Journal of thermal biology最新文献

Effects of acute high-temperature on gill tissue structure, serum biochemical indices, antioxidant capacity and liver transcriptomics of Thamnaconus septentrionalis

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104098

Ying Chen , Si-Qing Chen , Bo Zhang , Zhi-Jie Zheng , Yu-Ao Zhang , Qing Chang , Juan-Wen Yu , Tian-Shi Zhang , Jin-Chao Zhu , Li Bian

As global extreme heat events become more frequent, aquaculture faces significant challenges due to prolonged high summer temperatures, which lead to elevated water temperatures. Investigating the physiological and biochemical responses of fish to thermal stress, as well as breeding heat-resistant varieties, are essential strategies for addressing these challenges. Thamnaconus septentrionalis is an important aquaculture species in southern China. When water temperatures exceed 30 °C during the summer, this species experiences reduced feeding, growth stagnation, and increased mortality rates. To elucidate the physiological and biochemical response mechanisms of T. septentrionalis under thermal stress, this study established a high-temperature group (30 °C) and a control group (20 °C) for a 48-h thermal stress experiment. Tissue samples were collected from the experimental fish at 0, 12, 24, and 48 h post-stress. The effects of acute thermal stress on gill tissue structure, serum biochemical indicators, liver antioxidant capacity, and liver transcriptomics were explored. The results revealed that the gill tissues of the high-temperature group exhibited slight bending of the gill filaments, terminal swelling, and cellular vacuolization, along with a tendency for adjacent gill filaments to fuse. The liver antioxidant capacity and serum biochemical indicators in the high-temperature group were significantly elevated compared to the control group (P < 0.05). Transcriptomic sequencing identified 5536 differentially expressed genes (P < 0.05), with 2639 genes upregulated and 2897 downregulated. Gene Ontology (GO) enrichment analysis indicated that differentially expressed genes were primarily associated with metabolic processes and redox reactions. KEGG pathway analysis showed significant enrichment of genes in pathways related to amino acid metabolism, carbon metabolism, and glycolysis/gluconeogenesis, with notable downregulation observed in the high-temperature group. This study provides valuable theoretical insights into the mechanisms underlying the response of T. septentrionalis to high-temperature stress, contributing to the understanding of aquaculture resilience in the face of climate change.

{"title":"Effects of acute high-temperature on gill tissue structure, serum biochemical indices, antioxidant capacity and liver transcriptomics of Thamnaconus septentrionalis","authors":"Ying Chen , Si-Qing Chen , Bo Zhang , Zhi-Jie Zheng , Yu-Ao Zhang , Qing Chang , Juan-Wen Yu , Tian-Shi Zhang , Jin-Chao Zhu , Li Bian","doi":"10.1016/j.jtherbio.2025.104098","DOIUrl":"10.1016/j.jtherbio.2025.104098","url":null,"abstract":"<div><div>As global extreme heat events become more frequent, aquaculture faces significant challenges due to prolonged high summer temperatures, which lead to elevated water temperatures. Investigating the physiological and biochemical responses of fish to thermal stress, as well as breeding heat-resistant varieties, are essential strategies for addressing these challenges. <em>Thamnaconus septentrionalis</em> is an important aquaculture species in southern China. When water temperatures exceed 30 °C during the summer, this species experiences reduced feeding, growth stagnation, and increased mortality rates. To elucidate the physiological and biochemical response mechanisms of <em>T. septentrionalis</em> under thermal stress, this study established a high-temperature group (30 °C) and a control group (20 °C) for a 48-h thermal stress experiment. Tissue samples were collected from the experimental fish at 0, 12, 24, and 48 h post-stress. The effects of acute thermal stress on gill tissue structure, serum biochemical indicators, liver antioxidant capacity, and liver transcriptomics were explored. The results revealed that the gill tissues of the high-temperature group exhibited slight bending of the gill filaments, terminal swelling, and cellular vacuolization, along with a tendency for adjacent gill filaments to fuse. The liver antioxidant capacity and serum biochemical indicators in the high-temperature group were significantly elevated compared to the control group (<em>P</em> < 0.05). Transcriptomic sequencing identified 5536 differentially expressed genes (<em>P</em> < 0.05), with 2639 genes upregulated and 2897 downregulated. Gene Ontology (GO) enrichment analysis indicated that differentially expressed genes were primarily associated with metabolic processes and redox reactions. KEGG pathway analysis showed significant enrichment of genes in pathways related to amino acid metabolism, carbon metabolism, and glycolysis/gluconeogenesis, with notable downregulation observed in the high-temperature group. This study provides valuable theoretical insights into the mechanisms underlying the response of <em>T. septentrionalis</em> to high-temperature stress, contributing to the understanding of aquaculture resilience in the face of climate change.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104098"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probiotics/prebiotics effect on chicken gut microbiota and immunity in relation to heat-stress and climate-change mitigation 益生菌/益生元对鸡肠道微生物群和免疫力的影响与热应激和气候变化缓解的关系

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104097

Yara Sayed , Mariam Hassan , Heba M. Salem , Khaled Al-Amry , Gamal Eid

Heat stress is a serious hazard that threatens world poultry production. The avian gut microbiome plays a critical role in improving nutrient utilization, competing with pathogens, stimulating an immune response, and reducing inflammatory reactions. Hence, the gut microbiome has a positive impact on the host's health which appears in the shape of improved body weight, feed conversion rate, and increased birds' productivity (meat or eggs). Accordingly, this review shed light on the chicken gut microbiome, its correlation with the immunity of chicken, and how this affects the general health condition of the bird as well as, the role of prebiotics and probiotics in improving the gut health and increasing birds' productivity, especially under climate change and heat stress condition. The review aims to focus on the significance of maintaining healthy chickens in order to increase the production of poultry meat to satisfy human needs. A robust microbiota and a well-functioning immune system synergistically contribute to the optimal health and productivity of chickens.

{"title":"Probiotics/prebiotics effect on chicken gut microbiota and immunity in relation to heat-stress and climate-change mitigation","authors":"Yara Sayed , Mariam Hassan , Heba M. Salem , Khaled Al-Amry , Gamal Eid","doi":"10.1016/j.jtherbio.2025.104097","DOIUrl":"10.1016/j.jtherbio.2025.104097","url":null,"abstract":"<div><div>Heat stress is a serious hazard that threatens world poultry production. The avian gut microbiome plays a critical role in improving nutrient utilization, competing with pathogens, stimulating an immune response, and reducing inflammatory reactions. Hence, the gut microbiome has a positive impact on the host's health which appears in the shape of improved body weight, feed conversion rate, and increased birds' productivity (meat or eggs). Accordingly, this review shed light on the chicken gut microbiome, its correlation with the immunity of chicken, and how this affects the general health condition of the bird as well as, the role of prebiotics and probiotics in improving the gut health and increasing birds' productivity, especially under climate change and heat stress condition. The review aims to focus on the significance of maintaining healthy chickens in order to increase the production of poultry meat to satisfy human needs. A robust microbiota and a well-functioning immune system synergistically contribute to the optimal health and productivity of chickens.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104097"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fever exerts opposing effects on the binding affinities of two neutralizing monoclonal antibodies against Staphylococcal Enterotoxin B

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104112

Puneet K. Singh , Su-Mi Choi , Ik Joo Chung , Sook In Jung , Razvan C. Stan

Rationale

Infections with methicillin-resistant Staphylococcus aureus are a major source of morbidity and mortality worldwide. While no vaccines against this pathogen are yet available, passive therapy with neutralizing monoclonal antibodies against a key S. aureus toxin, the Staphylococcal Enterotoxin B (SEB), can be clinically effective. Further, fever response is a key symptom of this infection, and typically precedes or is concomitant to antibody therapy against SEB.

Objective

To investigate the role of febrile temperatures on the formation of immune complexes between SEB and two therapeutic monoclonal antibodies, 6D3 and 14G8.

Results

Using molecular dynamics simulations, free binding energy calculations and Surface Plasmon Resonance experiments, we reveal that at high fever (i.e. 312K (39 °C), compared to the physiologic body temperature of 310K (37 °C), the activity of 6D3 mAb is markedly reduced. In contrast, the binding affinity of antibody 14G8 benefits from the higher temperature.

Conclusions

Febrile temperatures differentially affect the binding affinities of monoclonal antibodies used in the therapy against S. aureus, and judicious control of the body temperature of the patients before their administration may potentiate their activity.

{"title":"Fever exerts opposing effects on the binding affinities of two neutralizing monoclonal antibodies against Staphylococcal Enterotoxin B","authors":"Puneet K. Singh , Su-Mi Choi , Ik Joo Chung , Sook In Jung , Razvan C. Stan","doi":"10.1016/j.jtherbio.2025.104112","DOIUrl":"10.1016/j.jtherbio.2025.104112","url":null,"abstract":"<div><h3>Rationale</h3><div>Infections with methicillin-resistant <em>Staphylococcus aureus</em> are a major source of morbidity and mortality worldwide. While no vaccines against this pathogen are yet available, passive therapy with neutralizing monoclonal antibodies against a key <em>S. aureus</em> toxin, the Staphylococcal Enterotoxin B (SEB), can be clinically effective. Further, fever response is a key symptom of this infection, and typically precedes or is concomitant to antibody therapy against SEB.</div></div><div><h3>Objective</h3><div>To investigate the role of febrile temperatures on the formation of immune complexes between SEB and two therapeutic monoclonal antibodies, 6D3 and 14G8.</div></div><div><h3>Results</h3><div>Using molecular dynamics simulations, free binding energy calculations and Surface Plasmon Resonance experiments, we reveal that at high fever (i.e. 312K (39 °C), compared to the physiologic body temperature of 310K (37 °C), the activity of 6D3 mAb is markedly reduced. In contrast, the binding affinity of antibody 14G8 benefits from the higher temperature.</div></div><div><h3>Conclusions</h3><div>Febrile temperatures differentially affect the binding affinities of monoclonal antibodies used in the therapy against <em>S. aureus</em>, and judicious control of the body temperature of the patients before their administration may potentiate their activity.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104112"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of postprandial thermal feeling in mice using a behavioral thermoregulation analysis: Differences in meat species and their fractions

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104101

Jun-ichi Wakamatsu , Yeying Tan , Seiya Kato , Haruka Abe , Manabu Kawahara , Toru Hayakawa , Haruto Kumura

Classification of the thermal nature of meat in traditional Chinese medicine (TCM) varies depending on the meat species and their fractions. The objectives of this study were to establish an experimental system to evaluate postprandial thermal feeling based on behavioral thermoregulation, investigate it among different meat species and their fractions, and clarify the relationship between their thermal nature and the active meat constituents that affect thermal feeling. Freeze-dried meat, defatted meat, and extracted fat were prepared from horse meat, chicken, pork, beef, mutton, and venison. After feeding, mice were placed in an elongated chamber equipped with a continuous thermogradient floor. An obvious peak in the cumulative staying time at the mouse's preferred temperature was observed after 30 min, and the postprandial thermal feeling was evaluated by examining the preferred temperatures. As a result, purified meat proteins were not considered to affect postprandial thermal feeling among meat species. In contrast, the ethanol and water extracts of defatted horse meat induced a “cool feeling,” and the extracts of other meat species induced a “warm feeling.” Chicken and pork fat induced a cool feeling, whereas beef and mutton fat induced a warm feeling. Additionally, certain dose-dependent constituent(s) in these fats affected the postprandial thermal feeling. Using the established evaluation system, it was concluded that the extract and fat in meat are involved in the postprandial thermal feeling, and the thermal nature of the meat in TCM depends not only on animal-specific components but also on their contents.

{"title":"Evaluation of postprandial thermal feeling in mice using a behavioral thermoregulation analysis: Differences in meat species and their fractions","authors":"Jun-ichi Wakamatsu , Yeying Tan , Seiya Kato , Haruka Abe , Manabu Kawahara , Toru Hayakawa , Haruto Kumura","doi":"10.1016/j.jtherbio.2025.104101","DOIUrl":"10.1016/j.jtherbio.2025.104101","url":null,"abstract":"<div><div>Classification of the thermal nature of meat in traditional Chinese medicine (TCM) varies depending on the meat species and their fractions. The objectives of this study were to establish an experimental system to evaluate postprandial thermal feeling based on behavioral thermoregulation, investigate it among different meat species and their fractions, and clarify the relationship between their thermal nature and the active meat constituents that affect thermal feeling. Freeze-dried meat, defatted meat, and extracted fat were prepared from horse meat, chicken, pork, beef, mutton, and venison. After feeding, mice were placed in an elongated chamber equipped with a continuous thermogradient floor. An obvious peak in the cumulative staying time at the mouse's preferred temperature was observed after 30 min, and the postprandial thermal feeling was evaluated by examining the preferred temperatures. As a result, purified meat proteins were not considered to affect postprandial thermal feeling among meat species. In contrast, the ethanol and water extracts of defatted horse meat induced a “cool feeling,” and the extracts of other meat species induced a “warm feeling.” Chicken and pork fat induced a cool feeling, whereas beef and mutton fat induced a warm feeling. Additionally, certain dose-dependent constituent(s) in these fats affected the postprandial thermal feeling. Using the established evaluation system, it was concluded that the extract and fat in meat are involved in the postprandial thermal feeling, and the thermal nature of the meat in TCM depends not only on animal-specific components but also on their contents.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104101"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical thermal maxima of Polistes life stages from different climates, with a critical evaluation of methods

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104111

Helmut Käfer , Helmut Kovac , Astrid B. Amstrup , Jesper G. Sørensen , Anton Stabentheiner

Ambient temperature is a crucial abiotic factor for ectotherms. It strongly influences development, life and abundance, as well as success in colonizing new habitats. In the eusocial paper wasps Polistes sp., colony-forming insects with open nests, the larvae and pupae have limited options to influence their own body temperature in response to high environmental temperatures. They are dependent on measures taken by the adults to keep it at tolerable levels. We determined the upper thermal limits (CT_max) in field populations of three paper wasp species (Polistes dominula, P. gallicus, P. biglumis) from different climates (temperate, Mediterranean, alpine) for three life stages (larvae, pupae, adults). Due to morphological and physiological characteristics of the individual life stages, they did not show the same reactions to temperature rise and heat stress in terms of respiration and body movement. CT_max evaluation by established methods (mortal fall, short-term respiration patterns) was not possible, so we had to develop an adapted evaluation type based on long term respiration patterns. The most striking result was that the CT_max was similar in all populations and life stages, ranging from 47.6 to 48.8 °C in larvae and pupae, and from 47.1 to 47.9 °C in adults. P. dominula differed from P. gallicus and P. biglumis; the latter did not differ significantly (all stages). Tests in individual groups (populations, life stages) showed differences in one parameter or the other (population, life stage, mass). Overall, population (and thus climate as a related factor) and life stage, but not mass, had a significant effect on CT_max.s

环境温度对于外温动物来说是一个至关重要的非生物因素。它对昆虫的发育、生命和数量以及在新栖息地定居的成功与否都有很大影响。在具有开放式巢穴的群居昆虫 Polistes sp.中，幼虫和蛹在应对高环境温度时影响自身体温的选择有限。它们只能依靠成虫采取措施将体温保持在可承受的水平。我们测定了三种纸蜂（Polistes dominula、P. gallicus、P. biglumis）在不同气候条件下（温带、地中海、高山）三个生命阶段（幼虫、蛹、成虫）的野外种群热上限（CTmax）。由于各生命阶段的形态和生理特点不同，它们对温度升高和热应激在呼吸和身体运动方面的反应也不尽相同。因此，我们必须开发一种基于长期呼吸模式的适应性评估方法。最显著的结果是，所有种群和生命阶段的 CTmax 都相似，幼虫和蛹的 CTmax 为 47.6 至 48.8 °C，成虫的 CTmax 为 47.1 至 47.9 °C。P.dominula与P.gallicus和P.biglumis不同；后者没有显著差异（所有阶段）。对单个组别（种群、生命阶段）的测试表明，其中一个参数或其他参数（种群、生命阶段、质量）存在差异。总体而言，种群（因此气候也是一个相关因素）和生命阶段对 CTmax.s 有显著影响，但对质量没有显著影响。

{"title":"Critical thermal maxima of Polistes life stages from different climates, with a critical evaluation of methods","authors":"Helmut Käfer , Helmut Kovac , Astrid B. Amstrup , Jesper G. Sørensen , Anton Stabentheiner","doi":"10.1016/j.jtherbio.2025.104111","DOIUrl":"10.1016/j.jtherbio.2025.104111","url":null,"abstract":"<div><div>Ambient temperature is a crucial abiotic factor for ectotherms. It strongly influences development, life and abundance, as well as success in colonizing new habitats. In the eusocial paper wasps <em>Polistes</em> sp.<em>,</em> colony-forming insects with open nests, the larvae and pupae have limited options to influence their own body temperature in response to high environmental temperatures. They are dependent on measures taken by the adults to keep it at tolerable levels. We determined the upper thermal limits (CT<sub>max</sub>) in field populations of three paper wasp species (<em>Polistes dominula</em>, <em>P. gallicus</em>, <em>P. biglumis</em>) from different climates (temperate, Mediterranean, alpine) for three life stages (larvae, pupae, adults). Due to morphological and physiological characteristics of the individual life stages, they did not show the same reactions to temperature rise and heat stress in terms of respiration and body movement. CT<sub>max</sub> evaluation by established methods (mortal fall, short-term respiration patterns) was not possible, so we had to develop an adapted evaluation type based on long term respiration patterns. The most striking result was that the CT<sub>max</sub> was similar in all populations and life stages, ranging from 47.6 to 48.8 °C in larvae and pupae, and from 47.1 to 47.9 °C in adults. <em>P. dominula</em> differed from <em>P. gallicus</em> and <em>P. biglumis</em>; the latter did not differ significantly (all stages). Tests in individual groups (populations, life stages) showed differences in one parameter or the other (population, life stage, mass). Overall, population (and thus climate as a related factor) and life stage, but not mass, had a significant effect on CT<sub>max</sub>.s</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104111"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143823355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A numerical study on optimization of microwave antenna power for liver cancer therapy enhanced with hybrid magnetic nanoparticles

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104117

Soheil S. Fakhradini, Mehdi Mosharaf-Dehkordi, Hossein Ahmadikia

Microwave thermal therapy for liver cancer presents challenges due to the potential for healthy tissue damage. This study explores the use of hybrid magnetic nanofluids to optimize treatment effectiveness while minimizing side effects. Preoperative modeling was employed to determine the optimal nanoparticle type, concentration, and combination for enhanced thermal efficiency. Three magnetic nanoparticles—maghemite, magnetite, and FccFePt—were analyzed, both individually and in hybrid compositions. Results demonstrated that increasing nanoparticle concentration significantly reduced treatment duration and minimized healthy tissue necrosis. At 0.1 % concentration, treatment times for maghemite, magnetite, and FccFePt were 3, 67, and 90 s, with corresponding healthy tissue loss-to-tumor volume ratios of 0.06, 3.08, and 4.36. Lowering the concentration to 0.05 % increased treatment times to 46, 126, and 129 s, raising tissue loss ratios to 1.88, 6.65, and 8.36. Notably, hybrid nanoparticle compositions showed divers but non-uniform effects, with some combinations marginally improving treatment efficacy while others had negligible impact. The hybridization of maghemite and FccFePt reduced necrosis time, but its influence on overall treatment efficiency was inconsistent. These findings underscore the potential of hybrid nanoparticles to enhance microwave ablation therapy; however, they also highlight the complexity of nanoparticle interactions, emphasizing the need for precise selection and concentration optimization to achieve superior treatment outcomes while preserving healthy tissue.

{"title":"A numerical study on optimization of microwave antenna power for liver cancer therapy enhanced with hybrid magnetic nanoparticles","authors":"Soheil S. Fakhradini, Mehdi Mosharaf-Dehkordi, Hossein Ahmadikia","doi":"10.1016/j.jtherbio.2025.104117","DOIUrl":"10.1016/j.jtherbio.2025.104117","url":null,"abstract":"<div><div>Microwave thermal therapy for liver cancer presents challenges due to the potential for healthy tissue damage. This study explores the use of hybrid magnetic nanofluids to optimize treatment effectiveness while minimizing side effects. Preoperative modeling was employed to determine the optimal nanoparticle type, concentration, and combination for enhanced thermal efficiency. Three magnetic nanoparticles—maghemite, magnetite, and FccFePt—were analyzed, both individually and in hybrid compositions. Results demonstrated that increasing nanoparticle concentration significantly reduced treatment duration and minimized healthy tissue necrosis. At 0.1 % concentration, treatment times for maghemite, magnetite, and FccFePt were 3, 67, and 90 s, with corresponding healthy tissue loss-to-tumor volume ratios of 0.06, 3.08, and 4.36. Lowering the concentration to 0.05 % increased treatment times to 46, 126, and 129 s, raising tissue loss ratios to 1.88, 6.65, and 8.36. Notably, hybrid nanoparticle compositions showed divers but non-uniform effects, with some combinations marginally improving treatment efficacy while others had negligible impact. The hybridization of maghemite and FccFePt reduced necrosis time, but its influence on overall treatment efficiency was inconsistent. These findings underscore the potential of hybrid nanoparticles to enhance microwave ablation therapy; however, they also highlight the complexity of nanoparticle interactions, emphasizing the need for precise selection and concentration optimization to achieve superior treatment outcomes while preserving healthy tissue.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104117"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractional modeling with optimized variable order for the thermal impacts of mobile phones on the auricular region 针对手机对耳廓区域的热影响，采用优化变量阶次的分数模型

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104104

M. Khalaf , W.K. Zahra

Fractional derivatives with variable order offer a powerful extension to the traditional fractional and integer derivatives, allowing adaptability well-suited for modeling complex, real-world systems with evolving memory and non-local properties. This study presents a variable-order fractional model to simulate the thermal effects of the mobile phone on the auricular region in different operating modes. Laplace transform is used to solve the proposed model to simulate the heat transfer dynamics between the ear and the smartphone. Numerical simulations are presented, demonstrating the effectiveness of the variable fractional order in predicting thermal performance over conventional approaches. The results demonstrate that the fractional model provides a more accurate representation of thermal memory effects and nonlocal heat conduction in biological tissues compared with traditional models. Furthermore, a detailed parametric analysis reveals the influence of the fractional order on heat dissipation rates, aligning well with thermographic observations. This study highlights the effectiveness of variable-order fractional modeling in capturing complex heat transfer dynamics, offering a more precise framework for thermal analysis in biomedical and electronic applications.

{"title":"Fractional modeling with optimized variable order for the thermal impacts of mobile phones on the auricular region","authors":"M. Khalaf , W.K. Zahra","doi":"10.1016/j.jtherbio.2025.104104","DOIUrl":"10.1016/j.jtherbio.2025.104104","url":null,"abstract":"<div><div>Fractional derivatives with variable order offer a powerful extension to the traditional fractional and integer derivatives, allowing adaptability well-suited for modeling complex, real-world systems with evolving memory and non-local properties. This study presents a variable-order fractional model to simulate the thermal effects of the mobile phone on the auricular region in different operating modes. Laplace transform is used to solve the proposed model to simulate the heat transfer dynamics between the ear and the smartphone. Numerical simulations are presented, demonstrating the effectiveness of the variable fractional order in predicting thermal performance over conventional approaches. The results demonstrate that the fractional model provides a more accurate representation of thermal memory effects and nonlocal heat conduction in biological tissues compared with traditional models. Furthermore, a detailed parametric analysis reveals the influence of the fractional order on heat dissipation rates, aligning well with thermographic observations. This study highlights the effectiveness of variable-order fractional modeling in capturing complex heat transfer dynamics, offering a more precise framework for thermal analysis in biomedical and electronic applications.</div></div>","PeriodicalId":17428,"journal":{"name":"Journal of thermal biology","volume":"129 ","pages":"Article 104104"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143776726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling heat transfer in biological tissues with temperature-dependent properties under the moving heat source effects

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104110

Yingze Wang, Zhaowei He, Sheng Zhang, Zhe Wang, Wenbo Zheng

The effects of temperature-dependent physical parameters on the thermal behavior of biological tissue subjected to a moving heat source have been studied in present work. A nonlinear bio-heat transfer model incorporating dual-phase lag and Arrhenius equations has been proposed. Using a hybrid Laplace transform and numerical inversion approach, the temperature distribution and thermal damage under various moving heat sources has been obtained and illustrated. Comparative analyses reveal significant differences in tissue thermal response between temperature-dependent and independent parameters across different heat source velocities. Key findings highlight the substantial impact of temperature-dependent specific heat capacity, thermal conductivity, and blood perfusion rate on tissue thermal behavior.

引用次数: 0

Role of the nasal cavity as a perception site of environmental humidity via a menthol-sensitive cold reception mechanism

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104109

Hironori Watanabe , Issei Kato , Taisuke Sugi , Kei Nagashima

Humans can sense environmental humidity; however, the mechanism underlying this ability remains unclear. This study aimed to clarify whether the nasal cavity is involved in humidity sensation. Experiments were conducted on healthy young adults, in which controlled nasal inhalation was conducted under four air conditions (i.e., temperature of 25 °C or 34 °C with relative humidity [RH] of 30 % and 70 %). The temperature of the nasal mucosa and the thermal and humidity sensations of the inhaled air were assessed in the first experiment. In the second and third experiments, sublimated l-menthol was added to the inhaled air, and the sensations of the inhaled air were evaluated. The temperature of the nasal mucosa was higher in inhaled air at 34 °C with 30 % RH than at 25 °C. The rating for thermal sensation (warm sensation) was the highest at 34 °C and 70 % RH. At both temperatures, the humidity sensation rating was higher in air with 70 % RH than in air with 30 % RH. Linear relationships were observed between the ratings for thermal and humidity sensations under the four conditions (R² = 0.339–0.516). The thermal sensation rating decreased when air at 34 °C was inhaled with l-menthol. A linear relationship was also observed between the ratings for thermal and humidity sensations under this condition (R² = 0.665). These findings suggest that the nasal cavity is critical for the sensation of humidity in an environment in which cold reception via the TRPM8 channel is involved.

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引用次数: 0

Daily and seasonal features in the hind limb withdrawal latency of tegus (Salvator merianae) and green iguanas (Iguana iguana)

IF 2.9 2区生物学 Q2 BIOLOGY

Journal of thermal biology

Pub Date : 2025-04-01 DOI: 10.1016/j.jtherbio.2025.104099

Shayne Pedrozo Bisetto, André Augusto Justo, Thais Feres Bressan, Willian Petroni Leal, Adriano Bonfim Carregaro

This study evaluated the effects of daytime and season on the limb withdrawal latency time (LWLT) of lizards. Captive-raised, juvenile tegus and green iguanas (n = 6 each) were housed indoors, where a temperature gradient (27–40 °C) and a constant photoperiod (12-h cycle) were provided. Body temperatures and LWLT were measured at 00:00 h, 06:00 h, 12:00 h and 18:00 h over winter, spring, summer and fall. Both lizards had body temperatures lower than 30 °C at 00:00 h/06:00 h and higher than 30 °C at 12:00 h/18:00 h. In spring, tegus had higher body temperatures than in fall at 12:00 h (34.2 ± 1.4 °C versus 30.3 ± 1.9 °C) and in winter at 18:00 h (33.6 ± 1.2 °C versus 30.4 ± 1.0 °C); iguanas presented increased body temperatures at 00:00 h in summer (28.1 °C [28.0–28.2]) compared to winter (25.5 °C [25.3–25.7]). The LWLT of tegus was elevated at 06:00 h compared to 12:00 h and 18:00 h in winter (12.0 ± 3.8 s versus 7.6 ± 1.8 s and 7.0 ± 3.2 s, respectively), spring (12.0 ± 2.7 s versus 7.4 ± 3.1 s and 7.7 ± 1.3 s, respectively) and fall (14.8 ± 2.3 s versus 10.2 ± 1.2 s and 8.9 ± 1.9 s, respectively). Iguanas showed season-related fluctuations in LWLT, with higher values at 18:00 h in winter (15.5 ± 6.1 s) and fall (14.8 ± 2.6 s) than in summer (9.2 ± 1.9 s), as well as higher at 00:00 h (16.6 ± 5.4 s) and 12:00 h (15.4 ± 3.9 s) in spring than in summer (11.0 ± 2.9 s and 9.3 ± 1.3 s, respectively). Body temperature was poorly correlated with LWLT in tegus (r_s = - 0.292; p = 0.003) and iguanas (r_s = - 0.143; p = 0.162). Researchers should consider circadian and circannual rhythms as potential biases in antinociception-focused lizard studies.

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引用次数: 0