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Rapid simultaneous estimation of relaxation rates using multi-echo, multi-contrast MRI 利用多回波、多对比 MRI 快速同步估算弛豫率。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-07-04 DOI: 10.1016/j.mri.2024.07.007
Elizabeth G. Keeling , Nicholas J. Sisco , Molly M. McElvogue , Aimee Borazanci , Richard D. Dortch , Ashley M. Stokes

Purpose

Multi-echo, multi-contrast methods are increasingly used in dynamic imaging studies to simultaneously quantify R2 and R2. To overcome the computational challenges associated with nonlinear least squares (NLSQ) fitting, we propose a generalized linear least squares (LLSQ) solution to rapidly fit R2 and R2.

Methods

Spin- and gradient-echo (SAGE) data were simulated across T2 and T2 values at high (200) and low (20) SNR. Full (four-parameter) and reduced (three-parameter) parameter fits were implemented and compared with both LLSQ and NLSQ fitting. Fit data were compared to ground truth using concordance correlation coefficient (CCC) and coefficient of variation (CV). In vivo SAGE perfusion data were acquired in 20 subjects with relapsing-remitting multiple sclerosis. LLSQ R2 and R2, as well as cerebral blood volume (CBV), were compared with the standard NLSQ approach.

Results

Across all fitting methods, T2 was well-fit at high (CCC = 1, CV = 0) and low (CCC ≥ 0.87, CV ≤ 0.08) SNR. Except for short T2 values (5–15 ms), T2 was well-fit at high (CCC = 1, CV = 0) and low (CCC ≥ 0.99, CV ≤ 0.03) SNR. In vivo, LLSQ R2 and R2 estimates were similar to NLSQ, and there were no differences in R2 across fitting methods at high SNR. However, there were some differences at low SNR and for R2 at high and low SNR. In vivo NLSQ and LLSQ three parameter fits performed similarly, as did NLSQ and LLSQ four-parameter fits. LLSQ CBV nearly matched the standard NLSQ method for R2- (0.97 ratio) and R2-CBV (0.98 ratio). Voxel-wise whole-brain fitting was faster for LLSQ (3–4 min) than NLSQ (16–18 h).

Conclusions

LLSQ reliably fit for R2 and R2 in simulated and in vivo data. Use of LLSQ methods reduced the computational demand, enabling rapid estimation of R2 and R2.

目的:动态成像研究中越来越多地使用多回波、多对比度方法来同时量化 R2* 和 R2。为了克服非线性最小二乘法(NLSQ)拟合带来的计算挑战,我们提出了一种广义线性最小二乘法(LLSQ)解决方案来快速拟合 R2* 和 R2:方法:在高(200)和低(20)信噪比条件下模拟自旋和梯度回波(SAGE)数据的 T2⁎和 T2 值。采用全参数(四参数)和缩减参数(三参数)拟合,并与 LLSQ 和 NLSQ 拟合进行比较。使用一致性相关系数(CCC)和变异系数(CV)将拟合数据与地面实况进行比较。20 名复发性多发性硬化症患者获得了体内 SAGE 灌注数据。将 LLSQ R2* 和 R2 以及脑血量(CBV)与标准 NLSQ 方法进行了比较:在所有拟合方法中,T2⁎ 在高信噪比(CCC = 1,CV = 0)和低信噪比(CCC ≥ 0.87,CV ≤ 0.08)时拟合良好。除了短 T2⁎值(5-15 毫秒)外,T2 在高信噪比(CCC = 1,CV = 0)和低信噪比(CCC ≥ 0.99,CV ≤ 0.03)时拟合良好。在体内,LLSQ R2⁎和 R2 估计值与 NLSQ 相似,在高信噪比时,不同拟合方法的 R2⁎没有差异。然而,在低信噪比时,以及在高信噪比和低信噪比时,R2存在一些差异。体内 NLSQ 和 LLSQ 三参数拟合表现相似,NLSQ 和 LLSQ 四参数拟合表现也相似。LLSQ CBV 的 R2*- 比率(0.97)和 R2-CBV 比率(0.98)几乎与标准 NLSQ 方法相当。LLSQ 全脑体素拟合(3-4 分钟)比 NLSQ(16-18 小时)更快:结论:LLSQ能可靠地拟合模拟和体内数据中的R2*和R2。使用 LLSQ 方法降低了计算需求,从而能够快速估算 R2⁎和 R2。
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引用次数: 0
Beyond conventional imaging: Advancements in MRI for glioma malignancy prediction and molecular profiling 超越传统成像:磁共振成像在胶质瘤恶性程度预测和分子谱分析方面的进展。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-22 DOI: 10.1016/j.mri.2024.06.004
Paulina Śledzińska-Bebyn , Jacek Furtak , Marek Bebyn , Zbigniew Serafin

This review examines the advancements in magnetic resonance imaging (MRI) techniques and their pivotal role in diagnosing and managing gliomas, the most prevalent primary brain tumors. The paper underscores the importance of integrating modern MRI modalities, such as diffusion-weighted imaging and perfusion MRI, which are essential for assessing glioma malignancy and predicting tumor behavior. Special attention is given to the 2021 WHO Classification of Tumors of the Central Nervous System, emphasizing the integration of molecular diagnostics in glioma classification, significantly impacting treatment decisions. The review also explores radiogenomics, which correlates imaging features with molecular markers to tailor personalized treatment strategies. Despite technological progress, MRI protocol standardization and result interpretation challenges persist, affecting diagnostic consistency across different settings. Furthermore, the review addresses MRI's capacity to distinguish between tumor recurrence and pseudoprogression, which is vital for patient management. The necessity for greater standardization and collaborative research to harness MRI's full potential in glioma diagnosis and personalized therapy is highlighted, advocating for an enhanced understanding of glioma biology and more effective treatment approaches.

这篇综述探讨了磁共振成像(MRI)技术的发展及其在诊断和管理胶质瘤(最常见的原发性脑肿瘤)中的关键作用。论文强调了整合现代磁共振成像模式的重要性,如弥散加权成像和灌注磁共振成像,它们对于评估胶质瘤恶性程度和预测肿瘤行为至关重要。书中特别关注了 2021 年世界卫生组织《中枢神经系统肿瘤分类》,强调了将分子诊断纳入胶质瘤分类的重要性,这将对治疗决策产生重大影响。综述还探讨了放射基因组学,它将成像特征与分子标记物相关联,以定制个性化治疗策略。尽管技术不断进步,但核磁共振成像方案标准化和结果判读方面的挑战依然存在,影响了不同环境下诊断的一致性。此外,综述还讨论了磁共振成像区分肿瘤复发和假性进展的能力,这对患者管理至关重要。综述强调了加强标准化和合作研究的必要性,以充分发挥磁共振成像在胶质瘤诊断和个性化治疗中的潜力,倡导加强对胶质瘤生物学和更有效治疗方法的了解。
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引用次数: 0
3D vector MR elastography applications in small organs 三维矢量磁共振弹性成像在小器官中的应用。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-21 DOI: 10.1016/j.mri.2024.06.005
Vitaliy Atamaniuk , Łukasz Hańczyk , Jun Chen , Andrii Pozaruk , Marzanna Obrzut , Krzysztof Gutkowski , Wojciech Domka , Marian Cholewa , Richard L. Ehman , Bogdan Obrzut

Background

Magnetic resonance elastography (MRE) is a rapidly developing medical imaging technique that allows for quantitative assessment of the biomechanical properties of the tissue. MRE is now regarded as the most accurate noninvasive test for detecting and staging liver fibrosis. A two-dimensional (2D MRE) acquisition version is currently deployed at >2000 locations worldwide. 2D MRE allows for the evaluation of the magnitude of the complex shear modulus, also referred to as stiffness. The development of 3D vector MRE has enabled researchers to assess the biomechanical properties of small organs where wave propagation cannot be adequately analyzed with the 2D MRE imaging approach used in the liver. In 3D vector MRE, the shear waves are imaged and processed throughout a 3D volume and processed with an algorithm that accounts for wave propagation in any direction. Additionally, the motion is also imaged in x, y, and z directions at each voxel, allowing for more advanced processing to be applied.

Purpose

This review describes the technical principles of 3D vector MRE, surveys its clinical applications in small organs, and discusses potential clinical significance of 3D vector MRE.

Conclusion

3D vector MRE is a promising tool for characterizing the biomechanical properties of small organs such as the uterus, pancreas, thyroid, prostate, and salivary glands. However, its potential has not yet been fully explored.

背景:磁共振弹性成像(MRE)是一种快速发展的医学成像技术,可对组织的生物力学特性进行定量评估。目前,磁共振弹性成像被认为是检测和分期肝纤维化最准确的无创检测方法。二维(2D MRE)采集版本目前已在全球超过 2000 个地点部署。二维 MRE 可以评估复合剪切模量(也称为硬度)的大小。三维矢量 MRE 的开发使研究人员能够评估小器官的生物力学特性,因为在肝脏中使用的二维 MRE 成像方法无法充分分析波的传播。在三维矢量 MRE 中,剪切波在整个三维容积中成像和处理,并采用一种算法进行处理,该算法可考虑波在任何方向的传播。目的:这篇综述描述了三维矢量 MRE 的技术原理,调查了其在小器官中的临床应用,并讨论了三维矢量 MRE 的潜在临床意义。结论:三维矢量 MRE 是表征子宫、胰腺、甲状腺、前列腺和唾液腺等小器官生物力学特性的一种很有前途的工具。然而,其潜力尚未得到充分挖掘。
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引用次数: 0
Ischemia-reperfusion injury in a salvaged penumbra: Longitudinal high-tesla perfusion magnetic resonance imaging in a rat model 挽救性半影的缺血再灌注损伤:大鼠模型的纵向高特斯拉灌注磁共振成像。
IF 2.1 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-21 DOI: 10.1016/j.mri.2024.06.003
Duen-Pang Kuo , Yung-Chieh Chen , Sho-Jen Cheng , Kevin Li-Chun Hsieh , Chen-Yin Ou , Yi-Tien Li , Cheng-Yu Chen

Introduction

Although ischemia-reperfusion (I/R) injury varies between cortical and subcortical regions, its effects on specific regions remain unclear. In this study, we used various magnetic resonance imaging (MRI) techniques to examine the spatiotemporal dynamics of I/R injury within the salvaged ischemic penumbra (IP) and reperfused ischemic core (IC) of a rodent model, with the aim of enhancing therapeutic strategies by elucidating these dynamics.

Materials and methods

A total of 17 Sprague–Dawley rats were subjected to 1 h of transient middle cerebral artery occlusion with a suture model. MRI, including diffusion tensor imaging (DTI), T2-weighted imaging, perfusion-weighted imaging, and T1 mapping, was conducted at multiple time points for up to 5 days during the I/R phases. The spatiotemporal dynamics of blood–brain barrier (BBB) modifications were characterized through changes in T1 within the IP and IC regions and compared with mean diffusivity (MD), T2, and cerebral blood flow.

Results

During the I/R phases, the MD of the IC initially decreased, normalized after recanalization, decreased again at 24 h, and peaked on day 5. By contrast, the IP remained relatively stable. Both the IP and IC exhibited hyperperfusion, with the IP reaching its peak at 24 h, followed by resolution, whereas hyperperfusion was maintained in the IC until day 5. Despite hyperperfusion, the IP maintained an intact BBB, whereas the IC experienced persistent BBB leakage. At 24 h, the IC exhibited an increase in the T2 signal, corresponding to regions exhibiting BBB disruption at 5 days.

Conclusions

Hyperperfusion and BBB impairment have distinct patterns in the IP and IC. Quantitative T1 mapping may serve as a supplementary tool for the early detection of malignant hyperemia accompanied by BBB leakage, aiding in precise interventions after recanalization. These findings underscore the value of MRI markers in monitoring ischemia-specific regions and customizing therapeutic strategies to improve patient outcomes.

简介尽管缺血再灌注(I/R)损伤在皮层和皮层下区域之间存在差异,但其对特定区域的影响仍不清楚。在这项研究中,我们使用了多种磁共振成像(MRI)技术来研究啮齿动物模型缺血半影(IP)和再灌注缺血核心(IC)内 I/R 损伤的时空动态,旨在通过阐明这些动态来改进治疗策略:共有 17 只 Sprague-Dawley 大鼠接受了 1 小时的瞬时大脑中动脉闭塞缝合模型。在I/R阶段的长达5天的时间内,在多个时间点进行核磁共振成像,包括弥散张量成像(DTI)、T2加权成像、灌注加权成像和T1图谱。研究人员通过IP和IC区域内T1的变化来描述血脑屏障(BBB)改变的时空动态,并将其与平均弥散度(MD)、T2和脑血流进行比较:结果:在I/R阶段,IC的MD最初下降,再通后恢复正常,24小时后再次下降,并在第5天达到峰值。相比之下,IP 保持相对稳定。IP 和 IC 都表现出高灌注,IP 在 24 小时达到峰值,随后缓解,而 IC 的高灌注一直维持到第 5 天。尽管存在高灌注,IP 仍保持完整的 BBB,而 IC 则出现持续的 BBB 渗漏。24小时后,集成电路的T2信号增加,与5天时出现BBB破坏的区域相对应:结论:高灌注和 BBB 损伤在 IP 和 IC 中具有不同的模式。定量 T1 映像可作为一种辅助工具,用于早期检测伴有 BBB 渗漏的恶性高灌注,有助于在再通后进行精确干预。这些发现强调了磁共振成像标记物在监测缺血特异性区域和定制治疗策略以改善患者预后方面的价值。
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引用次数: 0
Comparison of MRI features among squamous cell carcinoma, adenocarcinoma and adenosquamous carcinoma, usual-type endocervical adenocarcinoma and gastric adenocarcinoma of cervix 宫颈鳞状细胞癌、腺癌和腺鳞癌、普通型宫颈内膜腺癌和胃腺癌的磁共振特征比较。
IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-06 DOI: 10.1016/j.mri.2024.06.002
Mei Ling Xiao , Le Fu , Feng Hua Ma , Yong Ai Li , Guo Fu Zhang , Jin Wei Qiang

Objective

To compare and explore the characteristics of squamous cell carcinoma (SCC), adenocarcinoma (AC) and adenosquamous carcinoma (ASC), usual-type endocervical adenocarcinoma (UEA) and gastric adenocarcinoma (GAC) of cervix.

Materials and methods

A total of 728 cervical cancers (254 cases of AC, 252 cases of ASC, and 222 cases of SCC) confirmed by histopathology were retrospectively reviewed. Among AC, 119 UEA and 47 GAC were included. Clinical baseline data and tumor morphological features on MRI (including tumor location, shape, diameter and volume, margin, growth pattern, presence of fluid component or cyst, heterogenous and peritumoral enhancement) of all cases were collected and analyzed. The signal intensity (SI) of tumor and gluteus maximus muscle were measured and their ratios (SIR) were calculated based on T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), apparent diffusion coefficient (ADC) and contrast-enhanced T1WI at arterial and delay phases (A/DCE-T1WI). These clinical and MRI features were compared between SCC, AC and ASC, UEA and GAC, and the specific ones of each subtype were identified.

Results

There was a significant difference in SCC-Ag, CA-199, CEA, ADC value, SIR-DWI, presence of intratumor cyst and peritumoral enhancement between AC and ASC; in patient age, menopausal status, International Federation of Gynecology and Obstetrics (FIGO) stage, SCC-Ag, CA-125, CA-199, CEA, tumor shape, growth pattern, margin, presence of intratumor fluid component and cyst, tumor diameter and volume, ADC value, SIR-T1WI, SIR-T2WI, and SIR-DWI between SCC and AC, as well as SCC and ASC. Also, there was a significant difference in deep stromal invasion (DSI), peritumoral and heterogenous enhancement between SCC and AC, and in SIR-ACE-T1WI between SCC and ASC. There was a significant difference in reproductive history, menopausal status, FIGO stage, CA-199, DSI, lymph node metastasis (LNM), parametrial invasion (PMI), tumor location, shape, margin, growth pattern, presence of fluid component and cyst, tumor diameter and volume, SIR-T1WI, SIR-DWI, and heterogenous enhancement between GAC and UEA.

Conclusion

The clinical and MRI features with significant differences among SCC, AC and ASC, and between UEA and GAC, can help to identify each subtype of cervical cancer.

目的比较并探讨宫颈鳞状细胞癌(SCC)、腺癌(AC)、腺鳞癌(ASC)、普通型宫颈内膜腺癌(UEA)和胃腺癌(GAC)的特征:回顾性分析经组织病理学证实的 728 例宫颈癌(254 例 AC、252 例 ASC 和 222 例 SCC)。在AC中,包括119例UEA和47例GAC。研究人员收集并分析了所有病例的临床基线数据和核磁共振成像上的肿瘤形态特征(包括肿瘤位置、形状、直径和体积、边缘、生长模式、有无液体成分或囊肿、异质和瘤周强化)。根据 T1 加权成像(T1WI)、T2 加权成像(T2WI)、弥散加权成像(DWI)、表观弥散系数(ADC)以及动脉期和延迟期对比增强 T1WI(A/DCE-T1WI),测量了肿瘤和臀大肌的信号强度(SI),并计算了两者的比值(SIR)。比较了 SCC、AC 和 ASC、UEA 和 GAC 的临床和 MRI 特征,并确定了各亚型的特殊特征:结果:SCC-Ag、CA-199、CEA、ADC 值、SIR-DWI、瘤内囊肿和瘤周强化在 AC 和 ASC 之间存在明显差异;在患者年龄、绝经状态、国际妇产科联盟(FIGO)分期、SCC-Ag、CA-125、CA-199、CEA、肿瘤形状、生长方式、边缘、瘤内液体成分和囊肿的存在、肿瘤直径和体积、ADC值、SIR-T1WI、SIR-T2WI和SIR-DWI方面,SCC与AC以及SCC与ASC存在显著差异。此外,SCC 和 AC 之间在基质深层浸润(DSI)、瘤周和异质增强方面存在显著差异,SCC 和 ASC 之间在 SIR-ACE-T1WI 方面也存在显著差异。GAC和UEA在生育史、绝经状态、FIGO分期、CA-199、DSI、淋巴结转移(LNM)、宫旁侵犯(PMI)、肿瘤位置、形状、边缘、生长方式、有无液体成分和囊肿、肿瘤直径和体积、SIR-T1WI、SIR-DWI和异质强化等方面均有显著差异:结论:SCC、AC 和 ASC 之间以及 UEA 和 GAC 之间差异显著的临床和 MRI 特征有助于鉴别宫颈癌的各个亚型。
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引用次数: 0
Comparison of the value of adipose tissues in abdomen and lumbar vertebra for predicting disease activity in Crohn's disease: A preliminary study based on CSE-MRI 腹部和腰椎脂肪组织在预测克罗恩病疾病活动性方面的价值比较:基于 CSE-MRI 的初步研究
IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-06-04 DOI: 10.1016/j.mri.2024.06.001
Shuling Wang , Guangyu Tang , Shuaishuai Liu, Yun Tu, Rui Ji, Rui Tang, Ting Hua, Jingqi Zhu

Background

To compare the value of adipose tissues in abdomen and lumbar vertebra for predicting Crohn's disease (CD) activity based on chemical shift encoded magnetic resonance imaging (CSE-MRI).

Methods

84 CD patients were divided into remission, mild, and moderate-severely groups based on CD activity index (CDAI). Differences in different adipose parameters [subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), mesenteric fat index (MFI), and bone marrow fat fraction (BMFF)] and blood inflammatory indicators among three groups, as well as the correlation of above parameters and CDAI were analyzed. The areas under the receiver-operating characteristic curves (AUCs) for the parameters selected by multivariate logistic regression analysis for predicting active CD were calculated.

Results

There were no significant differences in VAT and MFI among three groups (both P > 0.05). The cross-sectional areas of SAT in moderate-severe group were significantly lower than those in remission group (P = 0.014). BMFF values of remission group were significantly higher than those in the mild and moderate-severe groups (both P < 0.001). BMFF was negatively correlated with CDAI (r = −0.595, P < 0.001). SAT exhibited no significant correlation with CDAI. Erythrocyte sedimentation rate (ESR) and BMFF were the independent predictors of CDAI. Both combined had a higher diagnostic efficacy for active CD with an AUC of 0.895.

Conclusions

BMFF is the best marker for predicting CD activity in fat parameters of abdomen and lumbar vertebra based on CSE-MRI. The model based on BMFF and ESR has a high efficiency in predicting active CD.

Trial registration

No. 22 K164 (Registered 18-07-2022).

背景比较基于化学位移编码磁共振成像(CSE-MRI)的腹部和腰椎脂肪组织预测克罗恩病(CD)活动性的价值。分析三组患者不同脂肪参数(皮下脂肪组织(SAT)、内脏脂肪组织(VAT)、肠系膜脂肪指数(MFI)和骨髓脂肪分数(BMFF))和血液炎症指标的差异,以及上述参数与 CDAI 的相关性。结果 三组患者的 VAT 和 MFI 无显著差异(P 均为 0.05)。中重度组 SAT 的横截面积明显低于缓解组(P = 0.014)。缓解组的 BMFF 值明显高于轻度组和中度重度组(均为 P < 0.001)。BMFF与CDAI呈负相关(r = -0.595,P <0.001)。SAT 与 CDAI 无明显相关性。红细胞沉降率(ESR)和 BMFF 是 CDAI 的独立预测因子。结论基于 CSE-MRI 的腹部和腰椎脂肪参数中,BMFF 是预测 CD 活动性的最佳标志物。基于BMFF和ESR的模型在预测活动性CD方面具有很高的效率。
{"title":"Comparison of the value of adipose tissues in abdomen and lumbar vertebra for predicting disease activity in Crohn's disease: A preliminary study based on CSE-MRI","authors":"Shuling Wang ,&nbsp;Guangyu Tang ,&nbsp;Shuaishuai Liu,&nbsp;Yun Tu,&nbsp;Rui Ji,&nbsp;Rui Tang,&nbsp;Ting Hua,&nbsp;Jingqi Zhu","doi":"10.1016/j.mri.2024.06.001","DOIUrl":"10.1016/j.mri.2024.06.001","url":null,"abstract":"<div><h3>Background</h3><p>To compare the value of adipose tissues in abdomen and lumbar vertebra for predicting Crohn's disease (CD) activity based on chemical shift encoded magnetic resonance imaging (CSE-MRI).</p></div><div><h3>Methods</h3><p>84 CD patients were divided into remission, mild, and moderate-severely groups based on CD activity index (CDAI). Differences in different adipose parameters [subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), mesenteric fat index (MFI), and bone marrow fat fraction (BMFF)] and blood inflammatory indicators among three groups, as well as the correlation of above parameters and CDAI were analyzed. The areas under the receiver-operating characteristic curves (AUCs) for the parameters selected by multivariate logistic regression analysis for predicting active CD were calculated.</p></div><div><h3>Results</h3><p>There were no significant differences in VAT and MFI among three groups (both <em>P</em> &gt; 0.05). The cross-sectional areas of SAT in moderate-severe group were significantly lower than those in remission group (<em>P</em> = 0.014). BMFF values of remission group were significantly higher than those in the mild and moderate-severe groups (both <em>P</em> &lt; 0.001). BMFF was negatively correlated with CDAI (<em>r</em> = −0.595, <em>P</em> &lt; 0.001). SAT exhibited no significant correlation with CDAI. Erythrocyte sedimentation rate (ESR) and BMFF were the independent predictors of CDAI. Both combined had a higher diagnostic efficacy for active CD with an AUC of 0.895.</p></div><div><h3>Conclusions</h3><p>BMFF is the best marker for predicting CD activity in fat parameters of abdomen and lumbar vertebra based on CSE-MRI. The model based on BMFF and ESR has a high efficiency in predicting active CD.</p></div><div><h3>Trial registration</h3><p>No. 22 K164 (Registered 18-07-2022).</p></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"112 ","pages":"Pages 1-9"},"PeriodicalIF":2.5,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141277219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “The efficacy of using a multiparametric magnetic resonance imaging-based radiomics model to distinguish glioma recurrence from pseudoprogression” [Magnetic Resonance Imaging (2024) 111, 168–178] 使用基于多参数磁共振成像的放射组学模型区分胶质瘤复发和假性进展的有效性》[《磁共振成像》(2024 年)111 期,168-178 页]更正。
IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-05-30 DOI: 10.1016/j.mri.2024.05.014
Fang-Xiong Fu , Qin-Lei Cai , Guo Li , Xiao-Jing Wu , Lan Hong , Wang-Sheng Chen
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引用次数: 0
Predicting isocitrate dehydrogenase status among adult patients with diffuse glioma using patient characteristics, radiomic features, and magnetic resonance imaging: Multi-modal analysis by variable vision transformer 利用患者特征、放射学特征和磁共振成像预测弥漫性胶质瘤成人患者的异柠檬酸脱氢酶状态:通过可变视觉转换器进行多模态分析。
IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-05-29 DOI: 10.1016/j.mri.2024.05.012
Takuma Usuzaki , Ryusei Inamori , Takashi Shizukuishi , Yohei Morishita , Hidenobu Takagi , Mami Ishikuro , Taku Obara , Kei Takase

Objectives

To evaluate the performance of the multimodal model, termed variable Vision Transformer (vViT), in the task of predicting isocitrate dehydrogenase (IDH) status among adult patients with diffuse glioma.

Materials and methods

vViT was designed to predict IDH status using patient characteristics (sex and age), radiomic features, and contrast-enhanced T1-weighted images (CE-T1WI). Radiomic features were extracted from each enhancing tumor (ET), necrotic tumor core (NCR), and peritumoral edematous/infiltrated tissue (ED). CE-T1WI were split into four images and input to vViT. In the training, internal test, and external test, 271 patients with 1070 images (535 IDH wildtype, 535 IDH mutant), 35 patients with 194 images (97 IDH wildtype, 97 IDH mutant), and 291 patients with 872 images (436 IDH wildtype, 436 IDH mutant) were analyzed, respectively. Metrics including accuracy and AUC-ROC were calculated for the internal and external test datasets. Permutation importance analysis combined with the Mann–Whitney U test was performed to compare inputs.

Results

For the internal test dataset, vViT correctly predicted IDH status for all patients. For the external test dataset, an accuracy of 0.935 (95% confidence interval; 0.913–0.945) and AUC-ROC of 0.887 (0.798–0.956) were obtained. For both internal and external test datasets, CE-T1WI ET radiomic features and patient characteristics had higher importance than other inputs (p < 0.05).

Conclusions

The vViT has the potential to be a competent model in predicting IDH status among adult patients with diffuse glioma. Our results indicate that age, sex, and CE-T1WI ET radiomic features have key information in estimating IDH status.

研究目的材料与方法:设计 vViT 的目的是利用患者特征(性别和年龄)、放射学特征和对比增强 T1 加权图像(CE-T1WI)预测 IDH 状态。从每个增强肿瘤(ET)、坏死瘤核(NCR)和瘤周水肿/浸润组织(ED)中提取放射学特征。CE-T1WI 被分成四幅图像并输入 vViT。在训练、内部测试和外部测试中,分别分析了271例患者的1070张图像(535张IDH野生型,535张IDH突变型)、35例患者的194张图像(97张IDH野生型,97张IDH突变型)和291例患者的872张图像(436张IDH野生型,436张IDH突变型)。计算了内部和外部测试数据集的准确度和 AUC-ROC 等指标。在比较输入结果时,进行了置换重要性分析和曼-惠特尼U检验:对于内部测试数据集,vViT 能正确预测所有患者的 IDH 状态。外部测试数据集的准确率为 0.935(95% 置信区间;0.913-0.945),AUC-ROC 为 0.887(0.798-0.956)。在内部和外部测试数据集中,CE-T1WI ET 放射特征和患者特征的重要性均高于其他输入数据(p 结论:vViT 有潜力成为一种新的诊断方法:vViT 有可能成为预测弥漫性胶质瘤成人患者 IDH 状态的有效模型。我们的研究结果表明,年龄、性别和CE-T1WI ET放射学特征是估计IDH状态的关键信息。
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引用次数: 0
Lumbosacral plexus and pudendal nerve magnetic resonance tractography: A systematic review of the clinical applications for pudendal neuralgia 腰骶丛和阴部神经磁共振成像:阴部神经痛临床应用的系统回顾
IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-05-24 DOI: 10.1016/j.mri.2024.05.013
M. Duraffourg , G. Rougereau , R. Fawaz , A. Ltaief , T. Jacquesson , M. Freydier , C. Baude , R. Robert , P. Mertens

Diffusion tensor imaging (DTI) is commonly used to establish three-dimensional mapping of white-matter bundles in the supraspinal central nervous system. DTI has also been the subject of many studies on cranial and peripheral nerves. This non-invasive imaging technique enables virtual dissection of nerves in vivo and provides specific measurements of microstructural integrity. Adverse effects on the lumbosacral plexus may be traumatic, compressive, tumoral, or malformative and thus require dedicated treatment. DTI could lead to new perspectives in pudendal neuralgia diagnosis and management.

We performed a systematic review of all articles or posters reporting results and protocols for lumbosacral plexus mapping using the DTI technique between January 2011 and December 2023.

Twenty-nine articles published were included. Ten studies with a total of 351 participants were able to track the lumbosacral plexus in a physiological context and 19 studies with a total of 402 subjects tracked lumbosacral plexus in a pathological context. Tractography was performed on a 1.5T or 3T MRI system. DTI applied to the lumbosacral plexus and pudendal nerve is feasible but no microstructural normative value has been proposed for the pudendal nerve. The most frequently tracking parameters used in our review are: 3T MRI, b-value of 800 s/mm2, 33 directions, 3 × 3 × 3 mm3, AF threshold of 0.1, minimum fiber length of 10 mm, bending angle of 30°, and 3DT2 TSE anatomical resolution.

Increased use of DTI could lead to new perspectives in the management of pudendal neuralgia due to entrapment syndrome, whether at the diagnostic, prognostic, or preoperative planning level.

Prospective studies of healthy subjects and patients with the optimal acquisition parameters described above are needed to establish the accuracy of MR tractography for diagnosing pudendal neuralgia and other intrapelvic nerve entrapments.

弥散张量成像(DTI)通常用于绘制脊髓上中枢神经系统白质束的三维图。DTI 也是许多颅神经和周围神经研究的主题。这种非侵入性成像技术可在体内对神经进行虚拟解剖,并对微观结构的完整性进行具体测量。腰骶神经丛受到的不良影响可能是创伤性、压迫性、肿瘤性或畸形性的,因此需要专门的治疗。我们对 2011 年 1 月至 2023 年 12 月间所有报道使用 DTI 技术绘制腰骶神经丛图的结果和方案的文章或海报进行了系统性回顾。其中,10 项研究共 351 名受试者追踪了生理情况下的腰骶神经丛,19 项研究共 402 名受试者追踪了病理情况下的腰骶神经丛。在 1.5T 或 3T 核磁共振成像系统上进行了痕量造影。将 DTI 应用于腰骶神经丛和阴部神经是可行的,但尚未提出阴部神经的微观结构规范值。在我们的综述中,最常用的跟踪参数是增加 DTI 的使用可为夹层综合征引起的阴股神经痛的治疗带来新的视角,无论是在诊断、预后还是术前规划层面。需要对健康受试者和采用上述最佳采集参数的患者进行前瞻性研究,以确定磁共振束流成像诊断阴部神经痛和其他骨盆内神经卡压的准确性。
{"title":"Lumbosacral plexus and pudendal nerve magnetic resonance tractography: A systematic review of the clinical applications for pudendal neuralgia","authors":"M. Duraffourg ,&nbsp;G. Rougereau ,&nbsp;R. Fawaz ,&nbsp;A. Ltaief ,&nbsp;T. Jacquesson ,&nbsp;M. Freydier ,&nbsp;C. Baude ,&nbsp;R. Robert ,&nbsp;P. Mertens","doi":"10.1016/j.mri.2024.05.013","DOIUrl":"10.1016/j.mri.2024.05.013","url":null,"abstract":"<div><p>Diffusion tensor imaging (DTI) is commonly used to establish three-dimensional mapping of white-matter bundles in the supraspinal central nervous system. DTI has also been the subject of many studies on cranial and peripheral nerves. This non-invasive imaging technique enables virtual dissection of nerves in vivo and provides specific measurements of microstructural integrity. Adverse effects on the lumbosacral plexus may be traumatic, compressive, tumoral, or malformative and thus require dedicated treatment. DTI could lead to new perspectives in pudendal neuralgia diagnosis and management.</p><p>We performed a systematic review of all articles or posters reporting results and protocols for lumbosacral plexus mapping using the DTI technique between January 2011 and December 2023.</p><p>Twenty-nine articles published were included. Ten studies with a total of 351 participants were able to track the lumbosacral plexus in a physiological context and 19 studies with a total of 402 subjects tracked lumbosacral plexus in a pathological context. Tractography was performed on a 1.5T or 3T MRI system. DTI applied to the lumbosacral plexus and pudendal nerve is feasible but no microstructural normative value has been proposed for the pudendal nerve. The most frequently tracking parameters used in our review are: 3T MRI, b-value of 800 s/mm<sup>2</sup>, 33 directions, 3 × 3 × 3 mm<sup>3</sup>, AF threshold of 0.1, minimum fiber length of 10 mm, bending angle of 30°, and 3DT2 TSE anatomical resolution.</p><p>Increased use of DTI could lead to new perspectives in the management of pudendal neuralgia due to entrapment syndrome, whether at the diagnostic, prognostic, or preoperative planning level.</p><p>Prospective studies of healthy subjects and patients with the optimal acquisition parameters described above are needed to establish the accuracy of MR tractography for diagnosing pudendal neuralgia and other intrapelvic nerve entrapments.</p></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"112 ","pages":"Pages 18-26"},"PeriodicalIF":2.5,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141144065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histogram analysis of intravoxel incoherent motion imaging: Correlation with molecular prognostic factors and combined subtypes of breast cancer 体外非相干运动成像的直方图分析:与乳腺癌分子预后因素和综合亚型的相关性。
IF 2.5 4区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Pub Date : 2024-05-20 DOI: 10.1016/j.mri.2024.05.010
Dan Yang, Yike Ren, Chunhong Wang

Purpose

To look for links between diffusion and IVIM parameters and different molecular subtypes and prognostic factors through histogram analysis.

Materials and methods

A total of 139 patients with breast cancer who had pre-operative MRI examinations were enrolled in this retrospective study. Histograms of the diffusion and IVIM parameters were analyzed for the whole tumor, and an association was investigated between the parameters and the different molecular prognostic factors and subtypes using the nonparametric test, Spearman's rank correlation, and receiver operating characteristic (ROC) curve.

Results

The histogram metrics of the diffusion and IVIM parameters were significantly different for molecular prognostic factors such as human epidermal receptor factor-2 (HER2), progesterone receptor, estrogen receptor, and ki-67. All histogram metrics displayed a poor correlation with all groups (r = −0.28-0.29). There were significant differences in the histogram metrics for the Luminal B-HER2 (−) vs. HER2-positive (non-luminal) subtypes in the mean and 10th percentile D, with the area under the curves (AUCs) of 0.742 and 0.700, respectively, and for the Luminal A and HER2-positive (non-luminal) subtypes in the 90th percentile and entropy of D*, with AUCs of 0.769 and 0.727, respectively.

Conclusion

The histogram metrics of IVIM parameters exhibited links with breast cancer prognosis factors and combined subtypes.

目的:通过直方图分析寻找弥散和IVIM参数与不同分子亚型和预后因素之间的联系:这项回顾性研究共纳入了 139 名接受术前磁共振成像检查的乳腺癌患者。采用非参数检验、Spearman秩相关和接收器操作特征曲线(ROC)分析了整个肿瘤的弥散和IVIM参数直方图,并研究了这些参数与不同分子预后因素和亚型之间的关联:扩散和IVIM参数的直方图度量在人表皮受体因子-2(HER2)、孕酮受体、雌激素受体和ki-67等分子预后因素上有显著差异。所有直方图指标与所有组的相关性都很差(r = -0.28-0.29)。Luminal B-HER2(-)亚型与 HER2 阳性(非腔道)亚型的直方图指标在平均值和第 10 百分位数 D 方面存在明显差异,曲线下面积(AUC)分别为 0.742 和 0.700;Luminal A 和 HER2 阳性(非腔道)亚型在第 90 百分位数和 D* 的熵方面存在明显差异,AUC 分别为 0.769 和 0.727:IVIM参数的直方图度量显示了与乳腺癌预后因素和综合亚型的联系。
{"title":"Histogram analysis of intravoxel incoherent motion imaging: Correlation with molecular prognostic factors and combined subtypes of breast cancer","authors":"Dan Yang,&nbsp;Yike Ren,&nbsp;Chunhong Wang","doi":"10.1016/j.mri.2024.05.010","DOIUrl":"10.1016/j.mri.2024.05.010","url":null,"abstract":"<div><h3>Purpose</h3><p>To look for links between diffusion and IVIM parameters and different molecular subtypes and prognostic factors through histogram analysis.</p></div><div><h3>Materials and methods</h3><p>A total of 139 patients with breast cancer who had pre-operative MRI examinations were enrolled in this retrospective study. Histograms of the diffusion and IVIM parameters were analyzed for the whole tumor, and an association was investigated between the parameters and the different molecular prognostic factors and subtypes using the nonparametric test, Spearman's rank correlation, and receiver operating characteristic (ROC) curve.</p></div><div><h3>Results</h3><p>The histogram metrics of the diffusion and IVIM parameters were significantly different for molecular prognostic factors such as human epidermal receptor factor-2 (HER2), progesterone receptor, estrogen receptor, and ki-67. All histogram metrics displayed a poor correlation with all groups (<em>r</em> = −0.28-0.29). There were significant differences in the histogram metrics for the Luminal B-HER2 (−) vs. HER2-positive (non-luminal) subtypes in the mean and 10th percentile D, with the area under the curves (AUCs) of 0.742 and 0.700, respectively, and for the Luminal A and HER2-positive (non-luminal) subtypes in the 90th percentile and entropy of D*, with AUCs of 0.769 and 0.727, respectively.</p></div><div><h3>Conclusion</h3><p>The histogram metrics of IVIM parameters exhibited links with breast cancer prognosis factors and combined subtypes.</p></div>","PeriodicalId":18165,"journal":{"name":"Magnetic resonance imaging","volume":"111 ","pages":"Pages 210-216"},"PeriodicalIF":2.5,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141082011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Magnetic resonance imaging
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