Pub Date : 2026-02-27DOI: 10.1007/s10103-026-04841-4
Zhongshuai Wang, Ting Li, Qingbiao Wa, Zhenfeng Liu, Bin Yang, Yan Yan
{"title":"Efficacy and safety of a novel monopolar radiofrequency device for skin tightening: a multicenter, randomized, 6-month, assessor blind, positive parallel-controlled, non-inferiority trial.","authors":"Zhongshuai Wang, Ting Li, Qingbiao Wa, Zhenfeng Liu, Bin Yang, Yan Yan","doi":"10.1007/s10103-026-04841-4","DOIUrl":"10.1007/s10103-026-04841-4","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12948897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-24DOI: 10.1007/s10103-025-04771-7
Aya E Mohamed, Wafaa R Mohamed, Mai A Elhemely, Tarek Mohamed
Breast cancer is one of the most prevalent and biologically diverse malignancies in women worldwide, encompassing subtypes such as ductal carcinoma in situ (DCIS), lobular carcinoma, and triple-negative breast cancer (TNBC). These variants present complex therapeutic challenges. Chemotherapy remains a core treatment modality, particularly in aggressive or advanced stages, yet its systemic toxicity and lack of specificity limit its efficacy. In recent years, laser-based therapies have emerged as adjunctive strategies to enhance therapeutic precision. This review explores breast cancer classification, progression, and treatment, with an emphasis on chemotherapy, and critically examines the emerging role of laser technologies, including low-level laser therapy (LLLT), Photochemotherapy, and Photodynamic Therapy (PDT), as adjunctive or alternative therapeutic options. We highlight the potential of laser to modulate the tumor microenvironment, improve drug delivery, regulate mitochondrial function, and enhance apoptosis. PDT showed promise in activating localized cytotoxic effects while sparing surrounding tissues. However, heterogeneity in laser parameters and treatment protocols remains a significant barrier to clinical translation. This review underscores the translational potential of laser-assisted chemotherapy, identifies current gaps, and suggests future research directions for optimized treatment strategies in breast oncology.
{"title":"Role of laser therapy in enhancing chemotherapy efficiency in breast cancer: low level laser therapy, photochemotherapy, and photodynamic therapy as promising treatments.","authors":"Aya E Mohamed, Wafaa R Mohamed, Mai A Elhemely, Tarek Mohamed","doi":"10.1007/s10103-025-04771-7","DOIUrl":"10.1007/s10103-025-04771-7","url":null,"abstract":"<p><p>Breast cancer is one of the most prevalent and biologically diverse malignancies in women worldwide, encompassing subtypes such as ductal carcinoma in situ (DCIS), lobular carcinoma, and triple-negative breast cancer (TNBC). These variants present complex therapeutic challenges. Chemotherapy remains a core treatment modality, particularly in aggressive or advanced stages, yet its systemic toxicity and lack of specificity limit its efficacy. In recent years, laser-based therapies have emerged as adjunctive strategies to enhance therapeutic precision. This review explores breast cancer classification, progression, and treatment, with an emphasis on chemotherapy, and critically examines the emerging role of laser technologies, including low-level laser therapy (LLLT), Photochemotherapy, and Photodynamic Therapy (PDT), as adjunctive or alternative therapeutic options. We highlight the potential of laser to modulate the tumor microenvironment, improve drug delivery, regulate mitochondrial function, and enhance apoptosis. PDT showed promise in activating localized cytotoxic effects while sparing surrounding tissues. However, heterogeneity in laser parameters and treatment protocols remains a significant barrier to clinical translation. This review underscores the translational potential of laser-assisted chemotherapy, identifies current gaps, and suggests future research directions for optimized treatment strategies in breast oncology.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10103-026-04839-y
Hyun Jeong Ju, Siwon Yun, Jongchul Lim, Hei Sung Kim
{"title":"Real-world ocular safety performance of dermatologic laser and intense pulsed light goggles: a clinical safety audit.","authors":"Hyun Jeong Ju, Siwon Yun, Jongchul Lim, Hei Sung Kim","doi":"10.1007/s10103-026-04839-y","DOIUrl":"10.1007/s10103-026-04839-y","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-23DOI: 10.1007/s10103-026-04836-1
Hao Xu, Wenbo Kuang, Dongxu Lin, Kang Li, Yang Luan, Kai Cui, Ting Yang, Zhong Chen
Purpose: Benign prostatic hyperplasia (BPH) is common in elderly men, causing lower urinary tract symptoms (LUTSs). The 1470 nm diode laser, with high vaporization efficiency and good hemostasis, is increasingly used for BPH. This study sought to comprehensively evaluate the efficacy and safety of 1470 nm diode laser enucleation of the prostate (DiLEP) forBPH in a prospective, multicenter study.
Methods: Conducted at two hospitals, BPH patients were randomized into two groups. Group A used a new 1470 nm diode laser device (Hefei Han's Kereida), and Group B utilized a conventional and widely validated 1470 nm laser system (Wuhan Qizhi). Prostate volume (PV), maximum flow rate (Qmax), post-void residual (PVR), International Prostate Symptom Score (IPSS), and Quality of Life (QoL) score were measured pre- and post-operatively. Perioperative indices and complications were also recorded.
Results: 143 patients (73 in Group A, 70 in Group B) completed follow-up. Baseline characteristics of two groups were comparable. Vital parameters remained within normal ranges following the surgical procedure. Both groups showed significant improvements in IPSS, QoL, Qmax, and PVR post-operatively, with no significant differences between groups. Complications occurred in 17 patients in Group A and 10 in Group B, all of which resolved spontaneously or were effectively managed with appropriate interventions.
Conclusion: 1470 nm DiLEP is an effective and safe BPH treatment, relieving symptoms with few complications. The new device from Hefei Han's Kereida performed reliably. This laser offers a valuable alternative to BPH surgeries.
{"title":"The efficacy and safety of 1470 nm diode laser in the treatment of benign prostatic hyperplasia: a prospective, multicenter study.","authors":"Hao Xu, Wenbo Kuang, Dongxu Lin, Kang Li, Yang Luan, Kai Cui, Ting Yang, Zhong Chen","doi":"10.1007/s10103-026-04836-1","DOIUrl":"10.1007/s10103-026-04836-1","url":null,"abstract":"<p><strong>Purpose: </strong>Benign prostatic hyperplasia (BPH) is common in elderly men, causing lower urinary tract symptoms (LUTSs). The 1470 nm diode laser, with high vaporization efficiency and good hemostasis, is increasingly used for BPH. This study sought to comprehensively evaluate the efficacy and safety of 1470 nm diode laser enucleation of the prostate (DiLEP) forBPH in a prospective, multicenter study.</p><p><strong>Methods: </strong>Conducted at two hospitals, BPH patients were randomized into two groups. Group A used a new 1470 nm diode laser device (Hefei Han's Kereida), and Group B utilized a conventional and widely validated 1470 nm laser system (Wuhan Qizhi). Prostate volume (PV), maximum flow rate (Qmax), post-void residual (PVR), International Prostate Symptom Score (IPSS), and Quality of Life (QoL) score were measured pre- and post-operatively. Perioperative indices and complications were also recorded.</p><p><strong>Results: </strong>143 patients (73 in Group A, 70 in Group B) completed follow-up. Baseline characteristics of two groups were comparable. Vital parameters remained within normal ranges following the surgical procedure. Both groups showed significant improvements in IPSS, QoL, Qmax, and PVR post-operatively, with no significant differences between groups. Complications occurred in 17 patients in Group A and 10 in Group B, all of which resolved spontaneously or were effectively managed with appropriate interventions.</p><p><strong>Conclusion: </strong>1470 nm DiLEP is an effective and safe BPH treatment, relieving symptoms with few complications. The new device from Hefei Han's Kereida performed reliably. This laser offers a valuable alternative to BPH surgeries.</p>","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12929312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-21DOI: 10.1007/s10103-026-04822-7
Tássio Malber Oliveira, Diego Mendes Xavier, Gracimério José Guarneire, Nerilson Marques Lima, Roberta Maria Abrão, Luiz Gustavo Vilela Filho, Brendha Sena Costa, Sandra Bertelli Ribeiro Castro, Caio César de Souza Alves, Alessandra de Paula Carli, Murilo Xavier Oliveira
{"title":"Synergistic anti-inflammatory effects of the aqueous extract from Desmodium heterophyllum and photobiomodulation in a carrageenan-induced paw edema model.","authors":"Tássio Malber Oliveira, Diego Mendes Xavier, Gracimério José Guarneire, Nerilson Marques Lima, Roberta Maria Abrão, Luiz Gustavo Vilela Filho, Brendha Sena Costa, Sandra Bertelli Ribeiro Castro, Caio César de Souza Alves, Alessandra de Paula Carli, Murilo Xavier Oliveira","doi":"10.1007/s10103-026-04822-7","DOIUrl":"10.1007/s10103-026-04822-7","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-20DOI: 10.1007/s10103-026-04825-4
Nima Rastegar-Pouyani, Alireza Nasirpour, Fatemeh Javani Jouni, Hossein Vazini, Ahmad Moshaii, Jaber Zafari
{"title":"Photobiomodulation mitigates the inhibitory effects of pirfenidone on cancer-associated fibroblasts and their pro-tumorigenic properties: a cause for concern.","authors":"Nima Rastegar-Pouyani, Alireza Nasirpour, Fatemeh Javani Jouni, Hossein Vazini, Ahmad Moshaii, Jaber Zafari","doi":"10.1007/s10103-026-04825-4","DOIUrl":"10.1007/s10103-026-04825-4","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A systematic review of therapeutic procedures for the treatment of morphea and systemic sclerosis.","authors":"Alireza Jafarzadeh, Amirhossein Leisi, Azadeh Goodarzi","doi":"10.1007/s10103-026-04799-3","DOIUrl":"10.1007/s10103-026-04799-3","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12923463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-18DOI: 10.1007/s10103-026-04815-6
Lance Lorenzo Babcock, Billy K Huh, Saba Javed
{"title":"High-intensity light therapy for post-interventional complications and pain after minimally invasive spinal procedures: a case series.","authors":"Lance Lorenzo Babcock, Billy K Huh, Saba Javed","doi":"10.1007/s10103-026-04815-6","DOIUrl":"10.1007/s10103-026-04815-6","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":"31"},"PeriodicalIF":2.4,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Light-emitting diode therapy for the prevention and treatment of radiodermatitis in women with breast cancer: systematic review.","authors":"Fahimeh Nouri, Masoumeh Sadeghi, Samira Ebrahimzadeh Zagami","doi":"10.1007/s10103-026-04803-w","DOIUrl":"10.1007/s10103-026-04803-w","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":"32"},"PeriodicalIF":2.4,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12916891/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146220190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-02-16DOI: 10.1007/s10103-026-04812-9
Hernán Andrés de la Barra Ortiz, Nivaldo Antonio Parizotto, Richard Eloin Liebano
{"title":"Comparison of the effectiveness of high-intensity laser therapy versus low-level laser therapy in musculoskeletal disorders: a systematic review and network meta-analysis.","authors":"Hernán Andrés de la Barra Ortiz, Nivaldo Antonio Parizotto, Richard Eloin Liebano","doi":"10.1007/s10103-026-04812-9","DOIUrl":"10.1007/s10103-026-04812-9","url":null,"abstract":"","PeriodicalId":17978,"journal":{"name":"Lasers in Medical Science","volume":"41 1","pages":"30"},"PeriodicalIF":2.4,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146202083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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