Pub Date : 2024-12-20DOI: 10.1007/s10103-024-04264-z
Maria Clara Oliveira, Diego Filipe Bezerra Silva, Allany de Oliveira Andrade, Daniela Pita de Melo, Ygor Alexandre Beserra de Sousa, Luís Otávio Pereira da Silva, Daliana Queiroga de Castro Gomes
The aim of this study was to investigate the scientific evidence regarding the effectiveness of modified-ILIB (intravascular laser irradiation of blood) in the control of systemic conditions and/or oral changes during dental care. This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control of systemic conditions and/or oral changes in children and adults during dental treatment?". The protocol for this systematic review was registered in the PROSPERO database under number CRD42023493800. The search was carried out in the PubMed, Web of Science, LILACS, SCOPUS and EMBASE databases on June 10, 2024. Google Scholar was used as a search source for gray literature. Randomized clinical trials were included, without restrictions on language or year of publication. The RoB 2.0 tool was used to assess the risk of bias and GRADE was used to check the quality of the evidence. A total of 750 articles were retrieved and five studies were selected for this review. All studies were in English and were carried out in Brazil. The outcomes were periodontal parameters and glycemic control in patients with periodontitis and type II diabetes, anxiety control in pediatric dentistry, postoperative pain after third molar extraction and improving taste in post-COVID-19 patients. The majority of studies had a low risk of bias, while only one study was considered to have some concerns. The quality of evidence from the studies was considered very low. The current evidence does not overwhelmingly support the effectiveness of modified-ILIB in controlling oral and/or systemic conditions in dentistry.
本研究的目的是调查改良的血管内激光血液照射在控制牙齿护理期间的全身状况和/或口腔变化方面的有效性的科学证据。本系统的文献综述研究旨在回答以下问题:“在儿童和成人的牙科治疗过程中,改良的ilib是控制全身状况和/或口腔变化的有效辅助疗法吗?”该系统评价的方案已在PROSPERO数据库中注册,编号为CRD42023493800。检索于2024年6月10日在PubMed、Web of Science、LILACS、SCOPUS和EMBASE数据库中进行。使用谷歌Scholar作为灰色文献的搜索源。纳入随机临床试验,不受语言或发表年份的限制。使用RoB 2.0工具评估偏倚风险,使用GRADE检查证据质量。共检索到750篇文献,其中5项研究入选本综述。所有研究均以英文进行,并在巴西进行。结果是牙周炎和II型糖尿病患者的牙周参数和血糖控制,儿童牙科患者的焦虑控制,第三磨牙拔牙术后疼痛和covid -19后患者的味觉改善。大多数研究具有低偏倚风险,而只有一项研究被认为存在一些问题。这些研究的证据质量被认为非常低。目前的证据并不压倒性地支持改良的ilib在控制口腔和/或口腔系统疾病方面的有效性。
{"title":"Effect of modified intravascular laser irradiation of blood in the oral and systemic conditions during dental treatment-A systematic review.","authors":"Maria Clara Oliveira, Diego Filipe Bezerra Silva, Allany de Oliveira Andrade, Daniela Pita de Melo, Ygor Alexandre Beserra de Sousa, Luís Otávio Pereira da Silva, Daliana Queiroga de Castro Gomes","doi":"10.1007/s10103-024-04264-z","DOIUrl":"https://doi.org/10.1007/s10103-024-04264-z","url":null,"abstract":"<p><p>The aim of this study was to investigate the scientific evidence regarding the effectiveness of modified-ILIB (intravascular laser irradiation of blood) in the control of systemic conditions and/or oral changes during dental care. This systematic literature review study aimed to answer the question, \"Is modified-ILIB an effective adjuvant therapy in the control of systemic conditions and/or oral changes in children and adults during dental treatment?\". The protocol for this systematic review was registered in the PROSPERO database under number CRD42023493800. The search was carried out in the PubMed, Web of Science, LILACS, SCOPUS and EMBASE databases on June 10, 2024. Google Scholar was used as a search source for gray literature. Randomized clinical trials were included, without restrictions on language or year of publication. The RoB 2.0 tool was used to assess the risk of bias and GRADE was used to check the quality of the evidence. A total of 750 articles were retrieved and five studies were selected for this review. All studies were in English and were carried out in Brazil. The outcomes were periodontal parameters and glycemic control in patients with periodontitis and type II diabetes, anxiety control in pediatric dentistry, postoperative pain after third molar extraction and improving taste in post-COVID-19 patients. The majority of studies had a low risk of bias, while only one study was considered to have some concerns. The quality of evidence from the studies was considered very low. The current evidence does not overwhelmingly support the effectiveness of modified-ILIB in controlling oral and/or systemic conditions in dentistry.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"300"},"PeriodicalIF":2.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-18DOI: 10.1007/s10103-024-04257-y
Maarten Meire, Ben van Aelst, Aldin Sehovic, Shengjile Deari, Matthias Zehnder
Laser-activated irrigation (LAI) of root canal systems depends on the generation of cavitation bubbles in the endodontic irrigant. Physical studies thus far focused on pulse energy, pulse length, frequency, and fiber tip shape, mostly in plain water. This study investigated the effect of endodontically relevant molecules (sodium hypochlorite (NaOCl), 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and their combination) in water on physical properties of the resulting solution, and their impact on primary cavitation bubble features. A commercially available 3% NaOCl irrigant was used, as well as an etidronate powder (Dual Rinse HEDP) to be admixed. Physical parameters (density, surface tension, and viscosity) of these solutions were assessed, including HEDP effects in an ascending concentration series of up to 20%. Primary cavitation bubble features (dimensional and temporal) in conjunction with a pulsed erbium-doped yttrium aluminium garnet (Er: YAG) laser equipped with a flat or conical fiber tip were studied in these liquids using a high-speed camera. Solutes increased the solution's density, surface tension, and viscosity, with an almost linear response to HEDP dosage (Pearson correlation coefficient > 0.95). This reduced the speed of the primary cavitation bubble, and increased its size and lifetime. Increased HEDP concentrations had a pronounced effect on the shape of bubbles generated at the flat tip. NaOCl and HEDP alter the physical properties of water, which, in turn, affect its cavitation behavior.
{"title":"Solutes in water affect the primary cavitation bubble generated by a pulsed erbium-doped yttrium aluminium garnet laser.","authors":"Maarten Meire, Ben van Aelst, Aldin Sehovic, Shengjile Deari, Matthias Zehnder","doi":"10.1007/s10103-024-04257-y","DOIUrl":"10.1007/s10103-024-04257-y","url":null,"abstract":"<p><p>Laser-activated irrigation (LAI) of root canal systems depends on the generation of cavitation bubbles in the endodontic irrigant. Physical studies thus far focused on pulse energy, pulse length, frequency, and fiber tip shape, mostly in plain water. This study investigated the effect of endodontically relevant molecules (sodium hypochlorite (NaOCl), 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and their combination) in water on physical properties of the resulting solution, and their impact on primary cavitation bubble features. A commercially available 3% NaOCl irrigant was used, as well as an etidronate powder (Dual Rinse HEDP) to be admixed. Physical parameters (density, surface tension, and viscosity) of these solutions were assessed, including HEDP effects in an ascending concentration series of up to 20%. Primary cavitation bubble features (dimensional and temporal) in conjunction with a pulsed erbium-doped yttrium aluminium garnet (Er: YAG) laser equipped with a flat or conical fiber tip were studied in these liquids using a high-speed camera. Solutes increased the solution's density, surface tension, and viscosity, with an almost linear response to HEDP dosage (Pearson correlation coefficient > 0.95). This reduced the speed of the primary cavitation bubble, and increased its size and lifetime. Increased HEDP concentrations had a pronounced effect on the shape of bubbles generated at the flat tip. NaOCl and HEDP alter the physical properties of water, which, in turn, affect its cavitation behavior.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"298"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652422/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-18DOI: 10.1007/s10103-024-04061-8
Arie Y Nemet, Efrat Solomon-Cohen, Anna Aronovich, Malachy Nemet, Daniel Hilewitz, Achia Nemet, Kaplan Baruch, Lehavit Akerman
To determine in which cases ablative radiofrequency microplasma is preferred for the treatment of lateral dermatochalasis over a surgical approach as well as discussing each method's benefits and limitations. Twenty-one patients underwent 3 interventions of plasma exeresis. Photographic and RCM images were acquired at baseline and 4 weeks after final plasma exeresis. The eyes were categorized into 3 groups based on the dermatochalasis severity (1- mild, 2- moderate, 3- severe). Additionally, a further division was conducted to assess the degree of enhancement observed after the treatment (1- slight improvement, 2- moderate improvement, 3- significant improvement). The classifications and assessments were performed by was graded by two trained dermatologists as blinded observers. A total of 21 eyes with a mean age of 54 years (range45-67 years) and 100% females were included in this study. The severity of dermatochalasis directly affects the clinical improvement (P=0.039) and the higher the severity, the more the improvement (R = -0.62). Noninvasive ablative microplasma may offer safe and effective therapy for upper eyelid dermatochalasis and can even be performed in patients at surgical risk. However, it may be suitable for grades 0 and 1 of DC. For more advanced grades a surgical solution achieves better results for the treatment of dermatochalasis of the upper eyelid.
{"title":"Ablative radiofrequency microplasma for lateral dermatochalasis-indications and treatment recommendations.","authors":"Arie Y Nemet, Efrat Solomon-Cohen, Anna Aronovich, Malachy Nemet, Daniel Hilewitz, Achia Nemet, Kaplan Baruch, Lehavit Akerman","doi":"10.1007/s10103-024-04061-8","DOIUrl":"10.1007/s10103-024-04061-8","url":null,"abstract":"<p><p>To determine in which cases ablative radiofrequency microplasma is preferred for the treatment of lateral dermatochalasis over a surgical approach as well as discussing each method's benefits and limitations. Twenty-one patients underwent 3 interventions of plasma exeresis. Photographic and RCM images were acquired at baseline and 4 weeks after final plasma exeresis. The eyes were categorized into 3 groups based on the dermatochalasis severity (1- mild, 2- moderate, 3- severe). Additionally, a further division was conducted to assess the degree of enhancement observed after the treatment (1- slight improvement, 2- moderate improvement, 3- significant improvement). The classifications and assessments were performed by was graded by two trained dermatologists as blinded observers. A total of 21 eyes with a mean age of 54 years (range45-67 years) and 100% females were included in this study. The severity of dermatochalasis directly affects the clinical improvement (P=0.039) and the higher the severity, the more the improvement (R = -0.62). Noninvasive ablative microplasma may offer safe and effective therapy for upper eyelid dermatochalasis and can even be performed in patients at surgical risk. However, it may be suitable for grades 0 and 1 of DC. For more advanced grades a surgical solution achieves better results for the treatment of dermatochalasis of the upper eyelid.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"299"},"PeriodicalIF":2.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11655603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-17DOI: 10.1007/s10103-024-04255-0
Khwairakpam Shantakumar Singh, Thangjam Premabati
Simulation studies on temperature distribution in laser ablation help predict ablation rates, laser settings, and thermal damage. Despite the limited number of reported numerical studies on the temperature distribution of kidney fluid, there is no simulation study for kidney stone temperature distribution. We employ a numerical approach to study the kidney stone temperature distribution and predict ablation rates, which is an important parameter for clinical lithotripsy. The study looked at how the thulium fiber laser and the Ho:YAG laser differ in terms of temperature profile and ablation depth of kidney stones like calcium oxide monohydrate. The ablation depth increased from 152.7 µm to 489.7 µm when the TFL laser (operated at 10 Hz repetition rate and 1 ms pulse width) fluence increased from 764 J/cm2 to 1146 J/cm2. Correspondingly, the depth increased from 21 µm to 68 µm for the Ho: YAG laser operated at 3 Hz and 0.22 ms pulse width. We attribute this to an increase in temperature with laser energy. We further investigated the effect of pulse width on ablation depth by considering three different TFL pulse widths: 0.5 ms, 0.75 ms, and 1 ms. There was a decrease in ablation depths from 402.5 µm to 242.6 µm when the pulse width increased from 0.5 ms to 1 ms. Because of lower water absorption coefficients, the Ho:YAG laser (70 mJ/10 Hz) produced a smaller ablation depth and temperature profile than the thulium fiber laser (70 mJ/10 Hz). Experimental results from the literature validated the simulation. We found that the Ho:YAG laser worked better for ablation when it was set to 0.2 J/100 Hz for the Ho:YAG laser and 0.4 J/50 Hz for the TFL laser, which were clinical laser settings that we found in the literature. This indicates that, in addition to laser absorption by water, the laser parameters also significantly influence temperature distribution and ablation.
{"title":"Simulation of the temperature distribution of kidney stones induced by thulium fiber laser and Ho: YAG laser lithotripsy.","authors":"Khwairakpam Shantakumar Singh, Thangjam Premabati","doi":"10.1007/s10103-024-04255-0","DOIUrl":"https://doi.org/10.1007/s10103-024-04255-0","url":null,"abstract":"<p><p>Simulation studies on temperature distribution in laser ablation help predict ablation rates, laser settings, and thermal damage. Despite the limited number of reported numerical studies on the temperature distribution of kidney fluid, there is no simulation study for kidney stone temperature distribution. We employ a numerical approach to study the kidney stone temperature distribution and predict ablation rates, which is an important parameter for clinical lithotripsy. The study looked at how the thulium fiber laser and the Ho:YAG laser differ in terms of temperature profile and ablation depth of kidney stones like calcium oxide monohydrate. The ablation depth increased from 152.7 µm to 489.7 µm when the TFL laser (operated at 10 Hz repetition rate and 1 ms pulse width) fluence increased from 764 J/cm<sup>2</sup> to 1146 J/cm<sup>2</sup>. Correspondingly, the depth increased from 21 µm to 68 µm for the Ho: YAG laser operated at 3 Hz and 0.22 ms pulse width. We attribute this to an increase in temperature with laser energy. We further investigated the effect of pulse width on ablation depth by considering three different TFL pulse widths: 0.5 ms, 0.75 ms, and 1 ms. There was a decrease in ablation depths from 402.5 µm to 242.6 µm when the pulse width increased from 0.5 ms to 1 ms. Because of lower water absorption coefficients, the Ho:YAG laser (70 mJ/10 Hz) produced a smaller ablation depth and temperature profile than the thulium fiber laser (70 mJ/10 Hz). Experimental results from the literature validated the simulation. We found that the Ho:YAG laser worked better for ablation when it was set to 0.2 J/100 Hz for the Ho:YAG laser and 0.4 J/50 Hz for the TFL laser, which were clinical laser settings that we found in the literature. This indicates that, in addition to laser absorption by water, the laser parameters also significantly influence temperature distribution and ablation.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"297"},"PeriodicalIF":2.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142835975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This research was designed to study effects of high versus low-level laser therapy (HILT and LLLT) on post-dry needling soreness (PNS) at patients with chronic neck pain. We also studied effects of HLLT or LLLT application plus dry needling (DN) on pain, range of motion (ROM), and neck disability index (NDI) at the identified patients. This is a clinical trial in 48 women with chronic neck pain aged 18-35 who were divided into three groups: HLLT, LLLT, and placebo group. All the participants received one session of DN and laser therapy. The study assessed the soreness using Visual Analog Scale for needle pain (nVAS) and Pressure Pain Threshold (PPT) before, immediately after, 24 and 48 h after laser therapy. Pain, ROM, and NDI assessed before and also different time courses after DN plus laser therapy. PPT and nVAS improved in all groups over time. In the placebo group, nVAS increased significantly (p < 0.001) after treatment. VAS, NDI, and ROM improved 48 h after treatment in all groups. The VAS scores were substantially decreased (p < 0.001) immediately after treatment for LLLT group and also 24 h after treatment for both LLLT and HLLT groups. LLLT and HLLT might prevent immediately increasing the PNS. Adding one session of LLLT or HLLT to DN could effectively eliminate the neck pain at 24 h. All groups improved NDI and ROM the same. Registration number: IRCT20190411043241N1. Registered Sep 2, 2019.
{"title":"Effects of high and low level lasers on soreness following dry needling in patients with chronic myofascial neck pain. A randomized-controlled trial.","authors":"Maryam Motavalian, Siamak Bashardoust Tajali, Behrouz Attarbashi Moghadam, Seyedeh Zohreh Hosseini","doi":"10.1007/s10103-024-04201-0","DOIUrl":"10.1007/s10103-024-04201-0","url":null,"abstract":"<p><p>This research was designed to study effects of high versus low-level laser therapy (HILT and LLLT) on post-dry needling soreness (PNS) at patients with chronic neck pain. We also studied effects of HLLT or LLLT application plus dry needling (DN) on pain, range of motion (ROM), and neck disability index (NDI) at the identified patients. This is a clinical trial in 48 women with chronic neck pain aged 18-35 who were divided into three groups: HLLT, LLLT, and placebo group. All the participants received one session of DN and laser therapy. The study assessed the soreness using Visual Analog Scale for needle pain (nVAS) and Pressure Pain Threshold (PPT) before, immediately after, 24 and 48 h after laser therapy. Pain, ROM, and NDI assessed before and also different time courses after DN plus laser therapy. PPT and nVAS improved in all groups over time. In the placebo group, nVAS increased significantly (p < 0.001) after treatment. VAS, NDI, and ROM improved 48 h after treatment in all groups. The VAS scores were substantially decreased (p < 0.001) immediately after treatment for LLLT group and also 24 h after treatment for both LLLT and HLLT groups. LLLT and HLLT might prevent immediately increasing the PNS. Adding one session of LLLT or HLLT to DN could effectively eliminate the neck pain at 24 h. All groups improved NDI and ROM the same. Registration number: IRCT20190411043241N1. Registered Sep 2, 2019.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"296"},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Excimer laser coronary angioplasty (ELCA) in percutaneous coronary intervention (PCI) is safe and effective. However, thrombotic complications after ELCA occasionally occur. This study aimed to evaluate the impact of lipid-rich plaque in both in-stent restenosis (ISR) and de novo lesions on thrombus formation and transient no-reflow after ELCA. We conducted a single-center, retrospective, observational study including 27 lesions in 26 patients who underwent PCI with ELCA. Optical coherence tomography (OCT) was performed on all lesions before and immediately after ELCA. We measured the lipid angle per millimeter and lipid length of plaques with signal attenuation. We also recorded ELCA-induced thrombus formation and transient no-reflow. Thrombus formation and transient no-reflow were observed in nine (33%) and four lesions (15%), respectively. The frequency of ISR was significantly higher in the no-thrombus group than in the thrombus group. ISR lesions had a significantly lower lipid index (median [interquartile range] 108° [0°-756°] vs. 2541° [1205°-4336°]; p = 0.004) than de novo lesions. Among ISR lesions, those with ELCA-induced thrombus formation had a significantly higher lipid index (1370° [756°-4992°] vs. 29° [0°-285°]; p = 0.01) and significantly longer lipid length (8 mm [7-24 mm] vs. 0.5 mm [0-2.5 mm]; p = 0.01). The findings suggest that thrombus formation was more frequently observed in de novo lesions than in ISR lesions. OCT-detected lipid-rich plaques in ISR lesions were strongly associated with thrombus formation following ELCA.
经皮冠状动脉介入治疗(PCI)中的准分子激光冠状动脉血管成形术(ELCA)安全有效。然而,ELCA术后偶尔会出现血栓并发症。本研究旨在评估支架内再狭窄(ISR)和新生病变中的富脂斑块对 ELCA 术后血栓形成和一过性无血流的影响。我们进行了一项单中心、回顾性、观察性研究,研究对象包括 26 名接受 PCI 和 ELCA 的患者中的 27 个病变。在 ELCA 之前和之后立即对所有病灶进行了光学相干断层扫描 (OCT)。我们测量了有信号衰减的斑块的每毫米脂质角和脂质长度。我们还记录了 ELCA 诱导的血栓形成和一过性无回流。我们分别在9个病变(33%)和4个病变(15%)中观察到血栓形成和短暂的无回流。无血栓组发生 ISR 的频率明显高于血栓组。ISR病变的血脂指数(中位数[四分位间范围] 108° [0°-756°] vs. 2541° [1205°-4336°]; p = 0.004)明显低于新生病变。在 ISR 病变中,ELCA 诱导血栓形成的病变脂质指数明显更高(1370° [756°-4992°] vs. 29° [0°-285°];p = 0.01),脂质长度明显更长(8 mm [7-24 mm] vs. 0.5 mm [0-2.5 mm];p = 0.01)。研究结果表明,与 ISR 病变相比,血栓形成在新发病变中更为常见。在ISR病变中,OCT检测到的富脂斑块与ELCA后的血栓形成密切相关。
{"title":"Association between lipid-rich plaques and thrombus formation after excimer laser coronary angioplasty in in-stent restenosis and de novo lesions.","authors":"Takayuki Nakano, Hiroki Ikenaga, Atsushi Takeda, Yuichi Morita, Tasuku Higashihara, Noriaki Watanabe, Yoshiharu Sada, Yukiko Nakano","doi":"10.1007/s10103-024-04265-y","DOIUrl":"10.1007/s10103-024-04265-y","url":null,"abstract":"<p><p>Excimer laser coronary angioplasty (ELCA) in percutaneous coronary intervention (PCI) is safe and effective. However, thrombotic complications after ELCA occasionally occur. This study aimed to evaluate the impact of lipid-rich plaque in both in-stent restenosis (ISR) and de novo lesions on thrombus formation and transient no-reflow after ELCA. We conducted a single-center, retrospective, observational study including 27 lesions in 26 patients who underwent PCI with ELCA. Optical coherence tomography (OCT) was performed on all lesions before and immediately after ELCA. We measured the lipid angle per millimeter and lipid length of plaques with signal attenuation. We also recorded ELCA-induced thrombus formation and transient no-reflow. Thrombus formation and transient no-reflow were observed in nine (33%) and four lesions (15%), respectively. The frequency of ISR was significantly higher in the no-thrombus group than in the thrombus group. ISR lesions had a significantly lower lipid index (median [interquartile range] 108° [0°-756°] vs. 2541° [1205°-4336°]; p = 0.004) than de novo lesions. Among ISR lesions, those with ELCA-induced thrombus formation had a significantly higher lipid index (1370° [756°-4992°] vs. 29° [0°-285°]; p = 0.01) and significantly longer lipid length (8 mm [7-24 mm] vs. 0.5 mm [0-2.5 mm]; p = 0.01). The findings suggest that thrombus formation was more frequently observed in de novo lesions than in ISR lesions. OCT-detected lipid-rich plaques in ISR lesions were strongly associated with thrombus formation following ELCA.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"295"},"PeriodicalIF":2.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-15DOI: 10.1007/s10103-024-04252-3
Karin R Pillunat, Florian T A Kretz, Stefan Koinzer, Philipp Müller, Lutz E Pillunat, Karsten Klabe
To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS® green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS® green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat - mITT -group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (p < 0.0001): 52.6% had ≥ 20% IOP reduction at 12 months. Potential device- or procedure-related adverse events were mild to moderate and resolved without sequelae. SLT performed with the VISULAS® green laser reduced IOP in eyes with POAG up to 12 months with no relevant safety issues. The results are comparable to other reported SLT studies.
{"title":"Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data.","authors":"Karin R Pillunat, Florian T A Kretz, Stefan Koinzer, Philipp Müller, Lutz E Pillunat, Karsten Klabe","doi":"10.1007/s10103-024-04252-3","DOIUrl":"10.1007/s10103-024-04252-3","url":null,"abstract":"<p><p>To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS<sup>®</sup> green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS<sup>®</sup> green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat - mITT -group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (p < 0.0001): 52.6% had ≥ 20% IOP reduction at 12 months. Potential device- or procedure-related adverse events were mild to moderate and resolved without sequelae. SLT performed with the VISULAS<sup>®</sup> green laser reduced IOP in eyes with POAG up to 12 months with no relevant safety issues. The results are comparable to other reported SLT studies.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"293"},"PeriodicalIF":2.1,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-12DOI: 10.1007/s10103-024-04250-5
Maria Luiza Costabeber Perin, Letícia Souza Mata da Silva, Maysa Lannes Duarte, Laura Guimarães Primo
The objective of this study was to identify, describe and synthesize the data published about the effectiveness of antimicrobial photodynamic therapy (aPDT) in the pulpectomy of primary teeth. A search was conducted in six electronic databases and the gray literature in June and July 2023, without restrictions on language or date of publication. The search strategy included indexed terms (MeSH terms) and your synonyms. Clinical trials, in vitro studies, case reports and retrospective studies that used photodynamic therapy in primary teeth pulpectomies were considered eligible. Among the 1,674 articles retrieved, 15 were included, published between 2014 and 2022, comprising six in vitro studies, five clinical trials, and four case reports. The sample consisted of children aged 2 to 8 years of both sexes, and included 1 to 62 teeth, mostly anterior. In two in vitro studies, the sample was taken from root canals. Most studies used a diode laser, methylene blue, and optical fiber. The pre-irradiation time ranged from 1 to 5 min. All protocols demonstrated microbial reduction before and after using aPDT, with no statistical difference among the groups. Furthermore, six studies demonstrated treatment success. Despite the divergence in methodology and protocols, aPDT is an effective method for reducing microorganisms, and is a promising adjunct treatment in primary teeth pulpectomies.
{"title":"Efficacy of antimicrobial photodynamic therapy in endodontics of primary teeth: a scoping review.","authors":"Maria Luiza Costabeber Perin, Letícia Souza Mata da Silva, Maysa Lannes Duarte, Laura Guimarães Primo","doi":"10.1007/s10103-024-04250-5","DOIUrl":"10.1007/s10103-024-04250-5","url":null,"abstract":"<p><p>The objective of this study was to identify, describe and synthesize the data published about the effectiveness of antimicrobial photodynamic therapy (aPDT) in the pulpectomy of primary teeth. A search was conducted in six electronic databases and the gray literature in June and July 2023, without restrictions on language or date of publication. The search strategy included indexed terms (MeSH terms) and your synonyms. Clinical trials, in vitro studies, case reports and retrospective studies that used photodynamic therapy in primary teeth pulpectomies were considered eligible. Among the 1,674 articles retrieved, 15 were included, published between 2014 and 2022, comprising six in vitro studies, five clinical trials, and four case reports. The sample consisted of children aged 2 to 8 years of both sexes, and included 1 to 62 teeth, mostly anterior. In two in vitro studies, the sample was taken from root canals. Most studies used a diode laser, methylene blue, and optical fiber. The pre-irradiation time ranged from 1 to 5 min. All protocols demonstrated microbial reduction before and after using aPDT, with no statistical difference among the groups. Furthermore, six studies demonstrated treatment success. Despite the divergence in methodology and protocols, aPDT is an effective method for reducing microorganisms, and is a promising adjunct treatment in primary teeth pulpectomies.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"292"},"PeriodicalIF":2.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Neck pain is considered one of the most prevalent global public health problems. This study aimed to compare the immediate and subsequent effects of traditional acupuncture (TA) and laser acupuncture (LA) therapies in individuals with chronic non-specific neck pain. Eighty-four individuals were randomly allocated into 3 groups: TA (needle acupuncture treatment), LA (laser acupuncture treatment: 808 nm; 100 mW; 10 J per point), and S-LA (sham laser acupuncture). The participants were men and women aged between 18 and 60 years who had experienced chronic non-specific neck pain for a minimum period of 3 months. The Tianzhu, Fengchi, Jianjing, and Jianzhongshu acupuncture points were stimulated bilaterally. The primary outcomes were pain intensities at rest and during active neck movements, assessed using the Numerical Rating Scale. The secondary outcomes were Pressure Pain Threshold, Temporal Summation of pain, Conditioned Pain Modulation, and Global Perceived Effect scale. The assessments were performed immediately before and after a single treatment session. Additionally, determinations of pain intensity at rest and Global Perceived Effect were performed in a follow-up assessment one month after the interventions. The results showed that the TA and LA interventions were equally significantly superior in reducing immediate pain compared to placebo laser acupuncture (p = 0.001). Traditional acupuncture and laser acupuncture provided equally effective reductions of pain intensity in patients with chronic non-specific neck pain. Clinical Trial registration: RBR-7vbw5gd (Brazilian Registry of Clinical Trials - ReBEC).
{"title":"Immediate effects of traditional and laser acupuncture in chronic non-specific neck pain: a randomized controlled clinical trial.","authors":"Rafaela Peron, Cláudio Gregório Nuernberg Back, Érika Patrícia Rampazo, Milene Branco, Cleber Ferraresi, Richard Eloin Liebano","doi":"10.1007/s10103-024-04235-4","DOIUrl":"10.1007/s10103-024-04235-4","url":null,"abstract":"<p><p>Neck pain is considered one of the most prevalent global public health problems. This study aimed to compare the immediate and subsequent effects of traditional acupuncture (TA) and laser acupuncture (LA) therapies in individuals with chronic non-specific neck pain. Eighty-four individuals were randomly allocated into 3 groups: TA (needle acupuncture treatment), LA (laser acupuncture treatment: 808 nm; 100 mW; 10 J per point), and S-LA (sham laser acupuncture). The participants were men and women aged between 18 and 60 years who had experienced chronic non-specific neck pain for a minimum period of 3 months. The Tianzhu, Fengchi, Jianjing, and Jianzhongshu acupuncture points were stimulated bilaterally. The primary outcomes were pain intensities at rest and during active neck movements, assessed using the Numerical Rating Scale. The secondary outcomes were Pressure Pain Threshold, Temporal Summation of pain, Conditioned Pain Modulation, and Global Perceived Effect scale. The assessments were performed immediately before and after a single treatment session. Additionally, determinations of pain intensity at rest and Global Perceived Effect were performed in a follow-up assessment one month after the interventions. The results showed that the TA and LA interventions were equally significantly superior in reducing immediate pain compared to placebo laser acupuncture (p = 0.001). Traditional acupuncture and laser acupuncture provided equally effective reductions of pain intensity in patients with chronic non-specific neck pain. Clinical Trial registration: RBR-7vbw5gd (Brazilian Registry of Clinical Trials - ReBEC).</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"39 1","pages":"291"},"PeriodicalIF":2.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}