The effects of age and concurrent administration of antiepileptic drugs on phenobarbital serum concentration/dosage ratio in children were studied. The ratio of serum concentration/dosage for phenobarbital both without and with the concurrent administration of antiepileptic drugs was significantly correlated with the age of patients, and the ratio increased with the increase in the age of children. The ratio of patients who had taken valproate sodium and/or more than two kinds of anti-epileptics with phenobarbital washigher than that of patients had taken phenobarbital alone.Therefore, the patients who are taking valproate sodium and/or more than two kinds of anti-epileptics with phenobarbital is needed careful monitoring of phenobarbital serum concentrations because of their drug interaction.
{"title":"小児におけるフェノバルビタール血中濃度 S/D比と年齢の関係及び併用薬の影響","authors":"栄二 湯川, Yukawa Eiji, Higuchi Shun, 駿 樋口, Ieiri Ichiro, 一郎 家入, Teshima Daisuke, 大輔 手嶋, Nakao Yasushi, 泰史 中尾, 敏信 青山, Aoyama Toshinobu","doi":"10.5649/JJPHCS1975.14.172","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.14.172","url":null,"abstract":"The effects of age and concurrent administration of antiepileptic drugs on phenobarbital serum concentration/dosage ratio in children were studied. The ratio of serum concentration/dosage for phenobarbital both without and with the concurrent administration of antiepileptic drugs was significantly correlated with the age of patients, and the ratio increased with the increase in the age of children. The ratio of patients who had taken valproate sodium and/or more than two kinds of anti-epileptics with phenobarbital washigher than that of patients had taken phenobarbital alone.Therefore, the patients who are taking valproate sodium and/or more than two kinds of anti-epileptics with phenobarbital is needed careful monitoring of phenobarbital serum concentrations because of their drug interaction.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"12 1","pages":"172-177"},"PeriodicalIF":0.0,"publicationDate":"1988-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82579019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1988-02-20DOI: 10.5649/JJPHCS1975.14.66
N. Inotsume, M. Mishima, M. Nakano, Y. Kaneko, Yoshimasa Miyauchi
Bioequivalency of newly formulated digoxin powder containing mainly crystalline lactose, which is expected to improve the fluidity of powder, was compared with that of the previous formula containing non-crystalline lactose.The digoxin concentrations in serum of 8 healthy male volunteers were determined by Stratus Immunoassay System after oral administration of either new or old formulation of digoxin powders in a latin square crossover design.The extent and rate of bioavailability of the both digoxin powders were found to be bioequivalent.It was concluded that both formula had clinically equivalent bioavailability but the power of analysis in this bioequivalency test was lower than the guide-line valve given by the committee on bioequivalency test.
{"title":"Bioequivalence Test of Digoxin Powders Containing a New Formula of Lactose","authors":"N. Inotsume, M. Mishima, M. Nakano, Y. Kaneko, Yoshimasa Miyauchi","doi":"10.5649/JJPHCS1975.14.66","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.14.66","url":null,"abstract":"Bioequivalency of newly formulated digoxin powder containing mainly crystalline lactose, which is expected to improve the fluidity of powder, was compared with that of the previous formula containing non-crystalline lactose.The digoxin concentrations in serum of 8 healthy male volunteers were determined by Stratus Immunoassay System after oral administration of either new or old formulation of digoxin powders in a latin square crossover design.The extent and rate of bioavailability of the both digoxin powders were found to be bioequivalent.It was concluded that both formula had clinically equivalent bioavailability but the power of analysis in this bioequivalency test was lower than the guide-line valve given by the committee on bioequivalency test.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"53 1","pages":"66-69"},"PeriodicalIF":0.0,"publicationDate":"1988-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82945404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1988-01-01DOI: 10.5649/jjphcs1975.14.24
N. Matsumoto, Kazuo Ohsima, Y. Kurosawa
The analytical method for aprotinin preparation has been established using reversed phase high performance liquid chromatography, and the characteristics of the four contaminating unknown compounds in this preparation were studied. Aprotinin and the four contaminants were separated by using C18 column (CHEMCOSORB 5-ODS-H) and 13% acetonitrile containing 0.1 M potassium dihydrogenphosphate adjusted to pH 3.0 with phosphoric acid as a mobile phase, or by using a C4 column (CHEMCOSORB 300-7C4) and 10% acetonitrile solution containing the same phosphate buffer as the mobile phase.Five commercially available aprotinin injection forms were found to be composed of aprotinin and identical ratios of the four contaminants. In addition, the four contaminants had weaker inhibitory activity than aprotinin. These four contaminants were considered to be originated from aprotinin as their amino acid compositions of these contaminants were the same as that of aprotinin. Therefore, the production of these four contaminants may occur through an irreversible or extremely biased equilibrium process.
{"title":"Quality Testing for Aprotinin Preparation by High-Performance Liquid Chromatography","authors":"N. Matsumoto, Kazuo Ohsima, Y. Kurosawa","doi":"10.5649/jjphcs1975.14.24","DOIUrl":"https://doi.org/10.5649/jjphcs1975.14.24","url":null,"abstract":"The analytical method for aprotinin preparation has been established using reversed phase high performance liquid chromatography, and the characteristics of the four contaminating unknown compounds in this preparation were studied. Aprotinin and the four contaminants were separated by using C18 column (CHEMCOSORB 5-ODS-H) and 13% acetonitrile containing 0.1 M potassium dihydrogenphosphate adjusted to pH 3.0 with phosphoric acid as a mobile phase, or by using a C4 column (CHEMCOSORB 300-7C4) and 10% acetonitrile solution containing the same phosphate buffer as the mobile phase.Five commercially available aprotinin injection forms were found to be composed of aprotinin and identical ratios of the four contaminants. In addition, the four contaminants had weaker inhibitory activity than aprotinin. These four contaminants were considered to be originated from aprotinin as their amino acid compositions of these contaminants were the same as that of aprotinin. Therefore, the production of these four contaminants may occur through an irreversible or extremely biased equilibrium process.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"95 1","pages":"24-29"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83701498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1988-01-01DOI: 10.5649/jjphcs1975.14.439
Y. Insemi, Hajime Takeda, Yukiko Shimizu, Yuko Kiyabu
A patient offered that oral administered tablet excreted in stool in the unchanged form. We investigated this film-coated tablet, Perycit® (Niceritrol), by the J.P.XI disintegration test.Although it was broken completely in the J. P. XI first fluid (pH 1.2), it was not broken at all in the J.P.XI second fluid (pH 6.8) or water.We examined its disintegration test in various pH with Mcllvaine buffer solution, and the results were that the time prolonged extremely above pH 5.0.57 kinds of commercial film-coated tablets tested were broken rapidly in the J.P.XI second fluid and water except Perycit®. Perycit® seemed to be used in a peculiar film-coating material and may be not disintegrated in human gastrointestinal fluid because of the resistance of film-coating material to alkali and water.These results suggest that Perycit® should be used carefully to patient with anacidity and such information must be given to users in detail.
{"title":"Examination of Disintegration for Film-coated Niceritrol Tablet Excreted without Disintegration","authors":"Y. Insemi, Hajime Takeda, Yukiko Shimizu, Yuko Kiyabu","doi":"10.5649/jjphcs1975.14.439","DOIUrl":"https://doi.org/10.5649/jjphcs1975.14.439","url":null,"abstract":"A patient offered that oral administered tablet excreted in stool in the unchanged form. We investigated this film-coated tablet, Perycit® (Niceritrol), by the J.P.XI disintegration test.Although it was broken completely in the J. P. XI first fluid (pH 1.2), it was not broken at all in the J.P.XI second fluid (pH 6.8) or water.We examined its disintegration test in various pH with Mcllvaine buffer solution, and the results were that the time prolonged extremely above pH 5.0.57 kinds of commercial film-coated tablets tested were broken rapidly in the J.P.XI second fluid and water except Perycit®. Perycit® seemed to be used in a peculiar film-coating material and may be not disintegrated in human gastrointestinal fluid because of the resistance of film-coating material to alkali and water.These results suggest that Perycit® should be used carefully to patient with anacidity and such information must be given to users in detail.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"38 1","pages":"439-442"},"PeriodicalIF":0.0,"publicationDate":"1988-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85670327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-12-20DOI: 10.5649/JJPHCS1975.13.340
K. Sakurada, S. Ozaki, Akihiko Furugori, K. Sugawara
The stability and the vasoconstrictor effect of fluocinonide in admixtures of fluocinonide ointment with other ointments were studied and the following results were obtained. No change in color on the appearance, in apparent pH and in contents of fluocinonide was observed until 4 weeks after the combination. In admixtures of fluocinonide ointment with ointments used emulsion bases, however, the separation of liquid and the decrease of the release of fluocinonide through the cellulose membrane were observed for 1-4 weeks after the combination.when these admixtures were applied on skin of human, furthermore, a tendency of the decrease of the vasoconstrictor effect was showed with the lapse of time. In conclusion, it is desirable to avoid mixing fluocinonide ointment with other ointments used emulsion bases beforehand and giving patients as admixtures.
{"title":"Stability and Vasoconstrictor Effect of Fluocinonide in Ointment Admixtures","authors":"K. Sakurada, S. Ozaki, Akihiko Furugori, K. Sugawara","doi":"10.5649/JJPHCS1975.13.340","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.13.340","url":null,"abstract":"The stability and the vasoconstrictor effect of fluocinonide in admixtures of fluocinonide ointment with other ointments were studied and the following results were obtained. No change in color on the appearance, in apparent pH and in contents of fluocinonide was observed until 4 weeks after the combination. In admixtures of fluocinonide ointment with ointments used emulsion bases, however, the separation of liquid and the decrease of the release of fluocinonide through the cellulose membrane were observed for 1-4 weeks after the combination.when these admixtures were applied on skin of human, furthermore, a tendency of the decrease of the vasoconstrictor effect was showed with the lapse of time. In conclusion, it is desirable to avoid mixing fluocinonide ointment with other ointments used emulsion bases beforehand and giving patients as admixtures.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"152 1","pages":"340-344"},"PeriodicalIF":0.0,"publicationDate":"1987-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73443329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-12-20DOI: 10.5649/JJPHCS1975.13.366
K. Kawakatsu, Y. Okabe, Toshiya Kino, M. Chikuma
(Received April 30, 1987) We evaluated the particle-enhanced turbidimetric inhibition immunoassay (PETINIA) for the measurement of theophylline in serum. The coefficients of variation in both within-day (n= 10) and between-day (n=10) precision studies were less than 4 %, and the analytical recoveries were 98-103% at the concentrations of 5, 10 and 20 Pg/ml of theophylline. Good correlations were observed among assay results by PETINIA, high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA) for 120 serum specimens cbllected from patients with chronic obstructive pulmonary disease receiving theophylline therapy. The regression lines obtained were : PETINIA =1.034 x HPLC -0.404 (r =0.994, Sy/x=0. 57Pg/ ml), PETINIA =1.037 x FPIA0.539 (r=0.995, Sy/x=0.51pg/m1). The cross reactivity in PETINIA was also studied with 11 compounds structurally related to theophylline. None of these compounds exhibited significant cross reactivity (less than 5 %) except for 1,3-dimethyluric acid (11%). From these results, we could conclude that PETINIA is a useful method for therapeutic monitoring of serum theophylline having good precision and accuracy, and high specificity.
{"title":"Evaluation of Particle-Enhanced Turbidimetric Inhibition Immunoassay for Determination of Theophylline Concentration in Serum","authors":"K. Kawakatsu, Y. Okabe, Toshiya Kino, M. Chikuma","doi":"10.5649/JJPHCS1975.13.366","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.13.366","url":null,"abstract":"(Received April 30, 1987) We evaluated the particle-enhanced turbidimetric inhibition immunoassay (PETINIA) for the measurement of theophylline in serum. The coefficients of variation in both within-day (n= 10) and between-day (n=10) precision studies were less than 4 %, and the analytical recoveries were 98-103% at the concentrations of 5, 10 and 20 Pg/ml of theophylline. Good correlations were observed among assay results by PETINIA, high-performance liquid chromatography (HPLC) and fluorescence polarization immunoassay (FPIA) for 120 serum specimens cbllected from patients with chronic obstructive pulmonary disease receiving theophylline therapy. The regression lines obtained were : PETINIA =1.034 x HPLC -0.404 (r =0.994, Sy/x=0. 57Pg/ ml), PETINIA =1.037 x FPIA0.539 (r=0.995, Sy/x=0.51pg/m1). The cross reactivity in PETINIA was also studied with 11 compounds structurally related to theophylline. None of these compounds exhibited significant cross reactivity (less than 5 %) except for 1,3-dimethyluric acid (11%). From these results, we could conclude that PETINIA is a useful method for therapeutic monitoring of serum theophylline having good precision and accuracy, and high specificity.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"147 1","pages":"366-372"},"PeriodicalIF":0.0,"publicationDate":"1987-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91177876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-08-20DOI: 10.5649/JJPHCS1975.13.216
Hideo Adachi, Kazuo Oshima, Y. Kurosawa
{"title":"混合軟膏中のハイドロコルチゾン-17-ブチレートの安定性","authors":"Hideo Adachi, Kazuo Oshima, Y. Kurosawa","doi":"10.5649/JJPHCS1975.13.216","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.13.216","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"5 1","pages":"216-220"},"PeriodicalIF":0.0,"publicationDate":"1987-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74025628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-06-20DOI: 10.5649/JJPHCS1975.13.125
敏信 青山, 栄二 湯川, 駿 樋口, 泰史 中尾, 正義 堀岡
In an attempt to evaluate the reliability of apoenzyme reactivation immunoassay system (ARIS) method, phenobarbital (PB) and phenytoin (PHT) concentrations in patient's serum were measured by ARIS method, and were compared with those obtained by fluorescence polarization immunoassay (FPIA) method and enzyme multiplied immunoassay (EMIT) method.The within-run precision of ARIS method was 2.56-5.26% as the coefficient of variation (C. V.). The C. V. value of between-run precision was less than 6%. There were significant correlations between the serum concentrations determined by ARIS method and each method (FPIA; EMIT). The interference from hemoglobin, bilirubin, ascorbic acid, flavin adenine dinucleotide (FAD) and cross-reacting substances was also investigated and discussed.ARIS method was found to be reliable, simple and rapid one. Therefore, ARIS method seemed to be a useful technique for the rapid determination of drug concentration.
{"title":"抗てんかん薬の血中濃度測定におけるApoenzyme Reactivation Immunoassay System (ARIS) 法の信頼性の検討","authors":"敏信 青山, 栄二 湯川, 駿 樋口, 泰史 中尾, 正義 堀岡","doi":"10.5649/JJPHCS1975.13.125","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.13.125","url":null,"abstract":"In an attempt to evaluate the reliability of apoenzyme reactivation immunoassay system (ARIS) method, phenobarbital (PB) and phenytoin (PHT) concentrations in patient's serum were measured by ARIS method, and were compared with those obtained by fluorescence polarization immunoassay (FPIA) method and enzyme multiplied immunoassay (EMIT) method.The within-run precision of ARIS method was 2.56-5.26% as the coefficient of variation (C. V.). The C. V. value of between-run precision was less than 6%. There were significant correlations between the serum concentrations determined by ARIS method and each method (FPIA; EMIT). The interference from hemoglobin, bilirubin, ascorbic acid, flavin adenine dinucleotide (FAD) and cross-reacting substances was also investigated and discussed.ARIS method was found to be reliable, simple and rapid one. Therefore, ARIS method seemed to be a useful technique for the rapid determination of drug concentration.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"14 11 1","pages":"125-131"},"PeriodicalIF":0.0,"publicationDate":"1987-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89585062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1987-01-01DOI: 10.5649/jjphcs1975.13.226
Mikio Nishikawa, Kazuichi Suzuki, S. Kachi, I. Kawakage, K. Fujii, H. Matsuda, K. Kanai
The concentration of benzyl alcohol (BA) in the blood of the patients after the intravariceal injection of ethanolamine oleate (EO) with meglumine amidotrizoate (EO-MA) for endoscopic sclerotherapy of esophageal varices was determined by GLC method. BA appeared in the peripheral blood immediately after the interavariceal injection of EO-MA, therefore it was found that the leak of BA from the varix occurred very early. But BA disappeared rapidly from the blood (t1/2= 10 minutes). The hemolysis after the intravariceal injection had no relation to the concentration of BA in the blood.The actions of BA and EO on erythrocytes were examined in vitro, and the hemolyzing effect of EO was much stronger than that of BA. From these results, it is thought that the effect of BA on the hemolysis after the intravariceal injection of EO-MA is only a little and the hemolysis probably results from EO.
{"title":"The concentration of benzyl alcohol in the blood after the injection of ethanolamine oleate.","authors":"Mikio Nishikawa, Kazuichi Suzuki, S. Kachi, I. Kawakage, K. Fujii, H. Matsuda, K. Kanai","doi":"10.5649/jjphcs1975.13.226","DOIUrl":"https://doi.org/10.5649/jjphcs1975.13.226","url":null,"abstract":"The concentration of benzyl alcohol (BA) in the blood of the patients after the intravariceal injection of ethanolamine oleate (EO) with meglumine amidotrizoate (EO-MA) for endoscopic sclerotherapy of esophageal varices was determined by GLC method. BA appeared in the peripheral blood immediately after the interavariceal injection of EO-MA, therefore it was found that the leak of BA from the varix occurred very early. But BA disappeared rapidly from the blood (t1/2= 10 minutes). The hemolysis after the intravariceal injection had no relation to the concentration of BA in the blood.The actions of BA and EO on erythrocytes were examined in vitro, and the hemolyzing effect of EO was much stronger than that of BA. From these results, it is thought that the effect of BA on the hemolysis after the intravariceal injection of EO-MA is only a little and the hemolysis probably results from EO.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"51 1","pages":"226-230"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85816675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-10-20DOI: 10.5649/JJPHCS1975.11.414
A. Takayama, T. Koshikawa, I. Saito, K. Okumura, R. Hori, I. Johno, S. Kitazawa
The effect of storage condition and the quality of wrapping paper on the moisture protection of pharmaceutical preparations were investigated using a couple of pulverized hygroscopic pharmaceuticals and a few powder preparations having different critical relative humidity. Sodium valproate or potassium L-aspartate tablet was pulverized. Powder preparations used were potato starch, lactose, sodium chloride and fructose. 9 different wrapping papers having various grades of moisture permeability were adopted. The results of the study were as follows:1) The moisture permeation of wrapped powder preparations is affected by storage conditions. 2) Amount of absorbed moisture decreased when wrapping papers, with low moisture permeability were used; therefore, it became clear that the selection of suitable wrapping papers is important to protect powder preparations against the moisture permeation.
{"title":"Moisture Protection for Powder Preparations ; Effect of Storage Conditions and the Quality of Wrapping Paper","authors":"A. Takayama, T. Koshikawa, I. Saito, K. Okumura, R. Hori, I. Johno, S. Kitazawa","doi":"10.5649/JJPHCS1975.11.414","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.11.414","url":null,"abstract":"The effect of storage condition and the quality of wrapping paper on the moisture protection of pharmaceutical preparations were investigated using a couple of pulverized hygroscopic pharmaceuticals and a few powder preparations having different critical relative humidity. Sodium valproate or potassium L-aspartate tablet was pulverized. Powder preparations used were potato starch, lactose, sodium chloride and fructose. 9 different wrapping papers having various grades of moisture permeability were adopted. The results of the study were as follows:1) The moisture permeation of wrapped powder preparations is affected by storage conditions. 2) Amount of absorbed moisture decreased when wrapping papers, with low moisture permeability were used; therefore, it became clear that the selection of suitable wrapping papers is important to protect powder preparations against the moisture permeation.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"83 1","pages":"414-418"},"PeriodicalIF":0.0,"publicationDate":"1985-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79985618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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