Pub Date : 1997-08-10DOI: 10.5649/JJPHCS1975.23.364
Hitoshi Sato, T. Yamanouchi, F. Kobayashi, Satomi Sato, I. Horikoshi
{"title":"Usage and Evaluation of a Program to Produce Drug Compliance Instruction-Sheets, MacAdvice","authors":"Hitoshi Sato, T. Yamanouchi, F. Kobayashi, Satomi Sato, I. Horikoshi","doi":"10.5649/JJPHCS1975.23.364","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.23.364","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"30 1","pages":"364-374"},"PeriodicalIF":0.0,"publicationDate":"1997-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78397295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-06-10DOI: 10.5649/JJPHCS1975.23.202
S. Ohshiro, N. Hokama, N. Hobara
The povidone-iodine contents in liquid and ointment were determined using high-performance liquid chromatography (HPLC). The chromatograph equipped reversed phase ODS column and detector was set at 355 nm. The flow rate of the mobile phase of methanol: water (7: 3) containing 1% KI was 1.0ml/min.The retention time of povidone-iodine was 3.9 min. When this HPLC was applied to the povidone-iodine preparations (gurgle and solution) on the commercial market, the povidoneiodinecontents were found to comprise more than 95%. In the povidone-iodine sugar ointment, which was prepared in the hospital pharmacy, admixed with lysozyme chloride ointment, the iodine contents by this HPLC had a good correlation with the available iodine contents by titration (r=0.9999). Furthermore, this method could also be applied to povidoneiodine in the organic solution after extracting the povidone-iodine sugar ointment admixed with lysozyme chloride ointment.
{"title":"Determination of the Povidone-Iodine Contents by High-performance Liquid Chromatography","authors":"S. Ohshiro, N. Hokama, N. Hobara","doi":"10.5649/JJPHCS1975.23.202","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.23.202","url":null,"abstract":"The povidone-iodine contents in liquid and ointment were determined using high-performance liquid chromatography (HPLC). The chromatograph equipped reversed phase ODS column and detector was set at 355 nm. The flow rate of the mobile phase of methanol: water (7: 3) containing 1% KI was 1.0ml/min.The retention time of povidone-iodine was 3.9 min. When this HPLC was applied to the povidone-iodine preparations (gurgle and solution) on the commercial market, the povidoneiodinecontents were found to comprise more than 95%. In the povidone-iodine sugar ointment, which was prepared in the hospital pharmacy, admixed with lysozyme chloride ointment, the iodine contents by this HPLC had a good correlation with the available iodine contents by titration (r=0.9999). Furthermore, this method could also be applied to povidoneiodine in the organic solution after extracting the povidone-iodine sugar ointment admixed with lysozyme chloride ointment.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"13 1","pages":"202-206"},"PeriodicalIF":0.0,"publicationDate":"1997-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78833270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-06-10DOI: 10.5649/jjphcs1975.23.225
一覚 杉山, 淳一 高橋, 井手上 寿美佳, 幸恵 金子, 富夫 松本, 守 建部
By comparing the usual method of measuring medication dosage in medical cups in our hospital (A packages) with newly developed one dose packages (B, C packages) the stability of the ingredients, the sterility of the material, and the accuracy of the correctness of the measuring the samples, we assessed the usefulness of one dose packages of preservativefree 0.125% tyloxapol solutions for the administration of oral medications. The results were as follows: 1) pH tended to rise in A as the strage temperature increased but was stable in both B and C. No changes in the external appearance were detectable in any of them. 2) No microbial contamination was found in any of the packages, A, B or C. 3) The measuring accuracy was better in B and C than in A. Thus, the one dose packages appeared to be more useful than the usual method of measuring drugs using medical cups as a method by which 0.125% tyloxapol solutions for inhalations can be used safely and conveniently even when supplied to patients.
{"title":"保存剤を含有していない0.125%チロキサポール吸入液における一回量包装の有用性","authors":"一覚 杉山, 淳一 高橋, 井手上 寿美佳, 幸恵 金子, 富夫 松本, 守 建部","doi":"10.5649/jjphcs1975.23.225","DOIUrl":"https://doi.org/10.5649/jjphcs1975.23.225","url":null,"abstract":"By comparing the usual method of measuring medication dosage in medical cups in our hospital (A packages) with newly developed one dose packages (B, C packages) the stability of the ingredients, the sterility of the material, and the accuracy of the correctness of the measuring the samples, we assessed the usefulness of one dose packages of preservativefree 0.125% tyloxapol solutions for the administration of oral medications. The results were as follows: 1) pH tended to rise in A as the strage temperature increased but was stable in both B and C. No changes in the external appearance were detectable in any of them. 2) No microbial contamination was found in any of the packages, A, B or C. 3) The measuring accuracy was better in B and C than in A. Thus, the one dose packages appeared to be more useful than the usual method of measuring drugs using medical cups as a method by which 0.125% tyloxapol solutions for inhalations can be used safely and conveniently even when supplied to patients.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"44 1","pages":"225-230"},"PeriodicalIF":0.0,"publicationDate":"1997-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80251038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-06-10DOI: 10.5649/JJPHCS1975.23.219
義輝 本田, 眞汎 中野
The adsorption characteristics of various adsorbates by spherical charcoal (Kremezin ®) were studied in vitro and then compared with those of powdered medical charcoal. Medical charcoal adsorbs substances with molecular weights ranging from several hundred daltons to several thousand daltons. Kremezin, however, adsorbs only low molecular weight substances with molecular weights of up to several hundred daltons. Therefore, the adsorption selectivity of Kremezin, which is related to the molecular weight of adsorbate, seemed to contribute to the specific pharmacological action of this drug under clinical conditions. In batch adsorption tests for various amines, amino acids and organic acids with molecular weightsof from 45 to 251, both adsorbents showed similar behaviors. An increase in the size of the adsorbate molecule enhanced the degree of adsorption, especially in compounds that are analogs. The molecular structure also seemed to be an important factor in the adsorption phenomena; an aromatic ring tended to increase the adsobability while the amino group, carboxyl group and hydroxyl group all showed a decrease in adsorbability.
{"title":"球形吸着炭 (クレメジン原体) の吸着特性に関する検討","authors":"義輝 本田, 眞汎 中野","doi":"10.5649/JJPHCS1975.23.219","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.23.219","url":null,"abstract":"The adsorption characteristics of various adsorbates by spherical charcoal (Kremezin ®) were studied in vitro and then compared with those of powdered medical charcoal. Medical charcoal adsorbs substances with molecular weights ranging from several hundred daltons to several thousand daltons. Kremezin, however, adsorbs only low molecular weight substances with molecular weights of up to several hundred daltons. Therefore, the adsorption selectivity of Kremezin, which is related to the molecular weight of adsorbate, seemed to contribute to the specific pharmacological action of this drug under clinical conditions. In batch adsorption tests for various amines, amino acids and organic acids with molecular weightsof from 45 to 251, both adsorbents showed similar behaviors. An increase in the size of the adsorbate molecule enhanced the degree of adsorption, especially in compounds that are analogs. The molecular structure also seemed to be an important factor in the adsorption phenomena; an aromatic ring tended to increase the adsobability while the amino group, carboxyl group and hydroxyl group all showed a decrease in adsorbability.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"43 1","pages":"219-224"},"PeriodicalIF":0.0,"publicationDate":"1997-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79080772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-04-10DOI: 10.5649/JJPHCS1975.23.175
喜紀 寒河江, 昭子 富野, 敏夫 鈴木, 真治 桑原, 多 楠木
A hospital formulary designed for desk top publising (DTP) was published according to the online database system UMIN. In addition to the revision of the textual content, some illustrations and drawings were also inserted in the previous format of our formulary and the publication of the DTP-directed formulary was established in this edition. The database according to this new system at our hospital which has been maintained using a relational database software, was found to be useful for developing additional materials, such as worksheets as well as for insertings structural drawing objects on the drug tables each time. Using the local network system (LAN) by the Windows NT Server, it was possible to perform benefitial data conversions between different OS which thus led to the effective edition of our work. Electric publication of the formurary is suggested to be an excellent method provide the most up-to-date contents of all drug information and to satisfy the need to constantly update the informationl contents.
根据联机数据库系统UMIN，设计了一套用于桌面出版的医院处方集。除了对文本内容进行修订外，还在我们以前的配方集格式中插入了一些插图和图纸，并在这一版本中建立了dtp指导的配方集的出版。根据我们医院的新系统，数据库一直使用关系数据库软件进行维护，发现对于开发额外的材料很有用，例如工作表，以及每次在药物表上插入结构图对象。使用Windows NT Server的本地网络系统(LAN)，可以在不同的操作系统之间进行有益的数据转换，从而导致我们工作的有效版本。电子制版是一种很好的方法，可以提供所有药品信息的最新内容，满足信息内容不断更新的需要。
{"title":"医薬品データベースよりDesk Top Publishing (DTP) を指向した院内医薬品集の試み (2)","authors":"喜紀 寒河江, 昭子 富野, 敏夫 鈴木, 真治 桑原, 多 楠木","doi":"10.5649/JJPHCS1975.23.175","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.23.175","url":null,"abstract":"A hospital formulary designed for desk top publising (DTP) was published according to the online database system UMIN. In addition to the revision of the textual content, some illustrations and drawings were also inserted in the previous format of our formulary and the publication of the DTP-directed formulary was established in this edition. The database according to this new system at our hospital which has been maintained using a relational database software, was found to be useful for developing additional materials, such as worksheets as well as for insertings structural drawing objects on the drug tables each time. Using the local network system (LAN) by the Windows NT Server, it was possible to perform benefitial data conversions between different OS which thus led to the effective edition of our work. Electric publication of the formurary is suggested to be an excellent method provide the most up-to-date contents of all drug information and to satisfy the need to constantly update the informationl contents.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"237 1","pages":"175-184"},"PeriodicalIF":0.0,"publicationDate":"1997-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89072659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1997-02-10DOI: 10.5649/JJPHCS1975.23.36
N. Morikawa, K. Ikawa, Taturo Izumi, M. Takeyama
We discuss the correlation between plasma concentration and clinical dose of Clonazepam (CZP) combined with other anticonvulsants in epileptic children. The plasma concentrations were measured in 610 samples from 141 children (73 males and 68 females) by HPLC method. We found that the clinical doses of CZP in our hospital were lower than those directed in “Goodman and Gilman's The Pharmacological Basis of Therapeutics” and in “United States Pharmacopoeia Dispensing Information”, and that therefore the plasma concentrations were distributed at the low range correspondingly with doses. A correlation between plasma concentration and clinical doses of CZP was observed and the relationship depended on sex and age of the patients. The plasma concentration of CZP in the older group (over 11 years old) was higher than that in the younger group (from 0 to 10 years old) and that in the male group was higher than that in the female group.We surveyed the relationship between the plasma concentration and dose of CZP in two patients over the longterm. The results indicated the necessity for frequent therapeutic drug monitoring of CZP over the longterm at the changes of dose and patient weight.
我们讨论氯硝西泮(CZP)与其他抗惊厥药物在癫痫患儿中的血药浓度与临床剂量的关系。采用高效液相色谱法测定141例儿童(男73例，女68例)610份血药浓度。我们发现本院CZP临床剂量低于《Goodman and Gilman’s the pharmacology Basis of Therapeutics》和《美国药典配药信息》中所规定的剂量，因此血药浓度随剂量呈相应的低范围分布。观察到CZP的血药浓度与临床剂量之间存在相关性，且相关性与患者的性别和年龄有关。老年组(11岁以上)血浆CZP浓度高于年轻组(0 ~ 10岁)，男性组高于女性组。我们调查了两名患者长期血浆浓度和剂量之间的关系。结果表明，有必要在剂量和体重变化的情况下长期监测CZP的治疗药物。
{"title":"Plasma Concentrations of Clonazepam Therapy in Epileptic Children","authors":"N. Morikawa, K. Ikawa, Taturo Izumi, M. Takeyama","doi":"10.5649/JJPHCS1975.23.36","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.23.36","url":null,"abstract":"We discuss the correlation between plasma concentration and clinical dose of Clonazepam (CZP) combined with other anticonvulsants in epileptic children. The plasma concentrations were measured in 610 samples from 141 children (73 males and 68 females) by HPLC method. We found that the clinical doses of CZP in our hospital were lower than those directed in “Goodman and Gilman's The Pharmacological Basis of Therapeutics” and in “United States Pharmacopoeia Dispensing Information”, and that therefore the plasma concentrations were distributed at the low range correspondingly with doses. A correlation between plasma concentration and clinical doses of CZP was observed and the relationship depended on sex and age of the patients. The plasma concentration of CZP in the older group (over 11 years old) was higher than that in the younger group (from 0 to 10 years old) and that in the male group was higher than that in the female group.We surveyed the relationship between the plasma concentration and dose of CZP in two patients over the longterm. The results indicated the necessity for frequent therapeutic drug monitoring of CZP over the longterm at the changes of dose and patient weight.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"21 1","pages":"36-42"},"PeriodicalIF":0.0,"publicationDate":"1997-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90580878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-06-10DOI: 10.5649/JJPHCS1975.22.305
O. Fujishita, K. Kuroda, Y. Nakao, Y. Natori, M. Fukui, R. Oishi
Two concentrated electrolyte injections (solution A and B) were used for the rapid and easy preparation of artificial cerebrospinal fluid (ACF). Solution A (10 ml) included Na, K, Mg, Ca, Cl, lactate, and glucose while solution B (20 ml) was composed of KH2 PO4 and NaHCO3. Solution A was first added to 0, 9% NaCl in jection (515 ml) maintained in a soft plastic bag followed by solution B. Notably, the prepared ACF had particulate matter counts far less than the Japanese pharmacopoeia (JP) and United States Pharmacopeia (USP) limits for large volume injections. Application of the present ACF to patients using a ventricular fiberscope caused no significant adverse effects, such as convulsion, headaches or fever.
{"title":"Preparation of Artificial Cerebrospinal Fluid Using Concentrated Electrolyte Injections.","authors":"O. Fujishita, K. Kuroda, Y. Nakao, Y. Natori, M. Fukui, R. Oishi","doi":"10.5649/JJPHCS1975.22.305","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.22.305","url":null,"abstract":"Two concentrated electrolyte injections (solution A and B) were used for the rapid and easy preparation of artificial cerebrospinal fluid (ACF). Solution A (10 ml) included Na, K, Mg, Ca, Cl, lactate, and glucose while solution B (20 ml) was composed of KH2 PO4 and NaHCO3. Solution A was first added to 0, 9% NaCl in jection (515 ml) maintained in a soft plastic bag followed by solution B. Notably, the prepared ACF had particulate matter counts far less than the Japanese pharmacopoeia (JP) and United States Pharmacopeia (USP) limits for large volume injections. Application of the present ACF to patients using a ventricular fiberscope caused no significant adverse effects, such as convulsion, headaches or fever.","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"82 1","pages":"305-309"},"PeriodicalIF":0.0,"publicationDate":"1996-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77131309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-06-10DOI: 10.5649/JJPHCS1975.22.265
Ayana Suzuki, Naoko Mizogami, T. Orii, Hideyuki Shimizu, T. Seino, Y. Yamamura, Kouichi Nakamura, Y. Sawada, T. Iga
{"title":"Evaluation of Efficacy of Prescription for Rational Use of Medication : Patient Consultation with \"Prescription Card\"","authors":"Ayana Suzuki, Naoko Mizogami, T. Orii, Hideyuki Shimizu, T. Seino, Y. Yamamura, Kouichi Nakamura, Y. Sawada, T. Iga","doi":"10.5649/JJPHCS1975.22.265","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.22.265","url":null,"abstract":"","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"25 1","pages":"265-273"},"PeriodicalIF":0.0,"publicationDate":"1996-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81892131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1996-04-10DOI: 10.5649/JJPHCS1975.22.149
Y. Kagawa, K. Sasaki, M. Matsushima, S. Inagaki, Michio Kojima
A dispensing test of 10% phenytoin powders (10% DPH), which has the same bioavailability as the tablet, was investigated. Pharmaceutical characteristics including an apparent density, a dispersibility, grouping properties and an angle of repose of 10% DPH passed the criteria for dispensing from the hospital pharmacy. Next, according to clinical formulas, we designed the eight standard formulas that consisting 10% DPH with 10% phenobarbital powders, zonisamide powders, carbamazepine
{"title":"Pharmaceutical Evaluation for 10% Phenytoin Powders","authors":"Y. Kagawa, K. Sasaki, M. Matsushima, S. Inagaki, Michio Kojima","doi":"10.5649/JJPHCS1975.22.149","DOIUrl":"https://doi.org/10.5649/JJPHCS1975.22.149","url":null,"abstract":"A dispensing test of 10% phenytoin powders (10% DPH), which has the same bioavailability as the tablet, was investigated. Pharmaceutical characteristics including an apparent density, a dispersibility, grouping properties and an angle of repose of 10% DPH passed the criteria for dispensing from the hospital pharmacy. Next, according to clinical formulas, we designed the eight standard formulas that consisting 10% DPH with 10% phenobarbital powders, zonisamide powders, carbamazepine","PeriodicalId":17399,"journal":{"name":"Journal of the Nippon Hospital Pharmacists Association","volume":"17 1","pages":"149-158"},"PeriodicalIF":0.0,"publicationDate":"1996-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74432698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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