PDE4 enzyme level was measured in both skin and serum samples. Results PDE4 enzyme levels in both the skin and serum of vitiligo patients were significantly higher than those in controls. PDE4 enzyme tissue levels were significantly higher than serum levels of both groups (patients and controls). A significant positive correlation was found between PDE4 tissue and serum levels of vitiligo patients. Conclusion High PDE4 levels in tissue and serum of vitiligo patients compared with controls suggest that it may contribute to the pathogenesis of vitiligo. Hence, PDE4 inhibitors may be a promising therapeutic modality of this disease.
{"title":"Evaluation of phosphodiesterase 4 enzyme levels in lesional skin and serum of vitiligo patients","authors":"N. Nagui, Basma Gaballah, L. Rashed, Iman Sany","doi":"10.4103/jewd.jewd_20_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_20_21","url":null,"abstract":"Background Vitiligo is the most commonly acquired depigmenting disorder. It has a negative psychological impact on affected individuals. The pathogenesis of vitiligo is complex and not yet fully revealed. Phosphodiesterase (PDE) inhibitors are widely used in many medical diseases and dermatological conditions, for example, psoriasis and atopic dermatitis. Recently, a case report showed that Apremilast (PDE4 inhibitor) resulted in significant repigmentation in a female patient with recalcitrant vitiligo. Objective To evaluate PDE4 levels in the tissues and serum of vitiligo patients and to compare them to the levels of controls to assess its role in the pathogenesis of the disease. Patients and methods In this case-control study, skin biopsies of vitiliginous lesions and blood samples were taken from 20 vitiligo patients and 20 controls. The PDE4 enzyme level was measured in both skin and serum samples. Results PDE4 enzyme levels in both the skin and serum of vitiligo patients were significantly higher than those in controls. PDE4 enzyme tissue levels were significantly higher than serum levels of both groups (patients and controls). A significant positive correlation was found between PDE4 tissue and serum levels of vitiligo patients. Conclusion High PDE4 levels in tissue and serum of vitiligo patients compared with controls suggest that it may contribute to the pathogenesis of vitiligo. Hence, PDE4 inhibitors may be a promising therapeutic modality of this disease.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"186 - 190"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48922313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Alopecia areata (AA) is an autoimmune disease of the hair follicles, in which both innate and adaptive immunity are involved. Several factors have been linked to its etiopathogenesis, including genetic predisposition, autoimmunity, proinflammatory cytokines, and other triggering factors. Objective To measure serum interleukin-33 (IL-33) in AA patients and study its relation to different disease-related and patient-related factors. Patients and methods In total, 40 AA patients and 40 controls were enrolled. Clinical disease severity was determined and severity of alopecia tool score was calculated. Disease activity was evaluated. Serum IL-33 was measured using enzyme-linked immunosorbent assay and investigated in relation to the different studied variables. Results Significantly higher levels of IL-33 were detected in sera of patients compared with controls (P<0.001). IL-33 showed a significant positive correlation with clinical disease severity (P=0.044), severity of alopecia tool score (P=0.004), and disease duration (P=0.023). IL-33 was significantly higher in patients with chronic disease compared with those with acute disease (P=0.037). No significant relation was detected between disease activity and IL-33 (P=0.963). Receiver-operating characteristic analysis revealed a cut-off value of 14.02 pg/ml for IL-33 to be diagnostic of AA. Conclusion The elevated IL-33 in patients, in addition to the relation of IL-33 with disease severity and chronicity, could point to its possible role in the pathogenesis of AA and to its potential value as a diagnostic biomarker and as a therapeutic target.
{"title":"Serum levels of interleukin-33 in alopecia areata: relation to disease severity and chronicity","authors":"A. Eid, Y. Issa, E. Maksoud, Fairouz Badran","doi":"10.4103/jewd.jewd_31_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_31_21","url":null,"abstract":"Background Alopecia areata (AA) is an autoimmune disease of the hair follicles, in which both innate and adaptive immunity are involved. Several factors have been linked to its etiopathogenesis, including genetic predisposition, autoimmunity, proinflammatory cytokines, and other triggering factors. Objective To measure serum interleukin-33 (IL-33) in AA patients and study its relation to different disease-related and patient-related factors. Patients and methods In total, 40 AA patients and 40 controls were enrolled. Clinical disease severity was determined and severity of alopecia tool score was calculated. Disease activity was evaluated. Serum IL-33 was measured using enzyme-linked immunosorbent assay and investigated in relation to the different studied variables. Results Significantly higher levels of IL-33 were detected in sera of patients compared with controls (P<0.001). IL-33 showed a significant positive correlation with clinical disease severity (P=0.044), severity of alopecia tool score (P=0.004), and disease duration (P=0.023). IL-33 was significantly higher in patients with chronic disease compared with those with acute disease (P=0.037). No significant relation was detected between disease activity and IL-33 (P=0.963). Receiver-operating characteristic analysis revealed a cut-off value of 14.02 pg/ml for IL-33 to be diagnostic of AA. Conclusion The elevated IL-33 in patients, in addition to the relation of IL-33 with disease severity and chronicity, could point to its possible role in the pathogenesis of AA and to its potential value as a diagnostic biomarker and as a therapeutic target.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"210 - 214"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43782456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Alizadeh, R. Rafiei, A. Darjani, H. Eftekhari, K. Nejad, E. Rafiei, M. Vishkaei
Background Chronic telogen effluvium (CTE) is a form of diffuse hair loss in middle-aged women in whom telogen hair loss continues more than 6 months without obvious etiology. Disturbance in growth hair cycle may result in increased hairs in the telogen phase. Micronutrient deficiency, such as iron, zinc, and vitamin D, has been incriminated in acute telogen effluvium but its role in chronic phases is challenging. Objective To measure the levels of serum ferritin, zinc, and 25-hydroxy vitamin D (25OH vitamin D) in females with CTE and controls to verify their role in hair-loss pathogenesis. Patients and methods A case–control study was conducted on 166 female participants: 83 patients with CTE and 83 age-matched healthy controls. Blood samples were taken from all participants for evaluation of serum ferritin, zinc, and 25OH vitamin D levels. Ferritin and 25OH vitamin D levels were measured with chemiluminescence method and zinc level was measured with colorimetric method. The study was done during 6 months (autumn and winter). Results There was no significant difference in serum ferritin, zinc, and 25OH vitamin D levels in two groups. The median of ferritin level was suboptimal in both groups (≤40 μg/l). Interestingly, zinc and 25OH vitamin D levels in healthy participants were lower than patients with CTE, but with considering the significance level of 0.01, this difference was not significant. The frequency of suboptimal levels of ferritin, 25OH vitamin D, and zinc was not significantly different in two groups. Conclusion We found no significant difference in ferritin, 25OH vitamin D, and zinc levels in two groups, but the role of these micronutrients in CTE could not be ignored. It seems that suboptimal levels of ferritin and 25OH vitamin D in women are common and may have led this non significant difference.
{"title":"Chronic telogen effluvium in women: role of micronutrients, a case–control study in north of Iran","authors":"N. Alizadeh, R. Rafiei, A. Darjani, H. Eftekhari, K. Nejad, E. Rafiei, M. Vishkaei","doi":"10.4103/jewd.jewd_34_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_34_21","url":null,"abstract":"Background Chronic telogen effluvium (CTE) is a form of diffuse hair loss in middle-aged women in whom telogen hair loss continues more than 6 months without obvious etiology. Disturbance in growth hair cycle may result in increased hairs in the telogen phase. Micronutrient deficiency, such as iron, zinc, and vitamin D, has been incriminated in acute telogen effluvium but its role in chronic phases is challenging. Objective To measure the levels of serum ferritin, zinc, and 25-hydroxy vitamin D (25OH vitamin D) in females with CTE and controls to verify their role in hair-loss pathogenesis. Patients and methods A case–control study was conducted on 166 female participants: 83 patients with CTE and 83 age-matched healthy controls. Blood samples were taken from all participants for evaluation of serum ferritin, zinc, and 25OH vitamin D levels. Ferritin and 25OH vitamin D levels were measured with chemiluminescence method and zinc level was measured with colorimetric method. The study was done during 6 months (autumn and winter). Results There was no significant difference in serum ferritin, zinc, and 25OH vitamin D levels in two groups. The median of ferritin level was suboptimal in both groups (≤40 μg/l). Interestingly, zinc and 25OH vitamin D levels in healthy participants were lower than patients with CTE, but with considering the significance level of 0.01, this difference was not significant. The frequency of suboptimal levels of ferritin, 25OH vitamin D, and zinc was not significantly different in two groups. Conclusion We found no significant difference in ferritin, 25OH vitamin D, and zinc levels in two groups, but the role of these micronutrients in CTE could not be ignored. It seems that suboptimal levels of ferritin and 25OH vitamin D in women are common and may have led this non significant difference.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"205 - 209"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43694269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Youssef, R. Hay, Ahmed Aboulghate, Nahed Ibrahim, A. Hegazy, K. Sayed
Background Emerging evidence now suggests an association between Mycosis fungoides (MF) and metabolic risk factors. Objective To investigate a possible association between MF and metabolic syndrome (MetS). Patients and methods This study was designed as an observational, case-control study. It included thirty MF patients and 39 controls who were assessed for body mass index (BMI), waist circumference, blood pressure, fasting blood glucose, triglycerides (TG), total cholesterol, high and low density lipoproteins, serum leptin level and insulin resistance. Results Our results revealed that serum leptin level (P=0.029), TG (P=0.004), cholesterol (P=0.001) and LDL (P=0.019), waist circumference in males (P<0.003), hypertension (P=0.039) and frequency of metabolic syndrome (P=0.042), are statistically significantly higher in MF patients than controls. Conclusion Our results indicate that patients with MF may be at higher risk for metabolic syndrome. Concurrently, screening for metabolic syndrome is recommended for all MF cases for early detection of cardiovascular risk.
{"title":"Mycosis fungoides and metabolic syndrome: A hospital-based case-control study","authors":"R. Youssef, R. Hay, Ahmed Aboulghate, Nahed Ibrahim, A. Hegazy, K. Sayed","doi":"10.4103/jewd.jewd_10_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_10_21","url":null,"abstract":"Background Emerging evidence now suggests an association between Mycosis fungoides (MF) and metabolic risk factors. Objective To investigate a possible association between MF and metabolic syndrome (MetS). Patients and methods This study was designed as an observational, case-control study. It included thirty MF patients and 39 controls who were assessed for body mass index (BMI), waist circumference, blood pressure, fasting blood glucose, triglycerides (TG), total cholesterol, high and low density lipoproteins, serum leptin level and insulin resistance. Results Our results revealed that serum leptin level (P=0.029), TG (P=0.004), cholesterol (P=0.001) and LDL (P=0.019), waist circumference in males (P<0.003), hypertension (P=0.039) and frequency of metabolic syndrome (P=0.042), are statistically significantly higher in MF patients than controls. Conclusion Our results indicate that patients with MF may be at higher risk for metabolic syndrome. Concurrently, screening for metabolic syndrome is recommended for all MF cases for early detection of cardiovascular risk.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"174 - 178"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45419596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background Various treatments for hypertrophic scars (HTS) and keloids are available. Not all treatment modalities have been adequately tested. Recently, it has been shown that botulinum toxin type A (BTX) positively affects wound healing, so it might contribute in treating HTS and keloids. Objective To assess the effect of BTX intralesional injection as a monotherapy for the treatment of HTS and keloids clinically and histopathologically. Patients and methods A total of 30 patients with HTS and keloids were treated by intralesional injection of BTX as a monotherapy. Each lesion was injected with BTX (5 IU/cm2 once every 4 weeks for four sessions). Immunohistochemical evaluation of the lesions before and after treatment was done. Moreover, Vancouver scar scale and clinical imaging were taken before and after treatment. Results There was a highly significant difference after treatment with BTX intralesional in both the epidermal thickness (P=0.001) and area% of fibroblast dermis (P=0.001). Additionally, there was a significant decline in Vancouver scar scale after treatment (P<0.001). Conclusion BTX injection of HTS and keloids can be considered as a promising effective and well tolerated therapeutic option acting on fibroblast activity of HTS and keloids.
{"title":"Clinical and histopathological assessment of botulinum toxin-A injection for treatment of hypertrophic scars and keloids","authors":"S. Elfiky, H. Shokeir, M. Elbasiouny, N. Samy","doi":"10.4103/jewd.jewd_28_21","DOIUrl":"https://doi.org/10.4103/jewd.jewd_28_21","url":null,"abstract":"Background Various treatments for hypertrophic scars (HTS) and keloids are available. Not all treatment modalities have been adequately tested. Recently, it has been shown that botulinum toxin type A (BTX) positively affects wound healing, so it might contribute in treating HTS and keloids. Objective To assess the effect of BTX intralesional injection as a monotherapy for the treatment of HTS and keloids clinically and histopathologically. Patients and methods A total of 30 patients with HTS and keloids were treated by intralesional injection of BTX as a monotherapy. Each lesion was injected with BTX (5 IU/cm2 once every 4 weeks for four sessions). Immunohistochemical evaluation of the lesions before and after treatment was done. Moreover, Vancouver scar scale and clinical imaging were taken before and after treatment. Results There was a highly significant difference after treatment with BTX intralesional in both the epidermal thickness (P=0.001) and area% of fibroblast dermis (P=0.001). Additionally, there was a significant decline in Vancouver scar scale after treatment (P<0.001). Conclusion BTX injection of HTS and keloids can be considered as a promising effective and well tolerated therapeutic option acting on fibroblast activity of HTS and keloids.","PeriodicalId":17298,"journal":{"name":"Journal of the Egyptian Women's Dermatologic Society","volume":"18 1","pages":"191 - 197"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48310938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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