K. Yamaoka, Motohiro Nishikawa, Yoshihiro Saito, Takatoshi Sato
The stability of dexamethasone (DMS) in vanishing creams of various pH was studied. Vanishing creams containing 1% MDS were exposed to air at 40° and stability of DMS was measured by using high speed liquid chromatography (HSLC). The conditions of HSLC were as follows: model: JASCO FLC-350; detector: UVIDEC-1; wavelength: 239nm; column: HP-01 (copolymer of styrene-divinylbenzene) 4.5×250 mm; mobile phase: MeOH; flow rate: 1 ml/min; pressure: 40kg/cm2 (at room temperature). The extracted DMS was directly injected into the HSLC column and its stability was determined from the peak height of DMS on the chromatogram. It was found that DMS in vanishing creams was unstable under the basic condition and the decomposition product of DMS in vanishing creams was 3, 17-ketosteroid.
{"title":"Stability Test of Dexamethasone in Vanishing Creams of Various pH by High Speed Liquid Chromatography","authors":"K. Yamaoka, Motohiro Nishikawa, Yoshihiro Saito, Takatoshi Sato","doi":"10.5649/JJPHCS1975.6.99","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.6.99","url":null,"abstract":"The stability of dexamethasone (DMS) in vanishing creams of various pH was studied. Vanishing creams containing 1% MDS were exposed to air at 40° and stability of DMS was measured by using high speed liquid chromatography (HSLC). The conditions of HSLC were as follows: model: JASCO FLC-350; detector: UVIDEC-1; wavelength: 239nm; column: HP-01 (copolymer of styrene-divinylbenzene) 4.5×250 mm; mobile phase: MeOH; flow rate: 1 ml/min; pressure: 40kg/cm2 (at room temperature). The extracted DMS was directly injected into the HSLC column and its stability was determined from the peak height of DMS on the chromatogram. It was found that DMS in vanishing creams was unstable under the basic condition and the decomposition product of DMS in vanishing creams was 3, 17-ketosteroid.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"48 1","pages":"99-102"},"PeriodicalIF":0.0,"publicationDate":"1980-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82241094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1980-01-01DOI: 10.5649/jjphcs1975.6.134
Shôji Watanabe
Demand for drugs at hospitals, under the inevitable effect of various uncertain factors, shows constant fluctuations. Therefore, in the inventory control of drugs, the forecast for demand has a close relation with the inventory levels. The exponential smoothing, as the extension of the weighted method of moving average, is practically very useful, for example, for the adjustment of the rate of response to the changes in demand. We have applied the second-order system of exponential smoothing in the forecast of the linear model demand in the inventory control of drugs. “ The sum of the absolute value of the forecast errors” and “the absolute value of the running sum of the forecast errors” were calculated. Then, regarding their ranking as the minus points, the 2 smoothing systems were evaluated by adding up those points. In consequence, it was found out that the first-order system of smoothing is apt to cause delayed response and that the second-order system of exponential smoothing may enable to make more accurate estimation of the expected demand.
{"title":"Second-order System of Exponential Smoothing in Forecast for Drug Demand","authors":"Shôji Watanabe","doi":"10.5649/jjphcs1975.6.134","DOIUrl":"https://doi.org/10.5649/jjphcs1975.6.134","url":null,"abstract":"Demand for drugs at hospitals, under the inevitable effect of various uncertain factors, shows constant fluctuations. Therefore, in the inventory control of drugs, the forecast for demand has a close relation with the inventory levels. The exponential smoothing, as the extension of the weighted method of moving average, is practically very useful, for example, for the adjustment of the rate of response to the changes in demand. We have applied the second-order system of exponential smoothing in the forecast of the linear model demand in the inventory control of drugs. “ The sum of the absolute value of the forecast errors” and “the absolute value of the running sum of the forecast errors” were calculated. Then, regarding their ranking as the minus points, the 2 smoothing systems were evaluated by adding up those points. In consequence, it was found out that the first-order system of smoothing is apt to cause delayed response and that the second-order system of exponential smoothing may enable to make more accurate estimation of the expected demand.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"68 1","pages":"134-140"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90475679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1979-11-20DOI: 10.5649/JJPHCS1975.5.130
Maruo Ishibashi, H. Mawatari
Disintegration tests of coated tablets were carried out in immersion fluids of different pH values according to the modified procedure described in the Japanese Pharmacopoeia (J.P.). The apparatus used was also conformed to J. P. Consequently, 134 of 141 samples were completely disintegrated in any of the acidic fluids. But, 5 of them were not always disintegrated in such test fluids, and 2 were disintegrated by the methods other than those described in J. P. The official compendium and package inserts now in use should be supplemented with more data on disintegration.
{"title":"Comparison of Disintegration Time of Coated Tablets in Test Fluids of Different pH Values","authors":"Maruo Ishibashi, H. Mawatari","doi":"10.5649/JJPHCS1975.5.130","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.5.130","url":null,"abstract":"Disintegration tests of coated tablets were carried out in immersion fluids of different pH values according to the modified procedure described in the Japanese Pharmacopoeia (J.P.). The apparatus used was also conformed to J. P. Consequently, 134 of 141 samples were completely disintegrated in any of the acidic fluids. But, 5 of them were not always disintegrated in such test fluids, and 2 were disintegrated by the methods other than those described in J. P. The official compendium and package inserts now in use should be supplemented with more data on disintegration.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"39 1","pages":"130-133"},"PeriodicalIF":0.0,"publicationDate":"1979-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85033852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1976-11-20DOI: 10.5649/JJPHCS1975.2.159
K. Takatori, S. Nakano, T. Hasegawa
Fourteen brands of dextran sulfate sodium (DS-Na) tablets of 11 manufacturers (7 brands in sugar-coated tablet and remaining 7 in film-coated tablet) were tested on their pharmaceutical characteristics, heat resistance, moisture resistance and disintegration. In theheat resistance test, 9 brands out of the 14 showed “good” result, while 11 brands were proved “good” in moisture resistance. In the disintegration test after storage, 11 brands underwent no change.
{"title":"Comparison of Pharmaceutical Properties of Dextran Sulfate Sodium Tablets","authors":"K. Takatori, S. Nakano, T. Hasegawa","doi":"10.5649/JJPHCS1975.2.159","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.2.159","url":null,"abstract":"Fourteen brands of dextran sulfate sodium (DS-Na) tablets of 11 manufacturers (7 brands in sugar-coated tablet and remaining 7 in film-coated tablet) were tested on their pharmaceutical characteristics, heat resistance, moisture resistance and disintegration. In theheat resistance test, 9 brands out of the 14 showed “good” result, while 11 brands were proved “good” in moisture resistance. In the disintegration test after storage, 11 brands underwent no change.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"26 2 1","pages":"159-164"},"PeriodicalIF":0.0,"publicationDate":"1976-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90428998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sumida, K. Wakabayashi, K. Sato, H. Katsuta, Katsuhisa Furuichi
Two kinds of powders with different physical properties were chosen to examine the relations between the angle of repose, dispersibility and the loss in weight on dividing and packaging. The loss in weight on dividing of the two kinds of powders, when mixed, may depend largely on their physical properties. Actually, the relation between dispersibility and the loss in weight, though largely depending on physical properties of powders, generally fluctuated in proportion to the mixing ratio. The angle of repose showed a tendency to fluctuate in proportion to the mixing ratio. But when two kinds of powders with different physical properties are mixed, it is difficult to measure the angle of repose because they separate before measuring. Therefore, it is impossible to observe minutely the relation between the angle of repose and the loss in weight on dividing.
{"title":"Relationship Between the Loss in Weight on Dividing and Dustability or Angle of Repose of Compound Powders","authors":"K. Sumida, K. Wakabayashi, K. Sato, H. Katsuta, Katsuhisa Furuichi","doi":"10.5649/jjphcs1975.2.46","DOIUrl":"https://doi.org/10.5649/jjphcs1975.2.46","url":null,"abstract":"Two kinds of powders with different physical properties were chosen to examine the relations between the angle of repose, dispersibility and the loss in weight on dividing and packaging. The loss in weight on dividing of the two kinds of powders, when mixed, may depend largely on their physical properties. Actually, the relation between dispersibility and the loss in weight, though largely depending on physical properties of powders, generally fluctuated in proportion to the mixing ratio. The angle of repose showed a tendency to fluctuate in proportion to the mixing ratio. But when two kinds of powders with different physical properties are mixed, it is difficult to measure the angle of repose because they separate before measuring. Therefore, it is impossible to observe minutely the relation between the angle of repose and the loss in weight on dividing.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"32 1","pages":"46-50"},"PeriodicalIF":0.0,"publicationDate":"1976-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85454112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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