Life Sciences in Space Research最新文献

{"title":"Comparative analysis of brassica rapa var. cymosa grown in hydroponic condition, lunar maria, and lunar highland regolith simulants: biochemical profiling and effects on drosophila melanogaster as an in vivo model","authors":"Fatemeh Mansouri ,&nbsp;Ana Novo Barros ,&nbsp;Laura Bordoni ,&nbsp;Donatella Fedeli ,&nbsp;Giorgia Pontetti ,&nbsp;Eugenia Roncolato ,&nbsp;Cinzia Mannozzi ,&nbsp;Francesca Pompei ,&nbsp;Sauro Vittori ,&nbsp;Elena Pettinelli ,&nbsp;Natasha Gomes De Miranda ,&nbsp;Isabel Gaivão ,&nbsp;Rosita Gabbianelli","doi":"10.1016/j.lssr.2025.11.008","DOIUrl":"10.1016/j.lssr.2025.11.008","url":null,"abstract":"<div><h3>Background</h3><div>Sustainable crop cultivation in extraterrestrial environments is essential for future space missions. Lunar regolith simulants may influence plant biochemical properties and safety, yet their effects on plant quality and downstream biological responses remain underexplored.</div></div><div><h3>Methods</h3><div>Brassica rapa var. cymosa was cultivated under hydroponic conditions and in two lunar regolith simulants (lunar maria and lunar highland). Polyphenol profiles, antioxidant capacity, chlorophyll, and carotenoid contents were analyzed. <em>Drosophila melanogaster</em> (Oregon-K) flies were fed media supplemented with five concentrations of each plant sample and a control. DNA damage in larval brain neuroblasts was assessed via comet assay. Adult fly behavior, longevity, and prolificacy were evaluated.</div></div><div><h3>Results</h3><div>Lunar maria sample showed significantly higher levels of neochlorogenic acid, ferulic acid, and p-coumaric acid, along with increased total phenolic content and chlorophyll a compared to hydroponic and lunar highland samples. Antioxidant capacity, assessed using ferric reducing antioxidant power (FRAP), 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays, was higher in lunar-grown plants than in hydroponic ones, whereas oxygen radical absorbance capacity (ORAC) showed no significant difference. DNA damage was increased across all larval groups but was lowest in the lunar maria group at moderate concentrations. Despite early genotoxic stress, adult flies developed normally, with comparable longevity and reproductive output. Notably, flies fed lunar maria samples exhibited enhanced climbing ability.</div></div><div><h3>Conclusion</h3><div>Cultivation in lunar regolith simulants alters plant biochemistry and induces early DNA damage in drosophila larvae without impairing adult health or behavior. The lunar maria simulant, in particular, promotes beneficial phytochemical traits and organismal resilience. These findings underscore both the challenges and potential of lunar agriculture, emphasizing the critical role of substrate choice in developing sustainable space farming systems.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 174-187"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research on a microgravity-adapted controlled-release fertilizer for space plant cultivation and its application experiments in the space station","authors":"Yunze Shen ,&nbsp;Haipeng Jing ,&nbsp;Yongkang Tang ,&nbsp;Weidang Ai ,&nbsp;Shuangsheng Guo ,&nbsp;Liangchang Zhang ,&nbsp;Ruixin Mao ,&nbsp;Zhiqiang Wu","doi":"10.1016/j.lssr.2025.09.004","DOIUrl":"10.1016/j.lssr.2025.09.004","url":null,"abstract":"<div><div>This study developed a microgravity-adapted controlled-release fertilizer (CRF) for space plant cultivation and conducted application experiments aboard the Tiangong Space Station. First, through regular sampling and analysis, the nutrient uptake curve of lettuce under simulated microgravity was determined. Based on this curve, a CRF suitable for space cultivation was designed through adjustments in coating thickness and the incorporation of fertilizer particles with distinct release profiles. Subsequently, optimal application strategies were determined through simulated space environment experiments. The CRF was then applied in the Tiangong Space Station using the “Space Vegetable Garden” (SVG) facility to cultivate three lettuce varieties. Throughout the growth period, the substrate electrical conductivity was maintained within an optimal range of 150–300 mS/m. Under microgravity, the substrate nutrient distribution showed an upper-rich and lower-poor pattern, contrary to terrestrial conditions. The lettuce grown in space developed well, yielding nearly equivalent to ground-grown plants, with no observed symptoms of nutrient deficiency or salt stress. The expression levels of genes associated with nutrient deficiency (<em>LsNLP, LsPHT1, LsWRKY</em>) and salt tolerance (<em>LsSOS1</em>) were comparable to those in ground controls, indicating sufficient nutrient provision. Additionally, microgravity induced early bolting and flowering in lettuce. Analysis of returned samples revealed altered hormone distribution and up-regulated expression of flowering-related genes (<em>LsFT, LsSOC1, LsLFY</em>). This study enhances nutrient use efficiency and vegetable production capacity in space, advances understanding of microgravity effects on plant physiology, and provides technical support for developing controlled ecological life support systems (CELSS) for long-duration deep-space missions. Furthermore, it advances interdisciplinary research at the intersection of space science, agricultural engineering, and plant biology.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 232-241"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of social isolation alone and combined with15cGy GCRsim Space radiation on fear conditioned behavioral, stress and sleep responses","authors":"Larry D. Sanford ,&nbsp;Austin M. Adkins ,&nbsp;Alea F. Boden ,&nbsp;Zachary N.M. Luyo ,&nbsp;Namrata Singh ,&nbsp;Richard A. Britten ,&nbsp;Laurie L. Wellman","doi":"10.1016/j.lssr.2025.10.001","DOIUrl":"10.1016/j.lssr.2025.10.001","url":null,"abstract":"<div><div>Astronauts on deep space missions will be exposed to physical and psychological stressors, including space radiation (SR) and periods of social isolation (SI). The effects of these inflight stressors can be complex because they have different time courses and durations, and could have additive or synergistic effects that may vary depending on individual differences in stress resilience (Res) and vulnerability (Vul). Determining the effects of inflight stressors and how they impact astronaut health and performance will be crucial for understanding, and mitigating, factors that could jeopardize mission success. In this study, we assessed how SI and SI + SR (dual flight stressors (DFS)) impacted the ability of rats to cope with additional unexpected stress using a fear conditioning paradigm. We examined both stress-induced and fear memory-induced freezing behavior, body temperature as an index of stress-induced hyperthermia (SIH), and changes in post-stress sleep amounts and architecture. We also determined whether responses differed in Res and Vul phenotypes based on our established model in which stress produces different effects on sleep. SI alone did not significantly alter freezing and produced only minimal differences in SIH. The effect of SI on sleep varied with phenotype but was generally associated with reduced NREM. By comparison, DFS significantly increased freezing and SIH, and also significantly altered post-stress sleep with some differences between phenotypes. These data demonstrate that SI alone and in combination with SR can significantly alter responses to additional unexpected challenges that astronauts may face. They also indicate that DFS may dramatically impact responses and outcomes to unexpected stress that occurs during deep space missions.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 132-142"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposing Drosophila to wheat-derived microbes enhances its immunity and survival under simulated microgravity","authors":"Letian Chen ,&nbsp;Shijing Wang ,&nbsp;Chuanmeng Cai ,&nbsp;Jingjing Cui ,&nbsp;Hong Liu ,&nbsp;Yuming Fu","doi":"10.1016/j.lssr.2025.09.003","DOIUrl":"10.1016/j.lssr.2025.09.003","url":null,"abstract":"<div><div>During prolonged space habitation, microgravity compromises astronaut immunity, increasing the risk of infectious diseases. Plant-derived microbes offer a promising strategy for enhancing immunity, yet their feasibility and mechanisms remain unclear. We co-cultivated wheat and <em>Drosophila</em> under simulated microgravity (SMG), examining changes in <em>Drosophila</em> immunity through a multi-omics approach. Our findings demonstrate that exposure to wheat-derived microbes significantly boosts <em>Drosophila</em>'s survival and immunity, confirming their transfer and colonization in the host. Notably, immune-related microbes like <em>Massilia</em> and <em>Longimicrobium</em> were enriched. This exposure markedly upregulated <em>Drosophila</em> key immune genes in Toll signaling and glutathione metabolism, enhancing immune substance secretion. Multi-omics cojoint analysis further indicated that these microbes ameliorated immune dysfunction in <em>Drosophila</em>, providing an innovative strategy to bolster astronaut immunity during space missions and a theoretical foundation for life support systems in extended space exploration.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 88-98"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential regulation of mitochondrial quality control in skeletal muscle by HZE radiation exposure and partial weightbearing in mice","authors":"Carla MC Nascimento ,&nbsp;James D. Fluckey ,&nbsp;Florence Lima ,&nbsp;Brandon R. Macias ,&nbsp;Yasaman Shirazi-Fard ,&nbsp;Elizabeth S. Greene ,&nbsp;Leslie A. Braby ,&nbsp;Susan A. Bloomfield ,&nbsp;Michael P Wiggs","doi":"10.1016/j.lssr.2025.10.008","DOIUrl":"10.1016/j.lssr.2025.10.008","url":null,"abstract":"<div><div>Spaceflight places astronauts under both reduced mechanical loading and ionizing radiation, each of which can compromise skeletal muscle health. We investigated whether 21 days of simulated lunar gravity (one sixth G) with or without a single 0.5 Gy dose of ²⁸Si heavy ion radiation alters transcriptional regulators of mitochondrial quality control in mouse gastrocnemius muscle. Female BALB/cByJ mice were assigned to four groups: Sham + 1 G (SHAM+CC), Rad + 1 G (RAD+CC), Sham + <em>G</em>/6 (SHAM+<em>G</em>/6), Rad + <em>G</em>/6 (RAD+<em>G</em>/6) and relative mRNA levels of key regulators of mitochondrial biogenesis, mitophagy, dynamics and electron transport chain content were measured by quantitative RT-PCR. Radiation significantly suppressed PGC-1α (<em>p</em> = 0.035) and TFAM (<em>p</em> = 0.051) transcripts and reduced LC3b (<em>p</em> = 0.033) and Park2 (<em>p</em> = 0.007) expression; no effects of simulated lunar gravity or interaction effects were detected. Composite scores confirmed suppression of biogenesis (<em>p</em> = 0.029) and a trend toward reduced mitophagy (<em>p</em> = 0.057). Transcripts encoding oxidative phosphorylation subunits and fusion and fission factors remained unchanged, suggesting preserved mitochondrial content and network homeostasis at day 21. These findings indicate that a single space relevant heavy ion exposure selectively disrupts early transcriptional steps of mitochondrial turnover without immediately altering organelle abundance of transcripts for electron transport chain or dynamics; in contrast simulated lunar gravity alone did not elicit changes in these pathways.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 156-165"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gravity-induced inhibition of the H-reflex and the modulatory potential of the bone myoregulation reflex","authors":"Selim Sezikli ,&nbsp;Nilgün Yıldız ,&nbsp;Eser Kalaoglu ,&nbsp;Ismet Alkım Özkan ,&nbsp;Muhammed Yurtseven ,&nbsp;Tugba Aydin ,&nbsp;Hatice Kumru ,&nbsp;Ilhan Karacan ,&nbsp;Kemal Sıtkı Türker","doi":"10.1016/j.lssr.2025.11.010","DOIUrl":"10.1016/j.lssr.2025.11.010","url":null,"abstract":"<div><div>The osteocytic network is capable of responding to mechanical stimuli such as gravitational loading or whole-body vibration (WBV), which may potentially initiate the bone myoregulation reflex (BMR). This study explored whether increasing gravitational load is associated with progressive suppression of the soleus H-reflex, whether cyclic (vibratory) versus continuous loading might differentially influence this suppression, and whether the BMR could contribute to this modulation. Twelve healthy young adults participated in two experiments. In Experiment I, H-reflex amplitude was assessed under both static and dynamic loading conditions: in the static condition, 0, 50, and 100% body weight (BW) were applied to the right heel; in the dynamic condition, 50% BW was combined with WBV (30 Hz, 2 mm peak-to-peak displacement, 60 s duration). In Experiment II, the latencies of the BMR and the tendon reflex (T-reflex) were recorded. Mean H/Mmax ratios were 0.30 ± 0.15 (0% BW), 0.24 ± 0.14 (50% BW), and 0.15 ± 0.09 (100% BW), showing a significant progressive decrease with increasing load (<em>p</em> &lt; 0.001). During WBV, despite a similar average load, the H/Mmax ratio markedly declined to 0.01 ± 0.02, indicating significantly greater suppression than under static loading of equivalent magnitude. In Experiment II, the latency of the BMR was approximately 10 ms longer than that of the soleus T-reflex. These findings indicate that suppression of the H-reflex tends to increase progressively with greater gravitational loading under static conditions but appears to become substantially more pronounced during dynamic loading (vibration). BMR-mediated afferent input may partly contribute to the greater inhibition observed, especially under dynamic conditions. From a translational perspective, understanding these mechanisms may inform countermeasure strategies for astronauts, where targeted exercise and vibration protocols could help mitigate neuromuscular and skeletal challenges associated with microgravity.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 196-203"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gypsophytes and the use of Martian Gypsum: A review of their potential for agriculture on Mars","authors":"Miguel de Luis ,&nbsp;Jordi López-Pujol ,&nbsp;Juan Mota ,&nbsp;M. Encarna Merlo ,&nbsp;Julio Álvarez-Jiménez ,&nbsp;Jose Ignacio Aparicio ,&nbsp;Carmen Bartolomé ,&nbsp;Jens Ormö ,&nbsp;Laura M. Parro","doi":"10.1016/j.lssr.2025.09.009","DOIUrl":"10.1016/j.lssr.2025.09.009","url":null,"abstract":"<div><div>Gypsophytes are plants that thrive on gypsum soils on Earth. They possess some adaptive traits that could constitute pre-adaptations to the conditions for potential cultivation in a controlled habitat on Mars. Martian agriculture should utilize substrates obtained directly from the planet itself. However, the detection of perchlorates in the soil of Mars raises doubts about this possibility. These molecules are distributed globally and in concentrations toxic to both humans and plants. The polar winds may preserve some Martian gypsum outcrops from the effects of perchlorates. If so, using this Martian gypsum as a growing substrate for gypsophytes may be a viable option. In the medium term, implementing gypsophyte adaptations on staple crops would also be possible using CRISPR-Cas9 and/or other gene-editing technologies. According to the literature reviewed, <em>Gypsophila struthium</em> subsp. <em>struthium</em> shows a high degree of colonization capacity and high resistance to drought. This taxon serves as an ecological facilitator for other species, and its germination appears to be favored by the presence of gypsum. Several experimental results suggest it would be worthwhile to test the cultivation of this and other plants on reliable simulants or Martian gypsum through sample return missions or on a mission that would perform the cultivation on Mars itself.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 17-25"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced accuracy in radiation dose estimation for astronauts using mesh-type reference computational phantoms","authors":"Vivek Kaushik ,&nbsp;Sabyasachi Paul ,&nbsp;Sunder Sahayanathan ,&nbsp;S Anand","doi":"10.1016/j.lssr.2025.11.012","DOIUrl":"10.1016/j.lssr.2025.11.012","url":null,"abstract":"<div><div>With the increasing ambition of deep space missions, the accurate estimation of radiation doses to astronauts has become a critical concern. Traditional radiation dose estimation methods may often overestimate the biological impact due to their limitations in accurately modelling thin-layered organs. This study employs advanced Mesh-type Reference Computational Phantoms (MRCPs) along with the Geant4 simulation toolkit to calculate dose conversion coefficients and quality factors for various radiations, including protons, alpha particles, carbon, magnesium, and iron ions using both ICRP and NASA radiation quality factor models. The results demonstrate improvements in dose estimations, particularly for organs with thin structures, such as the skin. For example, at energies below 10 MeV/u, the absorbed dose to the skin calculated using the MRCP phantom was up to 30 % lower than that obtained from the Voxel-type Reference Computational Phantoms (VRCPs), due to the MRCP's ability to distinguish between sensitive and insensitive skin layers. Similarly, the quality factors for heavy ions (e.g., iron and magnesium) calculated using the MRCP were 10–20 % lower at intermediate energies (10–100 MeV/u) compared to VRCP-based values, reflecting more accurate LET-dependent biological effectiveness calculations. Additionally, the body-mean quality factor for protons at low energies (&lt;100 MeV/u) showed a 15 % reduction when using MRCPs, correcting previous estimations from VRCP-based methods. The improved accuracy in dose and quality factor calculations enables better-informed decisions regarding mission planning, shielding requirements, and radiation protection strategies.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 250-259"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dose-specific lncRNA–mRNA networks modulate DNA damage and immune responses in CD4⁺ T cells under simulated space UVC irradiation","authors":"Xiaolin Ding ,&nbsp;Yue Pang ,&nbsp;Boxiang Zhang ,&nbsp;Lei Zhao ,&nbsp;Xiaoyan Niu ,&nbsp;Dan Xu","doi":"10.1016/j.lssr.2025.09.010","DOIUrl":"10.1016/j.lssr.2025.09.010","url":null,"abstract":"<div><div>Ultraviolet-C (UVC) irradiation is a prevalent component of the extraterrestrial radiation spectrum. To explore how long non-coding RNAs (lncRNAs) orchestrate cellular responses under simulated space UVC radiation, we exposed human CD4⁺ T cells to varying doses of UVC (100–800 J/m²). High-dose (400 and 800 J /m²) exposure significantly reduced cell viability and elevated reactive oxygen species (ROS) levels, whereas low-dose (100 and 200 J/m²) exposure triggered only modest ROS increases without compromising cell survival. At 24 h post-irradiation, microarray profiling revealed that the low-dose group was found to have a total of 155 mRNAs and 62 lncRNAs with altered expression, which were enriched in DNA damage response and p53 signaling pathways. In contrast, the high-dose group exhibited 913 mRNAs and 913 lncRNAs linked to immune and metabolic pathways. Co-expression analyses identified distinct lncRNA–mRNA networks in response to different UVC doses. Specifically, three lncRNAs were found to be positively or negatively correlated with eight DNA-repair transcripts in the low-dose group, while four lncRNAs showed positive correlations with six immune-related mRNAs in the high-dose group. These expression changes were confirmed by RT-qPCR. Notably, survival analyses in melanoma datasets implicated CDKN1A, MDM2 and lncRNA CMAHP as potential prognostic targets. Collectively, our findings demonstrate that space-level UVC doses are interpreted by dose-specific lncRNA–mRNA networks that direct either DNA damage response or immune-defense programs in CD4⁺ T cells.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 123-131"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital twin modelling in microgravity: A framework for predictive and personalised space medicine","authors":"Ruqaiyyah Siddiqui ,&nbsp;Rizwan Qaisar ,&nbsp;Adel Elmoselhi ,&nbsp;Naveed Ahmed Khan","doi":"10.1016/j.lssr.2025.11.004","DOIUrl":"10.1016/j.lssr.2025.11.004","url":null,"abstract":"<div><div>Human spaceflight exposes the body to a complex array of physiological stressors that collectively alter cardiovascular, musculoskeletal, immune, and nervous systems. Continuous biomedical monitoring produces vast, but fragmented datasets including physiological data, omics profiles, imaging, and behavioural metrics. However, these data are often analysed retrospectively rather than used dynamically to guide countermeasures in real time. Digital twin technology, which creates adaptive computational replicas of physical systems that evolve with incoming data, provides a novel framework for personalised astronaut health management. This article outlines how individualised digital twins could integrate multi-omics, physiological, and environmental data to predict deconditioning, optimise countermeasure protocols, and guide in-flight medical decisions. A phased roadmap for implementation is proposed, from Earth-based analogue validation to mission-integrated predictive modelling. Digital twins could ultimately enable precision space medicine, transforming astronaut monitoring from observation to anticipation.</div></div>","PeriodicalId":18029,"journal":{"name":"Life Sciences in Space Research","volume":"48 ","pages":"Pages 37-39"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145996135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}