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Photobiomodulation in carpal tunnel syndrome with pain, strength, and functionality analysis: a systematic review and meta-analysis. 腕管综合征疼痛、力量和功能的光生物调节分析:系统回顾和荟萃分析。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-08 DOI: 10.1007/s10103-024-04276-9
Ana Cristhini Lauxen, Debora Regina Machado, Debora Stefhani Pereira, Larissa Beatriz de Medeiros, Dernival Bertoncello, Márcia Rosângela Buzanello, Gladson Ricardo Flor Bertolini

Background: Carpal tunnel syndrome (CTS) is characterized as a compressive neuropathy of the median nerve and has several treatments, including photobiomodulation, which can be performed with low-intensity laser therapy (LLLT) and light-emitting diodes (LEDs).

Purpose: To carry out a literature review on the effectiveness of low-intensity laser therapy (LLLT) in CTS.

Methods: This study is characterized by being a systematic review with metaanalysis. The databases included were PubMed, Embase, Cochrane, the Physiotherapy Evidence Database (PEDro), Scopus and LILACS. Also, gray literature: Google Scholar, OpenGrey and CAPES Theses and Dissertations Catalog. The search was carried out in all databases on October 11, 2023 and updated on June 06, 2024. The risk of bias was assessed using the Cochrane tool, RoB 2, by two blinded reviewers and conflicts were resolved by consensus. The outcomes of interest were pain intensity (Visual analogue scale), strength (handgrip and pinch) and hand functionality (Boston questionnaire, Levine questionnaire, Purdue Pergboard Test). Statistical analysis was carried out using RevMan 5.4.1. Continuous results were expressed as standard mean differences (95% CI), with p-value of < 0.05 considered statistically significant. The value of the I2 statistical test was calculated to test for heterogeneity between studies. A random effects model was adopted.

Results: 13 randomized controlled trials were selected from 1.613 records. In the general bias analysis, two studies (15,4%) were considered to have some relevant problems that could interfere with the quality of the study, and three (23,1%) were identified as having a high risk of bias, eight studies (61,5%) were classified as having a low risk of bias. In the meta-analysis, it was possible to observe that there were no advantages of the laser for pain (p = 0.08), nor for handgrip strength (p = 0.11), but it did produce improvements in functionality.

Conclusion: It is concluded that LLLT is an effective therapeutic modality in the treatment of CTS, improving functionality; however, despite the studies pointing to advantages for the modality in reducing pain and improving grip strength, the meta-analysis did not show this result. Even so, there is a need for more clinical trials are needed to standardize dosimetry, mainly because the primary studies showed clinical advantages of PBM.

Registration: Open Science Framework (OSF)- https://doi.org/10.17605/OSF.IO/HQCRP .

背景:腕管综合征(Carpal tunnel syndrome, CTS)的特点是正中神经的压迫性神经病变,有几种治疗方法,包括光生物调节,可通过低强度激光治疗(LLLT)和发光二极管(led)进行。目的:对低强度激光治疗CTS的疗效进行文献综述。方法:本研究的特点是采用系统综述和荟萃分析。纳入的数据库包括PubMed、Embase、Cochrane、物理治疗证据数据库(PEDro)、Scopus和LILACS。灰色文献:谷歌Scholar, OpenGrey和CAPES论文目录。该搜索于2023年10月11日在所有数据库中进行,并于2024年6月6日更新。偏倚风险由两位盲法审稿人使用Cochrane工具RoB 2进行评估,冲突通过共识解决。感兴趣的结果是疼痛强度(视觉模拟量表)、力量(握力和握力)和手功能(Boston问卷、Levine问卷、Purdue Pergboard Test)。采用RevMan 5.4.1软件进行统计分析。连续结果用标准均值差(95% CI)表示,结果的p值为:从1.613条记录中选择13项随机对照试验。在一般偏倚分析中,有2项研究(15.4%)被认为存在可能影响研究质量的相关问题,3项研究(23.1%)被确定为具有高偏倚风险,8项研究(61.5%)被归类为具有低偏倚风险。在荟萃分析中,可以观察到激光在疼痛方面没有优势(p = 0.08),在握力方面也没有优势(p = 0.11),但它确实改善了功能。结论:LLLT是治疗CTS的一种有效的治疗方式,可改善功能;然而,尽管研究指出了这种方式在减轻疼痛和提高握力方面的优势,但meta分析并没有显示出这一结果。即便如此,仍需要更多的临床试验来规范剂量测定,主要是因为初步研究显示了PBM的临床优势。注册:开放科学框架(OSF)- https://doi.org/10.17605/OSF.IO/HQCRP。
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引用次数: 0
High-intensity versus low-level laser therapy in treatment of patients with subacromial impingement syndrome: a randomized, double-blind, controlled trial. 高强度与低强度激光治疗肩峰下撞击综合征患者:一项随机、双盲、对照试验。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-06 DOI: 10.1007/s10103-024-04262-1
Marwa Shafiek Saleh, Dina Othman Shokri Galal, Mostafa S Ali, Doaa I Ibrahim

To compare the effects of High-Intensity Laser Therapy (HILT) versus Low-Level Laser Therapy (LLLT) on shoulder pain and disability, shoulder Range of Motion (ROM), Pain Pressure Threshold (PPT), and sleep quality of patients having Subacromial Impingement Syndrome (SAIS). Forty-two patients with SAIS were randomly assigned into three groups, the HILT group (n = 14), the LLLT group (n = 14), and control group (n = 14). All groups received an exercise program consisted of shoulder muscles stretching and strengthening exercises. Along with the exercise program, the HILT group received HILT at 810 nm /980 nm, and LLLT group received LLLT at 904 nm, three times weekly for three weeks. The primary outcome was the change in shoulder pain and disability measured by Shoulder Pain and Disability Index (SPADI). Secondary outcomes included shoulder ROM using a standard goniometer, PPT measured by pressure algometer, and sleep quality by Pittsburgh Sleep Quality Index (PSQI). Measurements were taken both before and after a 3-week intervention to assess the outcomes. After 3-wk intervention, both the HILT and LLLT groups exhibited significant improvements in all parameters when compared to the control group (p < 0.05). Additionally, there were clinically significant differences between groups supported by a large ES favoring the HILT group for SPADI pain (ηp2 = 0.71), SPADI disability (ηp2 = 0.54), SPADI total (ηp2 = 0.82), PPT (ηp2 = 0.63), and PSQI (ηp2 = 0.42). The combination of HILT with exercises proved to be more beneficial in enhancing pain and function, PPT, and sleep quality compared to LLLT combined with exercises in treating patients with SAIS.

比较高强度激光治疗(HILT)与低强度激光治疗(LLLT)对肩峰下撞击综合征(SAIS)患者肩关节疼痛和残疾、肩关节活动度(ROM)、痛压阈值(PPT)和睡眠质量的影响。42例SAIS患者随机分为三组,HILT组(n = 14)、LLLT组(n = 14)和对照组(n = 14)。所有小组都接受了包括肩部肌肉伸展和强化练习的锻炼计划。在运动计划的同时,HILT组接受810 nm /980 nm的hillt, LLLT组接受904 nm的LLLT,每周3次,持续3周。主要结局是肩痛和失能指数(SPADI)测量的肩痛和失能的变化。次要结果包括使用标准角计测量肩部ROM,使用压力测量仪测量PPT,以及使用匹兹堡睡眠质量指数(PSQI)测量睡眠质量。在3周干预之前和之后进行测量以评估结果。干预3周后,HILT组和LLLT组在所有参数上均较对照组(p 2 = 0.71)、SPADI失能(ηp2 = 0.54)、SPADI总分(ηp2 = 0.82)、PPT (ηp2 = 0.63)和PSQI (ηp2 = 0.42)均有显著改善。在治疗SAIS患者时,与LLLT联合运动相比,HILT联合运动在改善疼痛和功能、PPT和睡眠质量方面更有益。
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引用次数: 0
Effective treatment of xanthelasma palpebrarum using Er:YAG laser. Er:YAG激光有效治疗睑黄斑。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-06 DOI: 10.1007/s10103-024-04273-y
Hojin Park, Su Bin Lee, Jae-Ho Chung, Seung Ha Park

Xanthelasma palpebrarum (XP), characterized by soft, yellowish plaque primarily on the eyelids, is often associated with lipid metabolism disorders. XP can cause aesthetic concerns that affect social interactions and requires careful treatment evaluations due to potential complications and associations with systemic conditions. We aimed to assess the efficacy of and recurrence rates with erbium:yttrium aluminum garnet (Er:YAG) laser therapy in the treatment of XP. This was a retrospective review involving 214 patients treated with a 2,940 nm Er:YAG laser for XP from January 2021 to June 2023. Treatment efficacy was evaluated using standardized photography and the Vancouver Scar Scale (VSS), with follow-up assessments noting any complications or recurrence. The 214 patients with 457 lesions exhibited a complete removal of lesions post-treatment. Complications were minimal, with hypertrophic scarring occurring in 1.5% of patients and a recurrence rate of 10.5%. Patients with multiple lesions had a higher recurrence rate compared with those with single lesions. Based on VSS evaluation, 66.8% of patients (n = 143) were categorized as having excellent outcomes, while 29.0% (n = 62) were classified as having good outcomes. Er:YAG laser therapy has proven to be an effective and safe treatment modality for XP, accurately and safely removing lesions with minimal recurrence rates. It can achieve complete lesion removal, with recurrence at the treated site being very low. Additionally, Er:YAG laser treatment offers several advantages over surgical methods, making it a promising candidate to become the first-line treatment of choice for XP.

眼睑黄斑病(XP),主要表现为眼睑上的淡黄色斑块,常与脂质代谢紊乱有关。XP可能引起影响社会互动的美学问题,并且由于潜在的并发症和与系统状况的关联,需要仔细的治疗评估。我们旨在评估铒钇铝石榴石(Er:YAG)激光治疗XP的疗效和复发率。这是一项回顾性研究,从2021年1月到2023年6月,214例患者接受了2,940 nm Er:YAG激光治疗XP。使用标准化摄影和温哥华疤痕量表(VSS)评估治疗效果,随访评估是否有并发症或复发。214例患者的457个病变在治疗后完全切除。并发症极少,增生性瘢痕的发生率为1.5%,复发率为10.5%。多发病变患者的复发率高于单发病变患者。根据VSS评价,66.8% (n = 143)的患者预后为优,29.0% (n = 62)的患者预后为良。Er:YAG激光治疗已被证明是一种有效和安全的治疗XP的方式,准确和安全地切除病变,复发率最低。它可以完全切除病灶,治疗部位的复发率非常低。此外,Er:YAG激光治疗与手术方法相比有几个优点,使其成为XP的一线治疗选择。
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引用次数: 0
Impact of short and long-term application of low-level laser therapy on mandibular alveolar process of osteoporotic rats - a Histological and Molecular Study. 短期和长期应用低水平激光治疗对骨质疏松大鼠下颌牙槽进程影响的组织学和分子研究。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-03 DOI: 10.1007/s10103-024-04246-1
Mai O El-Halwagy, Enas M Hegazy, Hany K Shalaby, Elham F Mahmoud

This study aims to investigate and compare the effects of short and long-term application of low-level laser therapy on the mandibular alveolar process of osteoporotic rats. Forty adult male albino rats were included in this study. After animal grouping, the experimental group received dexamethasone (0.1 mg/kg b.wt./day for 60 days) for the induction of osteoporosis, then the rats were treated using LLLT (830 nm, 100 mW, at 60 J/cm2). The lower jaw specimens were collected and processed for histological, molecular, and histomorphometric assessments. The osteoporotic group exhibited alveolar bone resorption, accompanied by significantly upregulated RANKL and downregulated OPG mRNA expression. The short-term application of laser group showed alveolar bone partial improvement with slightly downregulated RANKL and slightly upregulated OPG levels. The long-term application of laser group showed dramatic positive changes in the alveolar bone, with markedly downregulated RANKL and upregulated OPG levels. LLLT shows potential as a low-risk and impactful local management for osteoporosis, with long-term laser application demonstrably improving bone quality, quantity, and organization compared to short-term application.

本研究旨在探讨和比较短期和长期应用低水平激光治疗对骨质疏松大鼠下颌牙槽突的影响。本研究选用40只成年雄性白化大鼠。动物分组后,实验组给予地塞米松(0.1 mg/kg b.wt);/天,共60天)诱导骨质疏松,然后用LLLT (830 nm, 100 mW, 60 J/cm2)治疗大鼠。收集下颌标本并进行组织学、分子和组织形态学评估。骨质疏松组表现为牙槽骨吸收,RANKL显著上调,OPG mRNA表达下调。激光组短期应用后牙槽骨部分改善,RANKL轻度下调,OPG轻度上调。长期应用激光组牙槽骨出现明显的积极变化,RANKL明显下调,OPG水平明显上调。LLLT显示出作为一种低风险和有效的骨质疏松症局部治疗的潜力,与短期应用相比,长期激光应用明显改善骨质量、数量和组织。
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引用次数: 0
Evaluation of two low-level laser techniques as an adjunct to basic periodontal therapy: a randomized clinical trial. 评估两种低水平激光技术作为基本牙周治疗的辅助:一项随机临床试验。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-03 DOI: 10.1007/s10103-024-04275-w
Régia Carla Medeiros da Silva, Lucas Gabriel Cunha da Silva, Natália Teixeira da Silva Cruz, Ádylla Rominne Lima Barbosa, Paulo Raphael Leite Maia, Ana Rafaela Luz de Aquino Martins

To assess and compare two techniques of low-level laser application-transgingival (TLLLT) and intrasulcular (ILLLT)-used in photobiomodulation as an adjunct to basic periodontal therapy (BPT) in patients with periodontitis. A randomized, split-mouth, double-blind clinical trial was conducted, selecting three diseased periodontal sites from different quadrants in each patient. These sites were assigned to one of three treatment groups: SRP (control), SRP + TLLLT (test 1), and SRP + ILLLT (test 2). Low-level laser therapy in the test groups was applied at 48 h, 7 days, and 14 days after full-mouth SRP. Clinical parameters such as probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) were assessed at baseline (T0), 3 months (T1), and 6 months (T2). Standardized periapical radiographs were used to assess radiographic bone density (RBD) 6 months post-treatment. Statistical analyses included repeated measures ANOVA for continuous variables and chi-square tests for categorical variables, with significance set at p < 0.05 and a 95% confidence interval. Significant reductions in PD (p < 0.001) and CAL (p < 0.001) were observed across all groups at 3 and 6 months, with no significant differences between groups. There were also no significant changes in BOP and RBD between groups at the follow-up intervals. Adjunctive photobiomodulation did not provide additional clinical or radiographic benefits over SRP alone, regardless of the laser application technique employed.

目的:评估和比较两种低强度激光应用技术--经龈(TLLLT)和肌内(ILLLT)--作为牙周炎患者基本牙周治疗(BPT)的辅助手段,在光生物调节中的应用。我们进行了一项随机、分口、双盲临床试验,从每位患者的不同象限选择三个牙周病变部位。这些部位被分配到三个治疗组中的一个:SRP(对照组)、SRP + TLLLT(试验 1)和 SRP + ILLLT(试验 2)。测试组的低强度激光治疗分别在全口 SRP 后 48 小时、7 天和 14 天进行。在基线(T0)、3 个月(T1)和 6 个月(T2)时评估临床参数,如探诊深度(PD)、临床附着水平(CAL)和探诊出血量(BOP)。治疗后 6 个月,使用标准化根尖周X光片评估放射骨密度(RBD)。统计分析包括连续变量的重复测量方差分析和分类变量的卡方检验,显著性以 P
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引用次数: 0
Percutaneous photoacoustic debulking of infra-inguinal atherosclerotic disease- early European experience with a novel, solid-state, pulsed -wave, ultraviolet 355 nm laser. 经皮光声消肿治疗腹股沟下动脉粥样硬化疾病——欧洲早期使用新型固态脉冲波紫外355nm激光的经验
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2025-01-02 DOI: 10.1007/s10103-024-04216-7
Wacław Kuczmik, Grzegorz Oszkinis, Łukasz Kruszyna, Michał Goran Stanisić, Wojciech Zelawski, Jacek Kostecki, David Planer, Luis R Leon, Yossi Muncher, Oshrat Cohen, On Topaz
<p><p>The broad spectrum of clinical manifestations caused by peripheral arterial disease [PAD] and the morphologic heterogeneity of associated atherosclerotic lesions present a considerable management challenge. Endovascular interventions are recognized an effective treatment for PAD. Within this revascularization strategy the role of atherectomy debulking modalities continue to evolve. Accordingly, the study herein assessed the efficacy and safety of a novel, solid state, Nd: YAG pulsed-wave [355 nm wavelength] laser atherectomy in the treatment of symptomatic infra-inguinal PAD. The EX-PAD-01 study, a prospective, single-arm, open label trial enrolled 50 patients (38 males, 12 females; mean age 64 years] with symptomatic peripheral arterial disease, who underwent percutaneous revascularization with a novel, solid state, pulsed-wave [355 nm wavelength] laser atherectomy followed with adjunct treatment. The Ankle-brachial index [ABI], Rutherford classification for chronic limb ischemia and the walking impairment questionnaire [WIQ] were used for assessment of the index clinical condition of the enrolled patients, for post procedure evaluation and during follow-up. Accordingly, the patients were followed for 12-months with repeated direct physician contact visits. Fifty-three atherosclerotic stenoses (51 femoropopliteal, 2 tibial) with a mean length of 7.4 cm. (ranged 1cm to 25cm) were treated. There were 79% occlusions, and 61% containing moderate-to-severe calcifications. The pre-procedure stenosis was 95.3 ± 10.3%, the Rutherford classification for chronic limb ischemia [CLI] was 2.90 ± 0.54 ranging between 2-4 and the WIQ 34.6 ± 8.62. Technical success was achieved in 52 of the 53 (98%) target lesions. Following laser debulking the baseline stenosis was reduced from 95.3 ± 10.3% to 61.3 ± 25.5% [ [p < 0.0001] and with adjunct balloon/stenting to final of 14.0 ± 14.0% [p < 0.0001]. Embolic protection devices were utilized in 6 [12%] patients. At 30-day post procedure evaluation the ABI increased from baseline of 0.57 ± 0.14 to 0.94 ± 0.14 [p < 0.0001] and no major adverse effects or device adverse effects were detected. At 6 months follow -up the ABI was 0.84 ± 0.20% (p < 0.0001 vs. initial) and at 1 year follow-up 0.79 ± 0.16 (P = 0.0001 vs. initial) without major adverse events. Out of 46 [92%] patients who reached the 12 months follow-up mark, 2 [4.3%] experienced clinically driven target lesion revascularization. Sustained clinical benefit for up to 12 months post procedure was demonstrated through documentation of statistically significant decrease of Rutherford CLI class as well as concomitant improvement in WIQ score and an increase of ABI value. The primary patency rate, as defined by peak systolic velocity ratio (PSVR) of < 2.5m/second was 95.7% (22 of 23) and 81.8% (18 of 22) at 6 months and 12 months, respectively. In an early European clinical experience with a series of 50 patients with symptomatic peripheral arterial disease, the
外周动脉疾病(PAD)引起的广泛临床表现和相关动脉粥样硬化病变的形态学异质性给治疗带来了相当大的挑战。血管内介入治疗是公认的治疗PAD的有效方法。在这种血运重建策略中,动脉粥样硬化切除术的作用继续发展。因此,本研究评估了一种新型固态Nd: YAG脉冲波[355nm波长]激光动脉粥样硬化切除术治疗症状性腹股沟下PAD的有效性和安全性。EX-PAD-01研究是一项前瞻性、单臂、开放标签试验,入组了50例患者(男性38例,女性12例;患者平均年龄64岁,伴有症状性外周动脉疾病,采用新型固体脉冲波[355 nm波长]激光动脉粥样硬化切除术进行经皮血管重建术,随后进行辅助治疗。采用踝臂指数(Ankle-brachial index, ABI)、慢性肢体缺血Rutherford分类法及行走障碍问卷(walking impairment questionnaire, WIQ)评估入组患者的指标临床状况、术后评价及随访。因此,对患者进行了12个月的随访,反复与医生直接接触。53例动脉粥样硬化性狭窄(股腘动脉51例,胫骨动脉2例),平均长度7.4 cm。(范围1cm ~ 25cm)。有79%的闭塞,61%包含中度至重度钙化。术前狭窄95.3±10.3%,慢性肢体缺血Rutherford分级(CLI) 2.90±0.54,WIQ 34.6±8.62。53例靶病变中有52例(98%)技术成功。激光降压后,基线狭窄从95.3±10.3%降至61.3±25.5%
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引用次数: 0
The effect of Er:YAG laser irradiation with different frequencies on surface decontamination of used healing abutments: a supplementary approach to sterilization. 不同频率Er:YAG激光照射对愈合基牙表面去污的影响:一种辅助灭菌的方法。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-31 DOI: 10.1007/s10103-024-04274-x
Sarah Sadat Ehsani, Mahmood Ghasemi, Ardavan Etemadi

Reusing healing abutments is common practice among clinicians; however, ensuring complete surface decontamination is crucial to avoid further complications. This study aimed to evaluate the cleaning potential of Er: YAG laser at different frequencies, as an adjunctive step prior to autoclave sterilization. Forty contaminated healing abutments were divided into four groups. Positive control group included mechanical wiping and ultrasonic bath, Er: YAG laser (50 mJ/pulse, 100 µsec, water 30%, air 70%) at 20 Hz, 30 Hz, and 40 Hz with the powers of 1 W, 1.5 W, and 2 W respectively. Three unused healing abutments were used as the negative control group. Samples were stained with phloxine B and then photographed using a light microscope. The proportion of stained and contaminated areas on each healing abutment was then quantified using ImageJ. Statistical analysis showed significant differences in the amount of remaining debris among the groups (P < 0.05). The group treated with the Er: YAG laser at 40 Hz demonstrated the most effective decontamination, with the least residual debris observed across all HA surfaces. Higher laser frequencies correlated with reduced contamination, particularly in the body and top areas of the HAs. The Er: YAG laser, particularly at 50 mJ/pulse and 40 Hz, proved to be an effective method for decontaminating used HAs. This laser treatment may offer a reliable protocol for reusing HAs, enhancing the safety and success of implant therapy.

重复使用愈合基台是临床医生的常见做法;然而,确保完全的表面净化是避免进一步并发症的关键。本研究旨在评估不同频率的Er: YAG激光作为高压灭菌器灭菌前的辅助步骤的清洁潜力。将40个污染愈合基牙分为4组。阳性对照组为机械擦拭和超声浴,Er: YAG激光(50 mJ/脉冲,100µs,水30%,空气70%),频率分别为20、30、40 Hz,功率分别为1 W、1.5 W、2 W。3个未使用的修复基牙作为阴性对照组。样品用苯二酚B染色,然后用光学显微镜拍照。然后使用ImageJ对每个愈合基台上染色和污染区域的比例进行量化。统计分析表明,各组间残留碎片数量差异有统计学意义(P
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引用次数: 0
Safety and efficacy of low-powered holmium laser enucleation of the prostate in comparison with plasma kinetic resection of prostate. 低功率钬激光前列腺除核术与血浆动力前列腺切除术的安全性和有效性比较。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-28 DOI: 10.1007/s10103-024-04261-2
Xiaofeng Zhao, Liancheng Jia, Weiguang Li, Huichao Xu, Peng Ning, Nan Sha, Lei Zhang

To compare the efficacy and safety of low-power holmium laser enucleation of the prostate (LP-HoLEP) with plasma kinetic resection of prostate (PKRP). Sixty-three patients treated with transurethral LP-HoLEP (observation group) and 68 patients treated with transurethral PKRP (control group) at Beijing Hospital of Traditional Chinese Medicine from November 2019 to November 2022 were retrospectively compared with regard to operation duration, intra-operative blood loss, prostate resection ratio, postoperative bladder irrigation time, postoperative indwelling urinary catheter time, postoperative urinary incontinence incidence, International Prostate Symptom Scale (IPSS), maximum urine flow rate (Qmax), and residual urine volume (RUV). In both groups, postoperative IPSS, Qmax, and RUV were significantly improved compared to preoperative values (P < 0.05). Comparing the observation group to the control group, the intra-operative blood loss were (59.6 ± 18.1) and (173.1 ± 85.3) ml, respectively (t = -10.350, P < 0.01); the prostate resection ratios were (81.2 ± 4.6) % and (56.7 ± 9.7)%, respectively (t = 18.230, P < 0.01); the postoperative bladder irrigation time was (39.1 ± 9.6) h and (49.7 ± 6.0) h, respectively (t = -7.623, P < 0.01); and the postoperative indwelling urinary catheter time was (111.5 ± 19.4) h and (120.4 ± 12.8) h, respectively (t = -3.125, P < 0.01). Comparing the observation group to the control group, the operation duration was (76.2 ± 18.6) and (83.0 ± 32.4) min, respectively, with no statistical difference (t = -1.226, P = 0.208); the postoperative urinary incontinence incidence was 12.7% and 8.8%, respectively and there was no statistical difference (χ² = 0.514, P = 0.473). LP-HoLEP offers excellent surgical efficacy and safety. LP-HoLEP is superior to PKRP in intra-operative blood loss, postoperative bladder irrigation time, and postoperative indwelling urinary catheter time, and can enucleate more hyperplastic glands.

比较低功率钬激光前列腺去核术(LP-HoLEP)与等离子动力前列腺切除术(PKRP)的疗效和安全性。回顾性比较2019年11月至2022年11月北京中医医院经尿道LP-HoLEP治疗的63例患者(观察组)和经尿道PKRP治疗的68例患者(对照组)的手术时间、术中出血量、前列腺切除率、术后膀胱冲洗时间、术后留置导尿管时间、术后尿失禁发生率、国际前列腺症状量表(IPSS)、最大尿流率(Qmax)、剩余尿量(RUV)。两组患者术后IPSS、Qmax、RUV较术前均有显著改善(P
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引用次数: 0
Fractional 1064 nm Nd: YAG picosecond lasers for the treatment of traumatic scars: a retrospective study. 分数1064 nm Nd: YAG皮秒激光治疗创伤性疤痕的回顾性研究。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-28 DOI: 10.1007/s10103-024-04247-0
Jiaxuan Jin, Hedan Yang, Hui Ding, Huiying Zheng, Xiaoli Zhang, Yiping Ge, Yin Yang, Tong Lin

Traumatic scars negatively impact the patient's quality of life. Fractional 1064 nm Nd: YAG picosecond laser improves scars. However, the effect varies among individuals. This study aimed to evaluate the treatment of traumatic scars with fractional 1064 nm Nd: YAG picosecond lasers and the factors associated with its prognostication. We conducted a retrospective study with 161 patients with traumatic scars. All scars were treated using fractional 1064 nm Nd: YAG picosecond lasers. Efficacy was determined based on blinded visual evaluation using the Manchester Scar Scale (MSS) and 5-point Global Assessment Scale (GAS). The mean MSS values before and after treatments was 17.4 ± 2.7 and 13.6 ± 2.6 (P < 0.001), respectively. Color, radiance, contour, and distortion of the traumatic scars improved. (all P < 0.001). The course, location, and height of the scars, and the number of treatments and energy densities, were related to treatment responses (P < 0.05). Fractional 1064 nm Nd: YAG picosecond laser is effective for treating traumatic scars. Clinicians can predict the prognosis using multiple factors.

创伤性疤痕会对患者的生活质量产生负面影响。分数1064 nm Nd: YAG皮秒激光改善疤痕。然而,影响因人而异。本研究旨在评价分数阶1064 nm Nd: YAG皮秒激光治疗创伤性疤痕的效果及其预后的相关因素。我们对161例创伤性瘢痕患者进行了回顾性研究。所有疤痕均采用分数1064 nm Nd: YAG皮秒激光治疗。采用曼彻斯特疤痕量表(MSS)和5分全球评估量表(GAS)进行盲法视觉评价,确定疗效。治疗前后平均MSS分别为17.4±2.7和13.6±2.6 (P < 0.05)
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引用次数: 0
Gingival crevicular fluid level of tumor necrosis factor-alpha as a valuable biomarker for estimation of the efficacy of adjunctive antimicrobial photodynamic therapy in stage II-IV periodontitis: a systematic review and meta-analysis. 牙龈沟液肿瘤坏死因子- α水平作为评估II-IV期牙周炎辅助抗菌光动力治疗疗效的有价值的生物标志物:一项系统综述和荟萃分析。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-22 DOI: 10.1007/s10103-024-04251-4
Malihe Karrabi, Zahra Baghani, Hossein Assarzadeh

Purpose: This systematic review and meta-analysis aimed to assess the gingival crevicular fluid (GCF) level of tumor necrosis factor-alpha (TNF-alpha) as a valuable inflammatory cytokine for estimation of the efficacy of adjunctive antimicrobial photodynamic therapy (aPDT) in stage II-IV periodontitis patients.

Methods: This review was conducted in accordance with the PRISMA statements, and registered in PROSPERO (CRD42022321211). An electronic search was conducted for articles comparing the efficacy of aPDT versus scaling and root planing (SRP) published up until June 2023. The mean GCF level of TNF-alpha and clinical attachment loss (CAL) with 95% confidence interval (CI) were pooled and compared between the groups using a random-effect model after 1-2, 4-5, 12-13, and ≥ 24 weeks. The I2 test was applied to assess the heterogeneity of the findings, and publication bias was evaluated by visual inspection of the funnel plot symmetry.

Results: Analysis of 11 studies indicated a significant difference in GCF level of TNF-alpha at the 1-2, 12-13 and ≥ 24-week follow-ups in patients treated with aPDT + SRP. However, at the 4-5-week follow-up, the results were significant in favor of the control group (mean difference = -0.17, 95% CI = -1.86-152, P < 0.00001).

Conclusion: Despite the limitations of the included studies, aPDT can decrease the GCF level of TNF-alpha inflammatory biomarker for a longer period of time than SRP alone in grade II-IV periodontitis. However, further investigations are required to assess the efficacy of higher frequency of aPDT applications.

目的:本系统综述和荟萃分析旨在评估牙龈沟液(GCF)中肿瘤坏死因子- α (tnf - α)的水平,作为评估II-IV期牙周炎患者辅助抗菌光动力治疗(aPDT)疗效的一种有价值的炎症细胞因子。方法:本综述按照PRISMA声明进行,并在PROSPERO注册(CRD42022321211)。电子检索了截至2023年6月发表的比较aPDT与除垢和根系规划(SRP)功效的文章。采用随机效应模型,对各组在1-2、4-5、12-13和≥24周后tnf - α的平均GCF水平和临床依恋丧失(CAL)的95%置信区间(CI)进行汇总和比较。采用I2检验来评估研究结果的异质性,并通过视觉检查漏斗图对称性来评估发表偏倚。结果:11项研究的分析显示,aPDT + SRP治疗患者在随访1-2周、12-13周和≥24周时,tnf - α的GCF水平有显著差异。然而,在4-5周的随访中,结果明显有利于对照组(平均差异= -0.17,95% CI = -1.86-152, P)。结论:尽管纳入的研究存在局限性,但在II-IV级牙周炎中,aPDT比单独使用SRP更能降低tnf - α炎症生物标志物的GCF水平。然而,需要进一步的调查来评估更高频率aPDT应用的效果。
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引用次数: 0
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Lasers in Medical Science
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