Pub Date : 1985-06-20DOI: 10.5649/JJPHCS1975.11.276
Y. Ueno, Keiko Tanaka, Yuriko Kondo
Therapeutic drug monitoring (TDM) has been widely practiced in the clinical field. TDM requires the concentration of a drug in a steady state. In order to obtain reliable results of TDM, patients should take medicine according to physician's direction. We have studied the factors which have effect on patient's compliance by interviewing 640 patients. As a result, the average ratio of patient's compliance was about 40%. From this study 3 factors which increase patient's compliance and 4 factors which have little effect have been selected, as follows:A) Factors which increse patient's compliance: 1) Patient's recognition of the importance of medication. 2) Patient's refraining from discretion in taking. medicine. 3) Keeping exactly the frequency of daily medication.B) Factors which have little effect: 1) Frequency of daily medication. 2) Period of medication. 3) Kind of medicine. 4) Concern about the adverse effect of medicine.In addition, the ratio of patient's compliance varied with the kind of disease. For example, the ratio was high among tuberculous patients and low among hypertensive patients.
{"title":"Factors Affecting Patient's Compliance","authors":"Y. Ueno, Keiko Tanaka, Yuriko Kondo","doi":"10.5649/JJPHCS1975.11.276","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.11.276","url":null,"abstract":"Therapeutic drug monitoring (TDM) has been widely practiced in the clinical field. TDM requires the concentration of a drug in a steady state. In order to obtain reliable results of TDM, patients should take medicine according to physician's direction. We have studied the factors which have effect on patient's compliance by interviewing 640 patients. As a result, the average ratio of patient's compliance was about 40%. From this study 3 factors which increase patient's compliance and 4 factors which have little effect have been selected, as follows:A) Factors which increse patient's compliance: 1) Patient's recognition of the importance of medication. 2) Patient's refraining from discretion in taking. medicine. 3) Keeping exactly the frequency of daily medication.B) Factors which have little effect: 1) Frequency of daily medication. 2) Period of medication. 3) Kind of medicine. 4) Concern about the adverse effect of medicine.In addition, the ratio of patient's compliance varied with the kind of disease. For example, the ratio was high among tuberculous patients and low among hypertensive patients.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"56 1","pages":"276-283"},"PeriodicalIF":0.0,"publicationDate":"1985-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77858301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1985-01-01DOI: 10.5649/jjphcs1975.11.481
O. Ueno, H. Kodama, Masako Higashi, K. Nakayama, O. Fukushima, S. Hidaka, H. Nagakura, Hakaru Seo, Tomohide Maeda, T. Hashimoto, M. Tsuruoka
Recently, transfiguration of infections has been caused by remarkable increase in the amount of antibiotics. We investigated the amount of use and combination of antibiotics during June of 1981, 1982, 1983 and 1984 at our hospital. The results were as follows:1) The total amount of antibiotics use decreased annually. 2) The amount of penicillins, especially carbenicillin and sulbenicillin, decreased remarkably. 3) Of the total combinations, 2-drug combinations occupied 75%-85%. 4) Combination of cephalosporins, especially those of the third generation, and aminoglycosides occurred in the largest number.
{"title":"Situation of Antibiotic Use at Miyazaki Medical College Hospital","authors":"O. Ueno, H. Kodama, Masako Higashi, K. Nakayama, O. Fukushima, S. Hidaka, H. Nagakura, Hakaru Seo, Tomohide Maeda, T. Hashimoto, M. Tsuruoka","doi":"10.5649/jjphcs1975.11.481","DOIUrl":"https://doi.org/10.5649/jjphcs1975.11.481","url":null,"abstract":"Recently, transfiguration of infections has been caused by remarkable increase in the amount of antibiotics. We investigated the amount of use and combination of antibiotics during June of 1981, 1982, 1983 and 1984 at our hospital. The results were as follows:1) The total amount of antibiotics use decreased annually. 2) The amount of penicillins, especially carbenicillin and sulbenicillin, decreased remarkably. 3) Of the total combinations, 2-drug combinations occupied 75%-85%. 4) Combination of cephalosporins, especially those of the third generation, and aminoglycosides occurred in the largest number.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"186 ","pages":"481-487"},"PeriodicalIF":0.0,"publicationDate":"1985-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91549721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-06-20DOI: 10.5649/JJPHCS1975.10.155
S. Hayata, S. Nomura, T. Hitoshi, M. Ota, T. Horikoshi, Tetsuro Tanaka, Y. Hiyoshi
{"title":"Pharmacokinetics and Toxicity of High-Dose Methotrexate Therapy in Children","authors":"S. Hayata, S. Nomura, T. Hitoshi, M. Ota, T. Horikoshi, Tetsuro Tanaka, Y. Hiyoshi","doi":"10.5649/JJPHCS1975.10.155","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.10.155","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"608 1","pages":"155-159"},"PeriodicalIF":0.0,"publicationDate":"1984-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77489714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-06-20DOI: 10.5649/JJPHCS1975.10.171
T. Fujii, Y. Arai, A. Kubota, K. Togawa, N. Mizushima, I. Mikuni
Stability on preservation of Ketotifen Eye Drops prepared in our hospital for treatment of conjunctivitis due to Japanese cedar pollinosis was examined. The suitability of its heat sterilization was also studied. After storing for 3 months at room temperature or 6 months in a cold place, no changes were observed in appearance and physical properties of the solution. The rate of residual Ketotifen was more than 90%. After sterilization at 105°C for 15 minutes, coloration, .decrease in content, decomposed products were observed, and sterilization by heating seemed impossible. However, it is considered that Ketotifen Eye Drops be useful if it is prepared in the germ-free conditions and preserved in a cold place.
{"title":"Quality Test of Ketotifen Eye Drops Prepared in Hospital : (2) The Irritability Test","authors":"T. Fujii, Y. Arai, A. Kubota, K. Togawa, N. Mizushima, I. Mikuni","doi":"10.5649/JJPHCS1975.10.171","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.10.171","url":null,"abstract":"Stability on preservation of Ketotifen Eye Drops prepared in our hospital for treatment of conjunctivitis due to Japanese cedar pollinosis was examined. The suitability of its heat sterilization was also studied. After storing for 3 months at room temperature or 6 months in a cold place, no changes were observed in appearance and physical properties of the solution. The rate of residual Ketotifen was more than 90%. After sterilization at 105°C for 15 minutes, coloration, .decrease in content, decomposed products were observed, and sterilization by heating seemed impossible. However, it is considered that Ketotifen Eye Drops be useful if it is prepared in the germ-free conditions and preserved in a cold place.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"109 1","pages":"177-181"},"PeriodicalIF":0.0,"publicationDate":"1984-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80947688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1984-01-01DOI: 10.5649/jjphcs1975.10.375
N. Hosoda, N. Yasuda, T. Senda, Y. Obata
In an attempt to improve the anticonvulsant therapy, the serum concentration of phenobarbital (PB), valproic acid (VPA) and phenytoin (PHT) was assessed in 62 pediatric patients who were treated with these drugs administered alone or concomitantly. The serum concentration of PB was higher when administered concomitantly with PHT or VPA as compared with that when administered alone. Conversely, the serum concentration of VPA tended to be lowered when administered in conjunction with PB. Good correlations were demonstrated between the determined concentration of PB or VPA and those predicted by the pharmacokinetic calculation.A case report was described referring to the therapeutic schedule of PB and PHT, their serum concentrations, occurrence of adverse effects and the symptoms. It was indicated that determination of serum concentration of administered anticonvulsants may prevent the possible adverse effects and be useful for improving the therapeutic schedule.
{"title":"Regulation of Anticonvulsant Therapeutic Schedule by Serum Concentrations","authors":"N. Hosoda, N. Yasuda, T. Senda, Y. Obata","doi":"10.5649/jjphcs1975.10.375","DOIUrl":"https://doi.org/10.5649/jjphcs1975.10.375","url":null,"abstract":"In an attempt to improve the anticonvulsant therapy, the serum concentration of phenobarbital (PB), valproic acid (VPA) and phenytoin (PHT) was assessed in 62 pediatric patients who were treated with these drugs administered alone or concomitantly. The serum concentration of PB was higher when administered concomitantly with PHT or VPA as compared with that when administered alone. Conversely, the serum concentration of VPA tended to be lowered when administered in conjunction with PB. Good correlations were demonstrated between the determined concentration of PB or VPA and those predicted by the pharmacokinetic calculation.A case report was described referring to the therapeutic schedule of PB and PHT, their serum concentrations, occurrence of adverse effects and the symptoms. It was indicated that determination of serum concentration of administered anticonvulsants may prevent the possible adverse effects and be useful for improving the therapeutic schedule.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"78 1","pages":"375-378"},"PeriodicalIF":0.0,"publicationDate":"1984-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75404242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1983-10-20DOI: 10.5649/JJPHCS1975.9.384
M. Hirahara, Masafumi Ogawa, M. Shigematsu, K. Nagayama, A. Satake, K. Hori, Itsumi Miyabe
(Received May 20, 1983) A high performance liquid chromatograph (HPLC) was used for the quality test of Ubidecarenone (CoQ10) products. CoQ10 products were exposed to light under 2000 lux for 29 days, and their stability to light was studied with HPLC. The results were as follows: 1) Good separation of CoQ10. CoQ9 and UC9 was achieved with HPLC. 2) The amount of CoQ10 in granules and fine granules packed with Pile Packer Film was between 11% and 18% after 29day exposure to light, whereas CoQ10 in granules in lightshielded package and that in raw material powder packed with pile packer Film were 74% and 90%, respectively. 3) The main decomposition substance of the granules, the fine granules and raw material powder showed that the relative retention to CoQ10 was 0.49. Keywordsubidecarenone; ubichromenol9; quality test; stability to light
{"title":"Stability and Decomposition Substances of Ubidecarenone Granules and Fine Granules on Exposure to Light","authors":"M. Hirahara, Masafumi Ogawa, M. Shigematsu, K. Nagayama, A. Satake, K. Hori, Itsumi Miyabe","doi":"10.5649/JJPHCS1975.9.384","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.9.384","url":null,"abstract":"(Received May 20, 1983) A high performance liquid chromatograph (HPLC) was used for the quality test of Ubidecarenone (CoQ10) products. CoQ10 products were exposed to light under 2000 lux for 29 days, and their stability to light was studied with HPLC. The results were as follows: 1) Good separation of CoQ10. CoQ9 and UC9 was achieved with HPLC. 2) The amount of CoQ10 in granules and fine granules packed with Pile Packer Film was between 11% and 18% after 29day exposure to light, whereas CoQ10 in granules in lightshielded package and that in raw material powder packed with pile packer Film were 74% and 90%, respectively. 3) The main decomposition substance of the granules, the fine granules and raw material powder showed that the relative retention to CoQ10 was 0.49. Keywordsubidecarenone; ubichromenol9; quality test; stability to light","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"29 1","pages":"384-388"},"PeriodicalIF":0.0,"publicationDate":"1983-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85170712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Tsuchiya, T. Nakano, Hideki Harasawa, Fumiko Okabe, K. Tsuchiya, T. Sawai, A. Nishitani, Y. Iwasaki
{"title":"Pharmaceutical Study of Enzyme Preparations","authors":"M. Tsuchiya, T. Nakano, Hideki Harasawa, Fumiko Okabe, K. Tsuchiya, T. Sawai, A. Nishitani, Y. Iwasaki","doi":"10.5649/JJPHCS1975.9.26","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.9.26","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"67 1","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"1983-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80953694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-10-20DOI: 10.5649/JJPHCS1975.8.288
S. Sakurai, S. Yakou, M. Sugihara, T. Ohkawa, E. Tazaki, K. Fukumuro
Effect of various bases on rabbit rectal absorption and in vitro release from suppositories containing pentazocine were investigated. Analgesic effect of pentazocine suppository on cancerous pain was also examined. Rectal suppositories were made with glycerogelatin (Gly), polyethylene glycol (PEG) and oleaginous (Witep) bases. The rate of release of pentazocine from a suppository was higher in the order of PEG, Gly and Witep bases. There was no significant difference between PEG base and Witep base in absorption of pentazocine from rabbit rectum, while Gly base gave the lowest absorption. Among 15 patients which received the administration of pentazocine suppository, the agent proved extremely useful, useful and useless in 2, 11 and 2 cases, respectively. Side effect was not observed.
{"title":"Effect of Various Bases on Rabbit Rectal Absorption and Clinical Evaluation of Pentazocine Suppository","authors":"S. Sakurai, S. Yakou, M. Sugihara, T. Ohkawa, E. Tazaki, K. Fukumuro","doi":"10.5649/JJPHCS1975.8.288","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.8.288","url":null,"abstract":"Effect of various bases on rabbit rectal absorption and in vitro release from suppositories containing pentazocine were investigated. Analgesic effect of pentazocine suppository on cancerous pain was also examined. Rectal suppositories were made with glycerogelatin (Gly), polyethylene glycol (PEG) and oleaginous (Witep) bases. The rate of release of pentazocine from a suppository was higher in the order of PEG, Gly and Witep bases. There was no significant difference between PEG base and Witep base in absorption of pentazocine from rabbit rectum, while Gly base gave the lowest absorption. Among 15 patients which received the administration of pentazocine suppository, the agent proved extremely useful, useful and useless in 2, 11 and 2 cases, respectively. Side effect was not observed.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"45 1","pages":"288-293"},"PeriodicalIF":0.0,"publicationDate":"1982-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76579471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-08-20DOI: 10.5649/JJPHCS1975.8.229
Y. Insemi, S. Mori, Youko Muroda
There are two kinds of dispensed medicines which remain in hospital pharmacy not received by outpatients. One of them is the temporary unreceived medicines that patients did not take in the office hour but received later, and the other is the medicines that were not finally received. The latter was examined mainly. When the electric number indicative system was installed in the Public Ishikawa Central Hospital, the unreceived medicines decreased significantly. The, decrease was remarkable at the departments with small number of prescriptions. It has been reported that waiting time or number of accepted prescriptions is correlated with number of unreceived medicines. But this correlation is observed only in temporary unreceived medicines, and no correlation between finally unreceived medicines and number of prescriptions was observed.
{"title":"Electric Number Indicative System of Decrease in Unreceived Medicines","authors":"Y. Insemi, S. Mori, Youko Muroda","doi":"10.5649/JJPHCS1975.8.229","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.8.229","url":null,"abstract":"There are two kinds of dispensed medicines which remain in hospital pharmacy not received by outpatients. One of them is the temporary unreceived medicines that patients did not take in the office hour but received later, and the other is the medicines that were not finally received. The latter was examined mainly. When the electric number indicative system was installed in the Public Ishikawa Central Hospital, the unreceived medicines decreased significantly. The, decrease was remarkable at the departments with small number of prescriptions. It has been reported that waiting time or number of accepted prescriptions is correlated with number of unreceived medicines. But this correlation is observed only in temporary unreceived medicines, and no correlation between finally unreceived medicines and number of prescriptions was observed.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"62 1","pages":"229-233"},"PeriodicalIF":0.0,"publicationDate":"1982-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84734096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1982-08-20DOI: 10.5649/JJPHCS1975.8.222
S. Yasuda, M. Muto, Yoko Nakaoka, Tomoko Yamashita, Yoshitaka Okamura, T. Kashiwagi, S. Naito
{"title":"Case Studies with Brompton Mixture","authors":"S. Yasuda, M. Muto, Yoko Nakaoka, Tomoko Yamashita, Yoshitaka Okamura, T. Kashiwagi, S. Naito","doi":"10.5649/JJPHCS1975.8.222","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.8.222","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"8 1","pages":"222-228"},"PeriodicalIF":0.0,"publicationDate":"1982-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86329049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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