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Effect of modified intravascular laser irradiation of blood in the oral and systemic conditions during dental treatment-A systematic review. 改良血管内激光血液照射对口腔和全身治疗的影响——系统综述。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-20 DOI: 10.1007/s10103-024-04264-z
Maria Clara Oliveira, Diego Filipe Bezerra Silva, Allany de Oliveira Andrade, Daniela Pita de Melo, Ygor Alexandre Beserra de Sousa, Luís Otávio Pereira da Silva, Daliana Queiroga de Castro Gomes

The aim of this study was to investigate the scientific evidence regarding the effectiveness of modified-ILIB (intravascular laser irradiation of blood) in the control of systemic conditions and/or oral changes during dental care. This systematic literature review study aimed to answer the question, "Is modified-ILIB an effective adjuvant therapy in the control of systemic conditions and/or oral changes in children and adults during dental treatment?". The protocol for this systematic review was registered in the PROSPERO database under number CRD42023493800. The search was carried out in the PubMed, Web of Science, LILACS, SCOPUS and EMBASE databases on June 10, 2024. Google Scholar was used as a search source for gray literature. Randomized clinical trials were included, without restrictions on language or year of publication. The RoB 2.0 tool was used to assess the risk of bias and GRADE was used to check the quality of the evidence. A total of 750 articles were retrieved and five studies were selected for this review. All studies were in English and were carried out in Brazil. The outcomes were periodontal parameters and glycemic control in patients with periodontitis and type II diabetes, anxiety control in pediatric dentistry, postoperative pain after third molar extraction and improving taste in post-COVID-19 patients. The majority of studies had a low risk of bias, while only one study was considered to have some concerns. The quality of evidence from the studies was considered very low. The current evidence does not overwhelmingly support the effectiveness of modified-ILIB in controlling oral and/or systemic conditions in dentistry.

本研究的目的是调查改良的血管内激光血液照射在控制牙齿护理期间的全身状况和/或口腔变化方面的有效性的科学证据。本系统的文献综述研究旨在回答以下问题:“在儿童和成人的牙科治疗过程中,改良的ilib是控制全身状况和/或口腔变化的有效辅助疗法吗?”该系统评价的方案已在PROSPERO数据库中注册,编号为CRD42023493800。检索于2024年6月10日在PubMed、Web of Science、LILACS、SCOPUS和EMBASE数据库中进行。使用谷歌Scholar作为灰色文献的搜索源。纳入随机临床试验,不受语言或发表年份的限制。使用RoB 2.0工具评估偏倚风险,使用GRADE检查证据质量。共检索到750篇文献,其中5项研究入选本综述。所有研究均以英文进行,并在巴西进行。结果是牙周炎和II型糖尿病患者的牙周参数和血糖控制,儿童牙科患者的焦虑控制,第三磨牙拔牙术后疼痛和covid -19后患者的味觉改善。大多数研究具有低偏倚风险,而只有一项研究被认为存在一些问题。这些研究的证据质量被认为非常低。目前的证据并不压倒性地支持改良的ilib在控制口腔和/或口腔系统疾病方面的有效性。
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引用次数: 0
Solutes in water affect the primary cavitation bubble generated by a pulsed erbium-doped yttrium aluminium garnet laser. 水中的溶质会影响脉冲掺铒钇铝石榴石激光器产生的初级空化气泡。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-18 DOI: 10.1007/s10103-024-04257-y
Maarten Meire, Ben van Aelst, Aldin Sehovic, Shengjile Deari, Matthias Zehnder

Laser-activated irrigation (LAI) of root canal systems depends on the generation of cavitation bubbles in the endodontic irrigant. Physical studies thus far focused on pulse energy, pulse length, frequency, and fiber tip shape, mostly in plain water. This study investigated the effect of endodontically relevant molecules (sodium hypochlorite (NaOCl), 1-hydroxyethylidene-1,1-diphosphonic acid (HEDP), and their combination) in water on physical properties of the resulting solution, and their impact on primary cavitation bubble features. A commercially available 3% NaOCl irrigant was used, as well as an etidronate powder (Dual Rinse HEDP) to be admixed. Physical parameters (density, surface tension, and viscosity) of these solutions were assessed, including HEDP effects in an ascending concentration series of up to 20%. Primary cavitation bubble features (dimensional and temporal) in conjunction with a pulsed erbium-doped yttrium aluminium garnet (Er: YAG) laser equipped with a flat or conical fiber tip were studied in these liquids using a high-speed camera. Solutes increased the solution's density, surface tension, and viscosity, with an almost linear response to HEDP dosage (Pearson correlation coefficient > 0.95). This reduced the speed of the primary cavitation bubble, and increased its size and lifetime. Increased HEDP concentrations had a pronounced effect on the shape of bubbles generated at the flat tip. NaOCl and HEDP alter the physical properties of water, which, in turn, affect its cavitation behavior.

激光激活根管系统灌洗(LAI)依赖于根管灌洗剂中空化泡的产生。迄今为止,物理研究主要集中在脉冲能量、脉冲长度、频率和纤维尖端形状上,主要是在清水中进行的。本研究考察了水中根管相关分子(次氯酸钠(NaOCl)、1-羟乙基二膦酸(HEDP)及其组合)对溶液物理性质的影响,以及它们对初级空化泡特征的影响。使用市售的3% NaOCl冲洗剂,以及混合的依地膦酸盐粉末(双重冲洗HEDP)。评估了这些溶液的物理参数(密度、表面张力和粘度),包括HEDP在浓度上升至20%时的效果。利用高速摄像机研究了在这些液体中,与配备扁平或锥形光纤尖端的脉冲掺铒钇铝石榴石(Er: YAG)激光器相结合的初级空化气泡特征(尺寸和时间)。溶质增加了溶液的密度、表面张力和粘度,与HEDP用量几乎呈线性关系(Pearson相关系数> 0.95)。这降低了初级空化泡的速度,增加了它的尺寸和寿命。增加的HEDP浓度对扁平尖端产生的气泡形状有明显的影响。NaOCl和HEDP改变了水的物理性质,从而影响了水的空化行为。
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引用次数: 0
Ablative radiofrequency microplasma for lateral dermatochalasis-indications and treatment recommendations. 消融射频微血浆治疗外侧皮肤松弛症的适应症和治疗建议。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-18 DOI: 10.1007/s10103-024-04061-8
Arie Y Nemet, Efrat Solomon-Cohen, Anna Aronovich, Malachy Nemet, Daniel Hilewitz, Achia Nemet, Kaplan Baruch, Lehavit Akerman

To determine in which cases ablative radiofrequency microplasma is preferred for the treatment of lateral dermatochalasis over a surgical approach as well as discussing each method's benefits and limitations. Twenty-one patients underwent 3 interventions of plasma exeresis. Photographic and RCM images were acquired at baseline and 4 weeks after final plasma exeresis. The eyes were categorized into 3 groups based on the dermatochalasis severity (1- mild, 2- moderate, 3- severe). Additionally, a further division was conducted to assess the degree of enhancement observed after the treatment (1- slight improvement, 2- moderate improvement, 3- significant improvement). The classifications and assessments were performed by was graded by two trained dermatologists as blinded observers. A total of 21 eyes with a mean age of 54 years (range45-67 years) and 100% females were included in this study. The severity of dermatochalasis directly affects the clinical improvement (P=0.039) and the higher the severity, the more the improvement (R = -0.62). Noninvasive ablative microplasma may offer safe and effective therapy for upper eyelid dermatochalasis and can even be performed in patients at surgical risk. However, it may be suitable for grades 0 and 1 of DC. For more advanced grades a surgical solution achieves better results for the treatment of dermatochalasis of the upper eyelid.

确定在哪些情况下消融射频微等离子体治疗外侧皮肤松弛优于手术方法,并讨论每种方法的优点和局限性。21例患者接受了3次血浆运动干预。在基线和最后一次血浆运动后4周获得摄影和RCM图像。根据皮肤松弛的严重程度分为3组(1-轻度,2-中度,3-重度)。此外,进一步划分以评估治疗后观察到的增强程度(1-轻度改善,2-中度改善,3-显著改善)。分类和评估由两名训练有素的皮肤科医生作为盲法观察者进行评分。本研究共纳入21只眼,平均年龄54岁(45-67岁),100%为女性。皮癣严重程度直接影响临床改善(P=0.039),皮癣严重程度越高,改善程度越高(R = -0.62)。无创烧蚀微浆可以提供安全有效的治疗上睑皮松弛的方法,甚至可以在有手术风险的患者中进行。但是,它可能适用于DC的0级和1级。对于更高级的级别,手术解决方案达到更好的效果,为治疗皮肤松弛的上眼睑。
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引用次数: 0
Simulation of the temperature distribution of kidney stones induced by thulium fiber laser and Ho: YAG laser lithotripsy. 铥光纤激光与Ho: YAG激光碎石致肾结石的温度分布模拟。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-17 DOI: 10.1007/s10103-024-04255-0
Khwairakpam Shantakumar Singh, Thangjam Premabati

Simulation studies on temperature distribution in laser ablation help predict ablation rates, laser settings, and thermal damage. Despite the limited number of reported numerical studies on the temperature distribution of kidney fluid, there is no simulation study for kidney stone temperature distribution. We employ a numerical approach to study the kidney stone temperature distribution and predict ablation rates, which is an important parameter for clinical lithotripsy. The study looked at how the thulium fiber laser and the Ho:YAG laser differ in terms of temperature profile and ablation depth of kidney stones like calcium oxide monohydrate. The ablation depth increased from 152.7 µm to 489.7 µm when the TFL laser (operated at 10 Hz repetition rate and 1 ms pulse width) fluence increased from 764 J/cm2 to 1146 J/cm2. Correspondingly, the depth increased from 21 µm to 68 µm for the Ho: YAG laser operated at 3 Hz and 0.22 ms pulse width. We attribute this to an increase in temperature with laser energy. We further investigated the effect of pulse width on ablation depth by considering three different TFL pulse widths: 0.5 ms, 0.75 ms, and 1 ms. There was a decrease in ablation depths from 402.5 µm to 242.6 µm when the pulse width increased from 0.5 ms to 1 ms. Because of lower water absorption coefficients, the Ho:YAG laser (70 mJ/10 Hz) produced a smaller ablation depth and temperature profile than the thulium fiber laser (70 mJ/10 Hz). Experimental results from the literature validated the simulation. We found that the Ho:YAG laser worked better for ablation when it was set to 0.2 J/100 Hz for the Ho:YAG laser and 0.4 J/50 Hz for the TFL laser, which were clinical laser settings that we found in the literature. This indicates that, in addition to laser absorption by water, the laser parameters also significantly influence temperature distribution and ablation.

对激光烧蚀过程中的温度分布进行模拟研究有助于预测烧蚀率、激光设置和热损伤。尽管有关肾液温度分布的数值研究报告数量有限,但还没有针对肾结石温度分布的模拟研究。我们采用数值方法研究肾结石温度分布并预测消融率,这是临床碎石的一个重要参数。这项研究考察了铥光纤激光器和 Ho:YAG 激光器在肾结石(如一水氧化钙)的温度分布和烧蚀深度方面有何不同。当铥光纤激光器(以 10 Hz 重复频率和 1 ms 脉宽运行)的能量从 764 J/cm2 增加到 1146 J/cm2 时,烧蚀深度从 152.7 µm 增加到 489.7 µm。相应地,以 3 赫兹和 0.22 毫秒脉宽运行的 Ho: YAG 激光的深度从 21 微米增加到 68 微米。我们将此归因于温度随激光能量的增加而升高。我们进一步研究了脉冲宽度对烧蚀深度的影响,考虑了三种不同的 TFL 脉冲宽度:0.5 毫秒、0.75 毫秒和 1 毫秒。当脉冲宽度从 0.5 毫秒增加到 1 毫秒时,烧蚀深度从 402.5 微米降至 242.6 微米。由于水的吸收系数较低,Ho:YAG 激光器(70 mJ/10 Hz)产生的烧蚀深度和温度曲线小于铥光纤激光器(70 mJ/10 Hz)。文献中的实验结果验证了模拟结果。我们发现,如果将 Ho:YAG 激光器的功率设定为 0.2 J/100 Hz,将铥光纤激光器的功率设定为 0.4 J/50 Hz(这是我们在文献中找到的临床激光设定值),则消融效果更好。这表明,除了水对激光的吸收外,激光参数对温度分布和消融也有很大影响。
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引用次数: 0
Effects of high and low level lasers on soreness following dry needling in patients with chronic myofascial neck pain. A randomized-controlled trial. 高、低强度激光对慢性肌筋膜性颈部疼痛患者干针治疗后酸痛的影响。随机对照试验。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-16 DOI: 10.1007/s10103-024-04201-0
Maryam Motavalian, Siamak Bashardoust Tajali, Behrouz Attarbashi Moghadam, Seyedeh Zohreh Hosseini

This research was designed to study effects of high versus low-level laser therapy (HILT and LLLT) on post-dry needling soreness (PNS) at patients with chronic neck pain. We also studied effects of HLLT or LLLT application plus dry needling (DN) on pain, range of motion (ROM), and neck disability index (NDI) at the identified patients. This is a clinical trial in 48 women with chronic neck pain aged 18-35 who were divided into three groups: HLLT, LLLT, and placebo group. All the participants received one session of DN and laser therapy. The study assessed the soreness using Visual Analog Scale for needle pain (nVAS) and Pressure Pain Threshold (PPT) before, immediately after, 24 and 48 h after laser therapy. Pain, ROM, and NDI assessed before and also different time courses after DN plus laser therapy. PPT and nVAS improved in all groups over time. In the placebo group, nVAS increased significantly (p < 0.001) after treatment. VAS, NDI, and ROM improved 48 h after treatment in all groups. The VAS scores were substantially decreased (p < 0.001) immediately after treatment for LLLT group and also 24 h after treatment for both LLLT and HLLT groups. LLLT and HLLT might prevent immediately increasing the PNS. Adding one session of LLLT or HLLT to DN could effectively eliminate the neck pain at 24 h. All groups improved NDI and ROM the same. Registration number: IRCT20190411043241N1. Registered Sep 2, 2019.

这项研究旨在研究高、低强度激光疗法(HILT 和 LLLT)对慢性颈部疼痛患者干针治疗后酸痛(PNS)的影响。我们还研究了高强激光疗法或低强激光疗法加干针疗法(DN)对已确定患者的疼痛、活动范围(ROM)和颈部残疾指数(NDI)的影响。这是一项临床试验,研究对象是 48 名患有慢性颈部疼痛的 18-35 岁女性,她们被分为三组:HLLT 组、LLLT 组和安慰剂组。所有参与者都接受了一次 DN 和激光治疗。研究使用针刺痛视觉模拟量表(nVAS)和压痛阈值(PPT)评估了激光治疗前、治疗后、治疗后 24 小时和 48 小时的酸痛程度。在 DN 加激光治疗前和治疗后的不同时间段,还对疼痛、关节活动度和 NDI 进行了评估。随着时间的推移,各组的 PPT 和 nVAS 均有所改善。安慰剂组的 nVAS 显著增加(p
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引用次数: 0
Association between lipid-rich plaques and thrombus formation after excimer laser coronary angioplasty in in-stent restenosis and de novo lesions. 支架内再狭窄和新生病变的准分子激光冠状动脉血管成形术后富含脂质的斑块与血栓形成之间的关系。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-16 DOI: 10.1007/s10103-024-04265-y
Takayuki Nakano, Hiroki Ikenaga, Atsushi Takeda, Yuichi Morita, Tasuku Higashihara, Noriaki Watanabe, Yoshiharu Sada, Yukiko Nakano

Excimer laser coronary angioplasty (ELCA) in percutaneous coronary intervention (PCI) is safe and effective. However, thrombotic complications after ELCA occasionally occur. This study aimed to evaluate the impact of lipid-rich plaque in both in-stent restenosis (ISR) and de novo lesions on thrombus formation and transient no-reflow after ELCA. We conducted a single-center, retrospective, observational study including 27 lesions in 26 patients who underwent PCI with ELCA. Optical coherence tomography (OCT) was performed on all lesions before and immediately after ELCA. We measured the lipid angle per millimeter and lipid length of plaques with signal attenuation. We also recorded ELCA-induced thrombus formation and transient no-reflow. Thrombus formation and transient no-reflow were observed in nine (33%) and four lesions (15%), respectively. The frequency of ISR was significantly higher in the no-thrombus group than in the thrombus group. ISR lesions had a significantly lower lipid index (median [interquartile range] 108° [0°-756°] vs. 2541° [1205°-4336°]; p = 0.004) than de novo lesions. Among ISR lesions, those with ELCA-induced thrombus formation had a significantly higher lipid index (1370° [756°-4992°] vs. 29° [0°-285°]; p = 0.01) and significantly longer lipid length (8 mm [7-24 mm] vs. 0.5 mm [0-2.5 mm]; p = 0.01). The findings suggest that thrombus formation was more frequently observed in de novo lesions than in ISR lesions. OCT-detected lipid-rich plaques in ISR lesions were strongly associated with thrombus formation following ELCA.

经皮冠状动脉介入治疗(PCI)中的准分子激光冠状动脉血管成形术(ELCA)安全有效。然而,ELCA术后偶尔会出现血栓并发症。本研究旨在评估支架内再狭窄(ISR)和新生病变中的富脂斑块对 ELCA 术后血栓形成和一过性无血流的影响。我们进行了一项单中心、回顾性、观察性研究,研究对象包括 26 名接受 PCI 和 ELCA 的患者中的 27 个病变。在 ELCA 之前和之后立即对所有病灶进行了光学相干断层扫描 (OCT)。我们测量了有信号衰减的斑块的每毫米脂质角和脂质长度。我们还记录了 ELCA 诱导的血栓形成和一过性无回流。我们分别在9个病变(33%)和4个病变(15%)中观察到血栓形成和短暂的无回流。无血栓组发生 ISR 的频率明显高于血栓组。ISR病变的血脂指数(中位数[四分位间范围] 108° [0°-756°] vs. 2541° [1205°-4336°]; p = 0.004)明显低于新生病变。在 ISR 病变中,ELCA 诱导血栓形成的病变脂质指数明显更高(1370° [756°-4992°] vs. 29° [0°-285°];p = 0.01),脂质长度明显更长(8 mm [7-24 mm] vs. 0.5 mm [0-2.5 mm];p = 0.01)。研究结果表明,与 ISR 病变相比,血栓形成在新发病变中更为常见。在ISR病变中,OCT检测到的富脂斑块与ELCA后的血栓形成密切相关。
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引用次数: 0
Thulium fiber laser versus pulsed Thulium:YAG for laser lithotripsy during flexible ureteroscopy. 输尿管软镜激光碎石中铥光纤激光与脉冲铥YAG的对比。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-16 DOI: 10.1007/s10103-024-04267-w
Frédéric Panthier, Catalina Solano, Marie Chicaud, Stessy Kutchukian, Luigi Candela, Steeve Doizi, Mariela Corrales, Olivier Traxer

To compare the pulsed-Thulium: YAG(p-Tm: YAG) and Thulium Fiber(TFL) lasers in terms of efficiency and safety profiles during flexible ureteroscopy(fURS) and endocorporeal laser lithotripsy(ELL). A prospective single-center open-label comparative study included consecutive patients with ureteral and renal stones who underwent fURS using Thulio(p-Tm: YAG, Dornier©,Germany) or TFL Drive(TFL, Coloplast©,Danemark), with 270 μm and 150/200μm laser fibers(LF), respectively. fURS were performed by a single operator in each group. Demographics, stone size, stone density, laser-on time(LOT) and laser settings were recorded. Ablation speed(mm3/s), energy consumption(J/mm3) values for each procedure were also assessed. Stone-free rate(SFR, <3 mm fragments) and zero fragment rate(ZFR) on non-contrast computed tomography within 3 months postoperatively were also recorded. 36 and 39 patients were included in p-Tm: YAG and TFL group, respectively. Groups presented similar demographics but for high blood pressure(53vs23%,p = 0,005), anatomical abnormalities(8vs33%,p = 0,03), lower pole(8vs26%,p = 0,04) and pelvic stones(25vs13%,p = 0,04) for p-Tm: YAG and TFL, respectively. The median stone maximum diameter was higher in the p-Tm: YAG group(17.3vs13.8 mm, p = 0,001) but stone volume was similar among groups(1514vs1347mm3,p = 0,6). Laser settings were similar among groups(0,6-15 Hz,10-12 W). Shorter LOT(< 0,001) and lower UAS insertion(0,01) rates were reported for TFL compared to p-Tm: YAG. The median J/mm3 was similar(14vs17,p = 0,2) but p-Tm: YAG presented higher ablation speed(0,91vs0,73mm3/s, p = 0,04). SFR were similar among groups(75vs77%,p = 0,8) but ZFR was higher in TFL group(39vs64%,p = 0,008). No difference in complications was reported. Both p-Tm: YAG and TFL are safe and effective for ELL during fURS. SFR were similar between TFL and p-Tm: YAG but the latter presented lower ZFR, traducing its lower ability to dust. Using 200 μm laser fibers with p-Tm: YAG could nuance these findings.

比较脉冲铥:YAG(p-Tm: YAG)和铥纤维(TFL)激光器在柔性输尿管镜检查(fURS)和体内激光碎石术(ELL)中的效率和安全性。一项前瞻性单中心开放标签比较研究包括连续输尿管结石和肾结石患者,他们分别使用Thulio(p-Tm: YAG, Dornier©,德国)或TFL Drive(TFL, Coloplast©,丹麦),分别使用270 μm和150/200μm激光光纤(LF)进行fURS。每组由一名操作者进行fURS。记录了人口统计学、石材尺寸、石材密度、激光开机时间(LOT)和激光设置。还评估了每个过程的消融速度(mm3/s)、能耗(J/mm3)值。无石率(SFR, 3,p = 0,6)。各组激光设置相似(0,6-15 Hz,10-12 W),较短的LOT(3)相似(14vs17,p = 0,2),但p- tm: YAG具有更高的烧蚀速度(0,91vs0,73mm3/s, p = 0,04)。两组间SFR相似(75.vs77%,p = 0,8),但TFL组ZFR较高(39vs64%,p = 0,008)。并发症发生率无差异。p-Tm: YAG和TFL对fURS期间的ELL均安全有效。TFL与p-Tm: YAG的SFR相似,但p-Tm: YAG的ZFR较低,表明其抑尘能力较弱。使用含有p-Tm: YAG的200 μm激光光纤可以细微地改变这些发现。
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引用次数: 0
Effectiveness and safety of VISULAS® green selective laser trabeculoplasty: 12 months retrospective data. VISULAS® 绿色选择性激光小梁成形术的有效性和安全性:12 个月的回顾性数据。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-15 DOI: 10.1007/s10103-024-04252-3
Karin R Pillunat, Florian T A Kretz, Stefan Koinzer, Philipp Müller, Lutz E Pillunat, Karsten Klabe

To report the safety and effectiveness of selective laser trabeculoplasty (SLT) using the SLT mode of the VISULAS® green laser in patients with primary open-angle glaucoma (POAG). Twelve months results are presented. Retrospective extension in 4 German centers of an initially prospective interventional multicenter 3-month clinical investigation using the VISULAS® green SLT (Carl Zeiss Meditec AG, Jena, Germany) in patients with POAG who either needed treatment escalation or commenced treatment and had an IOP ≥ 17mmHg at baseline, with no previous glaucoma or other ocular surgery. Non-overlapping laser spots (100) were applied in a single session to 360° of the trabecular meshwork (TM). Glaucoma medications were not changed up to the 3-month visit. From 3 to 12 months, patients were managed according to routine standard of care. Outcome measures included IOP reduction, further glaucoma interventions, and adverse events from baseline to month 12. 25 eyes of 25 POAG patients (mean age 65.8 ± 8.5; modified intention to treat - mITT -group) were included in the extension study. Six eyes (24%) underwent additional glaucoma treatment or changed glaucoma therapy; the remaining 19 eyes (76%) had stable glaucoma therapy (SGT group) with no further glaucoma intervention or change in glaucoma medications (mean number of preoperative glaucoma medications: 2.3 ± 1.34). In the SGT group, mean baseline IOP (mmHg) was reduced from 20.0 ± 2.11 at baseline to 17.4 ± 3.25 and 16.2 ± 1.83 at 6 to 12 months, respectively (p < 0.0001): 52.6% had ≥ 20% IOP reduction at 12 months. Potential device- or procedure-related adverse events were mild to moderate and resolved without sequelae. SLT performed with the VISULAS® green laser reduced IOP in eyes with POAG up to 12 months with no relevant safety issues. The results are comparable to other reported SLT studies.

报告在原发性开角型青光眼(POAG)患者中使用 VISULAS® 绿激光的 SLT 模式进行选择性激光小梁成形术(SLT)的安全性和有效性。12 个月的结果已公布。在德国的 4 个中心进行了为期 3 个月的回顾性临床研究,该研究最初是使用 VISULAS® green SLT(卡尔蔡司医疗技术股份公司,德国耶拿,德国)对需要升级治疗或已开始治疗、基线眼压≥ 17mmHg、既往未患青光眼或接受过其他眼科手术的 POAG 患者进行的前瞻性干预性多中心临床研究。在一次治疗中对小梁网(TM)360°进行无重叠激光点照射(100 个)。青光眼药物在 3 个月的检查前没有更换。从 3 个月到 12 个月,患者按照常规标准进行治疗。结果测量包括眼压降低、进一步的青光眼干预以及从基线到第 12 个月的不良事件。25名POAG患者(平均年龄为65.8 ± 8.5岁;改良意向治疗组)的25只眼睛被纳入扩展研究。6只眼睛(24%)接受了额外的青光眼治疗或改变了青光眼治疗方法;其余19只眼睛(76%)接受了稳定的青光眼治疗(SGT组),没有进一步的青光眼干预或改变青光眼药物(术前青光眼药物的平均数量:2.3 ± 1.34)。在 SGT 组中,平均基线眼压(mmHg)从基线时的 20.0 ± 2.11 分别降至 6 至 12 个月时的 17.4 ± 3.25 和 16.2 ± 1.83(p ® 绿激光可降低 POAG 患者眼压长达 12 个月,且无相关安全问题。该结果与其他已报道的 SLT 研究结果相当。
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引用次数: 0
Efficacy of antimicrobial photodynamic therapy in endodontics of primary teeth: a scoping review. 抗菌光动力治疗在乳牙牙髓学中的疗效:范围综述。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-12 DOI: 10.1007/s10103-024-04250-5
Maria Luiza Costabeber Perin, Letícia Souza Mata da Silva, Maysa Lannes Duarte, Laura Guimarães Primo

The objective of this study was to identify, describe and synthesize the data published about the effectiveness of antimicrobial photodynamic therapy (aPDT) in the pulpectomy of primary teeth. A search was conducted in six electronic databases and the gray literature in June and July 2023, without restrictions on language or date of publication. The search strategy included indexed terms (MeSH terms) and your synonyms. Clinical trials, in vitro studies, case reports and retrospective studies that used photodynamic therapy in primary teeth pulpectomies were considered eligible. Among the 1,674 articles retrieved, 15 were included, published between 2014 and 2022, comprising six in vitro studies, five clinical trials, and four case reports. The sample consisted of children aged 2 to 8 years of both sexes, and included 1 to 62 teeth, mostly anterior. In two in vitro studies, the sample was taken from root canals. Most studies used a diode laser, methylene blue, and optical fiber. The pre-irradiation time ranged from 1 to 5 min. All protocols demonstrated microbial reduction before and after using aPDT, with no statistical difference among the groups. Furthermore, six studies demonstrated treatment success. Despite the divergence in methodology and protocols, aPDT is an effective method for reducing microorganisms, and is a promising adjunct treatment in primary teeth pulpectomies.

本研究的目的是鉴定、描述和综合有关抗菌光动力疗法(aPDT)在乳牙除牙术中的有效性的已发表的数据。在2023年6月和7月对6个电子数据库和灰色文献进行了检索,不受语言或出版日期的限制。搜索策略包括索引术语(MeSH术语)和同义词。临床试验,体外研究,病例报告和回顾性研究使用光动力治疗乳牙髓切除术被认为是合格的。在检索到的1674篇文章中,纳入了2014年至2022年间发表的15篇文章,包括6项体外研究、5项临床试验和4份病例报告。样本包括2至8岁的男女儿童,包括1至62颗牙齿,主要是前牙。在两项体外研究中,样本取自根管。大多数研究使用了二极管激光器、亚甲基蓝和光纤。预照射时间为1 ~ 5 min。所有方案在aPDT使用前后均显示微生物减少,组间无统计学差异。此外,6项研究表明治疗成功。尽管在方法和方案上存在分歧,但aPDT是一种有效的减少微生物的方法,是一种很有前途的辅助治疗方法。
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引用次数: 0
Immediate effects of traditional and laser acupuncture in chronic non-specific neck pain: a randomized controlled clinical trial. 传统和激光针灸治疗慢性非特异性颈部疼痛的即时效果:一项随机对照临床试验。
IF 2.1 4区 医学 Q3 ENGINEERING, BIOMEDICAL Pub Date : 2024-12-10 DOI: 10.1007/s10103-024-04235-4
Rafaela Peron, Cláudio Gregório Nuernberg Back, Érika Patrícia Rampazo, Milene Branco, Cleber Ferraresi, Richard Eloin Liebano

Neck pain is considered one of the most prevalent global public health problems. This study aimed to compare the immediate and subsequent effects of traditional acupuncture (TA) and laser acupuncture (LA) therapies in individuals with chronic non-specific neck pain. Eighty-four individuals were randomly allocated into 3 groups: TA (needle acupuncture treatment), LA (laser acupuncture treatment: 808 nm; 100 mW; 10 J per point), and S-LA (sham laser acupuncture). The participants were men and women aged between 18 and 60 years who had experienced chronic non-specific neck pain for a minimum period of 3 months. The Tianzhu, Fengchi, Jianjing, and Jianzhongshu acupuncture points were stimulated bilaterally. The primary outcomes were pain intensities at rest and during active neck movements, assessed using the Numerical Rating Scale. The secondary outcomes were Pressure Pain Threshold, Temporal Summation of pain, Conditioned Pain Modulation, and Global Perceived Effect scale. The assessments were performed immediately before and after a single treatment session. Additionally, determinations of pain intensity at rest and Global Perceived Effect were performed in a follow-up assessment one month after the interventions. The results showed that the TA and LA interventions were equally significantly superior in reducing immediate pain compared to placebo laser acupuncture (p = 0.001). Traditional acupuncture and laser acupuncture provided equally effective reductions of pain intensity in patients with chronic non-specific neck pain. Clinical Trial registration: RBR-7vbw5gd (Brazilian Registry of Clinical Trials - ReBEC).

颈部疼痛被认为是全球最普遍的公共卫生问题之一。本研究旨在比较传统针灸(TA)和激光针灸(LA)治疗慢性非特异性颈部疼痛的即时和后续效果。84例受试者随机分为3组:TA(针刺治疗)、LA(激光针灸治疗:808 nm;100兆瓦;每穴10j), S-LA(假激光针刺)。参与者是年龄在18到60岁之间的男性和女性,他们经历了至少3个月的慢性非特异性颈部疼痛。双侧刺激天柱穴、风池穴、建井穴、建中枢穴。主要结果是休息时和颈部活动时的疼痛强度,使用数值评定量表进行评估。次要结果为压力疼痛阈值、疼痛时间总和、条件性疼痛调节和整体感知效应量表。评估在单次治疗之前和之后立即进行。此外,在干预后一个月的随访评估中,确定休息时的疼痛强度和整体感知效应。结果显示,与安慰剂激光针刺相比,TA和LA干预在减轻即时疼痛方面同样具有显著优势(p = 0.001)。传统针灸和激光针灸对慢性非特异性颈部疼痛患者疼痛强度的减轻效果相同。临床试验注册:RBR-7vbw5gd(巴西临床试验注册中心- ReBEC)。
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Lasers in Medical Science
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